Amino acid dipepetide frequency for Torque teno midi virus 11

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
15.909AlaAla: 15.909 ± 5.561
0.758AlaCys: 0.758 ± 0.414
0.758AlaAsp: 0.758 ± 0.414
5.303AlaGlu: 5.303 ± 0.73
1.515AlaPhe: 1.515 ± 0.669
3.788AlaGly: 3.788 ± 1.34
2.273AlaHis: 2.273 ± 1.451
1.515AlaIle: 1.515 ± 0.829
4.545AlaLys: 4.545 ± 0.845
1.515AlaLeu: 1.515 ± 0.829
0.0AlaMet: 0.0 ± 0.0
3.788AlaAsn: 3.788 ± 0.542
0.758AlaPro: 0.758 ± 0.831
0.0AlaGln: 0.0 ± 0.0
4.545AlaArg: 4.545 ± 1.138
7.576AlaSer: 7.576 ± 2.503
3.03AlaThr: 3.03 ± 2.269
0.758AlaVal: 0.758 ± 0.414
0.758AlaTrp: 0.758 ± 0.414
0.758AlaTyr: 0.758 ± 0.831
0.0AlaXaa: 0.0 ± 0.0
Cys
0.758CysAla: 0.758 ± 0.783
0.758CysCys: 0.758 ± 0.414
1.515CysAsp: 1.515 ± 0.829
0.758CysGlu: 0.758 ± 0.414
0.758CysPhe: 0.758 ± 0.414
0.0CysGly: 0.0 ± 0.0
0.758CysHis: 0.758 ± 0.783
0.758CysIle: 0.758 ± 0.414
0.758CysLys: 0.758 ± 0.414
3.03CysLeu: 3.03 ± 0.879
2.273CysMet: 2.273 ± 1.264
3.03CysAsn: 3.03 ± 0.879
2.273CysPro: 2.273 ± 1.264
0.0CysGln: 0.0 ± 0.0
0.758CysArg: 0.758 ± 0.414
0.0CysSer: 0.0 ± 0.0
0.0CysThr: 0.0 ± 0.0
0.758CysVal: 0.758 ± 0.831
0.758CysTrp: 0.758 ± 0.414
0.758CysTyr: 0.758 ± 0.414
0.0CysXaa: 0.0 ± 0.0
Asp
3.03AspAla: 3.03 ± 0.879
3.03AspCys: 3.03 ± 0.879
0.0AspAsp: 0.0 ± 0.0
0.0AspGlu: 0.0 ± 0.0
5.303AspPhe: 5.303 ± 0.603
4.545AspGly: 4.545 ± 2.527
0.758AspHis: 0.758 ± 0.414
2.273AspIle: 2.273 ± 1.264
1.515AspLys: 1.515 ± 0.829
3.03AspLeu: 3.03 ± 1.657
0.0AspMet: 0.0 ± 0.414
0.758AspAsn: 0.758 ± 0.414
4.545AspPro: 4.545 ± 1.138
0.758AspGln: 0.758 ± 0.414
2.273AspArg: 2.273 ± 1.264
1.515AspSer: 1.515 ± 0.829
7.576AspThr: 7.576 ± 1.084
1.515AspVal: 1.515 ± 0.829
0.758AspTrp: 0.758 ± 0.414
0.758AspTyr: 0.758 ± 0.414
0.0AspXaa: 0.0 ± 0.0
Glu
3.788GluAla: 3.788 ± 0.542
3.03GluCys: 3.03 ± 1.715
6.061GluAsp: 6.061 ± 2.669
9.848GluGlu: 9.848 ± 3.759
0.0GluPhe: 0.0 ± 0.0
2.273GluGly: 2.273 ± 0.809
1.515GluHis: 1.515 ± 0.669
3.03GluIle: 3.03 ± 0.879
2.273GluLys: 2.273 ± 1.264
5.303GluLeu: 5.303 ± 2.16
0.0GluMet: 0.0 ± 0.0
6.818GluAsn: 6.818 ± 1.446
1.515GluPro: 1.515 ± 0.829
2.273GluGln: 2.273 ± 1.451
2.273GluArg: 2.273 ± 0.989
1.515GluSer: 1.515 ± 0.952
4.545GluThr: 4.545 ± 1.706
3.03GluVal: 3.03 ± 1.09
0.0GluTrp: 0.0 ± 0.0
1.515GluTyr: 1.515 ± 0.829
0.0GluXaa: 0.0 ± 0.0
Phe
0.0PheAla: 0.0 ± 0.0
0.0PheCys: 0.0 ± 0.0
0.0PheAsp: 0.0 ± 0.0
0.758PheGlu: 0.758 ± 0.831
3.788PhePhe: 3.788 ± 0.542
6.061PheGly: 6.061 ± 1.759
1.515PheHis: 1.515 ± 0.669
2.273PheIle: 2.273 ± 1.243
5.303PheLys: 5.303 ± 1.918
3.788PheLeu: 3.788 ± 0.542
0.758PheMet: 0.758 ± 0.689
0.0PheAsn: 0.0 ± 0.0
3.03PhePro: 3.03 ± 0.879
3.03PheGln: 3.03 ± 1.657
1.515PheArg: 1.515 ± 0.829
1.515PheSer: 1.515 ± 0.68
3.03PheThr: 3.03 ± 0.879
3.03PheVal: 3.03 ± 1.657
1.515PheTrp: 1.515 ± 0.829
3.03PheTyr: 3.03 ± 0.996
0.0PheXaa: 0.0 ± 0.0
Gly
1.515GlyAla: 1.515 ± 0.829
1.515GlyCys: 1.515 ± 0.829
0.0GlyAsp: 0.0 ± 0.0
3.03GlyGlu: 3.03 ± 0.879
3.03GlyPhe: 3.03 ± 0.996
6.818GlyGly: 6.818 ± 1.401
7.576GlyHis: 7.576 ± 3.399
2.273GlyIle: 2.273 ± 1.243
1.515GlyLys: 1.515 ± 0.829
2.273GlyLeu: 2.273 ± 1.243
0.0GlyMet: 0.0 ± 0.0
2.273GlyAsn: 2.273 ± 1.243
6.061GlyPro: 6.061 ± 1.759
0.0GlyGln: 0.0 ± 0.0
0.758GlyArg: 0.758 ± 0.414
0.758GlySer: 0.758 ± 0.831
3.03GlyThr: 3.03 ± 1.359
4.545GlyVal: 4.545 ± 0.397
0.758GlyTrp: 0.758 ± 0.414
0.0GlyTyr: 0.0 ± 0.0
0.0GlyXaa: 0.0 ± 0.0
His
0.758HisAla: 0.758 ± 0.783
1.515HisCys: 1.515 ± 0.829
2.273HisAsp: 2.273 ± 1.264
0.758HisGlu: 0.758 ± 0.414
2.273HisPhe: 2.273 ± 1.264
0.758HisGly: 0.758 ± 0.414
1.515HisHis: 1.515 ± 1.566
1.515HisIle: 1.515 ± 0.829
3.03HisLys: 3.03 ± 0.345
3.788HisLeu: 3.788 ± 1.479
0.0HisMet: 0.0 ± 0.0
0.0HisAsn: 0.0 ± 0.0
2.273HisPro: 2.273 ± 0.741
6.818HisGln: 6.818 ± 1.514
0.758HisArg: 0.758 ± 0.414
1.515HisSer: 1.515 ± 1.566
3.03HisThr: 3.03 ± 0.996
0.0HisVal: 0.0 ± 0.0
0.758HisTrp: 0.758 ± 0.414
1.515HisTyr: 1.515 ± 0.68
0.0HisXaa: 0.0 ± 0.0
Ile
3.788IleAla: 3.788 ± 1.479
0.0IleCys: 0.0 ± 0.0
0.758IleAsp: 0.758 ± 0.414
3.03IleGlu: 3.03 ± 0.879
3.03IlePhe: 3.03 ± 0.879
0.758IleGly: 0.758 ± 0.414
1.515IleHis: 1.515 ± 0.829
3.03IleIle: 3.03 ± 0.879
6.061IleLys: 6.061 ± 1.759
0.758IleLeu: 0.758 ± 0.414
0.758IleMet: 0.758 ± 0.414
4.545IleAsn: 4.545 ± 0.397
3.788IlePro: 3.788 ± 1.438
3.03IleGln: 3.03 ± 1.09
0.758IleArg: 0.758 ± 0.414
4.545IleSer: 4.545 ± 2.011
3.788IleThr: 3.788 ± 1.334
1.515IleVal: 1.515 ± 0.669
0.0IleTrp: 0.0 ± 0.0
0.0IleTyr: 0.0 ± 0.0
0.0IleXaa: 0.0 ± 0.0
Lys
4.545LysAla: 4.545 ± 1.138
0.758LysCys: 0.758 ± 0.414
1.515LysAsp: 1.515 ± 0.829
9.848LysGlu: 9.848 ± 3.919
2.273LysPhe: 2.273 ± 0.741
3.788LysGly: 3.788 ± 2.071
3.788LysHis: 3.788 ± 0.49
2.273LysIle: 2.273 ± 0.809
9.091LysLys: 9.091 ± 3.234
3.788LysLeu: 3.788 ± 1.435
0.0LysMet: 0.0 ± 0.0
4.545LysAsn: 4.545 ± 0.397
6.061LysPro: 6.061 ± 0.732
6.818LysGln: 6.818 ± 2.765
9.091LysArg: 9.091 ± 0.63
3.03LysSer: 3.03 ± 2.173
7.576LysThr: 7.576 ± 2.944
1.515LysVal: 1.515 ± 0.829
2.273LysTrp: 2.273 ± 1.243
3.03LysTyr: 3.03 ± 1.339
0.0LysXaa: 0.0 ± 0.0
Leu
4.545LeuAla: 4.545 ± 1.138
0.758LeuCys: 0.758 ± 0.414
3.788LeuAsp: 3.788 ± 2.071
2.273LeuGlu: 2.273 ± 1.407
3.03LeuPhe: 3.03 ± 0.879
2.273LeuGly: 2.273 ± 1.243
2.273LeuHis: 2.273 ± 1.243
4.545LeuIle: 4.545 ± 0.996
6.061LeuLys: 6.061 ± 1.157
8.333LeuLeu: 8.333 ± 1.459
0.758LeuMet: 0.758 ± 0.783
1.515LeuAsn: 1.515 ± 0.669
5.303LeuPro: 5.303 ± 0.85
9.091LeuGln: 9.091 ± 3.271
1.515LeuArg: 1.515 ± 0.669
1.515LeuSer: 1.515 ± 0.669
6.061LeuThr: 6.061 ± 0.85
1.515LeuVal: 1.515 ± 0.829
0.758LeuTrp: 0.758 ± 0.414
3.03LeuTyr: 3.03 ± 1.657
0.0LeuXaa: 0.0 ± 0.0
Met
0.0MetAla: 0.0 ± 0.0
3.788MetCys: 3.788 ± 1.34
0.0MetAsp: 0.0 ± 0.0
0.0MetGlu: 0.0 ± 0.0
0.0MetPhe: 0.0 ± 0.0
0.0MetGly: 0.0 ± 0.0
0.758MetHis: 0.758 ± 0.831
2.273MetIle: 2.273 ± 1.264
0.0MetLys: 0.0 ± 0.0
0.758MetLeu: 0.758 ± 0.414
0.0MetMet: 0.0 ± 0.0
0.0MetAsn: 0.0 ± 0.0
0.758MetPro: 0.758 ± 0.414
0.758MetGln: 0.758 ± 0.414
0.758MetArg: 0.758 ± 0.783
5.303MetSer: 5.303 ± 2.137
0.0MetThr: 0.0 ± 0.0
0.0MetVal: 0.0 ± 0.0
2.273MetTrp: 2.273 ± 1.264
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
0.758AsnAla: 0.758 ± 0.414
2.273AsnCys: 2.273 ± 1.264
3.03AsnAsp: 3.03 ± 0.879
0.758AsnGlu: 0.758 ± 0.831
0.758AsnPhe: 0.758 ± 0.831
0.0AsnGly: 0.0 ± 0.0
2.273AsnHis: 2.273 ± 1.264
3.788AsnIle: 3.788 ± 1.479
3.03AsnLys: 3.03 ± 1.657
1.515AsnLeu: 1.515 ± 0.829
0.0AsnMet: 0.0 ± 0.0
3.788AsnAsn: 3.788 ± 0.542
6.061AsnPro: 6.061 ± 1.056
3.788AsnGln: 3.788 ± 0.542
3.03AsnArg: 3.03 ± 1.851
3.788AsnSer: 3.788 ± 0.957
4.545AsnThr: 4.545 ± 2.486
2.273AsnVal: 2.273 ± 1.243
0.0AsnTrp: 0.0 ± 0.0
3.788AsnTyr: 3.788 ± 1.479
0.0AsnXaa: 0.0 ± 0.0
Pro
6.061ProAla: 6.061 ± 4.537
0.758ProCys: 0.758 ± 0.414
5.303ProAsp: 5.303 ± 0.603
4.545ProGlu: 4.545 ± 1.138
6.061ProPhe: 6.061 ± 1.647
3.788ProGly: 3.788 ± 1.479
2.273ProHis: 2.273 ± 0.809
2.273ProIle: 2.273 ± 1.607
5.303ProLys: 5.303 ± 2.203
2.273ProLeu: 2.273 ± 1.243
1.515ProMet: 1.515 ± 0.669
0.0ProAsn: 0.0 ± 0.0
6.818ProPro: 6.818 ± 2.462
0.758ProGln: 0.758 ± 0.414
4.545ProArg: 4.545 ± 3.921
7.576ProSer: 7.576 ± 1.752
6.061ProThr: 6.061 ± 0.956
1.515ProVal: 1.515 ± 0.829
0.758ProTrp: 0.758 ± 0.831
6.061ProTyr: 6.061 ± 0.645
0.0ProXaa: 0.0 ± 0.0
Gln
3.03GlnAla: 3.03 ± 1.09
0.0GlnCys: 0.0 ± 0.0
3.788GlnAsp: 3.788 ± 0.542
3.03GlnGlu: 3.03 ± 0.996
0.0GlnPhe: 0.0 ± 0.0
2.273GlnGly: 2.273 ± 1.243
0.758GlnHis: 0.758 ± 0.414
3.788GlnIle: 3.788 ± 1.438
4.545GlnLys: 4.545 ± 2.039
7.576GlnLeu: 7.576 ± 2.448
3.788GlnMet: 3.788 ± 1.34
0.758GlnAsn: 0.758 ± 0.414
3.03GlnPro: 3.03 ± 1.09
9.091GlnGln: 9.091 ± 2.989
2.273GlnArg: 2.273 ± 1.533
3.788GlnSer: 3.788 ± 1.438
3.03GlnThr: 3.03 ± 0.345
0.758GlnVal: 0.758 ± 0.414
0.758GlnTrp: 0.758 ± 0.414
2.273GlnTyr: 2.273 ± 0.809
0.0GlnXaa: 0.0 ± 0.0
Arg
0.758ArgAla: 0.758 ± 0.414
1.515ArgCys: 1.515 ± 0.669
4.545ArgAsp: 4.545 ± 2.527
3.03ArgGlu: 3.03 ± 1.851
3.03ArgPhe: 3.03 ± 0.879
2.273ArgGly: 2.273 ± 0.741
0.758ArgHis: 0.758 ± 0.414
0.758ArgIle: 0.758 ± 0.414
9.091ArgLys: 9.091 ± 1.689
2.273ArgLeu: 2.273 ± 1.451
1.515ArgMet: 1.515 ± 0.708
2.273ArgAsn: 2.273 ± 1.451
3.788ArgPro: 3.788 ± 1.35
0.758ArgGln: 0.758 ± 0.414
12.121ArgArg: 12.121 ± 5.752
0.758ArgSer: 0.758 ± 0.831
2.273ArgThr: 2.273 ± 0.809
0.758ArgVal: 0.758 ± 0.783
0.758ArgTrp: 0.758 ± 0.414
5.303ArgTyr: 5.303 ± 2.203
0.0ArgXaa: 0.0 ± 0.0
Ser
3.03SerAla: 3.03 ± 1.715
0.0SerCys: 0.0 ± 0.0
3.788SerAsp: 3.788 ± 0.542
2.273SerGlu: 2.273 ± 1.264
3.03SerPhe: 3.03 ± 1.09
0.758SerGly: 0.758 ± 0.414
0.758SerHis: 0.758 ± 0.783
2.273SerIle: 2.273 ± 1.264
6.061SerLys: 6.061 ± 3.468
6.061SerLeu: 6.061 ± 1.157
2.273SerMet: 2.273 ± 1.264
6.061SerAsn: 6.061 ± 2.463
5.303SerPro: 5.303 ± 3.027
1.515SerGln: 1.515 ± 0.68
3.03SerArg: 3.03 ± 0.345
8.333SerSer: 8.333 ± 8.613
7.576SerThr: 7.576 ± 3.14
0.758SerVal: 0.758 ± 0.414
0.0SerTrp: 0.0 ± 0.0
1.515SerTyr: 1.515 ± 0.829
0.0SerXaa: 0.0 ± 0.0
Thr
4.545ThrAla: 4.545 ± 0.839
0.0ThrCys: 0.0 ± 0.0
2.273ThrAsp: 2.273 ± 1.243
3.03ThrGlu: 3.03 ± 0.996
2.273ThrPhe: 2.273 ± 1.243
6.061ThrGly: 6.061 ± 0.956
2.273ThrHis: 2.273 ± 0.809
6.061ThrIle: 6.061 ± 0.956
10.606ThrLys: 10.606 ± 1.89
9.091ThrLeu: 9.091 ± 3.234
0.758ThrMet: 0.758 ± 0.682
3.03ThrAsn: 3.03 ± 1.339
6.818ThrPro: 6.818 ± 4.655
3.788ThrGln: 3.788 ± 1.435
0.758ThrArg: 0.758 ± 0.783
4.545ThrSer: 4.545 ± 2.039
5.303ThrThr: 5.303 ± 1.263
3.788ThrVal: 3.788 ± 1.34
0.758ThrTrp: 0.758 ± 0.414
3.03ThrTyr: 3.03 ± 1.657
0.0ThrXaa: 0.0 ± 0.0
Val
0.0ValAla: 0.0 ± 0.0
0.0ValCys: 0.0 ± 0.0
3.03ValAsp: 3.03 ± 0.879
6.061ValGlu: 6.061 ± 0.956
1.515ValPhe: 1.515 ± 0.829
0.758ValGly: 0.758 ± 0.414
0.758ValHis: 0.758 ± 0.783
0.0ValIle: 0.0 ± 0.0
2.273ValLys: 2.273 ± 1.243
0.0ValLeu: 0.0 ± 0.0
0.0ValMet: 0.0 ± 0.0
2.273ValAsn: 2.273 ± 0.741
1.515ValPro: 1.515 ± 0.829
3.03ValGln: 3.03 ± 1.657
2.273ValArg: 2.273 ± 1.243
2.273ValSer: 2.273 ± 1.407
1.515ValThr: 1.515 ± 0.669
1.515ValVal: 1.515 ± 0.829
1.515ValTrp: 1.515 ± 0.829
0.758ValTyr: 0.758 ± 0.414
0.0ValXaa: 0.0 ± 0.0
Trp
0.758TrpAla: 0.758 ± 0.414
0.0TrpCys: 0.0 ± 0.0
1.515TrpAsp: 1.515 ± 0.829
0.758TrpGlu: 0.758 ± 0.414
1.515TrpPhe: 1.515 ± 0.829
0.758TrpGly: 0.758 ± 0.414
0.0TrpHis: 0.0 ± 0.0
0.0TrpIle: 0.0 ± 0.0
0.0TrpLys: 0.0 ± 0.0
1.515TrpLeu: 1.515 ± 0.669
2.273TrpMet: 2.273 ± 1.264
0.0TrpAsn: 0.0 ± 0.0
0.0TrpPro: 0.0 ± 0.0
1.515TrpGln: 1.515 ± 0.829
1.515TrpArg: 1.515 ± 0.829
0.0TrpSer: 0.0 ± 0.0
0.758TrpThr: 0.758 ± 0.414
0.758TrpVal: 0.758 ± 0.414
1.515TrpTrp: 1.515 ± 0.829
1.515TrpTyr: 1.515 ± 0.829
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.273TyrAla: 2.273 ± 0.741
0.0TyrCys: 0.0 ± 0.0
0.758TyrAsp: 0.758 ± 0.414
1.515TyrGlu: 1.515 ± 0.829
0.758TyrPhe: 0.758 ± 0.414
0.0TyrGly: 0.0 ± 0.0
0.758TyrHis: 0.758 ± 0.414
0.758TyrIle: 0.758 ± 0.414
4.545TyrLys: 4.545 ± 0.82
2.273TyrLeu: 2.273 ± 0.741
0.0TyrMet: 0.0 ± 0.0
3.788TyrAsn: 3.788 ± 0.542
4.545TyrPro: 4.545 ± 0.839
1.515TyrGln: 1.515 ± 0.68
3.788TyrArg: 3.788 ± 2.071
4.545TyrSer: 4.545 ± 0.397
6.061TyrThr: 6.061 ± 2.6
0.758TyrVal: 0.758 ± 0.414
0.0TyrTrp: 0.0 ± 0.0
1.515TyrTyr: 1.515 ± 0.829
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4 proteins (1321 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski