Amino acid dipepetide frequency for Cobetia sp. UCD-24C

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	13.163AlaAla: 13.163 ± 0.152	1.306AlaCys: 1.306 ± 0.035	6.06AlaAsp: 6.06 ± 0.102	7.342AlaGlu: 7.342 ± 0.085	3.725AlaPhe: 3.725 ± 0.07	9.369AlaGly: 9.369 ± 0.115	2.354AlaHis: 2.354 ± 0.051	5.501AlaIle: 5.501 ± 0.078	2.762AlaLys: 2.762 ± 0.065	13.922AlaLeu: 13.922 ± 0.16	3.406AlaMet: 3.406 ± 0.065	2.945AlaAsn: 2.945 ± 0.05	5.169AlaPro: 5.169 ± 0.087	4.346AlaGln: 4.346 ± 0.085	8.394AlaArg: 8.394 ± 0.131	7.293AlaSer: 7.293 ± 0.098	5.658AlaThr: 5.658 ± 0.095	7.277AlaVal: 7.277 ± 0.09	1.64AlaTrp: 1.64 ± 0.047	2.218AlaTyr: 2.218 ± 0.053	0.001AlaXaa: 0.001 ± 0.001
Cys	1.005CysAla: 1.005 ± 0.033	0.142CysCys: 0.142 ± 0.014	0.603CysAsp: 0.603 ± 0.027	0.674CysGlu: 0.674 ± 0.028	0.349CysPhe: 0.349 ± 0.021	0.983CysGly: 0.983 ± 0.033	0.319CysHis: 0.319 ± 0.019	0.416CysIle: 0.416 ± 0.02	0.205CysLys: 0.205 ± 0.014	1.103CysLeu: 1.103 ± 0.037	0.237CysMet: 0.237 ± 0.015	0.218CysAsn: 0.218 ± 0.015	0.494CysPro: 0.494 ± 0.022	0.414CysGln: 0.414 ± 0.022	0.632CysArg: 0.632 ± 0.025	0.496CysSer: 0.496 ± 0.025	0.404CysThr: 0.404 ± 0.02	0.684CysVal: 0.684 ± 0.025	0.153CysTrp: 0.153 ± 0.014	0.29CysTyr: 0.29 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	6.866AspAla: 6.866 ± 0.137	0.545AspCys: 0.545 ± 0.022	3.786AspAsp: 3.786 ± 0.091	3.879AspGlu: 3.879 ± 0.066	2.161AspPhe: 2.161 ± 0.051	4.878AspGly: 4.878 ± 0.15	1.363AspHis: 1.363 ± 0.034	3.075AspIle: 3.075 ± 0.063	1.786AspLys: 1.786 ± 0.04	5.112AspLeu: 5.112 ± 0.078	1.453AspMet: 1.453 ± 0.036	1.735AspAsn: 1.735 ± 0.055	2.642AspPro: 2.642 ± 0.054	1.955AspGln: 1.955 ± 0.042	2.878AspArg: 2.878 ± 0.054	3.648AspSer: 3.648 ± 0.099	3.07AspThr: 3.07 ± 0.106	3.986AspVal: 3.986 ± 0.081	1.074AspTrp: 1.074 ± 0.038	1.733AspTyr: 1.733 ± 0.042	0.001AspXaa: 0.001 ± 0.001
Glu	7.699GluAla: 7.699 ± 0.104	0.555GluCys: 0.555 ± 0.02	3.276GluAsp: 3.276 ± 0.063	3.817GluGlu: 3.817 ± 0.07	1.705GluPhe: 1.705 ± 0.039	4.93GluGly: 4.93 ± 0.073	1.797GluHis: 1.797 ± 0.046	2.944GluIle: 2.944 ± 0.052	1.864GluLys: 1.864 ± 0.053	6.824GluLeu: 6.824 ± 0.088	1.58GluMet: 1.58 ± 0.046	1.427GluAsn: 1.427 ± 0.038	2.276GluPro: 2.276 ± 0.046	3.511GluGln: 3.511 ± 0.065	5.366GluArg: 5.366 ± 0.085	3.382GluSer: 3.382 ± 0.057	3.093GluThr: 3.093 ± 0.068	4.763GluVal: 4.763 ± 0.066	0.94GluTrp: 0.94 ± 0.031	1.283GluTyr: 1.283 ± 0.041	0.0GluXaa: 0.0 ± 0.0
Phe	3.686PheAla: 3.686 ± 0.067	0.383PheCys: 0.383 ± 0.021	2.342PheAsp: 2.342 ± 0.052	2.025PheGlu: 2.025 ± 0.045	1.249PhePhe: 1.249 ± 0.039	3.224PheGly: 3.224 ± 0.066	0.77PheHis: 0.77 ± 0.031	1.743PheIle: 1.743 ± 0.052	0.979PheLys: 0.979 ± 0.036	2.994PheLeu: 2.994 ± 0.065	0.934PheMet: 0.934 ± 0.032	1.126PheAsn: 1.126 ± 0.037	1.362PhePro: 1.362 ± 0.038	1.03PheGln: 1.03 ± 0.033	1.708PheArg: 1.708 ± 0.045	2.409PheSer: 2.409 ± 0.048	2.105PheThr: 2.105 ± 0.05	2.478PheVal: 2.478 ± 0.05	0.459PheTrp: 0.459 ± 0.025	0.904PheTyr: 0.904 ± 0.033	0.0PheXaa: 0.0 ± 0.0
Gly	7.603GlyAla: 7.603 ± 0.095	0.947GlyCys: 0.947 ± 0.033	4.59GlyAsp: 4.59 ± 0.089	5.7GlyGlu: 5.7 ± 0.092	3.073GlyPhe: 3.073 ± 0.063	6.43GlyGly: 6.43 ± 0.104	2.049GlyHis: 2.049 ± 0.049	4.663GlyIle: 4.663 ± 0.081	2.927GlyLys: 2.927 ± 0.059	9.377GlyLeu: 9.377 ± 0.11	2.669GlyMet: 2.669 ± 0.051	2.301GlyAsn: 2.301 ± 0.067	2.65GlyPro: 2.65 ± 0.051	3.227GlyGln: 3.227 ± 0.062	4.988GlyArg: 4.988 ± 0.093	4.632GlySer: 4.632 ± 0.071	3.901GlyThr: 3.901 ± 0.112	6.47GlyVal: 6.47 ± 0.082	1.351GlyTrp: 1.351 ± 0.039	2.297GlyTyr: 2.297 ± 0.053	0.0GlyXaa: 0.0 ± 0.0
His	2.762HisAla: 2.762 ± 0.061	0.311HisCys: 0.311 ± 0.019	1.607HisAsp: 1.607 ± 0.043	1.438HisGlu: 1.438 ± 0.039	0.97HisPhe: 0.97 ± 0.035	2.124HisGly: 2.124 ± 0.05	0.838HisHis: 0.838 ± 0.032	0.883HisIle: 0.883 ± 0.03	0.545HisLys: 0.545 ± 0.023	2.648HisLeu: 2.648 ± 0.057	0.53HisMet: 0.53 ± 0.022	0.58HisAsn: 0.58 ± 0.024	1.493HisPro: 1.493 ± 0.041	1.097HisGln: 1.097 ± 0.031	1.489HisArg: 1.489 ± 0.039	1.192HisSer: 1.192 ± 0.034	0.992HisThr: 0.992 ± 0.033	1.527HisVal: 1.527 ± 0.038	0.444HisTrp: 0.444 ± 0.021	0.723HisTyr: 0.723 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	6.151IleAla: 6.151 ± 0.085	0.456IleCys: 0.456 ± 0.021	3.286IleAsp: 3.286 ± 0.065	3.468IleGlu: 3.468 ± 0.065	1.521IlePhe: 1.521 ± 0.043	4.527IleGly: 4.527 ± 0.083	1.038IleHis: 1.038 ± 0.031	2.334IleIle: 2.334 ± 0.056	1.475IleLys: 1.475 ± 0.042	4.002IleLeu: 4.002 ± 0.072	0.924IleMet: 0.924 ± 0.035	1.593IleAsn: 1.593 ± 0.05	2.099IlePro: 2.099 ± 0.049	1.474IleGln: 1.474 ± 0.037	2.788IleArg: 2.788 ± 0.053	3.156IleSer: 3.156 ± 0.055	3.06IleThr: 3.06 ± 0.099	3.286IleVal: 3.286 ± 0.07	0.447IleTrp: 0.447 ± 0.021	1.06IleTyr: 1.06 ± 0.036	0.0IleXaa: 0.0 ± 0.0
Lys	3.57LysAla: 3.57 ± 0.086	0.166LysCys: 0.166 ± 0.012	1.535LysAsp: 1.535 ± 0.042	1.511LysGlu: 1.511 ± 0.048	0.65LysPhe: 0.65 ± 0.026	2.451LysGly: 2.451 ± 0.056	0.617LysHis: 0.617 ± 0.028	1.225LysIle: 1.225 ± 0.038	1.008LysLys: 1.008 ± 0.039	2.959LysLeu: 2.959 ± 0.059	0.697LysMet: 0.697 ± 0.029	0.621LysAsn: 0.621 ± 0.025	1.555LysPro: 1.555 ± 0.041	1.286LysGln: 1.286 ± 0.037	2.322LysArg: 2.322 ± 0.053	1.607LysSer: 1.607 ± 0.045	1.512LysThr: 1.512 ± 0.042	2.357LysVal: 2.357 ± 0.049	0.295LysTrp: 0.295 ± 0.018	0.531LysTyr: 0.531 ± 0.024	0.0LysXaa: 0.0 ± 0.0
Leu	14.43LeuAla: 14.43 ± 0.174	1.215LeuCys: 1.215 ± 0.038	6.799LeuAsp: 6.799 ± 0.098	7.82LeuGlu: 7.82 ± 0.094	3.647LeuPhe: 3.647 ± 0.074	9.35LeuGly: 9.35 ± 0.123	2.258LeuHis: 2.258 ± 0.052	5.646LeuIle: 5.646 ± 0.086	4.102LeuLys: 4.102 ± 0.074	11.868LeuLeu: 11.868 ± 0.196	3.15LeuMet: 3.15 ± 0.057	3.076LeuAsn: 3.076 ± 0.052	6.036LeuPro: 6.036 ± 0.088	2.855LeuGln: 2.855 ± 0.055	6.248LeuArg: 6.248 ± 0.095	7.677LeuSer: 7.677 ± 0.098	6.146LeuThr: 6.146 ± 0.104	7.734LeuVal: 7.734 ± 0.113	1.487LeuTrp: 1.487 ± 0.043	2.344LeuTyr: 2.344 ± 0.051	0.0LeuXaa: 0.0 ± 0.0
Met	3.392MetAla: 3.392 ± 0.055	0.185MetCys: 0.185 ± 0.015	1.162MetAsp: 1.162 ± 0.035	1.249MetGlu: 1.249 ± 0.036	0.722MetPhe: 0.722 ± 0.03	2.07MetGly: 2.07 ± 0.053	0.542MetHis: 0.542 ± 0.02	1.326MetIle: 1.326 ± 0.045	0.902MetLys: 0.902 ± 0.033	3.046MetLeu: 3.046 ± 0.064	0.749MetMet: 0.749 ± 0.029	0.777MetAsn: 0.777 ± 0.029	1.503MetPro: 1.503 ± 0.034	1.155MetGln: 1.155 ± 0.032	1.652MetArg: 1.652 ± 0.042	1.966MetSer: 1.966 ± 0.046	1.812MetThr: 1.812 ± 0.045	1.842MetVal: 1.842 ± 0.046	0.237MetTrp: 0.237 ± 0.015	0.345MetTyr: 0.345 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	3.13AsnAla: 3.13 ± 0.057	0.233AsnCys: 0.233 ± 0.014	1.679AsnAsp: 1.679 ± 0.071	1.393AsnGlu: 1.393 ± 0.036	0.953AsnPhe: 0.953 ± 0.033	2.282AsnGly: 2.282 ± 0.066	0.608AsnHis: 0.608 ± 0.025	1.288AsnIle: 1.288 ± 0.038	0.605AsnLys: 0.605 ± 0.027	2.882AsnLeu: 2.882 ± 0.049	0.601AsnMet: 0.601 ± 0.024	0.666AsnAsn: 0.666 ± 0.027	1.608AsnPro: 1.608 ± 0.041	0.964AsnGln: 0.964 ± 0.027	1.617AsnArg: 1.617 ± 0.035	1.35AsnSer: 1.35 ± 0.038	1.331AsnThr: 1.331 ± 0.042	1.856AsnVal: 1.856 ± 0.064	0.369AsnTrp: 0.369 ± 0.024	0.639AsnTyr: 0.639 ± 0.025	0.001AsnXaa: 0.001 ± 0.001
Pro	5.361ProAla: 5.361 ± 0.082	0.36ProCys: 0.36 ± 0.02	3.025ProAsp: 3.025 ± 0.06	3.651ProGlu: 3.651 ± 0.062	1.635ProPhe: 1.635 ± 0.042	3.844ProGly: 3.844 ± 0.061	1.114ProHis: 1.114 ± 0.033	1.914ProIle: 1.914 ± 0.046	1.182ProLys: 1.182 ± 0.04	5.737ProLeu: 5.737 ± 0.084	1.149ProMet: 1.149 ± 0.035	1.113ProAsn: 1.113 ± 0.03	1.801ProPro: 1.801 ± 0.046	1.995ProGln: 1.995 ± 0.045	2.815ProArg: 2.815 ± 0.06	2.772ProSer: 2.772 ± 0.06	2.283ProThr: 2.283 ± 0.049	3.647ProVal: 3.647 ± 0.066	0.76ProTrp: 0.76 ± 0.029	1.043ProTyr: 1.043 ± 0.028	0.0ProXaa: 0.0 ± 0.0
Gln	5.286GlnAla: 5.286 ± 0.083	0.319GlnCys: 0.319 ± 0.02	1.845GlnAsp: 1.845 ± 0.043	1.913GlnGlu: 1.913 ± 0.046	1.112GlnPhe: 1.112 ± 0.03	3.146GlnGly: 3.146 ± 0.057	1.12GlnHis: 1.12 ± 0.033	1.601GlnIle: 1.601 ± 0.039	0.952GlnLys: 0.952 ± 0.034	4.661GlnLeu: 4.661 ± 0.084	0.977GlnMet: 0.977 ± 0.03	0.742GlnAsn: 0.742 ± 0.029	2.046GlnPro: 2.046 ± 0.05	2.499GlnGln: 2.499 ± 0.063	3.209GlnArg: 3.209 ± 0.067	2.024GlnSer: 2.024 ± 0.051	1.723GlnThr: 1.723 ± 0.046	2.945GlnVal: 2.945 ± 0.053	0.622GlnTrp: 0.622 ± 0.027	0.807GlnTyr: 0.807 ± 0.029	0.0GlnXaa: 0.0 ± 0.0
Arg	6.17ArgAla: 6.17 ± 0.088	0.586ArgCys: 0.586 ± 0.023	3.952ArgAsp: 3.952 ± 0.068	5.083ArgGlu: 5.083 ± 0.094	2.614ArgPhe: 2.614 ± 0.058	4.271ArgGly: 4.271 ± 0.063	2.245ArgHis: 2.245 ± 0.05	3.29ArgIle: 3.29 ± 0.061	1.894ArgLys: 1.894 ± 0.046	8.793ArgLeu: 8.793 ± 0.134	1.801ArgMet: 1.801 ± 0.043	1.548ArgAsn: 1.548 ± 0.042	2.654ArgPro: 2.654 ± 0.059	3.222ArgGln: 3.222 ± 0.071	4.764ArgArg: 4.764 ± 0.087	3.216ArgSer: 3.216 ± 0.062	2.626ArgThr: 2.626 ± 0.058	4.415ArgVal: 4.415 ± 0.08	1.074ArgTrp: 1.074 ± 0.032	1.947ArgTyr: 1.947 ± 0.044	0.0ArgXaa: 0.0 ± 0.0
Ser	6.362SerAla: 6.362 ± 0.098	0.493SerCys: 0.493 ± 0.025	3.498SerAsp: 3.498 ± 0.081	3.64SerGlu: 3.64 ± 0.064	2.185SerPhe: 2.185 ± 0.049	5.568SerGly: 5.568 ± 0.077	1.484SerHis: 1.484 ± 0.039	2.45SerIle: 2.45 ± 0.059	1.313SerLys: 1.313 ± 0.04	7.561SerLeu: 7.561 ± 0.1	1.571SerMet: 1.571 ± 0.042	1.506SerAsn: 1.506 ± 0.061	2.946SerPro: 2.946 ± 0.057	2.328SerGln: 2.328 ± 0.049	4.431SerArg: 4.431 ± 0.07	3.53SerSer: 3.53 ± 0.074	2.86SerThr: 2.86 ± 0.059	4.14SerVal: 4.14 ± 0.077	0.894SerTrp: 0.894 ± 0.031	1.342SerTyr: 1.342 ± 0.045	0.001SerXaa: 0.001 ± 0.001
Thr	5.578ThrAla: 5.578 ± 0.106	0.459ThrCys: 0.459 ± 0.018	2.814ThrAsp: 2.814 ± 0.145	2.338ThrGlu: 2.338 ± 0.059	1.821ThrPhe: 1.821 ± 0.05	4.504ThrGly: 4.504 ± 0.089	1.246ThrHis: 1.246 ± 0.037	2.125ThrIle: 2.125 ± 0.071	0.891ThrLys: 0.891 ± 0.033	7.454ThrLeu: 7.454 ± 0.112	0.939ThrMet: 0.939 ± 0.029	1.168ThrAsn: 1.168 ± 0.047	3.657ThrPro: 3.657 ± 0.062	1.916ThrGln: 1.916 ± 0.046	3.757ThrArg: 3.757 ± 0.062	3.012ThrSer: 3.012 ± 0.059	2.774ThrThr: 2.774 ± 0.089	3.335ThrVal: 3.335 ± 0.107	0.6ThrTrp: 0.6 ± 0.027	1.009ThrTyr: 1.009 ± 0.041	0.001ThrXaa: 0.001 ± 0.001
Val	8.099ValAla: 8.099 ± 0.09	0.738ValCys: 0.738 ± 0.027	3.935ValAsp: 3.935 ± 0.082	4.442ValGlu: 4.442 ± 0.064	2.423ValPhe: 2.423 ± 0.061	5.047ValGly: 5.047 ± 0.072	1.403ValHis: 1.403 ± 0.038	4.241ValIle: 4.241 ± 0.069	2.092ValLys: 2.092 ± 0.048	7.695ValLeu: 7.695 ± 0.105	2.37ValMet: 2.37 ± 0.05	1.998ValAsn: 1.998 ± 0.048	3.262ValPro: 3.262 ± 0.05	2.071ValGln: 2.071 ± 0.044	4.131ValArg: 4.131 ± 0.062	4.626ValSer: 4.626 ± 0.077	4.281ValThr: 4.281 ± 0.125	5.678ValVal: 5.678 ± 0.1	0.888ValTrp: 0.888 ± 0.031	1.41ValTyr: 1.41 ± 0.042	0.001ValXaa: 0.001 ± 0.001
Trp	1.136TrpAla: 1.136 ± 0.036	0.175TrpCys: 0.175 ± 0.013	0.582TrpAsp: 0.582 ± 0.026	0.612TrpGlu: 0.612 ± 0.027	0.5TrpPhe: 0.5 ± 0.021	0.94TrpGly: 0.94 ± 0.035	0.409TrpHis: 0.409 ± 0.02	0.645TrpIle: 0.645 ± 0.029	0.438TrpLys: 0.438 ± 0.019	2.433TrpLeu: 2.433 ± 0.068	0.444TrpMet: 0.444 ± 0.021	0.347TrpAsn: 0.347 ± 0.017	0.714TrpPro: 0.714 ± 0.032	1.055TrpGln: 1.055 ± 0.039	1.06TrpArg: 1.06 ± 0.039	0.775TrpSer: 0.775 ± 0.028	0.605TrpThr: 0.605 ± 0.027	0.893TrpVal: 0.893 ± 0.035	0.316TrpTrp: 0.316 ± 0.019	0.295TrpTyr: 0.295 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.402TyrAla: 2.402 ± 0.051	0.247TyrCys: 0.247 ± 0.014	1.251TyrAsp: 1.251 ± 0.038	1.038TyrGlu: 1.038 ± 0.034	0.892TyrPhe: 0.892 ± 0.034	1.905TyrGly: 1.905 ± 0.046	0.619TyrHis: 0.619 ± 0.024	0.834TyrIle: 0.834 ± 0.033	0.554TyrLys: 0.554 ± 0.023	2.821TyrLeu: 2.821 ± 0.06	0.453TyrMet: 0.453 ± 0.019	0.57TyrAsn: 0.57 ± 0.023	1.234TyrPro: 1.234 ± 0.034	1.152TyrGln: 1.152 ± 0.031	1.914TyrArg: 1.914 ± 0.042	1.336TyrSer: 1.336 ± 0.034	1.161TyrThr: 1.161 ± 0.04	1.516TyrVal: 1.516 ± 0.042	0.321TyrTrp: 0.321 ± 0.017	0.678TyrTyr: 0.678 ± 0.028	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.002XaaAsp: 0.002 ± 0.002	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.001XaaLeu: 0.001 ± 0.001	0.0XaaMet: 0.0 ± 0.0	0.001XaaAsn: 0.001 ± 0.001	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.001XaaSer: 0.001 ± 0.001	0.0XaaThr: 0.0 ± 0.0	0.001XaaVal: 0.001 ± 0.001	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3112 proteins (1036695 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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