Amino acid dipepetide frequency for Paenibacillus montanisoli

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
10.705AlaAla: 10.705 ± 0.138
0.836AlaCys: 0.836 ± 0.025
4.846AlaAsp: 4.846 ± 0.059
6.184AlaGlu: 6.184 ± 0.078
3.676AlaPhe: 3.676 ± 0.049
7.4AlaGly: 7.4 ± 0.08
1.612AlaHis: 1.612 ± 0.027
5.693AlaIle: 5.693 ± 0.062
4.561AlaLys: 4.561 ± 0.057
8.721AlaLeu: 8.721 ± 0.093
2.494AlaMet: 2.494 ± 0.037
2.887AlaAsn: 2.887 ± 0.046
3.01AlaPro: 3.01 ± 0.051
2.758AlaGln: 2.758 ± 0.045
3.893AlaArg: 3.893 ± 0.053
5.533AlaSer: 5.533 ± 0.058
3.58AlaThr: 3.58 ± 0.055
6.954AlaVal: 6.954 ± 0.082
1.121AlaTrp: 1.121 ± 0.026
2.875AlaTyr: 2.875 ± 0.038
0.0AlaXaa: 0.0 ± 0.0
Cys
0.655CysAla: 0.655 ± 0.019
0.133CysCys: 0.133 ± 0.009
0.452CysAsp: 0.452 ± 0.017
0.495CysGlu: 0.495 ± 0.017
0.338CysPhe: 0.338 ± 0.015
0.88CysGly: 0.88 ± 0.023
0.205CysHis: 0.205 ± 0.011
0.495CysIle: 0.495 ± 0.017
0.356CysLys: 0.356 ± 0.013
0.808CysLeu: 0.808 ± 0.023
0.239CysMet: 0.239 ± 0.011
0.284CysAsn: 0.284 ± 0.013
0.404CysPro: 0.404 ± 0.017
0.223CysGln: 0.223 ± 0.011
0.498CysArg: 0.498 ± 0.018
0.608CysSer: 0.608 ± 0.02
0.447CysThr: 0.447 ± 0.016
0.494CysVal: 0.494 ± 0.018
0.125CysTrp: 0.125 ± 0.008
0.313CysTyr: 0.313 ± 0.013
0.0CysXaa: 0.0 ± 0.0
Asp
4.606AspAla: 4.606 ± 0.046
0.445AspCys: 0.445 ± 0.015
2.471AspAsp: 2.471 ± 0.046
3.848AspGlu: 3.848 ± 0.041
2.146AspPhe: 2.146 ± 0.036
4.347AspGly: 4.347 ± 0.057
1.071AspHis: 1.071 ± 0.027
3.386AspIle: 3.386 ± 0.046
2.543AspLys: 2.543 ± 0.044
4.656AspLeu: 4.656 ± 0.051
1.418AspMet: 1.418 ± 0.03
1.8AspAsn: 1.8 ± 0.034
2.526AspPro: 2.526 ± 0.042
1.795AspGln: 1.795 ± 0.033
3.02AspArg: 3.02 ± 0.043
2.63AspSer: 2.63 ± 0.044
2.441AspThr: 2.441 ± 0.038
3.601AspVal: 3.601 ± 0.043
0.925AspTrp: 0.925 ± 0.026
2.144AspTyr: 2.144 ± 0.03
0.0AspXaa: 0.0 ± 0.0
Glu
6.586GluAla: 6.586 ± 0.088
0.4GluCys: 0.4 ± 0.017
2.886GluAsp: 2.886 ± 0.043
4.935GluGlu: 4.935 ± 0.063
2.093GluPhe: 2.093 ± 0.035
4.422GluGly: 4.422 ± 0.056
1.581GluHis: 1.581 ± 0.028
3.95GluIle: 3.95 ± 0.044
3.573GluLys: 3.573 ± 0.058
7.342GluLeu: 7.342 ± 0.081
1.9GluMet: 1.9 ± 0.031
2.256GluAsn: 2.256 ± 0.032
2.506GluPro: 2.506 ± 0.036
3.446GluGln: 3.446 ± 0.048
4.434GluArg: 4.434 ± 0.07
3.451GluSer: 3.451 ± 0.042
3.357GluThr: 3.357 ± 0.045
4.084GluVal: 4.084 ± 0.051
1.039GluTrp: 1.039 ± 0.027
1.797GluTyr: 1.797 ± 0.037
0.0GluXaa: 0.0 ± 0.0
Phe
3.536PheAla: 3.536 ± 0.047
0.354PheCys: 0.354 ± 0.014
2.407PheAsp: 2.407 ± 0.041
2.417PheGlu: 2.417 ± 0.036
1.88PhePhe: 1.88 ± 0.032
3.399PheGly: 3.399 ± 0.047
0.984PheHis: 0.984 ± 0.023
2.915PheIle: 2.915 ± 0.042
1.954PheLys: 1.954 ± 0.03
3.678PheLeu: 3.678 ± 0.053
1.24PheMet: 1.24 ± 0.03
1.595PheAsn: 1.595 ± 0.027
1.661PhePro: 1.661 ± 0.032
1.354PheGln: 1.354 ± 0.024
2.176PheArg: 2.176 ± 0.038
2.743PheSer: 2.743 ± 0.041
2.456PheThr: 2.456 ± 0.036
2.975PheVal: 2.975 ± 0.048
0.564PheTrp: 0.564 ± 0.017
1.495PheTyr: 1.495 ± 0.031
0.0PheXaa: 0.0 ± 0.0
Gly
6.138GlyAla: 6.138 ± 0.09
0.833GlyCys: 0.833 ± 0.023
3.72GlyAsp: 3.72 ± 0.045
4.635GlyGlu: 4.635 ± 0.055
3.386GlyPhe: 3.386 ± 0.041
6.064GlyGly: 6.064 ± 0.087
1.638GlyHis: 1.638 ± 0.031
5.636GlyIle: 5.636 ± 0.061
4.501GlyLys: 4.501 ± 0.058
7.291GlyLeu: 7.291 ± 0.076
2.458GlyMet: 2.458 ± 0.036
2.699GlyAsn: 2.699 ± 0.045
2.131GlyPro: 2.131 ± 0.037
2.669GlyGln: 2.669 ± 0.044
3.734GlyArg: 3.734 ± 0.052
4.985GlySer: 4.985 ± 0.068
4.514GlyThr: 4.514 ± 0.064
5.219GlyVal: 5.219 ± 0.054
1.197GlyTrp: 1.197 ± 0.029
3.0GlyTyr: 3.0 ± 0.045
0.0GlyXaa: 0.0 ± 0.0
His
1.869HisAla: 1.869 ± 0.035
0.227HisCys: 0.227 ± 0.012
1.123HisAsp: 1.123 ± 0.029
1.386HisGlu: 1.386 ± 0.028
1.05HisPhe: 1.05 ± 0.024
1.699HisGly: 1.699 ± 0.032
0.655HisHis: 0.655 ± 0.024
1.364HisIle: 1.364 ± 0.028
0.798HisLys: 0.798 ± 0.021
2.086HisLeu: 2.086 ± 0.037
0.585HisMet: 0.585 ± 0.019
0.729HisAsn: 0.729 ± 0.019
1.287HisPro: 1.287 ± 0.026
0.732HisGln: 0.732 ± 0.021
1.202HisArg: 1.202 ± 0.028
1.193HisSer: 1.193 ± 0.025
1.027HisThr: 1.027 ± 0.024
1.487HisVal: 1.487 ± 0.027
0.357HisTrp: 0.357 ± 0.015
0.938HisTyr: 0.938 ± 0.022
0.0HisXaa: 0.0 ± 0.0
Ile
6.218IleAla: 6.218 ± 0.062
0.665IleCys: 0.665 ± 0.021
3.91IleAsp: 3.91 ± 0.044
4.347IleGlu: 4.347 ± 0.065
2.243IlePhe: 2.243 ± 0.036
5.614IleGly: 5.614 ± 0.06
1.467IleHis: 1.467 ± 0.029
3.948IleIle: 3.948 ± 0.062
2.824IleLys: 2.824 ± 0.048
5.222IleLeu: 5.222 ± 0.066
1.636IleMet: 1.636 ± 0.025
2.225IleAsn: 2.225 ± 0.038
3.118IlePro: 3.118 ± 0.048
2.18IleGln: 2.18 ± 0.034
3.826IleArg: 3.826 ± 0.053
4.054IleSer: 4.054 ± 0.049
3.555IleThr: 3.555 ± 0.05
5.219IleVal: 5.219 ± 0.057
0.762IleTrp: 0.762 ± 0.02
2.067IleTyr: 2.067 ± 0.034
0.0IleXaa: 0.0 ± 0.0
Lys
4.406LysAla: 4.406 ± 0.054
0.258LysCys: 0.258 ± 0.01
2.681LysAsp: 2.681 ± 0.046
3.856LysGlu: 3.856 ± 0.06
1.544LysPhe: 1.544 ± 0.034
3.42LysGly: 3.42 ± 0.048
1.16LysHis: 1.16 ± 0.024
2.668LysIle: 2.668 ± 0.047
2.841LysLys: 2.841 ± 0.055
5.67LysLeu: 5.67 ± 0.071
1.453LysMet: 1.453 ± 0.029
1.762LysAsn: 1.762 ± 0.034
2.492LysPro: 2.492 ± 0.038
2.485LysGln: 2.485 ± 0.044
3.097LysArg: 3.097 ± 0.048
2.867LysSer: 2.867 ± 0.043
2.585LysThr: 2.585 ± 0.041
3.276LysVal: 3.276 ± 0.045
0.759LysTrp: 0.759 ± 0.021
1.6LysTyr: 1.6 ± 0.036
0.0LysXaa: 0.0 ± 0.0
Leu
8.884LeuAla: 8.884 ± 0.091
0.85LeuCys: 0.85 ± 0.022
4.957LeuAsp: 4.957 ± 0.059
5.99LeuGlu: 5.99 ± 0.072
4.571LeuPhe: 4.571 ± 0.06
6.828LeuGly: 6.828 ± 0.078
2.224LeuHis: 2.224 ± 0.035
6.337LeuIle: 6.337 ± 0.071
5.095LeuLys: 5.095 ± 0.056
10.998LeuLeu: 10.998 ± 0.119
2.707LeuMet: 2.707 ± 0.041
3.571LeuAsn: 3.571 ± 0.045
4.608LeuPro: 4.608 ± 0.055
3.96LeuGln: 3.96 ± 0.048
5.339LeuArg: 5.339 ± 0.062
6.737LeuSer: 6.737 ± 0.074
5.533LeuThr: 5.533 ± 0.062
6.143LeuVal: 6.143 ± 0.069
1.134LeuTrp: 1.134 ± 0.026
3.143LeuTyr: 3.143 ± 0.043
0.0LeuXaa: 0.0 ± 0.0
Met
2.386MetAla: 2.386 ± 0.036
0.186MetCys: 0.186 ± 0.011
1.456MetAsp: 1.456 ± 0.03
1.811MetGlu: 1.811 ± 0.033
1.064MetPhe: 1.064 ± 0.025
1.726MetGly: 1.726 ± 0.033
0.524MetHis: 0.524 ± 0.02
1.887MetIle: 1.887 ± 0.031
1.985MetLys: 1.985 ± 0.035
3.11MetLeu: 3.11 ± 0.047
0.875MetMet: 0.875 ± 0.022
1.427MetAsn: 1.427 ± 0.028
1.291MetPro: 1.291 ± 0.028
1.019MetGln: 1.019 ± 0.024
1.514MetArg: 1.514 ± 0.03
1.721MetSer: 1.721 ± 0.027
1.723MetThr: 1.723 ± 0.034
1.637MetVal: 1.637 ± 0.031
0.273MetTrp: 0.273 ± 0.011
0.768MetTyr: 0.768 ± 0.02
0.0MetXaa: 0.0 ± 0.0
Asn
3.123AsnAla: 3.123 ± 0.043
0.285AsnCys: 0.285 ± 0.013
1.906AsnAsp: 1.906 ± 0.041
2.568AsnGlu: 2.568 ± 0.037
1.308AsnPhe: 1.308 ± 0.026
3.416AsnGly: 3.416 ± 0.06
0.813AsnHis: 0.813 ± 0.024
2.116AsnIle: 2.116 ± 0.04
1.805AsnLys: 1.805 ± 0.038
3.02AsnLeu: 3.02 ± 0.044
0.974AsnMet: 0.974 ± 0.025
1.485AsnAsn: 1.485 ± 0.038
1.988AsnPro: 1.988 ± 0.033
1.298AsnGln: 1.298 ± 0.024
2.158AsnArg: 2.158 ± 0.04
1.891AsnSer: 1.891 ± 0.035
1.859AsnThr: 1.859 ± 0.039
2.583AsnVal: 2.583 ± 0.041
0.54AsnTrp: 0.54 ± 0.018
1.372AsnTyr: 1.372 ± 0.031
0.0AsnXaa: 0.0 ± 0.0
Pro
3.895ProAla: 3.895 ± 0.057
0.296ProCys: 0.296 ± 0.013
2.709ProAsp: 2.709 ± 0.038
3.374ProGlu: 3.374 ± 0.045
2.04ProPhe: 2.04 ± 0.037
3.205ProGly: 3.205 ± 0.046
0.968ProHis: 0.968 ± 0.023
2.761ProIle: 2.761 ± 0.04
1.786ProLys: 1.786 ± 0.032
4.093ProLeu: 4.093 ± 0.05
1.071ProMet: 1.071 ± 0.023
1.626ProAsn: 1.626 ± 0.031
1.359ProPro: 1.359 ± 0.033
1.435ProGln: 1.435 ± 0.025
1.64ProArg: 1.64 ± 0.031
2.594ProSer: 2.594 ± 0.038
1.941ProThr: 1.941 ± 0.035
3.304ProVal: 3.304 ± 0.052
0.572ProTrp: 0.572 ± 0.019
1.56ProTyr: 1.56 ± 0.03
0.0ProXaa: 0.0 ± 0.0
Gln
3.421GlnAla: 3.421 ± 0.05
0.222GlnCys: 0.222 ± 0.011
1.633GlnAsp: 1.633 ± 0.027
2.352GlnGlu: 2.352 ± 0.047
1.583GlnPhe: 1.583 ± 0.03
2.496GlnGly: 2.496 ± 0.043
0.841GlnHis: 0.841 ± 0.019
2.259GlnIle: 2.259 ± 0.029
1.633GlnLys: 1.633 ± 0.028
4.307GlnLeu: 4.307 ± 0.061
1.075GlnMet: 1.075 ± 0.024
1.17GlnAsn: 1.17 ± 0.026
1.629GlnPro: 1.629 ± 0.034
1.743GlnGln: 1.743 ± 0.041
1.918GlnArg: 1.918 ± 0.035
2.222GlnSer: 2.222 ± 0.033
1.987GlnThr: 1.987 ± 0.034
2.424GlnVal: 2.424 ± 0.036
0.541GlnTrp: 0.541 ± 0.02
1.237GlnTyr: 1.237 ± 0.026
0.0GlnXaa: 0.0 ± 0.0
Arg
3.828ArgAla: 3.828 ± 0.053
0.431ArgCys: 0.431 ± 0.015
2.549ArgAsp: 2.549 ± 0.038
3.818ArgGlu: 3.818 ± 0.06
2.483ArgPhe: 2.483 ± 0.042
3.347ArgGly: 3.347 ± 0.051
1.175ArgHis: 1.175 ± 0.025
4.031ArgIle: 4.031 ± 0.048
3.095ArgLys: 3.095 ± 0.052
5.59ArgLeu: 5.59 ± 0.069
1.778ArgMet: 1.778 ± 0.035
2.091ArgAsn: 2.091 ± 0.037
1.89ArgPro: 1.89 ± 0.034
2.069ArgGln: 2.069 ± 0.035
2.91ArgArg: 2.91 ± 0.05
3.373ArgSer: 3.373 ± 0.049
2.831ArgThr: 2.831 ± 0.041
3.338ArgVal: 3.338 ± 0.045
0.746ArgTrp: 0.746 ± 0.023
2.013ArgTyr: 2.013 ± 0.036
0.0ArgXaa: 0.0 ± 0.0
Ser
5.275SerAla: 5.275 ± 0.063
0.519SerCys: 0.519 ± 0.016
3.137SerAsp: 3.137 ± 0.046
3.708SerGlu: 3.708 ± 0.041
2.916SerPhe: 2.916 ± 0.042
5.502SerGly: 5.502 ± 0.07
1.205SerHis: 1.205 ± 0.025
4.129SerIle: 4.129 ± 0.053
3.069SerLys: 3.069 ± 0.048
6.063SerLeu: 6.063 ± 0.059
1.734SerMet: 1.734 ± 0.032
2.157SerAsn: 2.157 ± 0.038
2.497SerPro: 2.497 ± 0.036
1.887SerGln: 1.887 ± 0.033
3.152SerArg: 3.152 ± 0.044
3.941SerSer: 3.941 ± 0.056
2.896SerThr: 2.896 ± 0.045
4.414SerVal: 4.414 ± 0.055
0.878SerTrp: 0.878 ± 0.026
2.152SerTyr: 2.152 ± 0.04
0.0SerXaa: 0.0 ± 0.0
Thr
4.873ThrAla: 4.873 ± 0.069
0.389ThrCys: 0.389 ± 0.016
2.8ThrAsp: 2.8 ± 0.043
3.104ThrGlu: 3.104 ± 0.047
2.284ThrPhe: 2.284 ± 0.036
4.46ThrGly: 4.46 ± 0.066
1.014ThrHis: 1.014 ± 0.023
3.784ThrIle: 3.784 ± 0.055
2.357ThrLys: 2.357 ± 0.036
5.121ThrLeu: 5.121 ± 0.054
1.438ThrMet: 1.438 ± 0.03
1.926ThrAsn: 1.926 ± 0.038
2.463ThrPro: 2.463 ± 0.04
1.432ThrGln: 1.432 ± 0.028
2.166ThrArg: 2.166 ± 0.037
3.077ThrSer: 3.077 ± 0.046
2.686ThrThr: 2.686 ± 0.048
4.414ThrVal: 4.414 ± 0.056
0.636ThrTrp: 0.636 ± 0.02
1.818ThrTyr: 1.818 ± 0.034
0.0ThrXaa: 0.0 ± 0.0
Val
5.19ValAla: 5.19 ± 0.065
0.672ValCys: 0.672 ± 0.02
3.573ValAsp: 3.573 ± 0.047
4.204ValGlu: 4.204 ± 0.045
2.936ValPhe: 2.936 ± 0.048
4.496ValGly: 4.496 ± 0.058
1.562ValHis: 1.562 ± 0.031
4.804ValIle: 4.804 ± 0.057
3.733ValLys: 3.733 ± 0.043
6.993ValLeu: 6.993 ± 0.064
1.946ValMet: 1.946 ± 0.035
2.787ValAsn: 2.787 ± 0.046
3.263ValPro: 3.263 ± 0.046
2.537ValGln: 2.537 ± 0.041
3.752ValArg: 3.752 ± 0.049
4.706ValSer: 4.706 ± 0.047
4.32ValThr: 4.32 ± 0.062
4.9ValVal: 4.9 ± 0.066
0.883ValTrp: 0.883 ± 0.025
2.423ValTyr: 2.423 ± 0.043
0.0ValXaa: 0.0 ± 0.0
Trp
0.903TrpAla: 0.903 ± 0.024
0.112TrpCys: 0.112 ± 0.008
0.726TrpAsp: 0.726 ± 0.022
0.784TrpGlu: 0.784 ± 0.022
0.633TrpPhe: 0.633 ± 0.021
0.933TrpGly: 0.933 ± 0.025
0.358TrpHis: 0.358 ± 0.016
0.91TrpIle: 0.91 ± 0.026
0.769TrpLys: 0.769 ± 0.022
1.514TrpLeu: 1.514 ± 0.034
0.437TrpMet: 0.437 ± 0.013
0.693TrpAsn: 0.693 ± 0.022
0.5TrpPro: 0.5 ± 0.018
0.581TrpGln: 0.581 ± 0.02
0.773TrpArg: 0.773 ± 0.021
0.906TrpSer: 0.906 ± 0.023
0.761TrpThr: 0.761 ± 0.021
0.857TrpVal: 0.857 ± 0.02
0.229TrpTrp: 0.229 ± 0.01
0.475TrpTyr: 0.475 ± 0.02
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.842TyrAla: 2.842 ± 0.042
0.338TyrCys: 0.338 ± 0.014
1.876TyrAsp: 1.876 ± 0.034
2.222TyrGlu: 2.222 ± 0.038
1.611TyrPhe: 1.611 ± 0.032
2.795TyrGly: 2.795 ± 0.041
0.737TyrHis: 0.737 ± 0.021
2.027TyrIle: 2.027 ± 0.036
1.605TyrLys: 1.605 ± 0.034
3.328TyrLeu: 3.328 ± 0.04
0.924TyrMet: 0.924 ± 0.022
1.339TyrAsn: 1.339 ± 0.025
1.605TyrPro: 1.605 ± 0.031
1.091TyrGln: 1.091 ± 0.027
2.182TyrArg: 2.182 ± 0.042
1.995TyrSer: 1.995 ± 0.035
1.745TyrThr: 1.745 ± 0.038
2.356TyrVal: 2.356 ± 0.038
0.573TyrTrp: 0.573 ± 0.018
1.335TyrTyr: 1.335 ± 0.028
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5567 proteins (1805433 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski