Amino acid dipepetide frequency for SAR202 cluster bacterium AD-802-K11_MRT_200m

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.551AlaAla: 6.551 ± 0.249
0.686AlaCys: 0.686 ± 0.057
3.886AlaAsp: 3.886 ± 0.112
4.664AlaGlu: 4.664 ± 0.144
3.008AlaPhe: 3.008 ± 0.124
6.152AlaGly: 6.152 ± 0.161
1.488AlaHis: 1.488 ± 0.07
5.685AlaIle: 5.685 ± 0.183
3.236AlaLys: 3.236 ± 0.12
7.425AlaLeu: 7.425 ± 0.193
2.099AlaMet: 2.099 ± 0.098
2.486AlaAsn: 2.486 ± 0.108
2.713AlaPro: 2.713 ± 0.105
1.915AlaGln: 1.915 ± 0.083
3.467AlaArg: 3.467 ± 0.128
5.65AlaSer: 5.65 ± 0.144
4.058AlaThr: 4.058 ± 0.126
5.873AlaVal: 5.873 ± 0.184
0.778AlaTrp: 0.778 ± 0.061
2.083AlaTyr: 2.083 ± 0.093
0.0AlaXaa: 0.0 ± 0.0
Cys
0.634CysAla: 0.634 ± 0.054
0.116CysCys: 0.116 ± 0.024
0.598CysAsp: 0.598 ± 0.054
0.563CysGlu: 0.563 ± 0.049
0.387CysPhe: 0.387 ± 0.037
0.974CysGly: 0.974 ± 0.068
0.267CysHis: 0.267 ± 0.039
0.511CysIle: 0.511 ± 0.047
0.383CysLys: 0.383 ± 0.037
0.862CysLeu: 0.862 ± 0.058
0.219CysMet: 0.219 ± 0.026
0.323CysAsn: 0.323 ± 0.036
0.515CysPro: 0.515 ± 0.059
0.259CysGln: 0.259 ± 0.035
0.487CysArg: 0.487 ± 0.041
0.67CysSer: 0.67 ± 0.055
0.387CysThr: 0.387 ± 0.039
0.59CysVal: 0.59 ± 0.048
0.108CysTrp: 0.108 ± 0.025
0.263CysTyr: 0.263 ± 0.034
0.0CysXaa: 0.0 ± 0.0
Asp
3.762AspAla: 3.762 ± 0.157
0.531AspCys: 0.531 ± 0.052
3.16AspAsp: 3.16 ± 0.124
4.189AspGlu: 4.189 ± 0.142
2.502AspPhe: 2.502 ± 0.096
4.7AspGly: 4.7 ± 0.187
1.412AspHis: 1.412 ± 0.066
4.672AspIle: 4.672 ± 0.122
2.494AspLys: 2.494 ± 0.088
5.809AspLeu: 5.809 ± 0.17
1.779AspMet: 1.779 ± 0.073
2.17AspAsn: 2.17 ± 0.108
2.921AspPro: 2.921 ± 0.108
1.803AspGln: 1.803 ± 0.088
3.244AspArg: 3.244 ± 0.125
4.237AspSer: 4.237 ± 0.136
2.753AspThr: 2.753 ± 0.103
4.5AspVal: 4.5 ± 0.164
0.83AspTrp: 0.83 ± 0.062
2.031AspTyr: 2.031 ± 0.091
0.0AspXaa: 0.0 ± 0.0
Glu
5.111GluAla: 5.111 ± 0.157
0.507GluCys: 0.507 ± 0.044
3.926GluAsp: 3.926 ± 0.14
5.131GluGlu: 5.131 ± 0.187
2.334GluPhe: 2.334 ± 0.097
5.155GluGly: 5.155 ± 0.173
1.361GluHis: 1.361 ± 0.074
5.462GluIle: 5.462 ± 0.169
3.451GluLys: 3.451 ± 0.124
6.076GluLeu: 6.076 ± 0.172
1.843GluMet: 1.843 ± 0.086
3.323GluAsn: 3.323 ± 0.135
2.111GluPro: 2.111 ± 0.093
1.863GluGln: 1.863 ± 0.101
3.475GluArg: 3.475 ± 0.129
4.868GluSer: 4.868 ± 0.149
3.754GluThr: 3.754 ± 0.13
4.78GluVal: 4.78 ± 0.153
0.966GluTrp: 0.966 ± 0.065
2.214GluTyr: 2.214 ± 0.094
0.0GluXaa: 0.0 ± 0.0
Phe
2.873PheAla: 2.873 ± 0.116
0.575PheCys: 0.575 ± 0.052
2.865PheAsp: 2.865 ± 0.11
2.625PheGlu: 2.625 ± 0.097
1.584PhePhe: 1.584 ± 0.098
3.519PheGly: 3.519 ± 0.135
0.866PheHis: 0.866 ± 0.054
2.565PheIle: 2.565 ± 0.113
1.396PheLys: 1.396 ± 0.073
3.527PheLeu: 3.527 ± 0.142
1.041PheMet: 1.041 ± 0.062
1.616PheAsn: 1.616 ± 0.078
1.66PhePro: 1.66 ± 0.089
1.189PheGln: 1.189 ± 0.066
2.003PheArg: 2.003 ± 0.096
3.012PheSer: 3.012 ± 0.118
2.087PheThr: 2.087 ± 0.099
2.865PheVal: 2.865 ± 0.109
0.598PheTrp: 0.598 ± 0.055
1.033PheTyr: 1.033 ± 0.064
0.0PheXaa: 0.0 ± 0.0
Gly
6.084GlyAla: 6.084 ± 0.174
0.762GlyCys: 0.762 ± 0.068
4.572GlyAsp: 4.572 ± 0.16
5.079GlyGlu: 5.079 ± 0.157
3.595GlyPhe: 3.595 ± 0.119
6.699GlyGly: 6.699 ± 0.193
1.855GlyHis: 1.855 ± 0.086
6.559GlyIle: 6.559 ± 0.184
4.137GlyLys: 4.137 ± 0.153
7.154GlyLeu: 7.154 ± 0.188
2.394GlyMet: 2.394 ± 0.1
3.256GlyAsn: 3.256 ± 0.111
3.132GlyPro: 3.132 ± 0.12
2.442GlyGln: 2.442 ± 0.108
4.205GlyArg: 4.205 ± 0.137
6.12GlySer: 6.12 ± 0.153
4.852GlyThr: 4.852 ± 0.142
6.316GlyVal: 6.316 ± 0.171
1.388GlyTrp: 1.388 ± 0.076
2.641GlyTyr: 2.641 ± 0.097
0.0GlyXaa: 0.0 ± 0.0
His
1.197HisAla: 1.197 ± 0.065
0.211HisCys: 0.211 ± 0.025
1.045HisAsp: 1.045 ± 0.066
1.137HisGlu: 1.137 ± 0.059
0.882HisPhe: 0.882 ± 0.056
1.787HisGly: 1.787 ± 0.098
0.594HisHis: 0.594 ± 0.051
1.484HisIle: 1.484 ± 0.087
0.762HisLys: 0.762 ± 0.054
1.903HisLeu: 1.903 ± 0.082
0.559HisMet: 0.559 ± 0.044
0.782HisAsn: 0.782 ± 0.056
1.512HisPro: 1.512 ± 0.079
0.67HisGln: 0.67 ± 0.058
1.013HisArg: 1.013 ± 0.063
1.54HisSer: 1.54 ± 0.087
1.169HisThr: 1.169 ± 0.073
1.408HisVal: 1.408 ± 0.083
0.339HisTrp: 0.339 ± 0.039
0.586HisTyr: 0.586 ± 0.049
0.0HisXaa: 0.0 ± 0.0
Ile
6.045IleAla: 6.045 ± 0.165
0.742IleCys: 0.742 ± 0.055
4.716IleAsp: 4.716 ± 0.147
4.939IleGlu: 4.939 ± 0.155
2.769IlePhe: 2.769 ± 0.12
6.049IleGly: 6.049 ± 0.171
1.468IleHis: 1.468 ± 0.079
4.121IleIle: 4.121 ± 0.155
3.032IleLys: 3.032 ± 0.123
6.432IleLeu: 6.432 ± 0.172
1.54IleMet: 1.54 ± 0.075
2.936IleAsn: 2.936 ± 0.108
3.85IlePro: 3.85 ± 0.127
2.075IleGln: 2.075 ± 0.084
3.511IleArg: 3.511 ± 0.124
6.216IleSer: 6.216 ± 0.179
3.95IleThr: 3.95 ± 0.147
5.243IleVal: 5.243 ± 0.152
1.005IleTrp: 1.005 ± 0.068
1.795IleTyr: 1.795 ± 0.082
0.0IleXaa: 0.0 ± 0.0
Lys
3.124LysAla: 3.124 ± 0.104
0.371LysCys: 0.371 ± 0.038
2.641LysAsp: 2.641 ± 0.112
3.224LysGlu: 3.224 ± 0.113
1.544LysPhe: 1.544 ± 0.088
3.371LysGly: 3.371 ± 0.111
0.738LysHis: 0.738 ± 0.063
3.539LysIle: 3.539 ± 0.138
2.33LysLys: 2.33 ± 0.108
3.926LysLeu: 3.926 ± 0.127
1.345LysMet: 1.345 ± 0.068
2.286LysAsn: 2.286 ± 0.095
1.807LysPro: 1.807 ± 0.095
1.121LysGln: 1.121 ± 0.073
2.226LysArg: 2.226 ± 0.1
3.471LysSer: 3.471 ± 0.128
2.53LysThr: 2.53 ± 0.096
3.451LysVal: 3.451 ± 0.131
0.638LysTrp: 0.638 ± 0.057
1.233LysTyr: 1.233 ± 0.066
0.0LysXaa: 0.0 ± 0.0
Leu
7.465LeuAla: 7.465 ± 0.171
0.886LeuCys: 0.886 ± 0.06
6.013LeuAsp: 6.013 ± 0.172
6.364LeuGlu: 6.364 ± 0.168
3.443LeuPhe: 3.443 ± 0.126
7.892LeuGly: 7.892 ± 0.169
1.6LeuHis: 1.6 ± 0.077
6.348LeuIle: 6.348 ± 0.212
4.157LeuLys: 4.157 ± 0.125
7.549LeuLeu: 7.549 ± 0.215
2.374LeuMet: 2.374 ± 0.111
3.659LeuAsn: 3.659 ± 0.126
3.858LeuPro: 3.858 ± 0.12
2.494LeuGln: 2.494 ± 0.112
4.564LeuArg: 4.564 ± 0.143
7.297LeuSer: 7.297 ± 0.219
4.748LeuThr: 4.748 ± 0.145
6.38LeuVal: 6.38 ± 0.161
1.057LeuTrp: 1.057 ± 0.077
2.127LeuTyr: 2.127 ± 0.088
0.0LeuXaa: 0.0 ± 0.0
Met
2.402MetAla: 2.402 ± 0.093
0.211MetCys: 0.211 ± 0.031
1.548MetAsp: 1.548 ± 0.083
1.684MetGlu: 1.684 ± 0.098
0.898MetPhe: 0.898 ± 0.066
2.577MetGly: 2.577 ± 0.105
0.415MetHis: 0.415 ± 0.044
1.568MetIle: 1.568 ± 0.081
1.349MetLys: 1.349 ± 0.074
2.127MetLeu: 2.127 ± 0.089
0.77MetMet: 0.77 ± 0.062
1.137MetAsn: 1.137 ± 0.07
1.325MetPro: 1.325 ± 0.079
0.658MetGln: 0.658 ± 0.049
1.468MetArg: 1.468 ± 0.077
2.143MetSer: 2.143 ± 0.083
1.831MetThr: 1.831 ± 0.079
1.955MetVal: 1.955 ± 0.082
0.291MetTrp: 0.291 ± 0.043
0.59MetTyr: 0.59 ± 0.054
0.0MetXaa: 0.0 ± 0.0
Asn
2.873AsnAla: 2.873 ± 0.111
0.435AsnCys: 0.435 ± 0.04
1.979AsnAsp: 1.979 ± 0.104
2.33AsnGlu: 2.33 ± 0.098
1.636AsnPhe: 1.636 ± 0.079
2.909AsnGly: 2.909 ± 0.108
0.834AsnHis: 0.834 ± 0.054
3.24AsnIle: 3.24 ± 0.121
1.795AsnLys: 1.795 ± 0.082
3.978AsnLeu: 3.978 ± 0.119
1.121AsnMet: 1.121 ± 0.062
1.676AsnAsn: 1.676 ± 0.086
2.538AsnPro: 2.538 ± 0.107
1.317AsnGln: 1.317 ± 0.069
2.258AsnArg: 2.258 ± 0.099
2.769AsnSer: 2.769 ± 0.117
2.222AsnThr: 2.222 ± 0.099
2.901AsnVal: 2.901 ± 0.121
0.523AsnTrp: 0.523 ± 0.044
1.193AsnTyr: 1.193 ± 0.073
0.0AsnXaa: 0.0 ± 0.0
Pro
2.629ProAla: 2.629 ± 0.11
0.283ProCys: 0.283 ± 0.038
3.172ProAsp: 3.172 ± 0.116
3.431ProGlu: 3.431 ± 0.131
1.716ProPhe: 1.716 ± 0.077
3.778ProGly: 3.778 ± 0.136
1.089ProHis: 1.089 ± 0.067
3.232ProIle: 3.232 ± 0.126
1.911ProLys: 1.911 ± 0.104
3.587ProLeu: 3.587 ± 0.108
1.157ProMet: 1.157 ± 0.059
1.975ProAsn: 1.975 ± 0.089
1.783ProPro: 1.783 ± 0.087
1.261ProGln: 1.261 ± 0.074
1.995ProArg: 1.995 ± 0.088
3.431ProSer: 3.431 ± 0.114
2.633ProThr: 2.633 ± 0.131
3.615ProVal: 3.615 ± 0.123
0.579ProTrp: 0.579 ± 0.053
1.424ProTyr: 1.424 ± 0.077
0.0ProXaa: 0.0 ± 0.0
Gln
2.079GlnAla: 2.079 ± 0.113
0.327GlnCys: 0.327 ± 0.041
1.532GlnAsp: 1.532 ± 0.073
2.111GlnGlu: 2.111 ± 0.074
1.117GlnPhe: 1.117 ± 0.068
2.131GlnGly: 2.131 ± 0.102
0.495GlnHis: 0.495 ± 0.042
2.386GlnIle: 2.386 ± 0.09
1.568GlnLys: 1.568 ± 0.075
2.661GlnLeu: 2.661 ± 0.102
0.854GlnMet: 0.854 ± 0.054
1.333GlnAsn: 1.333 ± 0.077
1.105GlnPro: 1.105 ± 0.071
0.874GlnGln: 0.874 ± 0.062
1.676GlnArg: 1.676 ± 0.091
2.115GlnSer: 2.115 ± 0.094
1.576GlnThr: 1.576 ± 0.08
2.103GlnVal: 2.103 ± 0.08
0.383GlnTrp: 0.383 ± 0.041
0.762GlnTyr: 0.762 ± 0.05
0.0GlnXaa: 0.0 ± 0.0
Arg
3.268ArgAla: 3.268 ± 0.129
0.439ArgCys: 0.439 ± 0.047
3.128ArgAsp: 3.128 ± 0.108
3.575ArgGlu: 3.575 ± 0.142
2.139ArgPhe: 2.139 ± 0.092
3.798ArgGly: 3.798 ± 0.142
0.977ArgHis: 0.977 ± 0.055
3.894ArgIle: 3.894 ± 0.132
2.438ArgLys: 2.438 ± 0.097
4.592ArgLeu: 4.592 ± 0.141
1.46ArgMet: 1.46 ± 0.076
2.158ArgAsn: 2.158 ± 0.085
2.25ArgPro: 2.25 ± 0.096
1.732ArgGln: 1.732 ± 0.085
2.96ArgArg: 2.96 ± 0.15
3.699ArgSer: 3.699 ± 0.132
2.545ArgThr: 2.545 ± 0.108
3.85ArgVal: 3.85 ± 0.137
0.67ArgTrp: 0.67 ± 0.059
1.724ArgTyr: 1.724 ± 0.075
0.0ArgXaa: 0.0 ± 0.0
Ser
5.051SerAla: 5.051 ± 0.178
0.543SerCys: 0.543 ± 0.048
4.6SerAsp: 4.6 ± 0.126
5.326SerGlu: 5.326 ± 0.167
3.14SerPhe: 3.14 ± 0.117
6.703SerGly: 6.703 ± 0.165
1.516SerHis: 1.516 ± 0.082
5.358SerIle: 5.358 ± 0.164
3.216SerLys: 3.216 ± 0.116
6.87SerLeu: 6.87 ± 0.201
2.111SerMet: 2.111 ± 0.092
3.104SerAsn: 3.104 ± 0.118
3.495SerPro: 3.495 ± 0.127
2.462SerGln: 2.462 ± 0.109
4.022SerArg: 4.022 ± 0.136
5.602SerSer: 5.602 ± 0.169
3.77SerThr: 3.77 ± 0.117
5.769SerVal: 5.769 ± 0.154
0.993SerTrp: 0.993 ± 0.074
1.987SerTyr: 1.987 ± 0.087
0.0SerXaa: 0.0 ± 0.0
Thr
3.934ThrAla: 3.934 ± 0.129
0.359ThrCys: 0.359 ± 0.034
3.144ThrAsp: 3.144 ± 0.114
3.455ThrGlu: 3.455 ± 0.107
2.166ThrPhe: 2.166 ± 0.098
5.211ThrGly: 5.211 ± 0.163
1.233ThrHis: 1.233 ± 0.065
3.575ThrIle: 3.575 ± 0.123
2.366ThrLys: 2.366 ± 0.093
5.215ThrLeu: 5.215 ± 0.145
1.329ThrMet: 1.329 ± 0.08
2.039ThrAsn: 2.039 ± 0.098
2.921ThrPro: 2.921 ± 0.137
1.528ThrGln: 1.528 ± 0.086
2.665ThrArg: 2.665 ± 0.107
4.078ThrSer: 4.078 ± 0.137
3.124ThrThr: 3.124 ± 0.124
4.325ThrVal: 4.325 ± 0.137
0.583ThrTrp: 0.583 ± 0.047
1.54ThrTyr: 1.54 ± 0.076
0.0ThrXaa: 0.0 ± 0.0
Val
6.092ValAla: 6.092 ± 0.163
0.722ValCys: 0.722 ± 0.059
4.564ValAsp: 4.564 ± 0.153
5.031ValGlu: 5.031 ± 0.145
2.829ValPhe: 2.829 ± 0.116
5.897ValGly: 5.897 ± 0.167
1.293ValHis: 1.293 ± 0.074
5.478ValIle: 5.478 ± 0.145
3.18ValLys: 3.18 ± 0.119
6.607ValLeu: 6.607 ± 0.189
1.855ValMet: 1.855 ± 0.084
2.909ValAsn: 2.909 ± 0.114
3.32ValPro: 3.32 ± 0.112
2.135ValGln: 2.135 ± 0.088
3.818ValArg: 3.818 ± 0.126
5.634ValSer: 5.634 ± 0.136
4.612ValThr: 4.612 ± 0.136
5.598ValVal: 5.598 ± 0.161
0.802ValTrp: 0.802 ± 0.064
1.951ValTyr: 1.951 ± 0.094
0.0ValXaa: 0.0 ± 0.0
Trp
0.878TrpAla: 0.878 ± 0.062
0.104TrpCys: 0.104 ± 0.019
0.854TrpAsp: 0.854 ± 0.067
0.834TrpGlu: 0.834 ± 0.065
0.61TrpPhe: 0.61 ± 0.055
1.193TrpGly: 1.193 ± 0.086
0.379TrpHis: 0.379 ± 0.038
0.981TrpIle: 0.981 ± 0.071
0.622TrpLys: 0.622 ± 0.053
1.237TrpLeu: 1.237 ± 0.079
0.355TrpMet: 0.355 ± 0.031
0.495TrpAsn: 0.495 ± 0.042
0.519TrpPro: 0.519 ± 0.044
0.471TrpGln: 0.471 ± 0.045
0.634TrpArg: 0.634 ± 0.053
0.918TrpSer: 0.918 ± 0.067
0.69TrpThr: 0.69 ± 0.058
0.79TrpVal: 0.79 ± 0.063
0.227TrpTrp: 0.227 ± 0.036
0.339TrpTyr: 0.339 ± 0.038
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.851TyrAla: 1.851 ± 0.08
0.307TyrCys: 0.307 ± 0.032
1.556TyrAsp: 1.556 ± 0.083
2.019TyrGlu: 2.019 ± 0.087
1.201TyrPhe: 1.201 ± 0.068
2.749TyrGly: 2.749 ± 0.101
0.702TyrHis: 0.702 ± 0.054
1.775TyrIle: 1.775 ± 0.091
1.097TyrLys: 1.097 ± 0.059
2.737TyrLeu: 2.737 ± 0.114
0.738TyrMet: 0.738 ± 0.051
0.862TyrAsn: 0.862 ± 0.057
1.349TyrPro: 1.349 ± 0.085
0.918TyrGln: 0.918 ± 0.063
1.604TyrArg: 1.604 ± 0.086
2.17TyrSer: 2.17 ± 0.094
1.496TyrThr: 1.496 ± 0.074
2.015TyrVal: 2.015 ± 0.086
0.371TyrTrp: 0.371 ± 0.038
0.786TyrTyr: 0.786 ± 0.061
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 855 proteins (250641 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski