Amino acid dipepetide frequency for Yersinia phage fHe-Yen3-01

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
11.344AlaAla: 11.344 ± 1.285
1.052AlaCys: 1.052 ± 0.293
6.16AlaAsp: 6.16 ± 1.154
6.836AlaGlu: 6.836 ± 0.833
2.78AlaPhe: 2.78 ± 0.423
7.362AlaGly: 7.362 ± 0.952
2.254AlaHis: 2.254 ± 0.384
4.207AlaIle: 4.207 ± 0.69
7.663AlaLys: 7.663 ± 0.76
8.414AlaLeu: 8.414 ± 0.736
2.104AlaMet: 2.104 ± 0.476
3.531AlaAsn: 3.531 ± 0.586
3.381AlaPro: 3.381 ± 0.426
4.883AlaGln: 4.883 ± 0.769
4.808AlaArg: 4.808 ± 0.636
4.883AlaSer: 4.883 ± 0.67
4.057AlaThr: 4.057 ± 0.642
6.461AlaVal: 6.461 ± 0.778
0.826AlaTrp: 0.826 ± 0.209
3.381AlaTyr: 3.381 ± 0.42
0.0AlaXaa: 0.0 ± 0.0
Cys
0.526CysAla: 0.526 ± 0.218
0.075CysCys: 0.075 ± 0.076
0.676CysAsp: 0.676 ± 0.267
0.526CysGlu: 0.526 ± 0.173
0.376CysPhe: 0.376 ± 0.186
1.202CysGly: 1.202 ± 0.308
0.225CysHis: 0.225 ± 0.127
0.902CysIle: 0.902 ± 0.285
0.451CysLys: 0.451 ± 0.2
0.977CysLeu: 0.977 ± 0.272
0.676CysMet: 0.676 ± 0.262
0.451CysAsn: 0.451 ± 0.195
0.451CysPro: 0.451 ± 0.211
0.301CysGln: 0.301 ± 0.142
0.676CysArg: 0.676 ± 0.257
0.826CysSer: 0.826 ± 0.226
0.601CysThr: 0.601 ± 0.18
0.826CysVal: 0.826 ± 0.28
0.0CysTrp: 0.0 ± 0.0
0.826CysTyr: 0.826 ± 0.292
0.0CysXaa: 0.0 ± 0.0
Asp
6.461AspAla: 6.461 ± 0.548
0.526AspCys: 0.526 ± 0.224
3.907AspAsp: 3.907 ± 0.641
3.831AspGlu: 3.831 ± 0.622
2.329AspPhe: 2.329 ± 0.543
5.184AspGly: 5.184 ± 0.618
0.751AspHis: 0.751 ± 0.318
2.93AspIle: 2.93 ± 0.418
3.681AspLys: 3.681 ± 0.52
5.259AspLeu: 5.259 ± 0.726
2.78AspMet: 2.78 ± 0.469
2.479AspAsn: 2.479 ± 0.497
2.404AspPro: 2.404 ± 0.507
1.427AspGln: 1.427 ± 0.438
2.93AspArg: 2.93 ± 0.623
4.207AspSer: 4.207 ± 0.509
4.583AspThr: 4.583 ± 0.581
5.109AspVal: 5.109 ± 0.79
0.977AspTrp: 0.977 ± 0.309
2.93AspTyr: 2.93 ± 0.434
0.0AspXaa: 0.0 ± 0.0
Glu
6.085GluAla: 6.085 ± 0.537
0.751GluCys: 0.751 ± 0.265
3.381GluAsp: 3.381 ± 0.595
3.907GluGlu: 3.907 ± 0.681
2.028GluPhe: 2.028 ± 0.445
4.508GluGly: 4.508 ± 0.743
1.803GluHis: 1.803 ± 0.386
2.855GluIle: 2.855 ± 0.441
3.456GluLys: 3.456 ± 0.526
5.935GluLeu: 5.935 ± 0.649
2.629GluMet: 2.629 ± 0.521
2.554GluAsn: 2.554 ± 0.413
2.104GluPro: 2.104 ± 0.581
3.606GluGln: 3.606 ± 0.713
3.306GluArg: 3.306 ± 0.461
3.155GluSer: 3.155 ± 0.47
2.705GluThr: 2.705 ± 0.485
4.282GluVal: 4.282 ± 0.608
0.826GluTrp: 0.826 ± 0.209
2.404GluTyr: 2.404 ± 0.375
0.0GluXaa: 0.0 ± 0.0
Phe
2.554PheAla: 2.554 ± 0.389
0.376PheCys: 0.376 ± 0.167
2.329PheAsp: 2.329 ± 0.404
1.578PheGlu: 1.578 ± 0.354
1.202PhePhe: 1.202 ± 0.351
2.855PheGly: 2.855 ± 0.406
0.751PheHis: 0.751 ± 0.232
2.254PheIle: 2.254 ± 0.414
2.254PheLys: 2.254 ± 0.398
2.855PheLeu: 2.855 ± 0.439
1.352PheMet: 1.352 ± 0.346
2.629PheAsn: 2.629 ± 0.443
0.826PhePro: 0.826 ± 0.265
1.653PheGln: 1.653 ± 0.258
2.179PheArg: 2.179 ± 0.395
1.803PheSer: 1.803 ± 0.337
2.254PheThr: 2.254 ± 0.465
1.803PheVal: 1.803 ± 0.264
0.451PheTrp: 0.451 ± 0.169
1.427PheTyr: 1.427 ± 0.386
0.0PheXaa: 0.0 ± 0.0
Gly
5.184GlyAla: 5.184 ± 0.869
1.653GlyCys: 1.653 ± 0.462
5.334GlyAsp: 5.334 ± 0.451
4.508GlyGlu: 4.508 ± 0.539
2.78GlyPhe: 2.78 ± 0.362
5.935GlyGly: 5.935 ± 0.789
0.977GlyHis: 0.977 ± 0.331
4.282GlyIle: 4.282 ± 0.554
6.01GlyLys: 6.01 ± 0.648
5.86GlyLeu: 5.86 ± 0.759
1.878GlyMet: 1.878 ± 0.555
3.08GlyAsn: 3.08 ± 0.457
2.104GlyPro: 2.104 ± 0.355
2.479GlyGln: 2.479 ± 0.353
4.357GlyArg: 4.357 ± 0.512
5.334GlySer: 5.334 ± 0.674
4.057GlyThr: 4.057 ± 0.482
5.109GlyVal: 5.109 ± 0.769
0.826GlyTrp: 0.826 ± 0.245
2.855GlyTyr: 2.855 ± 0.435
0.0GlyXaa: 0.0 ± 0.0
His
1.503HisAla: 1.503 ± 0.355
0.376HisCys: 0.376 ± 0.175
1.878HisAsp: 1.878 ± 0.466
1.127HisGlu: 1.127 ± 0.366
0.676HisPhe: 0.676 ± 0.26
2.104HisGly: 2.104 ± 0.598
0.301HisHis: 0.301 ± 0.169
1.352HisIle: 1.352 ± 0.307
1.127HisLys: 1.127 ± 0.284
1.202HisLeu: 1.202 ± 0.308
0.676HisMet: 0.676 ± 0.171
0.676HisAsn: 0.676 ± 0.226
0.751HisPro: 0.751 ± 0.23
0.826HisGln: 0.826 ± 0.196
1.578HisArg: 1.578 ± 0.253
1.277HisSer: 1.277 ± 0.389
0.977HisThr: 0.977 ± 0.312
0.977HisVal: 0.977 ± 0.242
0.225HisTrp: 0.225 ± 0.135
0.601HisTyr: 0.601 ± 0.229
0.0HisXaa: 0.0 ± 0.0
Ile
3.756IleAla: 3.756 ± 0.369
0.376IleCys: 0.376 ± 0.173
3.306IleAsp: 3.306 ± 0.369
2.254IleGlu: 2.254 ± 0.331
1.427IlePhe: 1.427 ± 0.367
4.132IleGly: 4.132 ± 0.606
1.352IleHis: 1.352 ± 0.314
2.479IleIle: 2.479 ± 0.551
3.982IleLys: 3.982 ± 0.585
3.08IleLeu: 3.08 ± 0.473
1.578IleMet: 1.578 ± 0.298
2.479IleAsn: 2.479 ± 0.39
2.254IlePro: 2.254 ± 0.402
2.028IleGln: 2.028 ± 0.442
3.08IleArg: 3.08 ± 0.398
3.155IleSer: 3.155 ± 0.609
3.606IleThr: 3.606 ± 0.601
3.08IleVal: 3.08 ± 0.492
0.676IleTrp: 0.676 ± 0.23
1.878IleTyr: 1.878 ± 0.438
0.0IleXaa: 0.0 ± 0.0
Lys
6.536LysAla: 6.536 ± 0.813
0.676LysCys: 0.676 ± 0.226
4.432LysAsp: 4.432 ± 0.487
4.432LysGlu: 4.432 ± 0.612
2.404LysPhe: 2.404 ± 0.462
4.432LysGly: 4.432 ± 0.564
1.127LysHis: 1.127 ± 0.3
2.629LysIle: 2.629 ± 0.446
3.456LysLys: 3.456 ± 0.582
6.085LysLeu: 6.085 ± 0.62
2.404LysMet: 2.404 ± 0.48
2.028LysAsn: 2.028 ± 0.452
3.907LysPro: 3.907 ± 0.566
1.878LysGln: 1.878 ± 0.318
3.23LysArg: 3.23 ± 0.626
3.681LysSer: 3.681 ± 0.442
3.381LysThr: 3.381 ± 0.336
4.057LysVal: 4.057 ± 0.482
1.052LysTrp: 1.052 ± 0.245
1.728LysTyr: 1.728 ± 0.326
0.0LysXaa: 0.0 ± 0.0
Leu
9.541LeuAla: 9.541 ± 0.949
1.202LeuCys: 1.202 ± 0.349
6.311LeuAsp: 6.311 ± 0.707
5.259LeuGlu: 5.259 ± 0.62
2.479LeuPhe: 2.479 ± 0.427
5.71LeuGly: 5.71 ± 0.765
2.028LeuHis: 2.028 ± 0.431
4.057LeuIle: 4.057 ± 0.686
4.432LeuLys: 4.432 ± 0.686
5.184LeuLeu: 5.184 ± 0.559
1.878LeuMet: 1.878 ± 0.39
3.756LeuAsn: 3.756 ± 0.412
3.155LeuPro: 3.155 ± 0.366
3.531LeuGln: 3.531 ± 0.462
4.207LeuArg: 4.207 ± 0.606
5.033LeuSer: 5.033 ± 0.55
4.357LeuThr: 4.357 ± 0.621
4.883LeuVal: 4.883 ± 0.61
1.202LeuTrp: 1.202 ± 0.343
2.554LeuTyr: 2.554 ± 0.401
0.0LeuXaa: 0.0 ± 0.0
Met
3.681MetAla: 3.681 ± 0.514
0.301MetCys: 0.301 ± 0.144
1.202MetAsp: 1.202 ± 0.377
1.503MetGlu: 1.503 ± 0.229
0.751MetPhe: 0.751 ± 0.309
2.254MetGly: 2.254 ± 0.561
0.526MetHis: 0.526 ± 0.2
1.653MetIle: 1.653 ± 0.323
2.104MetLys: 2.104 ± 0.42
2.78MetLeu: 2.78 ± 0.421
0.977MetMet: 0.977 ± 0.497
1.803MetAsn: 1.803 ± 0.312
1.277MetPro: 1.277 ± 0.321
1.728MetGln: 1.728 ± 0.466
1.503MetArg: 1.503 ± 0.309
2.78MetSer: 2.78 ± 0.544
1.503MetThr: 1.503 ± 0.321
1.878MetVal: 1.878 ± 0.39
0.225MetTrp: 0.225 ± 0.117
0.601MetTyr: 0.601 ± 0.191
0.0MetXaa: 0.0 ± 0.0
Asn
3.756AsnAla: 3.756 ± 0.659
0.301AsnCys: 0.301 ± 0.133
2.329AsnAsp: 2.329 ± 0.53
1.728AsnGlu: 1.728 ± 0.39
2.104AsnPhe: 2.104 ± 0.355
3.907AsnGly: 3.907 ± 0.553
1.127AsnHis: 1.127 ± 0.277
2.404AsnIle: 2.404 ± 0.461
3.381AsnLys: 3.381 ± 0.557
2.629AsnLeu: 2.629 ± 0.453
1.803AsnMet: 1.803 ± 0.37
1.803AsnAsn: 1.803 ± 0.367
2.028AsnPro: 2.028 ± 0.334
2.104AsnGln: 2.104 ± 0.477
2.554AsnArg: 2.554 ± 0.551
2.254AsnSer: 2.254 ± 0.419
2.479AsnThr: 2.479 ± 0.367
2.404AsnVal: 2.404 ± 0.505
0.601AsnTrp: 0.601 ± 0.173
1.503AsnTyr: 1.503 ± 0.35
0.0AsnXaa: 0.0 ± 0.0
Pro
3.831ProAla: 3.831 ± 0.792
0.451ProCys: 0.451 ± 0.177
2.404ProAsp: 2.404 ± 0.4
3.456ProGlu: 3.456 ± 0.508
1.503ProPhe: 1.503 ± 0.368
2.554ProGly: 2.554 ± 0.469
0.376ProHis: 0.376 ± 0.175
1.503ProIle: 1.503 ± 0.312
1.953ProLys: 1.953 ± 0.354
2.93ProLeu: 2.93 ± 0.379
0.751ProMet: 0.751 ± 0.202
2.629ProAsn: 2.629 ± 0.386
1.127ProPro: 1.127 ± 0.352
1.578ProGln: 1.578 ± 0.277
1.052ProArg: 1.052 ± 0.267
2.179ProSer: 2.179 ± 0.279
2.329ProThr: 2.329 ± 0.339
3.456ProVal: 3.456 ± 0.639
0.376ProTrp: 0.376 ± 0.127
1.953ProTyr: 1.953 ± 0.42
0.0ProXaa: 0.0 ± 0.0
Gln
5.033GlnAla: 5.033 ± 0.588
0.301GlnCys: 0.301 ± 0.169
2.404GlnAsp: 2.404 ± 0.376
2.179GlnGlu: 2.179 ± 0.442
1.503GlnPhe: 1.503 ± 0.382
2.705GlnGly: 2.705 ± 0.408
1.503GlnHis: 1.503 ± 0.388
1.578GlnIle: 1.578 ± 0.313
2.028GlnLys: 2.028 ± 0.387
3.756GlnLeu: 3.756 ± 0.601
1.953GlnMet: 1.953 ± 0.349
1.352GlnAsn: 1.352 ± 0.389
0.902GlnPro: 0.902 ± 0.248
2.179GlnGln: 2.179 ± 0.378
1.953GlnArg: 1.953 ± 0.4
2.179GlnSer: 2.179 ± 0.381
2.104GlnThr: 2.104 ± 0.536
2.629GlnVal: 2.629 ± 0.357
0.902GlnTrp: 0.902 ± 0.262
2.179GlnTyr: 2.179 ± 0.479
0.0GlnXaa: 0.0 ± 0.0
Arg
5.033ArgAla: 5.033 ± 0.729
0.376ArgCys: 0.376 ± 0.204
3.08ArgAsp: 3.08 ± 0.532
3.831ArgGlu: 3.831 ± 0.51
2.629ArgPhe: 2.629 ± 0.313
3.456ArgGly: 3.456 ± 0.535
1.052ArgHis: 1.052 ± 0.216
3.08ArgIle: 3.08 ± 0.575
2.554ArgLys: 2.554 ± 0.515
5.109ArgLeu: 5.109 ± 0.509
1.503ArgMet: 1.503 ± 0.304
2.104ArgAsn: 2.104 ± 0.323
2.028ArgPro: 2.028 ± 0.403
1.953ArgGln: 1.953 ± 0.374
2.78ArgArg: 2.78 ± 0.515
2.554ArgSer: 2.554 ± 0.435
3.606ArgThr: 3.606 ± 0.512
3.681ArgVal: 3.681 ± 0.534
1.202ArgTrp: 1.202 ± 0.309
2.028ArgTyr: 2.028 ± 0.351
0.0ArgXaa: 0.0 ± 0.0
Ser
5.409SerAla: 5.409 ± 0.657
0.376SerCys: 0.376 ± 0.138
4.508SerAsp: 4.508 ± 0.47
4.508SerGlu: 4.508 ± 0.572
1.953SerPhe: 1.953 ± 0.425
4.207SerGly: 4.207 ± 0.527
1.052SerHis: 1.052 ± 0.248
2.629SerIle: 2.629 ± 0.451
3.982SerLys: 3.982 ± 0.538
4.958SerLeu: 4.958 ± 0.659
1.653SerMet: 1.653 ± 0.384
2.78SerAsn: 2.78 ± 0.569
1.803SerPro: 1.803 ± 0.342
2.78SerGln: 2.78 ± 0.533
3.456SerArg: 3.456 ± 0.581
2.479SerSer: 2.479 ± 0.481
3.681SerThr: 3.681 ± 0.455
4.508SerVal: 4.508 ± 0.679
0.676SerTrp: 0.676 ± 0.178
2.104SerTyr: 2.104 ± 0.374
0.0SerXaa: 0.0 ± 0.0
Thr
5.935ThrAla: 5.935 ± 0.941
0.676ThrCys: 0.676 ± 0.275
3.23ThrAsp: 3.23 ± 0.46
3.756ThrGlu: 3.756 ± 0.608
1.878ThrPhe: 1.878 ± 0.355
5.033ThrGly: 5.033 ± 0.522
1.202ThrHis: 1.202 ± 0.253
3.005ThrIle: 3.005 ± 0.539
4.057ThrLys: 4.057 ± 0.549
4.432ThrLeu: 4.432 ± 0.622
1.352ThrMet: 1.352 ± 0.313
1.578ThrAsn: 1.578 ± 0.326
3.005ThrPro: 3.005 ± 0.644
1.052ThrGln: 1.052 ± 0.303
3.23ThrArg: 3.23 ± 0.423
3.681ThrSer: 3.681 ± 0.595
2.705ThrThr: 2.705 ± 0.302
3.606ThrVal: 3.606 ± 0.475
0.601ThrTrp: 0.601 ± 0.206
1.653ThrTyr: 1.653 ± 0.343
0.0ThrXaa: 0.0 ± 0.0
Val
5.935ValAla: 5.935 ± 0.841
0.751ValCys: 0.751 ± 0.247
4.207ValAsp: 4.207 ± 0.506
3.831ValGlu: 3.831 ± 0.452
2.705ValPhe: 2.705 ± 0.408
4.357ValGly: 4.357 ± 0.745
1.277ValHis: 1.277 ± 0.356
3.23ValIle: 3.23 ± 0.447
3.606ValLys: 3.606 ± 0.711
4.808ValLeu: 4.808 ± 0.525
1.803ValMet: 1.803 ± 0.325
2.78ValAsn: 2.78 ± 0.454
3.155ValPro: 3.155 ± 0.549
3.456ValGln: 3.456 ± 0.413
3.606ValArg: 3.606 ± 0.523
4.583ValSer: 4.583 ± 0.5
4.357ValThr: 4.357 ± 0.783
5.559ValVal: 5.559 ± 0.734
0.676ValTrp: 0.676 ± 0.24
2.855ValTyr: 2.855 ± 0.531
0.0ValXaa: 0.0 ± 0.0
Trp
0.826TrpAla: 0.826 ± 0.235
0.15TrpCys: 0.15 ± 0.117
1.052TrpAsp: 1.052 ± 0.315
0.826TrpGlu: 0.826 ± 0.302
0.977TrpPhe: 0.977 ± 0.239
0.526TrpGly: 0.526 ± 0.292
0.301TrpHis: 0.301 ± 0.121
0.526TrpIle: 0.526 ± 0.244
0.676TrpLys: 0.676 ± 0.182
1.728TrpLeu: 1.728 ± 0.44
0.451TrpMet: 0.451 ± 0.23
0.301TrpAsn: 0.301 ± 0.168
0.601TrpPro: 0.601 ± 0.199
0.376TrpGln: 0.376 ± 0.164
0.751TrpArg: 0.751 ± 0.211
0.601TrpSer: 0.601 ± 0.168
0.601TrpThr: 0.601 ± 0.21
0.902TrpVal: 0.902 ± 0.262
0.751TrpTrp: 0.751 ± 0.189
0.451TrpTyr: 0.451 ± 0.216
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.456TyrAla: 3.456 ± 0.427
0.826TyrCys: 0.826 ± 0.235
2.554TyrAsp: 2.554 ± 0.538
2.404TyrGlu: 2.404 ± 0.561
0.902TyrPhe: 0.902 ± 0.238
2.179TyrGly: 2.179 ± 0.392
0.225TyrHis: 0.225 ± 0.145
2.404TyrIle: 2.404 ± 0.572
2.78TyrLys: 2.78 ± 0.402
2.78TyrLeu: 2.78 ± 0.554
0.751TyrMet: 0.751 ± 0.199
2.404TyrAsn: 2.404 ± 0.435
1.127TyrPro: 1.127 ± 0.272
1.503TyrGln: 1.503 ± 0.331
2.404TyrArg: 2.404 ± 0.483
2.855TyrSer: 2.855 ± 0.491
1.728TyrThr: 1.728 ± 0.428
2.329TyrVal: 2.329 ± 0.43
0.301TyrTrp: 0.301 ± 0.149
1.052TyrTyr: 1.052 ± 0.338
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 56 proteins (13312 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski