Amino acid dipepetide frequency for Pelobacter acetylenicus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	11.357AlaAla: 11.357 ± 0.145	1.649AlaCys: 1.649 ± 0.045	5.549AlaAsp: 5.549 ± 0.079	6.385AlaGlu: 6.385 ± 0.086	3.705AlaPhe: 3.705 ± 0.07	8.982AlaGly: 8.982 ± 0.107	1.773AlaHis: 1.773 ± 0.051	5.306AlaIle: 5.306 ± 0.085	3.267AlaLys: 3.267 ± 0.068	11.228AlaLeu: 11.228 ± 0.128	2.862AlaMet: 2.862 ± 0.062	2.494AlaAsn: 2.494 ± 0.06	3.728AlaPro: 3.728 ± 0.078	3.161AlaGln: 3.161 ± 0.059	7.4AlaArg: 7.4 ± 0.123	5.028AlaSer: 5.028 ± 0.077	4.566AlaThr: 4.566 ± 0.081	7.417AlaVal: 7.417 ± 0.097	1.111AlaTrp: 1.111 ± 0.039	2.33AlaTyr: 2.33 ± 0.052	0.0AlaXaa: 0.0 ± 0.0
Cys	1.203CysAla: 1.203 ± 0.04	0.32CysCys: 0.32 ± 0.019	0.825CysAsp: 0.825 ± 0.031	0.755CysGlu: 0.755 ± 0.031	0.567CysPhe: 0.567 ± 0.025	1.594CysGly: 1.594 ± 0.047	0.415CysHis: 0.415 ± 0.021	0.673CysIle: 0.673 ± 0.03	0.45CysLys: 0.45 ± 0.023	1.587CysLeu: 1.587 ± 0.043	0.306CysMet: 0.306 ± 0.018	0.367CysAsn: 0.367 ± 0.02	0.911CysPro: 0.911 ± 0.043	0.525CysGln: 0.525 ± 0.025	1.253CysArg: 1.253 ± 0.04	0.807CysSer: 0.807 ± 0.029	0.534CysThr: 0.534 ± 0.025	0.829CysVal: 0.829 ± 0.03	0.158CysTrp: 0.158 ± 0.014	0.396CysTyr: 0.396 ± 0.021	0.0CysXaa: 0.0 ± 0.0
Asp	5.365AspAla: 5.365 ± 0.072	0.803AspCys: 0.803 ± 0.03	2.778AspAsp: 2.778 ± 0.085	3.332AspGlu: 3.332 ± 0.068	2.539AspPhe: 2.539 ± 0.056	4.471AspGly: 4.471 ± 0.079	1.187AspHis: 1.187 ± 0.037	3.623AspIle: 3.623 ± 0.062	2.213AspLys: 2.213 ± 0.051	6.335AspLeu: 6.335 ± 0.099	1.448AspMet: 1.448 ± 0.038	1.651AspAsn: 1.651 ± 0.047	2.869AspPro: 2.869 ± 0.047	1.849AspGln: 1.849 ± 0.045	4.011AspArg: 4.011 ± 0.072	2.583AspSer: 2.583 ± 0.057	2.354AspThr: 2.354 ± 0.054	3.53AspVal: 3.53 ± 0.065	0.751AspTrp: 0.751 ± 0.029	1.783AspTyr: 1.783 ± 0.054	0.0AspXaa: 0.0 ± 0.0
Glu	6.338GluAla: 6.338 ± 0.102	0.57GluCys: 0.57 ± 0.027	3.189GluAsp: 3.189 ± 0.062	4.484GluGlu: 4.484 ± 0.08	2.081GluPhe: 2.081 ± 0.046	4.279GluGly: 4.279 ± 0.077	1.316GluHis: 1.316 ± 0.035	4.118GluIle: 4.118 ± 0.072	3.669GluLys: 3.669 ± 0.069	6.342GluLeu: 6.342 ± 0.092	1.778GluMet: 1.778 ± 0.047	2.29GluAsn: 2.29 ± 0.057	2.214GluPro: 2.214 ± 0.05	2.939GluGln: 2.939 ± 0.068	4.331GluArg: 4.331 ± 0.084	2.834GluSer: 2.834 ± 0.054	3.418GluThr: 3.418 ± 0.059	4.412GluVal: 4.412 ± 0.079	0.507GluTrp: 0.507 ± 0.024	1.471GluTyr: 1.471 ± 0.043	0.0GluXaa: 0.0 ± 0.0
Phe	3.618PheAla: 3.618 ± 0.075	0.671PheCys: 0.671 ± 0.03	2.585PheAsp: 2.585 ± 0.058	2.313PheGlu: 2.313 ± 0.058	1.938PhePhe: 1.938 ± 0.051	3.489PheGly: 3.489 ± 0.072	0.843PheHis: 0.843 ± 0.032	2.0PheIle: 2.0 ± 0.053	1.34PheLys: 1.34 ± 0.042	4.091PheLeu: 4.091 ± 0.094	0.994PheMet: 0.994 ± 0.03	1.342PheAsn: 1.342 ± 0.04	1.778PhePro: 1.778 ± 0.044	1.16PheGln: 1.16 ± 0.035	2.583PheArg: 2.583 ± 0.053	2.743PheSer: 2.743 ± 0.055	1.891PheThr: 1.891 ± 0.045	2.643PheVal: 2.643 ± 0.059	0.512PheTrp: 0.512 ± 0.027	1.182PheTyr: 1.182 ± 0.034	0.0PheXaa: 0.0 ± 0.0
Gly	6.856GlyAla: 6.856 ± 0.106	1.383GlyCys: 1.383 ± 0.037	4.314GlyAsp: 4.314 ± 0.091	4.876GlyGlu: 4.876 ± 0.07	3.537GlyPhe: 3.537 ± 0.069	6.595GlyGly: 6.595 ± 0.121	1.855GlyHis: 1.855 ± 0.05	5.055GlyIle: 5.055 ± 0.067	3.983GlyLys: 3.983 ± 0.074	8.695GlyLeu: 8.695 ± 0.099	2.444GlyMet: 2.444 ± 0.057	2.424GlyAsn: 2.424 ± 0.067	2.678GlyPro: 2.678 ± 0.061	3.074GlyGln: 3.074 ± 0.059	5.757GlyArg: 5.757 ± 0.087	4.43GlySer: 4.43 ± 0.084	4.169GlyThr: 4.169 ± 0.079	5.734GlyVal: 5.734 ± 0.081	0.978GlyTrp: 0.978 ± 0.036	2.603GlyTyr: 2.603 ± 0.056	0.0GlyXaa: 0.0 ± 0.0
His	1.984HisAla: 1.984 ± 0.052	0.402HisCys: 0.402 ± 0.021	1.048HisAsp: 1.048 ± 0.036	1.047HisGlu: 1.047 ± 0.033	0.997HisPhe: 0.997 ± 0.033	1.857HisGly: 1.857 ± 0.046	0.617HisHis: 0.617 ± 0.027	1.189HisIle: 1.189 ± 0.035	0.688HisLys: 0.688 ± 0.029	2.518HisLeu: 2.518 ± 0.049	0.461HisMet: 0.461 ± 0.025	0.647HisAsn: 0.647 ± 0.026	1.504HisPro: 1.504 ± 0.04	0.773HisGln: 0.773 ± 0.03	1.703HisArg: 1.703 ± 0.05	1.019HisSer: 1.019 ± 0.037	0.912HisThr: 0.912 ± 0.032	1.376HisVal: 1.376 ± 0.041	0.277HisTrp: 0.277 ± 0.018	0.649HisTyr: 0.649 ± 0.027	0.0HisXaa: 0.0 ± 0.0
Ile	5.617IleAla: 5.617 ± 0.083	0.788IleCys: 0.788 ± 0.027	3.768IleAsp: 3.768 ± 0.063	3.786IleGlu: 3.786 ± 0.076	2.059IlePhe: 2.059 ± 0.055	4.755IleGly: 4.755 ± 0.082	1.197IleHis: 1.197 ± 0.038	2.87IleIle: 2.87 ± 0.061	2.115IleLys: 2.115 ± 0.059	5.83IleLeu: 5.83 ± 0.092	1.231IleMet: 1.231 ± 0.037	1.813IleAsn: 1.813 ± 0.056	2.772IlePro: 2.772 ± 0.056	1.588IleGln: 1.588 ± 0.043	3.715IleArg: 3.715 ± 0.069	3.089IleSer: 3.089 ± 0.072	2.779IleThr: 2.779 ± 0.058	3.829IleVal: 3.829 ± 0.073	0.496IleTrp: 0.496 ± 0.026	1.336IleTyr: 1.336 ± 0.043	0.0IleXaa: 0.0 ± 0.0
Lys	3.829LysAla: 3.829 ± 0.078	0.391LysCys: 0.391 ± 0.026	2.106LysAsp: 2.106 ± 0.051	2.561LysGlu: 2.561 ± 0.063	1.087LysPhe: 1.087 ± 0.034	3.015LysGly: 3.015 ± 0.066	0.811LysHis: 0.811 ± 0.032	2.656LysIle: 2.656 ± 0.063	2.514LysLys: 2.514 ± 0.061	3.667LysLeu: 3.667 ± 0.068	1.027LysMet: 1.027 ± 0.036	1.622LysAsn: 1.622 ± 0.046	1.855LysPro: 1.855 ± 0.055	1.621LysGln: 1.621 ± 0.044	2.565LysArg: 2.565 ± 0.053	2.184LysSer: 2.184 ± 0.051	2.424LysThr: 2.424 ± 0.05	3.019LysVal: 3.019 ± 0.063	0.365LysTrp: 0.365 ± 0.02	0.984LysTyr: 0.984 ± 0.032	0.0LysXaa: 0.0 ± 0.0
Leu	12.176LeuAla: 12.176 ± 0.146	1.542LeuCys: 1.542 ± 0.044	6.29LeuAsp: 6.29 ± 0.091	7.008LeuGlu: 7.008 ± 0.104	4.378LeuPhe: 4.378 ± 0.087	8.374LeuGly: 8.374 ± 0.097	2.409LeuHis: 2.409 ± 0.051	5.032LeuIle: 5.032 ± 0.081	4.576LeuLys: 4.576 ± 0.074	12.333LeuLeu: 12.333 ± 0.158	2.37LeuMet: 2.37 ± 0.054	3.006LeuAsn: 3.006 ± 0.06	5.709LeuPro: 5.709 ± 0.088	4.563LeuGln: 4.563 ± 0.09	8.112LeuArg: 8.112 ± 0.119	6.394LeuSer: 6.394 ± 0.086	5.136LeuThr: 5.136 ± 0.091	7.625LeuVal: 7.625 ± 0.107	1.148LeuTrp: 1.148 ± 0.041	2.484LeuTyr: 2.484 ± 0.051	0.0LeuXaa: 0.0 ± 0.0
Met	2.936MetAla: 2.936 ± 0.06	0.213MetCys: 0.213 ± 0.016	1.325MetAsp: 1.325 ± 0.038	1.608MetGlu: 1.608 ± 0.042	0.743MetPhe: 0.743 ± 0.028	1.745MetGly: 1.745 ± 0.043	0.507MetHis: 0.507 ± 0.024	1.353MetIle: 1.353 ± 0.044	1.255MetLys: 1.255 ± 0.035	2.599MetLeu: 2.599 ± 0.047	0.56MetMet: 0.56 ± 0.028	0.828MetAsn: 0.828 ± 0.029	1.4MetPro: 1.4 ± 0.045	0.998MetGln: 0.998 ± 0.03	1.579MetArg: 1.579 ± 0.036	1.368MetSer: 1.368 ± 0.041	1.382MetThr: 1.382 ± 0.039	1.962MetVal: 1.962 ± 0.049	0.141MetTrp: 0.141 ± 0.012	0.359MetTyr: 0.359 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	2.62AsnAla: 2.62 ± 0.059	0.41AsnCys: 0.41 ± 0.023	1.505AsnAsp: 1.505 ± 0.054	1.393AsnGlu: 1.393 ± 0.035	1.152AsnPhe: 1.152 ± 0.039	2.25AsnGly: 2.25 ± 0.059	0.675AsnHis: 0.675 ± 0.026	2.036AsnIle: 2.036 ± 0.049	1.09AsnLys: 1.09 ± 0.035	3.839AsnLeu: 3.839 ± 0.056	0.684AsnMet: 0.684 ± 0.029	0.905AsnAsn: 0.905 ± 0.035	2.012AsnPro: 2.012 ± 0.051	1.019AsnGln: 1.019 ± 0.029	2.319AsnArg: 2.319 ± 0.048	1.419AsnSer: 1.419 ± 0.046	1.359AsnThr: 1.359 ± 0.041	1.885AsnVal: 1.885 ± 0.048	0.361AsnTrp: 0.361 ± 0.019	0.812AsnTyr: 0.812 ± 0.032	0.0AsnXaa: 0.0 ± 0.0
Pro	4.996ProAla: 4.996 ± 0.093	0.663ProCys: 0.663 ± 0.027	3.108ProAsp: 3.108 ± 0.057	3.716ProGlu: 3.716 ± 0.077	1.922ProPhe: 1.922 ± 0.057	4.337ProGly: 4.337 ± 0.079	0.987ProHis: 0.987 ± 0.031	1.822ProIle: 1.822 ± 0.044	1.317ProLys: 1.317 ± 0.043	5.052ProLeu: 5.052 ± 0.083	1.13ProMet: 1.13 ± 0.034	1.054ProAsn: 1.054 ± 0.037	2.106ProPro: 2.106 ± 0.057	1.61ProGln: 1.61 ± 0.044	2.793ProArg: 2.793 ± 0.054	2.298ProSer: 2.298 ± 0.052	1.937ProThr: 1.937 ± 0.054	4.075ProVal: 4.075 ± 0.075	0.575ProTrp: 0.575 ± 0.024	1.101ProTyr: 1.101 ± 0.039	0.0ProXaa: 0.0 ± 0.0
Gln	4.25GlnAla: 4.25 ± 0.082	0.402GlnCys: 0.402 ± 0.019	1.794GlnAsp: 1.794 ± 0.048	2.411GlnGlu: 2.411 ± 0.052	1.098GlnPhe: 1.098 ± 0.034	2.913GlnGly: 2.913 ± 0.059	0.769GlnHis: 0.769 ± 0.03	2.0GlnIle: 2.0 ± 0.045	1.844GlnLys: 1.844 ± 0.053	3.893GlnLeu: 3.893 ± 0.079	0.916GlnMet: 0.916 ± 0.037	1.126GlnAsn: 1.126 ± 0.038	1.689GlnPro: 1.689 ± 0.051	1.98GlnGln: 1.98 ± 0.058	2.866GlnArg: 2.866 ± 0.064	1.831GlnSer: 1.831 ± 0.046	1.743GlnThr: 1.743 ± 0.049	2.958GlnVal: 2.958 ± 0.052	0.432GlnTrp: 0.432 ± 0.024	0.75GlnTyr: 0.75 ± 0.031	0.0GlnXaa: 0.0 ± 0.0
Arg	5.763ArgAla: 5.763 ± 0.092	1.034ArgCys: 1.034 ± 0.037	3.961ArgAsp: 3.961 ± 0.073	4.866ArgGlu: 4.866 ± 0.078	3.117ArgPhe: 3.117 ± 0.057	4.637ArgGly: 4.637 ± 0.077	1.945ArgHis: 1.945 ± 0.051	4.608ArgIle: 4.608 ± 0.087	3.112ArgLys: 3.112 ± 0.058	8.34ArgLeu: 8.34 ± 0.132	1.827ArgMet: 1.827 ± 0.045	2.203ArgAsn: 2.203 ± 0.048	2.937ArgPro: 2.937 ± 0.065	3.869ArgGln: 3.869 ± 0.082	5.684ArgArg: 5.684 ± 0.112	3.526ArgSer: 3.526 ± 0.071	2.921ArgThr: 2.921 ± 0.054	4.567ArgVal: 4.567 ± 0.08	0.897ArgTrp: 0.897 ± 0.037	2.173ArgTyr: 2.173 ± 0.043	0.0ArgXaa: 0.0 ± 0.0
Ser	4.865SerAla: 4.865 ± 0.079	0.86SerCys: 0.86 ± 0.032	2.753SerAsp: 2.753 ± 0.06	2.957SerGlu: 2.957 ± 0.056	2.332SerPhe: 2.332 ± 0.052	5.267SerGly: 5.267 ± 0.094	1.14SerHis: 1.14 ± 0.036	2.728SerIle: 2.728 ± 0.054	1.671SerLys: 1.671 ± 0.048	6.191SerLeu: 6.191 ± 0.091	1.358SerMet: 1.358 ± 0.041	1.448SerAsn: 1.448 ± 0.04	2.586SerPro: 2.586 ± 0.056	1.787SerGln: 1.787 ± 0.052	4.076SerArg: 4.076 ± 0.066	2.798SerSer: 2.798 ± 0.072	2.218SerThr: 2.218 ± 0.047	3.561SerVal: 3.561 ± 0.067	0.681SerTrp: 0.681 ± 0.029	1.399SerTyr: 1.399 ± 0.044	0.0SerXaa: 0.0 ± 0.0
Thr	4.898ThrAla: 4.898 ± 0.084	0.725ThrCys: 0.725 ± 0.03	2.508ThrAsp: 2.508 ± 0.058	2.524ThrGlu: 2.524 ± 0.057	1.86ThrPhe: 1.86 ± 0.054	4.642ThrGly: 4.642 ± 0.08	0.947ThrHis: 0.947 ± 0.031	2.679ThrIle: 2.679 ± 0.051	1.255ThrLys: 1.255 ± 0.047	5.737ThrLeu: 5.737 ± 0.087	1.06ThrMet: 1.06 ± 0.034	1.271ThrAsn: 1.271 ± 0.038	2.641ThrPro: 2.641 ± 0.071	1.222ThrGln: 1.222 ± 0.037	3.026ThrArg: 3.026 ± 0.061	2.401ThrSer: 2.401 ± 0.052	2.344ThrThr: 2.344 ± 0.068	3.974ThrVal: 3.974 ± 0.071	0.462ThrTrp: 0.462 ± 0.025	1.167ThrTyr: 1.167 ± 0.038	0.0ThrXaa: 0.0 ± 0.0
Val	7.514ValAla: 7.514 ± 0.089	1.142ValCys: 1.142 ± 0.043	4.042ValAsp: 4.042 ± 0.066	4.587ValGlu: 4.587 ± 0.091	2.977ValPhe: 2.977 ± 0.054	5.234ValGly: 5.234 ± 0.089	1.347ValHis: 1.347 ± 0.039	3.962ValIle: 3.962 ± 0.068	2.653ValLys: 2.653 ± 0.056	7.777ValLeu: 7.777 ± 0.102	1.701ValMet: 1.701 ± 0.04	2.121ValAsn: 2.121 ± 0.052	3.383ValPro: 3.383 ± 0.08	2.172ValGln: 2.172 ± 0.046	4.903ValArg: 4.903 ± 0.065	4.083ValSer: 4.083 ± 0.069	3.706ValThr: 3.706 ± 0.068	5.756ValVal: 5.756 ± 0.095	0.673ValTrp: 0.673 ± 0.029	1.66ValTyr: 1.66 ± 0.04	0.0ValXaa: 0.0 ± 0.0
Trp	0.798TrpAla: 0.798 ± 0.033	0.153TrpCys: 0.153 ± 0.012	0.544TrpAsp: 0.544 ± 0.021	0.604TrpGlu: 0.604 ± 0.027	0.478TrpPhe: 0.478 ± 0.022	0.81TrpGly: 0.81 ± 0.034	0.304TrpHis: 0.304 ± 0.018	0.567TrpIle: 0.567 ± 0.027	0.482TrpLys: 0.482 ± 0.024	1.378TrpLeu: 1.378 ± 0.042	0.227TrpMet: 0.227 ± 0.017	0.352TrpAsn: 0.352 ± 0.021	0.512TrpPro: 0.512 ± 0.025	0.687TrpGln: 0.687 ± 0.03	0.923TrpArg: 0.923 ± 0.036	0.612TrpSer: 0.612 ± 0.026	0.472TrpThr: 0.472 ± 0.024	0.634TrpVal: 0.634 ± 0.025	0.167TrpTrp: 0.167 ± 0.014	0.268TrpTyr: 0.268 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.317TyrAla: 2.317 ± 0.059	0.355TyrCys: 0.355 ± 0.02	1.481TyrAsp: 1.481 ± 0.042	1.368TyrGlu: 1.368 ± 0.041	1.148TyrPhe: 1.148 ± 0.032	2.193TyrGly: 2.193 ± 0.049	0.626TyrHis: 0.626 ± 0.027	1.157TyrIle: 1.157 ± 0.042	0.809TyrLys: 0.809 ± 0.027	3.229TyrLeu: 3.229 ± 0.061	0.476TyrMet: 0.476 ± 0.024	0.784TyrAsn: 0.784 ± 0.028	1.315TyrPro: 1.315 ± 0.039	1.068TyrGln: 1.068 ± 0.032	2.387TyrArg: 2.387 ± 0.058	1.232TyrSer: 1.232 ± 0.039	1.08TyrThr: 1.08 ± 0.031	1.605TyrVal: 1.605 ± 0.047	0.277TyrTrp: 0.277 ± 0.019	0.787TyrTyr: 0.787 ± 0.034	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2796 proteins (902541 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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