Amino acid dipepetide frequency for Arhar cryptic virus-I

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.146AlaAla: 5.146 ± 1.331
0.0AlaCys: 0.0 ± 0.0
6.003AlaAsp: 6.003 ± 2.034
7.719AlaGlu: 7.719 ± 2.024
5.146AlaPhe: 5.146 ± 2.309
6.003AlaGly: 6.003 ± 0.152
0.858AlaHis: 0.858 ± 0.719
6.003AlaIle: 6.003 ± 0.98
1.715AlaLys: 1.715 ± 1.753
12.007AlaLeu: 12.007 ± 2.717
0.0AlaMet: 0.0 ± 0.0
0.858AlaAsn: 0.858 ± 0.61
2.573AlaPro: 2.573 ± 0.23
2.573AlaGln: 2.573 ± 1.329
5.146AlaArg: 5.146 ± 0.803
6.861AlaSer: 6.861 ± 1.657
4.288AlaThr: 4.288 ± 1.914
4.288AlaVal: 4.288 ± 2.265
2.573AlaTrp: 2.573 ± 0.23
0.858AlaTyr: 0.858 ± 0.719
0.0AlaXaa: 0.0 ± 0.0
Cys
0.858CysAla: 0.858 ± 0.61
0.0CysCys: 0.0 ± 0.0
0.0CysAsp: 0.0 ± 0.0
0.858CysGlu: 0.858 ± 0.719
0.858CysPhe: 0.858 ± 0.61
0.0CysGly: 0.0 ± 0.0
0.0CysHis: 0.0 ± 0.0
0.0CysIle: 0.0 ± 0.0
0.0CysLys: 0.0 ± 0.0
2.573CysLeu: 2.573 ± 0.23
0.858CysMet: 0.858 ± 0.877
0.858CysAsn: 0.858 ± 0.719
0.858CysPro: 0.858 ± 0.719
0.858CysGln: 0.858 ± 0.61
0.0CysArg: 0.0 ± 0.0
0.0CysSer: 0.0 ± 0.0
0.858CysThr: 0.858 ± 0.877
0.0CysVal: 0.0 ± 0.0
0.0CysTrp: 0.0 ± 0.0
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
2.573AspAla: 2.573 ± 0.94
0.0AspCys: 0.0 ± 0.0
0.858AspAsp: 0.858 ± 0.61
5.146AspGlu: 5.146 ± 2.229
0.858AspPhe: 0.858 ± 0.877
0.858AspGly: 0.858 ± 0.719
0.858AspHis: 0.858 ± 0.61
4.288AspIle: 4.288 ± 0.664
3.431AspLys: 3.431 ± 1.434
3.431AspLeu: 3.431 ± 2.386
1.715AspMet: 1.715 ± 0.84
0.0AspAsn: 0.0 ± 0.0
4.288AspPro: 4.288 ± 2.265
2.573AspGln: 2.573 ± 1.295
2.573AspArg: 2.573 ± 0.23
4.288AspSer: 4.288 ± 1.994
1.715AspThr: 1.715 ± 0.84
5.146AspVal: 5.146 ± 1.331
0.858AspTrp: 0.858 ± 0.61
2.573AspTyr: 2.573 ± 1.154
0.0AspXaa: 0.0 ± 0.0
Glu
7.719GluAla: 7.719 ± 2.129
0.0GluCys: 0.0 ± 0.0
4.288GluAsp: 4.288 ± 1.069
1.715GluGlu: 1.715 ± 0.673
1.715GluPhe: 1.715 ± 0.673
6.003GluGly: 6.003 ± 1.232
0.0GluHis: 0.0 ± 0.0
5.146GluIle: 5.146 ± 2.878
0.858GluLys: 0.858 ± 0.719
7.719GluLeu: 7.719 ± 0.81
1.715GluMet: 1.715 ± 0.743
2.573GluAsn: 2.573 ± 0.23
1.715GluPro: 1.715 ± 0.84
3.431GluGln: 3.431 ± 0.381
3.431GluArg: 3.431 ± 2.441
6.861GluSer: 6.861 ± 1.686
3.431GluThr: 3.431 ± 2.003
0.858GluVal: 0.858 ± 0.877
1.715GluTrp: 1.715 ± 0.673
4.288GluTyr: 4.288 ± 0.991
0.0GluXaa: 0.0 ± 0.0
Phe
5.146PheAla: 5.146 ± 0.97
0.0PheCys: 0.0 ± 0.0
2.573PheAsp: 2.573 ± 0.94
3.431PheGlu: 3.431 ± 2.003
0.0PhePhe: 0.0 ± 0.0
2.573PheGly: 2.573 ± 1.559
0.858PheHis: 0.858 ± 0.61
4.288PheIle: 4.288 ± 1.994
0.0PheLys: 0.0 ± 0.0
3.431PheLeu: 3.431 ± 1.346
1.715PheMet: 1.715 ± 0.743
1.715PheAsn: 1.715 ± 0.673
4.288PhePro: 4.288 ± 1.069
0.858PheGln: 0.858 ± 0.877
4.288PheArg: 4.288 ± 0.703
0.858PheSer: 0.858 ± 0.719
5.146PheThr: 5.146 ± 2.309
1.715PheVal: 1.715 ± 0.84
0.0PheTrp: 0.0 ± 0.0
0.858PheTyr: 0.858 ± 0.61
0.0PheXaa: 0.0 ± 0.0
Gly
5.146GlyAla: 5.146 ± 0.459
0.858GlyCys: 0.858 ± 0.719
2.573GlyAsp: 2.573 ± 1.329
1.715GlyGlu: 1.715 ± 0.673
1.715GlyPhe: 1.715 ± 0.673
1.715GlyGly: 1.715 ± 0.84
0.0GlyHis: 0.0 ± 0.0
4.288GlyIle: 4.288 ± 2.701
1.715GlyLys: 1.715 ± 0.673
5.146GlyLeu: 5.146 ± 2.309
0.858GlyMet: 0.858 ± 0.719
3.431GlyAsn: 3.431 ± 0.828
1.715GlyPro: 1.715 ± 0.84
0.858GlyGln: 0.858 ± 0.61
1.715GlyArg: 1.715 ± 1.753
6.003GlySer: 6.003 ± 2.409
3.431GlyThr: 3.431 ± 2.386
2.573GlyVal: 2.573 ± 0.94
0.858GlyTrp: 0.858 ± 0.61
3.431GlyTyr: 3.431 ± 0.381
0.0GlyXaa: 0.0 ± 0.0
His
0.858HisAla: 0.858 ± 0.61
0.0HisCys: 0.0 ± 0.0
0.0HisAsp: 0.0 ± 0.0
3.431HisGlu: 3.431 ± 0.381
0.858HisPhe: 0.858 ± 0.61
2.573HisGly: 2.573 ± 0.23
1.715HisHis: 1.715 ± 1.221
0.858HisIle: 0.858 ± 0.877
0.858HisLys: 0.858 ± 0.61
4.288HisLeu: 4.288 ± 1.843
0.0HisMet: 0.0 ± 0.0
0.858HisAsn: 0.858 ± 0.719
0.0HisPro: 0.0 ± 0.0
0.0HisGln: 0.0 ± 0.0
2.573HisArg: 2.573 ± 0.23
0.858HisSer: 0.858 ± 0.719
0.0HisThr: 0.0 ± 0.0
1.715HisVal: 1.715 ± 1.221
0.0HisTrp: 0.0 ± 0.0
3.431HisTyr: 3.431 ± 1.434
0.0HisXaa: 0.0 ± 0.0
Ile
6.003IleAla: 6.003 ± 1.479
0.858IleCys: 0.858 ± 0.877
2.573IleAsp: 2.573 ± 0.94
3.431IleGlu: 3.431 ± 0.381
0.858IlePhe: 0.858 ± 0.61
5.146IleGly: 5.146 ± 0.459
1.715IleHis: 1.715 ± 0.84
2.573IleIle: 2.573 ± 1.154
3.431IleLys: 3.431 ± 1.434
2.573IleLeu: 2.573 ± 1.154
2.573IleMet: 2.573 ± 0.23
1.715IleAsn: 1.715 ± 1.221
8.576IlePro: 8.576 ± 1.432
3.431IleGln: 3.431 ± 0.381
5.146IleArg: 5.146 ± 0.803
1.715IleSer: 1.715 ± 0.743
2.573IleThr: 2.573 ± 0.23
4.288IleVal: 4.288 ± 2.346
0.858IleTrp: 0.858 ± 0.719
1.715IleTyr: 1.715 ± 1.221
0.0IleXaa: 0.0 ± 0.0
Lys
1.715LysAla: 1.715 ± 0.743
0.0LysCys: 0.0 ± 0.0
2.573LysAsp: 2.573 ± 0.23
3.431LysGlu: 3.431 ± 1.68
1.715LysPhe: 1.715 ± 0.743
0.858LysGly: 0.858 ± 0.719
0.0LysHis: 0.0 ± 0.0
6.003LysIle: 6.003 ± 2.15
0.0LysLys: 0.0 ± 0.0
5.146LysLeu: 5.146 ± 1.771
0.0LysMet: 0.0 ± 0.0
2.573LysAsn: 2.573 ± 0.23
0.0LysPro: 0.0 ± 0.0
0.0LysGln: 0.0 ± 0.0
3.431LysArg: 3.431 ± 1.044
4.288LysSer: 4.288 ± 1.516
3.431LysThr: 3.431 ± 1.044
3.431LysVal: 3.431 ± 1.434
0.858LysTrp: 0.858 ± 0.61
1.715LysTyr: 1.715 ± 1.221
0.0LysXaa: 0.0 ± 0.0
Leu
7.719LeuAla: 7.719 ± 1.7
0.858LeuCys: 0.858 ± 0.61
5.146LeuAsp: 5.146 ± 0.459
8.576LeuGlu: 8.576 ± 3.033
4.288LeuPhe: 4.288 ± 0.664
4.288LeuGly: 4.288 ± 2.592
1.715LeuHis: 1.715 ± 1.221
5.146LeuIle: 5.146 ± 1.602
8.576LeuLys: 8.576 ± 0.081
9.434LeuLeu: 9.434 ± 0.946
0.858LeuMet: 0.858 ± 0.719
6.003LeuAsn: 6.003 ± 1.358
4.288LeuPro: 4.288 ± 0.664
1.715LeuGln: 1.715 ± 1.438
6.861LeuArg: 6.861 ± 0.762
9.434LeuSer: 9.434 ± 1.38
6.861LeuThr: 6.861 ± 2.745
4.288LeuVal: 4.288 ± 1.069
0.0LeuTrp: 0.0 ± 0.0
4.288LeuTyr: 4.288 ± 1.914
0.0LeuXaa: 0.0 ± 0.0
Met
1.715MetAla: 1.715 ± 1.438
0.858MetCys: 0.858 ± 0.719
1.715MetAsp: 1.715 ± 1.221
0.858MetGlu: 0.858 ± 0.61
0.858MetPhe: 0.858 ± 0.61
0.0MetGly: 0.0 ± 0.0
0.858MetHis: 0.858 ± 0.61
0.858MetIle: 0.858 ± 0.877
2.573MetLys: 2.573 ± 1.329
0.858MetLeu: 0.858 ± 0.61
1.715MetMet: 1.715 ± 1.438
1.715MetAsn: 1.715 ± 0.743
0.858MetPro: 0.858 ± 0.719
1.715MetGln: 1.715 ± 1.438
1.715MetArg: 1.715 ± 0.84
2.573MetSer: 2.573 ± 1.439
0.858MetThr: 0.858 ± 0.877
0.858MetVal: 0.858 ± 0.877
0.0MetTrp: 0.0 ± 0.0
0.858MetTyr: 0.858 ± 0.61
0.0MetXaa: 0.0 ± 0.0
Asn
3.431AsnAla: 3.431 ± 0.828
0.858AsnCys: 0.858 ± 0.877
0.0AsnAsp: 0.0 ± 0.0
1.715AsnGlu: 1.715 ± 1.438
0.858AsnPhe: 0.858 ± 0.719
1.715AsnGly: 1.715 ± 0.673
0.858AsnHis: 0.858 ± 0.61
2.573AsnIle: 2.573 ± 1.154
0.858AsnLys: 0.858 ± 0.877
3.431AsnLeu: 3.431 ± 1.918
0.858AsnMet: 0.858 ± 0.765
2.573AsnAsn: 2.573 ± 2.63
3.431AsnPro: 3.431 ± 1.68
0.858AsnGln: 0.858 ± 0.719
1.715AsnArg: 1.715 ± 1.221
1.715AsnSer: 1.715 ± 1.221
1.715AsnThr: 1.715 ± 0.84
8.576AsnVal: 8.576 ± 0.081
0.858AsnTrp: 0.858 ± 0.61
4.288AsnTyr: 4.288 ± 1.843
0.0AsnXaa: 0.0 ± 0.0
Pro
2.573ProAla: 2.573 ± 1.295
0.858ProCys: 0.858 ± 0.719
0.858ProAsp: 0.858 ± 0.61
6.003ProGlu: 6.003 ± 2.409
0.0ProPhe: 0.0 ± 0.0
2.573ProGly: 2.573 ± 0.23
2.573ProHis: 2.573 ± 1.295
1.715ProIle: 1.715 ± 1.438
3.431ProLys: 3.431 ± 1.044
6.861ProLeu: 6.861 ± 2.431
1.715ProMet: 1.715 ± 0.743
2.573ProAsn: 2.573 ± 1.329
1.715ProPro: 1.715 ± 0.84
1.715ProGln: 1.715 ± 1.438
2.573ProArg: 2.573 ± 1.295
6.003ProSer: 6.003 ± 0.152
4.288ProThr: 4.288 ± 1.914
5.146ProVal: 5.146 ± 1.771
0.0ProTrp: 0.0 ± 0.0
2.573ProTyr: 2.573 ± 1.154
0.0ProXaa: 0.0 ± 0.0
Gln
2.573GlnAla: 2.573 ± 1.559
0.0GlnCys: 0.0 ± 0.0
0.858GlnAsp: 0.858 ± 0.61
1.715GlnGlu: 1.715 ± 0.84
4.288GlnPhe: 4.288 ± 0.664
0.858GlnGly: 0.858 ± 0.61
3.431GlnHis: 3.431 ± 0.381
0.858GlnIle: 0.858 ± 0.61
0.858GlnLys: 0.858 ± 0.719
3.431GlnLeu: 3.431 ± 2.003
1.715GlnMet: 1.715 ± 1.034
2.573GlnAsn: 2.573 ± 1.295
4.288GlnPro: 4.288 ± 1.534
1.715GlnGln: 1.715 ± 1.438
0.0GlnArg: 0.0 ± 0.0
1.715GlnSer: 1.715 ± 0.84
3.431GlnThr: 3.431 ± 2.386
0.858GlnVal: 0.858 ± 0.61
0.0GlnTrp: 0.0 ± 0.0
0.858GlnTyr: 0.858 ± 0.61
0.0GlnXaa: 0.0 ± 0.0
Arg
5.146ArgAla: 5.146 ± 2.229
0.0ArgCys: 0.0 ± 0.0
4.288ArgAsp: 4.288 ± 1.843
1.715ArgGlu: 1.715 ± 1.221
4.288ArgPhe: 4.288 ± 1.843
2.573ArgGly: 2.573 ± 0.94
1.715ArgHis: 1.715 ± 0.84
5.146ArgIle: 5.146 ± 1.602
4.288ArgLys: 4.288 ± 2.069
6.003ArgLeu: 6.003 ± 1.479
1.715ArgMet: 1.715 ± 0.743
1.715ArgAsn: 1.715 ± 1.221
2.573ArgPro: 2.573 ± 0.23
1.715ArgGln: 1.715 ± 0.673
4.288ArgArg: 4.288 ± 0.991
5.146ArgSer: 5.146 ± 1.543
6.003ArgThr: 6.003 ± 3.718
0.858ArgVal: 0.858 ± 0.877
0.858ArgTrp: 0.858 ± 0.61
2.573ArgTyr: 2.573 ± 1.439
0.0ArgXaa: 0.0 ± 0.0
Ser
4.288SerAla: 4.288 ± 2.069
0.858SerCys: 0.858 ± 0.61
5.146SerAsp: 5.146 ± 1.602
2.573SerGlu: 2.573 ± 1.154
4.288SerPhe: 4.288 ± 1.914
4.288SerGly: 4.288 ± 0.991
2.573SerHis: 2.573 ± 1.831
5.146SerIle: 5.146 ± 0.459
1.715SerLys: 1.715 ± 0.743
9.434SerLeu: 9.434 ± 0.732
0.858SerMet: 0.858 ± 0.877
4.288SerAsn: 4.288 ± 2.06
2.573SerPro: 2.573 ± 0.23
3.431SerGln: 3.431 ± 1.346
2.573SerArg: 2.573 ± 0.94
4.288SerSer: 4.288 ± 1.843
4.288SerThr: 4.288 ± 1.843
2.573SerVal: 2.573 ± 0.94
0.858SerTrp: 0.858 ± 0.61
5.146SerTyr: 5.146 ± 2.789
0.0SerXaa: 0.0 ± 0.0
Thr
8.576ThrAla: 8.576 ± 3.829
0.858ThrCys: 0.858 ± 0.61
2.573ThrAsp: 2.573 ± 1.559
3.431ThrGlu: 3.431 ± 1.68
6.003ThrPhe: 6.003 ± 2.583
2.573ThrGly: 2.573 ± 1.559
3.431ThrHis: 3.431 ± 0.381
3.431ThrIle: 3.431 ± 0.381
1.715ThrLys: 1.715 ± 1.753
6.003ThrLeu: 6.003 ± 1.232
0.858ThrMet: 0.858 ± 0.61
4.288ThrAsn: 4.288 ± 0.991
2.573ThrPro: 2.573 ± 1.439
3.431ThrGln: 3.431 ± 0.381
6.003ThrArg: 6.003 ± 1.391
0.0ThrSer: 0.0 ± 0.0
2.573ThrThr: 2.573 ± 0.23
2.573ThrVal: 2.573 ± 2.157
0.858ThrTrp: 0.858 ± 0.719
1.715ThrTyr: 1.715 ± 1.753
0.0ThrXaa: 0.0 ± 0.0
Val
4.288ValAla: 4.288 ± 1.534
2.573ValCys: 2.573 ± 0.23
4.288ValAsp: 4.288 ± 1.069
4.288ValGlu: 4.288 ± 2.03
3.431ValPhe: 3.431 ± 0.381
0.858ValGly: 0.858 ± 0.61
0.858ValHis: 0.858 ± 0.61
1.715ValIle: 1.715 ± 1.753
2.573ValLys: 2.573 ± 1.329
3.431ValLeu: 3.431 ± 2.286
2.573ValMet: 2.573 ± 0.394
1.715ValAsn: 1.715 ± 0.84
5.146ValPro: 5.146 ± 0.459
2.573ValGln: 2.573 ± 1.439
4.288ValArg: 4.288 ± 3.052
4.288ValSer: 4.288 ± 1.994
4.288ValThr: 4.288 ± 0.703
3.431ValVal: 3.431 ± 1.918
1.715ValTrp: 1.715 ± 1.221
1.715ValTyr: 1.715 ± 0.673
0.0ValXaa: 0.0 ± 0.0
Trp
0.858TrpAla: 0.858 ± 0.61
0.0TrpCys: 0.0 ± 0.0
0.858TrpAsp: 0.858 ± 0.61
0.858TrpGlu: 0.858 ± 0.61
0.0TrpPhe: 0.0 ± 0.0
0.858TrpGly: 0.858 ± 0.61
0.0TrpHis: 0.0 ± 0.0
0.0TrpIle: 0.0 ± 0.0
0.0TrpLys: 0.0 ± 0.0
0.858TrpLeu: 0.858 ± 0.719
0.0TrpMet: 0.0 ± 0.0
0.858TrpAsn: 0.858 ± 0.719
0.0TrpPro: 0.0 ± 0.0
0.0TrpGln: 0.0 ± 0.0
1.715TrpArg: 1.715 ± 1.221
2.573TrpSer: 2.573 ± 0.23
1.715TrpThr: 1.715 ± 0.673
1.715TrpVal: 1.715 ± 1.221
1.715TrpTrp: 1.715 ± 0.84
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
4.288TyrAla: 4.288 ± 0.703
0.0TyrCys: 0.0 ± 0.0
0.858TyrAsp: 0.858 ± 0.61
2.573TyrGlu: 2.573 ± 1.154
1.715TyrPhe: 1.715 ± 0.673
3.431TyrGly: 3.431 ± 0.381
0.858TyrHis: 0.858 ± 0.61
1.715TyrIle: 1.715 ± 0.743
2.573TyrLys: 2.573 ± 0.94
4.288TyrLeu: 4.288 ± 0.991
0.858TyrMet: 0.858 ± 0.61
0.858TyrAsn: 0.858 ± 0.719
4.288TyrPro: 4.288 ± 0.703
2.573TyrGln: 2.573 ± 1.295
2.573TyrArg: 2.573 ± 1.439
1.715TyrSer: 1.715 ± 0.673
2.573TyrThr: 2.573 ± 1.439
5.146TyrVal: 5.146 ± 2.577
0.0TyrTrp: 0.0 ± 0.0
1.715TyrTyr: 1.715 ± 0.673
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3 proteins (1167 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski