Amino acid dipepetide frequency for Streptococcus phage Javan367

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.791AlaAla: 3.791 ± 1.002
0.441AlaCys: 0.441 ± 0.234
5.555AlaAsp: 5.555 ± 0.688
5.643AlaGlu: 5.643 ± 1.216
2.204AlaPhe: 2.204 ± 0.419
4.761AlaGly: 4.761 ± 1.201
0.617AlaHis: 0.617 ± 0.183
5.819AlaIle: 5.819 ± 0.803
7.318AlaLys: 7.318 ± 0.569
5.819AlaLeu: 5.819 ± 1.146
2.028AlaMet: 2.028 ± 0.425
3.35AlaAsn: 3.35 ± 0.745
1.323AlaPro: 1.323 ± 0.364
2.116AlaGln: 2.116 ± 0.401
2.645AlaArg: 2.645 ± 0.473
4.144AlaSer: 4.144 ± 0.887
3.791AlaThr: 3.791 ± 1.049
5.29AlaVal: 5.29 ± 0.917
0.97AlaTrp: 0.97 ± 0.229
3.439AlaTyr: 3.439 ± 0.541
0.0AlaXaa: 0.0 ± 0.0
Cys
0.353CysAla: 0.353 ± 0.231
0.176CysCys: 0.176 ± 0.128
0.265CysAsp: 0.265 ± 0.153
0.705CysGlu: 0.705 ± 0.334
0.441CysPhe: 0.441 ± 0.208
0.529CysGly: 0.529 ± 0.195
0.088CysHis: 0.088 ± 0.091
0.088CysIle: 0.088 ± 0.098
0.529CysLys: 0.529 ± 0.235
0.353CysLeu: 0.353 ± 0.183
0.176CysMet: 0.176 ± 0.12
0.176CysAsn: 0.176 ± 0.13
0.441CysPro: 0.441 ± 0.253
0.265CysGln: 0.265 ± 0.154
0.353CysArg: 0.353 ± 0.234
0.265CysSer: 0.265 ± 0.179
0.353CysThr: 0.353 ± 0.176
0.353CysVal: 0.353 ± 0.194
0.088CysTrp: 0.088 ± 0.093
0.529CysTyr: 0.529 ± 0.234
0.0CysXaa: 0.0 ± 0.0
Asp
3.703AspAla: 3.703 ± 0.516
0.705AspCys: 0.705 ± 0.242
4.32AspAsp: 4.32 ± 0.722
6.084AspGlu: 6.084 ± 0.838
3.615AspPhe: 3.615 ± 0.646
3.968AspGly: 3.968 ± 0.714
0.705AspHis: 0.705 ± 0.297
4.585AspIle: 4.585 ± 0.652
4.497AspLys: 4.497 ± 0.536
7.142AspLeu: 7.142 ± 0.974
2.204AspMet: 2.204 ± 0.411
3.439AspAsn: 3.439 ± 0.547
1.146AspPro: 1.146 ± 0.317
1.852AspGln: 1.852 ± 0.461
2.292AspArg: 2.292 ± 0.476
3.703AspSer: 3.703 ± 0.553
3.262AspThr: 3.262 ± 0.602
4.232AspVal: 4.232 ± 0.657
0.794AspTrp: 0.794 ± 0.303
2.557AspTyr: 2.557 ± 0.499
0.0AspXaa: 0.0 ± 0.0
Glu
7.23GluAla: 7.23 ± 1.071
0.529GluCys: 0.529 ± 0.218
3.968GluAsp: 3.968 ± 0.583
6.613GluGlu: 6.613 ± 0.924
3.35GluPhe: 3.35 ± 0.661
3.527GluGly: 3.527 ± 0.517
0.794GluHis: 0.794 ± 0.281
7.23GluIle: 7.23 ± 0.751
8.64GluLys: 8.64 ± 0.99
8.993GluLeu: 8.993 ± 0.964
2.292GluMet: 2.292 ± 0.498
4.408GluAsn: 4.408 ± 0.587
1.763GluPro: 1.763 ± 0.444
5.026GluGln: 5.026 ± 0.769
4.056GluArg: 4.056 ± 0.716
4.056GluSer: 4.056 ± 0.768
4.144GluThr: 4.144 ± 0.564
5.466GluVal: 5.466 ± 0.831
0.705GluTrp: 0.705 ± 0.247
2.116GluTyr: 2.116 ± 0.443
0.0GluXaa: 0.0 ± 0.0
Phe
2.469PheAla: 2.469 ± 0.346
0.265PheCys: 0.265 ± 0.149
3.527PheAsp: 3.527 ± 0.657
4.32PheGlu: 4.32 ± 0.781
1.763PhePhe: 1.763 ± 0.582
2.91PheGly: 2.91 ± 0.412
0.441PheHis: 0.441 ± 0.193
2.292PheIle: 2.292 ± 0.498
3.262PheLys: 3.262 ± 0.479
2.381PheLeu: 2.381 ± 0.341
1.146PheMet: 1.146 ± 0.286
1.058PheAsn: 1.058 ± 0.296
1.411PhePro: 1.411 ± 0.384
1.587PheGln: 1.587 ± 0.345
2.469PheArg: 2.469 ± 0.489
2.998PheSer: 2.998 ± 0.617
1.499PheThr: 1.499 ± 0.329
2.116PheVal: 2.116 ± 0.603
0.353PheTrp: 0.353 ± 0.177
1.411PheTyr: 1.411 ± 0.336
0.0PheXaa: 0.0 ± 0.0
Gly
3.262GlyAla: 3.262 ± 0.681
0.265GlyCys: 0.265 ± 0.141
2.998GlyAsp: 2.998 ± 0.604
4.32GlyGlu: 4.32 ± 0.634
2.821GlyPhe: 2.821 ± 0.407
3.086GlyGly: 3.086 ± 0.612
0.441GlyHis: 0.441 ± 0.193
4.232GlyIle: 4.232 ± 0.722
4.937GlyLys: 4.937 ± 0.609
5.202GlyLeu: 5.202 ± 1.06
1.323GlyMet: 1.323 ± 0.319
3.262GlyAsn: 3.262 ± 0.636
0.882GlyPro: 0.882 ± 0.268
2.733GlyGln: 2.733 ± 0.493
2.998GlyArg: 2.998 ± 0.388
4.673GlySer: 4.673 ± 0.967
2.91GlyThr: 2.91 ± 0.433
3.703GlyVal: 3.703 ± 0.564
1.323GlyTrp: 1.323 ± 0.502
2.733GlyTyr: 2.733 ± 0.501
0.0GlyXaa: 0.0 ± 0.0
His
1.058HisAla: 1.058 ± 0.327
0.176HisCys: 0.176 ± 0.116
1.146HisAsp: 1.146 ± 0.41
1.411HisGlu: 1.411 ± 0.389
0.617HisPhe: 0.617 ± 0.233
0.882HisGly: 0.882 ± 0.357
0.0HisHis: 0.0 ± 0.0
0.176HisIle: 0.176 ± 0.111
1.058HisLys: 1.058 ± 0.289
1.234HisLeu: 1.234 ± 0.292
0.176HisMet: 0.176 ± 0.126
0.794HisAsn: 0.794 ± 0.301
0.529HisPro: 0.529 ± 0.183
0.265HisGln: 0.265 ± 0.149
0.441HisArg: 0.441 ± 0.174
1.234HisSer: 1.234 ± 0.297
0.794HisThr: 0.794 ± 0.257
0.441HisVal: 0.441 ± 0.214
0.353HisTrp: 0.353 ± 0.208
0.441HisTyr: 0.441 ± 0.27
0.0HisXaa: 0.0 ± 0.0
Ile
4.32IleAla: 4.32 ± 0.569
0.441IleCys: 0.441 ± 0.228
5.378IleAsp: 5.378 ± 0.672
6.436IleGlu: 6.436 ± 0.842
1.587IlePhe: 1.587 ± 0.476
3.615IleGly: 3.615 ± 0.87
1.234IleHis: 1.234 ± 0.338
4.144IleIle: 4.144 ± 0.727
6.701IleLys: 6.701 ± 0.61
5.378IleLeu: 5.378 ± 0.808
1.411IleMet: 1.411 ± 0.343
3.703IleAsn: 3.703 ± 0.712
1.94IlePro: 1.94 ± 0.379
2.821IleGln: 2.821 ± 0.48
3.262IleArg: 3.262 ± 0.522
4.32IleSer: 4.32 ± 0.529
4.056IleThr: 4.056 ± 0.774
3.174IleVal: 3.174 ± 0.51
0.088IleTrp: 0.088 ± 0.078
2.292IleTyr: 2.292 ± 0.467
0.0IleXaa: 0.0 ± 0.0
Lys
7.494LysAla: 7.494 ± 1.257
0.088LysCys: 0.088 ± 0.075
5.555LysAsp: 5.555 ± 0.628
8.64LysGlu: 8.64 ± 0.813
3.439LysPhe: 3.439 ± 0.563
5.29LysGly: 5.29 ± 0.875
1.763LysHis: 1.763 ± 0.469
5.555LysIle: 5.555 ± 0.846
6.613LysLys: 6.613 ± 0.967
7.23LysLeu: 7.23 ± 0.9
2.469LysMet: 2.469 ± 0.421
5.466LysAsn: 5.466 ± 0.808
2.557LysPro: 2.557 ± 0.458
3.791LysGln: 3.791 ± 0.564
3.615LysArg: 3.615 ± 0.741
5.378LysSer: 5.378 ± 0.829
6.084LysThr: 6.084 ± 0.642
5.202LysVal: 5.202 ± 0.638
1.146LysTrp: 1.146 ± 0.289
3.086LysTyr: 3.086 ± 0.698
0.0LysXaa: 0.0 ± 0.0
Leu
6.436LeuAla: 6.436 ± 1.082
0.353LeuCys: 0.353 ± 0.176
6.613LeuAsp: 6.613 ± 0.672
7.494LeuGlu: 7.494 ± 1.109
2.998LeuPhe: 2.998 ± 0.651
5.026LeuGly: 5.026 ± 1.016
1.058LeuHis: 1.058 ± 0.365
4.497LeuIle: 4.497 ± 0.646
9.346LeuLys: 9.346 ± 1.274
5.819LeuLeu: 5.819 ± 0.689
1.499LeuMet: 1.499 ± 0.449
4.849LeuAsn: 4.849 ± 0.794
2.292LeuPro: 2.292 ± 0.548
3.439LeuGln: 3.439 ± 0.487
3.086LeuArg: 3.086 ± 0.671
5.202LeuSer: 5.202 ± 1.077
5.466LeuThr: 5.466 ± 0.826
4.761LeuVal: 4.761 ± 0.52
0.353LeuTrp: 0.353 ± 0.248
2.91LeuTyr: 2.91 ± 0.54
0.0LeuXaa: 0.0 ± 0.0
Met
2.821MetAla: 2.821 ± 0.572
0.088MetCys: 0.088 ± 0.102
1.94MetAsp: 1.94 ± 0.418
1.763MetGlu: 1.763 ± 0.408
1.234MetPhe: 1.234 ± 0.35
0.705MetGly: 0.705 ± 0.21
0.265MetHis: 0.265 ± 0.155
1.587MetIle: 1.587 ± 0.382
2.204MetLys: 2.204 ± 0.53
1.763MetLeu: 1.763 ± 0.347
0.441MetMet: 0.441 ± 0.17
1.763MetAsn: 1.763 ± 0.387
1.146MetPro: 1.146 ± 0.368
1.146MetGln: 1.146 ± 0.371
1.234MetArg: 1.234 ± 0.277
1.234MetSer: 1.234 ± 0.314
2.733MetThr: 2.733 ± 0.539
1.411MetVal: 1.411 ± 0.397
0.353MetTrp: 0.353 ± 0.153
1.058MetTyr: 1.058 ± 0.379
0.0MetXaa: 0.0 ± 0.0
Asn
4.408AsnAla: 4.408 ± 0.793
0.353AsnCys: 0.353 ± 0.182
2.91AsnAsp: 2.91 ± 0.39
4.232AsnGlu: 4.232 ± 0.76
2.204AsnPhe: 2.204 ± 0.361
4.232AsnGly: 4.232 ± 0.696
0.705AsnHis: 0.705 ± 0.215
2.821AsnIle: 2.821 ± 0.468
4.232AsnLys: 4.232 ± 0.677
3.879AsnLeu: 3.879 ± 0.502
1.499AsnMet: 1.499 ± 0.36
1.763AsnAsn: 1.763 ± 0.367
1.852AsnPro: 1.852 ± 0.482
3.439AsnGln: 3.439 ± 0.528
2.028AsnArg: 2.028 ± 0.404
2.733AsnSer: 2.733 ± 0.741
3.262AsnThr: 3.262 ± 0.566
2.998AsnVal: 2.998 ± 0.42
1.058AsnTrp: 1.058 ± 0.323
1.94AsnTyr: 1.94 ± 0.522
0.0AsnXaa: 0.0 ± 0.0
Pro
1.411ProAla: 1.411 ± 0.397
0.265ProCys: 0.265 ± 0.138
1.587ProAsp: 1.587 ± 0.43
2.821ProGlu: 2.821 ± 0.37
1.146ProPhe: 1.146 ± 0.257
1.234ProGly: 1.234 ± 0.365
0.353ProHis: 0.353 ± 0.186
2.381ProIle: 2.381 ± 0.392
2.469ProLys: 2.469 ± 0.556
2.028ProLeu: 2.028 ± 0.453
0.705ProMet: 0.705 ± 0.264
1.411ProAsn: 1.411 ± 0.411
0.617ProPro: 0.617 ± 0.191
0.705ProGln: 0.705 ± 0.207
1.234ProArg: 1.234 ± 0.479
1.411ProSer: 1.411 ± 0.383
1.852ProThr: 1.852 ± 0.445
1.587ProVal: 1.587 ± 0.382
0.088ProTrp: 0.088 ± 0.085
1.058ProTyr: 1.058 ± 0.484
0.0ProXaa: 0.0 ± 0.0
Gln
3.703GlnAla: 3.703 ± 0.534
0.353GlnCys: 0.353 ± 0.178
2.028GlnAsp: 2.028 ± 0.404
3.968GlnGlu: 3.968 ± 0.788
1.852GlnPhe: 1.852 ± 0.345
1.763GlnGly: 1.763 ± 0.4
0.617GlnHis: 0.617 ± 0.191
3.879GlnIle: 3.879 ± 0.542
4.144GlnLys: 4.144 ± 0.618
5.114GlnLeu: 5.114 ± 0.767
1.763GlnMet: 1.763 ± 0.397
2.733GlnAsn: 2.733 ± 0.5
0.882GlnPro: 0.882 ± 0.353
1.763GlnGln: 1.763 ± 0.402
1.675GlnArg: 1.675 ± 0.401
3.086GlnSer: 3.086 ± 0.482
1.675GlnThr: 1.675 ± 0.541
1.675GlnVal: 1.675 ± 0.416
0.617GlnTrp: 0.617 ± 0.33
1.146GlnTyr: 1.146 ± 0.342
0.0GlnXaa: 0.0 ± 0.0
Arg
2.381ArgAla: 2.381 ± 0.517
0.088ArgCys: 0.088 ± 0.09
2.292ArgAsp: 2.292 ± 0.571
3.703ArgGlu: 3.703 ± 0.585
1.499ArgPhe: 1.499 ± 0.365
1.763ArgGly: 1.763 ± 0.382
0.97ArgHis: 0.97 ± 0.305
3.174ArgIle: 3.174 ± 0.413
4.497ArgLys: 4.497 ± 0.951
3.791ArgLeu: 3.791 ± 0.527
1.499ArgMet: 1.499 ± 0.439
2.292ArgAsn: 2.292 ± 0.416
0.617ArgPro: 0.617 ± 0.34
2.645ArgGln: 2.645 ± 0.431
2.028ArgArg: 2.028 ± 0.44
2.821ArgSer: 2.821 ± 0.56
2.204ArgThr: 2.204 ± 0.452
2.381ArgVal: 2.381 ± 0.568
0.353ArgTrp: 0.353 ± 0.202
2.381ArgTyr: 2.381 ± 0.452
0.0ArgXaa: 0.0 ± 0.0
Ser
4.497SerAla: 4.497 ± 1.327
0.176SerCys: 0.176 ± 0.138
4.32SerAsp: 4.32 ± 0.575
4.849SerGlu: 4.849 ± 0.683
2.557SerPhe: 2.557 ± 0.442
4.232SerGly: 4.232 ± 0.511
0.882SerHis: 0.882 ± 0.274
3.262SerIle: 3.262 ± 0.483
4.849SerLys: 4.849 ± 0.523
4.761SerLeu: 4.761 ± 0.654
2.292SerMet: 2.292 ± 0.579
3.086SerAsn: 3.086 ± 0.515
2.028SerPro: 2.028 ± 0.472
3.615SerGln: 3.615 ± 0.601
1.852SerArg: 1.852 ± 0.327
4.056SerSer: 4.056 ± 0.691
2.733SerThr: 2.733 ± 0.541
3.35SerVal: 3.35 ± 0.721
0.794SerTrp: 0.794 ± 0.333
3.527SerTyr: 3.527 ± 0.453
0.0SerXaa: 0.0 ± 0.0
Thr
4.673ThrAla: 4.673 ± 1.396
0.441ThrCys: 0.441 ± 0.243
3.703ThrAsp: 3.703 ± 0.61
2.821ThrGlu: 2.821 ± 0.588
1.94ThrPhe: 1.94 ± 0.479
4.408ThrGly: 4.408 ± 0.681
0.617ThrHis: 0.617 ± 0.275
4.849ThrIle: 4.849 ± 0.759
5.29ThrLys: 5.29 ± 0.739
4.32ThrLeu: 4.32 ± 0.581
1.323ThrMet: 1.323 ± 0.354
3.262ThrAsn: 3.262 ± 0.647
2.292ThrPro: 2.292 ± 0.373
1.763ThrGln: 1.763 ± 0.35
2.116ThrArg: 2.116 ± 0.449
3.262ThrSer: 3.262 ± 0.571
3.439ThrThr: 3.439 ± 0.656
3.527ThrVal: 3.527 ± 0.587
0.705ThrTrp: 0.705 ± 0.321
1.94ThrTyr: 1.94 ± 0.429
0.0ThrXaa: 0.0 ± 0.0
Val
4.232ValAla: 4.232 ± 0.955
0.265ValCys: 0.265 ± 0.178
3.968ValAsp: 3.968 ± 0.562
5.202ValGlu: 5.202 ± 0.592
1.852ValPhe: 1.852 ± 0.554
3.527ValGly: 3.527 ± 0.528
0.617ValHis: 0.617 ± 0.337
3.615ValIle: 3.615 ± 0.697
5.29ValLys: 5.29 ± 0.596
4.232ValLeu: 4.232 ± 0.634
1.763ValMet: 1.763 ± 0.338
3.35ValAsn: 3.35 ± 0.528
1.234ValPro: 1.234 ± 0.371
2.204ValGln: 2.204 ± 0.488
3.262ValArg: 3.262 ± 0.617
4.32ValSer: 4.32 ± 0.613
4.232ValThr: 4.232 ± 0.786
4.408ValVal: 4.408 ± 0.691
0.353ValTrp: 0.353 ± 0.207
1.675ValTyr: 1.675 ± 0.392
0.0ValXaa: 0.0 ± 0.0
Trp
0.794TrpAla: 0.794 ± 0.234
0.265TrpCys: 0.265 ± 0.17
0.617TrpAsp: 0.617 ± 0.259
0.705TrpGlu: 0.705 ± 0.208
0.353TrpPhe: 0.353 ± 0.147
0.705TrpGly: 0.705 ± 0.281
0.265TrpHis: 0.265 ± 0.139
0.353TrpIle: 0.353 ± 0.14
1.234TrpLys: 1.234 ± 0.293
0.97TrpLeu: 0.97 ± 0.274
0.088TrpMet: 0.088 ± 0.09
0.529TrpAsn: 0.529 ± 0.325
0.265TrpPro: 0.265 ± 0.162
0.441TrpGln: 0.441 ± 0.204
0.882TrpArg: 0.882 ± 0.32
0.794TrpSer: 0.794 ± 0.291
0.353TrpThr: 0.353 ± 0.173
0.97TrpVal: 0.97 ± 0.299
0.088TrpTrp: 0.088 ± 0.095
0.705TrpTyr: 0.705 ± 0.497
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.028TyrAla: 2.028 ± 0.433
0.794TyrCys: 0.794 ± 0.245
2.116TyrAsp: 2.116 ± 0.431
3.174TyrGlu: 3.174 ± 0.421
2.204TyrPhe: 2.204 ± 0.412
1.94TyrGly: 1.94 ± 0.339
0.794TyrHis: 0.794 ± 0.262
1.763TyrIle: 1.763 ± 0.421
3.439TyrLys: 3.439 ± 0.584
3.086TyrLeu: 3.086 ± 0.484
0.705TyrMet: 0.705 ± 0.33
1.852TyrAsn: 1.852 ± 0.405
1.146TyrPro: 1.146 ± 0.356
2.821TyrGln: 2.821 ± 0.371
1.852TyrArg: 1.852 ± 0.45
2.028TyrSer: 2.028 ± 0.351
1.852TyrThr: 1.852 ± 0.549
2.557TyrVal: 2.557 ± 0.577
0.794TyrTrp: 0.794 ± 0.311
1.499TyrTyr: 1.499 ± 0.698
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 54 proteins (11343 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski