Amino acid dipepetide frequency for Desulfosporosinus meridiei (strain ATCC BAA-275 / DSM 13257 / KCTC 12902 / NCIMB 13706 / S10)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.474AlaAla: 6.474 ± 0.093
0.89AlaCys: 0.89 ± 0.029
3.627AlaAsp: 3.627 ± 0.055
5.212AlaGlu: 5.212 ± 0.083
3.004AlaPhe: 3.004 ± 0.052
5.898AlaGly: 5.898 ± 0.086
1.295AlaHis: 1.295 ± 0.031
5.558AlaIle: 5.558 ± 0.064
4.886AlaLys: 4.886 ± 0.069
8.46AlaLeu: 8.46 ± 0.095
2.082AlaMet: 2.082 ± 0.044
2.788AlaAsn: 2.788 ± 0.05
2.289AlaPro: 2.289 ± 0.069
3.01AlaGln: 3.01 ± 0.064
3.392AlaArg: 3.392 ± 0.056
4.139AlaSer: 4.139 ± 0.062
3.856AlaThr: 3.856 ± 0.315
5.698AlaVal: 5.698 ± 0.069
0.742AlaTrp: 0.742 ± 0.023
2.32AlaTyr: 2.32 ± 0.039
0.0AlaXaa: 0.0 ± 0.0
Cys
0.68CysAla: 0.68 ± 0.023
0.202CysCys: 0.202 ± 0.014
0.501CysAsp: 0.501 ± 0.022
0.568CysGlu: 0.568 ± 0.021
0.4CysPhe: 0.4 ± 0.017
1.133CysGly: 1.133 ± 0.039
0.277CysHis: 0.277 ± 0.019
0.714CysIle: 0.714 ± 0.023
0.523CysLys: 0.523 ± 0.022
1.132CysLeu: 1.132 ± 0.028
0.256CysMet: 0.256 ± 0.016
0.439CysAsn: 0.439 ± 0.017
0.633CysPro: 0.633 ± 0.029
0.461CysGln: 0.461 ± 0.021
0.517CysArg: 0.517 ± 0.02
0.795CysSer: 0.795 ± 0.026
0.551CysThr: 0.551 ± 0.02
0.638CysVal: 0.638 ± 0.023
0.109CysTrp: 0.109 ± 0.01
0.351CysTyr: 0.351 ± 0.02
0.0CysXaa: 0.0 ± 0.0
Asp
3.147AspAla: 3.147 ± 0.055
0.553AspCys: 0.553 ± 0.021
2.114AspAsp: 2.114 ± 0.045
3.381AspGlu: 3.381 ± 0.054
2.361AspPhe: 2.361 ± 0.042
3.195AspGly: 3.195 ± 0.058
0.82AspHis: 0.82 ± 0.027
4.012AspIle: 4.012 ± 0.056
2.993AspLys: 2.993 ± 0.046
5.565AspLeu: 5.565 ± 0.075
1.286AspMet: 1.286 ± 0.03
1.948AspAsn: 1.948 ± 0.042
2.179AspPro: 2.179 ± 0.04
1.937AspGln: 1.937 ± 0.038
2.283AspArg: 2.283 ± 0.039
2.871AspSer: 2.871 ± 0.059
2.242AspThr: 2.242 ± 0.05
3.448AspVal: 3.448 ± 0.133
0.61AspTrp: 0.61 ± 0.024
2.007AspTyr: 2.007 ± 0.042
0.0AspXaa: 0.0 ± 0.0
Glu
5.225GluAla: 5.225 ± 0.088
0.593GluCys: 0.593 ± 0.025
3.37GluAsp: 3.37 ± 0.052
5.684GluGlu: 5.684 ± 0.076
2.588GluPhe: 2.588 ± 0.05
4.473GluGly: 4.473 ± 0.066
1.242GluHis: 1.242 ± 0.033
5.666GluIle: 5.666 ± 0.072
5.137GluLys: 5.137 ± 0.064
7.198GluLeu: 7.198 ± 0.083
1.987GluMet: 1.987 ± 0.041
3.111GluAsn: 3.111 ± 0.045
1.877GluPro: 1.877 ± 0.038
2.817GluGln: 2.817 ± 0.053
3.513GluArg: 3.513 ± 0.061
3.5GluSer: 3.5 ± 0.059
3.286GluThr: 3.286 ± 0.048
5.017GluVal: 5.017 ± 0.06
0.721GluTrp: 0.721 ± 0.024
2.082GluTyr: 2.082 ± 0.039
0.0GluXaa: 0.0 ± 0.0
Phe
3.008PheAla: 3.008 ± 0.047
0.521PheCys: 0.521 ± 0.02
2.108PheAsp: 2.108 ± 0.048
2.431PheGlu: 2.431 ± 0.04
1.866PhePhe: 1.866 ± 0.045
3.119PheGly: 3.119 ± 0.052
0.671PheHis: 0.671 ± 0.024
3.066PheIle: 3.066 ± 0.049
2.157PheLys: 2.157 ± 0.042
4.335PheLeu: 4.335 ± 0.072
1.039PheMet: 1.039 ± 0.032
1.782PheAsn: 1.782 ± 0.04
1.684PhePro: 1.684 ± 0.038
1.373PheGln: 1.373 ± 0.036
1.747PheArg: 1.747 ± 0.039
3.136PheSer: 3.136 ± 0.054
2.229PheThr: 2.229 ± 0.042
2.751PheVal: 2.751 ± 0.048
0.485PheTrp: 0.485 ± 0.02
1.447PheTyr: 1.447 ± 0.034
0.0PheXaa: 0.0 ± 0.0
Gly
5.625GlyAla: 5.625 ± 0.316
1.025GlyCys: 1.025 ± 0.033
3.346GlyAsp: 3.346 ± 0.14
4.597GlyGlu: 4.597 ± 0.057
3.236GlyPhe: 3.236 ± 0.053
5.209GlyGly: 5.209 ± 0.078
1.331GlyHis: 1.331 ± 0.03
6.49GlyIle: 6.49 ± 0.079
5.058GlyLys: 5.058 ± 0.07
7.674GlyLeu: 7.674 ± 0.086
2.227GlyMet: 2.227 ± 0.045
2.836GlyAsn: 2.836 ± 0.057
1.806GlyPro: 1.806 ± 0.042
2.661GlyGln: 2.661 ± 0.054
3.103GlyArg: 3.103 ± 0.054
4.383GlySer: 4.383 ± 0.083
4.165GlyThr: 4.165 ± 0.064
5.562GlyVal: 5.562 ± 0.066
0.85GlyTrp: 0.85 ± 0.03
2.76GlyTyr: 2.76 ± 0.051
0.0GlyXaa: 0.0 ± 0.0
His
1.109HisAla: 1.109 ± 0.028
0.27HisCys: 0.27 ± 0.015
0.82HisAsp: 0.82 ± 0.025
1.09HisGlu: 1.09 ± 0.032
0.8HisPhe: 0.8 ± 0.026
1.254HisGly: 1.254 ± 0.033
0.455HisHis: 0.455 ± 0.023
1.188HisIle: 1.188 ± 0.027
0.92HisLys: 0.92 ± 0.029
1.898HisLeu: 1.898 ± 0.041
0.43HisMet: 0.43 ± 0.019
0.763HisAsn: 0.763 ± 0.025
1.042HisPro: 1.042 ± 0.033
0.692HisGln: 0.692 ± 0.022
0.842HisArg: 0.842 ± 0.023
1.137HisSer: 1.137 ± 0.028
0.894HisThr: 0.894 ± 0.029
1.023HisVal: 1.023 ± 0.027
0.218HisTrp: 0.218 ± 0.013
0.698HisTyr: 0.698 ± 0.025
0.0HisXaa: 0.0 ± 0.0
Ile
6.045IleAla: 6.045 ± 0.071
0.818IleCys: 0.818 ± 0.026
3.788IleAsp: 3.788 ± 0.06
5.026IleGlu: 5.026 ± 0.067
2.988IlePhe: 2.988 ± 0.05
5.694IleGly: 5.694 ± 0.068
1.35IleHis: 1.35 ± 0.035
5.704IleIle: 5.704 ± 0.079
4.429IleLys: 4.429 ± 0.065
7.864IleLeu: 7.864 ± 0.091
1.849IleMet: 1.849 ± 0.041
3.315IleAsn: 3.315 ± 0.057
3.599IlePro: 3.599 ± 0.056
2.578IleGln: 2.578 ± 0.047
3.441IleArg: 3.441 ± 0.053
5.361IleSer: 5.361 ± 0.075
3.992IleThr: 3.992 ± 0.06
5.207IleVal: 5.207 ± 0.073
0.649IleTrp: 0.649 ± 0.021
2.313IleTyr: 2.313 ± 0.049
0.0IleXaa: 0.0 ± 0.0
Lys
4.895LysAla: 4.895 ± 0.061
0.552LysCys: 0.552 ± 0.024
3.441LysAsp: 3.441 ± 0.058
5.171LysGlu: 5.171 ± 0.073
1.922LysPhe: 1.922 ± 0.04
4.213LysGly: 4.213 ± 0.057
1.017LysHis: 1.017 ± 0.029
4.732LysIle: 4.732 ± 0.066
4.054LysLys: 4.054 ± 0.059
5.796LysLeu: 5.796 ± 0.063
1.738LysMet: 1.738 ± 0.033
2.91LysAsn: 2.91 ± 0.05
2.249LysPro: 2.249 ± 0.042
2.285LysGln: 2.285 ± 0.046
2.854LysArg: 2.854 ± 0.053
3.569LysSer: 3.569 ± 0.054
3.435LysThr: 3.435 ± 0.051
4.724LysVal: 4.724 ± 0.06
0.592LysTrp: 0.592 ± 0.024
2.039LysTyr: 2.039 ± 0.042
0.0LysXaa: 0.0 ± 0.0
Leu
8.688LeuAla: 8.688 ± 0.101
1.005LeuCys: 1.005 ± 0.03
5.227LeuAsp: 5.227 ± 0.061
7.125LeuGlu: 7.125 ± 0.088
4.201LeuPhe: 4.201 ± 0.069
7.982LeuGly: 7.982 ± 0.096
1.67LeuHis: 1.67 ± 0.036
7.448LeuIle: 7.448 ± 0.086
6.938LeuLys: 6.938 ± 0.063
10.567LeuLeu: 10.567 ± 0.129
2.63LeuMet: 2.63 ± 0.043
4.693LeuAsn: 4.693 ± 0.058
4.324LeuPro: 4.324 ± 0.065
3.616LeuGln: 3.616 ± 0.06
4.799LeuArg: 4.799 ± 0.071
7.239LeuSer: 7.239 ± 0.075
6.033LeuThr: 6.033 ± 0.063
6.943LeuVal: 6.943 ± 0.076
1.009LeuTrp: 1.009 ± 0.033
2.896LeuTyr: 2.896 ± 0.05
0.0LeuXaa: 0.0 ± 0.0
Met
2.309MetAla: 2.309 ± 0.045
0.225MetCys: 0.225 ± 0.013
1.442MetAsp: 1.442 ± 0.033
1.73MetGlu: 1.73 ± 0.042
0.96MetPhe: 0.96 ± 0.027
2.061MetGly: 2.061 ± 0.048
0.412MetHis: 0.412 ± 0.019
1.978MetIle: 1.978 ± 0.043
1.767MetLys: 1.767 ± 0.038
2.487MetLeu: 2.487 ± 0.047
0.712MetMet: 0.712 ± 0.024
1.219MetAsn: 1.219 ± 0.033
1.015MetPro: 1.015 ± 0.028
0.816MetGln: 0.816 ± 0.026
1.169MetArg: 1.169 ± 0.032
1.766MetSer: 1.766 ± 0.036
1.492MetThr: 1.492 ± 0.034
1.867MetVal: 1.867 ± 0.037
0.181MetTrp: 0.181 ± 0.013
0.622MetTyr: 0.622 ± 0.021
0.0MetXaa: 0.0 ± 0.0
Asn
2.775AsnAla: 2.775 ± 0.047
0.523AsnCys: 0.523 ± 0.022
1.872AsnAsp: 1.872 ± 0.042
2.566AsnGlu: 2.566 ± 0.051
1.629AsnPhe: 1.629 ± 0.037
2.876AsnGly: 2.876 ± 0.052
0.842AsnHis: 0.842 ± 0.025
3.156AsnIle: 3.156 ± 0.059
2.465AsnLys: 2.465 ± 0.042
4.669AsnLeu: 4.669 ± 0.064
1.06AsnMet: 1.06 ± 0.028
1.905AsnAsn: 1.905 ± 0.045
2.373AsnPro: 2.373 ± 0.044
1.806AsnGln: 1.806 ± 0.04
1.896AsnArg: 1.896 ± 0.037
2.76AsnSer: 2.76 ± 0.042
2.15AsnThr: 2.15 ± 0.04
2.778AsnVal: 2.778 ± 0.047
0.503AsnTrp: 0.503 ± 0.023
1.678AsnTyr: 1.678 ± 0.036
0.0AsnXaa: 0.0 ± 0.0
Pro
2.616ProAla: 2.616 ± 0.045
0.343ProCys: 0.343 ± 0.015
2.106ProAsp: 2.106 ± 0.046
3.302ProGlu: 3.302 ± 0.055
1.696ProPhe: 1.696 ± 0.035
2.869ProGly: 2.869 ± 0.053
0.735ProHis: 0.735 ± 0.025
2.854ProIle: 2.854 ± 0.045
2.214ProLys: 2.214 ± 0.042
3.954ProLeu: 3.954 ± 0.05
0.875ProMet: 0.875 ± 0.025
1.62ProAsn: 1.62 ± 0.039
1.239ProPro: 1.239 ± 0.032
1.541ProGln: 1.541 ± 0.043
1.439ProArg: 1.439 ± 0.038
2.413ProSer: 2.413 ± 0.049
2.07ProThr: 2.07 ± 0.045
2.994ProVal: 2.994 ± 0.066
0.433ProTrp: 0.433 ± 0.019
1.262ProTyr: 1.262 ± 0.032
0.0ProXaa: 0.0 ± 0.0
Gln
3.257GlnAla: 3.257 ± 0.06
0.321GlnCys: 0.321 ± 0.015
1.717GlnAsp: 1.717 ± 0.035
3.104GlnGlu: 3.104 ± 0.054
1.279GlnPhe: 1.279 ± 0.031
2.897GlnGly: 2.897 ± 0.065
0.58GlnHis: 0.58 ± 0.019
2.897GlnIle: 2.897 ± 0.048
2.524GlnLys: 2.524 ± 0.054
3.628GlnLeu: 3.628 ± 0.062
1.02GlnMet: 1.02 ± 0.025
1.531GlnAsn: 1.531 ± 0.032
1.206GlnPro: 1.206 ± 0.03
1.526GlnGln: 1.526 ± 0.043
1.833GlnArg: 1.833 ± 0.042
2.04GlnSer: 2.04 ± 0.037
2.018GlnThr: 2.018 ± 0.04
2.736GlnVal: 2.736 ± 0.06
0.463GlnTrp: 0.463 ± 0.02
1.026GlnTyr: 1.026 ± 0.027
0.0GlnXaa: 0.0 ± 0.0
Arg
2.927ArgAla: 2.927 ± 0.05
0.477ArgCys: 0.477 ± 0.019
2.264ArgAsp: 2.264 ± 0.042
3.564ArgGlu: 3.564 ± 0.062
1.967ArgPhe: 1.967 ± 0.041
2.866ArgGly: 2.866 ± 0.055
0.8ArgHis: 0.8 ± 0.024
3.475ArgIle: 3.475 ± 0.053
2.987ArgLys: 2.987 ± 0.05
4.92ArgLeu: 4.92 ± 0.06
1.279ArgMet: 1.279 ± 0.032
1.884ArgAsn: 1.884 ± 0.038
1.581ArgPro: 1.581 ± 0.04
1.878ArgGln: 1.878 ± 0.042
2.325ArgArg: 2.325 ± 0.052
2.592ArgSer: 2.592 ± 0.053
2.176ArgThr: 2.176 ± 0.042
3.287ArgVal: 3.287 ± 0.055
0.495ArgTrp: 0.495 ± 0.02
1.595ArgTyr: 1.595 ± 0.037
0.0ArgXaa: 0.0 ± 0.0
Ser
4.381SerAla: 4.381 ± 0.06
0.694SerCys: 0.694 ± 0.026
2.867SerAsp: 2.867 ± 0.044
4.014SerGlu: 4.014 ± 0.053
2.847SerPhe: 2.847 ± 0.046
5.069SerGly: 5.069 ± 0.072
1.091SerHis: 1.091 ± 0.029
4.688SerIle: 4.688 ± 0.062
3.658SerLys: 3.658 ± 0.061
6.951SerLeu: 6.951 ± 0.078
1.62SerMet: 1.62 ± 0.036
2.502SerAsn: 2.502 ± 0.051
2.512SerPro: 2.512 ± 0.047
2.387SerGln: 2.387 ± 0.045
2.774SerArg: 2.774 ± 0.048
4.171SerSer: 4.171 ± 0.067
3.257SerThr: 3.257 ± 0.082
4.315SerVal: 4.315 ± 0.064
0.68SerTrp: 0.68 ± 0.028
2.097SerTyr: 2.097 ± 0.052
0.0SerXaa: 0.0 ± 0.0
Thr
4.046ThrAla: 4.046 ± 0.069
0.537ThrCys: 0.537 ± 0.022
2.543ThrAsp: 2.543 ± 0.05
3.173ThrGlu: 3.173 ± 0.051
2.17ThrPhe: 2.17 ± 0.042
4.863ThrGly: 4.863 ± 0.382
0.971ThrHis: 0.971 ± 0.025
3.985ThrIle: 3.985 ± 0.057
2.891ThrLys: 2.891 ± 0.047
5.683ThrLeu: 5.683 ± 0.059
1.294ThrMet: 1.294 ± 0.033
2.131ThrAsn: 2.131 ± 0.041
2.526ThrPro: 2.526 ± 0.047
1.829ThrGln: 1.829 ± 0.041
2.078ThrArg: 2.078 ± 0.041
3.147ThrSer: 3.147 ± 0.059
2.948ThrThr: 2.948 ± 0.059
4.027ThrVal: 4.027 ± 0.058
0.526ThrTrp: 0.526 ± 0.023
1.632ThrTyr: 1.632 ± 0.034
0.0ThrXaa: 0.0 ± 0.0
Val
5.431ValAla: 5.431 ± 0.082
0.844ValCys: 0.844 ± 0.025
3.591ValAsp: 3.591 ± 0.055
4.638ValGlu: 4.638 ± 0.066
3.037ValPhe: 3.037 ± 0.049
5.043ValGly: 5.043 ± 0.134
1.144ValHis: 1.144 ± 0.03
5.582ValIle: 5.582 ± 0.061
4.223ValLys: 4.223 ± 0.058
7.53ValLeu: 7.53 ± 0.087
1.918ValMet: 1.918 ± 0.038
3.006ValAsn: 3.006 ± 0.044
2.616ValPro: 2.616 ± 0.043
2.452ValGln: 2.452 ± 0.041
3.134ValArg: 3.134 ± 0.051
4.796ValSer: 4.796 ± 0.057
3.969ValThr: 3.969 ± 0.063
5.355ValVal: 5.355 ± 0.083
0.702ValTrp: 0.702 ± 0.029
2.109ValTyr: 2.109 ± 0.045
0.0ValXaa: 0.0 ± 0.0
Trp
0.746TrpAla: 0.746 ± 0.024
0.09TrpCys: 0.09 ± 0.008
0.506TrpAsp: 0.506 ± 0.02
0.73TrpGlu: 0.73 ± 0.024
0.42TrpPhe: 0.42 ± 0.017
0.856TrpGly: 0.856 ± 0.03
0.196TrpHis: 0.196 ± 0.013
0.719TrpIle: 0.719 ± 0.028
0.598TrpLys: 0.598 ± 0.019
1.154TrpLeu: 1.154 ± 0.03
0.245TrpMet: 0.245 ± 0.012
0.506TrpAsn: 0.506 ± 0.02
0.379TrpPro: 0.379 ± 0.018
0.52TrpGln: 0.52 ± 0.02
0.502TrpArg: 0.502 ± 0.019
0.61TrpSer: 0.61 ± 0.021
0.52TrpThr: 0.52 ± 0.021
0.725TrpVal: 0.725 ± 0.025
0.146TrpTrp: 0.146 ± 0.01
0.329TrpTyr: 0.329 ± 0.019
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.237TyrAla: 2.237 ± 0.038
0.398TyrCys: 0.398 ± 0.017
1.702TyrAsp: 1.702 ± 0.038
1.978TyrGlu: 1.978 ± 0.039
1.585TyrPhe: 1.585 ± 0.038
2.376TyrGly: 2.376 ± 0.045
0.645TyrHis: 0.645 ± 0.021
2.099TyrIle: 2.099 ± 0.045
1.767TyrLys: 1.767 ± 0.036
3.569TyrLeu: 3.569 ± 0.059
0.683TyrMet: 0.683 ± 0.022
1.392TyrAsn: 1.392 ± 0.037
1.444TyrPro: 1.444 ± 0.038
1.42TyrGln: 1.42 ± 0.037
1.698TyrArg: 1.698 ± 0.037
2.152TyrSer: 2.152 ± 0.042
1.714TyrThr: 1.714 ± 0.041
2.023TyrVal: 2.023 ± 0.039
0.383TyrTrp: 0.383 ± 0.016
1.295TyrTyr: 1.295 ± 0.034
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4340 proteins (1328786 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski