Amino acid dipepetide frequency for Tomato leaf curl Liwa virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.272AlaAla: 8.272 ± 2.464
0.919AlaCys: 0.919 ± 0.781
1.838AlaAsp: 1.838 ± 1.161
2.757AlaGlu: 2.757 ± 1.402
0.0AlaPhe: 0.0 ± 0.0
0.919AlaGly: 0.919 ± 0.651
1.838AlaHis: 1.838 ± 1.178
1.838AlaIle: 1.838 ± 0.961
5.515AlaLys: 5.515 ± 1.689
8.272AlaLeu: 8.272 ± 2.222
0.919AlaMet: 0.919 ± 0.987
1.838AlaAsn: 1.838 ± 0.724
2.757AlaPro: 2.757 ± 1.489
4.596AlaGln: 4.596 ± 1.386
4.596AlaArg: 4.596 ± 2.428
6.434AlaSer: 6.434 ± 2.069
4.596AlaThr: 4.596 ± 2.028
2.757AlaVal: 2.757 ± 2.217
0.919AlaTrp: 0.919 ± 0.781
0.0AlaTyr: 0.0 ± 0.0
0.0AlaXaa: 0.0 ± 0.0
Cys
0.0CysAla: 0.0 ± 0.0
1.838CysCys: 1.838 ± 1.994
0.0CysAsp: 0.0 ± 0.0
0.919CysGlu: 0.919 ± 0.781
0.919CysPhe: 0.919 ± 0.987
1.838CysGly: 1.838 ± 0.961
2.757CysHis: 2.757 ± 1.365
0.919CysIle: 0.919 ± 1.029
0.919CysLys: 0.919 ± 0.781
0.0CysLeu: 0.0 ± 0.0
0.919CysMet: 0.919 ± 0.997
1.838CysAsn: 1.838 ± 1.302
1.838CysPro: 1.838 ± 1.994
0.919CysGln: 0.919 ± 0.997
0.0CysArg: 0.0 ± 0.0
1.838CysSer: 1.838 ± 1.822
0.919CysThr: 0.919 ± 0.781
2.757CysVal: 2.757 ± 1.358
0.0CysTrp: 0.0 ± 0.0
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
2.757AspAla: 2.757 ± 1.365
0.919AspCys: 0.919 ± 0.911
2.757AspAsp: 2.757 ± 0.965
2.757AspGlu: 2.757 ± 1.134
1.838AspPhe: 1.838 ± 0.724
2.757AspGly: 2.757 ± 1.953
1.838AspHis: 1.838 ± 1.974
3.676AspIle: 3.676 ± 1.851
0.0AspLys: 0.0 ± 0.0
6.434AspLeu: 6.434 ± 2.178
0.0AspMet: 0.0 ± 0.0
2.757AspAsn: 2.757 ± 1.936
1.838AspPro: 1.838 ± 1.05
0.919AspGln: 0.919 ± 0.651
2.757AspArg: 2.757 ± 1.358
3.676AspSer: 3.676 ± 1.185
1.838AspThr: 1.838 ± 1.178
5.515AspVal: 5.515 ± 1.617
2.757AspTrp: 2.757 ± 1.365
0.919AspTyr: 0.919 ± 0.651
0.0AspXaa: 0.0 ± 0.0
Glu
4.596GluAla: 4.596 ± 1.835
0.919GluCys: 0.919 ± 0.651
0.919GluAsp: 0.919 ± 1.029
4.596GluGlu: 4.596 ± 1.711
2.757GluPhe: 2.757 ± 1.434
3.676GluGly: 3.676 ± 1.155
1.838GluHis: 1.838 ± 1.023
1.838GluIle: 1.838 ± 1.023
3.676GluLys: 3.676 ± 1.911
0.919GluLeu: 0.919 ± 0.651
0.0GluMet: 0.0 ± 0.0
4.596GluAsn: 4.596 ± 2.219
1.838GluPro: 1.838 ± 1.026
2.757GluGln: 2.757 ± 1.818
0.0GluArg: 0.0 ± 0.0
2.757GluSer: 2.757 ± 1.983
0.919GluThr: 0.919 ± 1.029
1.838GluVal: 1.838 ± 0.959
1.838GluTrp: 1.838 ± 0.961
0.0GluTyr: 0.0 ± 0.0
0.0GluXaa: 0.0 ± 0.0
Phe
0.919PheAla: 0.919 ± 0.987
1.838PheCys: 1.838 ± 0.724
2.757PheAsp: 2.757 ± 1.358
0.0PheGlu: 0.0 ± 0.0
1.838PhePhe: 1.838 ± 1.561
0.919PheGly: 0.919 ± 0.781
2.757PheHis: 2.757 ± 0.942
3.676PheIle: 3.676 ± 1.408
4.596PheLys: 4.596 ± 2.891
9.191PheLeu: 9.191 ± 2.319
0.919PheMet: 0.919 ± 0.651
2.757PheAsn: 2.757 ± 0.785
0.919PhePro: 0.919 ± 0.997
4.596PheGln: 4.596 ± 1.625
3.676PheArg: 3.676 ± 1.253
0.919PheSer: 0.919 ± 0.911
1.838PheThr: 1.838 ± 0.961
0.0PheVal: 0.0 ± 0.0
0.0PheTrp: 0.0 ± 0.0
0.919PheTyr: 0.919 ± 0.781
0.0PheXaa: 0.0 ± 0.0
Gly
2.757GlyAla: 2.757 ± 1.953
1.838GlyCys: 1.838 ± 1.161
4.596GlyAsp: 4.596 ± 2.269
0.919GlyGlu: 0.919 ± 0.987
1.838GlyPhe: 1.838 ± 1.178
2.757GlyGly: 2.757 ± 1.134
1.838GlyHis: 1.838 ± 1.023
3.676GlyIle: 3.676 ± 1.47
5.515GlyLys: 5.515 ± 1.617
0.919GlyLeu: 0.919 ± 1.029
2.757GlyMet: 2.757 ± 1.32
0.0GlyAsn: 0.0 ± 0.0
4.596GlyPro: 4.596 ± 1.788
4.596GlyGln: 4.596 ± 1.621
0.919GlyArg: 0.919 ± 0.651
4.596GlySer: 4.596 ± 1.788
2.757GlyThr: 2.757 ± 1.855
1.838GlyVal: 1.838 ± 1.498
0.0GlyTrp: 0.0 ± 0.0
1.838GlyTyr: 1.838 ± 1.178
0.0GlyXaa: 0.0 ± 0.0
His
3.676HisAla: 3.676 ± 1.375
1.838HisCys: 1.838 ± 1.178
0.0HisAsp: 0.0 ± 0.0
0.919HisGlu: 0.919 ± 0.997
3.676HisPhe: 3.676 ± 1.53
1.838HisGly: 1.838 ± 1.178
3.676HisHis: 3.676 ± 2.826
1.838HisIle: 1.838 ± 1.302
2.757HisLys: 2.757 ± 1.318
0.919HisLeu: 0.919 ± 0.651
0.919HisMet: 0.919 ± 0.651
3.676HisAsn: 3.676 ± 2.046
1.838HisPro: 1.838 ± 1.302
0.919HisGln: 0.919 ± 0.781
2.757HisArg: 2.757 ± 1.936
1.838HisSer: 1.838 ± 1.822
2.757HisThr: 2.757 ± 2.342
2.757HisVal: 2.757 ± 1.856
0.919HisTrp: 0.919 ± 0.651
0.919HisTyr: 0.919 ± 0.651
0.0HisXaa: 0.0 ± 0.0
Ile
0.919IleAla: 0.919 ± 0.911
0.919IleCys: 0.919 ± 0.997
2.757IleAsp: 2.757 ± 1.953
1.838IleGlu: 1.838 ± 1.302
3.676IlePhe: 3.676 ± 2.604
0.919IleGly: 0.919 ± 0.781
0.919IleHis: 0.919 ± 0.651
3.676IleIle: 3.676 ± 1.185
4.596IleLys: 4.596 ± 1.252
0.919IleLeu: 0.919 ± 0.651
0.0IleMet: 0.0 ± 0.87
3.676IleAsn: 3.676 ± 1.014
2.757IlePro: 2.757 ± 1.365
0.919IleGln: 0.919 ± 0.651
4.596IleArg: 4.596 ± 1.831
4.596IleSer: 4.596 ± 2.602
7.353IleThr: 7.353 ± 4.147
2.757IleVal: 2.757 ± 1.358
1.838IleTrp: 1.838 ± 1.974
1.838IleTyr: 1.838 ± 1.561
0.0IleXaa: 0.0 ± 0.0
Lys
3.676LysAla: 3.676 ± 1.185
2.757LysCys: 2.757 ± 1.402
1.838LysAsp: 1.838 ± 1.302
3.676LysGlu: 3.676 ± 1.702
1.838LysPhe: 1.838 ± 0.724
5.515LysGly: 5.515 ± 2.158
2.757LysHis: 2.757 ± 1.134
1.838LysIle: 1.838 ± 1.026
2.757LysLys: 2.757 ± 0.965
1.838LysLeu: 1.838 ± 1.302
0.0LysMet: 0.0 ± 0.0
4.596LysAsn: 4.596 ± 2.314
4.596LysPro: 4.596 ± 1.203
0.919LysGln: 0.919 ± 0.781
2.757LysArg: 2.757 ± 2.342
3.676LysSer: 3.676 ± 1.167
1.838LysThr: 1.838 ± 1.023
6.434LysVal: 6.434 ± 1.951
0.0LysTrp: 0.0 ± 0.0
3.676LysTyr: 3.676 ± 0.995
0.0LysXaa: 0.0 ± 0.0
Leu
1.838LeuAla: 1.838 ± 1.178
2.757LeuCys: 2.757 ± 1.276
5.515LeuAsp: 5.515 ± 2.182
3.676LeuGlu: 3.676 ± 1.508
0.0LeuPhe: 0.0 ± 0.0
4.596LeuGly: 4.596 ± 0.899
0.919LeuHis: 0.919 ± 0.651
4.596LeuIle: 4.596 ± 2.215
5.515LeuLys: 5.515 ± 2.184
3.676LeuLeu: 3.676 ± 1.987
0.919LeuMet: 0.919 ± 1.029
3.676LeuAsn: 3.676 ± 0.995
3.676LeuPro: 3.676 ± 1.911
1.838LeuGln: 1.838 ± 1.407
6.434LeuArg: 6.434 ± 2.56
3.676LeuSer: 3.676 ± 2.604
4.596LeuThr: 4.596 ± 1.426
2.757LeuVal: 2.757 ± 1.673
0.919LeuTrp: 0.919 ± 0.987
3.676LeuTyr: 3.676 ± 1.63
0.0LeuXaa: 0.0 ± 0.0
Met
1.838MetAla: 1.838 ± 1.026
0.0MetCys: 0.0 ± 0.0
2.757MetAsp: 2.757 ± 1.533
0.919MetGlu: 0.919 ± 1.029
2.757MetPhe: 2.757 ± 1.756
2.757MetGly: 2.757 ± 1.372
0.919MetHis: 0.919 ± 0.987
0.0MetIle: 0.0 ± 0.0
0.919MetLys: 0.919 ± 0.781
1.838MetLeu: 1.838 ± 1.05
0.919MetMet: 0.919 ± 1.029
0.919MetAsn: 0.919 ± 0.781
0.919MetPro: 0.919 ± 0.651
0.919MetGln: 0.919 ± 1.029
1.838MetArg: 1.838 ± 1.161
3.676MetSer: 3.676 ± 1.855
0.0MetThr: 0.0 ± 0.0
0.0MetVal: 0.0 ± 0.0
1.838MetTrp: 1.838 ± 1.05
1.838MetTyr: 1.838 ± 1.561
0.0MetXaa: 0.0 ± 0.0
Asn
3.676AsnAla: 3.676 ± 1.702
0.0AsnCys: 0.0 ± 0.0
2.757AsnAsp: 2.757 ± 1.134
1.838AsnGlu: 1.838 ± 1.135
2.757AsnPhe: 2.757 ± 0.785
0.919AsnGly: 0.919 ± 0.987
4.596AsnHis: 4.596 ± 2.219
1.838AsnIle: 1.838 ± 0.724
1.838AsnLys: 1.838 ± 0.961
5.515AsnLeu: 5.515 ± 2.36
1.838AsnMet: 1.838 ± 1.468
2.757AsnAsn: 2.757 ± 1.902
3.676AsnPro: 3.676 ± 1.014
3.676AsnGln: 3.676 ± 1.014
5.515AsnArg: 5.515 ± 2.397
6.434AsnSer: 6.434 ± 1.94
1.838AsnThr: 1.838 ± 1.302
4.596AsnVal: 4.596 ± 2.139
0.0AsnTrp: 0.0 ± 0.0
2.757AsnTyr: 2.757 ± 1.434
0.0AsnXaa: 0.0 ± 0.0
Pro
3.676ProAla: 3.676 ± 1.465
1.838ProCys: 1.838 ± 1.135
3.676ProAsp: 3.676 ± 1.253
2.757ProGlu: 2.757 ± 1.855
1.838ProPhe: 1.838 ± 1.023
0.919ProGly: 0.919 ± 0.651
2.757ProHis: 2.757 ± 1.434
3.676ProIle: 3.676 ± 1.375
3.676ProLys: 3.676 ± 2.604
3.676ProLeu: 3.676 ± 1.53
5.515ProMet: 5.515 ± 2.124
4.596ProAsn: 4.596 ± 1.711
1.838ProPro: 1.838 ± 0.959
1.838ProGln: 1.838 ± 1.285
5.515ProArg: 5.515 ± 1.173
6.434ProSer: 6.434 ± 2.987
0.919ProThr: 0.919 ± 1.029
4.596ProVal: 4.596 ± 1.625
0.0ProTrp: 0.0 ± 0.0
2.757ProTyr: 2.757 ± 1.358
0.0ProXaa: 0.0 ± 0.0
Gln
5.515GlnAla: 5.515 ± 1.512
0.0GlnCys: 0.0 ± 0.0
3.676GlnAsp: 3.676 ± 1.283
1.838GlnGlu: 1.838 ± 0.724
2.757GlnPhe: 2.757 ± 1.953
0.919GlnGly: 0.919 ± 0.651
0.919GlnHis: 0.919 ± 0.911
2.757GlnIle: 2.757 ± 1.402
0.919GlnLys: 0.919 ± 0.997
2.757GlnLeu: 2.757 ± 2.366
0.919GlnMet: 0.919 ± 0.911
1.838GlnAsn: 1.838 ± 1.135
3.676GlnPro: 3.676 ± 2.186
4.596GlnGln: 4.596 ± 2.157
2.757GlnArg: 2.757 ± 0.961
5.515GlnSer: 5.515 ± 0.952
2.757GlnThr: 2.757 ± 1.325
6.434GlnVal: 6.434 ± 1.595
0.0GlnTrp: 0.0 ± 0.0
0.919GlnTyr: 0.919 ± 0.651
0.0GlnXaa: 0.0 ± 0.0
Arg
3.676ArgAla: 3.676 ± 1.375
2.757ArgCys: 2.757 ± 1.26
4.596ArgAsp: 4.596 ± 2.028
2.757ArgGlu: 2.757 ± 1.152
3.676ArgPhe: 3.676 ± 2.206
3.676ArgGly: 3.676 ± 1.47
2.757ArgHis: 2.757 ± 1.079
4.596ArgIle: 4.596 ± 1.143
2.757ArgLys: 2.757 ± 1.533
2.757ArgLeu: 2.757 ± 1.26
2.757ArgMet: 2.757 ± 1.373
1.838ArgAsn: 1.838 ± 1.05
7.353ArgPro: 7.353 ± 1.519
1.838ArgGln: 1.838 ± 1.528
6.434ArgArg: 6.434 ± 3.553
4.596ArgSer: 4.596 ± 1.037
2.757ArgThr: 2.757 ± 1.325
4.596ArgVal: 4.596 ± 2.235
0.0ArgTrp: 0.0 ± 0.0
0.919ArgTyr: 0.919 ± 0.997
0.0ArgXaa: 0.0 ± 0.0
Ser
4.596SerAla: 4.596 ± 2.507
0.0SerCys: 0.0 ± 0.0
2.757SerAsp: 2.757 ± 0.965
2.757SerGlu: 2.757 ± 1.372
3.676SerPhe: 3.676 ± 1.305
2.757SerGly: 2.757 ± 1.358
0.919SerHis: 0.919 ± 0.781
4.596SerIle: 4.596 ± 1.648
2.757SerLys: 2.757 ± 1.818
2.757SerLeu: 2.757 ± 1.276
1.838SerMet: 1.838 ± 2.058
5.515SerAsn: 5.515 ± 1.689
9.191SerPro: 9.191 ± 2.39
4.596SerGln: 4.596 ± 1.793
7.353SerArg: 7.353 ± 1.78
15.625SerSer: 15.625 ± 4.64
5.515SerThr: 5.515 ± 3.429
4.596SerVal: 4.596 ± 1.664
0.0SerTrp: 0.0 ± 0.0
6.434SerTyr: 6.434 ± 1.088
0.0SerXaa: 0.0 ± 0.0
Thr
3.676ThrAla: 3.676 ± 0.933
0.0ThrCys: 0.0 ± 0.0
0.0ThrAsp: 0.0 ± 0.0
1.838ThrGlu: 1.838 ± 1.026
0.919ThrPhe: 0.919 ± 0.651
5.515ThrGly: 5.515 ± 1.725
4.596ThrHis: 4.596 ± 2.034
0.0ThrIle: 0.0 ± 0.0
1.838ThrLys: 1.838 ± 0.724
4.596ThrLeu: 4.596 ± 1.373
0.919ThrMet: 0.919 ± 0.651
1.838ThrAsn: 1.838 ± 1.026
5.515ThrPro: 5.515 ± 3.048
3.676ThrGln: 3.676 ± 1.417
1.838ThrArg: 1.838 ± 1.161
3.676ThrSer: 3.676 ± 3.372
0.919ThrThr: 0.919 ± 0.987
4.596ThrVal: 4.596 ± 1.956
0.0ThrTrp: 0.0 ± 0.0
2.757ThrTyr: 2.757 ± 0.785
0.0ThrXaa: 0.0 ± 0.0
Val
0.0ValAla: 0.0 ± 0.0
0.0ValCys: 0.0 ± 0.0
2.757ValAsp: 2.757 ± 1.18
2.757ValGlu: 2.757 ± 1.941
4.596ValPhe: 4.596 ± 2.84
3.676ValGly: 3.676 ± 1.167
0.919ValHis: 0.919 ± 0.997
5.515ValIle: 5.515 ± 1.19
5.515ValLys: 5.515 ± 2.145
2.757ValLeu: 2.757 ± 2.961
1.838ValMet: 1.838 ± 1.561
5.515ValAsn: 5.515 ± 2.323
2.757ValPro: 2.757 ± 0.965
6.434ValGln: 6.434 ± 1.943
3.676ValArg: 3.676 ± 3.122
3.676ValSer: 3.676 ± 1.465
3.676ValThr: 3.676 ± 2.093
1.838ValVal: 1.838 ± 1.023
0.919ValTrp: 0.919 ± 0.781
4.596ValTyr: 4.596 ± 0.975
0.0ValXaa: 0.0 ± 0.0
Trp
3.676TrpAla: 3.676 ± 1.702
0.0TrpCys: 0.0 ± 0.0
0.919TrpAsp: 0.919 ± 0.997
0.919TrpGlu: 0.919 ± 0.987
0.0TrpPhe: 0.0 ± 0.0
0.919TrpGly: 0.919 ± 0.651
0.0TrpHis: 0.0 ± 0.0
0.0TrpIle: 0.0 ± 0.0
0.0TrpLys: 0.0 ± 0.0
0.0TrpLeu: 0.0 ± 0.0
0.919TrpMet: 0.919 ± 0.781
0.919TrpAsn: 0.919 ± 0.987
0.0TrpPro: 0.0 ± 0.0
0.919TrpGln: 0.919 ± 0.651
0.919TrpArg: 0.919 ± 0.911
0.919TrpSer: 0.919 ± 0.911
0.919TrpThr: 0.919 ± 0.987
0.0TrpVal: 0.0 ± 0.0
0.0TrpTrp: 0.0 ± 0.0
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.838TyrAla: 1.838 ± 1.561
0.0TyrCys: 0.0 ± 0.0
1.838TyrAsp: 1.838 ± 1.135
1.838TyrGlu: 1.838 ± 1.561
3.676TyrPhe: 3.676 ± 1.686
2.757TyrGly: 2.757 ± 0.965
0.919TyrHis: 0.919 ± 0.651
1.838TyrIle: 1.838 ± 1.302
0.919TyrLys: 0.919 ± 0.651
5.515TyrLeu: 5.515 ± 2.362
1.838TyrMet: 1.838 ± 0.967
3.676TyrAsn: 3.676 ± 0.995
0.919TyrPro: 0.919 ± 0.651
0.0TyrGln: 0.0 ± 0.0
2.757TyrArg: 2.757 ± 1.533
3.676TyrSer: 3.676 ± 1.53
0.0TyrThr: 0.0 ± 0.0
2.757TyrVal: 2.757 ± 1.318
0.0TyrTrp: 0.0 ± 0.0
0.0TyrTyr: 0.0 ± 0.0
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 6 proteins (1089 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski