Amino acid dipepetide frequency for Nibricoccus aquaticus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	15.041AlaAla: 15.041 ± 0.165	1.031AlaCys: 1.031 ± 0.031	5.996AlaAsp: 5.996 ± 0.065	6.928AlaGlu: 6.928 ± 0.1	4.416AlaPhe: 4.416 ± 0.054	9.322AlaGly: 9.322 ± 0.109	2.319AlaHis: 2.319 ± 0.046	5.23AlaIle: 5.23 ± 0.07	4.955AlaLys: 4.955 ± 0.085	12.568AlaLeu: 12.568 ± 0.136	2.33AlaMet: 2.33 ± 0.043	3.19AlaAsn: 3.19 ± 0.059	5.532AlaPro: 5.532 ± 0.086	4.058AlaGln: 4.058 ± 0.064	7.887AlaArg: 7.887 ± 0.091	7.15AlaSer: 7.15 ± 0.106	7.111AlaThr: 7.111 ± 0.115	7.819AlaVal: 7.819 ± 0.099	1.699AlaTrp: 1.699 ± 0.042	2.434AlaTyr: 2.434 ± 0.045	0.0AlaXaa: 0.0 ± 0.0
Cys	1.033CysAla: 1.033 ± 0.031	0.111CysCys: 0.111 ± 0.009	0.46CysAsp: 0.46 ± 0.018	0.468CysGlu: 0.468 ± 0.02	0.35CysPhe: 0.35 ± 0.015	0.79CysGly: 0.79 ± 0.025	0.221CysHis: 0.221 ± 0.013	0.396CysIle: 0.396 ± 0.016	0.207CysLys: 0.207 ± 0.014	0.817CysLeu: 0.817 ± 0.023	0.124CysMet: 0.124 ± 0.008	0.197CysAsn: 0.197 ± 0.013	0.436CysPro: 0.436 ± 0.017	0.214CysGln: 0.214 ± 0.014	0.594CysArg: 0.594 ± 0.02	0.509CysSer: 0.509 ± 0.021	0.428CysThr: 0.428 ± 0.017	0.701CysVal: 0.701 ± 0.028	0.126CysTrp: 0.126 ± 0.01	0.199CysTyr: 0.199 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	6.073AspAla: 6.073 ± 0.062	0.411AspCys: 0.411 ± 0.019	2.624AspAsp: 2.624 ± 0.049	3.174AspGlu: 3.174 ± 0.059	2.478AspPhe: 2.478 ± 0.043	4.446AspGly: 4.446 ± 0.068	1.077AspHis: 1.077 ± 0.03	2.222AspIle: 2.222 ± 0.039	1.697AspLys: 1.697 ± 0.038	5.247AspLeu: 5.247 ± 0.067	0.712AspMet: 0.712 ± 0.025	1.388AspAsn: 1.388 ± 0.034	2.833AspPro: 2.833 ± 0.044	1.585AspGln: 1.585 ± 0.034	3.27AspArg: 3.27 ± 0.045	2.689AspSer: 2.689 ± 0.056	2.688AspThr: 2.688 ± 0.056	3.49AspVal: 3.49 ± 0.049	0.899AspTrp: 0.899 ± 0.027	1.587AspTyr: 1.587 ± 0.027	0.0AspXaa: 0.0 ± 0.0
Glu	6.296GluAla: 6.296 ± 0.096	0.397GluCys: 0.397 ± 0.017	2.234GluAsp: 2.234 ± 0.044	2.944GluGlu: 2.944 ± 0.051	2.176GluPhe: 2.176 ± 0.044	3.557GluGly: 3.557 ± 0.058	1.119GluHis: 1.119 ± 0.03	3.517GluIle: 3.517 ± 0.056	3.537GluLys: 3.537 ± 0.07	6.139GluLeu: 6.139 ± 0.085	1.194GluMet: 1.194 ± 0.033	2.073GluAsn: 2.073 ± 0.04	2.376GluPro: 2.376 ± 0.038	2.048GluGln: 2.048 ± 0.044	4.271GluArg: 4.271 ± 0.075	3.065GluSer: 3.065 ± 0.051	3.518GluThr: 3.518 ± 0.052	3.72GluVal: 3.72 ± 0.062	0.782GluTrp: 0.782 ± 0.025	1.204GluTyr: 1.204 ± 0.036	0.0GluXaa: 0.0 ± 0.0
Phe	4.647PheAla: 4.647 ± 0.05	0.416PheCys: 0.416 ± 0.015	2.442PheAsp: 2.442 ± 0.042	2.226PheGlu: 2.226 ± 0.042	1.941PhePhe: 1.941 ± 0.04	3.339PheGly: 3.339 ± 0.054	0.826PheHis: 0.826 ± 0.023	1.863PheIle: 1.863 ± 0.039	1.395PheLys: 1.395 ± 0.032	3.908PheLeu: 3.908 ± 0.054	0.715PheMet: 0.715 ± 0.023	1.465PheAsn: 1.465 ± 0.03	1.936PhePro: 1.936 ± 0.037	1.23PheGln: 1.23 ± 0.028	2.421PheArg: 2.421 ± 0.044	2.998PheSer: 2.998 ± 0.055	2.878PheThr: 2.878 ± 0.047	2.785PheVal: 2.785 ± 0.046	0.623PheTrp: 0.623 ± 0.022	1.114PheTyr: 1.114 ± 0.027	0.0PheXaa: 0.0 ± 0.0
Gly	7.803GlyAla: 7.803 ± 0.1	0.748GlyCys: 0.748 ± 0.028	3.734GlyAsp: 3.734 ± 0.057	4.357GlyGlu: 4.357 ± 0.062	3.453GlyPhe: 3.453 ± 0.053	6.775GlyGly: 6.775 ± 0.104	1.71GlyHis: 1.71 ± 0.037	3.951GlyIle: 3.951 ± 0.057	3.774GlyLys: 3.774 ± 0.06	7.926GlyLeu: 7.926 ± 0.087	1.628GlyMet: 1.628 ± 0.033	2.364GlyAsn: 2.364 ± 0.053	2.83GlyPro: 2.83 ± 0.049	2.558GlyGln: 2.558 ± 0.051	5.079GlyArg: 5.079 ± 0.064	4.658GlySer: 4.658 ± 0.077	4.736GlyThr: 4.736 ± 0.097	5.855GlyVal: 5.855 ± 0.076	1.483GlyTrp: 1.483 ± 0.035	2.266GlyTyr: 2.266 ± 0.048	0.0GlyXaa: 0.0 ± 0.0
His	2.573HisAla: 2.573 ± 0.049	0.233HisCys: 0.233 ± 0.014	1.143HisAsp: 1.143 ± 0.03	1.219HisGlu: 1.219 ± 0.033	1.038HisPhe: 1.038 ± 0.025	1.778HisGly: 1.778 ± 0.038	0.65HisHis: 0.65 ± 0.024	0.888HisIle: 0.888 ± 0.025	0.532HisLys: 0.532 ± 0.021	2.281HisLeu: 2.281 ± 0.043	0.298HisMet: 0.298 ± 0.013	0.597HisAsn: 0.597 ± 0.021	1.446HisPro: 1.446 ± 0.036	0.623HisGln: 0.623 ± 0.022	1.501HisArg: 1.501 ± 0.033	1.077HisSer: 1.077 ± 0.032	1.2HisThr: 1.2 ± 0.034	1.347HisVal: 1.347 ± 0.029	0.417HisTrp: 0.417 ± 0.021	0.584HisTyr: 0.584 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	6.143IleAla: 6.143 ± 0.072	0.44IleCys: 0.44 ± 0.017	3.12IleAsp: 3.12 ± 0.054	3.141IleGlu: 3.141 ± 0.049	1.929IlePhe: 1.929 ± 0.038	4.023IleGly: 4.023 ± 0.061	1.075IleHis: 1.075 ± 0.03	2.185IleIle: 2.185 ± 0.045	1.731IleLys: 1.731 ± 0.037	4.353IleLeu: 4.353 ± 0.066	0.649IleMet: 0.649 ± 0.023	1.615IleAsn: 1.615 ± 0.032	2.492IlePro: 2.492 ± 0.049	1.403IleGln: 1.403 ± 0.031	2.973IleArg: 2.973 ± 0.047	2.999IleSer: 2.999 ± 0.05	3.368IleThr: 3.368 ± 0.07	3.732IleVal: 3.732 ± 0.053	0.547IleTrp: 0.547 ± 0.021	1.202IleTyr: 1.202 ± 0.031	0.0IleXaa: 0.0 ± 0.0
Lys	4.354LysAla: 4.354 ± 0.079	0.197LysCys: 0.197 ± 0.012	1.973LysAsp: 1.973 ± 0.047	2.122LysGlu: 2.122 ± 0.044	1.48LysPhe: 1.48 ± 0.032	2.491LysGly: 2.491 ± 0.048	0.823LysHis: 0.823 ± 0.025	2.611LysIle: 2.611 ± 0.047	2.475LysLys: 2.475 ± 0.053	4.274LysLeu: 4.274 ± 0.072	0.976LysMet: 0.976 ± 0.023	1.713LysAsn: 1.713 ± 0.04	2.527LysPro: 2.527 ± 0.049	1.329LysGln: 1.329 ± 0.032	2.653LysArg: 2.653 ± 0.051	2.512LysSer: 2.512 ± 0.045	2.886LysThr: 2.886 ± 0.043	2.48LysVal: 2.48 ± 0.051	0.518LysTrp: 0.518 ± 0.021	0.852LysTyr: 0.852 ± 0.025	0.0LysXaa: 0.0 ± 0.0
Leu	12.984LeuAla: 12.984 ± 0.129	0.997LeuCys: 0.997 ± 0.025	5.179LeuAsp: 5.179 ± 0.078	5.321LeuGlu: 5.321 ± 0.081	3.881LeuPhe: 3.881 ± 0.058	7.99LeuGly: 7.99 ± 0.083	2.247LeuHis: 2.247 ± 0.043	4.844LeuIle: 4.844 ± 0.064	4.412LeuLys: 4.412 ± 0.074	10.244LeuLeu: 10.244 ± 0.129	1.875LeuMet: 1.875 ± 0.044	3.171LeuAsn: 3.171 ± 0.052	5.886LeuPro: 5.886 ± 0.076	2.947LeuGln: 2.947 ± 0.049	7.585LeuArg: 7.585 ± 0.083	6.433LeuSer: 6.433 ± 0.085	6.831LeuThr: 6.831 ± 0.083	6.901LeuVal: 6.901 ± 0.077	1.402LeuTrp: 1.402 ± 0.037	2.032LeuTyr: 2.032 ± 0.036	0.0LeuXaa: 0.0 ± 0.0
Met	1.863MetAla: 1.863 ± 0.042	0.143MetCys: 0.143 ± 0.011	0.871MetAsp: 0.871 ± 0.029	0.952MetGlu: 0.952 ± 0.027	0.563MetPhe: 0.563 ± 0.022	1.232MetGly: 1.232 ± 0.032	0.37MetHis: 0.37 ± 0.017	1.034MetIle: 1.034 ± 0.03	1.121MetLys: 1.121 ± 0.033	1.778MetLeu: 1.778 ± 0.039	0.397MetMet: 0.397 ± 0.017	0.793MetAsn: 0.793 ± 0.023	1.265MetPro: 1.265 ± 0.033	0.584MetGln: 0.584 ± 0.022	1.297MetArg: 1.297 ± 0.035	1.435MetSer: 1.435 ± 0.032	1.24MetThr: 1.24 ± 0.033	1.085MetVal: 1.085 ± 0.03	0.206MetTrp: 0.206 ± 0.014	0.285MetTyr: 0.285 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	3.468AsnAla: 3.468 ± 0.061	0.266AsnCys: 0.266 ± 0.014	1.514AsnAsp: 1.514 ± 0.038	1.427AsnGlu: 1.427 ± 0.035	1.317AsnPhe: 1.317 ± 0.033	2.607AsnGly: 2.607 ± 0.057	0.651AsnHis: 0.651 ± 0.024	1.472AsnIle: 1.472 ± 0.039	0.927AsnLys: 0.927 ± 0.03	3.178AsnLeu: 3.178 ± 0.056	0.412AsnMet: 0.412 ± 0.019	1.126AsnAsn: 1.126 ± 0.036	2.283AsnPro: 2.283 ± 0.04	0.993AsnGln: 0.993 ± 0.032	1.853AsnArg: 1.853 ± 0.037	1.76AsnSer: 1.76 ± 0.04	1.887AsnThr: 1.887 ± 0.05	2.154AsnVal: 2.154 ± 0.048	0.514AsnTrp: 0.514 ± 0.022	0.98AsnTyr: 0.98 ± 0.028	0.0AsnXaa: 0.0 ± 0.0
Pro	7.438ProAla: 7.438 ± 0.098	0.313ProCys: 0.313 ± 0.016	3.064ProAsp: 3.064 ± 0.041	3.509ProGlu: 3.509 ± 0.059	2.061ProPhe: 2.061 ± 0.046	4.237ProGly: 4.237 ± 0.063	1.206ProHis: 1.206 ± 0.029	2.078ProIle: 2.078 ± 0.041	1.982ProLys: 1.982 ± 0.045	4.947ProLeu: 4.947 ± 0.069	0.999ProMet: 0.999 ± 0.027	1.323ProAsn: 1.323 ± 0.033	2.875ProPro: 2.875 ± 0.065	1.585ProGln: 1.585 ± 0.039	2.9ProArg: 2.9 ± 0.052	3.407ProSer: 3.407 ± 0.068	2.97ProThr: 2.97 ± 0.052	4.214ProVal: 4.214 ± 0.061	0.786ProTrp: 0.786 ± 0.024	1.104ProTyr: 1.104 ± 0.028	0.0ProXaa: 0.0 ± 0.0
Gln	3.354GlnAla: 3.354 ± 0.061	0.199GlnCys: 0.199 ± 0.011	1.157GlnAsp: 1.157 ± 0.029	1.52GlnGlu: 1.52 ± 0.039	1.248GlnPhe: 1.248 ± 0.033	1.96GlnGly: 1.96 ± 0.04	0.712GlnHis: 0.712 ± 0.023	1.932GlnIle: 1.932 ± 0.041	1.553GlnLys: 1.553 ± 0.041	3.769GlnLeu: 3.769 ± 0.061	0.667GlnMet: 0.667 ± 0.023	1.024GlnAsn: 1.024 ± 0.028	2.061GlnPro: 2.061 ± 0.042	1.321GlnGln: 1.321 ± 0.044	2.438GlnArg: 2.438 ± 0.047	1.997GlnSer: 1.997 ± 0.037	1.926GlnThr: 1.926 ± 0.039	1.97GlnVal: 1.97 ± 0.043	0.476GlnTrp: 0.476 ± 0.02	0.631GlnTyr: 0.631 ± 0.022	0.0GlnXaa: 0.0 ± 0.0
Arg	7.423ArgAla: 7.423 ± 0.083	0.543ArgCys: 0.543 ± 0.021	3.579ArgAsp: 3.579 ± 0.057	4.564ArgGlu: 4.564 ± 0.067	2.942ArgPhe: 2.942 ± 0.049	4.444ArgGly: 4.444 ± 0.064	1.606ArgHis: 1.606 ± 0.037	3.609ArgIle: 3.609 ± 0.052	2.455ArgLys: 2.455 ± 0.046	7.156ArgLeu: 7.156 ± 0.083	1.462ArgMet: 1.462 ± 0.034	1.835ArgAsn: 1.835 ± 0.039	3.201ArgPro: 3.201 ± 0.053	2.181ArgGln: 2.181 ± 0.039	4.691ArgArg: 4.691 ± 0.07	3.673ArgSer: 3.673 ± 0.052	3.664ArgThr: 3.664 ± 0.049	4.88ArgVal: 4.88 ± 0.062	1.192ArgTrp: 1.192 ± 0.034	1.83ArgTyr: 1.83 ± 0.038	0.0ArgXaa: 0.0 ± 0.0
Ser	7.445SerAla: 7.445 ± 0.096	0.429SerCys: 0.429 ± 0.019	2.949SerAsp: 2.949 ± 0.054	3.187SerGlu: 3.187 ± 0.056	2.516SerPhe: 2.516 ± 0.051	5.61SerGly: 5.61 ± 0.088	1.229SerHis: 1.229 ± 0.035	2.76SerIle: 2.76 ± 0.048	2.014SerLys: 2.014 ± 0.039	6.54SerLeu: 6.54 ± 0.081	1.128SerMet: 1.128 ± 0.027	1.638SerAsn: 1.638 ± 0.043	3.67SerPro: 3.67 ± 0.064	1.818SerGln: 1.818 ± 0.042	3.843SerArg: 3.843 ± 0.06	4.27SerSer: 4.27 ± 0.081	3.771SerThr: 3.771 ± 0.078	4.295SerVal: 4.295 ± 0.07	0.873SerTrp: 0.873 ± 0.026	1.544SerTyr: 1.544 ± 0.038	0.0SerXaa: 0.0 ± 0.0
Thr	7.333ThrAla: 7.333 ± 0.116	0.388ThrCys: 0.388 ± 0.018	3.133ThrAsp: 3.133 ± 0.06	2.952ThrGlu: 2.952 ± 0.053	2.451ThrPhe: 2.451 ± 0.047	5.512ThrGly: 5.512 ± 0.093	1.387ThrHis: 1.387 ± 0.033	2.916ThrIle: 2.916 ± 0.064	2.129ThrLys: 2.129 ± 0.045	6.879ThrLeu: 6.879 ± 0.086	0.876ThrMet: 0.876 ± 0.025	1.765ThrAsn: 1.765 ± 0.051	4.188ThrPro: 4.188 ± 0.071	1.882ThrGln: 1.882 ± 0.038	3.789ThrArg: 3.789 ± 0.056	3.767ThrSer: 3.767 ± 0.077	3.96ThrThr: 3.96 ± 0.087	4.461ThrVal: 4.461 ± 0.075	0.91ThrTrp: 0.91 ± 0.03	1.586ThrTyr: 1.586 ± 0.048	0.0ThrXaa: 0.0 ± 0.0
Val	7.87ValAla: 7.87 ± 0.094	0.733ValCys: 0.733 ± 0.022	3.213ValAsp: 3.213 ± 0.052	4.12ValGlu: 4.12 ± 0.07	3.08ValPhe: 3.08 ± 0.045	4.782ValGly: 4.782 ± 0.065	1.277ValHis: 1.277 ± 0.033	3.915ValIle: 3.915 ± 0.053	2.93ValLys: 2.93 ± 0.051	6.863ValLeu: 6.863 ± 0.078	1.358ValMet: 1.358 ± 0.037	2.207ValAsn: 2.207 ± 0.046	3.361ValPro: 3.361 ± 0.051	1.99ValGln: 1.99 ± 0.039	4.686ValArg: 4.686 ± 0.067	4.67ValSer: 4.67 ± 0.061	4.781ValThr: 4.781 ± 0.084	5.352ValVal: 5.352 ± 0.09	1.011ValTrp: 1.011 ± 0.028	1.551ValTyr: 1.551 ± 0.033	0.0ValXaa: 0.0 ± 0.0
Trp	1.294TrpAla: 1.294 ± 0.038	0.175TrpCys: 0.175 ± 0.012	0.73TrpAsp: 0.73 ± 0.026	0.765TrpGlu: 0.765 ± 0.027	0.68TrpPhe: 0.68 ± 0.021	0.897TrpGly: 0.897 ± 0.028	0.36TrpHis: 0.36 ± 0.015	0.805TrpIle: 0.805 ± 0.026	0.684TrpLys: 0.684 ± 0.025	1.856TrpLeu: 1.856 ± 0.047	0.365TrpMet: 0.365 ± 0.016	0.514TrpAsn: 0.514 ± 0.02	0.694TrpPro: 0.694 ± 0.024	0.621TrpGln: 0.621 ± 0.021	1.244TrpArg: 1.244 ± 0.034	1.039TrpSer: 1.039 ± 0.03	0.909TrpThr: 0.909 ± 0.028	0.921TrpVal: 0.921 ± 0.025	0.332TrpTrp: 0.332 ± 0.016	0.344TrpTyr: 0.344 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.582TyrAla: 2.582 ± 0.051	0.211TyrCys: 0.211 ± 0.012	1.474TyrAsp: 1.474 ± 0.037	1.274TyrGlu: 1.274 ± 0.033	1.172TyrPhe: 1.172 ± 0.026	1.897TyrGly: 1.897 ± 0.039	0.56TyrHis: 0.56 ± 0.023	0.889TyrIle: 0.889 ± 0.027	0.735TyrLys: 0.735 ± 0.027	2.439TyrLeu: 2.439 ± 0.043	0.346TyrMet: 0.346 ± 0.018	0.793TyrAsn: 0.793 ± 0.028	1.107TyrPro: 1.107 ± 0.031	0.943TyrGln: 0.943 ± 0.032	1.958TyrArg: 1.958 ± 0.042	1.419TyrSer: 1.419 ± 0.034	1.512TyrThr: 1.512 ± 0.042	1.588TyrVal: 1.588 ± 0.03	0.432TyrTrp: 0.432 ± 0.019	0.782TyrTyr: 0.782 ± 0.028	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3760 proteins (1409849 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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