Amino acid dipepetide frequency for Coccomyxa subellipsoidea (strain C-169) (Green microalga)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	21.626AlaAla: 21.626 ± 0.209	1.759AlaCys: 1.759 ± 0.023	6.112AlaAsp: 6.112 ± 0.048	7.776AlaGlu: 7.776 ± 0.075	3.53AlaPhe: 3.53 ± 0.031	9.204AlaGly: 9.204 ± 0.064	2.405AlaHis: 2.405 ± 0.03	3.747AlaIle: 3.747 ± 0.038	4.566AlaLys: 4.566 ± 0.044	11.43AlaLeu: 11.43 ± 0.094	2.501AlaMet: 2.501 ± 0.026	2.762AlaAsn: 2.762 ± 0.029	6.955AlaPro: 6.955 ± 0.087	5.281AlaGln: 5.281 ± 0.057	6.719AlaArg: 6.719 ± 0.063	8.66AlaSer: 8.66 ± 0.071	5.774AlaThr: 5.774 ± 0.126	8.112AlaVal: 8.112 ± 0.059	1.402AlaTrp: 1.402 ± 0.022	2.174AlaTyr: 2.174 ± 0.028	0.0AlaXaa: 0.0 ± 0.0
Cys	1.516CysAla: 1.516 ± 0.021	0.402CysCys: 0.402 ± 0.01	0.642CysAsp: 0.642 ± 0.015	0.679CysGlu: 0.679 ± 0.013	0.589CysPhe: 0.589 ± 0.012	1.19CysGly: 1.19 ± 0.02	0.395CysHis: 0.395 ± 0.01	0.688CysIle: 0.688 ± 0.013	0.622CysLys: 0.622 ± 0.014	1.57CysLeu: 1.57 ± 0.023	0.416CysMet: 0.416 ± 0.011	0.484CysAsn: 0.484 ± 0.011	0.848CysPro: 0.848 ± 0.016	0.592CysGln: 0.592 ± 0.013	0.97CysArg: 0.97 ± 0.019	1.263CysSer: 1.263 ± 0.022	0.9CysThr: 0.9 ± 0.016	0.903CysVal: 0.903 ± 0.015	0.24CysTrp: 0.24 ± 0.008	0.345CysTyr: 0.345 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	6.067AspAla: 6.067 ± 0.047	0.729AspCys: 0.729 ± 0.013	3.03AspAsp: 3.03 ± 0.038	3.458AspGlu: 3.458 ± 0.041	1.902AspPhe: 1.902 ± 0.027	4.086AspGly: 4.086 ± 0.039	0.932AspHis: 0.932 ± 0.015	2.327AspIle: 2.327 ± 0.026	2.057AspLys: 2.057 ± 0.028	4.842AspLeu: 4.842 ± 0.033	1.285AspMet: 1.285 ± 0.018	1.393AspAsn: 1.393 ± 0.021	2.827AspPro: 2.827 ± 0.026	1.591AspGln: 1.591 ± 0.021	2.8AspArg: 2.8 ± 0.035	3.551AspSer: 3.551 ± 0.032	2.502AspThr: 2.502 ± 0.033	3.712AspVal: 3.712 ± 0.034	0.788AspTrp: 0.788 ± 0.016	1.229AspTyr: 1.229 ± 0.018	0.0AspXaa: 0.0 ± 0.0
Glu	8.319GluAla: 8.319 ± 0.07	0.708GluCys: 0.708 ± 0.013	3.685GluAsp: 3.685 ± 0.037	5.62GluGlu: 5.62 ± 0.062	1.555GluPhe: 1.555 ± 0.021	4.782GluGly: 4.782 ± 0.039	1.368GluHis: 1.368 ± 0.019	2.043GluIle: 2.043 ± 0.024	2.714GluLys: 2.714 ± 0.037	5.794GluLeu: 5.794 ± 0.048	1.35GluMet: 1.35 ± 0.021	1.426GluAsn: 1.426 ± 0.019	2.746GluPro: 2.746 ± 0.035	2.975GluGln: 2.975 ± 0.03	4.314GluArg: 4.314 ± 0.043	3.169GluSer: 3.169 ± 0.03	2.515GluThr: 2.515 ± 0.037	4.112GluVal: 4.112 ± 0.035	0.75GluTrp: 0.75 ± 0.013	1.276GluTyr: 1.276 ± 0.018	0.0GluXaa: 0.0 ± 0.0
Phe	3.107PheAla: 3.107 ± 0.031	0.618PheCys: 0.618 ± 0.013	1.748PheAsp: 1.748 ± 0.025	1.779PheGlu: 1.779 ± 0.026	1.314PhePhe: 1.314 ± 0.023	2.753PheGly: 2.753 ± 0.03	0.725PheHis: 0.725 ± 0.015	1.195PheIle: 1.195 ± 0.019	1.323PheLys: 1.323 ± 0.02	3.234PheLeu: 3.234 ± 0.032	0.767PheMet: 0.767 ± 0.013	1.098PheAsn: 1.098 ± 0.02	1.589PhePro: 1.589 ± 0.022	1.334PheGln: 1.334 ± 0.018	1.722PheArg: 1.722 ± 0.022	2.419PheSer: 2.419 ± 0.027	1.954PheThr: 1.954 ± 0.131	2.293PheVal: 2.293 ± 0.026	0.516PheTrp: 0.516 ± 0.011	0.919PheTyr: 0.919 ± 0.016	0.0PheXaa: 0.0 ± 0.0
Gly	8.605GlyAla: 8.605 ± 0.131	1.228GlyCys: 1.228 ± 0.019	3.946GlyAsp: 3.946 ± 0.044	4.035GlyGlu: 4.035 ± 0.038	2.893GlyPhe: 2.893 ± 0.139	7.584GlyGly: 7.584 ± 0.08	1.798GlyHis: 1.798 ± 0.024	3.011GlyIle: 3.011 ± 0.033	3.406GlyLys: 3.406 ± 0.034	6.925GlyLeu: 6.925 ± 0.045	1.82GlyMet: 1.82 ± 0.025	2.421GlyAsn: 2.421 ± 0.034	4.074GlyPro: 4.074 ± 0.037	3.272GlyGln: 3.272 ± 0.032	5.238GlyArg: 5.238 ± 0.046	6.523GlySer: 6.523 ± 0.062	4.163GlyThr: 4.163 ± 0.039	5.077GlyVal: 5.077 ± 0.046	1.092GlyTrp: 1.092 ± 0.017	1.88GlyTyr: 1.88 ± 0.027	0.0GlyXaa: 0.0 ± 0.0
His	2.559HisAla: 2.559 ± 0.027	0.439HisCys: 0.439 ± 0.011	1.012HisAsp: 1.012 ± 0.017	1.085HisGlu: 1.085 ± 0.016	0.848HisPhe: 0.848 ± 0.016	1.661HisGly: 1.661 ± 0.021	0.641HisHis: 0.641 ± 0.013	0.959HisIle: 0.959 ± 0.017	0.895HisLys: 0.895 ± 0.016	2.316HisLeu: 2.316 ± 0.027	0.623HisMet: 0.623 ± 0.013	0.674HisAsn: 0.674 ± 0.013	1.447HisPro: 1.447 ± 0.02	0.873HisGln: 0.873 ± 0.016	1.461HisArg: 1.461 ± 0.019	1.701HisSer: 1.701 ± 0.021	1.149HisThr: 1.149 ± 0.016	1.492HisVal: 1.492 ± 0.02	0.374HisTrp: 0.374 ± 0.01	0.569HisTyr: 0.569 ± 0.013	0.0HisXaa: 0.0 ± 0.0
Ile	3.847IleAla: 3.847 ± 0.033	0.679IleCys: 0.679 ± 0.014	1.93IleAsp: 1.93 ± 0.023	1.974IleGlu: 1.974 ± 0.023	1.427IlePhe: 1.427 ± 0.019	2.626IleGly: 2.626 ± 0.032	0.762IleHis: 0.762 ± 0.012	1.828IleIle: 1.828 ± 0.058	1.629IleLys: 1.629 ± 0.024	3.416IleLeu: 3.416 ± 0.035	0.87IleMet: 0.87 ± 0.015	1.244IleAsn: 1.244 ± 0.02	1.982IlePro: 1.982 ± 0.026	1.342IleGln: 1.342 ± 0.019	1.965IleArg: 1.965 ± 0.023	2.658IleSer: 2.658 ± 0.025	2.08IleThr: 2.08 ± 0.023	2.678IleVal: 2.678 ± 0.026	0.485IleTrp: 0.485 ± 0.013	0.912IleTyr: 0.912 ± 0.016	0.0IleXaa: 0.0 ± 0.0
Lys	5.007LysAla: 5.007 ± 0.049	0.477LysCys: 0.477 ± 0.012	2.258LysAsp: 2.258 ± 0.031	3.111LysGlu: 3.111 ± 0.04	1.145LysPhe: 1.145 ± 0.017	3.236LysGly: 3.236 ± 0.036	0.96LysHis: 0.96 ± 0.014	1.426LysIle: 1.426 ± 0.021	2.542LysLys: 2.542 ± 0.04	3.96LysLeu: 3.96 ± 0.036	0.899LysMet: 0.899 ± 0.017	1.085LysAsn: 1.085 ± 0.016	2.185LysPro: 2.185 ± 0.027	1.924LysGln: 1.924 ± 0.024	2.912LysArg: 2.912 ± 0.03	2.303LysSer: 2.303 ± 0.024	1.931LysThr: 1.931 ± 0.025	2.796LysVal: 2.796 ± 0.031	0.544LysTrp: 0.544 ± 0.013	1.0LysTyr: 1.0 ± 0.018	0.0LysXaa: 0.0 ± 0.0
Leu	10.887LeuAla: 10.887 ± 0.079	1.5LeuCys: 1.5 ± 0.022	5.074LeuAsp: 5.074 ± 0.043	6.114LeuGlu: 6.114 ± 0.049	2.93LeuPhe: 2.93 ± 0.031	6.797LeuGly: 6.797 ± 0.05	2.518LeuHis: 2.518 ± 0.026	3.138LeuIle: 3.138 ± 0.033	4.065LeuLys: 4.065 ± 0.04	10.485LeuLeu: 10.485 ± 0.09	2.077LeuMet: 2.077 ± 0.025	2.539LeuAsn: 2.539 ± 0.028	6.298LeuPro: 6.298 ± 0.051	5.548LeuGln: 5.548 ± 0.052	6.674LeuArg: 6.674 ± 0.055	6.712LeuSer: 6.712 ± 0.048	4.78LeuThr: 4.78 ± 0.038	5.919LeuVal: 5.919 ± 0.045	1.242LeuTrp: 1.242 ± 0.019	2.091LeuTyr: 2.091 ± 0.023	0.0LeuXaa: 0.0 ± 0.0
Met	2.667MetAla: 2.667 ± 0.029	0.332MetCys: 0.332 ± 0.01	1.195MetAsp: 1.195 ± 0.017	1.433MetGlu: 1.433 ± 0.018	0.619MetPhe: 0.619 ± 0.015	1.718MetGly: 1.718 ± 0.024	0.659MetHis: 0.659 ± 0.014	0.64MetIle: 0.64 ± 0.015	0.83MetLys: 0.83 ± 0.017	2.318MetLeu: 2.318 ± 0.023	0.53MetMet: 0.53 ± 0.014	0.549MetAsn: 0.549 ± 0.012	1.332MetPro: 1.332 ± 0.02	1.322MetGln: 1.322 ± 0.018	1.565MetArg: 1.565 ± 0.02	1.494MetSer: 1.494 ± 0.021	1.067MetThr: 1.067 ± 0.016	1.355MetVal: 1.355 ± 0.017	0.277MetTrp: 0.277 ± 0.008	0.494MetTyr: 0.494 ± 0.012	0.0MetXaa: 0.0 ± 0.0
Asn	3.014AsnAla: 3.014 ± 0.032	0.425AsnCys: 0.425 ± 0.011	1.241AsnAsp: 1.241 ± 0.019	1.37AsnGlu: 1.37 ± 0.018	1.094AsnPhe: 1.094 ± 0.018	2.605AsnGly: 2.605 ± 0.041	0.536AsnHis: 0.536 ± 0.012	1.305AsnIle: 1.305 ± 0.018	1.159AsnLys: 1.159 ± 0.019	2.683AsnLeu: 2.683 ± 0.032	0.668AsnMet: 0.668 ± 0.014	1.122AsnAsn: 1.122 ± 0.072	1.669AsnPro: 1.669 ± 0.023	0.926AsnGln: 0.926 ± 0.016	1.47AsnArg: 1.47 ± 0.021	1.924AsnSer: 1.924 ± 0.022	1.437AsnThr: 1.437 ± 0.022	1.938AsnVal: 1.938 ± 0.025	0.399AsnTrp: 0.399 ± 0.011	0.713AsnTyr: 0.713 ± 0.014	0.0AsnXaa: 0.0 ± 0.0
Pro	7.797ProAla: 7.797 ± 0.089	0.726ProCys: 0.726 ± 0.014	3.069ProAsp: 3.069 ± 0.029	3.76ProGlu: 3.76 ± 0.038	1.858ProPhe: 1.858 ± 0.024	4.822ProGly: 4.822 ± 0.044	1.239ProHis: 1.239 ± 0.017	1.814ProIle: 1.814 ± 0.023	2.184ProLys: 2.184 ± 0.027	5.143ProLeu: 5.143 ± 0.042	1.097ProMet: 1.097 ± 0.017	1.499ProAsn: 1.499 ± 0.023	5.066ProPro: 5.066 ± 0.095	2.69ProGln: 2.69 ± 0.036	3.146ProArg: 3.146 ± 0.034	5.024ProSer: 5.024 ± 0.058	2.832ProThr: 2.832 ± 0.033	3.763ProVal: 3.763 ± 0.038	0.727ProTrp: 0.727 ± 0.013	1.149ProTyr: 1.149 ± 0.018	0.0ProXaa: 0.0 ± 0.0
Gln	5.364GlnAla: 5.364 ± 0.052	0.554GlnCys: 0.554 ± 0.013	1.973GlnAsp: 1.973 ± 0.025	2.857GlnGlu: 2.857 ± 0.035	1.095GlnPhe: 1.095 ± 0.018	3.142GlnGly: 3.142 ± 0.028	1.27GlnHis: 1.27 ± 0.021	1.466GlnIle: 1.466 ± 0.021	1.819GlnLys: 1.819 ± 0.025	4.835GlnLeu: 4.835 ± 0.051	1.012GlnMet: 1.012 ± 0.017	1.139GlnAsn: 1.139 ± 0.02	3.273GlnPro: 3.273 ± 0.042	3.684GlnGln: 3.684 ± 0.062	3.481GlnArg: 3.481 ± 0.038	2.684GlnSer: 2.684 ± 0.028	1.862GlnThr: 1.862 ± 0.021	2.691GlnVal: 2.691 ± 0.027	0.592GlnTrp: 0.592 ± 0.013	0.955GlnTyr: 0.955 ± 0.019	0.0GlnXaa: 0.0 ± 0.0
Arg	6.672ArgAla: 6.672 ± 0.061	1.028ArgCys: 1.028 ± 0.017	2.939ArgAsp: 2.939 ± 0.03	3.858ArgGlu: 3.858 ± 0.045	1.898ArgPhe: 1.898 ± 0.022	4.454ArgGly: 4.454 ± 0.044	1.56ArgHis: 1.56 ± 0.02	2.355ArgIle: 2.355 ± 0.022	2.909ArgLys: 2.909 ± 0.032	6.472ArgLeu: 6.472 ± 0.047	1.523ArgMet: 1.523 ± 0.019	1.677ArgAsn: 1.677 ± 0.021	3.541ArgPro: 3.541 ± 0.037	3.136ArgGln: 3.136 ± 0.036	5.055ArgArg: 5.055 ± 0.052	4.526ArgSer: 4.526 ± 0.038	2.939ArgThr: 2.939 ± 0.028	3.721ArgVal: 3.721 ± 0.027	0.944ArgTrp: 0.944 ± 0.016	1.324ArgTyr: 1.324 ± 0.021	0.0ArgXaa: 0.0 ± 0.0
Ser	8.584SerAla: 8.584 ± 0.069	1.155SerCys: 1.155 ± 0.021	3.391SerAsp: 3.391 ± 0.031	3.714SerGlu: 3.714 ± 0.031	2.451SerPhe: 2.451 ± 0.024	6.36SerGly: 6.36 ± 0.05	1.482SerHis: 1.482 ± 0.019	2.6SerIle: 2.6 ± 0.031	2.864SerLys: 2.864 ± 0.031	6.879SerLeu: 6.879 ± 0.047	1.635SerMet: 1.635 ± 0.022	2.046SerAsn: 2.046 ± 0.026	4.436SerPro: 4.436 ± 0.065	2.903SerGln: 2.903 ± 0.031	4.164SerArg: 4.164 ± 0.036	6.622SerSer: 6.622 ± 0.064	3.858SerThr: 3.858 ± 0.051	4.24SerVal: 4.24 ± 0.039	0.969SerTrp: 0.969 ± 0.015	1.511SerTyr: 1.511 ± 0.02	0.0SerXaa: 0.0 ± 0.0
Thr	6.058ThrAla: 6.058 ± 0.051	0.829ThrCys: 0.829 ± 0.018	2.381ThrAsp: 2.381 ± 0.026	2.605ThrGlu: 2.605 ± 0.029	1.77ThrPhe: 1.77 ± 0.025	4.785ThrGly: 4.785 ± 0.381	1.003ThrHis: 1.003 ± 0.015	1.899ThrIle: 1.899 ± 0.027	1.822ThrLys: 1.822 ± 0.025	4.79ThrLeu: 4.79 ± 0.039	0.97ThrMet: 0.97 ± 0.017	1.368ThrAsn: 1.368 ± 0.02	3.448ThrPro: 3.448 ± 0.042	1.829ThrGln: 1.829 ± 0.02	2.52ThrArg: 2.52 ± 0.025	3.747ThrSer: 3.747 ± 0.034	2.467ThrThr: 2.467 ± 0.033	3.48ThrVal: 3.48 ± 0.028	0.699ThrTrp: 0.699 ± 0.016	1.143ThrTyr: 1.143 ± 0.017	0.0ThrXaa: 0.0 ± 0.0
Val	7.441ValAla: 7.441 ± 0.048	1.051ValCys: 1.051 ± 0.018	3.457ValAsp: 3.457 ± 0.033	3.944ValGlu: 3.944 ± 0.031	2.163ValPhe: 2.163 ± 0.026	4.379ValGly: 4.379 ± 0.039	1.642ValHis: 1.642 ± 0.021	2.496ValIle: 2.496 ± 0.03	2.734ValLys: 2.734 ± 0.031	6.799ValLeu: 6.799 ± 0.05	1.457ValMet: 1.457 ± 0.02	1.831ValAsn: 1.831 ± 0.026	3.989ValPro: 3.989 ± 0.034	2.913ValGln: 2.913 ± 0.03	3.959ValArg: 3.959 ± 0.034	4.445ValSer: 4.445 ± 0.037	3.483ValThr: 3.483 ± 0.034	4.629ValVal: 4.629 ± 0.043	0.897ValTrp: 0.897 ± 0.017	1.547ValTyr: 1.547 ± 0.02	0.0ValXaa: 0.0 ± 0.0
Trp	1.329TrpAla: 1.329 ± 0.02	0.219TrpCys: 0.219 ± 0.008	0.786TrpAsp: 0.786 ± 0.014	0.797TrpGlu: 0.797 ± 0.013	0.438TrpPhe: 0.438 ± 0.011	0.976TrpGly: 0.976 ± 0.018	0.383TrpHis: 0.383 ± 0.011	0.433TrpIle: 0.433 ± 0.011	0.569TrpLys: 0.569 ± 0.013	1.378TrpLeu: 1.378 ± 0.022	0.323TrpMet: 0.323 ± 0.009	0.438TrpAsn: 0.438 ± 0.011	0.66TrpPro: 0.66 ± 0.017	0.773TrpGln: 0.773 ± 0.016	1.078TrpArg: 1.078 ± 0.02	0.876TrpSer: 0.876 ± 0.016	0.681TrpThr: 0.681 ± 0.012	0.817TrpVal: 0.817 ± 0.016	0.261TrpTrp: 0.261 ± 0.009	0.343TrpTyr: 0.343 ± 0.011	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.028TyrAla: 2.028 ± 0.024	0.395TyrCys: 0.395 ± 0.01	1.239TyrAsp: 1.239 ± 0.019	1.253TyrGlu: 1.253 ± 0.017	0.89TyrPhe: 0.89 ± 0.015	1.832TyrGly: 1.832 ± 0.03	0.497TyrHis: 0.497 ± 0.012	0.966TyrIle: 0.966 ± 0.016	0.991TyrLys: 0.991 ± 0.016	2.12TyrLeu: 2.12 ± 0.028	0.571TyrMet: 0.571 ± 0.011	0.904TyrAsn: 0.904 ± 0.017	1.039TyrPro: 1.039 ± 0.016	0.844TyrGln: 0.844 ± 0.015	1.318TyrArg: 1.318 ± 0.018	1.566TyrSer: 1.566 ± 0.024	1.242TyrThr: 1.242 ± 0.021	1.524TyrVal: 1.524 ± 0.023	0.356TyrTrp: 0.356 ± 0.009	0.683TyrTyr: 0.683 ± 0.015	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 9799 proteins (4166057 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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