Amino acid dipepetide frequency for Coriobacteriaceae bacterium

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
14.961AlaAla: 14.961 ± 0.299
1.876AlaCys: 1.876 ± 0.065
6.085AlaAsp: 6.085 ± 0.12
6.214AlaGlu: 6.214 ± 0.121
3.862AlaPhe: 3.862 ± 0.086
8.696AlaGly: 8.696 ± 0.159
2.403AlaHis: 2.403 ± 0.07
5.588AlaIle: 5.588 ± 0.111
4.567AlaLys: 4.567 ± 0.122
11.468AlaLeu: 11.468 ± 0.21
3.152AlaMet: 3.152 ± 0.085
3.352AlaAsn: 3.352 ± 0.076
5.332AlaPro: 5.332 ± 0.139
6.065AlaGln: 6.065 ± 0.148
5.755AlaArg: 5.755 ± 0.12
7.465AlaSer: 7.465 ± 0.138
6.104AlaThr: 6.104 ± 0.094
7.723AlaVal: 7.723 ± 0.132
1.299AlaTrp: 1.299 ± 0.054
2.998AlaTyr: 2.998 ± 0.075
0.0AlaXaa: 0.0 ± 0.0
Cys
1.769CysAla: 1.769 ± 0.061
0.302CysCys: 0.302 ± 0.027
1.041CysAsp: 1.041 ± 0.047
0.947CysGlu: 0.947 ± 0.041
0.489CysPhe: 0.489 ± 0.03
1.663CysGly: 1.663 ± 0.061
0.353CysHis: 0.353 ± 0.024
0.783CysIle: 0.783 ± 0.045
0.419CysLys: 0.419 ± 0.028
1.277CysLeu: 1.277 ± 0.048
0.292CysMet: 0.292 ± 0.022
0.35CysAsn: 0.35 ± 0.025
0.767CysPro: 0.767 ± 0.044
0.512CysGln: 0.512 ± 0.029
0.79CysArg: 0.79 ± 0.037
0.836CysSer: 0.836 ± 0.042
0.786CysThr: 0.786 ± 0.036
1.284CysVal: 1.284 ± 0.051
0.193CysTrp: 0.193 ± 0.019
0.353CysTyr: 0.353 ± 0.028
0.0CysXaa: 0.0 ± 0.0
Asp
7.316AspAla: 7.316 ± 0.121
0.673AspCys: 0.673 ± 0.033
3.648AspAsp: 3.648 ± 0.096
4.498AspGlu: 4.498 ± 0.1
2.265AspPhe: 2.265 ± 0.07
5.228AspGly: 5.228 ± 0.14
1.166AspHis: 1.166 ± 0.048
2.963AspIle: 2.963 ± 0.069
2.205AspLys: 2.205 ± 0.064
6.081AspLeu: 6.081 ± 0.14
1.352AspMet: 1.352 ± 0.057
1.731AspAsn: 1.731 ± 0.069
4.202AspPro: 4.202 ± 0.135
1.931AspGln: 1.931 ± 0.065
3.154AspArg: 3.154 ± 0.062
3.254AspSer: 3.254 ± 0.084
3.126AspThr: 3.126 ± 0.093
4.564AspVal: 4.564 ± 0.092
0.707AspTrp: 0.707 ± 0.04
1.908AspTyr: 1.908 ± 0.058
0.0AspXaa: 0.0 ± 0.0
Glu
8.089GluAla: 8.089 ± 0.163
0.631GluCys: 0.631 ± 0.042
3.675GluAsp: 3.675 ± 0.093
4.283GluGlu: 4.283 ± 0.109
1.779GluPhe: 1.779 ± 0.062
5.027GluGly: 5.027 ± 0.093
1.323GluHis: 1.323 ± 0.045
2.905GluIle: 2.905 ± 0.07
2.83GluLys: 2.83 ± 0.07
6.332GluLeu: 6.332 ± 0.125
1.431GluMet: 1.431 ± 0.061
1.924GluAsn: 1.924 ± 0.06
2.912GluPro: 2.912 ± 0.085
2.422GluGln: 2.422 ± 0.061
4.131GluArg: 4.131 ± 0.099
3.156GluSer: 3.156 ± 0.07
3.073GluThr: 3.073 ± 0.074
4.882GluVal: 4.882 ± 0.103
0.491GluTrp: 0.491 ± 0.031
1.368GluTyr: 1.368 ± 0.056
0.0GluXaa: 0.0 ± 0.0
Phe
3.463PheAla: 3.463 ± 0.087
0.708PheCys: 0.708 ± 0.039
2.799PheAsp: 2.799 ± 0.072
2.249PheGlu: 2.249 ± 0.073
1.299PhePhe: 1.299 ± 0.048
3.06PheGly: 3.06 ± 0.089
0.601PheHis: 0.601 ± 0.032
1.62PheIle: 1.62 ± 0.061
1.18PheLys: 1.18 ± 0.044
2.866PheLeu: 2.866 ± 0.089
0.859PheMet: 0.859 ± 0.041
1.064PheAsn: 1.064 ± 0.046
1.239PhePro: 1.239 ± 0.05
0.908PheGln: 0.908 ± 0.03
1.38PheArg: 1.38 ± 0.049
2.572PheSer: 2.572 ± 0.069
1.839PheThr: 1.839 ± 0.056
2.686PheVal: 2.686 ± 0.073
0.479PheTrp: 0.479 ± 0.029
1.018PheTyr: 1.018 ± 0.043
0.0PheXaa: 0.0 ± 0.0
Gly
8.716GlyAla: 8.716 ± 0.157
1.452GlyCys: 1.452 ± 0.057
4.694GlyAsp: 4.694 ± 0.109
4.378GlyGlu: 4.378 ± 0.095
3.191GlyPhe: 3.191 ± 0.085
6.122GlyGly: 6.122 ± 0.154
1.673GlyHis: 1.673 ± 0.056
4.472GlyIle: 4.472 ± 0.094
3.193GlyLys: 3.193 ± 0.096
7.567GlyLeu: 7.567 ± 0.119
2.088GlyMet: 2.088 ± 0.064
2.341GlyAsn: 2.341 ± 0.081
2.753GlyPro: 2.753 ± 0.072
2.924GlyGln: 2.924 ± 0.072
4.223GlyArg: 4.223 ± 0.098
5.27GlySer: 5.27 ± 0.125
5.037GlyThr: 5.037 ± 0.12
6.212GlyVal: 6.212 ± 0.119
1.186GlyTrp: 1.186 ± 0.064
2.696GlyTyr: 2.696 ± 0.074
0.0GlyXaa: 0.0 ± 0.0
His
1.795HisAla: 1.795 ± 0.054
0.233HisCys: 0.233 ± 0.02
1.277HisAsp: 1.277 ± 0.047
1.408HisGlu: 1.408 ± 0.057
0.684HisPhe: 0.684 ± 0.037
1.654HisGly: 1.654 ± 0.055
0.495HisHis: 0.495 ± 0.03
0.972HisIle: 0.972 ± 0.042
0.708HisLys: 0.708 ± 0.034
1.864HisLeu: 1.864 ± 0.056
0.436HisMet: 0.436 ± 0.03
0.618HisAsn: 0.618 ± 0.035
1.239HisPro: 1.239 ± 0.052
0.694HisGln: 0.694 ± 0.03
1.095HisArg: 1.095 ± 0.04
1.076HisSer: 1.076 ± 0.045
1.078HisThr: 1.078 ± 0.038
1.458HisVal: 1.458 ± 0.053
0.21HisTrp: 0.21 ± 0.021
0.631HisTyr: 0.631 ± 0.034
0.0HisXaa: 0.0 ± 0.0
Ile
5.565IleAla: 5.565 ± 0.11
0.894IleCys: 0.894 ± 0.044
3.85IleAsp: 3.85 ± 0.079
3.318IleGlu: 3.318 ± 0.072
1.578IlePhe: 1.578 ± 0.065
3.567IleGly: 3.567 ± 0.097
0.892IleHis: 0.892 ± 0.044
2.362IleIle: 2.362 ± 0.077
1.868IleLys: 1.868 ± 0.063
4.097IleLeu: 4.097 ± 0.098
1.157IleMet: 1.157 ± 0.047
1.523IleAsn: 1.523 ± 0.054
2.572IlePro: 2.572 ± 0.062
1.585IleGln: 1.585 ± 0.058
2.189IleArg: 2.189 ± 0.071
3.034IleSer: 3.034 ± 0.079
2.88IleThr: 2.88 ± 0.077
4.016IleVal: 4.016 ± 0.094
0.488IleTrp: 0.488 ± 0.029
1.394IleTyr: 1.394 ± 0.057
0.0IleXaa: 0.0 ± 0.0
Lys
4.511LysAla: 4.511 ± 0.113
0.322LysCys: 0.322 ± 0.022
2.62LysAsp: 2.62 ± 0.071
2.507LysGlu: 2.507 ± 0.073
0.822LysPhe: 0.822 ± 0.044
2.843LysGly: 2.843 ± 0.075
0.643LysHis: 0.643 ± 0.033
1.841LysIle: 1.841 ± 0.064
1.846LysLys: 1.846 ± 0.06
3.258LysLeu: 3.258 ± 0.078
0.751LysMet: 0.751 ± 0.037
1.348LysAsn: 1.348 ± 0.049
2.345LysPro: 2.345 ± 0.095
1.164LysGln: 1.164 ± 0.046
2.398LysArg: 2.398 ± 0.069
2.141LysSer: 2.141 ± 0.074
2.362LysThr: 2.362 ± 0.065
2.919LysVal: 2.919 ± 0.08
0.261LysTrp: 0.261 ± 0.024
0.832LysTyr: 0.832 ± 0.038
0.0LysXaa: 0.0 ± 0.0
Leu
11.498LeuAla: 11.498 ± 0.17
1.671LeuCys: 1.671 ± 0.053
6.375LeuAsp: 6.375 ± 0.137
6.278LeuGlu: 6.278 ± 0.133
3.171LeuPhe: 3.171 ± 0.096
7.889LeuGly: 7.889 ± 0.14
1.569LeuHis: 1.569 ± 0.054
4.24LeuIle: 4.24 ± 0.097
3.668LeuLys: 3.668 ± 0.079
8.753LeuLeu: 8.753 ± 0.175
2.62LeuMet: 2.62 ± 0.08
2.403LeuAsn: 2.403 ± 0.063
4.574LeuPro: 4.574 ± 0.095
2.671LeuGln: 2.671 ± 0.066
4.919LeuArg: 4.919 ± 0.106
6.504LeuSer: 6.504 ± 0.113
5.265LeuThr: 5.265 ± 0.098
7.891LeuVal: 7.891 ± 0.124
1.131LeuTrp: 1.131 ± 0.052
2.325LeuTyr: 2.325 ± 0.074
0.0LeuXaa: 0.0 ± 0.0
Met
3.452MetAla: 3.452 ± 0.091
0.284MetCys: 0.284 ± 0.026
1.656MetAsp: 1.656 ± 0.055
1.486MetGlu: 1.486 ± 0.051
0.647MetPhe: 0.647 ± 0.038
2.24MetGly: 2.24 ± 0.074
0.419MetHis: 0.419 ± 0.031
1.027MetIle: 1.027 ± 0.04
0.896MetLys: 0.896 ± 0.042
2.235MetLeu: 2.235 ± 0.057
0.569MetMet: 0.569 ± 0.034
0.88MetAsn: 0.88 ± 0.035
1.382MetPro: 1.382 ± 0.05
0.643MetGln: 0.643 ± 0.038
1.406MetArg: 1.406 ± 0.053
1.539MetSer: 1.539 ± 0.052
1.329MetThr: 1.329 ± 0.047
1.871MetVal: 1.871 ± 0.053
0.159MetTrp: 0.159 ± 0.016
0.466MetTyr: 0.466 ± 0.028
0.0MetXaa: 0.0 ± 0.0
Asn
3.148AsnAla: 3.148 ± 0.092
0.348AsnCys: 0.348 ± 0.027
1.719AsnAsp: 1.719 ± 0.057
1.546AsnGlu: 1.546 ± 0.054
0.887AsnPhe: 0.887 ± 0.04
2.516AsnGly: 2.516 ± 0.078
0.655AsnHis: 0.655 ± 0.035
1.572AsnIle: 1.572 ± 0.069
0.989AsnLys: 0.989 ± 0.047
2.818AsnLeu: 2.818 ± 0.07
0.634AsnMet: 0.634 ± 0.036
0.883AsnAsn: 0.883 ± 0.049
2.21AsnPro: 2.21 ± 0.088
1.021AsnGln: 1.021 ± 0.048
1.498AsnArg: 1.498 ± 0.053
1.53AsnSer: 1.53 ± 0.058
1.656AsnThr: 1.656 ± 0.067
2.258AsnVal: 2.258 ± 0.071
0.329AsnTrp: 0.329 ± 0.023
0.926AsnTyr: 0.926 ± 0.046
0.0AsnXaa: 0.0 ± 0.0
Pro
5.668ProAla: 5.668 ± 0.127
0.643ProCys: 0.643 ± 0.035
3.18ProAsp: 3.18 ± 0.114
4.018ProGlu: 4.018 ± 0.091
1.64ProPhe: 1.64 ± 0.05
3.838ProGly: 3.838 ± 0.101
0.988ProHis: 0.988 ± 0.038
2.076ProIle: 2.076 ± 0.058
1.873ProLys: 1.873 ± 0.067
4.288ProLeu: 4.288 ± 0.101
1.002ProMet: 1.002 ± 0.042
1.32ProAsn: 1.32 ± 0.047
1.288ProPro: 1.288 ± 0.049
2.627ProGln: 2.627 ± 0.078
2.156ProArg: 2.156 ± 0.066
3.32ProSer: 3.32 ± 0.094
2.679ProThr: 2.679 ± 0.079
4.221ProVal: 4.221 ± 0.095
0.622ProTrp: 0.622 ± 0.039
1.447ProTyr: 1.447 ± 0.052
0.0ProXaa: 0.0 ± 0.0
Gln
4.68GlnAla: 4.68 ± 0.113
0.376GlnCys: 0.376 ± 0.029
2.24GlnAsp: 2.24 ± 0.069
3.048GlnGlu: 3.048 ± 0.093
0.903GlnPhe: 0.903 ± 0.043
3.09GlnGly: 3.09 ± 0.081
0.541GlnHis: 0.541 ± 0.031
1.788GlnIle: 1.788 ± 0.052
1.516GlnLys: 1.516 ± 0.057
3.795GlnLeu: 3.795 ± 0.094
0.94GlnMet: 0.94 ± 0.036
0.956GlnAsn: 0.956 ± 0.043
1.663GlnPro: 1.663 ± 0.065
1.442GlnGln: 1.442 ± 0.067
2.327GlnArg: 2.327 ± 0.078
1.868GlnSer: 1.868 ± 0.053
1.772GlnThr: 1.772 ± 0.054
3.675GlnVal: 3.675 ± 0.084
0.528GlnTrp: 0.528 ± 0.033
0.74GlnTyr: 0.74 ± 0.036
0.0GlnXaa: 0.0 ± 0.0
Arg
5.315ArgAla: 5.315 ± 0.114
0.855ArgCys: 0.855 ± 0.045
3.055ArgAsp: 3.055 ± 0.077
3.511ArgGlu: 3.511 ± 0.094
2.117ArgPhe: 2.117 ± 0.062
3.493ArgGly: 3.493 ± 0.093
1.118ArgHis: 1.118 ± 0.046
2.891ArgIle: 2.891 ± 0.075
1.988ArgLys: 1.988 ± 0.059
5.49ArgLeu: 5.49 ± 0.127
1.504ArgMet: 1.504 ± 0.057
1.382ArgAsn: 1.382 ± 0.058
2.463ArgPro: 2.463 ± 0.062
2.398ArgGln: 2.398 ± 0.065
3.947ArgArg: 3.947 ± 0.117
3.131ArgSer: 3.131 ± 0.075
2.991ArgThr: 2.991 ± 0.072
3.928ArgVal: 3.928 ± 0.101
0.7ArgTrp: 0.7 ± 0.031
1.848ArgTyr: 1.848 ± 0.053
0.0ArgXaa: 0.0 ± 0.0
Ser
6.49SerAla: 6.49 ± 0.128
0.966SerCys: 0.966 ± 0.044
3.216SerAsp: 3.216 ± 0.082
3.251SerGlu: 3.251 ± 0.079
2.346SerPhe: 2.346 ± 0.062
5.361SerGly: 5.361 ± 0.112
1.376SerHis: 1.376 ± 0.048
2.954SerIle: 2.954 ± 0.072
2.164SerLys: 2.164 ± 0.068
6.316SerLeu: 6.316 ± 0.115
1.731SerMet: 1.731 ± 0.053
1.754SerAsn: 1.754 ± 0.058
2.698SerPro: 2.698 ± 0.074
2.77SerGln: 2.77 ± 0.076
3.539SerArg: 3.539 ± 0.085
4.194SerSer: 4.194 ± 0.102
3.228SerThr: 3.228 ± 0.068
4.689SerVal: 4.689 ± 0.1
0.878SerTrp: 0.878 ± 0.042
1.933SerTyr: 1.933 ± 0.06
0.0SerXaa: 0.0 ± 0.0
Thr
5.194ThrAla: 5.194 ± 0.104
0.887ThrCys: 0.887 ± 0.038
2.816ThrAsp: 2.816 ± 0.071
2.364ThrGlu: 2.364 ± 0.07
2.189ThrPhe: 2.189 ± 0.067
4.77ThrGly: 4.77 ± 0.103
1.263ThrHis: 1.263 ± 0.045
2.975ThrIle: 2.975 ± 0.081
1.853ThrLys: 1.853 ± 0.061
5.732ThrLeu: 5.732 ± 0.094
1.281ThrMet: 1.281 ± 0.047
1.656ThrAsn: 1.656 ± 0.073
3.594ThrPro: 3.594 ± 0.095
2.329ThrGln: 2.329 ± 0.075
2.562ThrArg: 2.562 ± 0.069
3.656ThrSer: 3.656 ± 0.074
2.998ThrThr: 2.998 ± 0.08
4.532ThrVal: 4.532 ± 0.108
0.631ThrTrp: 0.631 ± 0.035
1.758ThrTyr: 1.758 ± 0.062
0.0ThrXaa: 0.0 ± 0.0
Val
9.663ValAla: 9.663 ± 0.143
1.466ValCys: 1.466 ± 0.061
5.323ValAsp: 5.323 ± 0.09
4.829ValGlu: 4.829 ± 0.107
2.62ValPhe: 2.62 ± 0.071
5.664ValGly: 5.664 ± 0.095
1.322ValHis: 1.322 ± 0.052
3.974ValIle: 3.974 ± 0.086
2.687ValLys: 2.687 ± 0.078
6.986ValLeu: 6.986 ± 0.124
1.857ValMet: 1.857 ± 0.061
2.353ValAsn: 2.353 ± 0.074
3.929ValPro: 3.929 ± 0.087
2.27ValGln: 2.27 ± 0.054
4.216ValArg: 4.216 ± 0.096
5.117ValSer: 5.117 ± 0.088
4.809ValThr: 4.809 ± 0.117
6.744ValVal: 6.744 ± 0.133
0.799ValTrp: 0.799 ± 0.04
1.871ValTyr: 1.871 ± 0.053
0.0ValXaa: 0.0 ± 0.0
Trp
1.104TrpAla: 1.104 ± 0.048
0.233TrpCys: 0.233 ± 0.021
0.751TrpAsp: 0.751 ± 0.034
0.677TrpGlu: 0.677 ± 0.035
0.426TrpPhe: 0.426 ± 0.026
0.977TrpGly: 0.977 ± 0.046
0.24TrpHis: 0.24 ± 0.021
0.564TrpIle: 0.564 ± 0.034
0.387TrpLys: 0.387 ± 0.025
1.2TrpLeu: 1.2 ± 0.049
0.337TrpMet: 0.337 ± 0.026
0.405TrpAsn: 0.405 ± 0.029
0.519TrpPro: 0.519 ± 0.035
0.511TrpGln: 0.511 ± 0.034
0.737TrpArg: 0.737 ± 0.038
0.652TrpSer: 0.652 ± 0.035
0.461TrpThr: 0.461 ± 0.031
0.823TrpVal: 0.823 ± 0.039
0.168TrpTrp: 0.168 ± 0.016
0.415TrpTyr: 0.415 ± 0.048
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.569TyrAla: 2.569 ± 0.07
0.382TyrCys: 0.382 ± 0.029
1.952TyrAsp: 1.952 ± 0.072
1.853TyrGlu: 1.853 ± 0.072
0.974TyrPhe: 0.974 ± 0.042
2.491TyrGly: 2.491 ± 0.067
0.585TyrHis: 0.585 ± 0.03
1.263TyrIle: 1.263 ± 0.05
0.896TyrLys: 0.896 ± 0.043
2.991TyrLeu: 2.991 ± 0.086
0.59TyrMet: 0.59 ± 0.032
0.903TyrAsn: 0.903 ± 0.043
1.212TyrPro: 1.212 ± 0.047
0.998TyrGln: 0.998 ± 0.044
1.701TyrArg: 1.701 ± 0.059
1.542TyrSer: 1.542 ± 0.055
1.567TyrThr: 1.567 ± 0.053
2.127TyrVal: 2.127 ± 0.073
0.33TyrTrp: 0.33 ± 0.024
0.968TyrTyr: 0.968 ± 0.061
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1631 proteins (565989 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski