Amino acid dipepetide frequency for Sulfurimicrobium lacus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	13.878AlaAla: 13.878 ± 0.155	1.226AlaCys: 1.226 ± 0.037	5.612AlaAsp: 5.612 ± 0.07	7.092AlaGlu: 7.092 ± 0.105	3.706AlaPhe: 3.706 ± 0.056	8.903AlaGly: 8.903 ± 0.108	2.452AlaHis: 2.452 ± 0.045	5.614AlaIle: 5.614 ± 0.076	4.422AlaLys: 4.422 ± 0.076	12.757AlaLeu: 12.757 ± 0.136	3.233AlaMet: 3.233 ± 0.05	3.063AlaAsn: 3.063 ± 0.057	4.472AlaPro: 4.472 ± 0.073	4.741AlaGln: 4.741 ± 0.076	6.978AlaArg: 6.978 ± 0.091	5.91AlaSer: 5.91 ± 0.076	5.127AlaThr: 5.127 ± 0.076	7.779AlaVal: 7.779 ± 0.084	1.481AlaTrp: 1.481 ± 0.041	2.597AlaTyr: 2.597 ± 0.05	0.0AlaXaa: 0.0 ± 0.0
Cys	0.989CysAla: 0.989 ± 0.033	0.136CysCys: 0.136 ± 0.011	0.566CysAsp: 0.566 ± 0.027	0.544CysGlu: 0.544 ± 0.022	0.313CysPhe: 0.313 ± 0.017	1.026CysGly: 1.026 ± 0.033	0.431CysHis: 0.431 ± 0.052	0.425CysIle: 0.425 ± 0.022	0.331CysLys: 0.331 ± 0.02	0.89CysLeu: 0.89 ± 0.031	0.22CysMet: 0.22 ± 0.014	0.331CysAsn: 0.331 ± 0.018	0.617CysPro: 0.617 ± 0.025	0.298CysGln: 0.298 ± 0.014	0.65CysArg: 0.65 ± 0.026	0.525CysSer: 0.525 ± 0.026	0.435CysThr: 0.435 ± 0.022	0.646CysVal: 0.646 ± 0.026	0.112CysTrp: 0.112 ± 0.01	0.31CysTyr: 0.31 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	6.039AspAla: 6.039 ± 0.083	0.498AspCys: 0.498 ± 0.02	2.744AspAsp: 2.744 ± 0.055	3.528AspGlu: 3.528 ± 0.056	2.245AspPhe: 2.245 ± 0.042	4.448AspGly: 4.448 ± 0.068	1.058AspHis: 1.058 ± 0.026	3.063AspIle: 3.063 ± 0.057	2.386AspLys: 2.386 ± 0.047	5.522AspLeu: 5.522 ± 0.079	1.409AspMet: 1.409 ± 0.037	1.553AspAsn: 1.553 ± 0.04	2.685AspPro: 2.685 ± 0.056	1.735AspGln: 1.735 ± 0.038	2.936AspArg: 2.936 ± 0.053	2.653AspSer: 2.653 ± 0.06	2.565AspThr: 2.565 ± 0.054	3.651AspVal: 3.651 ± 0.054	0.836AspTrp: 0.836 ± 0.032	1.721AspTyr: 1.721 ± 0.041	0.0AspXaa: 0.0 ± 0.0
Glu	6.744GluAla: 6.744 ± 0.109	0.473GluCys: 0.473 ± 0.023	2.584GluAsp: 2.584 ± 0.051	3.566GluGlu: 3.566 ± 0.093	2.28GluPhe: 2.28 ± 0.047	3.74GluGly: 3.74 ± 0.056	1.546GluHis: 1.546 ± 0.038	3.851GluIle: 3.851 ± 0.065	3.147GluLys: 3.147 ± 0.07	6.489GluLeu: 6.489 ± 0.089	1.803GluMet: 1.803 ± 0.048	2.059GluAsn: 2.059 ± 0.042	2.202GluPro: 2.202 ± 0.048	3.135GluGln: 3.135 ± 0.056	4.547GluArg: 4.547 ± 0.083	3.11GluSer: 3.11 ± 0.054	3.142GluThr: 3.142 ± 0.052	4.217GluVal: 4.217 ± 0.071	0.827GluTrp: 0.827 ± 0.031	1.408GluTyr: 1.408 ± 0.037	0.0GluXaa: 0.0 ± 0.0
Phe	4.042PheAla: 4.042 ± 0.058	0.414PheCys: 0.414 ± 0.019	2.499PheAsp: 2.499 ± 0.045	2.185PheGlu: 2.185 ± 0.046	1.547PhePhe: 1.547 ± 0.04	3.238PheGly: 3.238 ± 0.058	0.884PheHis: 0.884 ± 0.028	1.863PheIle: 1.863 ± 0.036	1.4PheLys: 1.4 ± 0.035	3.44PheLeu: 3.44 ± 0.061	0.968PheMet: 0.968 ± 0.031	1.308PheAsn: 1.308 ± 0.039	1.667PhePro: 1.667 ± 0.038	1.186PheGln: 1.186 ± 0.033	2.015PheArg: 2.015 ± 0.044	2.594PheSer: 2.594 ± 0.037	1.904PheThr: 1.904 ± 0.035	2.631PheVal: 2.631 ± 0.05	0.556PheTrp: 0.556 ± 0.024	1.123PheTyr: 1.123 ± 0.032	0.0PheXaa: 0.0 ± 0.0
Gly	7.466GlyAla: 7.466 ± 0.099	0.925GlyCys: 0.925 ± 0.033	3.993GlyAsp: 3.993 ± 0.068	4.914GlyGlu: 4.914 ± 0.07	3.258GlyPhe: 3.258 ± 0.054	6.298GlyGly: 6.298 ± 0.123	1.852GlyHis: 1.852 ± 0.042	4.36GlyIle: 4.36 ± 0.065	4.439GlyLys: 4.439 ± 0.066	7.981GlyLeu: 7.981 ± 0.084	2.535GlyMet: 2.535 ± 0.048	2.499GlyAsn: 2.499 ± 0.074	2.291GlyPro: 2.291 ± 0.046	2.961GlyGln: 2.961 ± 0.055	4.625GlyArg: 4.625 ± 0.062	4.192GlySer: 4.192 ± 0.074	3.919GlyThr: 3.919 ± 0.084	5.949GlyVal: 5.949 ± 0.081	1.196GlyTrp: 1.196 ± 0.037	2.514GlyTyr: 2.514 ± 0.052	0.0GlyXaa: 0.0 ± 0.0
His	2.558HisAla: 2.558 ± 0.048	0.29HisCys: 0.29 ± 0.014	1.367HisAsp: 1.367 ± 0.038	1.39HisGlu: 1.39 ± 0.034	1.067HisPhe: 1.067 ± 0.033	1.985HisGly: 1.985 ± 0.053	0.79HisHis: 0.79 ± 0.027	1.205HisIle: 1.205 ± 0.035	0.802HisLys: 0.802 ± 0.027	2.499HisLeu: 2.499 ± 0.045	0.534HisMet: 0.534 ± 0.021	0.688HisAsn: 0.688 ± 0.028	1.518HisPro: 1.518 ± 0.033	0.923HisGln: 0.923 ± 0.03	1.346HisArg: 1.346 ± 0.035	1.216HisSer: 1.216 ± 0.036	1.037HisThr: 1.037 ± 0.031	1.504HisVal: 1.504 ± 0.038	0.352HisTrp: 0.352 ± 0.018	0.818HisTyr: 0.818 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	6.116IleAla: 6.116 ± 0.079	0.474IleCys: 0.474 ± 0.02	3.024IleAsp: 3.024 ± 0.054	3.473IleGlu: 3.473 ± 0.065	1.712IlePhe: 1.712 ± 0.036	4.4IleGly: 4.4 ± 0.066	1.18IleHis: 1.18 ± 0.034	2.252IleIle: 2.252 ± 0.05	2.141IleLys: 2.141 ± 0.051	4.763IleLeu: 4.763 ± 0.06	1.126IleMet: 1.126 ± 0.033	1.832IleAsn: 1.832 ± 0.043	2.552IlePro: 2.552 ± 0.052	1.636IleGln: 1.636 ± 0.033	3.083IleArg: 3.083 ± 0.051	3.204IleSer: 3.204 ± 0.056	2.803IleThr: 2.803 ± 0.055	3.742IleVal: 3.742 ± 0.062	0.536IleTrp: 0.536 ± 0.023	1.264IleTyr: 1.264 ± 0.032	0.0IleXaa: 0.0 ± 0.0
Lys	4.329LysAla: 4.329 ± 0.078	0.3LysCys: 0.3 ± 0.019	2.124LysAsp: 2.124 ± 0.05	2.377LysGlu: 2.377 ± 0.054	1.288LysPhe: 1.288 ± 0.035	2.89LysGly: 2.89 ± 0.062	0.968LysHis: 0.968 ± 0.032	2.465LysIle: 2.465 ± 0.05	2.052LysLys: 2.052 ± 0.049	4.613LysLeu: 4.613 ± 0.073	1.259LysMet: 1.259 ± 0.032	1.531LysAsn: 1.531 ± 0.036	2.375LysPro: 2.375 ± 0.052	1.862LysGln: 1.862 ± 0.039	2.619LysArg: 2.619 ± 0.05	2.324LysSer: 2.324 ± 0.054	2.398LysThr: 2.398 ± 0.057	2.933LysVal: 2.933 ± 0.049	0.461LysTrp: 0.461 ± 0.021	0.95LysTyr: 0.95 ± 0.029	0.0LysXaa: 0.0 ± 0.0
Leu	13.278LeuAla: 13.278 ± 0.13	0.98LeuCys: 0.98 ± 0.026	6.031LeuAsp: 6.031 ± 0.084	6.43LeuGlu: 6.43 ± 0.096	3.944LeuPhe: 3.944 ± 0.059	8.285LeuGly: 8.285 ± 0.088	2.485LeuHis: 2.485 ± 0.059	4.917LeuIle: 4.917 ± 0.066	4.71LeuLys: 4.71 ± 0.083	11.84LeuLeu: 11.84 ± 0.145	2.499LeuMet: 2.499 ± 0.048	3.341LeuAsn: 3.341 ± 0.054	5.77LeuPro: 5.77 ± 0.08	4.162LeuGln: 4.162 ± 0.059	6.816LeuArg: 6.816 ± 0.092	6.535LeuSer: 6.535 ± 0.074	5.458LeuThr: 5.458 ± 0.07	7.281LeuVal: 7.281 ± 0.09	1.189LeuTrp: 1.189 ± 0.041	2.357LeuTyr: 2.357 ± 0.048	0.0LeuXaa: 0.0 ± 0.0
Met	2.952MetAla: 2.952 ± 0.054	0.17MetCys: 0.17 ± 0.012	1.399MetAsp: 1.399 ± 0.037	1.526MetGlu: 1.526 ± 0.037	0.781MetPhe: 0.781 ± 0.028	1.862MetGly: 1.862 ± 0.043	0.596MetHis: 0.596 ± 0.021	1.208MetIle: 1.208 ± 0.035	1.392MetLys: 1.392 ± 0.036	2.963MetLeu: 2.963 ± 0.051	0.663MetMet: 0.663 ± 0.024	0.977MetAsn: 0.977 ± 0.034	1.403MetPro: 1.403 ± 0.036	1.172MetGln: 1.172 ± 0.036	1.717MetArg: 1.717 ± 0.042	1.662MetSer: 1.662 ± 0.043	1.42MetThr: 1.42 ± 0.035	1.82MetVal: 1.82 ± 0.046	0.243MetTrp: 0.243 ± 0.017	0.45MetTyr: 0.45 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	3.256AsnAla: 3.256 ± 0.055	0.348AsnCys: 0.348 ± 0.016	1.578AsnAsp: 1.578 ± 0.054	1.617AsnGlu: 1.617 ± 0.037	1.164AsnPhe: 1.164 ± 0.032	2.574AsnGly: 2.574 ± 0.053	0.715AsnHis: 0.715 ± 0.031	1.743AsnIle: 1.743 ± 0.039	1.181AsnLys: 1.181 ± 0.037	3.513AsnLeu: 3.513 ± 0.054	0.801AsnMet: 0.801 ± 0.026	1.051AsnAsn: 1.051 ± 0.036	2.103AsnPro: 2.103 ± 0.042	1.225AsnGln: 1.225 ± 0.034	1.952AsnArg: 1.952 ± 0.045	1.619AsnSer: 1.619 ± 0.045	1.542AsnThr: 1.542 ± 0.045	2.129AsnVal: 2.129 ± 0.044	0.465AsnTrp: 0.465 ± 0.021	0.888AsnTyr: 0.888 ± 0.031	0.0AsnXaa: 0.0 ± 0.0
Pro	5.413ProAla: 5.413 ± 0.073	0.404ProCys: 0.404 ± 0.021	3.124ProAsp: 3.124 ± 0.052	3.506ProGlu: 3.506 ± 0.061	1.767ProPhe: 1.767 ± 0.041	3.876ProGly: 3.876 ± 0.063	1.101ProHis: 1.101 ± 0.034	1.962ProIle: 1.962 ± 0.047	1.646ProLys: 1.646 ± 0.038	5.113ProLeu: 5.113 ± 0.078	1.1ProMet: 1.1 ± 0.03	1.345ProAsn: 1.345 ± 0.036	2.235ProPro: 2.235 ± 0.053	1.951ProGln: 1.951 ± 0.044	2.334ProArg: 2.334 ± 0.048	2.418ProSer: 2.418 ± 0.042	2.106ProThr: 2.106 ± 0.046	3.943ProVal: 3.943 ± 0.055	0.667ProTrp: 0.667 ± 0.025	1.291ProTyr: 1.291 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	4.88GlnAla: 4.88 ± 0.072	0.342GlnCys: 0.342 ± 0.03	1.878GlnAsp: 1.878 ± 0.04	2.377GlnGlu: 2.377 ± 0.053	1.358GlnPhe: 1.358 ± 0.033	3.054GlnGly: 3.054 ± 0.049	1.058GlnHis: 1.058 ± 0.035	2.041GlnIle: 2.041 ± 0.047	1.506GlnLys: 1.506 ± 0.035	4.166GlnLeu: 4.166 ± 0.064	1.051GlnMet: 1.051 ± 0.034	1.136GlnAsn: 1.136 ± 0.029	1.993GlnPro: 1.993 ± 0.043	2.119GlnGln: 2.119 ± 0.057	2.89GlnArg: 2.89 ± 0.06	2.138GlnSer: 2.138 ± 0.042	1.887GlnThr: 1.887 ± 0.042	2.98GlnVal: 2.98 ± 0.05	0.48GlnTrp: 0.48 ± 0.02	0.908GlnTyr: 0.908 ± 0.031	0.0GlnXaa: 0.0 ± 0.0
Arg	5.957ArgAla: 5.957 ± 0.084	0.547ArgCys: 0.547 ± 0.023	3.522ArgAsp: 3.522 ± 0.058	4.353ArgGlu: 4.353 ± 0.076	2.769ArgPhe: 2.769 ± 0.049	3.825ArgGly: 3.825 ± 0.06	1.799ArgHis: 1.799 ± 0.042	3.703ArgIle: 3.703 ± 0.056	2.628ArgLys: 2.628 ± 0.052	7.165ArgLeu: 7.165 ± 0.087	1.814ArgMet: 1.814 ± 0.038	2.111ArgAsn: 2.111 ± 0.049	2.498ArgPro: 2.498 ± 0.046	2.861ArgGln: 2.861 ± 0.048	4.251ArgArg: 4.251 ± 0.072	3.048ArgSer: 3.048 ± 0.05	2.702ArgThr: 2.702 ± 0.049	4.248ArgVal: 4.248 ± 0.069	0.927ArgTrp: 0.927 ± 0.031	1.878ArgTyr: 1.878 ± 0.043	0.0ArgXaa: 0.0 ± 0.0
Ser	6.013SerAla: 6.013 ± 0.075	0.589SerCys: 0.589 ± 0.03	2.843SerAsp: 2.843 ± 0.055	3.008SerGlu: 3.008 ± 0.052	2.19SerPhe: 2.19 ± 0.038	5.544SerGly: 5.544 ± 0.073	1.355SerHis: 1.355 ± 0.032	2.74SerIle: 2.74 ± 0.05	1.972SerLys: 1.972 ± 0.048	6.049SerLeu: 6.049 ± 0.084	1.444SerMet: 1.444 ± 0.041	1.671SerAsn: 1.671 ± 0.038	2.701SerPro: 2.701 ± 0.053	2.05SerGln: 2.05 ± 0.048	3.503SerArg: 3.503 ± 0.057	3.292SerSer: 3.292 ± 0.065	2.62SerThr: 2.62 ± 0.063	3.848SerVal: 3.848 ± 0.063	0.745SerTrp: 0.745 ± 0.029	1.457SerTyr: 1.457 ± 0.036	0.0SerXaa: 0.0 ± 0.0
Thr	5.125ThrAla: 5.125 ± 0.086	0.519ThrCys: 0.519 ± 0.036	2.427ThrAsp: 2.427 ± 0.047	2.509ThrGlu: 2.509 ± 0.045	1.718ThrPhe: 1.718 ± 0.035	4.337ThrGly: 4.337 ± 0.074	1.182ThrHis: 1.182 ± 0.036	2.422ThrIle: 2.422 ± 0.05	1.469ThrLys: 1.469 ± 0.042	6.229ThrLeu: 6.229 ± 0.082	1.122ThrMet: 1.122 ± 0.032	1.334ThrAsn: 1.334 ± 0.037	3.081ThrPro: 3.081 ± 0.052	1.856ThrGln: 1.856 ± 0.045	2.957ThrArg: 2.957 ± 0.048	2.666ThrSer: 2.666 ± 0.056	2.625ThrThr: 2.625 ± 0.055	3.988ThrVal: 3.988 ± 0.057	0.617ThrTrp: 0.617 ± 0.025	1.24ThrTyr: 1.24 ± 0.039	0.0ThrXaa: 0.0 ± 0.0
Val	8.333ValAla: 8.333 ± 0.091	0.712ValCys: 0.712 ± 0.025	3.959ValAsp: 3.959 ± 0.059	4.535ValGlu: 4.535 ± 0.073	2.734ValPhe: 2.734 ± 0.049	4.939ValGly: 4.939 ± 0.073	1.442ValHis: 1.442 ± 0.034	3.888ValIle: 3.888 ± 0.057	3.093ValLys: 3.093 ± 0.053	7.46ValLeu: 7.46 ± 0.094	1.945ValMet: 1.945 ± 0.042	2.361ValAsn: 2.361 ± 0.05	3.233ValPro: 3.233 ± 0.057	2.311ValGln: 2.311 ± 0.041	4.269ValArg: 4.269 ± 0.062	4.317ValSer: 4.317 ± 0.06	3.909ValThr: 3.909 ± 0.062	5.592ValVal: 5.592 ± 0.078	0.9ValTrp: 0.9 ± 0.027	1.669ValTyr: 1.669 ± 0.04	0.0ValXaa: 0.0 ± 0.0
Trp	1.058TrpAla: 1.058 ± 0.034	0.147TrpCys: 0.147 ± 0.01	0.628TrpAsp: 0.628 ± 0.025	0.655TrpGlu: 0.655 ± 0.025	0.517TrpPhe: 0.517 ± 0.023	0.849TrpGly: 0.849 ± 0.03	0.368TrpHis: 0.368 ± 0.02	0.6TrpIle: 0.6 ± 0.023	0.545TrpLys: 0.545 ± 0.02	1.933TrpLeu: 1.933 ± 0.05	0.353TrpMet: 0.353 ± 0.017	0.466TrpAsn: 0.466 ± 0.02	0.566TrpPro: 0.566 ± 0.025	0.807TrpGln: 0.807 ± 0.026	1.041TrpArg: 1.041 ± 0.039	0.706TrpSer: 0.706 ± 0.024	0.539TrpThr: 0.539 ± 0.022	0.956TrpVal: 0.956 ± 0.032	0.212TrpTrp: 0.212 ± 0.014	0.28TrpTyr: 0.28 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.619TyrAla: 2.619 ± 0.049	0.3TyrCys: 0.3 ± 0.017	1.373TyrAsp: 1.373 ± 0.041	1.285TyrGlu: 1.285 ± 0.038	1.106TyrPhe: 1.106 ± 0.032	2.095TyrGly: 2.095 ± 0.05	0.628TyrHis: 0.628 ± 0.025	0.99TyrIle: 0.99 ± 0.032	0.855TyrLys: 0.855 ± 0.028	2.924TyrLeu: 2.924 ± 0.049	0.497TyrMet: 0.497 ± 0.02	0.806TyrAsn: 0.806 ± 0.029	1.339TyrPro: 1.339 ± 0.031	1.253TyrGln: 1.253 ± 0.037	2.079TyrArg: 2.079 ± 0.044	1.507TyrSer: 1.507 ± 0.043	1.284TyrThr: 1.284 ± 0.035	1.761TyrVal: 1.761 ± 0.037	0.421TyrTrp: 0.421 ± 0.023	0.775TyrTyr: 0.775 ± 0.031	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3673 proteins (1167837 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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