Amino acid dipepetide frequency for Bermanella marisrubri

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.816AlaAla: 6.816 ± 0.109	1.006AlaCys: 1.006 ± 0.034	4.544AlaAsp: 4.544 ± 0.067	5.285AlaGlu: 5.285 ± 0.08	3.404AlaPhe: 3.404 ± 0.065	5.666AlaGly: 5.666 ± 0.081	1.757AlaHis: 1.757 ± 0.048	5.899AlaIle: 5.899 ± 0.089	4.993AlaLys: 4.993 ± 0.09	9.224AlaLeu: 9.224 ± 0.13	2.727AlaMet: 2.727 ± 0.058	3.537AlaAsn: 3.537 ± 0.068	2.669AlaPro: 2.669 ± 0.057	4.006AlaGln: 4.006 ± 0.067	3.568AlaArg: 3.568 ± 0.07	5.34AlaSer: 5.34 ± 0.071	3.905AlaThr: 3.905 ± 0.061	5.344AlaVal: 5.344 ± 0.084	0.977AlaTrp: 0.977 ± 0.031	2.554AlaTyr: 2.554 ± 0.054	0.0AlaXaa: 0.0 ± 0.0
Cys	0.747CysAla: 0.747 ± 0.028	0.131CysCys: 0.131 ± 0.013	0.624CysAsp: 0.624 ± 0.027	0.605CysGlu: 0.605 ± 0.025	0.467CysPhe: 0.467 ± 0.018	0.791CysGly: 0.791 ± 0.031	0.309CysHis: 0.309 ± 0.018	0.625CysIle: 0.625 ± 0.027	0.445CysLys: 0.445 ± 0.024	1.006CysLeu: 1.006 ± 0.03	0.233CysMet: 0.233 ± 0.015	0.337CysAsn: 0.337 ± 0.02	0.428CysPro: 0.428 ± 0.02	0.475CysGln: 0.475 ± 0.023	0.433CysArg: 0.433 ± 0.019	0.612CysSer: 0.612 ± 0.026	0.421CysThr: 0.421 ± 0.019	0.596CysVal: 0.596 ± 0.023	0.109CysTrp: 0.109 ± 0.012	0.299CysTyr: 0.299 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	4.747AspAla: 4.747 ± 0.074	0.534AspCys: 0.534 ± 0.022	3.66AspAsp: 3.66 ± 0.069	4.495AspGlu: 4.495 ± 0.082	2.693AspPhe: 2.693 ± 0.054	4.083AspGly: 4.083 ± 0.079	1.346AspHis: 1.346 ± 0.039	4.198AspIle: 4.198 ± 0.064	3.097AspLys: 3.097 ± 0.051	5.9AspLeu: 5.9 ± 0.085	1.559AspMet: 1.559 ± 0.042	2.422AspAsn: 2.422 ± 0.063	2.299AspPro: 2.299 ± 0.055	2.612AspGln: 2.612 ± 0.051	2.634AspArg: 2.634 ± 0.059	3.539AspSer: 3.539 ± 0.067	2.846AspThr: 2.846 ± 0.062	4.3AspVal: 4.3 ± 0.069	0.845AspTrp: 0.845 ± 0.028	2.191AspTyr: 2.191 ± 0.051	0.0AspXaa: 0.0 ± 0.0
Glu	5.464GluAla: 5.464 ± 0.094	0.51GluCys: 0.51 ± 0.023	3.453GluAsp: 3.453 ± 0.063	4.349GluGlu: 4.349 ± 0.082	2.653GluPhe: 2.653 ± 0.05	3.807GluGly: 3.807 ± 0.06	1.686GluHis: 1.686 ± 0.041	4.096GluIle: 4.096 ± 0.063	4.093GluLys: 4.093 ± 0.074	6.871GluLeu: 6.871 ± 0.097	1.616GluMet: 1.616 ± 0.037	3.0GluAsn: 3.0 ± 0.059	2.159GluPro: 2.159 ± 0.049	4.145GluGln: 4.145 ± 0.072	3.402GluArg: 3.402 ± 0.062	4.237GluSer: 4.237 ± 0.069	3.331GluThr: 3.331 ± 0.062	4.268GluVal: 4.268 ± 0.073	0.756GluTrp: 0.756 ± 0.028	2.117GluTyr: 2.117 ± 0.052	0.0GluXaa: 0.0 ± 0.0
Phe	3.475PheAla: 3.475 ± 0.063	0.44PheCys: 0.44 ± 0.022	2.869PheAsp: 2.869 ± 0.057	2.65PheGlu: 2.65 ± 0.056	1.837PhePhe: 1.837 ± 0.051	2.84PheGly: 2.84 ± 0.06	0.873PheHis: 0.873 ± 0.029	2.772PheIle: 2.772 ± 0.054	2.224PheLys: 2.224 ± 0.047	3.516PheLeu: 3.516 ± 0.067	1.127PheMet: 1.127 ± 0.034	1.994PheAsn: 1.994 ± 0.043	1.427PhePro: 1.427 ± 0.038	1.387PheGln: 1.387 ± 0.037	1.507PheArg: 1.507 ± 0.04	3.256PheSer: 3.256 ± 0.06	2.186PheThr: 2.186 ± 0.05	2.655PheVal: 2.655 ± 0.061	0.544PheTrp: 0.544 ± 0.022	1.481PheTyr: 1.481 ± 0.039	0.0PheXaa: 0.0 ± 0.0
Gly	5.081GlyAla: 5.081 ± 0.08	0.804GlyCys: 0.804 ± 0.029	3.813GlyAsp: 3.813 ± 0.066	4.231GlyGlu: 4.231 ± 0.072	3.428GlyPhe: 3.428 ± 0.064	4.597GlyGly: 4.597 ± 0.084	1.624GlyHis: 1.624 ± 0.043	4.782GlyIle: 4.782 ± 0.066	3.788GlyLys: 3.788 ± 0.059	7.162GlyLeu: 7.162 ± 0.097	1.949GlyMet: 1.949 ± 0.045	2.643GlyAsn: 2.643 ± 0.055	1.829GlyPro: 1.829 ± 0.043	2.963GlyGln: 2.963 ± 0.054	3.172GlyArg: 3.172 ± 0.064	4.084GlySer: 4.084 ± 0.067	3.293GlyThr: 3.293 ± 0.063	4.675GlyVal: 4.675 ± 0.067	0.889GlyTrp: 0.889 ± 0.033	2.513GlyTyr: 2.513 ± 0.051	0.0GlyXaa: 0.0 ± 0.0
His	1.688HisAla: 1.688 ± 0.041	0.294HisCys: 0.294 ± 0.017	1.3HisAsp: 1.3 ± 0.029	1.438HisGlu: 1.438 ± 0.035	1.116HisPhe: 1.116 ± 0.037	1.701HisGly: 1.701 ± 0.039	0.769HisHis: 0.769 ± 0.032	1.555HisIle: 1.555 ± 0.039	1.174HisLys: 1.174 ± 0.037	2.231HisLeu: 2.231 ± 0.046	0.61HisMet: 0.61 ± 0.029	0.898HisAsn: 0.898 ± 0.032	1.146HisPro: 1.146 ± 0.035	1.186HisGln: 1.186 ± 0.038	1.116HisArg: 1.116 ± 0.036	1.476HisSer: 1.476 ± 0.039	1.048HisThr: 1.048 ± 0.031	1.375HisVal: 1.375 ± 0.039	0.409HisTrp: 0.409 ± 0.022	0.945HisTyr: 0.945 ± 0.033	0.0HisXaa: 0.0 ± 0.0
Ile	6.135IleAla: 6.135 ± 0.076	0.646IleCys: 0.646 ± 0.03	4.354IleAsp: 4.354 ± 0.061	5.181IleGlu: 5.181 ± 0.075	2.227IlePhe: 2.227 ± 0.053	4.189IleGly: 4.189 ± 0.074	1.466IleHis: 1.466 ± 0.041	3.637IleIle: 3.637 ± 0.07	3.567IleLys: 3.567 ± 0.056	5.444IleLeu: 5.444 ± 0.083	1.485IleMet: 1.485 ± 0.036	3.197IleAsn: 3.197 ± 0.069	2.619IlePro: 2.619 ± 0.058	2.841IleGln: 2.841 ± 0.057	2.985IleArg: 2.985 ± 0.051	4.445IleSer: 4.445 ± 0.081	3.432IleThr: 3.432 ± 0.065	3.966IleVal: 3.966 ± 0.069	0.625IleTrp: 0.625 ± 0.026	1.772IleTyr: 1.772 ± 0.044	0.0IleXaa: 0.0 ± 0.0
Lys	4.979LysAla: 4.979 ± 0.084	0.308LysCys: 0.308 ± 0.019	3.403LysAsp: 3.403 ± 0.053	3.527LysGlu: 3.527 ± 0.067	1.436LysPhe: 1.436 ± 0.034	3.546LysGly: 3.546 ± 0.058	1.417LysHis: 1.417 ± 0.038	2.857LysIle: 2.857 ± 0.049	3.234LysLys: 3.234 ± 0.083	5.103LysLeu: 5.103 ± 0.082	1.329LysMet: 1.329 ± 0.033	2.377LysAsn: 2.377 ± 0.059	2.461LysPro: 2.461 ± 0.053	3.597LysGln: 3.597 ± 0.068	3.1LysArg: 3.1 ± 0.051	3.177LysSer: 3.177 ± 0.063	2.917LysThr: 2.917 ± 0.047	3.665LysVal: 3.665 ± 0.068	0.625LysTrp: 0.625 ± 0.026	1.372LysTyr: 1.372 ± 0.034	0.0LysXaa: 0.0 ± 0.0
Leu	9.118LeuAla: 9.118 ± 0.113	0.965LeuCys: 0.965 ± 0.029	6.411LeuAsp: 6.411 ± 0.095	6.485LeuGlu: 6.485 ± 0.086	4.003LeuPhe: 4.003 ± 0.064	6.718LeuGly: 6.718 ± 0.082	2.124LeuHis: 2.124 ± 0.049	6.153LeuIle: 6.153 ± 0.083	5.93LeuLys: 5.93 ± 0.087	9.954LeuLeu: 9.954 ± 0.122	2.707LeuMet: 2.707 ± 0.048	4.807LeuAsn: 4.807 ± 0.073	4.463LeuPro: 4.463 ± 0.07	4.169LeuGln: 4.169 ± 0.067	4.29LeuArg: 4.29 ± 0.076	7.67LeuSer: 7.67 ± 0.086	5.222LeuThr: 5.222 ± 0.083	6.559LeuVal: 6.559 ± 0.09	1.032LeuTrp: 1.032 ± 0.035	2.706LeuTyr: 2.706 ± 0.051	0.0LeuXaa: 0.0 ± 0.0
Met	2.56MetAla: 2.56 ± 0.057	0.187MetCys: 0.187 ± 0.015	1.539MetAsp: 1.539 ± 0.042	1.51MetGlu: 1.51 ± 0.035	0.814MetPhe: 0.814 ± 0.031	1.963MetGly: 1.963 ± 0.049	0.568MetHis: 0.568 ± 0.022	1.459MetIle: 1.459 ± 0.038	1.456MetLys: 1.456 ± 0.04	2.543MetLeu: 2.543 ± 0.048	0.733MetMet: 0.733 ± 0.028	1.137MetAsn: 1.137 ± 0.036	1.232MetPro: 1.232 ± 0.034	1.215MetGln: 1.215 ± 0.036	1.316MetArg: 1.316 ± 0.039	1.98MetSer: 1.98 ± 0.041	1.444MetThr: 1.444 ± 0.04	1.768MetVal: 1.768 ± 0.046	0.224MetTrp: 0.224 ± 0.015	0.511MetTyr: 0.511 ± 0.022	0.0MetXaa: 0.0 ± 0.0
Asn	3.515AsnAla: 3.515 ± 0.061	0.398AsnCys: 0.398 ± 0.021	2.497AsnAsp: 2.497 ± 0.066	2.72AsnGlu: 2.72 ± 0.053	1.479AsnPhe: 1.479 ± 0.039	3.133AsnGly: 3.133 ± 0.068	1.039AsnHis: 1.039 ± 0.034	2.984AsnIle: 2.984 ± 0.066	2.324AsnLys: 2.324 ± 0.047	4.071AsnLeu: 4.071 ± 0.075	1.012AsnMet: 1.012 ± 0.03	1.936AsnAsn: 1.936 ± 0.054	2.183AsnPro: 2.183 ± 0.046	2.352AsnGln: 2.352 ± 0.056	2.068AsnArg: 2.068 ± 0.046	2.632AsnSer: 2.632 ± 0.059	2.351AsnThr: 2.351 ± 0.057	2.678AsnVal: 2.678 ± 0.049	0.624AsnTrp: 0.624 ± 0.023	1.327AsnTyr: 1.327 ± 0.039	0.0AsnXaa: 0.0 ± 0.0
Pro	2.8ProAla: 2.8 ± 0.053	0.34ProCys: 0.34 ± 0.015	2.537ProAsp: 2.537 ± 0.055	3.128ProGlu: 3.128 ± 0.059	1.717ProPhe: 1.717 ± 0.042	2.393ProGly: 2.393 ± 0.048	0.847ProHis: 0.847 ± 0.032	2.589ProIle: 2.589 ± 0.056	2.27ProLys: 2.27 ± 0.051	3.82ProLeu: 3.82 ± 0.069	1.057ProMet: 1.057 ± 0.031	1.873ProAsn: 1.873 ± 0.045	1.098ProPro: 1.098 ± 0.035	1.723ProGln: 1.723 ± 0.048	1.297ProArg: 1.297 ± 0.034	2.488ProSer: 2.488 ± 0.044	1.787ProThr: 1.787 ± 0.048	3.014ProVal: 3.014 ± 0.049	0.56ProTrp: 0.56 ± 0.026	1.305ProTyr: 1.305 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	4.72GlnAla: 4.72 ± 0.078	0.42GlnCys: 0.42 ± 0.023	2.626GlnAsp: 2.626 ± 0.052	2.965GlnGlu: 2.965 ± 0.055	1.882GlnPhe: 1.882 ± 0.042	3.324GlnGly: 3.324 ± 0.057	1.299GlnHis: 1.299 ± 0.035	2.711GlnIle: 2.711 ± 0.049	2.386GlnLys: 2.386 ± 0.054	4.957GlnLeu: 4.957 ± 0.077	1.101GlnMet: 1.101 ± 0.034	1.934GlnAsn: 1.934 ± 0.049	1.756GlnPro: 1.756 ± 0.047	3.079GlnGln: 3.079 ± 0.068	2.35GlnArg: 2.35 ± 0.049	3.239GlnSer: 3.239 ± 0.052	2.504GlnThr: 2.504 ± 0.054	3.386GlnVal: 3.386 ± 0.056	0.774GlnTrp: 0.774 ± 0.029	1.64GlnTyr: 1.64 ± 0.037	0.0GlnXaa: 0.0 ± 0.0
Arg	3.259ArgAla: 3.259 ± 0.057	0.458ArgCys: 0.458 ± 0.021	2.515ArgAsp: 2.515 ± 0.051	2.923ArgGlu: 2.923 ± 0.057	2.311ArgPhe: 2.311 ± 0.051	2.5ArgGly: 2.5 ± 0.053	1.205ArgHis: 1.205 ± 0.035	3.358ArgIle: 3.358 ± 0.065	2.343ArgLys: 2.343 ± 0.049	5.331ArgLeu: 5.331 ± 0.072	1.252ArgMet: 1.252 ± 0.033	1.905ArgAsn: 1.905 ± 0.048	1.69ArgPro: 1.69 ± 0.042	2.326ArgGln: 2.326 ± 0.044	2.291ArgArg: 2.291 ± 0.061	2.731ArgSer: 2.731 ± 0.056	2.139ArgThr: 2.139 ± 0.045	2.933ArgVal: 2.933 ± 0.057	0.594ArgTrp: 0.594 ± 0.024	1.837ArgTyr: 1.837 ± 0.037	0.0ArgXaa: 0.0 ± 0.0
Ser	5.17SerAla: 5.17 ± 0.072	0.538SerCys: 0.538 ± 0.023	4.142SerAsp: 4.142 ± 0.068	4.42SerGlu: 4.42 ± 0.082	2.795SerPhe: 2.795 ± 0.058	4.976SerGly: 4.976 ± 0.076	1.525SerHis: 1.525 ± 0.039	4.575SerIle: 4.575 ± 0.075	3.365SerLys: 3.365 ± 0.06	6.969SerLeu: 6.969 ± 0.084	1.708SerMet: 1.708 ± 0.043	2.878SerAsn: 2.878 ± 0.059	2.298SerPro: 2.298 ± 0.046	3.22SerGln: 3.22 ± 0.058	2.812SerArg: 2.812 ± 0.056	4.317SerSer: 4.317 ± 0.091	3.092SerThr: 3.092 ± 0.058	4.374SerVal: 4.374 ± 0.073	0.787SerTrp: 0.787 ± 0.027	1.934SerTyr: 1.934 ± 0.05	0.0SerXaa: 0.0 ± 0.0
Thr	4.08ThrAla: 4.08 ± 0.064	0.473ThrCys: 0.473 ± 0.022	2.898ThrAsp: 2.898 ± 0.073	3.085ThrGlu: 3.085 ± 0.054	1.925ThrPhe: 1.925 ± 0.042	3.909ThrGly: 3.909 ± 0.073	1.146ThrHis: 1.146 ± 0.034	3.089ThrIle: 3.089 ± 0.062	2.128ThrLys: 2.128 ± 0.047	5.826ThrLeu: 5.826 ± 0.068	1.119ThrMet: 1.119 ± 0.03	1.945ThrAsn: 1.945 ± 0.049	2.507ThrPro: 2.507 ± 0.047	2.551ThrGln: 2.551 ± 0.048	2.158ThrArg: 2.158 ± 0.047	3.221ThrSer: 3.221 ± 0.069	2.585ThrThr: 2.585 ± 0.059	3.24ThrVal: 3.24 ± 0.063	0.618ThrTrp: 0.618 ± 0.024	1.478ThrTyr: 1.478 ± 0.042	0.0ThrXaa: 0.0 ± 0.0
Val	5.813ValAla: 5.813 ± 0.085	0.725ValCys: 0.725 ± 0.029	4.261ValAsp: 4.261 ± 0.077	4.454ValGlu: 4.454 ± 0.067	2.794ValPhe: 2.794 ± 0.059	4.264ValGly: 4.264 ± 0.074	1.365ValHis: 1.365 ± 0.038	4.382ValIle: 4.382 ± 0.081	3.59ValLys: 3.59 ± 0.062	6.641ValLeu: 6.641 ± 0.09	1.802ValMet: 1.802 ± 0.046	2.885ValAsn: 2.885 ± 0.052	2.548ValPro: 2.548 ± 0.044	2.379ValGln: 2.379 ± 0.048	2.914ValArg: 2.914 ± 0.06	4.588ValSer: 4.588 ± 0.069	3.554ValThr: 3.554 ± 0.067	4.869ValVal: 4.869 ± 0.069	0.68ValTrp: 0.68 ± 0.026	1.903ValTyr: 1.903 ± 0.043	0.0ValXaa: 0.0 ± 0.0
Trp	0.766TrpAla: 0.766 ± 0.024	0.144TrpCys: 0.144 ± 0.013	0.658TrpAsp: 0.658 ± 0.027	0.535TrpGlu: 0.535 ± 0.02	0.627TrpPhe: 0.627 ± 0.027	0.748TrpGly: 0.748 ± 0.031	0.345TrpHis: 0.345 ± 0.019	0.793TrpIle: 0.793 ± 0.03	0.528TrpLys: 0.528 ± 0.024	1.595TrpLeu: 1.595 ± 0.042	0.366TrpMet: 0.366 ± 0.019	0.444TrpAsn: 0.444 ± 0.021	0.467TrpPro: 0.467 ± 0.024	1.0TrpGln: 1.0 ± 0.033	0.672TrpArg: 0.672 ± 0.026	0.748TrpSer: 0.748 ± 0.026	0.491TrpThr: 0.491 ± 0.024	0.901TrpVal: 0.901 ± 0.03	0.205TrpTrp: 0.205 ± 0.016	0.378TrpTyr: 0.378 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.289TyrAla: 2.289 ± 0.05	0.371TyrCys: 0.371 ± 0.02	1.896TyrAsp: 1.896 ± 0.052	2.028TyrGlu: 2.028 ± 0.045	1.45TyrPhe: 1.45 ± 0.035	2.174TyrGly: 2.174 ± 0.053	0.766TyrHis: 0.766 ± 0.026	1.702TyrIle: 1.702 ± 0.045	1.494TyrLys: 1.494 ± 0.037	3.322TyrLeu: 3.322 ± 0.06	0.665TyrMet: 0.665 ± 0.025	1.175TyrAsn: 1.175 ± 0.033	1.363TyrPro: 1.363 ± 0.037	1.828TyrGln: 1.828 ± 0.042	1.818TyrArg: 1.818 ± 0.05	2.114TyrSer: 2.114 ± 0.047	1.432TyrThr: 1.432 ± 0.043	1.843TyrVal: 1.843 ± 0.042	0.535TyrTrp: 0.535 ± 0.023	1.046TyrTyr: 1.046 ± 0.032	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3303 proteins (1063161 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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