Amino acid dipepetide frequency for Flammeovirga sp. SJP92

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.93AlaAla: 2.93 ± 0.049
0.473AlaCys: 0.473 ± 0.015
3.202AlaAsp: 3.202 ± 0.04
3.863AlaGlu: 3.863 ± 0.049
3.085AlaPhe: 3.085 ± 0.041
3.823AlaGly: 3.823 ± 0.048
1.04AlaHis: 1.04 ± 0.023
4.365AlaIle: 4.365 ± 0.054
4.0AlaLys: 4.0 ± 0.048
5.638AlaLeu: 5.638 ± 0.055
1.431AlaMet: 1.431 ± 0.023
2.952AlaAsn: 2.952 ± 0.037
1.974AlaPro: 1.974 ± 0.036
2.481AlaGln: 2.481 ± 0.037
1.718AlaArg: 1.718 ± 0.03
4.311AlaSer: 4.311 ± 0.051
3.425AlaThr: 3.425 ± 0.048
3.714AlaVal: 3.714 ± 0.039
0.62AlaTrp: 0.62 ± 0.016
2.512AlaTyr: 2.512 ± 0.037
0.0AlaXaa: 0.0 ± 0.0
Cys
0.395CysAla: 0.395 ± 0.016
0.09CysCys: 0.09 ± 0.007
0.431CysAsp: 0.431 ± 0.016
0.466CysGlu: 0.466 ± 0.017
0.414CysPhe: 0.414 ± 0.014
0.529CysGly: 0.529 ± 0.015
0.199CysHis: 0.199 ± 0.009
0.55CysIle: 0.55 ± 0.017
0.437CysLys: 0.437 ± 0.014
0.62CysLeu: 0.62 ± 0.018
0.14CysMet: 0.14 ± 0.007
0.401CysAsn: 0.401 ± 0.014
0.25CysPro: 0.25 ± 0.012
0.249CysGln: 0.249 ± 0.012
0.212CysArg: 0.212 ± 0.009
0.576CysSer: 0.576 ± 0.017
0.434CysThr: 0.434 ± 0.016
0.414CysVal: 0.414 ± 0.015
0.081CysTrp: 0.081 ± 0.006
0.294CysTyr: 0.294 ± 0.01
0.0CysXaa: 0.0 ± 0.0
Asp
3.524AspAla: 3.524 ± 0.045
0.426AspCys: 0.426 ± 0.015
3.093AspAsp: 3.093 ± 0.041
4.068AspGlu: 4.068 ± 0.047
3.546AspPhe: 3.546 ± 0.037
4.069AspGly: 4.069 ± 0.065
1.236AspHis: 1.236 ± 0.023
4.466AspIle: 4.466 ± 0.045
3.979AspLys: 3.979 ± 0.051
5.594AspLeu: 5.594 ± 0.049
1.184AspMet: 1.184 ± 0.022
3.214AspAsn: 3.214 ± 0.045
2.086AspPro: 2.086 ± 0.036
2.426AspGln: 2.426 ± 0.036
2.003AspArg: 2.003 ± 0.031
3.067AspSer: 3.067 ± 0.05
2.75AspThr: 2.75 ± 0.043
3.653AspVal: 3.653 ± 0.038
0.938AspTrp: 0.938 ± 0.026
2.934AspTyr: 2.934 ± 0.039
0.0AspXaa: 0.0 ± 0.0
Glu
4.4GluAla: 4.4 ± 0.044
0.382GluCys: 0.382 ± 0.015
4.115GluAsp: 4.115 ± 0.044
6.284GluGlu: 6.284 ± 0.071
2.929GluPhe: 2.929 ± 0.035
4.941GluGly: 4.941 ± 0.066
1.301GluHis: 1.301 ± 0.025
5.576GluIle: 5.576 ± 0.047
6.239GluLys: 6.239 ± 0.066
6.509GluLeu: 6.509 ± 0.062
1.77GluMet: 1.77 ± 0.03
4.691GluAsn: 4.691 ± 0.049
1.413GluPro: 1.413 ± 0.027
2.546GluGln: 2.546 ± 0.033
2.579GluArg: 2.579 ± 0.039
3.614GluSer: 3.614 ± 0.041
3.402GluThr: 3.402 ± 0.037
5.117GluVal: 5.117 ± 0.053
0.888GluTrp: 0.888 ± 0.02
2.955GluTyr: 2.955 ± 0.035
0.0GluXaa: 0.0 ± 0.0
Phe
2.637PheAla: 2.637 ± 0.033
0.423PheCys: 0.423 ± 0.014
3.49PheAsp: 3.49 ± 0.049
3.639PheGlu: 3.639 ± 0.046
2.758PhePhe: 2.758 ± 0.043
3.369PheGly: 3.369 ± 0.036
0.958PheHis: 0.958 ± 0.021
3.773PheIle: 3.773 ± 0.048
3.51PheLys: 3.51 ± 0.039
4.328PheLeu: 4.328 ± 0.052
1.165PheMet: 1.165 ± 0.023
3.127PheAsn: 3.127 ± 0.042
1.626PhePro: 1.626 ± 0.025
1.767PheGln: 1.767 ± 0.027
1.663PheArg: 1.663 ± 0.032
3.987PheSer: 3.987 ± 0.049
3.229PheThr: 3.229 ± 0.048
2.862PheVal: 2.862 ± 0.04
0.556PheTrp: 0.556 ± 0.016
2.357PheTyr: 2.357 ± 0.032
0.0PheXaa: 0.0 ± 0.0
Gly
3.999GlyAla: 3.999 ± 0.056
0.568GlyCys: 0.568 ± 0.022
3.808GlyAsp: 3.808 ± 0.055
4.361GlyGlu: 4.361 ± 0.05
3.374GlyPhe: 3.374 ± 0.044
4.606GlyGly: 4.606 ± 0.076
1.177GlyHis: 1.177 ± 0.024
5.081GlyIle: 5.081 ± 0.048
4.985GlyLys: 4.985 ± 0.063
5.452GlyLeu: 5.452 ± 0.055
1.661GlyMet: 1.661 ± 0.027
3.746GlyAsn: 3.746 ± 0.051
1.329GlyPro: 1.329 ± 0.028
2.225GlyGln: 2.225 ± 0.035
2.149GlyArg: 2.149 ± 0.033
3.951GlySer: 3.951 ± 0.06
3.955GlyThr: 3.955 ± 0.061
4.664GlyVal: 4.664 ± 0.05
0.877GlyTrp: 0.877 ± 0.023
3.04GlyTyr: 3.04 ± 0.042
0.0GlyXaa: 0.0 ± 0.0
His
0.889HisAla: 0.889 ± 0.021
0.164HisCys: 0.164 ± 0.009
0.951HisAsp: 0.951 ± 0.021
1.139HisGlu: 1.139 ± 0.024
1.251HisPhe: 1.251 ± 0.023
1.128HisGly: 1.128 ± 0.024
0.58HisHis: 0.58 ± 0.018
1.39HisIle: 1.39 ± 0.027
1.243HisLys: 1.243 ± 0.027
1.982HisLeu: 1.982 ± 0.032
0.368HisMet: 0.368 ± 0.013
0.997HisAsn: 0.997 ± 0.022
0.902HisPro: 0.902 ± 0.02
0.958HisGln: 0.958 ± 0.021
0.711HisArg: 0.711 ± 0.017
1.222HisSer: 1.222 ± 0.025
1.004HisThr: 1.004 ± 0.024
0.947HisVal: 0.947 ± 0.019
0.276HisTrp: 0.276 ± 0.011
0.984HisTyr: 0.984 ± 0.021
0.0HisXaa: 0.0 ± 0.0
Ile
4.629IleAla: 4.629 ± 0.05
0.583IleCys: 0.583 ± 0.019
5.006IleAsp: 5.006 ± 0.047
5.672IleGlu: 5.672 ± 0.054
3.31IlePhe: 3.31 ± 0.044
4.864IleGly: 4.864 ± 0.054
1.463IleHis: 1.463 ± 0.028
5.273IleIle: 5.273 ± 0.058
5.315IleLys: 5.315 ± 0.057
6.247IleLeu: 6.247 ± 0.057
1.326IleMet: 1.326 ± 0.025
4.646IleAsn: 4.646 ± 0.051
2.974IlePro: 2.974 ± 0.037
2.807IleGln: 2.807 ± 0.038
2.492IleArg: 2.492 ± 0.037
5.597IleSer: 5.597 ± 0.051
4.71IleThr: 4.71 ± 0.062
4.295IleVal: 4.295 ± 0.044
0.735IleTrp: 0.735 ± 0.017
2.962IleTyr: 2.962 ± 0.04
0.0IleXaa: 0.0 ± 0.0
Lys
4.51LysAla: 4.51 ± 0.055
0.361LysCys: 0.361 ± 0.014
4.375LysAsp: 4.375 ± 0.051
6.722LysGlu: 6.722 ± 0.076
2.784LysPhe: 2.784 ± 0.037
5.016LysGly: 5.016 ± 0.064
1.312LysHis: 1.312 ± 0.025
5.448LysIle: 5.448 ± 0.059
6.682LysLys: 6.682 ± 0.078
6.056LysLeu: 6.056 ± 0.061
1.979LysMet: 1.979 ± 0.029
4.564LysAsn: 4.564 ± 0.048
2.096LysPro: 2.096 ± 0.033
2.387LysGln: 2.387 ± 0.035
2.685LysArg: 2.685 ± 0.041
4.504LysSer: 4.504 ± 0.053
3.928LysThr: 3.928 ± 0.043
5.502LysVal: 5.502 ± 0.056
0.934LysTrp: 0.934 ± 0.022
3.291LysTyr: 3.291 ± 0.048
0.0LysXaa: 0.0 ± 0.0
Leu
4.767LeuAla: 4.767 ± 0.056
0.659LeuCys: 0.659 ± 0.017
5.051LeuAsp: 5.051 ± 0.046
6.508LeuGlu: 6.508 ± 0.063
4.725LeuPhe: 4.725 ± 0.056
5.52LeuGly: 5.52 ± 0.054
1.632LeuHis: 1.632 ± 0.031
6.456LeuIle: 6.456 ± 0.071
7.28LeuLys: 7.28 ± 0.078
8.408LeuLeu: 8.408 ± 0.073
2.177LeuMet: 2.177 ± 0.036
5.309LeuAsn: 5.309 ± 0.052
3.553LeuPro: 3.553 ± 0.047
3.303LeuGln: 3.303 ± 0.039
3.072LeuArg: 3.072 ± 0.034
7.149LeuSer: 7.149 ± 0.066
5.096LeuThr: 5.096 ± 0.053
4.789LeuVal: 4.789 ± 0.049
0.955LeuTrp: 0.955 ± 0.021
3.461LeuTyr: 3.461 ± 0.036
0.0LeuXaa: 0.0 ± 0.0
Met
1.417MetAla: 1.417 ± 0.025
0.146MetCys: 0.146 ± 0.009
1.292MetAsp: 1.292 ± 0.027
1.49MetGlu: 1.49 ± 0.027
0.876MetPhe: 0.876 ± 0.017
1.514MetGly: 1.514 ± 0.033
0.437MetHis: 0.437 ± 0.013
1.64MetIle: 1.64 ± 0.029
2.275MetLys: 2.275 ± 0.033
1.937MetLeu: 1.937 ± 0.031
0.687MetMet: 0.687 ± 0.02
1.433MetAsn: 1.433 ± 0.023
0.842MetPro: 0.842 ± 0.021
0.758MetGln: 0.758 ± 0.018
0.834MetArg: 0.834 ± 0.022
1.536MetSer: 1.536 ± 0.028
1.299MetThr: 1.299 ± 0.026
1.317MetVal: 1.317 ± 0.026
0.211MetTrp: 0.211 ± 0.009
0.785MetTyr: 0.785 ± 0.02
0.0MetXaa: 0.0 ± 0.0
Asn
3.601AsnAla: 3.601 ± 0.041
0.413AsnCys: 0.413 ± 0.013
3.353AsnAsp: 3.353 ± 0.042
3.971AsnGlu: 3.971 ± 0.045
2.843AsnPhe: 2.843 ± 0.041
4.24AsnGly: 4.24 ± 0.063
1.198AsnHis: 1.198 ± 0.024
4.572AsnIle: 4.572 ± 0.048
4.013AsnLys: 4.013 ± 0.047
4.971AsnLeu: 4.971 ± 0.056
1.205AsnMet: 1.205 ± 0.022
3.814AsnAsn: 3.814 ± 0.053
2.445AsnPro: 2.445 ± 0.04
2.297AsnGln: 2.297 ± 0.034
2.014AsnArg: 2.014 ± 0.035
3.82AsnSer: 3.82 ± 0.047
3.666AsnThr: 3.666 ± 0.049
3.608AsnVal: 3.608 ± 0.047
0.809AsnTrp: 0.809 ± 0.021
2.917AsnTyr: 2.917 ± 0.04
0.0AsnXaa: 0.0 ± 0.0
Pro
1.797ProAla: 1.797 ± 0.031
0.187ProCys: 0.187 ± 0.01
1.911ProAsp: 1.911 ± 0.029
2.629ProGlu: 2.629 ± 0.039
1.916ProPhe: 1.916 ± 0.025
1.616ProGly: 1.616 ± 0.03
0.691ProHis: 0.691 ± 0.018
2.501ProIle: 2.501 ± 0.033
2.29ProLys: 2.29 ± 0.031
3.026ProLeu: 3.026 ± 0.041
0.731ProMet: 0.731 ± 0.016
2.172ProAsn: 2.172 ± 0.032
0.867ProPro: 0.867 ± 0.021
1.256ProGln: 1.256 ± 0.023
0.913ProArg: 0.913 ± 0.022
2.7ProSer: 2.7 ± 0.039
2.068ProThr: 2.068 ± 0.036
2.184ProVal: 2.184 ± 0.031
0.373ProTrp: 0.373 ± 0.014
1.488ProTyr: 1.488 ± 0.028
0.0ProXaa: 0.0 ± 0.0
Gln
1.883GlnAla: 1.883 ± 0.03
0.199GlnCys: 0.199 ± 0.009
1.83GlnAsp: 1.83 ± 0.028
2.722GlnGlu: 2.722 ± 0.037
1.923GlnPhe: 1.923 ± 0.025
2.056GlnGly: 2.056 ± 0.035
0.72GlnHis: 0.72 ± 0.015
2.526GlnIle: 2.526 ± 0.033
3.253GlnLys: 3.253 ± 0.048
3.761GlnLeu: 3.761 ± 0.044
0.897GlnMet: 0.897 ± 0.019
2.324GlnAsn: 2.324 ± 0.034
1.138GlnPro: 1.138 ± 0.024
1.595GlnGln: 1.595 ± 0.036
1.309GlnArg: 1.309 ± 0.026
2.283GlnSer: 2.283 ± 0.03
1.879GlnThr: 1.879 ± 0.03
2.109GlnVal: 2.109 ± 0.029
0.508GlnTrp: 0.508 ± 0.017
1.587GlnTyr: 1.587 ± 0.029
0.0GlnXaa: 0.0 ± 0.0
Arg
1.873ArgAla: 1.873 ± 0.031
0.202ArgCys: 0.202 ± 0.01
1.783ArgAsp: 1.783 ± 0.028
2.22ArgGlu: 2.22 ± 0.035
1.819ArgPhe: 1.819 ± 0.03
2.002ArgGly: 2.002 ± 0.034
0.589ArgHis: 0.589 ± 0.015
2.682ArgIle: 2.682 ± 0.031
2.752ArgLys: 2.752 ± 0.044
3.136ArgLeu: 3.136 ± 0.039
0.897ArgMet: 0.897 ± 0.021
2.056ArgAsn: 2.056 ± 0.031
1.103ArgPro: 1.103 ± 0.024
1.084ArgGln: 1.084 ± 0.024
1.312ArgArg: 1.312 ± 0.03
1.954ArgSer: 1.954 ± 0.029
1.798ArgThr: 1.798 ± 0.026
2.182ArgVal: 2.182 ± 0.033
0.457ArgTrp: 0.457 ± 0.013
1.603ArgTyr: 1.603 ± 0.027
0.0ArgXaa: 0.0 ± 0.0
Ser
3.661SerAla: 3.661 ± 0.041
0.625SerCys: 0.625 ± 0.021
3.966SerAsp: 3.966 ± 0.053
4.297SerGlu: 4.297 ± 0.042
4.123SerPhe: 4.123 ± 0.053
4.367SerGly: 4.367 ± 0.057
1.207SerHis: 1.207 ± 0.022
5.737SerIle: 5.737 ± 0.058
4.809SerLys: 4.809 ± 0.052
6.237SerLeu: 6.237 ± 0.051
1.403SerMet: 1.403 ± 0.025
4.111SerAsn: 4.111 ± 0.054
2.185SerPro: 2.185 ± 0.03
2.228SerGln: 2.228 ± 0.029
2.087SerArg: 2.087 ± 0.036
5.083SerSer: 5.083 ± 0.067
4.062SerThr: 4.062 ± 0.049
4.033SerVal: 4.033 ± 0.046
0.775SerTrp: 0.775 ± 0.018
3.005SerTyr: 3.005 ± 0.038
0.0SerXaa: 0.0 ± 0.0
Thr
3.547ThrAla: 3.547 ± 0.05
0.34ThrCys: 0.34 ± 0.015
3.308ThrAsp: 3.308 ± 0.047
3.475ThrGlu: 3.475 ± 0.046
3.362ThrPhe: 3.362 ± 0.05
3.7ThrGly: 3.7 ± 0.051
1.0ThrHis: 1.0 ± 0.021
4.498ThrIle: 4.498 ± 0.063
3.53ThrLys: 3.53 ± 0.041
5.701ThrLeu: 5.701 ± 0.064
1.026ThrMet: 1.026 ± 0.024
3.043ThrAsn: 3.043 ± 0.046
2.526ThrPro: 2.526 ± 0.04
1.861ThrGln: 1.861 ± 0.028
1.555ThrArg: 1.555 ± 0.026
4.194ThrSer: 4.194 ± 0.058
3.486ThrThr: 3.486 ± 0.062
3.895ThrVal: 3.895 ± 0.06
0.695ThrTrp: 0.695 ± 0.019
2.605ThrTyr: 2.605 ± 0.042
0.0ThrXaa: 0.0 ± 0.0
Val
3.903ValAla: 3.903 ± 0.053
0.499ValCys: 0.499 ± 0.014
3.879ValAsp: 3.879 ± 0.04
4.497ValGlu: 4.497 ± 0.05
3.095ValPhe: 3.095 ± 0.036
4.023ValGly: 4.023 ± 0.047
1.05ValHis: 1.05 ± 0.023
4.639ValIle: 4.639 ± 0.046
4.53ValLys: 4.53 ± 0.048
5.43ValLeu: 5.43 ± 0.049
1.508ValMet: 1.508 ± 0.026
3.644ValAsn: 3.644 ± 0.041
2.13ValPro: 2.13 ± 0.032
1.956ValGln: 1.956 ± 0.027
2.095ValArg: 2.095 ± 0.036
4.472ValSer: 4.472 ± 0.046
3.775ValThr: 3.775 ± 0.063
4.172ValVal: 4.172 ± 0.049
0.676ValTrp: 0.676 ± 0.019
2.648ValTyr: 2.648 ± 0.033
0.0ValXaa: 0.0 ± 0.0
Trp
0.671TrpAla: 0.671 ± 0.018
0.09TrpCys: 0.09 ± 0.006
0.703TrpAsp: 0.703 ± 0.02
0.903TrpGlu: 0.903 ± 0.022
0.522TrpPhe: 0.522 ± 0.014
0.862TrpGly: 0.862 ± 0.02
0.277TrpHis: 0.277 ± 0.012
0.779TrpIle: 0.779 ± 0.019
0.939TrpLys: 0.939 ± 0.024
0.966TrpLeu: 0.966 ± 0.021
0.363TrpMet: 0.363 ± 0.011
0.813TrpAsn: 0.813 ± 0.021
0.266TrpPro: 0.266 ± 0.012
0.415TrpGln: 0.415 ± 0.014
0.449TrpArg: 0.449 ± 0.014
0.859TrpSer: 0.859 ± 0.024
0.696TrpThr: 0.696 ± 0.024
0.828TrpVal: 0.828 ± 0.018
0.183TrpTrp: 0.183 ± 0.01
0.543TrpTyr: 0.543 ± 0.022
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.521TyrAla: 2.521 ± 0.034
0.351TyrCys: 0.351 ± 0.015
2.708TyrAsp: 2.708 ± 0.037
2.724TyrGlu: 2.724 ± 0.042
2.568TyrPhe: 2.568 ± 0.035
2.764TyrGly: 2.764 ± 0.036
1.019TyrHis: 1.019 ± 0.02
2.954TyrIle: 2.954 ± 0.032
3.076TyrLys: 3.076 ± 0.045
3.874TyrLeu: 3.874 ± 0.046
0.807TyrMet: 0.807 ± 0.018
2.711TyrAsn: 2.711 ± 0.041
1.613TyrPro: 1.613 ± 0.028
1.905TyrGln: 1.905 ± 0.032
1.652TyrArg: 1.652 ± 0.029
3.124TyrSer: 3.124 ± 0.045
2.688TyrThr: 2.688 ± 0.049
2.335TyrVal: 2.335 ± 0.031
0.579TyrTrp: 0.579 ± 0.018
2.246TyrTyr: 2.246 ± 0.04
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 6269 proteins (2376931 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski