Amino acid dipepetide frequency for Opisthorchis felineus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.974AlaAla: 5.974 ± 0.041	1.442AlaCys: 1.442 ± 0.014	3.589AlaAsp: 3.589 ± 0.02	4.193AlaGlu: 4.193 ± 0.03	2.541AlaPhe: 2.541 ± 0.018	3.785AlaGly: 3.785 ± 0.023	1.737AlaHis: 1.737 ± 0.014	3.189AlaIle: 3.189 ± 0.019	3.031AlaLys: 3.031 ± 0.021	6.321AlaLeu: 6.321 ± 0.034	1.407AlaMet: 1.407 ± 0.013	2.755AlaAsn: 2.755 ± 0.019	3.49AlaPro: 3.49 ± 0.028	2.729AlaGln: 2.729 ± 0.018	3.956AlaArg: 3.956 ± 0.023	6.416AlaSer: 6.416 ± 0.03	4.402AlaThr: 4.402 ± 0.023	4.848AlaVal: 4.848 ± 0.025	0.685AlaTrp: 0.685 ± 0.009	1.831AlaTyr: 1.831 ± 0.013	0.0AlaXaa: 0.0 ± 0.0
Cys	1.329CysAla: 1.329 ± 0.013	0.563CysCys: 0.563 ± 0.009	1.064CysAsp: 1.064 ± 0.014	1.122CysGlu: 1.122 ± 0.014	0.873CysPhe: 0.873 ± 0.01	1.324CysGly: 1.324 ± 0.014	0.622CysHis: 0.622 ± 0.009	1.059CysIle: 1.059 ± 0.013	0.781CysLys: 0.781 ± 0.009	2.309CysLeu: 2.309 ± 0.019	0.414CysMet: 0.414 ± 0.006	0.749CysAsn: 0.749 ± 0.01	1.277CysPro: 1.277 ± 0.016	0.888CysGln: 0.888 ± 0.012	1.372CysArg: 1.372 ± 0.013	1.947CysSer: 1.947 ± 0.017	1.229CysThr: 1.229 ± 0.011	1.41CysVal: 1.41 ± 0.016	0.271CysTrp: 0.271 ± 0.005	0.545CysTyr: 0.545 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	3.601AspAla: 3.601 ± 0.018	1.089AspCys: 1.089 ± 0.011	3.037AspAsp: 3.037 ± 0.027	3.72AspGlu: 3.72 ± 0.023	1.962AspPhe: 1.962 ± 0.016	3.238AspGly: 3.238 ± 0.024	1.242AspHis: 1.242 ± 0.011	2.413AspIle: 2.413 ± 0.016	2.107AspLys: 2.107 ± 0.015	5.044AspLeu: 5.044 ± 0.024	0.999AspMet: 0.999 ± 0.011	1.848AspAsn: 1.848 ± 0.017	3.049AspPro: 3.049 ± 0.017	2.192AspGln: 2.192 ± 0.015	3.222AspArg: 3.222 ± 0.017	4.784AspSer: 4.784 ± 0.023	2.895AspThr: 2.895 ± 0.015	3.407AspVal: 3.407 ± 0.023	0.702AspTrp: 0.702 ± 0.008	1.491AspTyr: 1.491 ± 0.014	0.0AspXaa: 0.0 ± 0.0
Glu	4.341GluAla: 4.341 ± 0.026	1.103GluCys: 1.103 ± 0.014	3.335GluAsp: 3.335 ± 0.02	4.49GluGlu: 4.49 ± 0.033	2.19GluPhe: 2.19 ± 0.013	2.484GluGly: 2.484 ± 0.02	1.61GluHis: 1.61 ± 0.013	2.657GluIle: 2.657 ± 0.019	3.1GluLys: 3.1 ± 0.025	6.345GluLeu: 6.345 ± 0.036	1.294GluMet: 1.294 ± 0.013	2.661GluAsn: 2.661 ± 0.018	2.924GluPro: 2.924 ± 0.023	2.898GluGln: 2.898 ± 0.021	3.894GluArg: 3.894 ± 0.022	4.596GluSer: 4.596 ± 0.024	3.499GluThr: 3.499 ± 0.02	3.534GluVal: 3.534 ± 0.028	0.618GluTrp: 0.618 ± 0.008	1.526GluTyr: 1.526 ± 0.014	0.0GluXaa: 0.0 ± 0.0
Phe	2.38PheAla: 2.38 ± 0.016	0.883PheCys: 0.883 ± 0.009	2.066PheAsp: 2.066 ± 0.016	2.009PheGlu: 2.009 ± 0.014	1.431PhePhe: 1.431 ± 0.015	2.539PheGly: 2.539 ± 0.018	1.09PheHis: 1.09 ± 0.01	1.807PheIle: 1.807 ± 0.017	1.398PheLys: 1.398 ± 0.015	3.668PheLeu: 3.668 ± 0.027	0.716PheMet: 0.716 ± 0.01	1.429PheAsn: 1.429 ± 0.012	2.017PhePro: 2.017 ± 0.016	1.491PheGln: 1.491 ± 0.013	2.404PheArg: 2.404 ± 0.018	3.361PheSer: 3.361 ± 0.021	2.338PheThr: 2.338 ± 0.017	2.585PheVal: 2.585 ± 0.015	0.476PheTrp: 0.476 ± 0.007	1.16PheTyr: 1.16 ± 0.013	0.0PheXaa: 0.0 ± 0.0
Gly	3.485GlyAla: 3.485 ± 0.025	1.154GlyCys: 1.154 ± 0.012	2.936GlyAsp: 2.936 ± 0.024	2.926GlyGlu: 2.926 ± 0.03	2.221GlyPhe: 2.221 ± 0.019	3.532GlyGly: 3.532 ± 0.028	1.572GlyHis: 1.572 ± 0.013	2.689GlyIle: 2.689 ± 0.019	2.412GlyLys: 2.412 ± 0.016	5.476GlyLeu: 5.476 ± 0.028	1.134GlyMet: 1.134 ± 0.011	2.098GlyAsn: 2.098 ± 0.016	2.937GlyPro: 2.937 ± 0.045	2.372GlyGln: 2.372 ± 0.015	3.599GlyArg: 3.599 ± 0.024	5.468GlySer: 5.468 ± 0.035	3.562GlyThr: 3.562 ± 0.022	3.377GlyVal: 3.377 ± 0.022	0.652GlyTrp: 0.652 ± 0.008	1.647GlyTyr: 1.647 ± 0.017	0.0GlyXaa: 0.0 ± 0.0
His	1.637HisAla: 1.637 ± 0.014	0.667HisCys: 0.667 ± 0.01	1.084HisAsp: 1.084 ± 0.011	1.374HisGlu: 1.374 ± 0.011	1.109HisPhe: 1.109 ± 0.011	1.517HisGly: 1.517 ± 0.014	0.958HisHis: 0.958 ± 0.014	1.293HisIle: 1.293 ± 0.012	1.062HisLys: 1.062 ± 0.011	3.064HisLeu: 3.064 ± 0.019	0.565HisMet: 0.565 ± 0.008	0.978HisAsn: 0.978 ± 0.009	1.886HisPro: 1.886 ± 0.015	1.256HisGln: 1.256 ± 0.012	1.919HisArg: 1.919 ± 0.015	2.692HisSer: 2.692 ± 0.018	1.653HisThr: 1.653 ± 0.015	1.71HisVal: 1.71 ± 0.012	0.373HisTrp: 0.373 ± 0.005	0.793HisTyr: 0.793 ± 0.009	0.0HisXaa: 0.0 ± 0.0
Ile	2.93IleAla: 2.93 ± 0.019	1.085IleCys: 1.085 ± 0.012	2.349IleAsp: 2.349 ± 0.017	2.569IleGlu: 2.569 ± 0.02	1.798IlePhe: 1.798 ± 0.017	2.52IleGly: 2.52 ± 0.018	1.379IleHis: 1.379 ± 0.012	2.112IleIle: 2.112 ± 0.02	1.954IleLys: 1.954 ± 0.016	4.516IleLeu: 4.516 ± 0.027	0.885IleMet: 0.885 ± 0.011	1.851IleAsn: 1.851 ± 0.016	3.037IlePro: 3.037 ± 0.019	2.184IleGln: 2.184 ± 0.017	3.174IleArg: 3.174 ± 0.019	4.246IleSer: 4.246 ± 0.019	2.773IleThr: 2.773 ± 0.018	2.797IleVal: 2.797 ± 0.02	0.555IleTrp: 0.555 ± 0.008	1.368IleTyr: 1.368 ± 0.013	0.0IleXaa: 0.0 ± 0.0
Lys	2.928LysAla: 2.928 ± 0.02	0.854LysCys: 0.854 ± 0.011	2.098LysAsp: 2.098 ± 0.016	2.76LysGlu: 2.76 ± 0.02	1.472LysPhe: 1.472 ± 0.013	1.807LysGly: 1.807 ± 0.024	1.297LysHis: 1.297 ± 0.011	1.989LysIle: 1.989 ± 0.016	2.469LysLys: 2.469 ± 0.023	4.666LysLeu: 4.666 ± 0.025	0.952LysMet: 0.952 ± 0.011	1.73LysAsn: 1.73 ± 0.013	2.873LysPro: 2.873 ± 0.025	2.229LysGln: 2.229 ± 0.015	3.41LysArg: 3.41 ± 0.023	3.796LysSer: 3.796 ± 0.023	2.732LysThr: 2.732 ± 0.014	2.498LysVal: 2.498 ± 0.017	0.497LysTrp: 0.497 ± 0.007	1.182LysTyr: 1.182 ± 0.013	0.0LysXaa: 0.0 ± 0.0
Leu	6.914LeuAla: 6.914 ± 0.039	2.195LeuCys: 2.195 ± 0.018	5.306LeuAsp: 5.306 ± 0.027	5.881LeuGlu: 5.881 ± 0.031	3.808LeuPhe: 3.808 ± 0.024	4.994LeuGly: 4.994 ± 0.027	2.846LeuHis: 2.846 ± 0.023	4.573LeuIle: 4.573 ± 0.026	4.419LeuLys: 4.419 ± 0.023	10.497LeuLeu: 10.497 ± 0.061	1.908LeuMet: 1.908 ± 0.014	4.14LeuAsn: 4.14 ± 0.021	5.924LeuPro: 5.924 ± 0.032	4.422LeuGln: 4.422 ± 0.024	6.75LeuArg: 6.75 ± 0.03	9.143LeuSer: 9.143 ± 0.039	6.078LeuThr: 6.078 ± 0.028	6.103LeuVal: 6.103 ± 0.029	1.076LeuTrp: 1.076 ± 0.012	2.389LeuTyr: 2.389 ± 0.017	0.0LeuXaa: 0.0 ± 0.0
Met	1.445MetAla: 1.445 ± 0.013	0.419MetCys: 0.419 ± 0.006	1.275MetAsp: 1.275 ± 0.012	1.389MetGlu: 1.389 ± 0.013	0.752MetPhe: 0.752 ± 0.01	1.032MetGly: 1.032 ± 0.012	0.564MetHis: 0.564 ± 0.008	0.887MetIle: 0.887 ± 0.011	1.018MetLys: 1.018 ± 0.011	1.969MetLeu: 1.969 ± 0.015	0.516MetMet: 0.516 ± 0.013	0.994MetAsn: 0.994 ± 0.011	1.063MetPro: 1.063 ± 0.011	0.875MetGln: 0.875 ± 0.009	1.241MetArg: 1.241 ± 0.012	1.686MetSer: 1.686 ± 0.012	1.213MetThr: 1.213 ± 0.01	1.224MetVal: 1.224 ± 0.011	0.203MetTrp: 0.203 ± 0.004	0.506MetTyr: 0.506 ± 0.007	0.0MetXaa: 0.0 ± 0.0
Asn	2.787AsnAla: 2.787 ± 0.017	0.85AsnCys: 0.85 ± 0.01	1.889AsnAsp: 1.889 ± 0.013	2.466AsnGlu: 2.466 ± 0.015	1.536AsnPhe: 1.536 ± 0.013	2.692AsnGly: 2.692 ± 0.022	1.053AsnHis: 1.053 ± 0.011	1.88AsnIle: 1.88 ± 0.016	1.7AsnLys: 1.7 ± 0.014	4.15AsnLeu: 4.15 ± 0.025	0.878AsnMet: 0.878 ± 0.011	1.602AsnAsn: 1.602 ± 0.015	2.573AsnPro: 2.573 ± 0.018	1.87AsnGln: 1.87 ± 0.014	2.597AsnArg: 2.597 ± 0.017	3.76AsnSer: 3.76 ± 0.026	2.447AsnThr: 2.447 ± 0.016	2.611AsnVal: 2.611 ± 0.014	0.495AsnTrp: 0.495 ± 0.007	1.139AsnTyr: 1.139 ± 0.01	0.0AsnXaa: 0.0 ± 0.0
Pro	3.87ProAla: 3.87 ± 0.024	1.048ProCys: 1.048 ± 0.011	3.187ProAsp: 3.187 ± 0.02	3.516ProGlu: 3.516 ± 0.024	1.989ProPhe: 1.989 ± 0.014	3.547ProGly: 3.547 ± 0.055	1.518ProHis: 1.518 ± 0.013	2.705ProIle: 2.705 ± 0.018	2.574ProLys: 2.574 ± 0.017	5.021ProLeu: 5.021 ± 0.028	1.086ProMet: 1.086 ± 0.011	2.76ProAsn: 2.76 ± 0.019	4.696ProPro: 4.696 ± 0.045	2.342ProGln: 2.342 ± 0.019	3.187ProArg: 3.187 ± 0.024	6.279ProSer: 6.279 ± 0.043	4.461ProThr: 4.461 ± 0.028	4.426ProVal: 4.426 ± 0.032	0.591ProTrp: 0.591 ± 0.009	1.444ProTyr: 1.444 ± 0.012	0.0ProXaa: 0.0 ± 0.0
Gln	2.925GlnAla: 2.925 ± 0.02	0.884GlnCys: 0.884 ± 0.013	1.667GlnAsp: 1.667 ± 0.012	2.233GlnGlu: 2.233 ± 0.017	1.646GlnPhe: 1.646 ± 0.011	1.646GlnGly: 1.646 ± 0.017	1.298GlnHis: 1.298 ± 0.013	1.976GlnIle: 1.976 ± 0.015	1.959GlnLys: 1.959 ± 0.015	5.391GlnLeu: 5.391 ± 0.03	1.025GlnMet: 1.025 ± 0.01	1.806GlnAsn: 1.806 ± 0.013	2.983GlnPro: 2.983 ± 0.027	2.671GlnGln: 2.671 ± 0.034	2.911GlnArg: 2.911 ± 0.02	3.935GlnSer: 3.935 ± 0.023	2.97GlnThr: 2.97 ± 0.024	2.401GlnVal: 2.401 ± 0.016	0.537GlnTrp: 0.537 ± 0.009	1.083GlnTyr: 1.083 ± 0.01	0.0GlnXaa: 0.0 ± 0.0
Arg	3.825ArgAla: 3.825 ± 0.017	1.437ArgCys: 1.437 ± 0.018	2.803ArgAsp: 2.803 ± 0.017	3.428ArgGlu: 3.428 ± 0.02	2.552ArgPhe: 2.552 ± 0.017	3.024ArgGly: 3.024 ± 0.025	1.833ArgHis: 1.833 ± 0.015	3.325ArgIle: 3.325 ± 0.022	3.227ArgLys: 3.227 ± 0.021	7.237ArgLeu: 7.237 ± 0.033	1.443ArgMet: 1.443 ± 0.012	2.525ArgAsn: 2.525 ± 0.017	3.627ArgPro: 3.627 ± 0.024	2.935ArgGln: 2.935 ± 0.02	5.314ArgArg: 5.314 ± 0.03	5.783ArgSer: 5.783 ± 0.031	3.87ArgThr: 3.87 ± 0.019	3.633ArgVal: 3.633 ± 0.024	0.802ArgTrp: 0.802 ± 0.01	1.764ArgTyr: 1.764 ± 0.015	0.0ArgXaa: 0.0 ± 0.0
Ser	6.546SerAla: 6.546 ± 0.032	1.777SerCys: 1.777 ± 0.015	5.032SerAsp: 5.032 ± 0.026	5.293SerGlu: 5.293 ± 0.031	3.108SerPhe: 3.108 ± 0.018	5.97SerGly: 5.97 ± 0.032	2.446SerHis: 2.446 ± 0.018	3.915SerIle: 3.915 ± 0.021	3.936SerLys: 3.936 ± 0.022	8.358SerLeu: 8.358 ± 0.033	1.765SerMet: 1.765 ± 0.014	3.85SerAsn: 3.85 ± 0.023	6.005SerPro: 6.005 ± 0.039	3.712SerGln: 3.712 ± 0.02	5.418SerArg: 5.418 ± 0.034	10.984SerSer: 10.984 ± 0.075	6.663SerThr: 6.663 ± 0.037	6.362SerVal: 6.362 ± 0.029	0.959SerTrp: 0.959 ± 0.011	2.06SerTyr: 2.06 ± 0.016	0.0SerXaa: 0.0 ± 0.0
Thr	4.546ThrAla: 4.546 ± 0.021	1.277ThrCys: 1.277 ± 0.013	3.554ThrAsp: 3.554 ± 0.02	3.945ThrGlu: 3.945 ± 0.024	2.141ThrPhe: 2.141 ± 0.015	4.012ThrGly: 4.012 ± 0.022	1.577ThrHis: 1.577 ± 0.012	2.725ThrIle: 2.725 ± 0.018	2.757ThrLys: 2.757 ± 0.017	5.434ThrLeu: 5.434 ± 0.026	1.247ThrMet: 1.247 ± 0.012	2.837ThrAsn: 2.837 ± 0.017	3.989ThrPro: 3.989 ± 0.028	2.595ThrGln: 2.595 ± 0.022	3.426ThrArg: 3.426 ± 0.019	6.366ThrSer: 6.366 ± 0.038	4.64ThrThr: 4.64 ± 0.029	4.445ThrVal: 4.445 ± 0.025	0.677ThrTrp: 0.677 ± 0.009	1.606ThrTyr: 1.606 ± 0.013	0.0ThrXaa: 0.0 ± 0.0
Val	4.482ValAla: 4.482 ± 0.026	1.537ValCys: 1.537 ± 0.013	3.803ValAsp: 3.803 ± 0.023	3.764ValGlu: 3.764 ± 0.029	2.409ValPhe: 2.409 ± 0.018	3.488ValGly: 3.488 ± 0.022	1.846ValHis: 1.846 ± 0.015	2.998ValIle: 2.998 ± 0.02	2.697ValLys: 2.697 ± 0.02	5.844ValLeu: 5.844 ± 0.028	1.171ValMet: 1.171 ± 0.012	2.778ValAsn: 2.778 ± 0.017	3.793ValPro: 3.793 ± 0.027	2.72ValGln: 2.72 ± 0.023	3.929ValArg: 3.929 ± 0.02	5.638ValSer: 5.638 ± 0.033	4.102ValThr: 4.102 ± 0.03	4.204ValVal: 4.204 ± 0.023	0.728ValTrp: 0.728 ± 0.009	1.876ValTyr: 1.876 ± 0.016	0.0ValXaa: 0.0 ± 0.0
Trp	0.603TrpAla: 0.603 ± 0.009	0.261TrpCys: 0.261 ± 0.005	0.611TrpAsp: 0.611 ± 0.008	0.541TrpGlu: 0.541 ± 0.008	0.518TrpPhe: 0.518 ± 0.008	0.451TrpGly: 0.451 ± 0.008	0.312TrpHis: 0.312 ± 0.006	0.704TrpIle: 0.704 ± 0.008	0.596TrpLys: 0.596 ± 0.008	1.275TrpLeu: 1.275 ± 0.013	0.292TrpMet: 0.292 ± 0.005	0.591TrpAsn: 0.591 ± 0.007	0.574TrpPro: 0.574 ± 0.008	0.446TrpGln: 0.446 ± 0.007	0.794TrpArg: 0.794 ± 0.009	1.065TrpSer: 1.065 ± 0.009	0.725TrpThr: 0.725 ± 0.01	0.563TrpVal: 0.563 ± 0.009	0.171TrpTrp: 0.171 ± 0.005	0.329TrpTyr: 0.329 ± 0.006	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.773TyrAla: 1.773 ± 0.016	0.623TyrCys: 0.623 ± 0.009	1.357TyrAsp: 1.357 ± 0.014	1.48TyrGlu: 1.48 ± 0.014	1.192TyrPhe: 1.192 ± 0.013	1.648TyrGly: 1.648 ± 0.013	0.789TyrHis: 0.789 ± 0.01	1.187TyrIle: 1.187 ± 0.012	1.041TyrLys: 1.041 ± 0.01	2.78TyrLeu: 2.78 ± 0.021	0.573TyrMet: 0.573 ± 0.007	0.994TyrAsn: 0.994 ± 0.011	1.53TyrPro: 1.53 ± 0.013	1.12TyrGln: 1.12 ± 0.01	1.87TyrArg: 1.87 ± 0.017	2.212TyrSer: 2.212 ± 0.016	1.544TyrThr: 1.544 ± 0.012	1.67TyrVal: 1.67 ± 0.014	0.355TyrTrp: 0.355 ± 0.006	0.862TyrTyr: 0.862 ± 0.011	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 18330 proteins (10710057 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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