Amino acid dipepetide frequency for Aneurinibacillus migulanus (Bacillus migulanus)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.684AlaAla: 6.684 ± 0.09	0.777AlaCys: 0.777 ± 0.024	3.567AlaAsp: 3.567 ± 0.052	5.375AlaGlu: 5.375 ± 0.072	3.428AlaPhe: 3.428 ± 0.05	5.917AlaGly: 5.917 ± 0.078	1.471AlaHis: 1.471 ± 0.031	5.795AlaIle: 5.795 ± 0.074	4.479AlaLys: 4.479 ± 0.056	8.081AlaLeu: 8.081 ± 0.085	2.235AlaMet: 2.235 ± 0.038	2.612AlaAsn: 2.612 ± 0.042	2.468AlaPro: 2.468 ± 0.04	2.839AlaGln: 2.839 ± 0.045	3.798AlaArg: 3.798 ± 0.048	4.59AlaSer: 4.59 ± 0.055	3.778AlaThr: 3.778 ± 0.049	5.791AlaVal: 5.791 ± 0.065	0.753AlaTrp: 0.753 ± 0.026	2.749AlaTyr: 2.749 ± 0.039	0.0AlaXaa: 0.0 ± 0.0
Cys	0.575CysAla: 0.575 ± 0.02	0.122CysCys: 0.122 ± 0.008	0.439CysAsp: 0.439 ± 0.015	0.518CysGlu: 0.518 ± 0.019	0.402CysPhe: 0.402 ± 0.016	0.793CysGly: 0.793 ± 0.023	0.215CysHis: 0.215 ± 0.013	0.658CysIle: 0.658 ± 0.019	0.447CysLys: 0.447 ± 0.019	0.827CysLeu: 0.827 ± 0.026	0.253CysMet: 0.253 ± 0.011	0.314CysAsn: 0.314 ± 0.014	0.4CysPro: 0.4 ± 0.017	0.283CysGln: 0.283 ± 0.016	0.449CysArg: 0.449 ± 0.019	0.522CysSer: 0.522 ± 0.019	0.49CysThr: 0.49 ± 0.019	0.521CysVal: 0.521 ± 0.019	0.104CysTrp: 0.104 ± 0.008	0.289CysTyr: 0.289 ± 0.014	0.001CysXaa: 0.001 ± 0.001
Asp	3.445AspAla: 3.445 ± 0.049	0.425AspCys: 0.425 ± 0.017	2.162AspAsp: 2.162 ± 0.046	4.105AspGlu: 4.105 ± 0.063	2.13AspPhe: 2.13 ± 0.032	3.275AspGly: 3.275 ± 0.055	0.84AspHis: 0.84 ± 0.022	4.15AspIle: 4.15 ± 0.055	3.061AspLys: 3.061 ± 0.041	4.1AspLeu: 4.1 ± 0.059	1.554AspMet: 1.554 ± 0.029	1.715AspAsn: 1.715 ± 0.031	1.838AspPro: 1.838 ± 0.034	1.384AspGln: 1.384 ± 0.03	2.2AspArg: 2.2 ± 0.042	2.31AspSer: 2.31 ± 0.037	2.583AspThr: 2.583 ± 0.041	3.787AspVal: 3.787 ± 0.053	0.62AspTrp: 0.62 ± 0.02	1.854AspTyr: 1.854 ± 0.035	0.001AspXaa: 0.001 ± 0.001
Glu	6.099GluAla: 6.099 ± 0.067	0.489GluCys: 0.489 ± 0.017	3.374GluAsp: 3.374 ± 0.054	6.927GluGlu: 6.927 ± 0.085	2.333GluPhe: 2.333 ± 0.039	4.491GluGly: 4.491 ± 0.061	1.582GluHis: 1.582 ± 0.034	5.074GluIle: 5.074 ± 0.062	6.157GluLys: 6.157 ± 0.073	6.826GluLeu: 6.826 ± 0.077	2.412GluMet: 2.412 ± 0.039	3.097GluAsn: 3.097 ± 0.043	1.986GluPro: 1.986 ± 0.041	3.866GluGln: 3.866 ± 0.053	4.465GluArg: 4.465 ± 0.061	3.356GluSer: 3.356 ± 0.048	3.619GluThr: 3.619 ± 0.046	4.934GluVal: 4.934 ± 0.053	0.946GluTrp: 0.946 ± 0.024	2.355GluTyr: 2.355 ± 0.039	0.001GluXaa: 0.001 ± 0.001
Phe	3.248PheAla: 3.248 ± 0.043	0.43PheCys: 0.43 ± 0.018	2.145PheAsp: 2.145 ± 0.039	2.509PheGlu: 2.509 ± 0.044	2.224PhePhe: 2.224 ± 0.05	3.183PheGly: 3.183 ± 0.05	0.905PheHis: 0.905 ± 0.025	3.481PheIle: 3.481 ± 0.057	1.806PheLys: 1.806 ± 0.033	4.55PheLeu: 4.55 ± 0.067	1.143PheMet: 1.143 ± 0.025	1.493PheAsn: 1.493 ± 0.031	1.688PhePro: 1.688 ± 0.034	1.331PheGln: 1.331 ± 0.029	1.724PheArg: 1.724 ± 0.035	3.022PheSer: 3.022 ± 0.048	2.609PheThr: 2.609 ± 0.043	3.113PheVal: 3.113 ± 0.055	0.471PheTrp: 0.471 ± 0.02	1.572PheTyr: 1.572 ± 0.034	0.0PheXaa: 0.0 ± 0.0
Gly	5.389GlyAla: 5.389 ± 0.075	0.739GlyCys: 0.739 ± 0.024	3.04GlyAsp: 3.04 ± 0.046	4.726GlyGlu: 4.726 ± 0.062	3.244GlyPhe: 3.244 ± 0.054	4.936GlyGly: 4.936 ± 0.085	1.405GlyHis: 1.405 ± 0.032	5.972GlyIle: 5.972 ± 0.07	4.927GlyLys: 4.927 ± 0.059	6.535GlyLeu: 6.535 ± 0.078	2.382GlyMet: 2.382 ± 0.04	2.514GlyAsn: 2.514 ± 0.044	1.846GlyPro: 1.846 ± 0.039	2.408GlyGln: 2.408 ± 0.04	3.38GlyArg: 3.38 ± 0.055	3.738GlySer: 3.738 ± 0.049	4.256GlyThr: 4.256 ± 0.064	5.189GlyVal: 5.189 ± 0.062	0.954GlyTrp: 0.954 ± 0.025	2.858GlyTyr: 2.858 ± 0.045	0.001GlyXaa: 0.001 ± 0.001
His	1.507HisAla: 1.507 ± 0.031	0.2HisCys: 0.2 ± 0.011	0.978HisAsp: 0.978 ± 0.026	1.412HisGlu: 1.412 ± 0.03	0.97HisPhe: 0.97 ± 0.022	1.452HisGly: 1.452 ± 0.03	0.61HisHis: 0.61 ± 0.023	1.668HisIle: 1.668 ± 0.035	1.077HisLys: 1.077 ± 0.03	2.094HisLeu: 2.094 ± 0.038	0.603HisMet: 0.603 ± 0.023	0.757HisAsn: 0.757 ± 0.02	1.295HisPro: 1.295 ± 0.031	0.749HisGln: 0.749 ± 0.022	1.047HisArg: 1.047 ± 0.025	1.177HisSer: 1.177 ± 0.028	1.164HisThr: 1.164 ± 0.029	1.506HisVal: 1.506 ± 0.03	0.253HisTrp: 0.253 ± 0.014	0.845HisTyr: 0.845 ± 0.022	0.001HisXaa: 0.001 ± 0.001
Ile	6.198IleAla: 6.198 ± 0.077	0.746IleCys: 0.746 ± 0.022	3.794IleAsp: 3.794 ± 0.049	5.427IleGlu: 5.427 ± 0.072	2.909IlePhe: 2.909 ± 0.05	5.859IleGly: 5.859 ± 0.071	1.638IleHis: 1.638 ± 0.029	5.194IleIle: 5.194 ± 0.077	3.832IleLys: 3.832 ± 0.062	6.566IleLeu: 6.566 ± 0.074	1.853IleMet: 1.853 ± 0.03	2.745IleAsn: 2.745 ± 0.05	3.395IlePro: 3.395 ± 0.043	2.751IleGln: 2.751 ± 0.049	3.659IleArg: 3.659 ± 0.054	4.608IleSer: 4.608 ± 0.062	4.253IleThr: 4.253 ± 0.057	5.587IleVal: 5.587 ± 0.063	0.725IleTrp: 0.725 ± 0.021	2.271IleTyr: 2.271 ± 0.04	0.001IleXaa: 0.001 ± 0.001
Lys	4.588LysAla: 4.588 ± 0.068	0.331LysCys: 0.331 ± 0.016	3.057LysAsp: 3.057 ± 0.049	6.079LysGlu: 6.079 ± 0.075	1.622LysPhe: 1.622 ± 0.032	4.011LysGly: 4.011 ± 0.048	1.248LysHis: 1.248 ± 0.028	3.95LysIle: 3.95 ± 0.063	5.064LysLys: 5.064 ± 0.066	5.27LysLeu: 5.27 ± 0.063	2.009LysMet: 2.009 ± 0.036	2.794LysAsn: 2.794 ± 0.047	2.312LysPro: 2.312 ± 0.039	3.099LysGln: 3.099 ± 0.053	3.389LysArg: 3.389 ± 0.048	3.036LysSer: 3.036 ± 0.05	3.242LysThr: 3.242 ± 0.041	4.306LysVal: 4.306 ± 0.057	0.689LysTrp: 0.689 ± 0.019	2.055LysTyr: 2.055 ± 0.036	0.0LysXaa: 0.0 ± 0.0
Leu	8.163LeuAla: 8.163 ± 0.089	0.893LeuCys: 0.893 ± 0.027	4.687LeuAsp: 4.687 ± 0.063	6.414LeuGlu: 6.414 ± 0.082	4.687LeuPhe: 4.687 ± 0.066	6.624LeuGly: 6.624 ± 0.075	2.293LeuHis: 2.293 ± 0.041	6.473LeuIle: 6.473 ± 0.077	5.386LeuLys: 5.386 ± 0.064	10.443LeuLeu: 10.443 ± 0.119	2.411LeuMet: 2.411 ± 0.04	3.461LeuAsn: 3.461 ± 0.048	4.318LeuPro: 4.318 ± 0.058	3.861LeuGln: 3.861 ± 0.054	4.564LeuArg: 4.564 ± 0.061	6.571LeuSer: 6.571 ± 0.069	5.546LeuThr: 5.546 ± 0.06	6.383LeuVal: 6.383 ± 0.075	0.894LeuTrp: 0.894 ± 0.028	3.356LeuTyr: 3.356 ± 0.047	0.001LeuXaa: 0.001 ± 0.001
Met	2.332MetAla: 2.332 ± 0.041	0.184MetCys: 0.184 ± 0.012	1.493MetAsp: 1.493 ± 0.03	2.24MetGlu: 2.24 ± 0.042	1.047MetPhe: 1.047 ± 0.025	1.919MetGly: 1.919 ± 0.037	0.536MetHis: 0.536 ± 0.019	1.993MetIle: 1.993 ± 0.039	2.338MetLys: 2.338 ± 0.042	2.832MetLeu: 2.832 ± 0.044	0.941MetMet: 0.941 ± 0.023	1.435MetAsn: 1.435 ± 0.03	1.152MetPro: 1.152 ± 0.033	1.106MetGln: 1.106 ± 0.027	1.438MetArg: 1.438 ± 0.026	1.785MetSer: 1.785 ± 0.035	1.521MetThr: 1.521 ± 0.029	1.926MetVal: 1.926 ± 0.03	0.233MetTrp: 0.233 ± 0.013	0.878MetTyr: 0.878 ± 0.027	0.001MetXaa: 0.001 ± 0.001
Asn	2.577AsnAla: 2.577 ± 0.041	0.316AsnCys: 0.316 ± 0.015	1.703AsnAsp: 1.703 ± 0.031	2.837AsnGlu: 2.837 ± 0.043	1.371AsnPhe: 1.371 ± 0.032	3.014AsnGly: 3.014 ± 0.052	0.888AsnHis: 0.888 ± 0.026	3.019AsnIle: 3.019 ± 0.047	2.465AsnLys: 2.465 ± 0.039	3.332AsnLeu: 3.332 ± 0.04	1.134AsnMet: 1.134 ± 0.026	1.537AsnAsn: 1.537 ± 0.038	2.054AsnPro: 2.054 ± 0.036	1.613AsnGln: 1.613 ± 0.035	2.099AsnArg: 2.099 ± 0.037	1.77AsnSer: 1.77 ± 0.036	1.966AsnThr: 1.966 ± 0.038	2.884AsnVal: 2.884 ± 0.044	0.454AsnTrp: 0.454 ± 0.016	1.243AsnTyr: 1.243 ± 0.027	0.001AsnXaa: 0.001 ± 0.001
Pro	2.68ProAla: 2.68 ± 0.041	0.256ProCys: 0.256 ± 0.015	2.284ProAsp: 2.284 ± 0.04	3.223ProGlu: 3.223 ± 0.046	1.9ProPhe: 1.9 ± 0.036	2.794ProGly: 2.794 ± 0.046	0.937ProHis: 0.937 ± 0.028	2.649ProIle: 2.649 ± 0.038	2.031ProLys: 2.031 ± 0.037	3.93ProLeu: 3.93 ± 0.051	0.912ProMet: 0.912 ± 0.027	1.497ProAsn: 1.497 ± 0.031	1.311ProPro: 1.311 ± 0.033	1.291ProGln: 1.291 ± 0.031	1.447ProArg: 1.447 ± 0.034	2.336ProSer: 2.336 ± 0.035	2.045ProThr: 2.045 ± 0.035	3.205ProVal: 3.205 ± 0.048	0.445ProTrp: 0.445 ± 0.016	1.537ProTyr: 1.537 ± 0.032	0.0ProXaa: 0.0 ± 0.0
Gln	3.416GlnAla: 3.416 ± 0.057	0.241GlnCys: 0.241 ± 0.014	1.66GlnAsp: 1.66 ± 0.035	3.197GlnGlu: 3.197 ± 0.053	1.433GlnPhe: 1.433 ± 0.031	2.51GlnGly: 2.51 ± 0.041	0.846GlnHis: 0.846 ± 0.023	2.622GlnIle: 2.622 ± 0.042	2.601GlnLys: 2.601 ± 0.051	3.749GlnLeu: 3.749 ± 0.054	1.22GlnMet: 1.22 ± 0.03	1.5GlnAsn: 1.5 ± 0.029	1.438GlnPro: 1.438 ± 0.036	1.993GlnGln: 1.993 ± 0.044	1.952GlnArg: 1.952 ± 0.033	1.974GlnSer: 1.974 ± 0.038	2.054GlnThr: 2.054 ± 0.038	2.677GlnVal: 2.677 ± 0.041	0.393GlnTrp: 0.393 ± 0.015	1.291GlnTyr: 1.291 ± 0.033	0.0GlnXaa: 0.0 ± 0.0
Arg	3.28ArgAla: 3.28 ± 0.055	0.399ArgCys: 0.399 ± 0.015	2.26ArgAsp: 2.26 ± 0.038	3.967ArgGlu: 3.967 ± 0.058	2.109ArgPhe: 2.109 ± 0.041	2.816ArgGly: 2.816 ± 0.047	1.063ArgHis: 1.063 ± 0.026	4.011ArgIle: 4.011 ± 0.055	3.535ArgLys: 3.535 ± 0.053	5.021ArgLeu: 5.021 ± 0.06	1.74ArgMet: 1.74 ± 0.038	2.005ArgAsn: 2.005 ± 0.033	1.673ArgPro: 1.673 ± 0.032	2.095ArgGln: 2.095 ± 0.035	2.789ArgArg: 2.789 ± 0.063	2.553ArgSer: 2.553 ± 0.042	2.532ArgThr: 2.532 ± 0.039	3.22ArgVal: 3.22 ± 0.048	0.599ArgTrp: 0.599 ± 0.018	1.881ArgTyr: 1.881 ± 0.033	0.003ArgXaa: 0.003 ± 0.001
Ser	4.058SerAla: 4.058 ± 0.059	0.512SerCys: 0.512 ± 0.018	2.517SerAsp: 2.517 ± 0.045	3.602SerGlu: 3.602 ± 0.049	3.034SerPhe: 3.034 ± 0.044	4.368SerGly: 4.368 ± 0.053	1.243SerHis: 1.243 ± 0.024	4.475SerIle: 4.475 ± 0.057	3.08SerLys: 3.08 ± 0.047	6.035SerLeu: 6.035 ± 0.064	1.761SerMet: 1.761 ± 0.033	2.039SerAsn: 2.039 ± 0.039	2.195SerPro: 2.195 ± 0.041	1.931SerGln: 1.931 ± 0.039	2.808SerArg: 2.808 ± 0.05	3.538SerSer: 3.538 ± 0.055	3.0SerThr: 3.0 ± 0.042	4.176SerVal: 4.176 ± 0.051	0.624SerTrp: 0.624 ± 0.02	2.115SerTyr: 2.115 ± 0.039	0.001SerXaa: 0.001 ± 0.001
Thr	4.185ThrAla: 4.185 ± 0.057	0.436ThrCys: 0.436 ± 0.018	2.5ThrAsp: 2.5 ± 0.038	3.667ThrGlu: 3.667 ± 0.049	2.535ThrPhe: 2.535 ± 0.041	4.408ThrGly: 4.408 ± 0.06	1.077ThrHis: 1.077 ± 0.027	4.084ThrIle: 4.084 ± 0.049	2.96ThrLys: 2.96 ± 0.042	5.471ThrLeu: 5.471 ± 0.055	1.417ThrMet: 1.417 ± 0.035	2.101ThrAsn: 2.101 ± 0.037	2.507ThrPro: 2.507 ± 0.038	1.66ThrGln: 1.66 ± 0.034	2.332ThrArg: 2.332 ± 0.039	3.108ThrSer: 3.108 ± 0.045	2.868ThrThr: 2.868 ± 0.052	4.483ThrVal: 4.483 ± 0.057	0.547ThrTrp: 0.547 ± 0.019	1.987ThrTyr: 1.987 ± 0.039	0.0ThrXaa: 0.0 ± 0.0
Val	5.637ValAla: 5.637 ± 0.068	0.693ValCys: 0.693 ± 0.022	3.511ValAsp: 3.511 ± 0.053	4.901ValGlu: 4.901 ± 0.066	3.117ValPhe: 3.117 ± 0.045	4.752ValGly: 4.752 ± 0.056	1.523ValHis: 1.523 ± 0.034	5.359ValIle: 5.359 ± 0.062	4.195ValLys: 4.195 ± 0.049	7.155ValLeu: 7.155 ± 0.079	2.021ValMet: 2.021 ± 0.032	2.782ValAsn: 2.782 ± 0.041	3.002ValPro: 3.002 ± 0.048	2.76ValGln: 2.76 ± 0.043	3.459ValArg: 3.459 ± 0.056	4.482ValSer: 4.482 ± 0.053	4.241ValThr: 4.241 ± 0.058	5.12ValVal: 5.12 ± 0.063	0.753ValTrp: 0.753 ± 0.021	2.403ValTyr: 2.403 ± 0.043	0.0ValXaa: 0.0 ± 0.0
Trp	0.693TrpAla: 0.693 ± 0.024	0.087TrpCys: 0.087 ± 0.008	0.575TrpAsp: 0.575 ± 0.019	0.744TrpGlu: 0.744 ± 0.025	0.512TrpPhe: 0.512 ± 0.021	0.73TrpGly: 0.73 ± 0.022	0.224TrpHis: 0.224 ± 0.012	0.852TrpIle: 0.852 ± 0.025	0.753TrpLys: 0.753 ± 0.021	1.235TrpLeu: 1.235 ± 0.031	0.403TrpMet: 0.403 ± 0.017	0.53TrpAsn: 0.53 ± 0.017	0.314TrpPro: 0.314 ± 0.015	0.446TrpGln: 0.446 ± 0.019	0.55TrpArg: 0.55 ± 0.017	0.613TrpSer: 0.613 ± 0.019	0.565TrpThr: 0.565 ± 0.02	0.682TrpVal: 0.682 ± 0.02	0.132TrpTrp: 0.132 ± 0.008	0.354TrpTyr: 0.354 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.433TyrAla: 2.433 ± 0.044	0.346TyrCys: 0.346 ± 0.014	1.793TyrAsp: 1.793 ± 0.037	2.519TyrGlu: 2.519 ± 0.041	1.639TyrPhe: 1.639 ± 0.029	2.587TyrGly: 2.587 ± 0.036	0.821TyrHis: 0.821 ± 0.021	2.533TyrIle: 2.533 ± 0.04	1.953TyrLys: 1.953 ± 0.039	3.375TyrLeu: 3.375 ± 0.048	0.923TyrMet: 0.923 ± 0.027	1.351TyrAsn: 1.351 ± 0.031	1.518TyrPro: 1.518 ± 0.035	1.302TyrGln: 1.302 ± 0.032	2.002TyrArg: 2.002 ± 0.034	2.019TyrSer: 2.019 ± 0.036	2.001TyrThr: 2.001 ± 0.039	2.374TyrVal: 2.374 ± 0.04	0.403TyrTrp: 0.403 ± 0.016	1.372TyrTyr: 1.372 ± 0.034	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.001XaaGlu: 0.001 ± 0.001	0.001XaaPhe: 0.001 ± 0.001	0.0XaaGly: 0.0 ± 0.0	0.001XaaHis: 0.001 ± 0.001	0.001XaaIle: 0.001 ± 0.001	0.001XaaLys: 0.001 ± 0.001	0.002XaaLeu: 0.002 ± 0.001	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.001XaaArg: 0.001 ± 0.001	0.002XaaSer: 0.002 ± 0.001	0.001XaaThr: 0.001 ± 0.001	0.001XaaVal: 0.001 ± 0.001	0.001XaaTrp: 0.001 ± 0.001	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5649 proteins (1578181 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---