Amino acid dipepetide frequency for Agromyces protaetiae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
21.823AlaAla: 21.823 ± 0.266
0.645AlaCys: 0.645 ± 0.025
8.958AlaAsp: 8.958 ± 0.107
8.746AlaGlu: 8.746 ± 0.115
4.404AlaPhe: 4.404 ± 0.069
12.82AlaGly: 12.82 ± 0.121
2.511AlaHis: 2.511 ± 0.054
6.437AlaIle: 6.437 ± 0.089
2.957AlaLys: 2.957 ± 0.061
14.517AlaLeu: 14.517 ± 0.16
2.419AlaMet: 2.419 ± 0.049
2.45AlaAsn: 2.45 ± 0.053
7.073AlaPro: 7.073 ± 0.12
3.44AlaGln: 3.44 ± 0.059
10.116AlaArg: 10.116 ± 0.147
8.782AlaSer: 8.782 ± 0.112
7.505AlaThr: 7.505 ± 0.105
11.973AlaVal: 11.973 ± 0.135
2.03AlaTrp: 2.03 ± 0.046
2.308AlaTyr: 2.308 ± 0.05
0.0AlaXaa: 0.0 ± 0.0
Cys
0.577CysAla: 0.577 ± 0.025
0.053CysCys: 0.053 ± 0.008
0.299CysAsp: 0.299 ± 0.021
0.242CysGlu: 0.242 ± 0.017
0.155CysPhe: 0.155 ± 0.012
0.538CysGly: 0.538 ± 0.025
0.085CysHis: 0.085 ± 0.008
0.165CysIle: 0.165 ± 0.012
0.066CysLys: 0.066 ± 0.008
0.401CysLeu: 0.401 ± 0.019
0.068CysMet: 0.068 ± 0.008
0.087CysAsn: 0.087 ± 0.009
0.292CysPro: 0.292 ± 0.018
0.096CysGln: 0.096 ± 0.009
0.337CysArg: 0.337 ± 0.021
0.362CysSer: 0.362 ± 0.021
0.304CysThr: 0.304 ± 0.018
0.387CysVal: 0.387 ± 0.019
0.059CysTrp: 0.059 ± 0.007
0.074CysTyr: 0.074 ± 0.009
0.0CysXaa: 0.0 ± 0.0
Asp
9.796AspAla: 9.796 ± 0.127
0.226AspCys: 0.226 ± 0.018
4.565AspAsp: 4.565 ± 0.077
4.845AspGlu: 4.845 ± 0.063
1.732AspPhe: 1.732 ± 0.04
6.296AspGly: 6.296 ± 0.093
1.115AspHis: 1.115 ± 0.035
2.078AspIle: 2.078 ± 0.048
0.844AspLys: 0.844 ± 0.035
6.5AspLeu: 6.5 ± 0.088
0.615AspMet: 0.615 ± 0.027
0.775AspAsn: 0.775 ± 0.029
4.388AspPro: 4.388 ± 0.065
1.424AspGln: 1.424 ± 0.036
4.933AspArg: 4.933 ± 0.089
2.434AspSer: 2.434 ± 0.045
2.588AspThr: 2.588 ± 0.053
5.79AspVal: 5.79 ± 0.075
0.981AspTrp: 0.981 ± 0.03
1.184AspTyr: 1.184 ± 0.036
0.0AspXaa: 0.0 ± 0.0
Glu
7.888GluAla: 7.888 ± 0.098
0.248GluCys: 0.248 ± 0.016
2.417GluAsp: 2.417 ± 0.052
2.793GluGlu: 2.793 ± 0.059
1.95GluPhe: 1.95 ± 0.045
4.179GluGly: 4.179 ± 0.068
1.674GluHis: 1.674 ± 0.044
2.799GluIle: 2.799 ± 0.053
1.108GluLys: 1.108 ± 0.037
6.848GluLeu: 6.848 ± 0.093
0.783GluMet: 0.783 ± 0.029
1.03GluAsn: 1.03 ± 0.032
3.426GluPro: 3.426 ± 0.063
2.199GluGln: 2.199 ± 0.057
5.892GluArg: 5.892 ± 0.098
2.962GluSer: 2.962 ± 0.061
3.276GluThr: 3.276 ± 0.058
4.755GluVal: 4.755 ± 0.075
0.987GluTrp: 0.987 ± 0.036
1.202GluTyr: 1.202 ± 0.035
0.0GluXaa: 0.0 ± 0.0
Phe
4.82PheAla: 4.82 ± 0.074
0.165PheCys: 0.165 ± 0.012
2.524PheAsp: 2.524 ± 0.05
2.067PheGlu: 2.067 ± 0.05
1.018PhePhe: 1.018 ± 0.034
3.565PheGly: 3.565 ± 0.061
0.528PheHis: 0.528 ± 0.026
1.172PheIle: 1.172 ± 0.038
0.479PheLys: 0.479 ± 0.024
2.816PheLeu: 2.816 ± 0.057
0.402PheMet: 0.402 ± 0.021
0.663PheAsn: 0.663 ± 0.024
1.433PhePro: 1.433 ± 0.039
0.732PheGln: 0.732 ± 0.027
1.885PheArg: 1.885 ± 0.044
1.562PheSer: 1.562 ± 0.043
2.149PheThr: 2.149 ± 0.049
3.003PheVal: 3.003 ± 0.063
0.509PheTrp: 0.509 ± 0.027
0.601PheTyr: 0.601 ± 0.028
0.0PheXaa: 0.0 ± 0.0
Gly
11.844GlyAla: 11.844 ± 0.143
0.569GlyCys: 0.569 ± 0.023
5.464GlyAsp: 5.464 ± 0.077
5.333GlyGlu: 5.333 ± 0.074
3.489GlyPhe: 3.489 ± 0.062
8.272GlyGly: 8.272 ± 0.125
1.707GlyHis: 1.707 ± 0.039
4.538GlyIle: 4.538 ± 0.082
2.121GlyLys: 2.121 ± 0.055
8.857GlyLeu: 8.857 ± 0.102
1.703GlyMet: 1.703 ± 0.043
1.579GlyAsn: 1.579 ± 0.039
3.949GlyPro: 3.949 ± 0.065
2.246GlyGln: 2.246 ± 0.051
6.705GlyArg: 6.705 ± 0.092
5.283GlySer: 5.283 ± 0.086
5.34GlyThr: 5.34 ± 0.077
8.288GlyVal: 8.288 ± 0.096
1.677GlyTrp: 1.677 ± 0.042
2.271GlyTyr: 2.271 ± 0.054
0.0GlyXaa: 0.0 ± 0.0
His
2.394HisAla: 2.394 ± 0.054
0.092HisCys: 0.092 ± 0.008
1.386HisAsp: 1.386 ± 0.037
1.203HisGlu: 1.203 ± 0.04
0.563HisPhe: 0.563 ± 0.023
1.985HisGly: 1.985 ± 0.047
0.46HisHis: 0.46 ± 0.025
0.609HisIle: 0.609 ± 0.024
0.23HisLys: 0.23 ± 0.016
1.917HisLeu: 1.917 ± 0.052
0.255HisMet: 0.255 ± 0.014
0.3HisAsn: 0.3 ± 0.017
1.517HisPro: 1.517 ± 0.043
0.403HisGln: 0.403 ± 0.02
1.539HisArg: 1.539 ± 0.041
0.909HisSer: 0.909 ± 0.028
0.885HisThr: 0.885 ± 0.031
1.647HisVal: 1.647 ± 0.043
0.27HisTrp: 0.27 ± 0.017
0.391HisTyr: 0.391 ± 0.02
0.0HisXaa: 0.0 ± 0.0
Ile
7.155IleAla: 7.155 ± 0.088
0.188IleCys: 0.188 ± 0.014
3.389IleAsp: 3.389 ± 0.064
2.939IleGlu: 2.939 ± 0.058
1.058IlePhe: 1.058 ± 0.034
4.523IleGly: 4.523 ± 0.081
0.641IleHis: 0.641 ± 0.027
1.514IleIle: 1.514 ± 0.047
0.7IleLys: 0.7 ± 0.03
3.47IleLeu: 3.47 ± 0.066
0.567IleMet: 0.567 ± 0.025
0.672IleAsn: 0.672 ± 0.027
2.24IlePro: 2.24 ± 0.045
0.857IleGln: 0.857 ± 0.03
2.694IleArg: 2.694 ± 0.055
2.048IleSer: 2.048 ± 0.039
2.413IleThr: 2.413 ± 0.05
4.875IleVal: 4.875 ± 0.07
0.495IleTrp: 0.495 ± 0.022
0.638IleTyr: 0.638 ± 0.025
0.0IleXaa: 0.0 ± 0.0
Lys
2.492LysAla: 2.492 ± 0.049
0.065LysCys: 0.065 ± 0.007
0.918LysAsp: 0.918 ± 0.036
0.849LysGlu: 0.849 ± 0.033
0.488LysPhe: 0.488 ± 0.022
1.491LysGly: 1.491 ± 0.045
0.453LysHis: 0.453 ± 0.02
0.878LysIle: 0.878 ± 0.033
0.658LysLys: 0.658 ± 0.034
2.051LysLeu: 2.051 ± 0.049
0.334LysMet: 0.334 ± 0.018
0.462LysAsn: 0.462 ± 0.022
1.262LysPro: 1.262 ± 0.04
0.656LysGln: 0.656 ± 0.028
1.643LysArg: 1.643 ± 0.044
1.146LysSer: 1.146 ± 0.036
1.264LysThr: 1.264 ± 0.044
1.647LysVal: 1.647 ± 0.043
0.267LysTrp: 0.267 ± 0.017
0.425LysTyr: 0.425 ± 0.023
0.0LysXaa: 0.0 ± 0.0
Leu
15.967LeuAla: 15.967 ± 0.168
0.436LeuCys: 0.436 ± 0.02
7.258LeuAsp: 7.258 ± 0.089
5.622LeuGlu: 5.622 ± 0.078
2.748LeuPhe: 2.748 ± 0.055
9.31LeuGly: 9.31 ± 0.106
1.738LeuHis: 1.738 ± 0.041
3.88LeuIle: 3.88 ± 0.075
1.8LeuLys: 1.8 ± 0.051
9.616LeuLeu: 9.616 ± 0.132
1.297LeuMet: 1.297 ± 0.036
1.606LeuAsn: 1.606 ± 0.042
5.412LeuPro: 5.412 ± 0.084
2.297LeuGln: 2.297 ± 0.05
6.982LeuArg: 6.982 ± 0.091
5.299LeuSer: 5.299 ± 0.071
5.511LeuThr: 5.511 ± 0.07
10.347LeuVal: 10.347 ± 0.116
1.251LeuTrp: 1.251 ± 0.036
1.499LeuTyr: 1.499 ± 0.045
0.0LeuXaa: 0.0 ± 0.0
Met
1.731MetAla: 1.731 ± 0.042
0.081MetCys: 0.081 ± 0.009
0.622MetAsp: 0.622 ± 0.024
0.507MetGlu: 0.507 ± 0.022
0.441MetPhe: 0.441 ± 0.024
1.089MetGly: 1.089 ± 0.034
0.308MetHis: 0.308 ± 0.018
0.606MetIle: 0.606 ± 0.025
0.362MetLys: 0.362 ± 0.019
1.641MetLeu: 1.641 ± 0.041
0.227MetMet: 0.227 ± 0.021
0.391MetAsn: 0.391 ± 0.019
1.121MetPro: 1.121 ± 0.034
0.466MetGln: 0.466 ± 0.02
1.223MetArg: 1.223 ± 0.036
1.339MetSer: 1.339 ± 0.04
1.425MetThr: 1.425 ± 0.036
1.028MetVal: 1.028 ± 0.034
0.175MetTrp: 0.175 ± 0.012
0.227MetTyr: 0.227 ± 0.015
0.0MetXaa: 0.0 ± 0.0
Asn
2.422AsnAla: 2.422 ± 0.05
0.104AsnCys: 0.104 ± 0.01
1.076AsnAsp: 1.076 ± 0.037
0.948AsnGlu: 0.948 ± 0.034
0.585AsnPhe: 0.585 ± 0.029
1.846AsnGly: 1.846 ± 0.051
0.32AsnHis: 0.32 ± 0.018
0.713AsnIle: 0.713 ± 0.028
0.328AsnLys: 0.328 ± 0.017
1.778AsnLeu: 1.778 ± 0.042
0.24AsnMet: 0.24 ± 0.015
0.405AsnAsn: 0.405 ± 0.025
1.545AsnPro: 1.545 ± 0.042
0.491AsnGln: 0.491 ± 0.024
1.23AsnArg: 1.23 ± 0.033
0.861AsnSer: 0.861 ± 0.031
1.042AsnThr: 1.042 ± 0.036
1.532AsnVal: 1.532 ± 0.039
0.319AsnTrp: 0.319 ± 0.019
0.384AsnTyr: 0.384 ± 0.019
0.0AsnXaa: 0.0 ± 0.0
Pro
7.664ProAla: 7.664 ± 0.1
0.172ProCys: 0.172 ± 0.014
4.175ProAsp: 4.175 ± 0.073
3.909ProGlu: 3.909 ± 0.068
1.79ProPhe: 1.79 ± 0.042
5.262ProGly: 5.262 ± 0.084
1.036ProHis: 1.036 ± 0.035
2.192ProIle: 2.192 ± 0.047
1.146ProLys: 1.146 ± 0.041
4.811ProLeu: 4.811 ± 0.076
0.74ProMet: 0.74 ± 0.03
1.132ProAsn: 1.132 ± 0.038
2.548ProPro: 2.548 ± 0.064
1.353ProGln: 1.353 ± 0.044
3.603ProArg: 3.603 ± 0.069
3.143ProSer: 3.143 ± 0.064
3.519ProThr: 3.519 ± 0.072
5.241ProVal: 5.241 ± 0.091
0.912ProTrp: 0.912 ± 0.031
1.054ProTyr: 1.054 ± 0.034
0.0ProXaa: 0.0 ± 0.0
Gln
3.487GlnAla: 3.487 ± 0.065
0.086GlnCys: 0.086 ± 0.009
0.964GlnAsp: 0.964 ± 0.03
1.084GlnGlu: 1.084 ± 0.036
0.88GlnPhe: 0.88 ± 0.031
1.973GlnGly: 1.973 ± 0.048
0.54GlnHis: 0.54 ± 0.023
1.266GlnIle: 1.266 ± 0.037
0.621GlnLys: 0.621 ± 0.02
2.842GlnLeu: 2.842 ± 0.051
0.37GlnMet: 0.37 ± 0.018
0.599GlnAsn: 0.599 ± 0.029
1.42GlnPro: 1.42 ± 0.041
1.034GlnGln: 1.034 ± 0.035
2.081GlnArg: 2.081 ± 0.06
1.399GlnSer: 1.399 ± 0.039
1.482GlnThr: 1.482 ± 0.038
2.149GlnVal: 2.149 ± 0.046
0.383GlnTrp: 0.383 ± 0.02
0.542GlnTyr: 0.542 ± 0.023
0.0GlnXaa: 0.0 ± 0.0
Arg
9.928ArgAla: 9.928 ± 0.119
0.336ArgCys: 0.336 ± 0.019
4.324ArgAsp: 4.324 ± 0.063
4.497ArgGlu: 4.497 ± 0.076
2.646ArgPhe: 2.646 ± 0.048
5.753ArgGly: 5.753 ± 0.083
1.537ArgHis: 1.537 ± 0.042
3.676ArgIle: 3.676 ± 0.062
1.406ArgLys: 1.406 ± 0.046
7.796ArgLeu: 7.796 ± 0.111
1.518ArgMet: 1.518 ± 0.037
1.284ArgAsn: 1.284 ± 0.035
3.969ArgPro: 3.969 ± 0.073
1.767ArgGln: 1.767 ± 0.037
7.199ArgArg: 7.199 ± 0.121
4.172ArgSer: 4.172 ± 0.073
4.189ArgThr: 4.189 ± 0.07
6.224ArgVal: 6.224 ± 0.09
1.106ArgTrp: 1.106 ± 0.036
1.589ArgTyr: 1.589 ± 0.042
0.0ArgXaa: 0.0 ± 0.0
Ser
7.354SerAla: 7.354 ± 0.093
0.283SerCys: 0.283 ± 0.019
3.176SerAsp: 3.176 ± 0.056
2.767SerGlu: 2.767 ± 0.05
1.846SerPhe: 1.846 ± 0.043
5.976SerGly: 5.976 ± 0.076
0.953SerHis: 0.953 ± 0.034
2.546SerIle: 2.546 ± 0.052
1.183SerLys: 1.183 ± 0.038
5.213SerLeu: 5.213 ± 0.073
0.986SerMet: 0.986 ± 0.031
1.103SerAsn: 1.103 ± 0.036
3.286SerPro: 3.286 ± 0.07
1.318SerGln: 1.318 ± 0.036
3.888SerArg: 3.888 ± 0.064
3.283SerSer: 3.283 ± 0.066
3.542SerThr: 3.542 ± 0.077
4.73SerVal: 4.73 ± 0.072
0.923SerTrp: 0.923 ± 0.029
1.107SerTyr: 1.107 ± 0.034
0.0SerXaa: 0.0 ± 0.0
Thr
7.735ThrAla: 7.735 ± 0.092
0.264ThrCys: 0.264 ± 0.015
3.366ThrAsp: 3.366 ± 0.058
2.868ThrGlu: 2.868 ± 0.054
1.828ThrPhe: 1.828 ± 0.048
5.844ThrGly: 5.844 ± 0.09
1.034ThrHis: 1.034 ± 0.029
2.75ThrIle: 2.75 ± 0.06
1.165ThrLys: 1.165 ± 0.031
5.456ThrLeu: 5.456 ± 0.076
0.805ThrMet: 0.805 ± 0.03
1.095ThrAsn: 1.095 ± 0.038
3.789ThrPro: 3.789 ± 0.07
1.259ThrGln: 1.259 ± 0.04
3.631ThrArg: 3.631 ± 0.064
3.435ThrSer: 3.435 ± 0.066
3.637ThrThr: 3.637 ± 0.08
5.496ThrVal: 5.496 ± 0.092
0.88ThrTrp: 0.88 ± 0.032
1.061ThrTyr: 1.061 ± 0.037
0.0ThrXaa: 0.0 ± 0.0
Val
12.72ValAla: 12.72 ± 0.144
0.443ValCys: 0.443 ± 0.019
6.159ValAsp: 6.159 ± 0.094
5.424ValGlu: 5.424 ± 0.079
3.165ValPhe: 3.165 ± 0.057
7.598ValGly: 7.598 ± 0.094
1.701ValHis: 1.701 ± 0.039
3.865ValIle: 3.865 ± 0.058
1.66ValLys: 1.66 ± 0.048
9.506ValLeu: 9.506 ± 0.128
1.18ValMet: 1.18 ± 0.036
1.676ValAsn: 1.676 ± 0.048
5.006ValPro: 5.006 ± 0.073
2.183ValGln: 2.183 ± 0.044
6.415ValArg: 6.415 ± 0.082
5.102ValSer: 5.102 ± 0.073
5.284ValThr: 5.284 ± 0.094
9.807ValVal: 9.807 ± 0.128
1.203ValTrp: 1.203 ± 0.04
1.57ValTyr: 1.57 ± 0.043
0.0ValXaa: 0.0 ± 0.0
Trp
1.751TrpAla: 1.751 ± 0.042
0.087TrpCys: 0.087 ± 0.009
0.695TrpAsp: 0.695 ± 0.026
0.632TrpGlu: 0.632 ± 0.027
0.61TrpPhe: 0.61 ± 0.024
1.069TrpGly: 1.069 ± 0.034
0.327TrpHis: 0.327 ± 0.018
0.825TrpIle: 0.825 ± 0.028
0.305TrpLys: 0.305 ± 0.015
1.777TrpLeu: 1.777 ± 0.045
0.301TrpMet: 0.301 ± 0.018
0.482TrpAsn: 0.482 ± 0.02
0.743TrpPro: 0.743 ± 0.027
0.493TrpGln: 0.493 ± 0.023
1.249TrpArg: 1.249 ± 0.038
0.971TrpSer: 0.971 ± 0.033
0.932TrpThr: 0.932 ± 0.031
1.187TrpVal: 1.187 ± 0.034
0.41TrpTrp: 0.41 ± 0.021
0.311TrpTyr: 0.311 ± 0.019
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.367TyrAla: 2.367 ± 0.046
0.104TyrCys: 0.104 ± 0.011
1.375TyrAsp: 1.375 ± 0.038
1.143TyrGlu: 1.143 ± 0.039
0.695TyrPhe: 0.695 ± 0.025
1.848TyrGly: 1.848 ± 0.046
0.288TyrHis: 0.288 ± 0.017
0.566TyrIle: 0.566 ± 0.025
0.31TyrLys: 0.31 ± 0.019
2.059TyrLeu: 2.059 ± 0.049
0.198TyrMet: 0.198 ± 0.014
0.38TyrAsn: 0.38 ± 0.018
0.981TyrPro: 0.981 ± 0.032
0.487TyrGln: 0.487 ± 0.026
1.675TyrArg: 1.675 ± 0.05
0.971TyrSer: 0.971 ± 0.034
1.109TyrThr: 1.109 ± 0.036
1.562TyrVal: 1.562 ± 0.039
0.32TyrTrp: 0.32 ± 0.017
0.41TyrTyr: 0.41 ± 0.023
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3136 proteins (1040253 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski