Amino acid dipepetide frequency for uncultured phage_MedDCM-OCT-S30-C28

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
0.0AlaAla: 0.0 ± 0.0
0.341AlaCys: 0.341 ± 0.155
4.092AlaAsp: 4.092 ± 0.643
4.263AlaGlu: 4.263 ± 0.758
2.558AlaPhe: 2.558 ± 0.476
4.263AlaGly: 4.263 ± 0.623
0.426AlaHis: 0.426 ± 0.172
5.542AlaIle: 5.542 ± 0.714
7.418AlaLys: 7.418 ± 1.049
5.286AlaLeu: 5.286 ± 0.843
2.046AlaMet: 2.046 ± 0.427
5.542AlaAsn: 5.542 ± 0.976
1.705AlaPro: 1.705 ± 0.396
2.728AlaGln: 2.728 ± 0.389
3.069AlaArg: 3.069 ± 0.696
5.286AlaSer: 5.286 ± 1.032
4.689AlaThr: 4.689 ± 0.714
4.178AlaVal: 4.178 ± 0.431
0.341AlaTrp: 0.341 ± 0.165
1.79AlaTyr: 1.79 ± 0.567
0.0AlaXaa: 0.0 ± 0.0
Cys
0.426CysAla: 0.426 ± 0.18
0.171CysCys: 0.171 ± 0.141
0.0CysAsp: 0.0 ± 0.0
0.682CysGlu: 0.682 ± 0.224
0.256CysPhe: 0.256 ± 0.2
0.853CysGly: 0.853 ± 0.367
0.171CysHis: 0.171 ± 0.106
0.767CysIle: 0.767 ± 0.235
1.108CysLys: 1.108 ± 0.395
0.767CysLeu: 0.767 ± 0.245
0.171CysMet: 0.171 ± 0.114
0.256CysAsn: 0.256 ± 0.16
0.426CysPro: 0.426 ± 0.185
0.256CysGln: 0.256 ± 0.158
0.426CysArg: 0.426 ± 0.195
0.767CysSer: 0.767 ± 0.266
0.341CysThr: 0.341 ± 0.137
0.597CysVal: 0.597 ± 0.268
0.171CysTrp: 0.171 ± 0.128
0.171CysTyr: 0.171 ± 0.111
0.0CysXaa: 0.0 ± 0.0
Asp
4.263AspAla: 4.263 ± 0.542
0.597AspCys: 0.597 ± 0.193
3.496AspAsp: 3.496 ± 0.423
5.03AspGlu: 5.03 ± 0.94
3.496AspPhe: 3.496 ± 0.626
4.178AspGly: 4.178 ± 0.46
0.597AspHis: 0.597 ± 0.285
4.178AspIle: 4.178 ± 0.567
6.48AspLys: 6.48 ± 0.755
5.116AspLeu: 5.116 ± 0.629
1.023AspMet: 1.023 ± 0.285
3.069AspAsn: 3.069 ± 0.573
2.302AspPro: 2.302 ± 0.468
1.279AspGln: 1.279 ± 0.382
2.387AspArg: 2.387 ± 0.377
2.558AspSer: 2.558 ± 0.411
3.41AspThr: 3.41 ± 0.685
3.24AspVal: 3.24 ± 0.488
0.767AspTrp: 0.767 ± 0.341
2.643AspTyr: 2.643 ± 0.495
0.0AspXaa: 0.0 ± 0.0
Glu
6.053GluAla: 6.053 ± 0.811
0.341GluCys: 0.341 ± 0.171
4.433GluAsp: 4.433 ± 0.774
4.348GluGlu: 4.348 ± 0.674
3.751GluPhe: 3.751 ± 0.786
2.814GluGly: 2.814 ± 0.681
0.767GluHis: 0.767 ± 0.252
4.604GluIle: 4.604 ± 0.542
6.139GluLys: 6.139 ± 0.812
5.712GluLeu: 5.712 ± 0.603
1.705GluMet: 1.705 ± 0.291
2.814GluAsn: 2.814 ± 0.514
0.938GluPro: 0.938 ± 0.36
3.496GluGln: 3.496 ± 0.64
2.643GluArg: 2.643 ± 0.494
2.387GluSer: 2.387 ± 0.426
4.519GluThr: 4.519 ± 0.719
3.751GluVal: 3.751 ± 0.527
0.512GluTrp: 0.512 ± 0.231
2.558GluTyr: 2.558 ± 0.509
0.0GluXaa: 0.0 ± 0.0
Phe
2.046PheAla: 2.046 ± 0.441
0.341PheCys: 0.341 ± 0.168
3.922PheAsp: 3.922 ± 0.8
1.705PheGlu: 1.705 ± 0.396
1.364PhePhe: 1.364 ± 0.436
3.41PheGly: 3.41 ± 0.7
0.512PheHis: 0.512 ± 0.197
3.069PheIle: 3.069 ± 0.595
3.496PheLys: 3.496 ± 0.552
3.325PheLeu: 3.325 ± 0.445
0.682PheMet: 0.682 ± 0.271
3.24PheAsn: 3.24 ± 0.443
1.449PhePro: 1.449 ± 0.367
1.705PheGln: 1.705 ± 0.362
2.046PheArg: 2.046 ± 0.471
3.24PheSer: 3.24 ± 0.517
3.155PheThr: 3.155 ± 0.464
1.79PheVal: 1.79 ± 0.426
0.341PheTrp: 0.341 ± 0.181
1.705PheTyr: 1.705 ± 0.304
0.0PheXaa: 0.0 ± 0.0
Gly
4.092GlyAla: 4.092 ± 0.555
0.341GlyCys: 0.341 ± 0.198
4.178GlyAsp: 4.178 ± 0.506
3.837GlyGlu: 3.837 ± 0.621
2.984GlyPhe: 2.984 ± 0.483
3.581GlyGly: 3.581 ± 0.665
0.853GlyHis: 0.853 ± 0.277
3.751GlyIle: 3.751 ± 0.638
4.604GlyLys: 4.604 ± 0.538
4.433GlyLeu: 4.433 ± 0.547
1.535GlyMet: 1.535 ± 0.406
3.581GlyAsn: 3.581 ± 0.494
0.0GlyPro: 0.0 ± 0.0
2.899GlyGln: 2.899 ± 0.594
2.643GlyArg: 2.643 ± 0.469
5.457GlySer: 5.457 ± 0.768
4.945GlyThr: 4.945 ± 1.122
4.092GlyVal: 4.092 ± 0.659
0.512GlyTrp: 0.512 ± 0.211
2.131GlyTyr: 2.131 ± 0.399
0.0GlyXaa: 0.0 ± 0.0
His
0.256HisAla: 0.256 ± 0.15
0.426HisCys: 0.426 ± 0.181
0.597HisAsp: 0.597 ± 0.216
0.682HisGlu: 0.682 ± 0.225
0.341HisPhe: 0.341 ± 0.173
0.682HisGly: 0.682 ± 0.286
0.682HisHis: 0.682 ± 0.265
1.108HisIle: 1.108 ± 0.303
1.279HisLys: 1.279 ± 0.396
2.302HisLeu: 2.302 ± 0.402
0.426HisMet: 0.426 ± 0.204
1.108HisAsn: 1.108 ± 0.385
0.171HisPro: 0.171 ± 0.128
0.597HisGln: 0.597 ± 0.24
0.853HisArg: 0.853 ± 0.272
1.364HisSer: 1.364 ± 0.405
1.62HisThr: 1.62 ± 0.407
0.426HisVal: 0.426 ± 0.177
0.341HisTrp: 0.341 ± 0.148
1.023HisTyr: 1.023 ± 0.339
0.0HisXaa: 0.0 ± 0.0
Ile
4.774IleAla: 4.774 ± 0.655
1.194IleCys: 1.194 ± 0.308
4.433IleAsp: 4.433 ± 0.513
4.519IleGlu: 4.519 ± 0.726
1.449IlePhe: 1.449 ± 0.356
4.007IleGly: 4.007 ± 0.546
1.449IleHis: 1.449 ± 0.461
4.263IleIle: 4.263 ± 0.589
5.798IleLys: 5.798 ± 0.64
4.604IleLeu: 4.604 ± 0.653
1.364IleMet: 1.364 ± 0.394
4.092IleAsn: 4.092 ± 0.607
2.558IlePro: 2.558 ± 0.419
2.728IleGln: 2.728 ± 0.383
2.473IleArg: 2.473 ± 0.454
5.542IleSer: 5.542 ± 0.559
4.263IleThr: 4.263 ± 0.73
4.519IleVal: 4.519 ± 0.539
0.682IleTrp: 0.682 ± 0.181
1.961IleTyr: 1.961 ± 0.399
0.0IleXaa: 0.0 ± 0.0
Lys
5.798LysAla: 5.798 ± 0.85
0.426LysCys: 0.426 ± 0.208
4.689LysAsp: 4.689 ± 0.692
7.929LysGlu: 7.929 ± 1.155
4.689LysPhe: 4.689 ± 0.571
4.263LysGly: 4.263 ± 0.553
1.535LysHis: 1.535 ± 0.5
6.48LysIle: 6.48 ± 0.723
8.441LysLys: 8.441 ± 1.087
8.441LysLeu: 8.441 ± 0.766
2.473LysMet: 2.473 ± 0.541
4.433LysAsn: 4.433 ± 0.49
2.728LysPro: 2.728 ± 0.506
3.069LysGln: 3.069 ± 0.525
3.496LysArg: 3.496 ± 0.554
5.542LysSer: 5.542 ± 0.688
5.627LysThr: 5.627 ± 0.701
5.627LysVal: 5.627 ± 0.538
0.682LysTrp: 0.682 ± 0.244
3.496LysTyr: 3.496 ± 0.55
0.0LysXaa: 0.0 ± 0.0
Leu
5.968LeuAla: 5.968 ± 0.701
0.426LeuCys: 0.426 ± 0.21
4.86LeuAsp: 4.86 ± 0.554
5.286LeuGlu: 5.286 ± 0.984
2.899LeuPhe: 2.899 ± 0.346
4.604LeuGly: 4.604 ± 0.591
1.449LeuHis: 1.449 ± 0.43
4.433LeuIle: 4.433 ± 0.609
6.821LeuLys: 6.821 ± 0.825
5.371LeuLeu: 5.371 ± 0.734
1.876LeuMet: 1.876 ± 0.391
6.224LeuAsn: 6.224 ± 0.783
4.007LeuPro: 4.007 ± 0.492
3.24LeuGln: 3.24 ± 0.548
4.263LeuArg: 4.263 ± 0.645
5.542LeuSer: 5.542 ± 0.727
5.03LeuThr: 5.03 ± 0.608
4.689LeuVal: 4.689 ± 0.522
0.682LeuTrp: 0.682 ± 0.219
1.79LeuTyr: 1.79 ± 0.361
0.0LeuXaa: 0.0 ± 0.0
Met
1.364MetAla: 1.364 ± 0.353
0.512MetCys: 0.512 ± 0.215
0.597MetAsp: 0.597 ± 0.223
0.853MetGlu: 0.853 ± 0.303
0.597MetPhe: 0.597 ± 0.184
1.535MetGly: 1.535 ± 0.335
0.256MetHis: 0.256 ± 0.146
1.449MetIle: 1.449 ± 0.399
2.387MetLys: 2.387 ± 0.491
1.364MetLeu: 1.364 ± 0.419
0.512MetMet: 0.512 ± 0.251
1.535MetAsn: 1.535 ± 0.373
0.512MetPro: 0.512 ± 0.205
0.682MetGln: 0.682 ± 0.259
0.597MetArg: 0.597 ± 0.207
2.728MetSer: 2.728 ± 0.521
1.62MetThr: 1.62 ± 0.335
1.535MetVal: 1.535 ± 0.365
0.171MetTrp: 0.171 ± 0.116
0.341MetTyr: 0.341 ± 0.148
0.0MetXaa: 0.0 ± 0.0
Asn
4.774AsnAla: 4.774 ± 0.739
0.341AsnCys: 0.341 ± 0.165
3.24AsnAsp: 3.24 ± 0.489
3.837AsnGlu: 3.837 ± 0.527
2.814AsnPhe: 2.814 ± 0.445
4.348AsnGly: 4.348 ± 0.568
1.023AsnHis: 1.023 ± 0.261
4.263AsnIle: 4.263 ± 0.609
5.457AsnLys: 5.457 ± 0.623
5.542AsnLeu: 5.542 ± 0.582
1.449AsnMet: 1.449 ± 0.263
3.837AsnAsn: 3.837 ± 0.695
3.24AsnPro: 3.24 ± 0.606
2.387AsnGln: 2.387 ± 0.424
2.387AsnArg: 2.387 ± 0.457
4.263AsnSer: 4.263 ± 0.578
4.007AsnThr: 4.007 ± 0.749
4.263AsnVal: 4.263 ± 0.565
0.341AsnTrp: 0.341 ± 0.162
2.131AsnTyr: 2.131 ± 0.403
0.0AsnXaa: 0.0 ± 0.0
Pro
1.79ProAla: 1.79 ± 0.456
0.341ProCys: 0.341 ± 0.174
1.961ProAsp: 1.961 ± 0.332
3.069ProGlu: 3.069 ± 0.609
1.62ProPhe: 1.62 ± 0.387
0.0ProGly: 0.0 ± 0.0
0.682ProHis: 0.682 ± 0.199
2.302ProIle: 2.302 ± 0.42
2.643ProLys: 2.643 ± 0.494
2.046ProLeu: 2.046 ± 0.4
0.767ProMet: 0.767 ± 0.301
2.728ProAsn: 2.728 ± 0.505
1.108ProPro: 1.108 ± 0.408
1.108ProGln: 1.108 ± 0.261
1.449ProArg: 1.449 ± 0.299
2.387ProSer: 2.387 ± 0.424
2.302ProThr: 2.302 ± 0.476
2.473ProVal: 2.473 ± 0.536
0.0ProTrp: 0.0 ± 0.0
1.364ProTyr: 1.364 ± 0.251
0.0ProXaa: 0.0 ± 0.0
Gln
3.41GlnAla: 3.41 ± 0.591
0.426GlnCys: 0.426 ± 0.198
1.79GlnAsp: 1.79 ± 0.487
2.728GlnGlu: 2.728 ± 0.524
2.643GlnPhe: 2.643 ± 0.52
2.558GlnGly: 2.558 ± 0.428
0.767GlnHis: 0.767 ± 0.272
2.473GlnIle: 2.473 ± 0.399
3.666GlnLys: 3.666 ± 0.651
2.814GlnLeu: 2.814 ± 0.428
0.682GlnMet: 0.682 ± 0.252
2.728GlnAsn: 2.728 ± 0.512
1.108GlnPro: 1.108 ± 0.265
2.558GlnGln: 2.558 ± 0.619
1.364GlnArg: 1.364 ± 0.285
3.069GlnSer: 3.069 ± 0.519
2.984GlnThr: 2.984 ± 0.464
2.217GlnVal: 2.217 ± 0.5
0.256GlnTrp: 0.256 ± 0.154
1.876GlnTyr: 1.876 ± 0.336
0.0GlnXaa: 0.0 ± 0.0
Arg
2.217ArgAla: 2.217 ± 0.518
0.256ArgCys: 0.256 ± 0.146
3.325ArgAsp: 3.325 ± 0.58
2.046ArgGlu: 2.046 ± 0.465
1.62ArgPhe: 1.62 ± 0.362
2.387ArgGly: 2.387 ± 0.489
0.426ArgHis: 0.426 ± 0.211
2.643ArgIle: 2.643 ± 0.489
4.263ArgLys: 4.263 ± 0.622
3.837ArgLeu: 3.837 ± 0.548
0.597ArgMet: 0.597 ± 0.244
2.643ArgAsn: 2.643 ± 0.432
1.62ArgPro: 1.62 ± 0.345
2.131ArgGln: 2.131 ± 0.474
2.302ArgArg: 2.302 ± 0.491
2.387ArgSer: 2.387 ± 0.382
2.217ArgThr: 2.217 ± 0.547
2.473ArgVal: 2.473 ± 0.413
0.512ArgTrp: 0.512 ± 0.215
1.876ArgTyr: 1.876 ± 0.407
0.0ArgXaa: 0.0 ± 0.0
Ser
5.457SerAla: 5.457 ± 1.121
0.426SerCys: 0.426 ± 0.165
4.945SerAsp: 4.945 ± 0.591
3.41SerGlu: 3.41 ± 0.555
2.984SerPhe: 2.984 ± 0.62
5.116SerGly: 5.116 ± 0.811
1.364SerHis: 1.364 ± 0.445
4.86SerIle: 4.86 ± 0.591
4.774SerLys: 4.774 ± 0.495
4.86SerLeu: 4.86 ± 0.537
0.853SerMet: 0.853 ± 0.237
4.348SerAsn: 4.348 ± 0.781
2.387SerPro: 2.387 ± 0.416
3.41SerGln: 3.41 ± 0.551
3.496SerArg: 3.496 ± 0.511
7.418SerSer: 7.418 ± 1.267
6.053SerThr: 6.053 ± 1.187
3.325SerVal: 3.325 ± 0.512
0.597SerTrp: 0.597 ± 0.213
2.302SerTyr: 2.302 ± 0.45
0.0SerXaa: 0.0 ± 0.0
Thr
4.86ThrAla: 4.86 ± 0.655
0.512ThrCys: 0.512 ± 0.248
3.24ThrAsp: 3.24 ± 0.453
3.24ThrGlu: 3.24 ± 0.531
2.643ThrPhe: 2.643 ± 0.46
5.286ThrGly: 5.286 ± 0.736
1.876ThrHis: 1.876 ± 0.395
4.178ThrIle: 4.178 ± 1.018
5.116ThrLys: 5.116 ± 0.727
5.201ThrLeu: 5.201 ± 0.571
0.682ThrMet: 0.682 ± 0.254
4.86ThrAsn: 4.86 ± 0.712
2.558ThrPro: 2.558 ± 0.402
3.24ThrGln: 3.24 ± 0.5
1.79ThrArg: 1.79 ± 0.337
4.604ThrSer: 4.604 ± 1.044
4.945ThrThr: 4.945 ± 0.954
4.348ThrVal: 4.348 ± 0.945
1.194ThrTrp: 1.194 ± 0.274
2.899ThrTyr: 2.899 ± 0.559
0.0ThrXaa: 0.0 ± 0.0
Val
5.201ValAla: 5.201 ± 0.856
0.597ValCys: 0.597 ± 0.185
3.581ValAsp: 3.581 ± 0.685
4.178ValGlu: 4.178 ± 0.53
2.899ValPhe: 2.899 ± 0.572
3.496ValGly: 3.496 ± 0.385
0.512ValHis: 0.512 ± 0.19
3.922ValIle: 3.922 ± 0.624
5.201ValLys: 5.201 ± 0.564
4.007ValLeu: 4.007 ± 0.593
1.62ValMet: 1.62 ± 0.293
3.751ValAsn: 3.751 ± 0.646
1.62ValPro: 1.62 ± 0.418
2.473ValGln: 2.473 ± 0.425
2.302ValArg: 2.302 ± 0.433
4.689ValSer: 4.689 ± 0.78
2.984ValThr: 2.984 ± 0.496
3.837ValVal: 3.837 ± 0.622
0.682ValTrp: 0.682 ± 0.215
2.131ValTyr: 2.131 ± 0.428
0.0ValXaa: 0.0 ± 0.0
Trp
0.512TrpAla: 0.512 ± 0.177
0.341TrpCys: 0.341 ± 0.185
0.426TrpAsp: 0.426 ± 0.242
0.341TrpGlu: 0.341 ± 0.172
0.256TrpPhe: 0.256 ± 0.131
0.767TrpGly: 0.767 ± 0.275
0.256TrpHis: 0.256 ± 0.138
0.597TrpIle: 0.597 ± 0.241
0.938TrpLys: 0.938 ± 0.295
1.023TrpLeu: 1.023 ± 0.311
0.0TrpMet: 0.0 ± 0.0
0.682TrpAsn: 0.682 ± 0.28
0.0TrpPro: 0.0 ± 0.0
0.256TrpGln: 0.256 ± 0.17
0.341TrpArg: 0.341 ± 0.205
0.767TrpSer: 0.767 ± 0.254
0.853TrpThr: 0.853 ± 0.363
0.341TrpVal: 0.341 ± 0.241
0.171TrpTrp: 0.171 ± 0.108
0.426TrpTyr: 0.426 ± 0.192
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.302TyrAla: 2.302 ± 0.423
0.426TyrCys: 0.426 ± 0.183
2.302TyrAsp: 2.302 ± 0.383
2.302TyrGlu: 2.302 ± 0.48
0.767TyrPhe: 0.767 ± 0.242
2.302TyrGly: 2.302 ± 0.42
0.682TyrHis: 0.682 ± 0.248
1.79TyrIle: 1.79 ± 0.432
3.837TyrLys: 3.837 ± 0.7
3.41TyrLeu: 3.41 ± 0.614
0.597TyrMet: 0.597 ± 0.26
2.473TyrAsn: 2.473 ± 0.359
1.705TyrPro: 1.705 ± 0.452
1.876TyrGln: 1.876 ± 0.325
1.449TyrArg: 1.449 ± 0.396
2.387TyrSer: 2.387 ± 0.496
1.705TyrThr: 1.705 ± 0.357
1.961TyrVal: 1.961 ± 0.394
0.341TyrTrp: 0.341 ± 0.187
1.62TyrTyr: 1.62 ± 0.365
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 51 proteins (11730 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski