Amino acid dipepetide frequency for endosymbiont of Galathealinum brachiosum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.302AlaAla: 6.302 ± 0.112	0.893AlaCys: 0.893 ± 0.028	4.525AlaAsp: 4.525 ± 0.074	5.055AlaGlu: 5.055 ± 0.072	2.94AlaPhe: 2.94 ± 0.056	5.651AlaGly: 5.651 ± 0.133	1.457AlaHis: 1.457 ± 0.039	5.545AlaIle: 5.545 ± 0.072	3.996AlaLys: 3.996 ± 0.07	7.716AlaLeu: 7.716 ± 0.103	2.249AlaMet: 2.249 ± 0.049	3.282AlaAsn: 3.282 ± 0.067	2.328AlaPro: 2.328 ± 0.064	2.63AlaGln: 2.63 ± 0.053	3.406AlaArg: 3.406 ± 0.056	4.935AlaSer: 4.935 ± 0.077	3.768AlaThr: 3.768 ± 0.069	5.141AlaVal: 5.141 ± 0.084	0.781AlaTrp: 0.781 ± 0.028	2.222AlaTyr: 2.222 ± 0.047	0.0AlaXaa: 0.0 ± 0.0
Cys	0.648CysAla: 0.648 ± 0.028	0.155CysCys: 0.155 ± 0.015	0.613CysAsp: 0.613 ± 0.026	0.594CysGlu: 0.594 ± 0.022	0.38CysPhe: 0.38 ± 0.019	0.874CysGly: 0.874 ± 0.035	0.406CysHis: 0.406 ± 0.037	0.647CysIle: 0.647 ± 0.025	0.548CysLys: 0.548 ± 0.025	0.881CysLeu: 0.881 ± 0.033	0.233CysMet: 0.233 ± 0.015	0.47CysAsn: 0.47 ± 0.023	0.48CysPro: 0.48 ± 0.022	0.326CysGln: 0.326 ± 0.018	0.404CysArg: 0.404 ± 0.018	0.669CysSer: 0.669 ± 0.023	0.472CysThr: 0.472 ± 0.022	0.615CysVal: 0.615 ± 0.027	0.105CysTrp: 0.105 ± 0.009	0.284CysTyr: 0.284 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	4.424AspAla: 4.424 ± 0.066	0.534AspCys: 0.534 ± 0.023	3.987AspAsp: 3.987 ± 0.071	4.55AspGlu: 4.55 ± 0.069	2.678AspPhe: 2.678 ± 0.052	3.998AspGly: 3.998 ± 0.103	1.12AspHis: 1.12 ± 0.033	4.926AspIle: 4.926 ± 0.074	3.862AspLys: 3.862 ± 0.076	5.636AspLeu: 5.636 ± 0.085	1.578AspMet: 1.578 ± 0.041	3.069AspAsn: 3.069 ± 0.067	2.044AspPro: 2.044 ± 0.05	2.098AspGln: 2.098 ± 0.042	2.336AspArg: 2.336 ± 0.049	3.869AspSer: 3.869 ± 0.065	3.083AspThr: 3.083 ± 0.067	4.244AspVal: 4.244 ± 0.081	0.773AspTrp: 0.773 ± 0.028	2.131AspTyr: 2.131 ± 0.046	0.0AspXaa: 0.0 ± 0.0
Glu	4.657GluAla: 4.657 ± 0.093	0.508GluCys: 0.508 ± 0.022	3.379GluAsp: 3.379 ± 0.065	4.133GluGlu: 4.133 ± 0.084	2.564GluPhe: 2.564 ± 0.055	3.479GluGly: 3.479 ± 0.061	1.401GluHis: 1.401 ± 0.04	4.985GluIle: 4.985 ± 0.075	4.718GluLys: 4.718 ± 0.095	6.924GluLeu: 6.924 ± 0.084	1.845GluMet: 1.845 ± 0.044	3.567GluAsn: 3.567 ± 0.059	1.817GluPro: 1.817 ± 0.048	2.906GluGln: 2.906 ± 0.062	2.685GluArg: 2.685 ± 0.061	4.094GluSer: 4.094 ± 0.075	3.49GluThr: 3.49 ± 0.063	4.092GluVal: 4.092 ± 0.063	0.692GluTrp: 0.692 ± 0.023	2.062GluTyr: 2.062 ± 0.042	0.0GluXaa: 0.0 ± 0.0
Phe	2.706PheAla: 2.706 ± 0.056	0.422PheCys: 0.422 ± 0.022	2.868PheAsp: 2.868 ± 0.064	2.595PheGlu: 2.595 ± 0.052	1.787PhePhe: 1.787 ± 0.043	2.668PheGly: 2.668 ± 0.061	0.794PheHis: 0.794 ± 0.029	3.353PheIle: 3.353 ± 0.056	2.472PheLys: 2.472 ± 0.052	3.445PheLeu: 3.445 ± 0.061	1.11PheMet: 1.11 ± 0.037	2.431PheAsn: 2.431 ± 0.053	1.337PhePro: 1.337 ± 0.036	1.165PheGln: 1.165 ± 0.036	1.428PheArg: 1.428 ± 0.034	3.475PheSer: 3.475 ± 0.065	2.461PheThr: 2.461 ± 0.061	2.477PheVal: 2.477 ± 0.055	0.472PheTrp: 0.472 ± 0.019	1.397PheTyr: 1.397 ± 0.037	0.0PheXaa: 0.0 ± 0.0
Gly	4.657GlyAla: 4.657 ± 0.118	0.794GlyCys: 0.794 ± 0.028	3.917GlyAsp: 3.917 ± 0.092	4.061GlyGlu: 4.061 ± 0.062	3.257GlyPhe: 3.257 ± 0.064	4.686GlyGly: 4.686 ± 0.105	1.427GlyHis: 1.427 ± 0.038	4.789GlyIle: 4.789 ± 0.075	4.113GlyLys: 4.113 ± 0.072	6.481GlyLeu: 6.481 ± 0.086	1.953GlyMet: 1.953 ± 0.051	2.915GlyAsn: 2.915 ± 0.076	1.651GlyPro: 1.651 ± 0.044	2.214GlyGln: 2.214 ± 0.047	2.806GlyArg: 2.806 ± 0.054	4.336GlySer: 4.336 ± 0.087	3.32GlyThr: 3.32 ± 0.084	4.859GlyVal: 4.859 ± 0.085	0.862GlyTrp: 0.862 ± 0.03	2.425GlyTyr: 2.425 ± 0.058	0.0GlyXaa: 0.0 ± 0.0
His	1.534HisAla: 1.534 ± 0.033	0.255HisCys: 0.255 ± 0.017	1.234HisAsp: 1.234 ± 0.031	1.309HisGlu: 1.309 ± 0.034	0.952HisPhe: 0.952 ± 0.031	1.441HisGly: 1.441 ± 0.034	0.622HisHis: 0.622 ± 0.029	1.49HisIle: 1.49 ± 0.036	1.27HisLys: 1.27 ± 0.041	2.155HisLeu: 2.155 ± 0.045	0.604HisMet: 0.604 ± 0.022	1.079HisAsn: 1.079 ± 0.032	1.047HisPro: 1.047 ± 0.036	1.0HisGln: 1.0 ± 0.034	0.944HisArg: 0.944 ± 0.033	1.422HisSer: 1.422 ± 0.037	1.021HisThr: 1.021 ± 0.027	1.222HisVal: 1.222 ± 0.032	0.29HisTrp: 0.29 ± 0.017	0.78HisTyr: 0.78 ± 0.031	0.0HisXaa: 0.0 ± 0.0
Ile	5.626IleAla: 5.626 ± 0.078	0.689IleCys: 0.689 ± 0.027	5.109IleAsp: 5.109 ± 0.076	5.328IleGlu: 5.328 ± 0.085	2.678IlePhe: 2.678 ± 0.057	4.408IleGly: 4.408 ± 0.073	1.497IleHis: 1.497 ± 0.04	5.312IleIle: 5.312 ± 0.088	5.036IleLys: 5.036 ± 0.084	6.398IleLeu: 6.398 ± 0.079	1.59IleMet: 1.59 ± 0.039	4.621IleAsn: 4.621 ± 0.067	2.892IlePro: 2.892 ± 0.052	2.58IleGln: 2.58 ± 0.048	3.006IleArg: 3.006 ± 0.058	5.761IleSer: 5.761 ± 0.084	4.539IleThr: 4.539 ± 0.076	4.134IleVal: 4.134 ± 0.068	0.667IleTrp: 0.667 ± 0.028	2.107IleTyr: 2.107 ± 0.049	0.0IleXaa: 0.0 ± 0.0
Lys	4.498LysAla: 4.498 ± 0.077	0.417LysCys: 0.417 ± 0.026	3.31LysAsp: 3.31 ± 0.066	3.708LysGlu: 3.708 ± 0.068	1.831LysPhe: 1.831 ± 0.041	3.455LysGly: 3.455 ± 0.062	1.529LysHis: 1.529 ± 0.043	4.646LysIle: 4.646 ± 0.082	4.713LysLys: 4.713 ± 0.139	6.055LysLeu: 6.055 ± 0.098	1.66LysMet: 1.66 ± 0.039	3.577LysAsn: 3.577 ± 0.068	2.554LysPro: 2.554 ± 0.057	3.152LysGln: 3.152 ± 0.06	2.766LysArg: 2.766 ± 0.059	4.155LysSer: 4.155 ± 0.074	3.599LysThr: 3.599 ± 0.067	3.628LysVal: 3.628 ± 0.075	0.546LysTrp: 0.546 ± 0.022	1.813LysTyr: 1.813 ± 0.051	0.0LysXaa: 0.0 ± 0.0
Leu	7.536LeuAla: 7.536 ± 0.109	0.924LeuCys: 0.924 ± 0.032	5.955LeuAsp: 5.955 ± 0.082	5.98LeuGlu: 5.98 ± 0.087	4.287LeuPhe: 4.287 ± 0.057	6.092LeuGly: 6.092 ± 0.081	2.063LeuHis: 2.063 ± 0.056	7.375LeuIle: 7.375 ± 0.093	6.403LeuLys: 6.403 ± 0.088	10.134LeuLeu: 10.134 ± 0.131	2.663LeuMet: 2.663 ± 0.052	5.498LeuAsn: 5.498 ± 0.087	4.023LeuPro: 4.023 ± 0.073	3.853LeuGln: 3.853 ± 0.067	4.115LeuArg: 4.115 ± 0.065	7.976LeuSer: 7.976 ± 0.098	5.437LeuThr: 5.437 ± 0.077	6.03LeuVal: 6.03 ± 0.082	0.898LeuTrp: 0.898 ± 0.031	2.72LeuTyr: 2.72 ± 0.056	0.0LeuXaa: 0.0 ± 0.0
Met	2.126MetAla: 2.126 ± 0.05	0.22MetCys: 0.22 ± 0.013	1.481MetAsp: 1.481 ± 0.036	1.375MetGlu: 1.375 ± 0.042	0.982MetPhe: 0.982 ± 0.033	1.814MetGly: 1.814 ± 0.047	0.605MetHis: 0.605 ± 0.027	1.661MetIle: 1.661 ± 0.04	1.682MetLys: 1.682 ± 0.038	2.856MetLeu: 2.856 ± 0.061	0.775MetMet: 0.775 ± 0.032	1.299MetAsn: 1.299 ± 0.034	1.334MetPro: 1.334 ± 0.038	1.24MetGln: 1.24 ± 0.035	1.169MetArg: 1.169 ± 0.034	2.174MetSer: 2.174 ± 0.055	1.374MetThr: 1.374 ± 0.038	1.633MetVal: 1.633 ± 0.044	0.182MetTrp: 0.182 ± 0.014	0.566MetTyr: 0.566 ± 0.025	0.0MetXaa: 0.0 ± 0.0
Asn	3.575AsnAla: 3.575 ± 0.067	0.486AsnCys: 0.486 ± 0.02	2.97AsnAsp: 2.97 ± 0.069	3.181AsnGlu: 3.181 ± 0.056	1.758AsnPhe: 1.758 ± 0.042	3.155AsnGly: 3.155 ± 0.083	1.161AsnHis: 1.161 ± 0.032	4.237AsnIle: 4.237 ± 0.068	3.686AsnLys: 3.686 ± 0.066	4.608AsnLeu: 4.608 ± 0.073	1.254AsnMet: 1.254 ± 0.036	3.257AsnAsn: 3.257 ± 0.082	2.119AsnPro: 2.119 ± 0.044	2.195AsnGln: 2.195 ± 0.044	2.251AsnArg: 2.251 ± 0.049	3.365AsnSer: 3.365 ± 0.07	2.882AsnThr: 2.882 ± 0.064	2.916AsnVal: 2.916 ± 0.065	0.661AsnTrp: 0.661 ± 0.025	1.579AsnTyr: 1.579 ± 0.039	0.0AsnXaa: 0.0 ± 0.0
Pro	2.952ProAla: 2.952 ± 0.063	0.313ProCys: 0.313 ± 0.015	2.845ProAsp: 2.845 ± 0.053	3.191ProGlu: 3.191 ± 0.065	1.541ProPhe: 1.541 ± 0.04	2.696ProGly: 2.696 ± 0.053	0.709ProHis: 0.709 ± 0.024	2.097ProIle: 2.097 ± 0.046	1.671ProLys: 1.671 ± 0.053	3.461ProLeu: 3.461 ± 0.06	0.931ProMet: 0.931 ± 0.031	1.326ProAsn: 1.326 ± 0.037	1.134ProPro: 1.134 ± 0.041	1.259ProGln: 1.259 ± 0.035	1.233ProArg: 1.233 ± 0.041	2.011ProSer: 2.011 ± 0.047	1.684ProThr: 1.684 ± 0.043	3.633ProVal: 3.633 ± 0.07	0.442ProTrp: 0.442 ± 0.019	1.105ProTyr: 1.105 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	3.324GlnAla: 3.324 ± 0.052	0.349GlnCys: 0.349 ± 0.019	1.825GlnAsp: 1.825 ± 0.044	1.902GlnGlu: 1.902 ± 0.042	1.492GlnPhe: 1.492 ± 0.043	2.432GlnGly: 2.432 ± 0.048	0.984GlnHis: 0.984 ± 0.031	2.698GlnIle: 2.698 ± 0.055	2.253GlnLys: 2.253 ± 0.052	4.513GlnLeu: 4.513 ± 0.08	1.026GlnMet: 1.026 ± 0.032	1.857GlnAsn: 1.857 ± 0.042	1.388GlnPro: 1.388 ± 0.035	2.512GlnGln: 2.512 ± 0.07	1.916GlnArg: 1.916 ± 0.05	2.651GlnSer: 2.651 ± 0.054	1.965GlnThr: 1.965 ± 0.047	2.635GlnVal: 2.635 ± 0.051	0.466GlnTrp: 0.466 ± 0.022	1.192GlnTyr: 1.192 ± 0.035	0.001GlnXaa: 0.001 ± 0.001
Arg	2.843ArgAla: 2.843 ± 0.057	0.414ArgCys: 0.414 ± 0.022	2.461ArgAsp: 2.461 ± 0.043	2.81ArgGlu: 2.81 ± 0.061	1.979ArgPhe: 1.979 ± 0.044	2.344ArgGly: 2.344 ± 0.045	1.001ArgHis: 1.001 ± 0.028	3.174ArgIle: 3.174 ± 0.057	2.643ArgLys: 2.643 ± 0.051	4.671ArgLeu: 4.671 ± 0.071	1.232ArgMet: 1.232 ± 0.037	2.021ArgAsn: 2.021 ± 0.043	1.426ArgPro: 1.426 ± 0.042	1.736ArgGln: 1.736 ± 0.036	1.996ArgArg: 1.996 ± 0.054	2.585ArgSer: 2.585 ± 0.063	1.959ArgThr: 1.959 ± 0.045	2.802ArgVal: 2.802 ± 0.054	0.547ArgTrp: 0.547 ± 0.024	1.635ArgTyr: 1.635 ± 0.038	0.0ArgXaa: 0.0 ± 0.0
Ser	5.3SerAla: 5.3 ± 0.073	0.81SerCys: 0.81 ± 0.028	4.276SerAsp: 4.276 ± 0.065	4.302SerGlu: 4.302 ± 0.073	2.968SerPhe: 2.968 ± 0.063	5.392SerGly: 5.392 ± 0.088	1.544SerHis: 1.544 ± 0.047	5.345SerIle: 5.345 ± 0.087	3.607SerLys: 3.607 ± 0.071	7.296SerLeu: 7.296 ± 0.09	1.864SerMet: 1.864 ± 0.043	3.375SerAsn: 3.375 ± 0.069	2.326SerPro: 2.326 ± 0.051	2.598SerGln: 2.598 ± 0.05	3.007SerArg: 3.007 ± 0.054	5.18SerSer: 5.18 ± 0.084	3.586SerThr: 3.586 ± 0.072	4.718SerVal: 4.718 ± 0.073	0.713SerTrp: 0.713 ± 0.027	2.096SerTyr: 2.096 ± 0.049	0.001SerXaa: 0.001 ± 0.001
Thr	4.207ThrAla: 4.207 ± 0.075	0.495ThrCys: 0.495 ± 0.023	3.551ThrAsp: 3.551 ± 0.076	3.375ThrGlu: 3.375 ± 0.061	1.96ThrPhe: 1.96 ± 0.051	4.526ThrGly: 4.526 ± 0.094	1.195ThrHis: 1.195 ± 0.034	3.665ThrIle: 3.665 ± 0.076	2.469ThrLys: 2.469 ± 0.046	5.613ThrLeu: 5.613 ± 0.075	1.088ThrMet: 1.088 ± 0.037	2.291ThrAsn: 2.291 ± 0.059	2.444ThrPro: 2.444 ± 0.05	2.028ThrGln: 2.028 ± 0.046	2.211ThrArg: 2.211 ± 0.046	3.65ThrSer: 3.65 ± 0.071	2.844ThrThr: 2.844 ± 0.064	3.67ThrVal: 3.67 ± 0.071	0.461ThrTrp: 0.461 ± 0.022	1.57ThrTyr: 1.57 ± 0.036	0.0ThrXaa: 0.0 ± 0.0
Val	5.012ValAla: 5.012 ± 0.079	0.671ValCys: 0.671 ± 0.026	4.285ValAsp: 4.285 ± 0.071	4.256ValGlu: 4.256 ± 0.074	2.858ValPhe: 2.858 ± 0.058	3.802ValGly: 3.802 ± 0.084	1.218ValHis: 1.218 ± 0.031	5.274ValIle: 5.274 ± 0.077	3.903ValLys: 3.903 ± 0.067	6.51ValLeu: 6.51 ± 0.076	1.859ValMet: 1.859 ± 0.05	3.318ValAsn: 3.318 ± 0.064	2.25ValPro: 2.25 ± 0.058	1.865ValGln: 1.865 ± 0.046	2.597ValArg: 2.597 ± 0.057	4.983ValSer: 4.983 ± 0.075	3.73ValThr: 3.73 ± 0.075	4.722ValVal: 4.722 ± 0.08	0.636ValTrp: 0.636 ± 0.026	1.938ValTyr: 1.938 ± 0.054	0.0ValXaa: 0.0 ± 0.0
Trp	0.68TrpAla: 0.68 ± 0.025	0.13TrpCys: 0.13 ± 0.012	0.594TrpAsp: 0.594 ± 0.021	0.528TrpGlu: 0.528 ± 0.023	0.539TrpPhe: 0.539 ± 0.02	0.627TrpGly: 0.627 ± 0.024	0.243TrpHis: 0.243 ± 0.015	0.683TrpIle: 0.683 ± 0.026	0.614TrpLys: 0.614 ± 0.026	1.417TrpLeu: 1.417 ± 0.044	0.328TrpMet: 0.328 ± 0.015	0.508TrpAsn: 0.508 ± 0.023	0.386TrpPro: 0.386 ± 0.02	0.554TrpGln: 0.554 ± 0.023	0.534TrpArg: 0.534 ± 0.022	0.718TrpSer: 0.718 ± 0.028	0.433TrpThr: 0.433 ± 0.02	0.761TrpVal: 0.761 ± 0.031	0.165TrpTrp: 0.165 ± 0.013	0.322TrpTyr: 0.322 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.211TyrAla: 2.211 ± 0.048	0.328TyrCys: 0.328 ± 0.016	1.755TyrAsp: 1.755 ± 0.043	1.764TyrGlu: 1.764 ± 0.04	1.432TyrPhe: 1.432 ± 0.038	1.98TyrGly: 1.98 ± 0.044	0.693TyrHis: 0.693 ± 0.025	2.078TyrIle: 2.078 ± 0.043	1.951TyrLys: 1.951 ± 0.046	3.192TyrLeu: 3.192 ± 0.057	0.709TyrMet: 0.709 ± 0.027	1.536TyrAsn: 1.536 ± 0.042	1.251TyrPro: 1.251 ± 0.037	1.473TyrGln: 1.473 ± 0.031	1.472TyrArg: 1.472 ± 0.04	2.291TyrSer: 2.291 ± 0.057	1.665TyrThr: 1.665 ± 0.042	1.757TyrVal: 1.757 ± 0.043	0.407TyrTrp: 0.407 ± 0.019	1.064TyrTyr: 1.064 ± 0.033	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.001XaaAla: 0.001 ± 0.001	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.001XaaPro: 0.001 ± 0.001	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3414 proteins (1105146 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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