Amino acid dipepetide frequency for Pantoea sp. Aalb

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.639AlaAla: 4.639 ± 0.17
0.872AlaCys: 0.872 ± 0.053
2.544AlaAsp: 2.544 ± 0.09
3.219AlaGlu: 3.219 ± 0.123
2.202AlaPhe: 2.202 ± 0.09
3.971AlaGly: 3.971 ± 0.138
1.282AlaHis: 1.282 ± 0.061
6.618AlaIle: 6.618 ± 0.16
3.816AlaLys: 3.816 ± 0.118
7.066AlaLeu: 7.066 ± 0.178
1.834AlaMet: 1.834 ± 0.081
3.161AlaAsn: 3.161 ± 0.119
1.775AlaPro: 1.775 ± 0.083
2.289AlaGln: 2.289 ± 0.084
3.088AlaArg: 3.088 ± 0.114
3.688AlaSer: 3.688 ± 0.115
3.019AlaThr: 3.019 ± 0.107
3.592AlaVal: 3.592 ± 0.115
0.762AlaTrp: 0.762 ± 0.048
1.965AlaTyr: 1.965 ± 0.084
0.0AlaXaa: 0.0 ± 0.0
Cys
0.745CysAla: 0.745 ± 0.052
0.196CysCys: 0.196 ± 0.03
0.679CysAsp: 0.679 ± 0.052
0.551CysGlu: 0.551 ± 0.04
0.576CysPhe: 0.576 ± 0.041
1.031CysGly: 1.031 ± 0.064
0.414CysHis: 0.414 ± 0.042
1.303CysIle: 1.303 ± 0.081
0.672CysLys: 0.672 ± 0.055
1.293CysLeu: 1.293 ± 0.064
0.286CysMet: 0.286 ± 0.033
0.796CysAsn: 0.796 ± 0.046
0.486CysPro: 0.486 ± 0.043
0.455CysGln: 0.455 ± 0.037
0.52CysArg: 0.52 ± 0.042
0.9CysSer: 0.9 ± 0.059
0.631CysThr: 0.631 ± 0.051
0.555CysVal: 0.555 ± 0.044
0.196CysTrp: 0.196 ± 0.026
0.496CysTyr: 0.496 ± 0.043
0.0CysXaa: 0.0 ± 0.0
Asp
2.713AspAla: 2.713 ± 0.103
0.555AspCys: 0.555 ± 0.044
1.847AspAsp: 1.847 ± 0.086
2.495AspGlu: 2.495 ± 0.131
2.14AspPhe: 2.14 ± 0.094
2.571AspGly: 2.571 ± 0.09
0.996AspHis: 0.996 ± 0.069
5.263AspIle: 5.263 ± 0.141
2.94AspLys: 2.94 ± 0.092
4.546AspLeu: 4.546 ± 0.119
1.137AspMet: 1.137 ± 0.063
2.578AspAsn: 2.578 ± 0.099
1.527AspPro: 1.527 ± 0.074
1.351AspGln: 1.351 ± 0.071
2.027AspArg: 2.027 ± 0.097
2.568AspSer: 2.568 ± 0.092
2.075AspThr: 2.075 ± 0.082
2.723AspVal: 2.723 ± 0.12
0.596AspTrp: 0.596 ± 0.046
1.81AspTyr: 1.81 ± 0.076
0.0AspXaa: 0.0 ± 0.0
Glu
3.43GluAla: 3.43 ± 0.116
0.551GluCys: 0.551 ± 0.048
2.189GluAsp: 2.189 ± 0.093
2.926GluGlu: 2.926 ± 0.125
1.951GluPhe: 1.951 ± 0.078
2.688GluGly: 2.688 ± 0.108
1.32GluHis: 1.32 ± 0.069
5.36GluIle: 5.36 ± 0.151
4.081GluLys: 4.081 ± 0.154
6.001GluLeu: 6.001 ± 0.169
1.472GluMet: 1.472 ± 0.065
2.806GluAsn: 2.806 ± 0.109
1.437GluPro: 1.437 ± 0.078
2.495GluGln: 2.495 ± 0.117
2.937GluArg: 2.937 ± 0.118
2.737GluSer: 2.737 ± 0.102
2.244GluThr: 2.244 ± 0.096
3.495GluVal: 3.495 ± 0.129
0.476GluTrp: 0.476 ± 0.042
1.682GluTyr: 1.682 ± 0.087
0.0GluXaa: 0.0 ± 0.0
Phe
2.182PheAla: 2.182 ± 0.09
0.686PheCys: 0.686 ± 0.047
2.154PheAsp: 2.154 ± 0.09
1.834PheGlu: 1.834 ± 0.081
2.085PhePhe: 2.085 ± 0.097
2.937PheGly: 2.937 ± 0.095
1.044PheHis: 1.044 ± 0.055
4.805PheIle: 4.805 ± 0.141
2.495PheLys: 2.495 ± 0.098
3.726PheLeu: 3.726 ± 0.123
1.051PheMet: 1.051 ± 0.059
3.109PheAsn: 3.109 ± 0.112
1.537PhePro: 1.537 ± 0.065
1.317PheGln: 1.317 ± 0.071
1.61PheArg: 1.61 ± 0.08
3.336PheSer: 3.336 ± 0.108
2.223PheThr: 2.223 ± 0.087
1.827PheVal: 1.827 ± 0.097
0.531PheTrp: 0.531 ± 0.049
1.63PheTyr: 1.63 ± 0.083
0.0PheXaa: 0.0 ± 0.0
Gly
3.709GlyAla: 3.709 ± 0.131
1.089GlyCys: 1.089 ± 0.065
2.592GlyAsp: 2.592 ± 0.104
2.992GlyGlu: 2.992 ± 0.116
2.864GlyPhe: 2.864 ± 0.108
4.005GlyGly: 4.005 ± 0.154
1.589GlyHis: 1.589 ± 0.077
7.09GlyIle: 7.09 ± 0.191
4.533GlyLys: 4.533 ± 0.122
5.853GlyLeu: 5.853 ± 0.148
1.637GlyMet: 1.637 ± 0.073
3.237GlyAsn: 3.237 ± 0.114
1.682GlyPro: 1.682 ± 0.082
2.199GlyGln: 2.199 ± 0.091
3.095GlyArg: 3.095 ± 0.127
3.474GlySer: 3.474 ± 0.118
3.099GlyThr: 3.099 ± 0.11
3.571GlyVal: 3.571 ± 0.112
0.762GlyTrp: 0.762 ± 0.051
2.402GlyTyr: 2.402 ± 0.093
0.0GlyXaa: 0.0 ± 0.0
His
1.503HisAla: 1.503 ± 0.074
0.369HisCys: 0.369 ± 0.035
0.996HisAsp: 0.996 ± 0.062
1.017HisGlu: 1.017 ± 0.059
1.227HisPhe: 1.227 ± 0.066
1.689HisGly: 1.689 ± 0.081
0.807HisHis: 0.807 ± 0.057
2.495HisIle: 2.495 ± 0.112
1.506HisLys: 1.506 ± 0.067
2.347HisLeu: 2.347 ± 0.103
0.627HisMet: 0.627 ± 0.047
1.492HisAsn: 1.492 ± 0.073
1.258HisPro: 1.258 ± 0.068
0.965HisGln: 0.965 ± 0.063
1.175HisArg: 1.175 ± 0.073
1.41HisSer: 1.41 ± 0.064
1.12HisThr: 1.12 ± 0.055
1.289HisVal: 1.289 ± 0.067
0.327HisTrp: 0.327 ± 0.034
1.058HisTyr: 1.058 ± 0.052
0.0HisXaa: 0.0 ± 0.0
Ile
7.021IleAla: 7.021 ± 0.155
1.32IleCys: 1.32 ± 0.07
5.505IleAsp: 5.505 ± 0.144
5.846IleGlu: 5.846 ± 0.15
4.181IlePhe: 4.181 ± 0.134
6.904IleGly: 6.904 ± 0.162
2.358IleHis: 2.358 ± 0.092
10.316IleIle: 10.316 ± 0.256
7.031IleLys: 7.031 ± 0.155
9.806IleLeu: 9.806 ± 0.208
2.213IleMet: 2.213 ± 0.085
7.528IleAsn: 7.528 ± 0.197
4.105IlePro: 4.105 ± 0.112
3.457IleGln: 3.457 ± 0.118
4.402IleArg: 4.402 ± 0.114
7.207IleSer: 7.207 ± 0.142
5.742IleThr: 5.742 ± 0.157
5.229IleVal: 5.229 ± 0.149
1.024IleTrp: 1.024 ± 0.059
3.288IleTyr: 3.288 ± 0.11
0.0IleXaa: 0.0 ± 0.0
Lys
3.688LysAla: 3.688 ± 0.12
0.569LysCys: 0.569 ± 0.045
2.902LysAsp: 2.902 ± 0.098
4.122LysGlu: 4.122 ± 0.12
2.192LysPhe: 2.192 ± 0.095
3.526LysGly: 3.526 ± 0.097
1.486LysHis: 1.486 ± 0.069
7.421LysIle: 7.421 ± 0.166
5.911LysLys: 5.911 ± 0.164
6.973LysLeu: 6.973 ± 0.162
1.847LysMet: 1.847 ± 0.083
5.405LysAsn: 5.405 ± 0.129
2.137LysPro: 2.137 ± 0.083
2.816LysGln: 2.816 ± 0.085
3.226LysArg: 3.226 ± 0.117
3.74LysSer: 3.74 ± 0.108
2.909LysThr: 2.909 ± 0.109
3.871LysVal: 3.871 ± 0.114
0.686LysTrp: 0.686 ± 0.045
2.578LysTyr: 2.578 ± 0.108
0.0LysXaa: 0.0 ± 0.0
Leu
7.049LeuAla: 7.049 ± 0.164
1.31LeuCys: 1.31 ± 0.072
4.722LeuAsp: 4.722 ± 0.12
5.632LeuGlu: 5.632 ± 0.142
4.412LeuPhe: 4.412 ± 0.135
5.863LeuGly: 5.863 ± 0.139
2.695LeuHis: 2.695 ± 0.118
10.14LeuIle: 10.14 ± 0.214
6.997LeuLys: 6.997 ± 0.148
11.106LeuLeu: 11.106 ± 0.252
2.561LeuMet: 2.561 ± 0.105
6.342LeuAsn: 6.342 ± 0.165
4.619LeuPro: 4.619 ± 0.113
3.964LeuGln: 3.964 ± 0.105
5.256LeuArg: 5.256 ± 0.141
6.828LeuSer: 6.828 ± 0.185
5.36LeuThr: 5.36 ± 0.151
5.553LeuVal: 5.553 ± 0.14
1.0LeuTrp: 1.0 ± 0.054
3.371LeuTyr: 3.371 ± 0.114
0.0LeuXaa: 0.0 ± 0.0
Met
1.761MetAla: 1.761 ± 0.079
0.255MetCys: 0.255 ± 0.028
0.91MetAsp: 0.91 ± 0.057
1.155MetGlu: 1.155 ± 0.068
0.893MetPhe: 0.893 ± 0.054
1.465MetGly: 1.465 ± 0.068
0.62MetHis: 0.62 ± 0.05
2.575MetIle: 2.575 ± 0.096
1.568MetLys: 1.568 ± 0.066
2.995MetLeu: 2.995 ± 0.111
0.7MetMet: 0.7 ± 0.043
1.475MetAsn: 1.475 ± 0.074
1.017MetPro: 1.017 ± 0.072
1.12MetGln: 1.12 ± 0.065
1.227MetArg: 1.227 ± 0.062
1.623MetSer: 1.623 ± 0.077
1.234MetThr: 1.234 ± 0.059
1.458MetVal: 1.458 ± 0.076
0.186MetTrp: 0.186 ± 0.024
0.645MetTyr: 0.645 ± 0.046
0.0MetXaa: 0.0 ± 0.0
Asn
3.171AsnAla: 3.171 ± 0.105
0.731AsnCys: 0.731 ± 0.05
2.585AsnAsp: 2.585 ± 0.095
3.126AsnGlu: 3.126 ± 0.116
2.788AsnPhe: 2.788 ± 0.098
3.43AsnGly: 3.43 ± 0.116
1.486AsnHis: 1.486 ± 0.066
7.335AsnIle: 7.335 ± 0.164
5.122AsnLys: 5.122 ± 0.155
5.946AsnLeu: 5.946 ± 0.168
1.506AsnMet: 1.506 ± 0.075
4.884AsnAsn: 4.884 ± 0.164
2.358AsnPro: 2.358 ± 0.087
2.433AsnGln: 2.433 ± 0.09
2.826AsnArg: 2.826 ± 0.099
3.678AsnSer: 3.678 ± 0.111
3.071AsnThr: 3.071 ± 0.109
3.14AsnVal: 3.14 ± 0.101
0.827AsnTrp: 0.827 ± 0.064
2.402AsnTyr: 2.402 ± 0.092
0.0AsnXaa: 0.0 ± 0.0
Pro
1.665ProAla: 1.665 ± 0.072
0.427ProCys: 0.427 ± 0.038
1.561ProAsp: 1.561 ± 0.074
2.185ProGlu: 2.185 ± 0.092
1.554ProPhe: 1.554 ± 0.077
2.316ProGly: 2.316 ± 0.093
0.982ProHis: 0.982 ± 0.056
3.867ProIle: 3.867 ± 0.119
2.082ProLys: 2.082 ± 0.088
3.836ProLeu: 3.836 ± 0.113
0.889ProMet: 0.889 ± 0.059
2.109ProAsn: 2.109 ± 0.09
0.962ProPro: 0.962 ± 0.056
1.32ProGln: 1.32 ± 0.07
1.351ProArg: 1.351 ± 0.071
2.292ProSer: 2.292 ± 0.091
2.023ProThr: 2.023 ± 0.076
2.296ProVal: 2.296 ± 0.095
0.479ProTrp: 0.479 ± 0.046
1.417ProTyr: 1.417 ± 0.061
0.0ProXaa: 0.0 ± 0.0
Gln
2.561GlnAla: 2.561 ± 0.094
0.403GlnCys: 0.403 ± 0.034
1.513GlnAsp: 1.513 ± 0.071
2.14GlnGlu: 2.14 ± 0.094
1.389GlnPhe: 1.389 ± 0.074
2.075GlnGly: 2.075 ± 0.092
1.027GlnHis: 1.027 ± 0.056
3.547GlnIle: 3.547 ± 0.105
2.792GlnLys: 2.792 ± 0.099
4.46GlnLeu: 4.46 ± 0.136
0.827GlnMet: 0.827 ± 0.05
2.127GlnAsn: 2.127 ± 0.092
1.289GlnPro: 1.289 ± 0.079
2.003GlnGln: 2.003 ± 0.087
2.099GlnArg: 2.099 ± 0.089
2.206GlnSer: 2.206 ± 0.103
1.527GlnThr: 1.527 ± 0.065
2.444GlnVal: 2.444 ± 0.106
0.458GlnTrp: 0.458 ± 0.039
1.461GlnTyr: 1.461 ± 0.066
0.0GlnXaa: 0.0 ± 0.0
Arg
2.93ArgAla: 2.93 ± 0.105
0.548ArgCys: 0.548 ± 0.042
2.202ArgAsp: 2.202 ± 0.083
2.902ArgGlu: 2.902 ± 0.126
2.382ArgPhe: 2.382 ± 0.095
2.644ArgGly: 2.644 ± 0.102
1.093ArgHis: 1.093 ± 0.056
4.801ArgIle: 4.801 ± 0.134
2.933ArgLys: 2.933 ± 0.097
5.143ArgLeu: 5.143 ± 0.141
1.117ArgMet: 1.117 ± 0.059
2.754ArgAsn: 2.754 ± 0.102
1.537ArgPro: 1.537 ± 0.084
1.985ArgGln: 1.985 ± 0.096
2.709ArgArg: 2.709 ± 0.115
2.685ArgSer: 2.685 ± 0.1
2.247ArgThr: 2.247 ± 0.104
2.657ArgVal: 2.657 ± 0.11
0.617ArgTrp: 0.617 ± 0.042
1.951ArgTyr: 1.951 ± 0.086
0.0ArgXaa: 0.0 ± 0.0
Ser
3.526SerAla: 3.526 ± 0.113
0.782SerCys: 0.782 ± 0.046
2.561SerAsp: 2.561 ± 0.09
2.857SerGlu: 2.857 ± 0.107
2.819SerPhe: 2.819 ± 0.101
4.388SerGly: 4.388 ± 0.132
1.582SerHis: 1.582 ± 0.073
6.563SerIle: 6.563 ± 0.16
3.953SerLys: 3.953 ± 0.13
6.938SerLeu: 6.938 ± 0.157
1.523SerMet: 1.523 ± 0.065
3.822SerAsn: 3.822 ± 0.133
1.961SerPro: 1.961 ± 0.071
2.22SerGln: 2.22 ± 0.091
2.937SerArg: 2.937 ± 0.099
4.174SerSer: 4.174 ± 0.13
3.247SerThr: 3.247 ± 0.099
3.233SerVal: 3.233 ± 0.112
0.793SerTrp: 0.793 ± 0.057
2.285SerTyr: 2.285 ± 0.095
0.0SerXaa: 0.0 ± 0.0
Thr
3.061ThrAla: 3.061 ± 0.11
0.638ThrCys: 0.638 ± 0.051
2.061ThrAsp: 2.061 ± 0.086
2.175ThrGlu: 2.175 ± 0.085
2.068ThrPhe: 2.068 ± 0.071
3.502ThrGly: 3.502 ± 0.118
1.206ThrHis: 1.206 ± 0.06
4.87ThrIle: 4.87 ± 0.148
2.978ThrLys: 2.978 ± 0.091
5.849ThrLeu: 5.849 ± 0.171
1.072ThrMet: 1.072 ± 0.062
2.819ThrAsn: 2.819 ± 0.11
2.161ThrPro: 2.161 ± 0.079
1.81ThrGln: 1.81 ± 0.078
2.244ThrArg: 2.244 ± 0.102
3.143ThrSer: 3.143 ± 0.106
2.85ThrThr: 2.85 ± 0.107
2.968ThrVal: 2.968 ± 0.104
0.596ThrTrp: 0.596 ± 0.043
1.465ThrTyr: 1.465 ± 0.068
0.0ThrXaa: 0.0 ± 0.0
Val
3.588ValAla: 3.588 ± 0.143
0.717ValCys: 0.717 ± 0.051
2.723ValAsp: 2.723 ± 0.115
3.012ValGlu: 3.012 ± 0.12
2.189ValPhe: 2.189 ± 0.085
3.602ValGly: 3.602 ± 0.117
1.22ValHis: 1.22 ± 0.064
5.749ValIle: 5.749 ± 0.141
3.664ValLys: 3.664 ± 0.129
5.635ValLeu: 5.635 ± 0.143
1.455ValMet: 1.455 ± 0.08
3.237ValAsn: 3.237 ± 0.112
2.034ValPro: 2.034 ± 0.091
1.83ValGln: 1.83 ± 0.09
2.747ValArg: 2.747 ± 0.109
3.423ValSer: 3.423 ± 0.105
2.947ValThr: 2.947 ± 0.101
3.34ValVal: 3.34 ± 0.126
0.486ValTrp: 0.486 ± 0.041
1.73ValTyr: 1.73 ± 0.088
0.0ValXaa: 0.0 ± 0.0
Trp
0.517TrpAla: 0.517 ± 0.043
0.179TrpCys: 0.179 ± 0.026
0.417TrpAsp: 0.417 ± 0.045
0.51TrpGlu: 0.51 ± 0.044
0.61TrpPhe: 0.61 ± 0.047
0.586TrpGly: 0.586 ± 0.043
0.358TrpHis: 0.358 ± 0.035
1.199TrpIle: 1.199 ± 0.062
0.769TrpLys: 0.769 ± 0.053
1.492TrpLeu: 1.492 ± 0.092
0.334TrpMet: 0.334 ± 0.032
0.713TrpAsn: 0.713 ± 0.055
0.427TrpPro: 0.427 ± 0.035
0.658TrpGln: 0.658 ± 0.044
0.682TrpArg: 0.682 ± 0.053
0.648TrpSer: 0.648 ± 0.053
0.331TrpThr: 0.331 ± 0.035
0.465TrpVal: 0.465 ± 0.037
0.138TrpTrp: 0.138 ± 0.023
0.441TrpTyr: 0.441 ± 0.039
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.944TyrAla: 1.944 ± 0.078
0.583TyrCys: 0.583 ± 0.046
1.796TyrAsp: 1.796 ± 0.077
1.579TyrGlu: 1.579 ± 0.069
1.596TyrPhe: 1.596 ± 0.085
2.282TyrGly: 2.282 ± 0.09
1.113TyrHis: 1.113 ± 0.065
3.164TyrIle: 3.164 ± 0.102
2.161TyrLys: 2.161 ± 0.08
3.771TyrLeu: 3.771 ± 0.125
0.789TyrMet: 0.789 ± 0.055
2.451TyrAsn: 2.451 ± 0.102
1.306TyrPro: 1.306 ± 0.059
1.661TyrGln: 1.661 ± 0.079
1.679TyrArg: 1.679 ± 0.071
2.406TyrSer: 2.406 ± 0.088
1.637TyrThr: 1.637 ± 0.069
1.623TyrVal: 1.623 ± 0.07
0.538TyrTrp: 0.538 ± 0.047
1.427TyrTyr: 1.427 ± 0.074
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 881 proteins (290127 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski