Amino acid dipepetide frequency for His 2 virus (His2V) (Haloarcula hispanica virus 2)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.055AlaAla: 3.055 ± 0.906
0.436AlaCys: 0.436 ± 0.276
2.4AlaAsp: 2.4 ± 0.807
5.455AlaGlu: 5.455 ± 1.174
2.837AlaPhe: 2.837 ± 0.966
3.273AlaGly: 3.273 ± 0.906
1.309AlaHis: 1.309 ± 0.443
5.673AlaIle: 5.673 ± 1.204
3.709AlaLys: 3.709 ± 0.873
4.8AlaLeu: 4.8 ± 1.059
1.964AlaMet: 1.964 ± 0.721
5.019AlaAsn: 5.019 ± 1.193
1.746AlaPro: 1.746 ± 0.795
2.4AlaGln: 2.4 ± 1.04
1.964AlaArg: 1.964 ± 0.745
4.8AlaSer: 4.8 ± 1.068
5.891AlaThr: 5.891 ± 1.125
3.273AlaVal: 3.273 ± 1.055
0.655AlaTrp: 0.655 ± 0.39
4.582AlaTyr: 4.582 ± 0.746
0.0AlaXaa: 0.0 ± 0.0
Cys
0.436CysAla: 0.436 ± 0.335
0.436CysCys: 0.436 ± 0.365
1.746CysAsp: 1.746 ± 0.72
1.309CysGlu: 1.309 ± 0.971
0.0CysPhe: 0.0 ± 0.0
2.4CysGly: 2.4 ± 0.976
0.218CysHis: 0.218 ± 0.266
0.436CysIle: 0.436 ± 0.335
1.746CysLys: 1.746 ± 0.647
0.655CysLeu: 0.655 ± 0.321
1.091CysMet: 1.091 ± 0.485
0.873CysAsn: 0.873 ± 0.506
1.309CysPro: 1.309 ± 0.615
0.436CysGln: 0.436 ± 0.251
0.873CysArg: 0.873 ± 0.508
0.218CysSer: 0.218 ± 0.217
0.655CysThr: 0.655 ± 0.364
1.091CysVal: 1.091 ± 0.468
0.0CysTrp: 0.0 ± 0.0
0.436CysTyr: 0.436 ± 0.329
0.0CysXaa: 0.0 ± 0.0
Asp
5.237AspAla: 5.237 ± 1.447
1.964AspCys: 1.964 ± 0.519
3.491AspAsp: 3.491 ± 0.669
4.582AspGlu: 4.582 ± 1.061
2.182AspPhe: 2.182 ± 0.705
3.055AspGly: 3.055 ± 0.596
0.218AspHis: 0.218 ± 0.255
5.237AspIle: 5.237 ± 1.207
5.237AspLys: 5.237 ± 1.257
4.364AspLeu: 4.364 ± 0.915
2.4AspMet: 2.4 ± 0.612
3.055AspAsn: 3.055 ± 0.77
0.655AspPro: 0.655 ± 0.309
1.527AspGln: 1.527 ± 0.597
1.964AspArg: 1.964 ± 0.569
3.491AspSer: 3.491 ± 0.885
3.928AspThr: 3.928 ± 0.774
3.928AspVal: 3.928 ± 1.139
0.218AspTrp: 0.218 ± 0.197
3.491AspTyr: 3.491 ± 1.142
0.0AspXaa: 0.0 ± 0.0
Glu
4.364GluAla: 4.364 ± 1.381
1.091GluCys: 1.091 ± 0.513
1.964GluAsp: 1.964 ± 0.782
6.11GluGlu: 6.11 ± 1.902
3.273GluPhe: 3.273 ± 0.687
4.146GluGly: 4.146 ± 0.861
1.746GluHis: 1.746 ± 0.842
4.582GluIle: 4.582 ± 0.996
4.8GluLys: 4.8 ± 1.047
7.201GluLeu: 7.201 ± 1.248
3.055GluMet: 3.055 ± 0.977
5.019GluAsn: 5.019 ± 1.166
2.182GluPro: 2.182 ± 0.65
7.201GluGln: 7.201 ± 1.301
3.273GluArg: 3.273 ± 0.719
6.982GluSer: 6.982 ± 1.152
5.455GluThr: 5.455 ± 1.001
5.237GluVal: 5.237 ± 1.078
0.655GluTrp: 0.655 ± 0.394
5.673GluTyr: 5.673 ± 0.924
0.0GluXaa: 0.0 ± 0.0
Phe
3.055PheAla: 3.055 ± 0.826
0.0PheCys: 0.0 ± 0.0
3.273PheAsp: 3.273 ± 1.161
4.146PheGlu: 4.146 ± 1.064
0.655PhePhe: 0.655 ± 0.364
1.964PheGly: 1.964 ± 0.55
0.655PheHis: 0.655 ± 0.366
2.182PheIle: 2.182 ± 0.725
0.873PheLys: 0.873 ± 0.441
0.655PheLeu: 0.655 ± 0.521
1.309PheMet: 1.309 ± 0.459
1.309PheAsn: 1.309 ± 0.469
0.873PhePro: 0.873 ± 0.388
0.873PheGln: 0.873 ± 0.438
0.873PheArg: 0.873 ± 0.367
1.091PheSer: 1.091 ± 0.511
2.837PheThr: 2.837 ± 1.016
4.146PheVal: 4.146 ± 1.027
0.655PheTrp: 0.655 ± 0.335
1.527PheTyr: 1.527 ± 0.663
0.0PheXaa: 0.0 ± 0.0
Gly
2.837GlyAla: 2.837 ± 0.787
0.436GlyCys: 0.436 ± 0.296
4.146GlyAsp: 4.146 ± 0.847
4.146GlyGlu: 4.146 ± 0.926
3.055GlyPhe: 3.055 ± 0.807
1.964GlyGly: 1.964 ± 0.747
1.309GlyHis: 1.309 ± 0.677
6.328GlyIle: 6.328 ± 0.828
4.582GlyLys: 4.582 ± 1.414
3.273GlyLeu: 3.273 ± 0.597
2.4GlyMet: 2.4 ± 0.862
5.673GlyAsn: 5.673 ± 1.052
0.436GlyPro: 0.436 ± 0.315
1.746GlyGln: 1.746 ± 0.717
1.964GlyArg: 1.964 ± 0.69
3.709GlySer: 3.709 ± 1.148
6.982GlyThr: 6.982 ± 1.971
4.8GlyVal: 4.8 ± 1.071
0.436GlyTrp: 0.436 ± 0.36
2.618GlyTyr: 2.618 ± 0.578
0.0GlyXaa: 0.0 ± 0.0
His
1.091HisAla: 1.091 ± 0.683
0.655HisCys: 0.655 ± 0.472
1.527HisAsp: 1.527 ± 0.518
0.436HisGlu: 0.436 ± 0.271
0.436HisPhe: 0.436 ± 0.289
1.309HisGly: 1.309 ± 0.507
0.0HisHis: 0.0 ± 0.0
0.655HisIle: 0.655 ± 0.369
1.091HisLys: 1.091 ± 0.541
0.436HisLeu: 0.436 ± 0.387
1.091HisMet: 1.091 ± 0.463
0.873HisAsn: 0.873 ± 0.447
0.873HisPro: 0.873 ± 0.452
0.655HisGln: 0.655 ± 0.454
0.655HisArg: 0.655 ± 0.468
0.873HisSer: 0.873 ± 0.342
1.091HisThr: 1.091 ± 0.538
1.746HisVal: 1.746 ± 0.518
0.218HisTrp: 0.218 ± 0.249
1.746HisTyr: 1.746 ± 0.554
0.0HisXaa: 0.0 ± 0.0
Ile
4.364IleAla: 4.364 ± 0.945
0.436IleCys: 0.436 ± 0.353
5.673IleAsp: 5.673 ± 0.998
8.292IleGlu: 8.292 ± 0.968
1.309IlePhe: 1.309 ± 0.498
6.328IleGly: 6.328 ± 0.811
1.091IleHis: 1.091 ± 0.38
2.618IleIle: 2.618 ± 0.65
2.618IleLys: 2.618 ± 0.597
3.491IleLeu: 3.491 ± 0.657
2.837IleMet: 2.837 ± 0.74
3.491IleAsn: 3.491 ± 0.946
4.146IlePro: 4.146 ± 0.957
2.837IleGln: 2.837 ± 0.815
2.182IleArg: 2.182 ± 0.827
5.891IleSer: 5.891 ± 1.175
4.582IleThr: 4.582 ± 0.841
5.455IleVal: 5.455 ± 1.053
0.436IleTrp: 0.436 ± 0.278
0.873IleTyr: 0.873 ± 0.397
0.0IleXaa: 0.0 ± 0.0
Lys
3.709LysAla: 3.709 ± 0.876
2.4LysCys: 2.4 ± 0.89
3.928LysAsp: 3.928 ± 0.839
4.8LysGlu: 4.8 ± 1.402
2.4LysPhe: 2.4 ± 0.921
3.055LysGly: 3.055 ± 0.984
1.746LysHis: 1.746 ± 0.687
3.491LysIle: 3.491 ± 0.632
5.455LysLys: 5.455 ± 1.052
2.4LysLeu: 2.4 ± 0.735
1.746LysMet: 1.746 ± 0.716
3.055LysAsn: 3.055 ± 0.678
2.618LysPro: 2.618 ± 1.276
2.182LysGln: 2.182 ± 0.533
3.491LysArg: 3.491 ± 0.92
3.491LysSer: 3.491 ± 0.872
5.891LysThr: 5.891 ± 1.08
3.491LysVal: 3.491 ± 0.918
0.218LysTrp: 0.218 ± 0.24
1.527LysTyr: 1.527 ± 0.384
0.0LysXaa: 0.0 ± 0.0
Leu
4.146LeuAla: 4.146 ± 0.751
0.873LeuCys: 0.873 ± 0.633
3.491LeuAsp: 3.491 ± 1.053
5.891LeuGlu: 5.891 ± 1.508
1.527LeuPhe: 1.527 ± 0.421
4.8LeuGly: 4.8 ± 1.277
1.309LeuHis: 1.309 ± 0.506
4.8LeuIle: 4.8 ± 0.835
5.019LeuLys: 5.019 ± 0.722
5.673LeuLeu: 5.673 ± 1.284
3.273LeuMet: 3.273 ± 0.928
2.618LeuAsn: 2.618 ± 0.804
1.746LeuPro: 1.746 ± 0.655
1.527LeuGln: 1.527 ± 0.48
4.146LeuArg: 4.146 ± 0.844
3.491LeuSer: 3.491 ± 0.874
3.709LeuThr: 3.709 ± 1.236
6.546LeuVal: 6.546 ± 1.426
0.218LeuTrp: 0.218 ± 0.202
2.182LeuTyr: 2.182 ± 0.61
0.0LeuXaa: 0.0 ± 0.0
Met
3.928MetAla: 3.928 ± 1.138
0.655MetCys: 0.655 ± 0.387
1.527MetAsp: 1.527 ± 0.469
1.309MetGlu: 1.309 ± 0.473
1.091MetPhe: 1.091 ± 0.46
1.964MetGly: 1.964 ± 0.656
0.436MetHis: 0.436 ± 0.382
1.746MetIle: 1.746 ± 0.617
2.837MetLys: 2.837 ± 0.893
2.618MetLeu: 2.618 ± 0.639
0.436MetMet: 0.436 ± 0.284
2.837MetAsn: 2.837 ± 0.721
0.655MetPro: 0.655 ± 0.374
2.618MetGln: 2.618 ± 0.798
0.655MetArg: 0.655 ± 0.474
1.746MetSer: 1.746 ± 0.639
1.964MetThr: 1.964 ± 0.763
1.527MetVal: 1.527 ± 0.634
0.655MetTrp: 0.655 ± 0.351
0.873MetTyr: 0.873 ± 0.446
0.0MetXaa: 0.0 ± 0.0
Asn
4.582AsnAla: 4.582 ± 1.035
0.873AsnCys: 0.873 ± 0.479
3.709AsnAsp: 3.709 ± 0.898
5.019AsnGlu: 5.019 ± 1.273
0.873AsnPhe: 0.873 ± 0.47
4.364AsnGly: 4.364 ± 0.813
0.873AsnHis: 0.873 ± 0.35
4.364AsnIle: 4.364 ± 0.736
3.709AsnLys: 3.709 ± 0.816
5.019AsnLeu: 5.019 ± 0.906
1.309AsnMet: 1.309 ± 0.447
4.146AsnAsn: 4.146 ± 1.362
2.618AsnPro: 2.618 ± 0.898
0.655AsnGln: 0.655 ± 0.393
1.964AsnArg: 1.964 ± 0.522
2.618AsnSer: 2.618 ± 0.758
5.019AsnThr: 5.019 ± 1.429
4.8AsnVal: 4.8 ± 1.804
1.091AsnTrp: 1.091 ± 0.432
2.837AsnTyr: 2.837 ± 0.98
0.0AsnXaa: 0.0 ± 0.0
Pro
2.4ProAla: 2.4 ± 0.799
0.655ProCys: 0.655 ± 0.43
2.182ProAsp: 2.182 ± 0.661
2.837ProGlu: 2.837 ± 0.792
1.746ProPhe: 1.746 ± 0.722
0.655ProGly: 0.655 ± 0.54
1.091ProHis: 1.091 ± 0.459
2.618ProIle: 2.618 ± 0.629
1.309ProLys: 1.309 ± 0.396
2.182ProLeu: 2.182 ± 0.547
0.218ProMet: 0.218 ± 0.173
2.4ProAsn: 2.4 ± 0.628
0.655ProPro: 0.655 ± 0.34
0.873ProGln: 0.873 ± 0.48
0.655ProArg: 0.655 ± 0.319
1.527ProSer: 1.527 ± 0.605
1.964ProThr: 1.964 ± 0.742
1.309ProVal: 1.309 ± 0.541
0.0ProTrp: 0.0 ± 0.0
0.436ProTyr: 0.436 ± 0.252
0.0ProXaa: 0.0 ± 0.0
Gln
2.618GlnAla: 2.618 ± 0.611
0.655GlnCys: 0.655 ± 0.45
2.4GlnAsp: 2.4 ± 0.588
2.4GlnGlu: 2.4 ± 0.734
0.873GlnPhe: 0.873 ± 0.376
1.309GlnGly: 1.309 ± 0.516
1.091GlnHis: 1.091 ± 0.635
3.273GlnIle: 3.273 ± 0.767
2.182GlnLys: 2.182 ± 0.744
3.055GlnLeu: 3.055 ± 0.783
0.873GlnMet: 0.873 ± 0.397
2.618GlnAsn: 2.618 ± 1.083
0.873GlnPro: 0.873 ± 0.401
1.964GlnGln: 1.964 ± 0.844
1.746GlnArg: 1.746 ± 0.457
2.837GlnSer: 2.837 ± 1.099
2.837GlnThr: 2.837 ± 0.823
2.182GlnVal: 2.182 ± 0.703
0.436GlnTrp: 0.436 ± 0.264
2.837GlnTyr: 2.837 ± 0.6
0.0GlnXaa: 0.0 ± 0.0
Arg
1.091ArgAla: 1.091 ± 0.419
1.309ArgCys: 1.309 ± 0.617
1.964ArgAsp: 1.964 ± 0.454
3.709ArgGlu: 3.709 ± 0.71
1.964ArgPhe: 1.964 ± 0.545
1.309ArgGly: 1.309 ± 0.606
0.218ArgHis: 0.218 ± 0.173
2.182ArgIle: 2.182 ± 0.676
3.491ArgLys: 3.491 ± 0.88
1.746ArgLeu: 1.746 ± 0.613
0.873ArgMet: 0.873 ± 0.443
3.273ArgAsn: 3.273 ± 0.961
1.309ArgPro: 1.309 ± 0.693
1.091ArgGln: 1.091 ± 0.531
1.527ArgArg: 1.527 ± 0.623
2.837ArgSer: 2.837 ± 0.701
3.273ArgThr: 3.273 ± 0.808
2.618ArgVal: 2.618 ± 0.635
0.218ArgTrp: 0.218 ± 0.207
1.309ArgTyr: 1.309 ± 0.544
0.0ArgXaa: 0.0 ± 0.0
Ser
5.019SerAla: 5.019 ± 0.839
1.091SerCys: 1.091 ± 0.556
4.8SerAsp: 4.8 ± 1.202
6.11SerGlu: 6.11 ± 0.943
1.309SerPhe: 1.309 ± 0.351
7.201SerGly: 7.201 ± 1.186
1.309SerHis: 1.309 ± 0.439
4.582SerIle: 4.582 ± 1.248
3.709SerLys: 3.709 ± 0.812
6.11SerLeu: 6.11 ± 0.935
1.091SerMet: 1.091 ± 0.488
2.618SerAsn: 2.618 ± 0.642
1.309SerPro: 1.309 ± 0.532
2.618SerGln: 2.618 ± 0.863
0.873SerArg: 0.873 ± 0.37
5.455SerSer: 5.455 ± 1.235
3.055SerThr: 3.055 ± 0.568
3.273SerVal: 3.273 ± 0.907
0.655SerTrp: 0.655 ± 0.402
2.837SerTyr: 2.837 ± 0.674
0.0SerXaa: 0.0 ± 0.0
Thr
4.582ThrAla: 4.582 ± 1.21
1.527ThrCys: 1.527 ± 0.605
4.582ThrAsp: 4.582 ± 0.949
5.455ThrGlu: 5.455 ± 0.952
3.273ThrPhe: 3.273 ± 0.918
3.709ThrGly: 3.709 ± 1.072
0.655ThrHis: 0.655 ± 0.416
7.201ThrIle: 7.201 ± 1.94
2.837ThrLys: 2.837 ± 1.0
3.928ThrLeu: 3.928 ± 0.648
2.4ThrMet: 2.4 ± 0.795
5.237ThrAsn: 5.237 ± 1.254
1.091ThrPro: 1.091 ± 0.435
3.491ThrGln: 3.491 ± 0.774
3.491ThrArg: 3.491 ± 0.732
5.891ThrSer: 5.891 ± 1.388
4.364ThrThr: 4.364 ± 1.23
5.455ThrVal: 5.455 ± 1.472
0.873ThrTrp: 0.873 ± 0.503
5.019ThrTyr: 5.019 ± 1.43
0.0ThrXaa: 0.0 ± 0.0
Val
5.019ValAla: 5.019 ± 0.894
0.655ValCys: 0.655 ± 0.367
2.837ValAsp: 2.837 ± 0.629
5.019ValGlu: 5.019 ± 0.752
2.837ValPhe: 2.837 ± 0.818
6.546ValGly: 6.546 ± 1.93
1.091ValHis: 1.091 ± 0.618
3.709ValIle: 3.709 ± 1.191
4.146ValLys: 4.146 ± 0.815
5.673ValLeu: 5.673 ± 1.901
2.4ValMet: 2.4 ± 0.652
2.4ValAsn: 2.4 ± 0.569
1.527ValPro: 1.527 ± 0.514
2.837ValGln: 2.837 ± 1.11
3.273ValArg: 3.273 ± 0.868
3.928ValSer: 3.928 ± 0.815
8.292ValThr: 8.292 ± 1.877
6.982ValVal: 6.982 ± 1.524
1.527ValTrp: 1.527 ± 0.653
2.182ValTyr: 2.182 ± 0.705
0.0ValXaa: 0.0 ± 0.0
Trp
0.436TrpAla: 0.436 ± 0.338
0.0TrpCys: 0.0 ± 0.0
0.873TrpAsp: 0.873 ± 0.356
0.873TrpGlu: 0.873 ± 0.339
0.436TrpPhe: 0.436 ± 0.293
0.436TrpGly: 0.436 ± 0.29
0.0TrpHis: 0.0 ± 0.0
0.436TrpIle: 0.436 ± 0.278
0.218TrpLys: 0.218 ± 0.258
1.309TrpLeu: 1.309 ± 0.423
0.218TrpMet: 0.218 ± 0.26
0.873TrpAsn: 0.873 ± 0.405
0.218TrpPro: 0.218 ± 0.217
0.436TrpGln: 0.436 ± 0.337
0.218TrpArg: 0.218 ± 0.207
0.436TrpSer: 0.436 ± 0.289
0.436TrpThr: 0.436 ± 0.293
1.091TrpVal: 1.091 ± 0.493
0.0TrpTrp: 0.0 ± 0.0
0.218TrpTyr: 0.218 ± 0.173
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.273TyrAla: 3.273 ± 0.746
0.218TyrCys: 0.218 ± 0.263
3.709TyrAsp: 3.709 ± 1.23
6.328TyrGlu: 6.328 ± 1.052
0.873TyrPhe: 0.873 ± 0.44
3.055TyrGly: 3.055 ± 0.86
1.091TyrHis: 1.091 ± 0.396
2.837TyrIle: 2.837 ± 0.632
1.527TyrLys: 1.527 ± 0.564
2.4TyrLeu: 2.4 ± 0.759
0.873TyrMet: 0.873 ± 0.486
3.055TyrAsn: 3.055 ± 0.837
0.873TyrPro: 0.873 ± 0.519
1.091TyrGln: 1.091 ± 0.576
1.527TyrArg: 1.527 ± 0.775
3.709TyrSer: 3.709 ± 0.801
2.837TyrThr: 2.837 ± 0.704
3.928TyrVal: 3.928 ± 0.937
0.0TyrTrp: 0.0 ± 0.0
1.964TyrTyr: 1.964 ± 0.544
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 35 proteins (4584 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski