Amino acid dipepetide frequency for Spiroplasma sabaudiense Ar-1343

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.786AlaAla: 3.786 ± 0.152
0.574AlaCys: 0.574 ± 0.04
2.595AlaAsp: 2.595 ± 0.104
3.026AlaGlu: 3.026 ± 0.186
2.955AlaPhe: 2.955 ± 0.113
3.076AlaGly: 3.076 ± 0.132
0.726AlaHis: 0.726 ± 0.053
5.847AlaIle: 5.847 ± 0.154
5.037AlaLys: 5.037 ± 0.18
5.233AlaLeu: 5.233 ± 0.157
1.356AlaMet: 1.356 ± 0.071
3.569AlaAsn: 3.569 ± 0.104
1.468AlaPro: 1.468 ± 0.082
1.868AlaGln: 1.868 ± 0.089
1.778AlaArg: 1.778 ± 0.073
3.389AlaSer: 3.389 ± 0.1
3.212AlaThr: 3.212 ± 0.116
3.293AlaVal: 3.293 ± 0.115
0.462AlaTrp: 0.462 ± 0.04
1.651AlaTyr: 1.651 ± 0.076
0.0AlaXaa: 0.0 ± 0.0
Cys
0.292CysAla: 0.292 ± 0.031
0.056CysCys: 0.056 ± 0.014
0.407CysAsp: 0.407 ± 0.038
0.493CysGlu: 0.493 ± 0.047
0.475CysPhe: 0.475 ± 0.042
0.487CysGly: 0.487 ± 0.04
0.109CysHis: 0.109 ± 0.02
0.397CysIle: 0.397 ± 0.037
0.481CysLys: 0.481 ± 0.043
0.611CysLeu: 0.611 ± 0.044
0.09CysMet: 0.09 ± 0.017
0.323CysAsn: 0.323 ± 0.034
0.192CysPro: 0.192 ± 0.023
0.282CysGln: 0.282 ± 0.031
0.168CysArg: 0.168 ± 0.021
0.438CysSer: 0.438 ± 0.036
0.242CysThr: 0.242 ± 0.029
0.326CysVal: 0.326 ± 0.032
0.074CysTrp: 0.074 ± 0.016
0.202CysTyr: 0.202 ± 0.024
0.0CysXaa: 0.0 ± 0.0
Asp
2.464AspAla: 2.464 ± 0.09
0.317AspCys: 0.317 ± 0.033
2.706AspAsp: 2.706 ± 0.121
4.109AspGlu: 4.109 ± 0.14
4.485AspPhe: 4.485 ± 0.129
2.495AspGly: 2.495 ± 0.101
0.673AspHis: 0.673 ± 0.045
4.6AspIle: 4.6 ± 0.112
4.624AspLys: 4.624 ± 0.156
6.182AspLeu: 6.182 ± 0.162
0.95AspMet: 0.95 ± 0.049
3.389AspAsn: 3.389 ± 0.106
1.456AspPro: 1.456 ± 0.075
1.788AspGln: 1.788 ± 0.078
1.543AspArg: 1.543 ± 0.071
3.492AspSer: 3.492 ± 0.107
1.828AspThr: 1.828 ± 0.073
2.961AspVal: 2.961 ± 0.096
0.742AspTrp: 0.742 ± 0.054
2.598AspTyr: 2.598 ± 0.107
0.0AspXaa: 0.0 ± 0.0
Glu
3.876GluAla: 3.876 ± 0.154
0.261GluCys: 0.261 ± 0.026
3.274GluAsp: 3.274 ± 0.1
5.236GluGlu: 5.236 ± 0.203
3.709GluPhe: 3.709 ± 0.114
2.725GluGly: 2.725 ± 0.092
0.739GluHis: 0.739 ± 0.042
8.33GluIle: 8.33 ± 0.189
7.163GluLys: 7.163 ± 0.197
6.428GluLeu: 6.428 ± 0.152
1.614GluMet: 1.614 ± 0.076
6.052GluAsn: 6.052 ± 0.176
1.682GluPro: 1.682 ± 0.1
2.216GluGln: 2.216 ± 0.087
2.058GluArg: 2.058 ± 0.095
3.743GluSer: 3.743 ± 0.115
3.181GluThr: 3.181 ± 0.098
4.379GluVal: 4.379 ± 0.146
0.602GluTrp: 0.602 ± 0.046
2.216GluTyr: 2.216 ± 0.085
0.0GluXaa: 0.0 ± 0.0
Phe
3.308PheAla: 3.308 ± 0.115
0.447PheCys: 0.447 ± 0.043
3.752PheAsp: 3.752 ± 0.162
4.314PheGlu: 4.314 ± 0.129
3.281PhePhe: 3.281 ± 0.126
3.417PheGly: 3.417 ± 0.12
0.605PheHis: 0.605 ± 0.05
5.282PheIle: 5.282 ± 0.166
5.065PheLys: 5.065 ± 0.137
5.695PheLeu: 5.695 ± 0.187
1.148PheMet: 1.148 ± 0.06
3.96PheAsn: 3.96 ± 0.125
1.214PhePro: 1.214 ± 0.066
2.042PheGln: 2.042 ± 0.082
1.425PheArg: 1.425 ± 0.073
4.326PheSer: 4.326 ± 0.126
2.964PheThr: 2.964 ± 0.107
3.169PheVal: 3.169 ± 0.1
0.692PheTrp: 0.692 ± 0.053
2.228PheTyr: 2.228 ± 0.101
0.0PheXaa: 0.0 ± 0.0
Gly
3.132GlyAla: 3.132 ± 0.125
0.341GlyCys: 0.341 ± 0.037
2.753GlyAsp: 2.753 ± 0.093
3.101GlyGlu: 3.101 ± 0.097
3.2GlyPhe: 3.2 ± 0.12
3.101GlyGly: 3.101 ± 0.155
0.829GlyHis: 0.829 ± 0.054
5.301GlyIle: 5.301 ± 0.155
4.146GlyLys: 4.146 ± 0.13
4.752GlyLeu: 4.752 ± 0.15
1.359GlyMet: 1.359 ± 0.063
2.703GlyAsn: 2.703 ± 0.096
1.319GlyPro: 1.319 ± 0.073
1.729GlyGln: 1.729 ± 0.066
1.834GlyArg: 1.834 ± 0.078
3.389GlySer: 3.389 ± 0.116
2.933GlyThr: 2.933 ± 0.097
3.566GlyVal: 3.566 ± 0.115
0.748GlyTrp: 0.748 ± 0.053
2.051GlyTyr: 2.051 ± 0.085
0.0GlyXaa: 0.0 ± 0.0
His
0.652HisAla: 0.652 ± 0.041
0.106HisCys: 0.106 ± 0.018
0.63HisAsp: 0.63 ± 0.042
0.875HisGlu: 0.875 ± 0.058
0.779HisPhe: 0.779 ± 0.042
0.798HisGly: 0.798 ± 0.048
0.276HisHis: 0.276 ± 0.03
0.944HisIle: 0.944 ± 0.045
1.021HisLys: 1.021 ± 0.05
1.366HisLeu: 1.366 ± 0.064
0.189HisMet: 0.189 ± 0.023
0.869HisAsn: 0.869 ± 0.055
0.481HisPro: 0.481 ± 0.043
0.571HisGln: 0.571 ± 0.04
0.459HisArg: 0.459 ± 0.038
0.819HisSer: 0.819 ± 0.047
0.469HisThr: 0.469 ± 0.034
0.565HisVal: 0.565 ± 0.045
0.186HisTrp: 0.186 ± 0.023
0.484HisTyr: 0.484 ± 0.043
0.0HisXaa: 0.0 ± 0.0
Ile
5.77IleAla: 5.77 ± 0.168
0.822IleCys: 0.822 ± 0.049
5.562IleAsp: 5.562 ± 0.153
6.713IleGlu: 6.713 ± 0.159
5.627IlePhe: 5.627 ± 0.173
5.152IleGly: 5.152 ± 0.144
0.95IleHis: 0.95 ± 0.061
9.447IleIle: 9.447 ± 0.229
8.892IleLys: 8.892 ± 0.188
8.991IleLeu: 8.991 ± 0.204
1.75IleMet: 1.75 ± 0.065
7.455IleAsn: 7.455 ± 0.188
2.824IlePro: 2.824 ± 0.094
2.682IleGln: 2.682 ± 0.106
2.644IleArg: 2.644 ± 0.104
7.694IleSer: 7.694 ± 0.176
5.062IleThr: 5.062 ± 0.116
5.562IleVal: 5.562 ± 0.141
0.819IleTrp: 0.819 ± 0.051
3.327IleTyr: 3.327 ± 0.102
0.0IleXaa: 0.0 ± 0.0
Lys
4.714LysAla: 4.714 ± 0.233
0.329LysCys: 0.329 ± 0.036
4.919LysAsp: 4.919 ± 0.137
6.695LysGlu: 6.695 ± 0.165
4.311LysPhe: 4.311 ± 0.11
3.52LysGly: 3.52 ± 0.131
0.987LysHis: 0.987 ± 0.061
10.577LysIle: 10.577 ± 0.197
9.634LysLys: 9.634 ± 0.212
7.865LysLeu: 7.865 ± 0.18
2.545LysMet: 2.545 ± 0.087
8.507LysAsn: 8.507 ± 0.194
2.539LysPro: 2.539 ± 0.103
2.753LysGln: 2.753 ± 0.095
2.598LysArg: 2.598 ± 0.096
5.645LysSer: 5.645 ± 0.144
5.574LysThr: 5.574 ± 0.116
5.112LysVal: 5.112 ± 0.148
0.906LysTrp: 0.906 ± 0.045
3.358LysTyr: 3.358 ± 0.099
0.0LysXaa: 0.0 ± 0.0
Leu
5.618LeuAla: 5.618 ± 0.144
0.456LeuCys: 0.456 ± 0.042
5.022LeuAsp: 5.022 ± 0.121
6.971LeuGlu: 6.971 ± 0.168
5.152LeuPhe: 5.152 ± 0.157
5.199LeuGly: 5.199 ± 0.157
0.999LeuHis: 0.999 ± 0.061
8.951LeuIle: 8.951 ± 0.219
9.587LeuLys: 9.587 ± 0.213
8.104LeuLeu: 8.104 ± 0.169
2.151LeuMet: 2.151 ± 0.09
6.57LeuAsn: 6.57 ± 0.163
2.694LeuPro: 2.694 ± 0.08
3.135LeuGln: 3.135 ± 0.098
2.725LeuArg: 2.725 ± 0.094
6.217LeuSer: 6.217 ± 0.146
5.208LeuThr: 5.208 ± 0.123
5.785LeuVal: 5.785 ± 0.143
0.85LeuTrp: 0.85 ± 0.052
2.511LeuTyr: 2.511 ± 0.092
0.0LeuXaa: 0.0 ± 0.0
Met
1.452MetAla: 1.452 ± 0.068
0.087MetCys: 0.087 ± 0.015
0.944MetAsp: 0.944 ± 0.055
1.142MetGlu: 1.142 ± 0.059
0.912MetPhe: 0.912 ± 0.056
1.217MetGly: 1.217 ± 0.077
0.233MetHis: 0.233 ± 0.027
1.93MetIle: 1.93 ± 0.093
2.371MetLys: 2.371 ± 0.079
1.8MetLeu: 1.8 ± 0.077
0.4MetMet: 0.4 ± 0.034
1.344MetAsn: 1.344 ± 0.061
0.708MetPro: 0.708 ± 0.047
0.754MetGln: 0.754 ± 0.051
0.711MetArg: 0.711 ± 0.05
1.403MetSer: 1.403 ± 0.074
1.279MetThr: 1.279 ± 0.06
1.471MetVal: 1.471 ± 0.066
0.161MetTrp: 0.161 ± 0.023
0.565MetTyr: 0.565 ± 0.038
0.0MetXaa: 0.0 ± 0.0
Asn
3.017AsnAla: 3.017 ± 0.096
0.484AsnCys: 0.484 ± 0.038
3.963AsnAsp: 3.963 ± 0.11
4.894AsnGlu: 4.894 ± 0.136
5.192AsnPhe: 5.192 ± 0.154
3.256AsnGly: 3.256 ± 0.115
1.198AsnHis: 1.198 ± 0.066
6.024AsnIle: 6.024 ± 0.167
6.483AsnLys: 6.483 ± 0.178
7.849AsnLeu: 7.849 ± 0.204
1.151AsnMet: 1.151 ± 0.056
5.776AsnAsn: 5.776 ± 0.195
2.706AsnPro: 2.706 ± 0.101
3.563AsnGln: 3.563 ± 0.114
2.135AsnArg: 2.135 ± 0.082
5.267AsnSer: 5.267 ± 0.138
2.536AsnThr: 2.536 ± 0.097
3.225AsnVal: 3.225 ± 0.092
0.947AsnTrp: 0.947 ± 0.065
3.249AsnTyr: 3.249 ± 0.11
0.0AsnXaa: 0.0 ± 0.0
Pro
1.297ProAla: 1.297 ± 0.081
0.124ProCys: 0.124 ± 0.018
1.362ProAsp: 1.362 ± 0.065
2.551ProGlu: 2.551 ± 0.098
1.546ProPhe: 1.546 ± 0.077
1.651ProGly: 1.651 ± 0.078
0.4ProHis: 0.4 ± 0.04
2.815ProIle: 2.815 ± 0.108
2.418ProLys: 2.418 ± 0.084
2.56ProLeu: 2.56 ± 0.082
0.543ProMet: 0.543 ± 0.046
1.949ProAsn: 1.949 ± 0.086
0.599ProPro: 0.599 ± 0.049
1.012ProGln: 1.012 ± 0.064
0.732ProArg: 0.732 ± 0.05
1.729ProSer: 1.729 ± 0.078
1.555ProThr: 1.555 ± 0.074
1.819ProVal: 1.819 ± 0.099
0.304ProTrp: 0.304 ± 0.03
0.888ProTyr: 0.888 ± 0.062
0.0ProXaa: 0.0 ± 0.0
Gln
1.952GlnAla: 1.952 ± 0.072
0.106GlnCys: 0.106 ± 0.018
1.648GlnAsp: 1.648 ± 0.073
2.809GlnGlu: 2.809 ± 0.107
1.76GlnPhe: 1.76 ± 0.083
1.71GlnGly: 1.71 ± 0.071
0.407GlnHis: 0.407 ± 0.038
3.852GlnIle: 3.852 ± 0.105
3.758GlnLys: 3.758 ± 0.124
2.914GlnLeu: 2.914 ± 0.109
0.717GlnMet: 0.717 ± 0.048
2.939GlnAsn: 2.939 ± 0.096
0.881GlnPro: 0.881 ± 0.058
1.117GlnGln: 1.117 ± 0.059
1.114GlnArg: 1.114 ± 0.064
1.875GlnSer: 1.875 ± 0.071
1.98GlnThr: 1.98 ± 0.076
2.101GlnVal: 2.101 ± 0.088
0.289GlnTrp: 0.289 ± 0.035
0.934GlnTyr: 0.934 ± 0.054
0.0GlnXaa: 0.0 ± 0.0
Arg
1.552ArgAla: 1.552 ± 0.078
0.168ArgCys: 0.168 ± 0.024
1.66ArgAsp: 1.66 ± 0.078
2.207ArgGlu: 2.207 ± 0.085
1.695ArgPhe: 1.695 ± 0.067
1.601ArgGly: 1.601 ± 0.082
0.456ArgHis: 0.456 ± 0.035
2.821ArgIle: 2.821 ± 0.106
2.598ArgLys: 2.598 ± 0.095
2.644ArgLeu: 2.644 ± 0.102
0.701ArgMet: 0.701 ± 0.048
2.042ArgAsn: 2.042 ± 0.075
0.847ArgPro: 0.847 ± 0.049
1.22ArgGln: 1.22 ± 0.06
1.254ArgArg: 1.254 ± 0.079
1.825ArgSer: 1.825 ± 0.079
1.425ArgThr: 1.425 ± 0.066
1.825ArgVal: 1.825 ± 0.073
0.307ArgTrp: 0.307 ± 0.033
1.17ArgTyr: 1.17 ± 0.058
0.0ArgXaa: 0.0 ± 0.0
Ser
3.246SerAla: 3.246 ± 0.106
0.453SerCys: 0.453 ± 0.037
3.693SerAsp: 3.693 ± 0.108
4.494SerGlu: 4.494 ± 0.127
3.858SerPhe: 3.858 ± 0.119
4.125SerGly: 4.125 ± 0.13
0.912SerHis: 0.912 ± 0.049
5.829SerIle: 5.829 ± 0.143
6.487SerLys: 6.487 ± 0.156
6.403SerLeu: 6.403 ± 0.152
1.241SerMet: 1.241 ± 0.073
4.677SerAsn: 4.677 ± 0.134
1.704SerPro: 1.704 ± 0.08
2.889SerGln: 2.889 ± 0.104
2.079SerArg: 2.079 ± 0.09
4.808SerSer: 4.808 ± 0.141
3.302SerThr: 3.302 ± 0.112
3.504SerVal: 3.504 ± 0.106
0.751SerTrp: 0.751 ± 0.057
2.533SerTyr: 2.533 ± 0.089
0.0SerXaa: 0.0 ± 0.0
Thr
2.827ThrAla: 2.827 ± 0.12
0.264ThrCys: 0.264 ± 0.034
2.505ThrAsp: 2.505 ± 0.087
2.837ThrGlu: 2.837 ± 0.102
2.74ThrPhe: 2.74 ± 0.101
3.085ThrGly: 3.085 ± 0.103
0.677ThrHis: 0.677 ± 0.043
5.254ThrIle: 5.254 ± 0.133
4.531ThrLys: 4.531 ± 0.124
4.634ThrLeu: 4.634 ± 0.121
1.03ThrMet: 1.03 ± 0.062
3.603ThrAsn: 3.603 ± 0.116
1.822ThrPro: 1.822 ± 0.092
1.561ThrGln: 1.561 ± 0.073
1.465ThrArg: 1.465 ± 0.061
3.765ThrSer: 3.765 ± 0.111
3.209ThrThr: 3.209 ± 0.118
2.865ThrVal: 2.865 ± 0.097
0.518ThrTrp: 0.518 ± 0.041
1.648ThrTyr: 1.648 ± 0.072
0.0ThrXaa: 0.0 ± 0.0
Val
3.892ValAla: 3.892 ± 0.125
0.394ValCys: 0.394 ± 0.031
3.302ValAsp: 3.302 ± 0.099
3.901ValGlu: 3.901 ± 0.106
3.253ValPhe: 3.253 ± 0.124
3.433ValGly: 3.433 ± 0.115
0.658ValHis: 0.658 ± 0.039
5.863ValIle: 5.863 ± 0.145
4.742ValLys: 4.742 ± 0.112
5.189ValLeu: 5.189 ± 0.151
1.151ValMet: 1.151 ± 0.059
3.762ValAsn: 3.762 ± 0.103
1.539ValPro: 1.539 ± 0.071
1.57ValGln: 1.57 ± 0.078
1.769ValArg: 1.769 ± 0.076
3.979ValSer: 3.979 ± 0.12
2.948ValThr: 2.948 ± 0.096
4.109ValVal: 4.109 ± 0.121
0.552ValTrp: 0.552 ± 0.046
1.918ValTyr: 1.918 ± 0.08
0.0ValXaa: 0.0 ± 0.0
Trp
0.556TrpAla: 0.556 ± 0.043
0.04TrpCys: 0.04 ± 0.011
0.646TrpAsp: 0.646 ± 0.047
0.695TrpGlu: 0.695 ± 0.051
0.673TrpPhe: 0.673 ± 0.048
0.493TrpGly: 0.493 ± 0.047
0.152TrpHis: 0.152 ± 0.022
1.108TrpIle: 1.108 ± 0.068
0.956TrpLys: 0.956 ± 0.053
0.875TrpLeu: 0.875 ± 0.056
0.279TrpMet: 0.279 ± 0.03
0.829TrpAsn: 0.829 ± 0.051
0.217TrpPro: 0.217 ± 0.028
0.27TrpGln: 0.27 ± 0.026
0.273TrpArg: 0.273 ± 0.036
0.72TrpSer: 0.72 ± 0.052
0.599TrpThr: 0.599 ± 0.045
0.605TrpVal: 0.605 ± 0.046
0.146TrpTrp: 0.146 ± 0.023
0.388TrpTyr: 0.388 ± 0.04
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.499TyrAla: 1.499 ± 0.074
0.317TyrCys: 0.317 ± 0.035
2.058TyrAsp: 2.058 ± 0.09
2.421TyrGlu: 2.421 ± 0.104
2.734TyrPhe: 2.734 ± 0.103
1.747TyrGly: 1.747 ± 0.081
0.552TyrHis: 0.552 ± 0.04
2.573TyrIle: 2.573 ± 0.086
3.091TyrLys: 3.091 ± 0.1
3.808TyrLeu: 3.808 ± 0.134
0.512TyrMet: 0.512 ± 0.039
2.598TyrAsn: 2.598 ± 0.089
0.962TyrPro: 0.962 ± 0.056
1.84TyrGln: 1.84 ± 0.079
1.254TyrArg: 1.254 ± 0.06
2.467TyrSer: 2.467 ± 0.094
1.335TyrThr: 1.335 ± 0.07
1.685TyrVal: 1.685 ± 0.071
0.462TyrTrp: 0.462 ± 0.041
1.44TyrTyr: 1.44 ± 0.071
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 924 proteins (322205 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski