Amino acid dipepetide frequency for Labilibaculum antarcticum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.871AlaAla: 3.871 ± 0.076	0.739AlaCys: 0.739 ± 0.023	3.588AlaAsp: 3.588 ± 0.057	4.128AlaGlu: 4.128 ± 0.055	3.173AlaPhe: 3.173 ± 0.047	4.474AlaGly: 4.474 ± 0.067	1.075AlaHis: 1.075 ± 0.027	5.306AlaIle: 5.306 ± 0.066	4.79AlaLys: 4.79 ± 0.064	5.751AlaLeu: 5.751 ± 0.072	1.597AlaMet: 1.597 ± 0.04	3.468AlaAsn: 3.468 ± 0.064	1.771AlaPro: 1.771 ± 0.043	2.104AlaGln: 2.104 ± 0.035	2.044AlaArg: 2.044 ± 0.037	4.141AlaSer: 4.141 ± 0.06	3.206AlaThr: 3.206 ± 0.074	3.942AlaVal: 3.942 ± 0.055	0.669AlaTrp: 0.669 ± 0.023	2.504AlaTyr: 2.504 ± 0.038	0.0AlaXaa: 0.0 ± 0.0
Cys	0.567CysAla: 0.567 ± 0.02	0.132CysCys: 0.132 ± 0.01	0.571CysAsp: 0.571 ± 0.02	0.618CysGlu: 0.618 ± 0.021	0.519CysPhe: 0.519 ± 0.019	0.77CysGly: 0.77 ± 0.028	0.241CysHis: 0.241 ± 0.019	0.71CysIle: 0.71 ± 0.022	0.641CysLys: 0.641 ± 0.022	0.821CysLeu: 0.821 ± 0.028	0.221CysMet: 0.221 ± 0.013	0.534CysAsn: 0.534 ± 0.022	0.401CysPro: 0.401 ± 0.017	0.296CysGln: 0.296 ± 0.015	0.326CysArg: 0.326 ± 0.014	0.753CysSer: 0.753 ± 0.038	0.518CysThr: 0.518 ± 0.023	0.564CysVal: 0.564 ± 0.019	0.091CysTrp: 0.091 ± 0.008	0.363CysTyr: 0.363 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	3.553AspAla: 3.553 ± 0.074	0.556AspCys: 0.556 ± 0.02	2.896AspAsp: 2.896 ± 0.047	3.995AspGlu: 3.995 ± 0.046	3.506AspPhe: 3.506 ± 0.053	3.84AspGly: 3.84 ± 0.064	1.0AspHis: 1.0 ± 0.024	4.436AspIle: 4.436 ± 0.058	4.158AspLys: 4.158 ± 0.057	5.777AspLeu: 5.777 ± 0.064	1.269AspMet: 1.269 ± 0.031	2.886AspAsn: 2.886 ± 0.049	1.809AspPro: 1.809 ± 0.03	2.013AspGln: 2.013 ± 0.049	2.119AspArg: 2.119 ± 0.041	3.48AspSer: 3.48 ± 0.048	2.341AspThr: 2.341 ± 0.039	3.707AspVal: 3.707 ± 0.054	0.826AspTrp: 0.826 ± 0.025	2.742AspTyr: 2.742 ± 0.042	0.0AspXaa: 0.0 ± 0.0
Glu	4.207GluAla: 4.207 ± 0.059	0.511GluCys: 0.511 ± 0.018	3.561GluAsp: 3.561 ± 0.048	5.01GluGlu: 5.01 ± 0.067	3.314GluPhe: 3.314 ± 0.049	3.94GluGly: 3.94 ± 0.055	1.054GluHis: 1.054 ± 0.024	5.951GluIle: 5.951 ± 0.072	6.3GluLys: 6.3 ± 0.074	7.006GluLeu: 7.006 ± 0.069	2.037GluMet: 2.037 ± 0.04	4.647GluAsn: 4.647 ± 0.062	1.495GluPro: 1.495 ± 0.036	2.262GluGln: 2.262 ± 0.041	2.398GluArg: 2.398 ± 0.044	3.94GluSer: 3.94 ± 0.053	3.199GluThr: 3.199 ± 0.052	4.183GluVal: 4.183 ± 0.052	0.78GluTrp: 0.78 ± 0.024	2.744GluTyr: 2.744 ± 0.044	0.0GluXaa: 0.0 ± 0.0
Phe	3.195PheAla: 3.195 ± 0.047	0.511PheCys: 0.511 ± 0.017	3.24PheAsp: 3.24 ± 0.047	3.398PheGlu: 3.398 ± 0.051	2.475PhePhe: 2.475 ± 0.05	3.446PheGly: 3.446 ± 0.055	0.888PheHis: 0.888 ± 0.021	3.759PheIle: 3.759 ± 0.063	3.368PheLys: 3.368 ± 0.052	4.528PheLeu: 4.528 ± 0.071	1.165PheMet: 1.165 ± 0.03	2.791PheAsn: 2.791 ± 0.042	1.697PhePro: 1.697 ± 0.032	1.545PheGln: 1.545 ± 0.036	1.695PheArg: 1.695 ± 0.031	4.163PheSer: 4.163 ± 0.055	3.063PheThr: 3.063 ± 0.047	3.109PheVal: 3.109 ± 0.049	0.619PheTrp: 0.619 ± 0.021	2.013PheTyr: 2.013 ± 0.037	0.0PheXaa: 0.0 ± 0.0
Gly	4.178GlyAla: 4.178 ± 0.056	0.727GlyCys: 0.727 ± 0.034	3.585GlyAsp: 3.585 ± 0.051	4.193GlyGlu: 4.193 ± 0.065	3.569GlyPhe: 3.569 ± 0.053	4.507GlyGly: 4.507 ± 0.078	1.086GlyHis: 1.086 ± 0.029	5.813GlyIle: 5.813 ± 0.078	5.345GlyLys: 5.345 ± 0.064	5.903GlyLeu: 5.903 ± 0.078	1.798GlyMet: 1.798 ± 0.034	3.807GlyAsn: 3.807 ± 0.09	1.337GlyPro: 1.337 ± 0.031	1.8GlyGln: 1.8 ± 0.033	2.185GlyArg: 2.185 ± 0.035	4.161GlySer: 4.161 ± 0.079	3.723GlyThr: 3.723 ± 0.08	4.536GlyVal: 4.536 ± 0.061	0.801GlyTrp: 0.801 ± 0.023	2.848GlyTyr: 2.848 ± 0.047	0.0GlyXaa: 0.0 ± 0.0
His	0.984HisAla: 0.984 ± 0.03	0.222HisCys: 0.222 ± 0.011	0.925HisAsp: 0.925 ± 0.028	1.07HisGlu: 1.07 ± 0.027	1.11HisPhe: 1.11 ± 0.028	1.121HisGly: 1.121 ± 0.032	0.433HisHis: 0.433 ± 0.018	1.294HisIle: 1.294 ± 0.027	1.172HisLys: 1.172 ± 0.028	1.829HisLeu: 1.829 ± 0.034	0.38HisMet: 0.38 ± 0.016	0.888HisAsn: 0.888 ± 0.023	0.9HisPro: 0.9 ± 0.025	0.625HisGln: 0.625 ± 0.02	0.673HisArg: 0.673 ± 0.022	1.144HisSer: 1.144 ± 0.027	0.863HisThr: 0.863 ± 0.024	0.941HisVal: 0.941 ± 0.025	0.217HisTrp: 0.217 ± 0.012	0.784HisTyr: 0.784 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	5.433IleAla: 5.433 ± 0.07	0.834IleCys: 0.834 ± 0.025	4.85IleAsp: 4.85 ± 0.066	5.622IleGlu: 5.622 ± 0.078	3.517IlePhe: 3.517 ± 0.043	5.325IleGly: 5.325 ± 0.059	1.518IleHis: 1.518 ± 0.034	5.824IleIle: 5.824 ± 0.08	5.538IleLys: 5.538 ± 0.072	7.291IleLeu: 7.291 ± 0.085	1.534IleMet: 1.534 ± 0.036	4.383IleAsn: 4.383 ± 0.054	3.274IlePro: 3.274 ± 0.05	2.758IleGln: 2.758 ± 0.039	3.053IleArg: 3.053 ± 0.048	6.188IleSer: 6.188 ± 0.077	4.406IleThr: 4.406 ± 0.079	4.934IleVal: 4.934 ± 0.061	0.811IleTrp: 0.811 ± 0.027	2.827IleTyr: 2.827 ± 0.043	0.0IleXaa: 0.0 ± 0.0
Lys	4.846LysAla: 4.846 ± 0.073	0.501LysCys: 0.501 ± 0.02	4.408LysAsp: 4.408 ± 0.064	6.509LysGlu: 6.509 ± 0.077	2.984LysPhe: 2.984 ± 0.046	4.875LysGly: 4.875 ± 0.065	1.287LysHis: 1.287 ± 0.031	6.243LysIle: 6.243 ± 0.078	6.33LysLys: 6.33 ± 0.083	6.736LysLeu: 6.736 ± 0.069	2.269LysMet: 2.269 ± 0.039	4.835LysAsn: 4.835 ± 0.07	2.188LysPro: 2.188 ± 0.04	2.59LysGln: 2.59 ± 0.046	2.843LysArg: 2.843 ± 0.044	4.793LysSer: 4.793 ± 0.063	4.101LysThr: 4.101 ± 0.056	4.55LysVal: 4.55 ± 0.062	0.89LysTrp: 0.89 ± 0.023	3.286LysTyr: 3.286 ± 0.045	0.0LysXaa: 0.0 ± 0.0
Leu	6.063LeuAla: 6.063 ± 0.069	0.854LeuCys: 0.854 ± 0.026	5.031LeuAsp: 5.031 ± 0.062	6.012LeuGlu: 6.012 ± 0.06	4.87LeuPhe: 4.87 ± 0.071	5.928LeuGly: 5.928 ± 0.081	1.597LeuHis: 1.597 ± 0.038	7.257LeuIle: 7.257 ± 0.084	7.583LeuLys: 7.583 ± 0.077	9.196LeuLeu: 9.196 ± 0.121	2.14LeuMet: 2.14 ± 0.041	5.538LeuAsn: 5.538 ± 0.064	3.497LeuPro: 3.497 ± 0.049	3.054LeuGln: 3.054 ± 0.054	3.298LeuArg: 3.298 ± 0.045	7.101LeuSer: 7.101 ± 0.074	4.691LeuThr: 4.691 ± 0.063	5.506LeuVal: 5.506 ± 0.054	0.909LeuTrp: 0.909 ± 0.036	3.164LeuTyr: 3.164 ± 0.048	0.0LeuXaa: 0.0 ± 0.0
Met	1.711MetAla: 1.711 ± 0.038	0.187MetCys: 0.187 ± 0.01	1.518MetAsp: 1.518 ± 0.031	1.607MetGlu: 1.607 ± 0.033	0.923MetPhe: 0.923 ± 0.024	1.791MetGly: 1.791 ± 0.036	0.412MetHis: 0.412 ± 0.016	1.809MetIle: 1.809 ± 0.039	2.224MetLys: 2.224 ± 0.036	2.066MetLeu: 2.066 ± 0.039	0.625MetMet: 0.625 ± 0.019	1.573MetAsn: 1.573 ± 0.03	0.925MetPro: 0.925 ± 0.027	0.815MetGln: 0.815 ± 0.021	0.89MetArg: 0.89 ± 0.025	1.451MetSer: 1.451 ± 0.035	1.133MetThr: 1.133 ± 0.028	1.524MetVal: 1.524 ± 0.032	0.208MetTrp: 0.208 ± 0.012	0.73MetTyr: 0.73 ± 0.024	0.0MetXaa: 0.0 ± 0.0
Asn	3.432AsnAla: 3.432 ± 0.053	0.595AsnCys: 0.595 ± 0.021	2.955AsnAsp: 2.955 ± 0.042	3.761AsnGlu: 3.761 ± 0.054	2.802AsnPhe: 2.802 ± 0.042	3.973AsnGly: 3.973 ± 0.073	1.06AsnHis: 1.06 ± 0.027	4.558AsnIle: 4.558 ± 0.064	4.298AsnLys: 4.298 ± 0.062	5.519AsnLeu: 5.519 ± 0.059	1.335AsnMet: 1.335 ± 0.028	3.247AsnAsn: 3.247 ± 0.054	2.606AsnPro: 2.606 ± 0.045	2.305AsnGln: 2.305 ± 0.039	2.263AsnArg: 2.263 ± 0.041	4.103AsnSer: 4.103 ± 0.06	3.052AsnThr: 3.052 ± 0.05	3.174AsnVal: 3.174 ± 0.043	0.826AsnTrp: 0.826 ± 0.025	2.677AsnTyr: 2.677 ± 0.048	0.0AsnXaa: 0.0 ± 0.0
Pro	2.007ProAla: 2.007 ± 0.033	0.262ProCys: 0.262 ± 0.013	2.168ProAsp: 2.168 ± 0.033	2.934ProGlu: 2.934 ± 0.042	1.835ProPhe: 1.835 ± 0.034	1.967ProGly: 1.967 ± 0.033	0.619ProHis: 0.619 ± 0.021	2.605ProIle: 2.605 ± 0.042	2.369ProLys: 2.369 ± 0.045	2.75ProLeu: 2.75 ± 0.043	0.763ProMet: 0.763 ± 0.022	2.055ProAsn: 2.055 ± 0.037	0.74ProPro: 0.74 ± 0.022	1.025ProGln: 1.025 ± 0.026	0.94ProArg: 0.94 ± 0.023	2.074ProSer: 2.074 ± 0.036	1.689ProThr: 1.689 ± 0.037	2.457ProVal: 2.457 ± 0.048	0.361ProTrp: 0.361 ± 0.016	1.334ProTyr: 1.334 ± 0.029	0.0ProXaa: 0.0 ± 0.0
Gln	2.036GlnAla: 2.036 ± 0.038	0.213GlnCys: 0.213 ± 0.013	1.667GlnAsp: 1.667 ± 0.036	2.412GlnGlu: 2.412 ± 0.049	1.783GlnPhe: 1.783 ± 0.035	1.738GlnGly: 1.738 ± 0.037	0.523GlnHis: 0.523 ± 0.019	2.939GlnIle: 2.939 ± 0.048	2.937GlnLys: 2.937 ± 0.047	3.354GlnLeu: 3.354 ± 0.052	0.883GlnMet: 0.883 ± 0.028	2.194GlnAsn: 2.194 ± 0.049	0.927GlnPro: 0.927 ± 0.027	1.208GlnGln: 1.208 ± 0.03	1.104GlnArg: 1.104 ± 0.025	2.014GlnSer: 2.014 ± 0.036	1.7GlnThr: 1.7 ± 0.045	1.938GlnVal: 1.938 ± 0.034	0.348GlnTrp: 0.348 ± 0.017	1.295GlnTyr: 1.295 ± 0.029	0.0GlnXaa: 0.0 ± 0.0
Arg	2.022ArgAla: 2.022 ± 0.041	0.279ArgCys: 0.279 ± 0.014	1.868ArgAsp: 1.868 ± 0.033	2.417ArgGlu: 2.417 ± 0.041	1.924ArgPhe: 1.924 ± 0.036	2.007ArgGly: 2.007 ± 0.035	0.591ArgHis: 0.591 ± 0.02	3.155ArgIle: 3.155 ± 0.056	3.143ArgLys: 3.143 ± 0.053	3.268ArgLeu: 3.268 ± 0.047	1.045ArgMet: 1.045 ± 0.025	2.204ArgAsn: 2.204 ± 0.037	1.084ArgPro: 1.084 ± 0.03	1.049ArgGln: 1.049 ± 0.026	1.366ArgArg: 1.366 ± 0.031	2.122ArgSer: 2.122 ± 0.041	1.896ArgThr: 1.896 ± 0.035	2.124ArgVal: 2.124 ± 0.033	0.462ArgTrp: 0.462 ± 0.025	1.525ArgTyr: 1.525 ± 0.035	0.0ArgXaa: 0.0 ± 0.0
Ser	3.989SerAla: 3.989 ± 0.062	0.772SerCys: 0.772 ± 0.023	3.996SerAsp: 3.996 ± 0.053	4.567SerGlu: 4.567 ± 0.06	3.868SerPhe: 3.868 ± 0.054	4.889SerGly: 4.889 ± 0.074	1.193SerHis: 1.193 ± 0.026	5.701SerIle: 5.701 ± 0.065	5.006SerLys: 5.006 ± 0.067	6.368SerLeu: 6.368 ± 0.067	1.537SerMet: 1.537 ± 0.032	3.833SerAsn: 3.833 ± 0.063	2.112SerPro: 2.112 ± 0.037	2.116SerGln: 2.116 ± 0.036	2.307SerArg: 2.307 ± 0.042	4.725SerSer: 4.725 ± 0.065	3.38SerThr: 3.38 ± 0.076	4.388SerVal: 4.388 ± 0.059	0.794SerTrp: 0.794 ± 0.024	2.886SerTyr: 2.886 ± 0.046	0.0SerXaa: 0.0 ± 0.0
Thr	3.307ThrAla: 3.307 ± 0.072	0.488ThrCys: 0.488 ± 0.027	3.302ThrAsp: 3.302 ± 0.066	3.207ThrGlu: 3.207 ± 0.043	2.377ThrPhe: 2.377 ± 0.047	3.98ThrGly: 3.98 ± 0.05	0.933ThrHis: 0.933 ± 0.027	4.412ThrIle: 4.412 ± 0.086	3.489ThrLys: 3.489 ± 0.054	4.475ThrLeu: 4.475 ± 0.061	0.936ThrMet: 0.936 ± 0.026	2.993ThrAsn: 2.993 ± 0.048	2.213ThrPro: 2.213 ± 0.038	1.66ThrGln: 1.66 ± 0.038	1.65ThrArg: 1.65 ± 0.035	3.558ThrSer: 3.558 ± 0.064	2.865ThrThr: 2.865 ± 0.059	3.249ThrVal: 3.249 ± 0.073	0.536ThrTrp: 0.536 ± 0.021	2.099ThrTyr: 2.099 ± 0.047	0.0ThrXaa: 0.0 ± 0.0
Val	3.931ValAla: 3.931 ± 0.054	0.693ValCys: 0.693 ± 0.022	3.832ValAsp: 3.832 ± 0.065	3.987ValGlu: 3.987 ± 0.056	3.261ValPhe: 3.261 ± 0.043	3.877ValGly: 3.877 ± 0.058	0.982ValHis: 0.982 ± 0.028	4.785ValIle: 4.785 ± 0.061	4.571ValLys: 4.571 ± 0.063	5.774ValLeu: 5.774 ± 0.065	1.387ValMet: 1.387 ± 0.026	3.605ValAsn: 3.605 ± 0.053	2.131ValPro: 2.131 ± 0.036	1.789ValGln: 1.789 ± 0.035	2.264ValArg: 2.264 ± 0.038	4.64ValSer: 4.64 ± 0.064	3.062ValThr: 3.062 ± 0.08	4.138ValVal: 4.138 ± 0.073	0.693ValTrp: 0.693 ± 0.022	2.271ValTyr: 2.271 ± 0.039	0.0ValXaa: 0.0 ± 0.0
Trp	0.675TrpAla: 0.675 ± 0.023	0.111TrpCys: 0.111 ± 0.009	0.745TrpAsp: 0.745 ± 0.024	0.792TrpGlu: 0.792 ± 0.021	0.544TrpPhe: 0.544 ± 0.019	0.846TrpGly: 0.846 ± 0.023	0.23TrpHis: 0.23 ± 0.013	0.884TrpIle: 0.884 ± 0.023	0.87TrpLys: 0.87 ± 0.026	0.987TrpLeu: 0.987 ± 0.027	0.361TrpMet: 0.361 ± 0.015	0.712TrpAsn: 0.712 ± 0.024	0.269TrpPro: 0.269 ± 0.014	0.417TrpGln: 0.417 ± 0.016	0.435TrpArg: 0.435 ± 0.017	0.721TrpSer: 0.721 ± 0.032	0.628TrpThr: 0.628 ± 0.032	0.678TrpVal: 0.678 ± 0.024	0.155TrpTrp: 0.155 ± 0.011	0.466TrpTyr: 0.466 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.329TyrAla: 2.329 ± 0.034	0.468TyrCys: 0.468 ± 0.017	2.202TyrAsp: 2.202 ± 0.044	2.302TyrGlu: 2.302 ± 0.037	2.313TyrPhe: 2.313 ± 0.043	2.61TyrGly: 2.61 ± 0.042	0.851TyrHis: 0.851 ± 0.024	2.479TyrIle: 2.479 ± 0.038	2.934TyrLys: 2.934 ± 0.047	3.887TyrLeu: 3.887 ± 0.058	0.842TyrMet: 0.842 ± 0.027	2.348TyrAsn: 2.348 ± 0.046	1.578TyrPro: 1.578 ± 0.031	1.783TyrGln: 1.783 ± 0.034	1.703TyrArg: 1.703 ± 0.035	3.158TyrSer: 3.158 ± 0.049	2.213TyrThr: 2.213 ± 0.044	2.029TyrVal: 2.029 ± 0.038	0.531TyrTrp: 0.531 ± 0.019	1.838TyrTyr: 1.838 ± 0.038	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4329 proteins (1607196 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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