Amino acid dipepetide frequency for Puniceibacterium antarcticum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	15.751AlaAla: 15.751 ± 0.14	1.118AlaCys: 1.118 ± 0.027	6.843AlaAsp: 6.843 ± 0.074	7.423AlaGlu: 7.423 ± 0.065	4.294AlaPhe: 4.294 ± 0.056	9.782AlaGly: 9.782 ± 0.09	2.268AlaHis: 2.268 ± 0.039	5.788AlaIle: 5.788 ± 0.06	3.796AlaLys: 3.796 ± 0.058	14.037AlaLeu: 14.037 ± 0.119	3.835AlaMet: 3.835 ± 0.051	2.688AlaAsn: 2.688 ± 0.042	5.56AlaPro: 5.56 ± 0.07	4.863AlaGln: 4.863 ± 0.057	8.475AlaArg: 8.475 ± 0.083	5.762AlaSer: 5.762 ± 0.064	6.129AlaThr: 6.129 ± 0.057	8.34AlaVal: 8.34 ± 0.087	1.41AlaTrp: 1.41 ± 0.03	2.494AlaTyr: 2.494 ± 0.04	0.0AlaXaa: 0.0 ± 0.0
Cys	1.14CysAla: 1.14 ± 0.028	0.129CysCys: 0.129 ± 0.011	0.607CysAsp: 0.607 ± 0.02	0.417CysGlu: 0.417 ± 0.016	0.321CysPhe: 0.321 ± 0.015	0.96CysGly: 0.96 ± 0.028	0.283CysHis: 0.283 ± 0.014	0.451CysIle: 0.451 ± 0.02	0.225CysLys: 0.225 ± 0.014	0.894CysLeu: 0.894 ± 0.022	0.184CysMet: 0.184 ± 0.011	0.236CysAsn: 0.236 ± 0.012	0.527CysPro: 0.527 ± 0.018	0.265CysGln: 0.265 ± 0.012	0.583CysArg: 0.583 ± 0.018	0.486CysSer: 0.486 ± 0.018	0.473CysThr: 0.473 ± 0.017	0.664CysVal: 0.664 ± 0.021	0.142CysTrp: 0.142 ± 0.008	0.199CysTyr: 0.199 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	7.18AspAla: 7.18 ± 0.08	0.529AspCys: 0.529 ± 0.02	3.096AspAsp: 3.096 ± 0.044	3.124AspGlu: 3.124 ± 0.043	2.322AspPhe: 2.322 ± 0.042	5.469AspGly: 5.469 ± 0.072	1.405AspHis: 1.405 ± 0.032	3.189AspIle: 3.189 ± 0.047	1.75AspLys: 1.75 ± 0.039	6.718AspLeu: 6.718 ± 0.064	1.749AspMet: 1.749 ± 0.033	1.243AspAsn: 1.243 ± 0.028	3.532AspPro: 3.532 ± 0.052	2.041AspGln: 2.041 ± 0.034	4.077AspArg: 4.077 ± 0.05	2.534AspSer: 2.534 ± 0.043	3.237AspThr: 3.237 ± 0.052	4.287AspVal: 4.287 ± 0.06	1.179AspTrp: 1.179 ± 0.029	1.465AspTyr: 1.465 ± 0.028	0.0AspXaa: 0.0 ± 0.0
Glu	7.186GluAla: 7.186 ± 0.078	0.329GluCys: 0.329 ± 0.015	3.117GluAsp: 3.117 ± 0.043	3.085GluGlu: 3.085 ± 0.059	1.666GluPhe: 1.666 ± 0.04	4.282GluGly: 4.282 ± 0.048	1.121GluHis: 1.121 ± 0.025	3.356GluIle: 3.356 ± 0.048	2.065GluLys: 2.065 ± 0.042	4.876GluLeu: 4.876 ± 0.059	1.78GluMet: 1.78 ± 0.034	1.64GluAsn: 1.64 ± 0.035	2.252GluPro: 2.252 ± 0.04	1.957GluGln: 1.957 ± 0.035	4.0GluArg: 4.0 ± 0.055	2.33GluSer: 2.33 ± 0.037	3.647GluThr: 3.647 ± 0.052	4.142GluVal: 4.142 ± 0.055	0.623GluTrp: 0.623 ± 0.021	1.02GluTyr: 1.02 ± 0.024	0.0GluXaa: 0.0 ± 0.0
Phe	4.522PheAla: 4.522 ± 0.066	0.417PheCys: 0.417 ± 0.015	2.862PheAsp: 2.862 ± 0.048	2.135PheGlu: 2.135 ± 0.035	1.455PhePhe: 1.455 ± 0.038	3.811PheGly: 3.811 ± 0.053	0.776PheHis: 0.776 ± 0.023	1.625PheIle: 1.625 ± 0.034	0.94PheLys: 0.94 ± 0.027	3.467PheLeu: 3.467 ± 0.047	0.9PheMet: 0.9 ± 0.018	1.052PheAsn: 1.052 ± 0.028	1.518PhePro: 1.518 ± 0.031	1.113PheGln: 1.113 ± 0.027	2.106PheArg: 2.106 ± 0.037	2.207PheSer: 2.207 ± 0.043	2.065PheThr: 2.065 ± 0.035	2.716PheVal: 2.716 ± 0.042	0.595PheTrp: 0.595 ± 0.022	0.897PheTyr: 0.897 ± 0.029	0.0PheXaa: 0.0 ± 0.0
Gly	9.697GlyAla: 9.697 ± 0.083	0.874GlyCys: 0.874 ± 0.025	4.556GlyAsp: 4.556 ± 0.054	4.194GlyGlu: 4.194 ± 0.049	3.668GlyPhe: 3.668 ± 0.05	7.145GlyGly: 7.145 ± 0.091	1.917GlyHis: 1.917 ± 0.037	4.521GlyIle: 4.521 ± 0.056	3.08GlyLys: 3.08 ± 0.046	9.197GlyLeu: 9.197 ± 0.102	2.656GlyMet: 2.656 ± 0.049	2.15GlyAsn: 2.15 ± 0.044	3.509GlyPro: 3.509 ± 0.047	3.317GlyGln: 3.317 ± 0.05	5.522GlyArg: 5.522 ± 0.066	4.42GlySer: 4.42 ± 0.062	4.979GlyThr: 4.979 ± 0.054	6.39GlyVal: 6.39 ± 0.062	1.475GlyTrp: 1.475 ± 0.03	2.305GlyTyr: 2.305 ± 0.041	0.0GlyXaa: 0.0 ± 0.0
His	2.316HisAla: 2.316 ± 0.037	0.253HisCys: 0.253 ± 0.012	1.309HisAsp: 1.309 ± 0.027	1.019HisGlu: 1.019 ± 0.029	0.836HisPhe: 0.836 ± 0.024	1.838HisGly: 1.838 ± 0.04	0.562HisHis: 0.562 ± 0.019	0.981HisIle: 0.981 ± 0.025	0.58HisLys: 0.58 ± 0.018	2.217HisLeu: 2.217 ± 0.038	0.585HisMet: 0.585 ± 0.019	0.471HisAsn: 0.471 ± 0.019	1.334HisPro: 1.334 ± 0.03	0.596HisGln: 0.596 ± 0.019	1.355HisArg: 1.355 ± 0.031	1.026HisSer: 1.026 ± 0.026	0.84HisThr: 0.84 ± 0.023	1.568HisVal: 1.568 ± 0.031	0.344HisTrp: 0.344 ± 0.015	0.51HisTyr: 0.51 ± 0.018	0.0HisXaa: 0.0 ± 0.0
Ile	7.125IleAla: 7.125 ± 0.076	0.652IleCys: 0.652 ± 0.019	3.472IleAsp: 3.472 ± 0.051	3.369IleGlu: 3.369 ± 0.052	1.842IlePhe: 1.842 ± 0.041	4.868IleGly: 4.868 ± 0.066	0.898IleHis: 0.898 ± 0.023	2.281IleIle: 2.281 ± 0.042	1.511IleLys: 1.511 ± 0.031	5.021IleLeu: 5.021 ± 0.068	1.115IleMet: 1.115 ± 0.028	1.408IleAsn: 1.408 ± 0.031	2.493IlePro: 2.493 ± 0.047	1.251IleGln: 1.251 ± 0.028	3.276IleArg: 3.276 ± 0.045	3.219IleSer: 3.219 ± 0.056	3.143IleThr: 3.143 ± 0.047	3.691IleVal: 3.691 ± 0.056	0.764IleTrp: 0.764 ± 0.021	1.208IleTyr: 1.208 ± 0.031	0.0IleXaa: 0.0 ± 0.0
Lys	3.839LysAla: 3.839 ± 0.055	0.19LysCys: 0.19 ± 0.011	1.828LysAsp: 1.828 ± 0.037	1.492LysGlu: 1.492 ± 0.034	0.932LysPhe: 0.932 ± 0.026	2.754LysGly: 2.754 ± 0.04	0.605LysHis: 0.605 ± 0.021	1.717LysIle: 1.717 ± 0.034	1.161LysLys: 1.161 ± 0.029	2.975LysLeu: 2.975 ± 0.054	0.911LysMet: 0.911 ± 0.025	0.8LysAsn: 0.8 ± 0.024	1.766LysPro: 1.766 ± 0.037	0.924LysGln: 0.924 ± 0.027	2.212LysArg: 2.212 ± 0.04	1.943LysSer: 1.943 ± 0.035	2.091LysThr: 2.091 ± 0.034	2.395LysVal: 2.395 ± 0.046	0.37LysTrp: 0.37 ± 0.015	0.64LysTyr: 0.64 ± 0.021	0.0LysXaa: 0.0 ± 0.0
Leu	12.568LeuAla: 12.568 ± 0.11	1.06LeuCys: 1.06 ± 0.029	6.06LeuAsp: 6.06 ± 0.07	5.105LeuGlu: 5.105 ± 0.058	3.616LeuPhe: 3.616 ± 0.065	8.595LeuGly: 8.595 ± 0.085	1.947LeuHis: 1.947 ± 0.037	5.562LeuIle: 5.562 ± 0.071	3.216LeuLys: 3.216 ± 0.049	9.456LeuLeu: 9.456 ± 0.099	2.911LeuMet: 2.911 ± 0.046	2.876LeuAsn: 2.876 ± 0.049	5.573LeuPro: 5.573 ± 0.061	3.075LeuGln: 3.075 ± 0.045	7.35LeuArg: 7.35 ± 0.088	7.38LeuSer: 7.38 ± 0.084	6.252LeuThr: 6.252 ± 0.071	6.909LeuVal: 6.909 ± 0.071	1.331LeuTrp: 1.331 ± 0.034	1.998LeuTyr: 1.998 ± 0.035	0.0LeuXaa: 0.0 ± 0.0
Met	3.494MetAla: 3.494 ± 0.046	0.201MetCys: 0.201 ± 0.011	1.462MetAsp: 1.462 ± 0.031	1.289MetGlu: 1.289 ± 0.032	0.867MetPhe: 0.867 ± 0.028	2.314MetGly: 2.314 ± 0.046	0.51MetHis: 0.51 ± 0.018	1.696MetIle: 1.696 ± 0.035	1.078MetLys: 1.078 ± 0.026	2.805MetLeu: 2.805 ± 0.048	0.856MetMet: 0.856 ± 0.028	0.942MetAsn: 0.942 ± 0.025	1.622MetPro: 1.622 ± 0.029	1.074MetGln: 1.074 ± 0.026	1.95MetArg: 1.95 ± 0.037	1.901MetSer: 1.901 ± 0.032	2.275MetThr: 2.275 ± 0.039	1.921MetVal: 1.921 ± 0.036	0.222MetTrp: 0.222 ± 0.011	0.358MetTyr: 0.358 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	3.205AsnAla: 3.205 ± 0.043	0.245AsnCys: 0.245 ± 0.012	1.505AsnAsp: 1.505 ± 0.032	1.133AsnGlu: 1.133 ± 0.025	0.96AsnPhe: 0.96 ± 0.021	2.399AsnGly: 2.399 ± 0.04	0.51AsnHis: 0.51 ± 0.018	1.478AsnIle: 1.478 ± 0.035	0.688AsnLys: 0.688 ± 0.024	2.642AsnLeu: 2.642 ± 0.038	0.758AsnMet: 0.758 ± 0.02	0.678AsnAsn: 0.678 ± 0.024	1.813AsnPro: 1.813 ± 0.039	0.713AsnGln: 0.713 ± 0.023	1.778AsnArg: 1.778 ± 0.035	1.251AsnSer: 1.251 ± 0.03	1.462AsnThr: 1.462 ± 0.034	1.844AsnVal: 1.844 ± 0.035	0.441AsnTrp: 0.441 ± 0.017	0.617AsnTyr: 0.617 ± 0.019	0.0AsnXaa: 0.0 ± 0.0
Pro	5.355ProAla: 5.355 ± 0.061	0.381ProCys: 0.381 ± 0.014	3.882ProAsp: 3.882 ± 0.055	3.813ProGlu: 3.813 ± 0.055	1.935ProPhe: 1.935 ± 0.037	4.335ProGly: 4.335 ± 0.059	1.033ProHis: 1.033 ± 0.023	2.261ProIle: 2.261 ± 0.041	1.689ProLys: 1.689 ± 0.034	4.795ProLeu: 4.795 ± 0.071	1.348ProMet: 1.348 ± 0.029	1.307ProAsn: 1.307 ± 0.032	2.233ProPro: 2.233 ± 0.043	1.8ProGln: 1.8 ± 0.034	2.73ProArg: 2.73 ± 0.045	2.664ProSer: 2.664 ± 0.046	2.42ProThr: 2.42 ± 0.036	4.147ProVal: 4.147 ± 0.054	0.655ProTrp: 0.655 ± 0.022	1.16ProTyr: 1.16 ± 0.026	0.0ProXaa: 0.0 ± 0.0
Gln	4.079GlnAla: 4.079 ± 0.051	0.209GlnCys: 0.209 ± 0.009	1.891GlnAsp: 1.891 ± 0.036	1.6GlnGlu: 1.6 ± 0.03	1.132GlnPhe: 1.132 ± 0.028	2.752GlnGly: 2.752 ± 0.039	0.678GlnHis: 0.678 ± 0.022	2.302GlnIle: 2.302 ± 0.04	1.15GlnLys: 1.15 ± 0.028	3.021GlnLeu: 3.021 ± 0.047	1.152GlnMet: 1.152 ± 0.026	1.025GlnAsn: 1.025 ± 0.027	1.657GlnPro: 1.657 ± 0.035	1.207GlnGln: 1.207 ± 0.034	2.355GlnArg: 2.355 ± 0.044	2.051GlnSer: 2.051 ± 0.037	2.084GlnThr: 2.084 ± 0.038	2.402GlnVal: 2.402 ± 0.04	0.428GlnTrp: 0.428 ± 0.018	0.604GlnTyr: 0.604 ± 0.018	0.0GlnXaa: 0.0 ± 0.0
Arg	7.83ArgAla: 7.83 ± 0.089	0.526ArgCys: 0.526 ± 0.021	4.402ArgAsp: 4.402 ± 0.063	3.432ArgGlu: 3.432 ± 0.05	2.623ArgPhe: 2.623 ± 0.036	4.556ArgGly: 4.556 ± 0.059	1.573ArgHis: 1.573 ± 0.032	3.967ArgIle: 3.967 ± 0.054	2.329ArgLys: 2.329 ± 0.041	7.194ArgLeu: 7.194 ± 0.075	2.026ArgMet: 2.026 ± 0.033	1.804ArgAsn: 1.804 ± 0.038	3.137ArgPro: 3.137 ± 0.048	2.36ArgGln: 2.36 ± 0.044	4.971ArgArg: 4.971 ± 0.071	3.467ArgSer: 3.467 ± 0.045	3.204ArgThr: 3.204 ± 0.045	4.615ArgVal: 4.615 ± 0.059	0.932ArgTrp: 0.932 ± 0.023	1.542ArgTyr: 1.542 ± 0.029	0.0ArgXaa: 0.0 ± 0.0
Ser	6.274SerAla: 6.274 ± 0.057	0.519SerCys: 0.519 ± 0.02	3.633SerAsp: 3.633 ± 0.054	3.148SerGlu: 3.148 ± 0.048	2.308SerPhe: 2.308 ± 0.039	5.691SerGly: 5.691 ± 0.062	1.158SerHis: 1.158 ± 0.025	2.68SerIle: 2.68 ± 0.043	1.612SerLys: 1.612 ± 0.035	5.377SerLeu: 5.377 ± 0.058	1.532SerMet: 1.532 ± 0.03	1.47SerAsn: 1.47 ± 0.032	2.55SerPro: 2.55 ± 0.046	1.773SerGln: 1.773 ± 0.035	3.399SerArg: 3.399 ± 0.052	2.921SerSer: 2.921 ± 0.049	2.663SerThr: 2.663 ± 0.041	4.153SerVal: 4.153 ± 0.053	0.762SerTrp: 0.762 ± 0.021	1.413SerTyr: 1.413 ± 0.03	0.0SerXaa: 0.0 ± 0.0
Thr	6.546ThrAla: 6.546 ± 0.079	0.513ThrCys: 0.513 ± 0.018	3.234ThrAsp: 3.234 ± 0.049	2.942ThrGlu: 2.942 ± 0.043	2.091ThrPhe: 2.091 ± 0.041	5.513ThrGly: 5.513 ± 0.069	1.175ThrHis: 1.175 ± 0.027	2.796ThrIle: 2.796 ± 0.043	1.534ThrLys: 1.534 ± 0.03	6.611ThrLeu: 6.611 ± 0.073	1.356ThrMet: 1.356 ± 0.033	1.364ThrAsn: 1.364 ± 0.031	3.531ThrPro: 3.531 ± 0.048	1.82ThrGln: 1.82 ± 0.036	3.505ThrArg: 3.505 ± 0.051	3.052ThrSer: 3.052 ± 0.045	3.059ThrThr: 3.059 ± 0.051	4.186ThrVal: 4.186 ± 0.055	0.66ThrTrp: 0.66 ± 0.022	1.285ThrTyr: 1.285 ± 0.03	0.0ThrXaa: 0.0 ± 0.0
Val	8.69ValAla: 8.69 ± 0.082	0.666ValCys: 0.666 ± 0.021	3.984ValAsp: 3.984 ± 0.051	3.963ValGlu: 3.963 ± 0.051	2.872ValPhe: 2.872 ± 0.041	5.412ValGly: 5.412 ± 0.069	1.315ValHis: 1.315 ± 0.03	4.271ValIle: 4.271 ± 0.06	2.101ValLys: 2.101 ± 0.04	7.662ValLeu: 7.662 ± 0.088	2.25ValMet: 2.25 ± 0.038	1.915ValAsn: 1.915 ± 0.036	3.542ValPro: 3.542 ± 0.047	2.309ValGln: 2.309 ± 0.041	4.22ValArg: 4.22 ± 0.048	4.409ValSer: 4.409 ± 0.056	4.792ValThr: 4.792 ± 0.061	5.663ValVal: 5.663 ± 0.069	0.962ValTrp: 0.962 ± 0.03	1.463ValTyr: 1.463 ± 0.032	0.0ValXaa: 0.0 ± 0.0
Trp	1.322TrpAla: 1.322 ± 0.029	0.153TrpCys: 0.153 ± 0.009	0.785TrpAsp: 0.785 ± 0.021	0.597TrpGlu: 0.597 ± 0.019	0.534TrpPhe: 0.534 ± 0.018	0.994TrpGly: 0.994 ± 0.03	0.338TrpHis: 0.338 ± 0.014	0.724TrpIle: 0.724 ± 0.022	0.458TrpLys: 0.458 ± 0.017	1.589TrpLeu: 1.589 ± 0.034	0.439TrpMet: 0.439 ± 0.018	0.449TrpAsn: 0.449 ± 0.016	0.721TrpPro: 0.721 ± 0.026	0.629TrpGln: 0.629 ± 0.02	1.094TrpArg: 1.094 ± 0.027	0.85TrpSer: 0.85 ± 0.022	0.791TrpThr: 0.791 ± 0.021	0.905TrpVal: 0.905 ± 0.024	0.216TrpTrp: 0.216 ± 0.011	0.261TrpTyr: 0.261 ± 0.012	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.537TyrAla: 2.537 ± 0.038	0.222TyrCys: 0.222 ± 0.012	1.598TyrAsp: 1.598 ± 0.033	1.196TyrGlu: 1.196 ± 0.03	0.906TyrPhe: 0.906 ± 0.024	2.102TyrGly: 2.102 ± 0.037	0.469TyrHis: 0.469 ± 0.021	0.961TyrIle: 0.961 ± 0.026	0.583TyrLys: 0.583 ± 0.022	2.285TyrLeu: 2.285 ± 0.041	0.493TyrMet: 0.493 ± 0.018	0.602TyrAsn: 0.602 ± 0.021	1.074TyrPro: 1.074 ± 0.029	0.693TyrGln: 0.693 ± 0.023	1.528TyrArg: 1.528 ± 0.03	1.163TyrSer: 1.163 ± 0.029	1.167TyrThr: 1.167 ± 0.024	1.521TyrVal: 1.521 ± 0.03	0.339TyrTrp: 0.339 ± 0.017	0.554TyrTyr: 0.554 ± 0.021	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5603 proteins (1590982 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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