Amino acid dipepetide frequency for Shewanella mangrovi

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	10.944AlaAla: 10.944 ± 0.151	1.069AlaCys: 1.069 ± 0.033	5.892AlaAsp: 5.892 ± 0.091	6.691AlaGlu: 6.691 ± 0.121	3.459AlaPhe: 3.459 ± 0.062	6.969AlaGly: 6.969 ± 0.086	1.837AlaHis: 1.837 ± 0.041	6.055AlaIle: 6.055 ± 0.072	5.204AlaLys: 5.204 ± 0.075	11.008AlaLeu: 11.008 ± 0.125	2.916AlaMet: 2.916 ± 0.055	4.078AlaAsn: 4.078 ± 0.061	3.512AlaPro: 3.512 ± 0.066	4.578AlaGln: 4.578 ± 0.076	4.182AlaArg: 4.182 ± 0.063	5.894AlaSer: 5.894 ± 0.072	5.156AlaThr: 5.156 ± 0.069	6.811AlaVal: 6.811 ± 0.086	1.129AlaTrp: 1.129 ± 0.033	2.473AlaTyr: 2.473 ± 0.05	0.0AlaXaa: 0.0 ± 0.0
Cys	0.903CysAla: 0.903 ± 0.033	0.206CysCys: 0.206 ± 0.013	0.612CysAsp: 0.612 ± 0.023	0.587CysGlu: 0.587 ± 0.028	0.438CysPhe: 0.438 ± 0.021	0.96CysGly: 0.96 ± 0.032	0.494CysHis: 0.494 ± 0.032	0.547CysIle: 0.547 ± 0.023	0.378CysLys: 0.378 ± 0.019	0.945CysLeu: 0.945 ± 0.03	0.255CysMet: 0.255 ± 0.017	0.354CysAsn: 0.354 ± 0.017	0.472CysPro: 0.472 ± 0.025	0.539CysGln: 0.539 ± 0.025	0.515CysArg: 0.515 ± 0.027	0.756CysSer: 0.756 ± 0.028	0.465CysThr: 0.465 ± 0.026	0.673CysVal: 0.673 ± 0.028	0.147CysTrp: 0.147 ± 0.011	0.327CysTyr: 0.327 ± 0.018	0.0CysXaa: 0.0 ± 0.0
Asp	5.519AspAla: 5.519 ± 0.07	0.576AspCys: 0.576 ± 0.025	3.433AspAsp: 3.433 ± 0.068	3.853AspGlu: 3.853 ± 0.067	2.3AspPhe: 2.3 ± 0.046	4.229AspGly: 4.229 ± 0.072	0.991AspHis: 0.991 ± 0.031	3.792AspIle: 3.792 ± 0.063	3.089AspLys: 3.089 ± 0.058	4.846AspLeu: 4.846 ± 0.071	1.488AspMet: 1.488 ± 0.037	2.525AspAsn: 2.525 ± 0.045	2.046AspPro: 2.046 ± 0.048	1.723AspGln: 1.723 ± 0.044	2.194AspArg: 2.194 ± 0.048	3.436AspSer: 3.436 ± 0.063	2.854AspThr: 2.854 ± 0.053	4.015AspVal: 4.015 ± 0.061	0.924AspTrp: 0.924 ± 0.028	1.991AspTyr: 1.991 ± 0.051	0.0AspXaa: 0.0 ± 0.0
Glu	5.447GluAla: 5.447 ± 0.103	0.475GluCys: 0.475 ± 0.024	2.627GluAsp: 2.627 ± 0.058	3.048GluGlu: 3.048 ± 0.069	2.201GluPhe: 2.201 ± 0.043	3.171GluGly: 3.171 ± 0.065	1.589GluHis: 1.589 ± 0.04	3.302GluIle: 3.302 ± 0.052	2.765GluLys: 2.765 ± 0.055	7.262GluLeu: 7.262 ± 0.103	1.637GluMet: 1.637 ± 0.036	2.069GluAsn: 2.069 ± 0.054	1.906GluPro: 1.906 ± 0.043	4.582GluGln: 4.582 ± 0.075	3.407GluArg: 3.407 ± 0.054	3.02GluSer: 3.02 ± 0.057	2.734GluThr: 2.734 ± 0.054	4.025GluVal: 4.025 ± 0.066	0.685GluTrp: 0.685 ± 0.026	1.643GluTyr: 1.643 ± 0.037	0.0GluXaa: 0.0 ± 0.0
Phe	4.009PheAla: 4.009 ± 0.062	0.501PheCys: 0.501 ± 0.022	2.68PheAsp: 2.68 ± 0.053	2.267PheGlu: 2.267 ± 0.049	1.522PhePhe: 1.522 ± 0.038	3.145PheGly: 3.145 ± 0.057	0.765PheHis: 0.765 ± 0.024	2.365PheIle: 2.365 ± 0.047	1.616PheLys: 1.616 ± 0.038	2.993PheLeu: 2.993 ± 0.05	0.983PheMet: 0.983 ± 0.027	1.848PheAsn: 1.848 ± 0.039	1.394PhePro: 1.394 ± 0.034	1.219PheGln: 1.219 ± 0.033	1.633PheArg: 1.633 ± 0.043	3.08PheSer: 3.08 ± 0.056	2.122PheThr: 2.122 ± 0.046	2.634PheVal: 2.634 ± 0.055	0.509PheTrp: 0.509 ± 0.026	1.35PheTyr: 1.35 ± 0.036	0.0PheXaa: 0.0 ± 0.0
Gly	6.023GlyAla: 6.023 ± 0.082	0.979GlyCys: 0.979 ± 0.034	3.827GlyAsp: 3.827 ± 0.062	4.272GlyGlu: 4.272 ± 0.071	3.271GlyPhe: 3.271 ± 0.053	4.833GlyGly: 4.833 ± 0.091	1.635GlyHis: 1.635 ± 0.04	4.589GlyIle: 4.589 ± 0.066	3.966GlyLys: 3.966 ± 0.058	6.92GlyLeu: 6.92 ± 0.093	2.145GlyMet: 2.145 ± 0.044	2.742GlyAsn: 2.742 ± 0.055	1.774GlyPro: 1.774 ± 0.042	2.923GlyGln: 2.923 ± 0.061	3.299GlyArg: 3.299 ± 0.067	4.172GlySer: 4.172 ± 0.075	3.447GlyThr: 3.447 ± 0.065	5.304GlyVal: 5.304 ± 0.083	0.939GlyTrp: 0.939 ± 0.032	2.62GlyTyr: 2.62 ± 0.05	0.0GlyXaa: 0.0 ± 0.0
His	1.845HisAla: 1.845 ± 0.044	0.363HisCys: 0.363 ± 0.021	1.147HisAsp: 1.147 ± 0.031	1.076HisGlu: 1.076 ± 0.03	1.065HisPhe: 1.065 ± 0.033	1.677HisGly: 1.677 ± 0.041	0.752HisHis: 0.752 ± 0.028	1.316HisIle: 1.316 ± 0.033	0.959HisLys: 0.959 ± 0.027	2.374HisLeu: 2.374 ± 0.045	0.529HisMet: 0.529 ± 0.019	0.91HisAsn: 0.91 ± 0.031	1.194HisPro: 1.194 ± 0.033	1.356HisGln: 1.356 ± 0.037	1.118HisArg: 1.118 ± 0.036	1.398HisSer: 1.398 ± 0.033	1.044HisThr: 1.044 ± 0.031	1.181HisVal: 1.181 ± 0.034	0.445HisTrp: 0.445 ± 0.021	0.908HisTyr: 0.908 ± 0.03	0.0HisXaa: 0.0 ± 0.0
Ile	6.638IleAla: 6.638 ± 0.086	0.676IleCys: 0.676 ± 0.022	3.882IleAsp: 3.882 ± 0.059	3.852IleGlu: 3.852 ± 0.069	1.871IlePhe: 1.871 ± 0.045	4.413IleGly: 4.413 ± 0.085	1.172IleHis: 1.172 ± 0.033	3.071IleIle: 3.071 ± 0.059	2.803IleLys: 2.803 ± 0.052	4.498IleLeu: 4.498 ± 0.074	1.178IleMet: 1.178 ± 0.036	2.744IleAsn: 2.744 ± 0.055	2.329IlePro: 2.329 ± 0.046	1.939IleGln: 1.939 ± 0.045	2.8IleArg: 2.8 ± 0.048	4.16IleSer: 4.16 ± 0.071	3.167IleThr: 3.167 ± 0.058	3.834IleVal: 3.834 ± 0.067	0.568IleTrp: 0.568 ± 0.023	1.576IleTyr: 1.576 ± 0.041	0.0IleXaa: 0.0 ± 0.0
Lys	4.966LysAla: 4.966 ± 0.078	0.311LysCys: 0.311 ± 0.018	2.359LysAsp: 2.359 ± 0.049	2.316LysGlu: 2.316 ± 0.064	1.521LysPhe: 1.521 ± 0.039	3.031LysGly: 3.031 ± 0.052	1.082LysHis: 1.082 ± 0.029	2.339LysIle: 2.339 ± 0.044	2.072LysLys: 2.072 ± 0.054	5.496LysLeu: 5.496 ± 0.075	1.283LysMet: 1.283 ± 0.041	1.631LysAsn: 1.631 ± 0.044	2.241LysPro: 2.241 ± 0.05	2.966LysGln: 2.966 ± 0.057	2.593LysArg: 2.593 ± 0.049	2.639LysSer: 2.639 ± 0.049	2.395LysThr: 2.395 ± 0.042	3.645LysVal: 3.645 ± 0.054	0.47LysTrp: 0.47 ± 0.02	1.253LysTyr: 1.253 ± 0.031	0.0LysXaa: 0.0 ± 0.0
Leu	11.818LeuAla: 11.818 ± 0.12	1.156LeuCys: 1.156 ± 0.035	5.792LeuAsp: 5.792 ± 0.07	5.613LeuGlu: 5.613 ± 0.082	4.039LeuPhe: 4.039 ± 0.062	7.085LeuGly: 7.085 ± 0.098	2.152LeuHis: 2.152 ± 0.049	5.394LeuIle: 5.394 ± 0.079	5.117LeuLys: 5.117 ± 0.07	12.4LeuLeu: 12.4 ± 0.19	2.88LeuMet: 2.88 ± 0.058	4.306LeuAsn: 4.306 ± 0.056	5.107LeuPro: 5.107 ± 0.081	5.081LeuGln: 5.081 ± 0.096	4.988LeuArg: 4.988 ± 0.071	7.705LeuSer: 7.705 ± 0.093	6.131LeuThr: 6.131 ± 0.086	7.312LeuVal: 7.312 ± 0.096	1.197LeuTrp: 1.197 ± 0.044	2.731LeuTyr: 2.731 ± 0.055	0.0LeuXaa: 0.0 ± 0.0
Met	2.835MetAla: 2.835 ± 0.045	0.204MetCys: 0.204 ± 0.014	1.264MetAsp: 1.264 ± 0.035	1.279MetGlu: 1.279 ± 0.033	0.848MetPhe: 0.848 ± 0.031	1.795MetGly: 1.795 ± 0.043	0.511MetHis: 0.511 ± 0.024	1.232MetIle: 1.232 ± 0.034	1.369MetLys: 1.369 ± 0.038	3.2MetLeu: 3.2 ± 0.056	0.84MetMet: 0.84 ± 0.03	0.95MetAsn: 0.95 ± 0.033	1.336MetPro: 1.336 ± 0.037	1.409MetGln: 1.409 ± 0.033	1.308MetArg: 1.308 ± 0.034	1.945MetSer: 1.945 ± 0.036	1.62MetThr: 1.62 ± 0.039	1.844MetVal: 1.844 ± 0.044	0.275MetTrp: 0.275 ± 0.015	0.516MetTyr: 0.516 ± 0.023	0.0MetXaa: 0.0 ± 0.0
Asn	3.883AsnAla: 3.883 ± 0.062	0.416AsnCys: 0.416 ± 0.021	2.098AsnAsp: 2.098 ± 0.045	2.069AsnGlu: 2.069 ± 0.049	1.455AsnPhe: 1.455 ± 0.034	3.204AsnGly: 3.204 ± 0.06	0.877AsnHis: 0.877 ± 0.028	2.501AsnIle: 2.501 ± 0.047	1.742AsnLys: 1.742 ± 0.04	3.685AsnLeu: 3.685 ± 0.062	1.009AsnMet: 1.009 ± 0.032	1.612AsnAsn: 1.612 ± 0.044	2.045AsnPro: 2.045 ± 0.049	1.889AsnGln: 1.889 ± 0.045	1.97AsnArg: 1.97 ± 0.044	2.458AsnSer: 2.458 ± 0.052	2.071AsnThr: 2.071 ± 0.043	2.583AsnVal: 2.583 ± 0.05	0.506AsnTrp: 0.506 ± 0.023	1.259AsnTyr: 1.259 ± 0.034	0.0AsnXaa: 0.0 ± 0.0
Pro	3.865ProAla: 3.865 ± 0.062	0.287ProCys: 0.287 ± 0.015	2.361ProAsp: 2.361 ± 0.048	2.962ProGlu: 2.962 ± 0.062	1.684ProPhe: 1.684 ± 0.038	2.502ProGly: 2.502 ± 0.045	0.852ProHis: 0.852 ± 0.03	2.217ProIle: 2.217 ± 0.051	1.958ProLys: 1.958 ± 0.041	4.647ProLeu: 4.647 ± 0.075	1.135ProMet: 1.135 ± 0.029	1.521ProAsn: 1.521 ± 0.034	1.149ProPro: 1.149 ± 0.036	2.134ProGln: 2.134 ± 0.056	1.493ProArg: 1.493 ± 0.038	2.317ProSer: 2.317 ± 0.04	2.134ProThr: 2.134 ± 0.046	3.134ProVal: 3.134 ± 0.055	0.548ProTrp: 0.548 ± 0.024	1.268ProTyr: 1.268 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	5.04GlnAla: 5.04 ± 0.087	0.426GlnCys: 0.426 ± 0.023	2.07GlnAsp: 2.07 ± 0.048	2.132GlnGlu: 2.132 ± 0.042	1.956GlnPhe: 1.956 ± 0.044	3.164GlnGly: 3.164 ± 0.06	1.574GlnHis: 1.574 ± 0.045	2.592GlnIle: 2.592 ± 0.055	1.81GlnLys: 1.81 ± 0.038	7.079GlnLeu: 7.079 ± 0.118	1.255GlnMet: 1.255 ± 0.035	1.443GlnAsn: 1.443 ± 0.036	2.021GlnPro: 2.021 ± 0.047	5.426GlnGln: 5.426 ± 0.146	3.11GlnArg: 3.11 ± 0.064	2.647GlnSer: 2.647 ± 0.048	2.354GlnThr: 2.354 ± 0.051	3.387GlnVal: 3.387 ± 0.059	0.761GlnTrp: 0.761 ± 0.026	1.566GlnTyr: 1.566 ± 0.04	0.0GlnXaa: 0.0 ± 0.0
Arg	3.952ArgAla: 3.952 ± 0.063	0.523ArgCys: 0.523 ± 0.023	2.701ArgAsp: 2.701 ± 0.061	2.894ArgGlu: 2.894 ± 0.058	2.164ArgPhe: 2.164 ± 0.039	2.858ArgGly: 2.858 ± 0.052	1.328ArgHis: 1.328 ± 0.038	3.156ArgIle: 3.156 ± 0.051	2.217ArgLys: 2.217 ± 0.046	5.333ArgLeu: 5.333 ± 0.075	1.345ArgMet: 1.345 ± 0.035	1.944ArgAsn: 1.944 ± 0.046	1.735ArgPro: 1.735 ± 0.042	2.792ArgGln: 2.792 ± 0.056	2.683ArgArg: 2.683 ± 0.058	2.666ArgSer: 2.666 ± 0.054	2.1ArgThr: 2.1 ± 0.041	3.294ArgVal: 3.294 ± 0.051	0.771ArgTrp: 0.771 ± 0.029	1.971ArgTyr: 1.971 ± 0.042	0.0ArgXaa: 0.0 ± 0.0
Ser	6.135SerAla: 6.135 ± 0.079	0.66SerCys: 0.66 ± 0.024	3.597SerAsp: 3.597 ± 0.067	3.567SerGlu: 3.567 ± 0.055	2.628SerPhe: 2.628 ± 0.043	4.888SerGly: 4.888 ± 0.074	1.476SerHis: 1.476 ± 0.033	3.477SerIle: 3.477 ± 0.062	2.793SerLys: 2.793 ± 0.05	7.062SerLeu: 7.062 ± 0.091	1.64SerMet: 1.64 ± 0.036	2.419SerAsn: 2.419 ± 0.052	2.384SerPro: 2.384 ± 0.051	3.008SerGln: 3.008 ± 0.056	3.133SerArg: 3.133 ± 0.048	4.207SerSer: 4.207 ± 0.073	2.936SerThr: 2.936 ± 0.056	4.369SerVal: 4.369 ± 0.063	0.824SerTrp: 0.824 ± 0.028	2.025SerTyr: 2.025 ± 0.05	0.0SerXaa: 0.0 ± 0.0
Thr	5.236ThrAla: 5.236 ± 0.076	0.464ThrCys: 0.464 ± 0.026	3.025ThrAsp: 3.025 ± 0.06	3.129ThrGlu: 3.129 ± 0.059	1.759ThrPhe: 1.759 ± 0.04	4.027ThrGly: 4.027 ± 0.06	1.128ThrHis: 1.128 ± 0.029	2.859ThrIle: 2.859 ± 0.052	1.97ThrLys: 1.97 ± 0.045	6.162ThrLeu: 6.162 ± 0.08	1.085ThrMet: 1.085 ± 0.032	1.79ThrAsn: 1.79 ± 0.043	2.828ThrPro: 2.828 ± 0.053	2.39ThrGln: 2.39 ± 0.049	2.183ThrArg: 2.183 ± 0.042	3.206ThrSer: 3.206 ± 0.062	2.744ThrThr: 2.744 ± 0.062	3.763ThrVal: 3.763 ± 0.065	0.511ThrTrp: 0.511 ± 0.02	1.309ThrTyr: 1.309 ± 0.038	0.0ThrXaa: 0.0 ± 0.0
Val	7.388ValAla: 7.388 ± 0.093	0.731ValCys: 0.731 ± 0.03	4.153ValAsp: 4.153 ± 0.069	4.144ValGlu: 4.144 ± 0.063	2.536ValPhe: 2.536 ± 0.051	4.711ValGly: 4.711 ± 0.067	1.228ValHis: 1.228 ± 0.038	4.326ValIle: 4.326 ± 0.071	3.328ValLys: 3.328 ± 0.063	6.795ValLeu: 6.795 ± 0.087	1.988ValMet: 1.988 ± 0.045	2.977ValAsn: 2.977 ± 0.051	2.782ValPro: 2.782 ± 0.047	2.434ValGln: 2.434 ± 0.043	3.055ValArg: 3.055 ± 0.06	4.953ValSer: 4.953 ± 0.077	4.245ValThr: 4.245 ± 0.081	5.36ValVal: 5.36 ± 0.08	0.733ValTrp: 0.733 ± 0.025	1.798ValTyr: 1.798 ± 0.042	0.0ValXaa: 0.0 ± 0.0
Trp	0.853TrpAla: 0.853 ± 0.03	0.163TrpCys: 0.163 ± 0.013	0.63TrpAsp: 0.63 ± 0.023	0.443TrpGlu: 0.443 ± 0.02	0.572TrpPhe: 0.572 ± 0.022	0.772TrpGly: 0.772 ± 0.025	0.435TrpHis: 0.435 ± 0.019	0.608TrpIle: 0.608 ± 0.025	0.391TrpLys: 0.391 ± 0.018	1.89TrpLeu: 1.89 ± 0.05	0.364TrpMet: 0.364 ± 0.018	0.398TrpAsn: 0.398 ± 0.02	0.554TrpPro: 0.554 ± 0.024	1.264TrpGln: 1.264 ± 0.038	0.77TrpArg: 0.77 ± 0.029	0.662TrpSer: 0.662 ± 0.023	0.469TrpThr: 0.469 ± 0.021	0.775TrpVal: 0.775 ± 0.029	0.21TrpTrp: 0.21 ± 0.016	0.377TrpTyr: 0.377 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.557TyrAla: 2.557 ± 0.042	0.386TyrCys: 0.386 ± 0.021	1.674TyrAsp: 1.674 ± 0.043	1.402TyrGlu: 1.402 ± 0.041	1.345TyrPhe: 1.345 ± 0.034	2.25TyrGly: 2.25 ± 0.057	0.778TyrHis: 0.778 ± 0.027	1.433TyrIle: 1.433 ± 0.034	1.064TyrLys: 1.064 ± 0.031	3.408TyrLeu: 3.408 ± 0.061	0.625TyrMet: 0.625 ± 0.022	1.069TyrAsn: 1.069 ± 0.036	1.361TyrPro: 1.361 ± 0.034	2.161TyrGln: 2.161 ± 0.048	1.992TyrArg: 1.992 ± 0.04	1.908TyrSer: 1.908 ± 0.04	1.378TyrThr: 1.378 ± 0.035	1.722TyrVal: 1.722 ± 0.041	0.448TyrTrp: 0.448 ± 0.02	1.057TyrTyr: 1.057 ± 0.037	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3384 proteins (1119320 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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