Amino acid dipepetide frequency for SAR202 cluster bacterium AD-802-L14_MRT_200m

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.552AlaAla: 8.552 ± 0.251
0.855AlaCys: 0.855 ± 0.061
4.936AlaAsp: 4.936 ± 0.135
5.576AlaGlu: 5.576 ± 0.164
3.151AlaPhe: 3.151 ± 0.127
7.469AlaGly: 7.469 ± 0.196
1.731AlaHis: 1.731 ± 0.095
6.464AlaIle: 6.464 ± 0.181
3.413AlaLys: 3.413 ± 0.119
8.141AlaLeu: 8.141 ± 0.208
2.532AlaMet: 2.532 ± 0.106
3.064AlaAsn: 3.064 ± 0.11
3.093AlaPro: 3.093 ± 0.127
2.823AlaGln: 2.823 ± 0.108
4.866AlaArg: 4.866 ± 0.15
5.767AlaSer: 5.767 ± 0.151
4.94AlaThr: 4.94 ± 0.146
6.775AlaVal: 6.775 ± 0.173
1.042AlaTrp: 1.042 ± 0.067
2.238AlaTyr: 2.238 ± 0.103
0.0AlaXaa: 0.0 ± 0.0
Cys
0.693CysAla: 0.693 ± 0.053
0.083CysCys: 0.083 ± 0.022
0.502CysAsp: 0.502 ± 0.049
0.552CysGlu: 0.552 ± 0.051
0.266CysPhe: 0.266 ± 0.029
0.801CysGly: 0.801 ± 0.058
0.278CysHis: 0.278 ± 0.035
0.448CysIle: 0.448 ± 0.044
0.266CysLys: 0.266 ± 0.034
0.573CysLeu: 0.573 ± 0.053
0.158CysMet: 0.158 ± 0.029
0.311CysAsn: 0.311 ± 0.035
0.403CysPro: 0.403 ± 0.047
0.262CysGln: 0.262 ± 0.034
0.34CysArg: 0.34 ± 0.038
0.515CysSer: 0.515 ± 0.053
0.469CysThr: 0.469 ± 0.048
0.573CysVal: 0.573 ± 0.046
0.091CysTrp: 0.091 ± 0.019
0.228CysTyr: 0.228 ± 0.031
0.0CysXaa: 0.0 ± 0.0
Asp
5.144AspAla: 5.144 ± 0.13
0.386AspCys: 0.386 ± 0.04
3.624AspAsp: 3.624 ± 0.128
4.43AspGlu: 4.43 ± 0.157
2.267AspPhe: 2.267 ± 0.107
5.09AspGly: 5.09 ± 0.188
1.59AspHis: 1.59 ± 0.071
4.168AspIle: 4.168 ± 0.114
1.955AspLys: 1.955 ± 0.094
5.758AspLeu: 5.758 ± 0.171
1.632AspMet: 1.632 ± 0.08
2.063AspAsn: 2.063 ± 0.103
3.417AspPro: 3.417 ± 0.12
2.167AspGln: 2.167 ± 0.092
3.695AspArg: 3.695 ± 0.112
3.72AspSer: 3.72 ± 0.123
3.076AspThr: 3.076 ± 0.118
4.675AspVal: 4.675 ± 0.142
0.909AspTrp: 0.909 ± 0.071
1.723AspTyr: 1.723 ± 0.084
0.0AspXaa: 0.0 ± 0.0
Glu
5.347GluAla: 5.347 ± 0.178
0.432GluCys: 0.432 ± 0.044
3.458GluAsp: 3.458 ± 0.126
4.123GluGlu: 4.123 ± 0.176
2.599GluPhe: 2.599 ± 0.116
4.235GluGly: 4.235 ± 0.14
1.482GluHis: 1.482 ± 0.1
4.895GluIle: 4.895 ± 0.144
2.827GluLys: 2.827 ± 0.134
5.991GluLeu: 5.991 ± 0.18
1.98GluMet: 1.98 ± 0.083
2.931GluAsn: 2.931 ± 0.117
2.64GluPro: 2.64 ± 0.11
2.425GluGln: 2.425 ± 0.112
3.84GluArg: 3.84 ± 0.149
4.48GluSer: 4.48 ± 0.137
3.508GluThr: 3.508 ± 0.124
4.87GluVal: 4.87 ± 0.155
1.046GluTrp: 1.046 ± 0.068
1.789GluTyr: 1.789 ± 0.086
0.0GluXaa: 0.0 ± 0.0
Phe
3.284PheAla: 3.284 ± 0.11
0.328PheCys: 0.328 ± 0.037
2.823PheAsp: 2.823 ± 0.106
2.665PheGlu: 2.665 ± 0.117
1.482PhePhe: 1.482 ± 0.089
3.716PheGly: 3.716 ± 0.113
0.706PheHis: 0.706 ± 0.048
2.317PheIle: 2.317 ± 0.098
1.503PheLys: 1.503 ± 0.079
2.989PheLeu: 2.989 ± 0.129
0.847PheMet: 0.847 ± 0.055
1.573PheAsn: 1.573 ± 0.081
1.648PhePro: 1.648 ± 0.106
1.138PheGln: 1.138 ± 0.067
1.81PheArg: 1.81 ± 0.08
2.69PheSer: 2.69 ± 0.11
2.109PheThr: 2.109 ± 0.095
2.595PheVal: 2.595 ± 0.111
0.598PheTrp: 0.598 ± 0.057
0.967PheTyr: 0.967 ± 0.065
0.0PheXaa: 0.0 ± 0.0
Gly
6.759GlyAla: 6.759 ± 0.188
0.714GlyCys: 0.714 ± 0.058
4.583GlyAsp: 4.583 ± 0.146
4.953GlyGlu: 4.953 ± 0.131
3.458GlyPhe: 3.458 ± 0.116
6.771GlyGly: 6.771 ± 0.188
2.038GlyHis: 2.038 ± 0.108
6.41GlyIle: 6.41 ± 0.176
3.716GlyLys: 3.716 ± 0.13
7.701GlyLeu: 7.701 ± 0.2
2.549GlyMet: 2.549 ± 0.113
3.014GlyAsn: 3.014 ± 0.12
3.521GlyPro: 3.521 ± 0.167
2.616GlyGln: 2.616 ± 0.112
4.26GlyArg: 4.26 ± 0.138
5.684GlySer: 5.684 ± 0.158
4.745GlyThr: 4.745 ± 0.143
6.286GlyVal: 6.286 ± 0.165
1.528GlyTrp: 1.528 ± 0.095
2.537GlyTyr: 2.537 ± 0.11
0.0GlyXaa: 0.0 ± 0.0
His
1.619HisAla: 1.619 ± 0.081
0.203HisCys: 0.203 ± 0.029
1.329HisAsp: 1.329 ± 0.065
1.221HisGlu: 1.221 ± 0.072
0.913HisPhe: 0.913 ± 0.06
2.034HisGly: 2.034 ± 0.106
0.594HisHis: 0.594 ± 0.048
1.47HisIle: 1.47 ± 0.086
0.673HisLys: 0.673 ± 0.055
1.769HisLeu: 1.769 ± 0.084
0.581HisMet: 0.581 ± 0.048
0.905HisAsn: 0.905 ± 0.068
1.412HisPro: 1.412 ± 0.073
0.71HisGln: 0.71 ± 0.049
1.287HisArg: 1.287 ± 0.08
1.362HisSer: 1.362 ± 0.076
1.096HisThr: 1.096 ± 0.068
1.681HisVal: 1.681 ± 0.086
0.353HisTrp: 0.353 ± 0.043
0.61HisTyr: 0.61 ± 0.046
0.0HisXaa: 0.0 ± 0.0
Ile
6.871IleAla: 6.871 ± 0.192
0.482IleCys: 0.482 ± 0.043
4.949IleAsp: 4.949 ± 0.139
4.866IleGlu: 4.866 ± 0.156
2.404IlePhe: 2.404 ± 0.117
6.248IleGly: 6.248 ± 0.185
1.241IleHis: 1.241 ± 0.067
3.5IleIle: 3.5 ± 0.131
2.645IleLys: 2.645 ± 0.106
5.119IleLeu: 5.119 ± 0.145
1.378IleMet: 1.378 ± 0.062
2.674IleAsn: 2.674 ± 0.102
3.255IlePro: 3.255 ± 0.118
1.798IleGln: 1.798 ± 0.084
3.678IleArg: 3.678 ± 0.112
4.812IleSer: 4.812 ± 0.145
4.056IleThr: 4.056 ± 0.128
4.837IleVal: 4.837 ± 0.154
0.851IleTrp: 0.851 ± 0.055
1.503IleTyr: 1.503 ± 0.078
0.0IleXaa: 0.0 ± 0.0
Lys
3.599LysAla: 3.599 ± 0.123
0.257LysCys: 0.257 ± 0.033
2.076LysAsp: 2.076 ± 0.083
2.288LysGlu: 2.288 ± 0.124
1.461LysPhe: 1.461 ± 0.082
2.69LysGly: 2.69 ± 0.107
0.826LysHis: 0.826 ± 0.06
2.806LysIle: 2.806 ± 0.121
1.93LysLys: 1.93 ± 0.091
3.678LysLeu: 3.678 ± 0.131
1.121LysMet: 1.121 ± 0.064
1.789LysAsn: 1.789 ± 0.102
1.96LysPro: 1.96 ± 0.092
1.358LysGln: 1.358 ± 0.083
2.491LysArg: 2.491 ± 0.109
3.039LysSer: 3.039 ± 0.114
2.732LysThr: 2.732 ± 0.112
2.819LysVal: 2.819 ± 0.119
0.614LysTrp: 0.614 ± 0.052
1.096LysTyr: 1.096 ± 0.07
0.0LysXaa: 0.0 ± 0.0
Leu
8.195LeuAla: 8.195 ± 0.217
0.673LeuCys: 0.673 ± 0.056
5.426LeuAsp: 5.426 ± 0.142
6.14LeuGlu: 6.14 ± 0.192
3.188LeuPhe: 3.188 ± 0.132
7.797LeuGly: 7.797 ± 0.206
1.74LeuHis: 1.74 ± 0.084
5.953LeuIle: 5.953 ± 0.194
4.04LeuLys: 4.04 ± 0.143
7.718LeuLeu: 7.718 ± 0.245
2.279LeuMet: 2.279 ± 0.115
3.305LeuAsn: 3.305 ± 0.121
3.923LeuPro: 3.923 ± 0.131
2.512LeuGln: 2.512 ± 0.089
5.044LeuArg: 5.044 ± 0.145
6.14LeuSer: 6.14 ± 0.178
5.14LeuThr: 5.14 ± 0.136
6.232LeuVal: 6.232 ± 0.191
1.055LeuTrp: 1.055 ± 0.066
1.648LeuTyr: 1.648 ± 0.086
0.0LeuXaa: 0.0 ± 0.0
Met
2.649MetAla: 2.649 ± 0.109
0.22MetCys: 0.22 ± 0.028
1.333MetAsp: 1.333 ± 0.08
1.358MetGlu: 1.358 ± 0.083
0.988MetPhe: 0.988 ± 0.063
2.051MetGly: 2.051 ± 0.09
0.54MetHis: 0.54 ± 0.05
1.69MetIle: 1.69 ± 0.083
1.362MetLys: 1.362 ± 0.07
2.155MetLeu: 2.155 ± 0.102
0.818MetMet: 0.818 ± 0.073
1.183MetAsn: 1.183 ± 0.072
1.598MetPro: 1.598 ± 0.075
0.764MetGln: 0.764 ± 0.052
1.544MetArg: 1.544 ± 0.08
2.026MetSer: 2.026 ± 0.094
1.877MetThr: 1.877 ± 0.096
1.76MetVal: 1.76 ± 0.074
0.399MetTrp: 0.399 ± 0.037
0.531MetTyr: 0.531 ± 0.044
0.0MetXaa: 0.0 ± 0.0
Asn
3.471AsnAla: 3.471 ± 0.139
0.34AsnCys: 0.34 ± 0.04
2.055AsnAsp: 2.055 ± 0.092
2.375AsnGlu: 2.375 ± 0.101
1.573AsnPhe: 1.573 ± 0.085
2.964AsnGly: 2.964 ± 0.118
0.847AsnHis: 0.847 ± 0.061
2.483AsnIle: 2.483 ± 0.097
1.366AsnLys: 1.366 ± 0.088
3.579AsnLeu: 3.579 ± 0.129
1.146AsnMet: 1.146 ± 0.07
1.536AsnAsn: 1.536 ± 0.099
2.395AsnPro: 2.395 ± 0.109
1.295AsnGln: 1.295 ± 0.068
2.325AsnArg: 2.325 ± 0.101
2.433AsnSer: 2.433 ± 0.105
2.084AsnThr: 2.084 ± 0.088
2.74AsnVal: 2.74 ± 0.103
0.656AsnTrp: 0.656 ± 0.055
1.142AsnTyr: 1.142 ± 0.065
0.0AsnXaa: 0.0 ± 0.0
Pro
3.35ProAla: 3.35 ± 0.119
0.232ProCys: 0.232 ± 0.03
3.716ProAsp: 3.716 ± 0.126
3.608ProGlu: 3.608 ± 0.129
1.839ProPhe: 1.839 ± 0.09
4.002ProGly: 4.002 ± 0.146
1.15ProHis: 1.15 ± 0.064
2.96ProIle: 2.96 ± 0.117
1.706ProLys: 1.706 ± 0.078
3.749ProLeu: 3.749 ± 0.132
1.192ProMet: 1.192 ± 0.081
1.897ProAsn: 1.897 ± 0.095
1.906ProPro: 1.906 ± 0.098
1.349ProGln: 1.349 ± 0.07
2.009ProArg: 2.009 ± 0.095
3.014ProSer: 3.014 ± 0.098
2.74ProThr: 2.74 ± 0.105
3.695ProVal: 3.695 ± 0.114
0.764ProTrp: 0.764 ± 0.059
1.221ProTyr: 1.221 ± 0.066
0.0ProXaa: 0.0 ± 0.0
Gln
2.96GlnAla: 2.96 ± 0.103
0.228GlnCys: 0.228 ± 0.027
1.515GlnAsp: 1.515 ± 0.088
1.818GlnGlu: 1.818 ± 0.097
1.113GlnPhe: 1.113 ± 0.069
2.321GlnGly: 2.321 ± 0.1
0.764GlnHis: 0.764 ± 0.056
2.304GlnIle: 2.304 ± 0.098
1.216GlnLys: 1.216 ± 0.072
2.968GlnLeu: 2.968 ± 0.119
0.996GlnMet: 0.996 ± 0.081
1.158GlnAsn: 1.158 ± 0.073
1.42GlnPro: 1.42 ± 0.076
1.175GlnGln: 1.175 ± 0.072
2.113GlnArg: 2.113 ± 0.102
2.3GlnSer: 2.3 ± 0.107
1.91GlnThr: 1.91 ± 0.089
2.279GlnVal: 2.279 ± 0.08
0.411GlnTrp: 0.411 ± 0.042
0.776GlnTyr: 0.776 ± 0.056
0.0GlnXaa: 0.0 ± 0.0
Arg
4.392ArgAla: 4.392 ± 0.143
0.407ArgCys: 0.407 ± 0.039
3.193ArgAsp: 3.193 ± 0.122
3.612ArgGlu: 3.612 ± 0.151
2.246ArgPhe: 2.246 ± 0.113
4.048ArgGly: 4.048 ± 0.126
1.125ArgHis: 1.125 ± 0.073
3.682ArgIle: 3.682 ± 0.122
2.395ArgLys: 2.395 ± 0.116
5.148ArgLeu: 5.148 ± 0.167
1.441ArgMet: 1.441 ± 0.066
2.196ArgAsn: 2.196 ± 0.101
2.408ArgPro: 2.408 ± 0.094
2.063ArgGln: 2.063 ± 0.094
3.658ArgArg: 3.658 ± 0.157
3.832ArgSer: 3.832 ± 0.125
2.86ArgThr: 2.86 ± 0.112
4.43ArgVal: 4.43 ± 0.142
1.021ArgTrp: 1.021 ± 0.065
1.594ArgTyr: 1.594 ± 0.082
0.0ArgXaa: 0.0 ± 0.0
Ser
5.434SerAla: 5.434 ± 0.157
0.482SerCys: 0.482 ± 0.05
4.625SerAsp: 4.625 ± 0.147
4.484SerGlu: 4.484 ± 0.14
2.354SerPhe: 2.354 ± 0.112
6.427SerGly: 6.427 ± 0.16
1.445SerHis: 1.445 ± 0.08
4.484SerIle: 4.484 ± 0.14
2.96SerLys: 2.96 ± 0.117
5.945SerLeu: 5.945 ± 0.179
1.831SerMet: 1.831 ± 0.081
2.699SerAsn: 2.699 ± 0.11
2.815SerPro: 2.815 ± 0.112
2.155SerGln: 2.155 ± 0.102
3.645SerArg: 3.645 ± 0.135
4.662SerSer: 4.662 ± 0.149
3.944SerThr: 3.944 ± 0.121
4.754SerVal: 4.754 ± 0.154
1.005SerTrp: 1.005 ± 0.077
1.611SerTyr: 1.611 ± 0.07
0.0SerXaa: 0.0 ± 0.0
Thr
4.928ThrAla: 4.928 ± 0.149
0.419ThrCys: 0.419 ± 0.036
3.45ThrAsp: 3.45 ± 0.118
3.176ThrGlu: 3.176 ± 0.117
2.059ThrPhe: 2.059 ± 0.088
5.464ThrGly: 5.464 ± 0.166
1.399ThrHis: 1.399 ± 0.089
3.525ThrIle: 3.525 ± 0.108
2.146ThrLys: 2.146 ± 0.099
5.065ThrLeu: 5.065 ± 0.148
1.432ThrMet: 1.432 ± 0.084
2.059ThrAsn: 2.059 ± 0.087
3.093ThrPro: 3.093 ± 0.102
1.594ThrGln: 1.594 ± 0.073
2.989ThrArg: 2.989 ± 0.125
3.873ThrSer: 3.873 ± 0.126
3.193ThrThr: 3.193 ± 0.12
4.745ThrVal: 4.745 ± 0.132
0.743ThrTrp: 0.743 ± 0.06
1.532ThrTyr: 1.532 ± 0.085
0.0ThrXaa: 0.0 ± 0.0
Val
6.867ValAla: 6.867 ± 0.172
0.702ValCys: 0.702 ± 0.061
5.206ValAsp: 5.206 ± 0.16
5.036ValGlu: 5.036 ± 0.169
2.856ValPhe: 2.856 ± 0.114
6.14ValGly: 6.14 ± 0.172
1.49ValHis: 1.49 ± 0.07
5.372ValIle: 5.372 ± 0.173
2.848ValLys: 2.848 ± 0.119
6.522ValLeu: 6.522 ± 0.172
1.885ValMet: 1.885 ± 0.083
2.973ValAsn: 2.973 ± 0.107
3.396ValPro: 3.396 ± 0.119
2.109ValGln: 2.109 ± 0.096
3.716ValArg: 3.716 ± 0.123
4.708ValSer: 4.708 ± 0.138
4.26ValThr: 4.26 ± 0.152
6.032ValVal: 6.032 ± 0.18
0.868ValTrp: 0.868 ± 0.069
1.744ValTyr: 1.744 ± 0.082
0.0ValXaa: 0.0 ± 0.0
Trp
1.129TrpAla: 1.129 ± 0.074
0.137TrpCys: 0.137 ± 0.022
1.017TrpAsp: 1.017 ± 0.062
0.756TrpGlu: 0.756 ± 0.071
0.527TrpPhe: 0.527 ± 0.052
1.15TrpGly: 1.15 ± 0.07
0.332TrpHis: 0.332 ± 0.04
0.934TrpIle: 0.934 ± 0.07
0.627TrpLys: 0.627 ± 0.055
1.283TrpLeu: 1.283 ± 0.088
0.469TrpMet: 0.469 ± 0.041
0.656TrpAsn: 0.656 ± 0.049
0.619TrpPro: 0.619 ± 0.056
0.531TrpGln: 0.531 ± 0.051
0.93TrpArg: 0.93 ± 0.06
1.059TrpSer: 1.059 ± 0.081
0.805TrpThr: 0.805 ± 0.063
1.03TrpVal: 1.03 ± 0.064
0.407TrpTrp: 0.407 ± 0.047
0.353TrpTyr: 0.353 ± 0.041
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.184TyrAla: 2.184 ± 0.081
0.232TyrCys: 0.232 ± 0.029
1.673TyrAsp: 1.673 ± 0.1
1.864TyrGlu: 1.864 ± 0.085
1.042TyrPhe: 1.042 ± 0.062
2.425TyrGly: 2.425 ± 0.094
0.502TyrHis: 0.502 ± 0.046
1.299TyrIle: 1.299 ± 0.079
1.042TyrLys: 1.042 ± 0.079
2.296TyrLeu: 2.296 ± 0.107
0.573TyrMet: 0.573 ± 0.059
0.818TyrAsn: 0.818 ± 0.066
1.179TyrPro: 1.179 ± 0.067
0.905TyrGln: 0.905 ± 0.066
1.511TyrArg: 1.511 ± 0.088
1.644TyrSer: 1.644 ± 0.079
1.341TyrThr: 1.341 ± 0.062
1.922TyrVal: 1.922 ± 0.093
0.39TyrTrp: 0.39 ± 0.042
0.764TyrTyr: 0.764 ± 0.061
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 819 proteins (240872 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski