Amino acid dipepetide frequency for Ignicoccus hospitalis (strain KIN4/I / DSM 18386 / JCM 14125)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.886AlaAla: 7.886 ± 0.184
0.872AlaCys: 0.872 ± 0.055
3.009AlaAsp: 3.009 ± 0.081
6.315AlaGlu: 6.315 ± 0.15
3.844AlaPhe: 3.844 ± 0.115
5.179AlaGly: 5.179 ± 0.131
1.323AlaHis: 1.323 ± 0.055
4.275AlaIle: 4.275 ± 0.108
6.061AlaLys: 6.061 ± 0.114
13.01AlaLeu: 13.01 ± 0.24
1.802AlaMet: 1.802 ± 0.062
1.711AlaAsn: 1.711 ± 0.067
3.398AlaPro: 3.398 ± 0.093
1.493AlaGln: 1.493 ± 0.067
5.037AlaArg: 5.037 ± 0.126
5.144AlaSer: 5.144 ± 0.125
3.508AlaThr: 3.508 ± 0.095
7.748AlaVal: 7.748 ± 0.161
1.193AlaTrp: 1.193 ± 0.05
3.082AlaTyr: 3.082 ± 0.095
0.0AlaXaa: 0.0 ± 0.0
Cys
0.729CysAla: 0.729 ± 0.047
0.168CysCys: 0.168 ± 0.022
0.516CysAsp: 0.516 ± 0.038
0.94CysGlu: 0.94 ± 0.062
0.326CysPhe: 0.326 ± 0.03
1.125CysGly: 1.125 ± 0.063
0.248CysHis: 0.248 ± 0.043
0.298CysIle: 0.298 ± 0.03
0.747CysLys: 0.747 ± 0.049
0.777CysLeu: 0.777 ± 0.048
0.183CysMet: 0.183 ± 0.021
0.321CysAsn: 0.321 ± 0.027
1.067CysPro: 1.067 ± 0.064
0.13CysGln: 0.13 ± 0.019
0.428CysArg: 0.428 ± 0.031
0.654CysSer: 0.654 ± 0.041
0.428CysThr: 0.428 ± 0.036
0.712CysVal: 0.712 ± 0.047
0.18CysTrp: 0.18 ± 0.023
0.343CysTyr: 0.343 ± 0.029
0.0CysXaa: 0.0 ± 0.0
Asp
3.528AspAla: 3.528 ± 0.11
0.408AspCys: 0.408 ± 0.029
1.834AspAsp: 1.834 ± 0.068
4.112AspGlu: 4.112 ± 0.115
1.787AspPhe: 1.787 ± 0.07
3.08AspGly: 3.08 ± 0.144
0.657AspHis: 0.657 ± 0.041
1.992AspIle: 1.992 ± 0.073
2.919AspLys: 2.919 ± 0.108
5.094AspLeu: 5.094 ± 0.114
0.925AspMet: 0.925 ± 0.051
0.897AspAsn: 0.897 ± 0.044
3.278AspPro: 3.278 ± 0.104
0.606AspGln: 0.606 ± 0.038
1.654AspArg: 1.654 ± 0.062
1.917AspSer: 1.917 ± 0.069
1.521AspThr: 1.521 ± 0.092
5.42AspVal: 5.42 ± 0.121
0.677AspTrp: 0.677 ± 0.05
1.977AspTyr: 1.977 ± 0.097
0.0AspXaa: 0.0 ± 0.0
Glu
8.47GluAla: 8.47 ± 0.135
0.749GluCys: 0.749 ± 0.046
3.774GluAsp: 3.774 ± 0.107
10.281GluGlu: 10.281 ± 0.216
2.538GluPhe: 2.538 ± 0.082
7.144GluGly: 7.144 ± 0.138
1.012GluHis: 1.012 ± 0.052
4.044GluIle: 4.044 ± 0.118
5.402GluLys: 5.402 ± 0.15
10.306GluLeu: 10.306 ± 0.149
1.879GluMet: 1.879 ± 0.072
1.934GluAsn: 1.934 ± 0.077
3.18GluPro: 3.18 ± 0.1
1.088GluGln: 1.088 ± 0.054
6.094GluArg: 6.094 ± 0.132
2.879GluSer: 2.879 ± 0.088
2.629GluThr: 2.629 ± 0.081
9.948GluVal: 9.948 ± 0.188
1.067GluTrp: 1.067 ± 0.059
2.571GluTyr: 2.571 ± 0.078
0.0GluXaa: 0.0 ± 0.0
Phe
2.744PheAla: 2.744 ± 0.083
0.363PheCys: 0.363 ± 0.028
1.897PheAsp: 1.897 ± 0.069
2.967PheGlu: 2.967 ± 0.089
1.303PhePhe: 1.303 ± 0.062
2.659PheGly: 2.659 ± 0.076
0.609PheHis: 0.609 ± 0.038
1.541PheIle: 1.541 ± 0.058
2.606PheLys: 2.606 ± 0.072
3.709PheLeu: 3.709 ± 0.106
0.819PheMet: 0.819 ± 0.044
1.183PheAsn: 1.183 ± 0.054
1.581PhePro: 1.581 ± 0.071
0.629PheGln: 0.629 ± 0.037
1.556PheArg: 1.556 ± 0.066
2.25PheSer: 2.25 ± 0.081
1.536PheThr: 1.536 ± 0.068
3.583PheVal: 3.583 ± 0.103
0.526PheTrp: 0.526 ± 0.041
1.438PheTyr: 1.438 ± 0.063
0.0PheXaa: 0.0 ± 0.0
Gly
5.996GlyAla: 5.996 ± 0.15
0.932GlyCys: 0.932 ± 0.048
3.538GlyAsp: 3.538 ± 0.096
6.129GlyGlu: 6.129 ± 0.139
2.829GlyPhe: 2.829 ± 0.08
5.545GlyGly: 5.545 ± 0.145
1.082GlyHis: 1.082 ± 0.055
3.904GlyIle: 3.904 ± 0.111
5.738GlyLys: 5.738 ± 0.122
7.613GlyLeu: 7.613 ± 0.135
1.684GlyMet: 1.684 ± 0.067
1.837GlyAsn: 1.837 ± 0.075
3.187GlyPro: 3.187 ± 0.09
0.987GlyGln: 0.987 ± 0.055
4.365GlyArg: 4.365 ± 0.112
4.25GlySer: 4.25 ± 0.107
3.353GlyThr: 3.353 ± 0.088
6.68GlyVal: 6.68 ± 0.148
1.195GlyTrp: 1.195 ± 0.06
2.827GlyTyr: 2.827 ± 0.092
0.0GlyXaa: 0.0 ± 0.0
His
1.253HisAla: 1.253 ± 0.06
0.185HisCys: 0.185 ± 0.022
0.569HisAsp: 0.569 ± 0.04
1.05HisGlu: 1.05 ± 0.052
0.501HisPhe: 0.501 ± 0.031
1.213HisGly: 1.213 ± 0.058
0.336HisHis: 0.336 ± 0.028
0.606HisIle: 0.606 ± 0.044
0.877HisLys: 0.877 ± 0.049
1.549HisLeu: 1.549 ± 0.063
0.321HisMet: 0.321 ± 0.032
0.378HisAsn: 0.378 ± 0.034
1.098HisPro: 1.098 ± 0.054
0.258HisGln: 0.258 ± 0.026
0.581HisArg: 0.581 ± 0.042
0.762HisSer: 0.762 ± 0.046
0.694HisThr: 0.694 ± 0.047
1.431HisVal: 1.431 ± 0.058
0.246HisTrp: 0.246 ± 0.03
0.644HisTyr: 0.644 ± 0.04
0.0HisXaa: 0.0 ± 0.0
Ile
4.38IleAla: 4.38 ± 0.114
0.323IleCys: 0.323 ± 0.027
2.566IleAsp: 2.566 ± 0.081
4.187IleGlu: 4.187 ± 0.119
1.383IlePhe: 1.383 ± 0.065
3.065IleGly: 3.065 ± 0.081
0.714IleHis: 0.714 ± 0.04
3.546IleIle: 3.546 ± 0.11
4.155IleLys: 4.155 ± 0.117
4.145IleLeu: 4.145 ± 0.114
1.368IleMet: 1.368 ± 0.069
1.729IleAsn: 1.729 ± 0.071
2.193IlePro: 2.193 ± 0.074
0.606IleGln: 0.606 ± 0.038
2.912IleArg: 2.912 ± 0.101
2.736IleSer: 2.736 ± 0.096
2.553IleThr: 2.553 ± 0.093
4.458IleVal: 4.458 ± 0.114
0.423IleTrp: 0.423 ± 0.032
1.764IleTyr: 1.764 ± 0.071
0.0IleXaa: 0.0 ± 0.0
Lys
6.154LysAla: 6.154 ± 0.141
0.822LysCys: 0.822 ± 0.053
3.483LysAsp: 3.483 ± 0.103
7.665LysGlu: 7.665 ± 0.164
2.25LysPhe: 2.25 ± 0.068
6.099LysGly: 6.099 ± 0.137
0.905LysHis: 0.905 ± 0.038
3.378LysIle: 3.378 ± 0.096
5.465LysLys: 5.465 ± 0.143
7.422LysLeu: 7.422 ± 0.163
1.541LysMet: 1.541 ± 0.063
1.754LysAsn: 1.754 ± 0.082
3.004LysPro: 3.004 ± 0.095
0.802LysGln: 0.802 ± 0.045
5.059LysArg: 5.059 ± 0.11
2.992LysSer: 2.992 ± 0.096
2.666LysThr: 2.666 ± 0.088
8.592LysVal: 8.592 ± 0.171
0.88LysTrp: 0.88 ± 0.056
2.889LysTyr: 2.889 ± 0.086
0.0LysXaa: 0.0 ± 0.0
Leu
10.316LeuAla: 10.316 ± 0.218
0.922LeuCys: 0.922 ± 0.057
4.766LeuAsp: 4.766 ± 0.126
9.64LeuGlu: 9.64 ± 0.192
3.227LeuPhe: 3.227 ± 0.099
8.502LeuGly: 8.502 ± 0.157
1.551LeuHis: 1.551 ± 0.063
5.252LeuIle: 5.252 ± 0.128
9.464LeuLys: 9.464 ± 0.177
11.083LeuLeu: 11.083 ± 0.251
2.37LeuMet: 2.37 ± 0.081
3.265LeuAsn: 3.265 ± 0.109
5.187LeuPro: 5.187 ± 0.117
1.762LeuGln: 1.762 ± 0.077
6.898LeuArg: 6.898 ± 0.155
6.753LeuSer: 6.753 ± 0.157
5.029LeuThr: 5.029 ± 0.202
9.141LeuVal: 9.141 ± 0.163
1.328LeuTrp: 1.328 ± 0.059
3.458LeuTyr: 3.458 ± 0.102
0.0LeuXaa: 0.0 ± 0.0
Met
1.747MetAla: 1.747 ± 0.071
0.213MetCys: 0.213 ± 0.025
0.955MetAsp: 0.955 ± 0.057
1.529MetGlu: 1.529 ± 0.059
0.699MetPhe: 0.699 ± 0.042
1.671MetGly: 1.671 ± 0.057
0.293MetHis: 0.293 ± 0.026
1.411MetIle: 1.411 ± 0.061
1.985MetLys: 1.985 ± 0.075
2.04MetLeu: 2.04 ± 0.071
0.561MetMet: 0.561 ± 0.041
0.707MetAsn: 0.707 ± 0.043
0.995MetPro: 0.995 ± 0.047
0.288MetGln: 0.288 ± 0.03
1.691MetArg: 1.691 ± 0.068
1.443MetSer: 1.443 ± 0.06
0.967MetThr: 0.967 ± 0.053
1.869MetVal: 1.869 ± 0.063
0.233MetTrp: 0.233 ± 0.024
0.614MetTyr: 0.614 ± 0.039
0.0MetXaa: 0.0 ± 0.0
Asn
2.298AsnAla: 2.298 ± 0.073
0.253AsnCys: 0.253 ± 0.029
1.118AsnAsp: 1.118 ± 0.049
1.759AsnGlu: 1.759 ± 0.065
1.118AsnPhe: 1.118 ± 0.06
1.604AsnGly: 1.604 ± 0.088
0.281AsnHis: 0.281 ± 0.028
1.243AsnIle: 1.243 ± 0.061
1.987AsnLys: 1.987 ± 0.075
2.932AsnLeu: 2.932 ± 0.095
0.641AsnMet: 0.641 ± 0.038
0.704AsnAsn: 0.704 ± 0.049
1.877AsnPro: 1.877 ± 0.083
0.328AsnGln: 0.328 ± 0.028
0.915AsnArg: 0.915 ± 0.052
1.306AsnSer: 1.306 ± 0.062
1.035AsnThr: 1.035 ± 0.044
3.29AsnVal: 3.29 ± 0.099
0.281AsnTrp: 0.281 ± 0.027
1.108AsnTyr: 1.108 ± 0.058
0.0AsnXaa: 0.0 ± 0.0
Pro
3.247ProAla: 3.247 ± 0.094
0.599ProCys: 0.599 ± 0.037
2.325ProAsp: 2.325 ± 0.089
4.899ProGlu: 4.899 ± 0.111
2.127ProPhe: 2.127 ± 0.069
3.651ProGly: 3.651 ± 0.107
0.89ProHis: 0.89 ± 0.047
2.097ProIle: 2.097 ± 0.073
3.618ProLys: 3.618 ± 0.104
5.455ProLeu: 5.455 ± 0.141
0.935ProMet: 0.935 ± 0.046
1.326ProAsn: 1.326 ± 0.062
3.313ProPro: 3.313 ± 0.095
1.1ProGln: 1.1 ± 0.055
2.576ProArg: 2.576 ± 0.081
3.157ProSer: 3.157 ± 0.088
2.137ProThr: 2.137 ± 0.076
3.982ProVal: 3.982 ± 0.106
0.932ProTrp: 0.932 ± 0.056
1.934ProTyr: 1.934 ± 0.07
0.0ProXaa: 0.0 ± 0.0
Gln
1.413GlnAla: 1.413 ± 0.059
0.198GlnCys: 0.198 ± 0.025
0.449GlnAsp: 0.449 ± 0.035
1.103GlnGlu: 1.103 ± 0.067
0.459GlnPhe: 0.459 ± 0.034
1.017GlnGly: 1.017 ± 0.052
0.251GlnHis: 0.251 ± 0.023
0.895GlnIle: 0.895 ± 0.049
1.175GlnLys: 1.175 ± 0.058
1.852GlnLeu: 1.852 ± 0.07
0.464GlnMet: 0.464 ± 0.036
0.398GlnAsn: 0.398 ± 0.027
0.614GlnPro: 0.614 ± 0.037
0.381GlnGln: 0.381 ± 0.029
1.248GlnArg: 1.248 ± 0.061
0.712GlnSer: 0.712 ± 0.039
0.654GlnThr: 0.654 ± 0.04
1.29GlnVal: 1.29 ± 0.053
0.208GlnTrp: 0.208 ± 0.023
0.566GlnTyr: 0.566 ± 0.043
0.0GlnXaa: 0.0 ± 0.0
Arg
5.49ArgAla: 5.49 ± 0.119
0.777ArgCys: 0.777 ± 0.05
2.293ArgAsp: 2.293 ± 0.073
5.265ArgGlu: 5.265 ± 0.118
1.912ArgPhe: 1.912 ± 0.066
5.052ArgGly: 5.052 ± 0.1
0.777ArgHis: 0.777 ± 0.045
2.606ArgIle: 2.606 ± 0.092
4.022ArgLys: 4.022 ± 0.104
5.934ArgLeu: 5.934 ± 0.124
1.361ArgMet: 1.361 ± 0.057
1.368ArgAsn: 1.368 ± 0.059
2.972ArgPro: 2.972 ± 0.098
0.759ArgGln: 0.759 ± 0.046
4.483ArgArg: 4.483 ± 0.134
2.872ArgSer: 2.872 ± 0.089
2.06ArgThr: 2.06 ± 0.072
5.57ArgVal: 5.57 ± 0.124
0.864ArgTrp: 0.864 ± 0.058
1.802ArgTyr: 1.802 ± 0.065
0.0ArgXaa: 0.0 ± 0.0
Ser
4.155SerAla: 4.155 ± 0.104
0.639SerCys: 0.639 ± 0.047
2.155SerAsp: 2.155 ± 0.076
4.084SerGlu: 4.084 ± 0.094
2.426SerPhe: 2.426 ± 0.087
3.999SerGly: 3.999 ± 0.105
0.757SerHis: 0.757 ± 0.037
2.408SerIle: 2.408 ± 0.078
3.962SerLys: 3.962 ± 0.103
6.741SerLeu: 6.741 ± 0.148
1.278SerMet: 1.278 ± 0.055
1.436SerAsn: 1.436 ± 0.059
3.167SerPro: 3.167 ± 0.098
1.055SerGln: 1.055 ± 0.047
2.548SerArg: 2.548 ± 0.084
3.596SerSer: 3.596 ± 0.108
2.365SerThr: 2.365 ± 0.087
4.703SerVal: 4.703 ± 0.109
0.837SerTrp: 0.837 ± 0.056
2.067SerTyr: 2.067 ± 0.08
0.0SerXaa: 0.0 ± 0.0
Thr
3.2ThrAla: 3.2 ± 0.104
0.486ThrCys: 0.486 ± 0.04
1.759ThrAsp: 1.759 ± 0.168
2.453ThrGlu: 2.453 ± 0.094
1.914ThrPhe: 1.914 ± 0.073
2.864ThrGly: 2.864 ± 0.09
0.667ThrHis: 0.667 ± 0.043
2.215ThrIle: 2.215 ± 0.077
2.641ThrLys: 2.641 ± 0.097
5.302ThrLeu: 5.302 ± 0.184
0.927ThrMet: 0.927 ± 0.05
1.28ThrAsn: 1.28 ± 0.063
2.481ThrPro: 2.481 ± 0.072
0.674ThrGln: 0.674 ± 0.039
1.847ThrArg: 1.847 ± 0.069
2.746ThrSer: 2.746 ± 0.11
2.213ThrThr: 2.213 ± 0.201
4.43ThrVal: 4.43 ± 0.169
0.511ThrTrp: 0.511 ± 0.036
1.549ThrTyr: 1.549 ± 0.06
0.0ThrXaa: 0.0 ± 0.0
Val
8.76ValAla: 8.76 ± 0.158
0.837ValCys: 0.837 ± 0.06
4.706ValAsp: 4.706 ± 0.101
8.597ValGlu: 8.597 ± 0.163
2.937ValPhe: 2.937 ± 0.09
6.585ValGly: 6.585 ± 0.136
1.461ValHis: 1.461 ± 0.055
5.412ValIle: 5.412 ± 0.103
7.525ValLys: 7.525 ± 0.128
9.524ValLeu: 9.524 ± 0.171
1.917ValMet: 1.917 ± 0.067
2.511ValAsn: 2.511 ± 0.087
5.265ValPro: 5.265 ± 0.117
1.438ValGln: 1.438 ± 0.055
5.658ValArg: 5.658 ± 0.131
5.164ValSer: 5.164 ± 0.123
4.796ValThr: 4.796 ± 0.195
10.191ValVal: 10.191 ± 0.179
1.138ValTrp: 1.138 ± 0.054
3.403ValTyr: 3.403 ± 0.104
0.0ValXaa: 0.0 ± 0.0
Trp
1.067TrpAla: 1.067 ± 0.049
0.155TrpCys: 0.155 ± 0.026
0.687TrpAsp: 0.687 ± 0.043
1.158TrpGlu: 1.158 ± 0.062
0.436TrpPhe: 0.436 ± 0.034
1.057TrpGly: 1.057 ± 0.05
0.19TrpHis: 0.19 ± 0.023
0.662TrpIle: 0.662 ± 0.04
1.123TrpLys: 1.123 ± 0.055
1.386TrpLeu: 1.386 ± 0.063
0.273TrpMet: 0.273 ± 0.028
0.398TrpAsn: 0.398 ± 0.03
0.501TrpPro: 0.501 ± 0.037
0.198TrpGln: 0.198 ± 0.023
1.113TrpArg: 1.113 ± 0.061
0.784TrpSer: 0.784 ± 0.044
0.589TrpThr: 0.589 ± 0.035
1.042TrpVal: 1.042 ± 0.055
0.308TrpTrp: 0.308 ± 0.032
0.444TrpTyr: 0.444 ± 0.032
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.06TyrAla: 3.06 ± 0.091
0.418TyrCys: 0.418 ± 0.034
1.884TyrAsp: 1.884 ± 0.073
2.859TyrGlu: 2.859 ± 0.088
1.483TyrPhe: 1.483 ± 0.055
2.561TyrGly: 2.561 ± 0.083
0.549TyrHis: 0.549 ± 0.05
1.421TyrIle: 1.421 ± 0.06
2.35TyrLys: 2.35 ± 0.076
4.044TyrLeu: 4.044 ± 0.098
0.659TyrMet: 0.659 ± 0.043
0.937TyrAsn: 0.937 ± 0.057
1.944TyrPro: 1.944 ± 0.07
0.762TyrGln: 0.762 ± 0.066
1.574TyrArg: 1.574 ± 0.068
2.26TyrSer: 2.26 ± 0.075
1.426TyrThr: 1.426 ± 0.054
3.744TyrVal: 3.744 ± 0.096
0.544TyrTrp: 0.544 ± 0.036
1.566TyrTyr: 1.566 ± 0.074
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1434 proteins (399079 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski