Amino acid dipepetide frequency for Aerococcus urinaehominis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.543AlaAla: 7.543 ± 0.169
0.724AlaCys: 0.724 ± 0.037
6.958AlaAsp: 6.958 ± 0.132
5.057AlaGlu: 5.057 ± 0.126
3.278AlaPhe: 3.278 ± 0.084
7.337AlaGly: 7.337 ± 0.16
1.603AlaHis: 1.603 ± 0.059
6.294AlaIle: 6.294 ± 0.128
5.008AlaLys: 5.008 ± 0.106
8.528AlaLeu: 8.528 ± 0.176
2.306AlaMet: 2.306 ± 0.072
4.155AlaAsn: 4.155 ± 0.102
2.255AlaPro: 2.255 ± 0.072
4.393AlaGln: 4.393 ± 0.11
3.235AlaArg: 3.235 ± 0.086
5.988AlaSer: 5.988 ± 0.133
4.079AlaThr: 4.079 ± 0.085
5.508AlaVal: 5.508 ± 0.114
0.891AlaTrp: 0.891 ± 0.042
3.669AlaTyr: 3.669 ± 0.1
0.0AlaXaa: 0.0 ± 0.0
Cys
0.366CysAla: 0.366 ± 0.029
0.058CysCys: 0.058 ± 0.011
0.35CysAsp: 0.35 ± 0.026
0.209CysGlu: 0.209 ± 0.021
0.292CysPhe: 0.292 ± 0.026
0.523CysGly: 0.523 ± 0.034
0.184CysHis: 0.184 ± 0.021
0.302CysIle: 0.302 ± 0.024
0.166CysLys: 0.166 ± 0.017
0.836CysLeu: 0.836 ± 0.052
0.083CysMet: 0.083 ± 0.013
0.172CysAsn: 0.172 ± 0.017
0.337CysPro: 0.337 ± 0.028
0.623CysGln: 0.623 ± 0.04
0.277CysArg: 0.277 ± 0.022
0.3CysSer: 0.3 ± 0.024
0.213CysThr: 0.213 ± 0.02
0.3CysVal: 0.3 ± 0.024
0.048CysTrp: 0.048 ± 0.009
0.3CysTyr: 0.3 ± 0.027
0.0CysXaa: 0.0 ± 0.0
Asp
3.764AspAla: 3.764 ± 0.103
0.399AspCys: 0.399 ± 0.029
3.516AspAsp: 3.516 ± 0.127
3.874AspGlu: 3.874 ± 0.089
3.16AspPhe: 3.16 ± 0.075
4.255AspGly: 4.255 ± 0.39
1.808AspHis: 1.808 ± 0.078
4.53AspIle: 4.53 ± 0.095
3.647AspLys: 3.647 ± 0.122
7.641AspLeu: 7.641 ± 0.162
1.94AspMet: 1.94 ± 0.064
2.616AspAsn: 2.616 ± 0.117
2.263AspPro: 2.263 ± 0.087
7.208AspGln: 7.208 ± 0.175
3.225AspArg: 3.225 ± 0.079
3.049AspSer: 3.049 ± 0.076
2.488AspThr: 2.488 ± 0.082
3.34AspVal: 3.34 ± 0.082
0.741AspTrp: 0.741 ± 0.04
3.403AspTyr: 3.403 ± 0.1
0.0AspXaa: 0.0 ± 0.0
Glu
6.05GluAla: 6.05 ± 0.136
0.197GluCys: 0.197 ± 0.022
3.853GluAsp: 3.853 ± 0.108
4.47GluGlu: 4.47 ± 0.11
2.064GluPhe: 2.064 ± 0.066
3.481GluGly: 3.481 ± 0.09
0.815GluHis: 0.815 ± 0.044
5.008GluIle: 5.008 ± 0.122
3.826GluLys: 3.826 ± 0.102
5.549GluLeu: 5.549 ± 0.116
1.787GluMet: 1.787 ± 0.055
3.051GluAsn: 3.051 ± 0.084
1.816GluPro: 1.816 ± 0.096
2.068GluGln: 2.068 ± 0.065
2.592GluArg: 2.592 ± 0.081
2.827GluSer: 2.827 ± 0.081
3.065GluThr: 3.065 ± 0.131
4.358GluVal: 4.358 ± 0.157
0.503GluTrp: 0.503 ± 0.033
1.603GluTyr: 1.603 ± 0.064
0.0GluXaa: 0.0 ± 0.0
Phe
3.278PheAla: 3.278 ± 0.091
0.323PheCys: 0.323 ± 0.026
2.77PheAsp: 2.77 ± 0.076
2.118PheGlu: 2.118 ± 0.067
1.686PhePhe: 1.686 ± 0.063
2.83PheGly: 2.83 ± 0.094
0.668PheHis: 0.668 ± 0.035
3.063PheIle: 3.063 ± 0.097
2.232PheLys: 2.232 ± 0.077
3.543PheLeu: 3.543 ± 0.111
1.136PheMet: 1.136 ± 0.052
1.977PheAsn: 1.977 ± 0.064
1.473PhePro: 1.473 ± 0.057
1.481PheGln: 1.481 ± 0.059
1.34PheArg: 1.34 ± 0.053
2.699PheSer: 2.699 ± 0.077
2.232PheThr: 2.232 ± 0.07
2.561PheVal: 2.561 ± 0.066
0.333PheTrp: 0.333 ± 0.023
1.622PheTyr: 1.622 ± 0.059
0.0PheXaa: 0.0 ± 0.0
Gly
4.877GlyAla: 4.877 ± 0.105
0.418GlyCys: 0.418 ± 0.03
4.104GlyAsp: 4.104 ± 0.146
4.002GlyGlu: 4.002 ± 0.226
2.828GlyPhe: 2.828 ± 0.086
4.43GlyGly: 4.43 ± 0.104
1.642GlyHis: 1.642 ± 0.053
4.701GlyIle: 4.701 ± 0.111
3.911GlyLys: 3.911 ± 0.236
7.61GlyLeu: 7.61 ± 0.142
1.814GlyMet: 1.814 ± 0.061
2.457GlyAsn: 2.457 ± 0.084
2.091GlyPro: 2.091 ± 0.087
5.322GlyGln: 5.322 ± 0.122
3.311GlyArg: 3.311 ± 0.089
3.719GlySer: 3.719 ± 0.093
3.392GlyThr: 3.392 ± 0.183
4.544GlyVal: 4.544 ± 0.105
0.6GlyTrp: 0.6 ± 0.032
2.819GlyTyr: 2.819 ± 0.076
0.0GlyXaa: 0.0 ± 0.0
His
1.268HisAla: 1.268 ± 0.053
0.157HisCys: 0.157 ± 0.02
1.216HisAsp: 1.216 ± 0.057
1.086HisGlu: 1.086 ± 0.049
1.148HisPhe: 1.148 ± 0.05
1.351HisGly: 1.351 ± 0.063
0.635HisHis: 0.635 ± 0.042
1.404HisIle: 1.404 ± 0.057
0.821HisLys: 0.821 ± 0.044
2.07HisLeu: 2.07 ± 0.062
0.449HisMet: 0.449 ± 0.031
0.782HisAsn: 0.782 ± 0.04
1.08HisPro: 1.08 ± 0.045
1.394HisGln: 1.394 ± 0.061
0.891HisArg: 0.891 ± 0.045
0.954HisSer: 0.954 ± 0.039
0.958HisThr: 0.958 ± 0.087
1.136HisVal: 1.136 ± 0.047
0.199HisTrp: 0.199 ± 0.021
1.016HisTyr: 1.016 ± 0.051
0.0HisXaa: 0.0 ± 0.0
Ile
6.143IleAla: 6.143 ± 0.134
0.554IleCys: 0.554 ± 0.036
4.908IleAsp: 4.908 ± 0.1
4.1IleGlu: 4.1 ± 0.113
3.107IlePhe: 3.107 ± 0.1
4.793IleGly: 4.793 ± 0.106
1.22IleHis: 1.22 ± 0.064
5.068IleIle: 5.068 ± 0.115
4.149IleLys: 4.149 ± 0.092
6.441IleLeu: 6.441 ± 0.132
1.607IleMet: 1.607 ± 0.056
3.402IleAsn: 3.402 ± 0.09
2.621IlePro: 2.621 ± 0.069
2.883IleGln: 2.883 ± 0.091
2.695IleArg: 2.695 ± 0.079
4.424IleSer: 4.424 ± 0.105
3.638IleThr: 3.638 ± 0.11
4.559IleVal: 4.559 ± 0.1
0.534IleTrp: 0.534 ± 0.036
2.741IleTyr: 2.741 ± 0.089
0.0IleXaa: 0.0 ± 0.0
Lys
4.573LysAla: 4.573 ± 0.115
0.165LysCys: 0.165 ± 0.018
3.738LysAsp: 3.738 ± 0.259
3.785LysGlu: 3.785 ± 0.105
1.607LysPhe: 1.607 ± 0.059
3.161LysGly: 3.161 ± 0.125
0.985LysHis: 0.985 ± 0.043
3.587LysIle: 3.587 ± 0.089
3.13LysLys: 3.13 ± 0.103
4.768LysLeu: 4.768 ± 0.121
1.402LysMet: 1.402 ± 0.052
2.393LysAsn: 2.393 ± 0.08
1.975LysPro: 1.975 ± 0.084
3.026LysGln: 3.026 ± 0.08
2.492LysArg: 2.492 ± 0.076
2.732LysSer: 2.732 ± 0.084
2.927LysThr: 2.927 ± 0.087
3.607LysVal: 3.607 ± 0.142
0.42LysTrp: 0.42 ± 0.027
1.862LysTyr: 1.862 ± 0.063
0.0LysXaa: 0.0 ± 0.0
Leu
12.388LeuAla: 12.388 ± 0.239
0.515LeuCys: 0.515 ± 0.035
6.842LeuAsp: 6.842 ± 0.155
5.581LeuGlu: 5.581 ± 0.124
3.489LeuPhe: 3.489 ± 0.095
6.679LeuGly: 6.679 ± 0.127
1.38LeuHis: 1.38 ± 0.05
6.803LeuIle: 6.803 ± 0.178
5.028LeuLys: 5.028 ± 0.114
9.235LeuLeu: 9.235 ± 0.227
2.449LeuMet: 2.449 ± 0.081
4.464LeuAsn: 4.464 ± 0.109
3.868LeuPro: 3.868 ± 0.091
3.405LeuGln: 3.405 ± 0.091
3.384LeuArg: 3.384 ± 0.095
6.518LeuSer: 6.518 ± 0.139
6.079LeuThr: 6.079 ± 0.13
8.06LeuVal: 8.06 ± 0.163
0.647LeuTrp: 0.647 ± 0.033
3.049LeuTyr: 3.049 ± 0.084
0.0LeuXaa: 0.0 ± 0.0
Met
2.782MetAla: 2.782 ± 0.071
0.087MetCys: 0.087 ± 0.012
1.375MetAsp: 1.375 ± 0.053
1.088MetGlu: 1.088 ± 0.044
0.734MetPhe: 0.734 ± 0.045
1.744MetGly: 1.744 ± 0.062
0.356MetHis: 0.356 ± 0.026
1.725MetIle: 1.725 ± 0.061
1.411MetLys: 1.411 ± 0.05
2.325MetLeu: 2.325 ± 0.071
0.703MetMet: 0.703 ± 0.042
1.08MetAsn: 1.08 ± 0.048
1.045MetPro: 1.045 ± 0.042
1.024MetGln: 1.024 ± 0.047
1.133MetArg: 1.133 ± 0.045
1.663MetSer: 1.663 ± 0.057
1.919MetThr: 1.919 ± 0.065
1.971MetVal: 1.971 ± 0.06
0.139MetTrp: 0.139 ± 0.017
0.641MetTyr: 0.641 ± 0.033
0.0MetXaa: 0.0 ± 0.0
Asn
2.629AsnAla: 2.629 ± 0.082
0.321AsnCys: 0.321 ± 0.023
2.441AsnAsp: 2.441 ± 0.065
2.387AsnGlu: 2.387 ± 0.084
1.915AsnPhe: 1.915 ± 0.067
2.823AsnGly: 2.823 ± 0.155
1.249AsnHis: 1.249 ± 0.054
3.07AsnIle: 3.07 ± 0.076
2.221AsnLys: 2.221 ± 0.072
4.385AsnLeu: 4.385 ± 0.091
1.119AsnMet: 1.119 ± 0.044
2.011AsnAsn: 2.011 ± 0.06
2.35AsnPro: 2.35 ± 0.107
3.822AsnGln: 3.822 ± 0.107
2.263AsnArg: 2.263 ± 0.068
1.99AsnSer: 1.99 ± 0.073
1.771AsnThr: 1.771 ± 0.054
2.333AsnVal: 2.333 ± 0.067
0.523AsnTrp: 0.523 ± 0.03
2.11AsnTyr: 2.11 ± 0.07
0.0AsnXaa: 0.0 ± 0.0
Pro
3.481ProAla: 3.481 ± 0.097
0.196ProCys: 0.196 ± 0.018
2.956ProAsp: 2.956 ± 0.093
2.695ProGlu: 2.695 ± 0.1
1.388ProPhe: 1.388 ± 0.049
3.022ProGly: 3.022 ± 0.151
0.74ProHis: 0.74 ± 0.038
2.374ProIle: 2.374 ± 0.075
1.667ProLys: 1.667 ± 0.066
3.264ProLeu: 3.264 ± 0.081
0.724ProMet: 0.724 ± 0.038
1.839ProAsn: 1.839 ± 0.064
0.649ProPro: 0.649 ± 0.038
1.715ProGln: 1.715 ± 0.136
1.133ProArg: 1.133 ± 0.052
2.304ProSer: 2.304 ± 0.074
1.988ProThr: 1.988 ± 0.095
3.032ProVal: 3.032 ± 0.15
0.294ProTrp: 0.294 ± 0.027
1.481ProTyr: 1.481 ± 0.06
0.0ProXaa: 0.0 ± 0.0
Gln
8.706GlnAla: 8.706 ± 0.161
0.221GlnCys: 0.221 ± 0.022
3.953GlnAsp: 3.953 ± 0.101
3.744GlnGlu: 3.744 ± 0.085
1.682GlnPhe: 1.682 ± 0.058
3.543GlnGly: 3.543 ± 0.094
0.848GlnHis: 0.848 ± 0.047
3.638GlnIle: 3.638 ± 0.088
2.17GlnLys: 2.17 ± 0.066
6.013GlnLeu: 6.013 ± 0.156
1.264GlnMet: 1.264 ± 0.054
1.924GlnAsn: 1.924 ± 0.061
2.184GlnPro: 2.184 ± 0.088
2.306GlnGln: 2.306 ± 0.088
2.132GlnArg: 2.132 ± 0.079
2.842GlnSer: 2.842 ± 0.079
2.939GlnThr: 2.939 ± 0.089
5.411GlnVal: 5.411 ± 0.126
0.439GlnTrp: 0.439 ± 0.026
1.51GlnTyr: 1.51 ± 0.055
0.0GlnXaa: 0.0 ± 0.0
Arg
2.956ArgAla: 2.956 ± 0.082
0.176ArgCys: 0.176 ± 0.018
2.805ArgAsp: 2.805 ± 0.105
2.554ArgGlu: 2.554 ± 0.077
1.82ArgPhe: 1.82 ± 0.056
2.401ArgGly: 2.401 ± 0.076
0.983ArgHis: 0.983 ± 0.048
2.815ArgIle: 2.815 ± 0.087
2.052ArgLys: 2.052 ± 0.069
4.793ArgLeu: 4.793 ± 0.117
1.049ArgMet: 1.049 ± 0.048
1.593ArgAsn: 1.593 ± 0.064
1.737ArgPro: 1.737 ± 0.062
3.134ArgGln: 3.134 ± 0.089
2.315ArgArg: 2.315 ± 0.081
2.062ArgSer: 2.062 ± 0.065
1.917ArgThr: 1.917 ± 0.07
2.765ArgVal: 2.765 ± 0.084
0.267ArgTrp: 0.267 ± 0.021
1.845ArgTyr: 1.845 ± 0.066
0.0ArgXaa: 0.0 ± 0.0
Ser
3.835SerAla: 3.835 ± 0.095
0.314SerCys: 0.314 ± 0.028
3.446SerAsp: 3.446 ± 0.091
2.908SerGlu: 2.908 ± 0.076
2.627SerPhe: 2.627 ± 0.083
4.091SerGly: 4.091 ± 0.102
1.504SerHis: 1.504 ± 0.049
3.264SerIle: 3.264 ± 0.088
2.848SerLys: 2.848 ± 0.082
6.722SerLeu: 6.722 ± 0.15
1.266SerMet: 1.266 ± 0.045
2.325SerAsn: 2.325 ± 0.066
2.238SerPro: 2.238 ± 0.08
5.059SerGln: 5.059 ± 0.142
2.722SerArg: 2.722 ± 0.067
3.281SerSer: 3.281 ± 0.095
2.348SerThr: 2.348 ± 0.074
3.489SerVal: 3.489 ± 0.085
0.538SerTrp: 0.538 ± 0.029
2.422SerTyr: 2.422 ± 0.075
0.0SerXaa: 0.0 ± 0.0
Thr
4.269ThrAla: 4.269 ± 0.098
0.337ThrCys: 0.337 ± 0.028
3.518ThrAsp: 3.518 ± 0.109
2.774ThrGlu: 2.774 ± 0.12
1.748ThrPhe: 1.748 ± 0.062
4.342ThrGly: 4.342 ± 0.127
1.055ThrHis: 1.055 ± 0.096
4.246ThrIle: 4.246 ± 0.13
2.639ThrLys: 2.639 ± 0.103
4.232ThrLeu: 4.232 ± 0.097
1.208ThrMet: 1.208 ± 0.053
2.432ThrAsn: 2.432 ± 0.091
2.435ThrPro: 2.435 ± 0.145
1.727ThrGln: 1.727 ± 0.06
1.797ThrArg: 1.797 ± 0.067
3.442ThrSer: 3.442 ± 0.093
2.776ThrThr: 2.776 ± 0.158
3.913ThrVal: 3.913 ± 0.206
0.529ThrTrp: 0.529 ± 0.035
1.891ThrTyr: 1.891 ± 0.065
0.0ThrXaa: 0.0 ± 0.0
Val
6.561ValAla: 6.561 ± 0.129
0.461ValCys: 0.461 ± 0.03
5.037ValAsp: 5.037 ± 0.122
4.071ValGlu: 4.071 ± 0.118
2.581ValPhe: 2.581 ± 0.074
4.673ValGly: 4.673 ± 0.098
1.14ValHis: 1.14 ± 0.048
4.904ValIle: 4.904 ± 0.106
3.798ValLys: 3.798 ± 0.119
5.973ValLeu: 5.973 ± 0.133
1.63ValMet: 1.63 ± 0.056
3.33ValAsn: 3.33 ± 0.087
2.515ValPro: 2.515 ± 0.102
2.484ValGln: 2.484 ± 0.072
2.637ValArg: 2.637 ± 0.114
4.284ValSer: 4.284 ± 0.095
4.397ValThr: 4.397 ± 0.184
5.363ValVal: 5.363 ± 0.128
0.527ValTrp: 0.527 ± 0.036
2.424ValTyr: 2.424 ± 0.074
0.0ValXaa: 0.0 ± 0.0
Trp
0.687TrpAla: 0.687 ± 0.035
0.033TrpCys: 0.033 ± 0.008
0.445TrpAsp: 0.445 ± 0.03
0.412TrpGlu: 0.412 ± 0.026
0.314TrpPhe: 0.314 ± 0.029
0.532TrpGly: 0.532 ± 0.035
0.199TrpHis: 0.199 ± 0.017
0.484TrpIle: 0.484 ± 0.03
0.271TrpLys: 0.271 ± 0.023
1.365TrpLeu: 1.365 ± 0.061
0.161TrpMet: 0.161 ± 0.021
0.252TrpAsn: 0.252 ± 0.023
0.389TrpPro: 0.389 ± 0.029
0.894TrpGln: 0.894 ± 0.041
0.451TrpArg: 0.451 ± 0.031
0.461TrpSer: 0.461 ± 0.025
0.465TrpThr: 0.465 ± 0.027
0.459TrpVal: 0.459 ± 0.026
0.105TrpTrp: 0.105 ± 0.017
0.296TrpTyr: 0.296 ± 0.026
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.652TyrAla: 2.652 ± 0.082
0.287TyrCys: 0.287 ± 0.023
2.635TyrAsp: 2.635 ± 0.071
2.066TyrGlu: 2.066 ± 0.06
1.899TyrPhe: 1.899 ± 0.061
2.577TyrGly: 2.577 ± 0.067
1.001TyrHis: 1.001 ± 0.043
2.308TyrIle: 2.308 ± 0.07
1.34TyrLys: 1.34 ± 0.054
4.571TyrLeu: 4.571 ± 0.12
0.846TyrMet: 0.846 ± 0.045
1.479TyrAsn: 1.479 ± 0.05
1.618TyrPro: 1.618 ± 0.054
3.502TyrGln: 3.502 ± 0.112
2.017TyrArg: 2.017 ± 0.069
1.709TyrSer: 1.709 ± 0.064
1.719TyrThr: 1.719 ± 0.061
2.083TyrVal: 2.083 ± 0.065
0.397TyrTrp: 0.397 ± 0.028
1.787TyrTyr: 1.787 ± 0.07
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1595 proteins (516534 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski