Amino acid dipepetide frequency for Sodalis phage phiSG1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
10.95AlaAla: 10.95 ± 1.248
1.173AlaCys: 1.173 ± 0.312
4.771AlaAsp: 4.771 ± 0.688
8.135AlaGlu: 8.135 ± 0.911
3.911AlaPhe: 3.911 ± 0.502
7.118AlaGly: 7.118 ± 1.168
2.19AlaHis: 2.19 ± 0.433
4.928AlaIle: 4.928 ± 0.679
4.302AlaLys: 4.302 ± 0.633
9.934AlaLeu: 9.934 ± 0.973
2.894AlaMet: 2.894 ± 0.462
3.598AlaAsn: 3.598 ± 0.65
3.989AlaPro: 3.989 ± 0.845
5.944AlaGln: 5.944 ± 0.854
6.961AlaArg: 6.961 ± 0.935
5.397AlaSer: 5.397 ± 0.587
6.257AlaThr: 6.257 ± 0.728
7.822AlaVal: 7.822 ± 0.743
1.877AlaTrp: 1.877 ± 0.407
2.659AlaTyr: 2.659 ± 0.439
0.0AlaXaa: 0.0 ± 0.0
Cys
1.173CysAla: 1.173 ± 0.343
0.156CysCys: 0.156 ± 0.097
1.095CysAsp: 1.095 ± 0.295
0.548CysGlu: 0.548 ± 0.314
0.704CysPhe: 0.704 ± 0.169
0.86CysGly: 0.86 ± 0.228
0.469CysHis: 0.469 ± 0.178
0.626CysIle: 0.626 ± 0.203
0.86CysLys: 0.86 ± 0.316
1.173CysLeu: 1.173 ± 0.359
0.391CysMet: 0.391 ± 0.168
0.235CysAsn: 0.235 ± 0.127
0.469CysPro: 0.469 ± 0.179
0.313CysGln: 0.313 ± 0.147
0.86CysArg: 0.86 ± 0.257
0.86CysSer: 0.86 ± 0.263
0.313CysThr: 0.313 ± 0.15
0.86CysVal: 0.86 ± 0.291
0.0CysTrp: 0.0 ± 0.0
0.235CysTyr: 0.235 ± 0.14
0.0CysXaa: 0.0 ± 0.0
Asp
8.604AspAla: 8.604 ± 0.981
0.939AspCys: 0.939 ± 0.248
3.833AspAsp: 3.833 ± 0.606
3.285AspGlu: 3.285 ± 0.492
1.877AspPhe: 1.877 ± 0.413
4.849AspGly: 4.849 ± 0.603
0.939AspHis: 0.939 ± 0.28
4.771AspIle: 4.771 ± 0.763
2.19AspLys: 2.19 ± 0.394
3.911AspLeu: 3.911 ± 0.601
2.112AspMet: 2.112 ± 0.406
2.659AspAsn: 2.659 ± 0.481
2.268AspPro: 2.268 ± 0.516
1.486AspGln: 1.486 ± 0.337
2.816AspArg: 2.816 ± 0.493
2.503AspSer: 2.503 ± 0.497
2.659AspThr: 2.659 ± 0.451
3.363AspVal: 3.363 ± 0.433
1.408AspTrp: 1.408 ± 0.351
2.034AspTyr: 2.034 ± 0.518
0.0AspXaa: 0.0 ± 0.0
Glu
7.039GluAla: 7.039 ± 0.851
0.782GluCys: 0.782 ± 0.267
2.894GluAsp: 2.894 ± 0.5
4.224GluGlu: 4.224 ± 0.893
2.19GluPhe: 2.19 ± 0.465
4.693GluGly: 4.693 ± 0.771
1.33GluHis: 1.33 ± 0.321
3.911GluIle: 3.911 ± 0.626
5.788GluLys: 5.788 ± 0.717
5.944GluLeu: 5.944 ± 0.704
1.721GluMet: 1.721 ± 0.42
3.52GluAsn: 3.52 ± 0.553
2.346GluPro: 2.346 ± 0.481
4.302GluGln: 4.302 ± 0.619
3.676GluArg: 3.676 ± 0.426
3.207GluSer: 3.207 ± 0.597
3.676GluThr: 3.676 ± 0.796
4.537GluVal: 4.537 ± 0.706
0.782GluTrp: 0.782 ± 0.189
1.408GluTyr: 1.408 ± 0.283
0.0GluXaa: 0.0 ± 0.0
Phe
2.112PheAla: 2.112 ± 0.452
0.626PheCys: 0.626 ± 0.185
3.285PheAsp: 3.285 ± 0.443
2.894PheGlu: 2.894 ± 0.539
1.408PhePhe: 1.408 ± 0.443
2.972PheGly: 2.972 ± 0.36
0.939PheHis: 0.939 ± 0.277
1.721PheIle: 1.721 ± 0.358
1.799PheLys: 1.799 ± 0.345
2.425PheLeu: 2.425 ± 0.413
1.408PheMet: 1.408 ± 0.328
1.955PheAsn: 1.955 ± 0.417
1.017PhePro: 1.017 ± 0.212
1.173PheGln: 1.173 ± 0.313
1.564PheArg: 1.564 ± 0.373
2.112PheSer: 2.112 ± 0.45
2.346PheThr: 2.346 ± 0.498
2.346PheVal: 2.346 ± 0.427
0.313PheTrp: 0.313 ± 0.146
1.408PheTyr: 1.408 ± 0.326
0.0PheXaa: 0.0 ± 0.0
Gly
4.928GlyAla: 4.928 ± 0.913
1.017GlyCys: 1.017 ± 0.248
4.224GlyAsp: 4.224 ± 0.603
4.537GlyGlu: 4.537 ± 0.479
2.738GlyPhe: 2.738 ± 0.42
5.397GlyGly: 5.397 ± 0.968
1.877GlyHis: 1.877 ± 0.368
4.849GlyIle: 4.849 ± 0.638
4.458GlyLys: 4.458 ± 0.574
6.648GlyLeu: 6.648 ± 0.645
2.112GlyMet: 2.112 ± 0.385
3.05GlyAsn: 3.05 ± 0.679
1.486GlyPro: 1.486 ± 0.4
3.598GlyGln: 3.598 ± 0.636
5.319GlyArg: 5.319 ± 0.638
3.442GlySer: 3.442 ± 0.462
3.676GlyThr: 3.676 ± 0.573
4.693GlyVal: 4.693 ± 0.846
1.017GlyTrp: 1.017 ± 0.297
2.581GlyTyr: 2.581 ± 0.457
0.0GlyXaa: 0.0 ± 0.0
His
2.268HisAla: 2.268 ± 0.466
0.313HisCys: 0.313 ± 0.148
0.939HisAsp: 0.939 ± 0.27
1.564HisGlu: 1.564 ± 0.28
0.626HisPhe: 0.626 ± 0.239
1.173HisGly: 1.173 ± 0.265
0.313HisHis: 0.313 ± 0.141
1.33HisIle: 1.33 ± 0.361
0.704HisLys: 0.704 ± 0.211
2.346HisLeu: 2.346 ± 0.476
0.313HisMet: 0.313 ± 0.16
0.626HisAsn: 0.626 ± 0.229
1.173HisPro: 1.173 ± 0.31
0.939HisGln: 0.939 ± 0.273
2.034HisArg: 2.034 ± 0.657
1.095HisSer: 1.095 ± 0.341
0.86HisThr: 0.86 ± 0.256
1.564HisVal: 1.564 ± 0.312
0.548HisTrp: 0.548 ± 0.17
0.391HisTyr: 0.391 ± 0.201
0.0HisXaa: 0.0 ± 0.0
Ile
7.352IleAla: 7.352 ± 0.95
0.313IleCys: 0.313 ± 0.143
3.754IleAsp: 3.754 ± 0.606
2.346IleGlu: 2.346 ± 0.491
1.408IlePhe: 1.408 ± 0.329
3.911IleGly: 3.911 ± 0.595
1.017IleHis: 1.017 ± 0.28
2.19IleIle: 2.19 ± 0.473
3.363IleLys: 3.363 ± 0.593
2.346IleLeu: 2.346 ± 0.403
0.626IleMet: 0.626 ± 0.209
2.816IleAsn: 2.816 ± 0.45
2.816IlePro: 2.816 ± 0.496
2.19IleGln: 2.19 ± 0.411
3.285IleArg: 3.285 ± 0.474
4.067IleSer: 4.067 ± 0.438
3.911IleThr: 3.911 ± 0.482
2.738IleVal: 2.738 ± 0.494
0.548IleTrp: 0.548 ± 0.208
1.799IleTyr: 1.799 ± 0.416
0.0IleXaa: 0.0 ± 0.0
Lys
5.71LysAla: 5.71 ± 0.668
0.548LysCys: 0.548 ± 0.181
3.207LysAsp: 3.207 ± 0.831
3.754LysGlu: 3.754 ± 0.545
1.721LysPhe: 1.721 ± 0.419
3.676LysGly: 3.676 ± 0.581
1.017LysHis: 1.017 ± 0.247
3.05LysIle: 3.05 ± 0.571
3.598LysLys: 3.598 ± 0.565
4.067LysLeu: 4.067 ± 0.597
1.33LysMet: 1.33 ± 0.257
2.581LysAsn: 2.581 ± 0.505
2.19LysPro: 2.19 ± 0.474
1.877LysGln: 1.877 ± 0.368
3.363LysArg: 3.363 ± 0.609
3.442LysSer: 3.442 ± 0.47
5.084LysThr: 5.084 ± 0.619
2.816LysVal: 2.816 ± 0.425
0.469LysTrp: 0.469 ± 0.17
1.799LysTyr: 1.799 ± 0.394
0.0LysXaa: 0.0 ± 0.0
Leu
8.135LeuAla: 8.135 ± 0.769
1.095LeuCys: 1.095 ± 0.299
4.458LeuAsp: 4.458 ± 0.605
6.023LeuGlu: 6.023 ± 0.665
3.363LeuPhe: 3.363 ± 0.54
6.336LeuGly: 6.336 ± 0.962
1.955LeuHis: 1.955 ± 0.479
3.911LeuIle: 3.911 ± 0.626
4.537LeuLys: 4.537 ± 0.572
7.118LeuLeu: 7.118 ± 0.808
2.346LeuMet: 2.346 ± 0.41
3.363LeuAsn: 3.363 ± 0.362
3.05LeuPro: 3.05 ± 0.437
3.911LeuGln: 3.911 ± 0.551
6.336LeuArg: 6.336 ± 0.819
5.944LeuSer: 5.944 ± 0.523
5.319LeuThr: 5.319 ± 0.541
3.598LeuVal: 3.598 ± 0.519
0.782LeuTrp: 0.782 ± 0.24
2.112LeuTyr: 2.112 ± 0.468
0.0LeuXaa: 0.0 ± 0.0
Met
3.598MetAla: 3.598 ± 0.453
0.391MetCys: 0.391 ± 0.188
1.095MetAsp: 1.095 ± 0.315
1.173MetGlu: 1.173 ± 0.356
0.548MetPhe: 0.548 ± 0.183
1.408MetGly: 1.408 ± 0.397
0.313MetHis: 0.313 ± 0.138
0.782MetIle: 0.782 ± 0.21
1.877MetLys: 1.877 ± 0.405
2.346MetLeu: 2.346 ± 0.454
0.86MetMet: 0.86 ± 0.306
1.017MetAsn: 1.017 ± 0.278
1.721MetPro: 1.721 ± 0.389
0.939MetGln: 0.939 ± 0.265
1.564MetArg: 1.564 ± 0.425
1.643MetSer: 1.643 ± 0.345
1.564MetThr: 1.564 ± 0.326
1.33MetVal: 1.33 ± 0.292
0.078MetTrp: 0.078 ± 0.092
0.391MetTyr: 0.391 ± 0.179
0.0MetXaa: 0.0 ± 0.0
Asn
4.537AsnAla: 4.537 ± 0.518
0.235AsnCys: 0.235 ± 0.144
2.894AsnAsp: 2.894 ± 0.409
2.346AsnGlu: 2.346 ± 0.356
1.095AsnPhe: 1.095 ± 0.28
3.911AsnGly: 3.911 ± 0.87
1.251AsnHis: 1.251 ± 0.365
2.346AsnIle: 2.346 ± 0.54
2.19AsnLys: 2.19 ± 0.379
2.19AsnLeu: 2.19 ± 0.434
0.939AsnMet: 0.939 ± 0.286
1.486AsnAsn: 1.486 ± 0.338
2.034AsnPro: 2.034 ± 0.294
2.346AsnGln: 2.346 ± 0.445
2.19AsnArg: 2.19 ± 0.361
2.346AsnSer: 2.346 ± 0.437
1.721AsnThr: 1.721 ± 0.294
2.659AsnVal: 2.659 ± 0.51
0.235AsnTrp: 0.235 ± 0.152
1.173AsnTyr: 1.173 ± 0.407
0.0AsnXaa: 0.0 ± 0.0
Pro
4.302ProAla: 4.302 ± 0.771
0.782ProCys: 0.782 ± 0.297
2.659ProAsp: 2.659 ± 0.722
4.771ProGlu: 4.771 ± 1.05
1.251ProPhe: 1.251 ± 0.315
2.972ProGly: 2.972 ± 0.423
0.626ProHis: 0.626 ± 0.247
1.33ProIle: 1.33 ± 0.33
2.659ProLys: 2.659 ± 0.408
3.285ProLeu: 3.285 ± 0.632
1.095ProMet: 1.095 ± 0.227
1.486ProAsn: 1.486 ± 0.373
1.799ProPro: 1.799 ± 0.317
2.112ProGln: 2.112 ± 0.427
1.955ProArg: 1.955 ± 0.339
1.721ProSer: 1.721 ± 0.428
2.034ProThr: 2.034 ± 0.452
3.05ProVal: 3.05 ± 0.526
0.313ProTrp: 0.313 ± 0.143
0.86ProTyr: 0.86 ± 0.257
0.0ProXaa: 0.0 ± 0.0
Gln
6.961GlnAla: 6.961 ± 1.068
0.313GlnCys: 0.313 ± 0.185
2.268GlnAsp: 2.268 ± 0.419
3.52GlnGlu: 3.52 ± 0.582
2.19GlnPhe: 2.19 ± 0.451
2.738GlnGly: 2.738 ± 0.392
0.782GlnHis: 0.782 ± 0.241
3.207GlnIle: 3.207 ± 0.559
2.894GlnLys: 2.894 ± 0.472
3.833GlnLeu: 3.833 ± 0.566
0.86GlnMet: 0.86 ± 0.211
1.643GlnAsn: 1.643 ± 0.46
1.408GlnPro: 1.408 ± 0.334
4.302GlnGln: 4.302 ± 0.972
3.442GlnArg: 3.442 ± 0.519
2.659GlnSer: 2.659 ± 0.31
2.268GlnThr: 2.268 ± 0.439
2.346GlnVal: 2.346 ± 0.431
0.86GlnTrp: 0.86 ± 0.181
1.251GlnTyr: 1.251 ± 0.368
0.0GlnXaa: 0.0 ± 0.0
Arg
6.257ArgAla: 6.257 ± 0.804
0.626ArgCys: 0.626 ± 0.258
3.598ArgAsp: 3.598 ± 0.652
4.067ArgGlu: 4.067 ± 0.523
3.52ArgPhe: 3.52 ± 0.401
3.285ArgGly: 3.285 ± 0.65
0.782ArgHis: 0.782 ± 0.279
3.207ArgIle: 3.207 ± 0.562
3.989ArgLys: 3.989 ± 0.738
6.023ArgLeu: 6.023 ± 0.791
1.564ArgMet: 1.564 ± 0.288
2.346ArgAsn: 2.346 ± 0.428
2.738ArgPro: 2.738 ± 0.578
5.084ArgGln: 5.084 ± 0.768
5.006ArgArg: 5.006 ± 0.637
2.581ArgSer: 2.581 ± 0.413
2.972ArgThr: 2.972 ± 0.491
3.989ArgVal: 3.989 ± 0.601
0.86ArgTrp: 0.86 ± 0.21
2.503ArgTyr: 2.503 ± 0.44
0.0ArgXaa: 0.0 ± 0.0
Ser
5.632SerAla: 5.632 ± 0.637
0.391SerCys: 0.391 ± 0.171
2.425SerAsp: 2.425 ± 0.42
4.771SerGlu: 4.771 ± 0.951
1.799SerPhe: 1.799 ± 0.35
4.849SerGly: 4.849 ± 0.628
1.877SerHis: 1.877 ± 0.351
3.129SerIle: 3.129 ± 0.511
2.816SerLys: 2.816 ± 0.595
5.319SerLeu: 5.319 ± 0.724
1.095SerMet: 1.095 ± 0.268
1.955SerAsn: 1.955 ± 0.649
2.268SerPro: 2.268 ± 0.327
2.346SerGln: 2.346 ± 0.396
3.598SerArg: 3.598 ± 0.521
3.52SerSer: 3.52 ± 0.534
2.19SerThr: 2.19 ± 0.393
3.989SerVal: 3.989 ± 0.542
0.86SerTrp: 0.86 ± 0.217
1.251SerTyr: 1.251 ± 0.275
0.0SerXaa: 0.0 ± 0.0
Thr
5.475ThrAla: 5.475 ± 0.702
0.626ThrCys: 0.626 ± 0.198
3.598ThrAsp: 3.598 ± 0.471
3.442ThrGlu: 3.442 ± 0.497
1.955ThrPhe: 1.955 ± 0.46
5.553ThrGly: 5.553 ± 0.69
1.486ThrHis: 1.486 ± 0.438
2.268ThrIle: 2.268 ± 0.341
2.034ThrLys: 2.034 ± 0.415
5.632ThrLeu: 5.632 ± 0.649
0.391ThrMet: 0.391 ± 0.146
1.564ThrAsn: 1.564 ± 0.331
3.363ThrPro: 3.363 ± 0.452
2.738ThrGln: 2.738 ± 0.442
2.816ThrArg: 2.816 ± 0.485
2.659ThrSer: 2.659 ± 0.49
2.503ThrThr: 2.503 ± 0.529
5.084ThrVal: 5.084 ± 0.933
0.391ThrTrp: 0.391 ± 0.154
1.877ThrTyr: 1.877 ± 0.29
0.0ThrXaa: 0.0 ± 0.0
Val
6.414ValAla: 6.414 ± 0.774
1.017ValCys: 1.017 ± 0.244
4.224ValAsp: 4.224 ± 0.639
3.989ValGlu: 3.989 ± 0.763
1.877ValPhe: 1.877 ± 0.424
3.598ValGly: 3.598 ± 0.548
1.017ValHis: 1.017 ± 0.235
3.833ValIle: 3.833 ± 0.529
4.302ValLys: 4.302 ± 0.499
4.928ValLeu: 4.928 ± 0.646
1.564ValMet: 1.564 ± 0.296
2.581ValAsn: 2.581 ± 0.385
2.816ValPro: 2.816 ± 0.427
1.799ValGln: 1.799 ± 0.494
4.458ValArg: 4.458 ± 0.606
4.145ValSer: 4.145 ± 0.648
3.911ValThr: 3.911 ± 0.53
3.05ValVal: 3.05 ± 0.638
0.782ValTrp: 0.782 ± 0.193
2.034ValTyr: 2.034 ± 0.45
0.0ValXaa: 0.0 ± 0.0
Trp
1.173TrpAla: 1.173 ± 0.265
0.235TrpCys: 0.235 ± 0.11
0.782TrpAsp: 0.782 ± 0.314
1.017TrpGlu: 1.017 ± 0.245
0.548TrpPhe: 0.548 ± 0.224
0.939TrpGly: 0.939 ± 0.287
0.391TrpHis: 0.391 ± 0.176
0.078TrpIle: 0.078 ± 0.072
0.391TrpLys: 0.391 ± 0.192
1.251TrpLeu: 1.251 ± 0.325
0.469TrpMet: 0.469 ± 0.166
0.313TrpAsn: 0.313 ± 0.14
0.626TrpPro: 0.626 ± 0.227
0.626TrpGln: 0.626 ± 0.211
1.251TrpArg: 1.251 ± 0.343
0.626TrpSer: 0.626 ± 0.174
0.704TrpThr: 0.704 ± 0.22
0.704TrpVal: 0.704 ± 0.246
0.156TrpTrp: 0.156 ± 0.141
0.235TrpTyr: 0.235 ± 0.142
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.19TyrAla: 2.19 ± 0.496
0.626TyrCys: 0.626 ± 0.204
2.503TyrAsp: 2.503 ± 0.616
1.564TyrGlu: 1.564 ± 0.32
1.095TyrPhe: 1.095 ± 0.38
1.408TyrGly: 1.408 ± 0.311
0.548TyrHis: 0.548 ± 0.179
1.33TyrIle: 1.33 ± 0.294
0.548TyrLys: 0.548 ± 0.134
3.05TyrLeu: 3.05 ± 0.532
0.469TyrMet: 0.469 ± 0.176
1.33TyrAsn: 1.33 ± 0.429
1.486TyrPro: 1.486 ± 0.305
1.721TyrGln: 1.721 ± 0.37
2.503TyrArg: 2.503 ± 0.486
2.112TyrSer: 2.112 ± 0.444
1.486TyrThr: 1.486 ± 0.349
1.799TyrVal: 1.799 ± 0.301
0.235TyrTrp: 0.235 ± 0.122
1.173TyrTyr: 1.173 ± 0.272
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 51 proteins (12786 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski