Amino acid dipepetide frequency for Nitrososphaeraceae archaeon

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.894AlaAla: 4.894 ± 0.128	0.646AlaCys: 0.646 ± 0.031	3.228AlaAsp: 3.228 ± 0.066	3.698AlaGlu: 3.698 ± 0.074	2.615AlaPhe: 2.615 ± 0.059	4.265AlaGly: 4.265 ± 0.077	1.115AlaHis: 1.115 ± 0.042	5.4AlaIle: 5.4 ± 0.09	3.888AlaLys: 3.888 ± 0.072	5.907AlaLeu: 5.907 ± 0.092	1.504AlaMet: 1.504 ± 0.04	2.821AlaAsn: 2.821 ± 0.06	1.784AlaPro: 1.784 ± 0.049	1.934AlaGln: 1.934 ± 0.053	3.009AlaArg: 3.009 ± 0.058	4.603AlaSer: 4.603 ± 0.071	3.531AlaThr: 3.531 ± 0.081	4.276AlaVal: 4.276 ± 0.086	0.532AlaTrp: 0.532 ± 0.026	1.989AlaTyr: 1.989 ± 0.048	0.001AlaXaa: 0.001 ± 0.001
Cys	0.558CysAla: 0.558 ± 0.027	0.184CysCys: 0.184 ± 0.014	0.66CysAsp: 0.66 ± 0.028	0.581CysGlu: 0.581 ± 0.027	0.415CysPhe: 0.415 ± 0.021	1.021CysGly: 1.021 ± 0.037	0.251CysHis: 0.251 ± 0.02	0.774CysIle: 0.774 ± 0.031	0.692CysLys: 0.692 ± 0.029	0.858CysLeu: 0.858 ± 0.033	0.265CysMet: 0.265 ± 0.019	0.567CysAsn: 0.567 ± 0.029	0.62CysPro: 0.62 ± 0.027	0.318CysGln: 0.318 ± 0.022	0.54CysArg: 0.54 ± 0.024	0.905CysSer: 0.905 ± 0.034	0.521CysThr: 0.521 ± 0.026	0.618CysVal: 0.618 ± 0.027	0.086CysTrp: 0.086 ± 0.01	0.386CysTyr: 0.386 ± 0.021	0.0CysXaa: 0.0 ± 0.0
Asp	3.218AspAla: 3.218 ± 0.061	0.591AspCys: 0.591 ± 0.027	3.53AspAsp: 3.53 ± 0.09	3.975AspGlu: 3.975 ± 0.067	2.337AspPhe: 2.337 ± 0.05	3.763AspGly: 3.763 ± 0.071	1.059AspHis: 1.059 ± 0.038	5.019AspIle: 5.019 ± 0.077	3.624AspLys: 3.624 ± 0.074	5.544AspLeu: 5.544 ± 0.08	1.392AspMet: 1.392 ± 0.039	3.094AspAsn: 3.094 ± 0.075	2.55AspPro: 2.55 ± 0.059	1.7AspGln: 1.7 ± 0.043	2.806AspArg: 2.806 ± 0.056	4.296AspSer: 4.296 ± 0.08	2.956AspThr: 2.956 ± 0.058	3.556AspVal: 3.556 ± 0.065	0.532AspTrp: 0.532 ± 0.023	2.108AspTyr: 2.108 ± 0.052	0.0AspXaa: 0.0 ± 0.0
Glu	3.756GluAla: 3.756 ± 0.073	0.658GluCys: 0.658 ± 0.03	3.466GluAsp: 3.466 ± 0.067	4.648GluGlu: 4.648 ± 0.096	2.531GluPhe: 2.531 ± 0.057	3.898GluGly: 3.898 ± 0.079	1.221GluHis: 1.221 ± 0.037	5.996GluIle: 5.996 ± 0.101	4.752GluLys: 4.752 ± 0.075	5.972GluLeu: 5.972 ± 0.094	1.701GluMet: 1.701 ± 0.045	3.523GluAsn: 3.523 ± 0.065	1.852GluPro: 1.852 ± 0.048	2.28GluGln: 2.28 ± 0.052	3.503GluArg: 3.503 ± 0.064	4.44GluSer: 4.44 ± 0.084	2.952GluThr: 2.952 ± 0.063	3.878GluVal: 3.878 ± 0.067	0.63GluTrp: 0.63 ± 0.028	2.485GluTyr: 2.485 ± 0.061	0.0GluXaa: 0.0 ± 0.0
Phe	2.58PheAla: 2.58 ± 0.062	0.516PheCys: 0.516 ± 0.026	2.587PheAsp: 2.587 ± 0.058	2.522PheGlu: 2.522 ± 0.056	1.508PhePhe: 1.508 ± 0.049	2.912PheGly: 2.912 ± 0.066	0.779PheHis: 0.779 ± 0.03	2.852PheIle: 2.852 ± 0.063	2.143PheLys: 2.143 ± 0.049	3.658PheLeu: 3.658 ± 0.079	0.876PheMet: 0.876 ± 0.036	1.842PheAsn: 1.842 ± 0.051	1.669PhePro: 1.669 ± 0.049	1.122PheGln: 1.122 ± 0.042	1.887PheArg: 1.887 ± 0.054	3.198PheSer: 3.198 ± 0.06	2.213PheThr: 2.213 ± 0.055	2.966PheVal: 2.966 ± 0.056	0.392PheTrp: 0.392 ± 0.02	1.332PheTyr: 1.332 ± 0.037	0.0PheXaa: 0.0 ± 0.0
Gly	3.863GlyAla: 3.863 ± 0.078	0.667GlyCys: 0.667 ± 0.029	3.37GlyAsp: 3.37 ± 0.064	3.639GlyGlu: 3.639 ± 0.071	3.008GlyPhe: 3.008 ± 0.066	4.563GlyGly: 4.563 ± 0.097	1.28GlyHis: 1.28 ± 0.037	6.212GlyIle: 6.212 ± 0.097	4.416GlyLys: 4.416 ± 0.076	5.811GlyLeu: 5.811 ± 0.092	1.891GlyMet: 1.891 ± 0.045	3.4GlyAsn: 3.4 ± 0.066	2.061GlyPro: 2.061 ± 0.057	2.005GlyGln: 2.005 ± 0.049	3.205GlyArg: 3.205 ± 0.067	4.988GlySer: 4.988 ± 0.076	3.854GlyThr: 3.854 ± 0.063	4.086GlyVal: 4.086 ± 0.077	0.672GlyTrp: 0.672 ± 0.027	2.456GlyTyr: 2.456 ± 0.053	0.0GlyXaa: 0.0 ± 0.0
His	1.052HisAla: 1.052 ± 0.029	0.246HisCys: 0.246 ± 0.019	1.218HisAsp: 1.218 ± 0.044	1.188HisGlu: 1.188 ± 0.035	0.824HisPhe: 0.824 ± 0.03	1.409HisGly: 1.409 ± 0.038	0.454HisHis: 0.454 ± 0.024	1.474HisIle: 1.474 ± 0.042	1.135HisLys: 1.135 ± 0.039	1.812HisLeu: 1.812 ± 0.05	0.504HisMet: 0.504 ± 0.02	0.951HisAsn: 0.951 ± 0.034	0.951HisPro: 0.951 ± 0.032	0.586HisGln: 0.586 ± 0.025	1.01HisArg: 1.01 ± 0.032	1.524HisSer: 1.524 ± 0.039	1.035HisThr: 1.035 ± 0.04	1.205HisVal: 1.205 ± 0.034	0.198HisTrp: 0.198 ± 0.014	0.731HisTyr: 0.731 ± 0.031	0.0HisXaa: 0.0 ± 0.0
Ile	5.836IleAla: 5.836 ± 0.093	0.979IleCys: 0.979 ± 0.037	5.17IleAsp: 5.17 ± 0.079	5.466IleGlu: 5.466 ± 0.086	3.075IlePhe: 3.075 ± 0.067	5.594IleGly: 5.594 ± 0.102	1.547IleHis: 1.547 ± 0.044	6.474IleIle: 6.474 ± 0.111	4.66IleLys: 4.66 ± 0.074	7.618IleLeu: 7.618 ± 0.115	1.942IleMet: 1.942 ± 0.05	3.889IleAsn: 3.889 ± 0.064	3.639IlePro: 3.639 ± 0.071	2.741IleGln: 2.741 ± 0.054	4.21IleArg: 4.21 ± 0.068	6.983IleSer: 6.983 ± 0.093	4.684IleThr: 4.684 ± 0.08	5.788IleVal: 5.788 ± 0.079	0.67IleTrp: 0.67 ± 0.032	2.359IleTyr: 2.359 ± 0.048	0.0IleXaa: 0.0 ± 0.0
Lys	3.535LysAla: 3.535 ± 0.069	0.68LysCys: 0.68 ± 0.033	3.587LysAsp: 3.587 ± 0.067	4.875LysGlu: 4.875 ± 0.079	2.422LysPhe: 2.422 ± 0.055	3.772LysGly: 3.772 ± 0.07	1.238LysHis: 1.238 ± 0.042	5.515LysIle: 5.515 ± 0.078	4.842LysLys: 4.842 ± 0.1	5.529LysLeu: 5.529 ± 0.09	1.891LysMet: 1.891 ± 0.049	3.367LysAsn: 3.367 ± 0.059	2.233LysPro: 2.233 ± 0.061	2.155LysGln: 2.155 ± 0.051	3.542LysArg: 3.542 ± 0.062	4.393LysSer: 4.393 ± 0.076	3.161LysThr: 3.161 ± 0.066	3.98LysVal: 3.98 ± 0.079	0.689LysTrp: 0.689 ± 0.03	2.568LysTyr: 2.568 ± 0.064	0.0LysXaa: 0.0 ± 0.0
Leu	6.004LeuAla: 6.004 ± 0.093	0.885LeuCys: 0.885 ± 0.032	5.341LeuAsp: 5.341 ± 0.076	6.247LeuGlu: 6.247 ± 0.1	3.406LeuPhe: 3.406 ± 0.074	5.799LeuGly: 5.799 ± 0.09	1.774LeuHis: 1.774 ± 0.052	6.817LeuIle: 6.817 ± 0.102	5.804LeuLys: 5.804 ± 0.09	8.399LeuLeu: 8.399 ± 0.15	2.097LeuMet: 2.097 ± 0.047	4.511LeuAsn: 4.511 ± 0.073	3.615LeuPro: 3.615 ± 0.077	2.999LeuGln: 2.999 ± 0.06	5.068LeuArg: 5.068 ± 0.087	7.553LeuSer: 7.553 ± 0.093	4.945LeuThr: 4.945 ± 0.082	6.292LeuVal: 6.292 ± 0.085	0.728LeuTrp: 0.728 ± 0.033	2.823LeuTyr: 2.823 ± 0.061	0.0LeuXaa: 0.0 ± 0.0
Met	1.55MetAla: 1.55 ± 0.041	0.223MetCys: 0.223 ± 0.018	1.414MetAsp: 1.414 ± 0.039	1.38MetGlu: 1.38 ± 0.038	0.767MetPhe: 0.767 ± 0.034	1.397MetGly: 1.397 ± 0.038	0.532MetHis: 0.532 ± 0.026	2.148MetIle: 2.148 ± 0.046	2.0MetLys: 2.0 ± 0.048	2.262MetLeu: 2.262 ± 0.056	0.673MetMet: 0.673 ± 0.031	1.558MetAsn: 1.558 ± 0.042	1.11MetPro: 1.11 ± 0.035	0.866MetGln: 0.866 ± 0.03	1.206MetArg: 1.206 ± 0.04	2.155MetSer: 2.155 ± 0.051	1.698MetThr: 1.698 ± 0.048	1.71MetVal: 1.71 ± 0.045	0.189MetTrp: 0.189 ± 0.016	0.697MetTyr: 0.697 ± 0.029	0.0MetXaa: 0.0 ± 0.0
Asn	3.121AsnAla: 3.121 ± 0.067	0.555AsnCys: 0.555 ± 0.025	3.064AsnAsp: 3.064 ± 0.062	3.337AsnGlu: 3.337 ± 0.075	1.797AsnPhe: 1.797 ± 0.044	3.491AsnGly: 3.491 ± 0.074	0.993AsnHis: 0.993 ± 0.033	4.253AsnIle: 4.253 ± 0.079	3.064AsnLys: 3.064 ± 0.063	4.562AsnLeu: 4.562 ± 0.084	1.416AsnMet: 1.416 ± 0.047	3.405AsnAsn: 3.405 ± 0.093	2.317AsnPro: 2.317 ± 0.051	1.903AsnGln: 1.903 ± 0.051	2.632AsnArg: 2.632 ± 0.062	4.269AsnSer: 4.269 ± 0.077	2.83AsnThr: 2.83 ± 0.069	3.28AsnVal: 3.28 ± 0.07	0.481AsnTrp: 0.481 ± 0.023	1.615AsnTyr: 1.615 ± 0.047	0.0AsnXaa: 0.0 ± 0.0
Pro	2.124ProAla: 2.124 ± 0.051	0.306ProCys: 0.306 ± 0.02	2.26ProAsp: 2.26 ± 0.054	2.649ProGlu: 2.649 ± 0.053	1.766ProPhe: 1.766 ± 0.049	2.348ProGly: 2.348 ± 0.063	0.806ProHis: 0.806 ± 0.034	3.059ProIle: 3.059 ± 0.061	2.131ProLys: 2.131 ± 0.054	3.346ProLeu: 3.346 ± 0.073	0.908ProMet: 0.908 ± 0.034	1.855ProAsn: 1.855 ± 0.05	1.747ProPro: 1.747 ± 0.051	1.286ProGln: 1.286 ± 0.043	1.758ProArg: 1.758 ± 0.042	3.251ProSer: 3.251 ± 0.066	2.235ProThr: 2.235 ± 0.054	2.628ProVal: 2.628 ± 0.056	0.365ProTrp: 0.365 ± 0.025	1.433ProTyr: 1.433 ± 0.045	0.0ProXaa: 0.0 ± 0.0
Gln	2.005GlnAla: 2.005 ± 0.049	0.301GlnCys: 0.301 ± 0.022	1.682GlnAsp: 1.682 ± 0.048	2.196GlnGlu: 2.196 ± 0.057	1.256GlnPhe: 1.256 ± 0.042	1.86GlnGly: 1.86 ± 0.049	0.618GlnHis: 0.618 ± 0.027	2.884GlnIle: 2.884 ± 0.062	2.169GlnLys: 2.169 ± 0.047	2.925GlnLeu: 2.925 ± 0.066	0.887GlnMet: 0.887 ± 0.034	1.845GlnAsn: 1.845 ± 0.047	1.104GlnPro: 1.104 ± 0.041	1.648GlnGln: 1.648 ± 0.073	1.71GlnArg: 1.71 ± 0.048	2.332GlnSer: 2.332 ± 0.052	1.791GlnThr: 1.791 ± 0.046	2.138GlnVal: 2.138 ± 0.05	0.316GlnTrp: 0.316 ± 0.022	1.114GlnTyr: 1.114 ± 0.044	0.0GlnXaa: 0.0 ± 0.0
Arg	2.639ArgAla: 2.639 ± 0.058	0.598ArgCys: 0.598 ± 0.025	2.675ArgAsp: 2.675 ± 0.05	3.348ArgGlu: 3.348 ± 0.07	1.968ArgPhe: 1.968 ± 0.049	2.923ArgGly: 2.923 ± 0.061	1.101ArgHis: 1.101 ± 0.038	4.832ArgIle: 4.832 ± 0.078	3.809ArgLys: 3.809 ± 0.082	4.867ArgLeu: 4.867 ± 0.079	1.575ArgMet: 1.575 ± 0.043	2.809ArgAsn: 2.809 ± 0.064	1.599ArgPro: 1.599 ± 0.044	1.705ArgGln: 1.705 ± 0.043	2.914ArgArg: 2.914 ± 0.069	3.639ArgSer: 3.639 ± 0.067	2.645ArgThr: 2.645 ± 0.062	2.929ArgVal: 2.929 ± 0.063	0.494ArgTrp: 0.494 ± 0.027	2.016ArgTyr: 2.016 ± 0.05	0.0ArgXaa: 0.0 ± 0.0
Ser	4.619SerAla: 4.619 ± 0.088	0.794SerCys: 0.794 ± 0.034	4.469SerAsp: 4.469 ± 0.082	4.423SerGlu: 4.423 ± 0.086	3.228SerPhe: 3.228 ± 0.076	5.154SerGly: 5.154 ± 0.082	1.545SerHis: 1.545 ± 0.044	6.412SerIle: 6.412 ± 0.093	5.155SerLys: 5.155 ± 0.079	7.156SerLeu: 7.156 ± 0.099	2.061SerMet: 2.061 ± 0.047	4.525SerAsn: 4.525 ± 0.092	2.989SerPro: 2.989 ± 0.071	2.57SerGln: 2.57 ± 0.06	3.73SerArg: 3.73 ± 0.072	7.253SerSer: 7.253 ± 0.139	4.638SerThr: 4.638 ± 0.092	4.712SerVal: 4.712 ± 0.066	0.746SerTrp: 0.746 ± 0.029	2.552SerTyr: 2.552 ± 0.059	0.0SerXaa: 0.0 ± 0.0
Thr	3.488ThrAla: 3.488 ± 0.065	0.519ThrCys: 0.519 ± 0.028	3.064ThrAsp: 3.064 ± 0.06	3.435ThrGlu: 3.435 ± 0.064	2.193ThrPhe: 2.193 ± 0.053	4.005ThrGly: 4.005 ± 0.071	1.011ThrHis: 1.011 ± 0.036	4.57ThrIle: 4.57 ± 0.066	3.366ThrLys: 3.366 ± 0.058	4.881ThrLeu: 4.881 ± 0.072	1.352ThrMet: 1.352 ± 0.043	2.977ThrAsn: 2.977 ± 0.064	2.255ThrPro: 2.255 ± 0.053	1.601ThrGln: 1.601 ± 0.047	2.705ThrArg: 2.705 ± 0.059	4.452ThrSer: 4.452 ± 0.081	3.363ThrThr: 3.363 ± 0.073	3.615ThrVal: 3.615 ± 0.07	0.465ThrTrp: 0.465 ± 0.024	1.774ThrTyr: 1.774 ± 0.049	0.001ThrXaa: 0.001 ± 0.001
Val	4.319ValAla: 4.319 ± 0.074	0.814ValCys: 0.814 ± 0.031	3.893ValAsp: 3.893 ± 0.061	3.957ValGlu: 3.957 ± 0.077	2.569ValPhe: 2.569 ± 0.054	4.241ValGly: 4.241 ± 0.084	1.132ValHis: 1.132 ± 0.033	5.536ValIle: 5.536 ± 0.103	3.878ValLys: 3.878 ± 0.07	5.807ValLeu: 5.807 ± 0.082	1.615ValMet: 1.615 ± 0.045	3.11ValAsn: 3.11 ± 0.065	2.477ValPro: 2.477 ± 0.062	1.909ValGln: 1.909 ± 0.049	3.318ValArg: 3.318 ± 0.065	5.143ValSer: 5.143 ± 0.084	3.918ValThr: 3.918 ± 0.072	4.622ValVal: 4.622 ± 0.085	0.576ValTrp: 0.576 ± 0.024	2.215ValTyr: 2.215 ± 0.05	0.0ValXaa: 0.0 ± 0.0
Trp	0.508TrpAla: 0.508 ± 0.027	0.135TrpCys: 0.135 ± 0.013	0.533TrpAsp: 0.533 ± 0.028	0.508TrpGlu: 0.508 ± 0.023	0.413TrpPhe: 0.413 ± 0.025	0.553TrpGly: 0.553 ± 0.031	0.232TrpHis: 0.232 ± 0.017	0.79TrpIle: 0.79 ± 0.029	0.752TrpLys: 0.752 ± 0.034	0.889TrpLeu: 0.889 ± 0.033	0.249TrpMet: 0.249 ± 0.018	0.625TrpAsn: 0.625 ± 0.027	0.272TrpPro: 0.272 ± 0.017	0.291TrpGln: 0.291 ± 0.021	0.444TrpArg: 0.444 ± 0.025	0.567TrpSer: 0.567 ± 0.029	0.477TrpThr: 0.477 ± 0.027	0.55TrpVal: 0.55 ± 0.026	0.138TrpTrp: 0.138 ± 0.013	0.375TrpTyr: 0.375 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.973TyrAla: 1.973 ± 0.052	0.522TyrCys: 0.522 ± 0.026	2.44TyrAsp: 2.44 ± 0.056	2.069TyrGlu: 2.069 ± 0.053	1.456TyrPhe: 1.456 ± 0.046	2.478TyrGly: 2.478 ± 0.054	0.82TyrHis: 0.82 ± 0.03	2.304TyrIle: 2.304 ± 0.051	1.694TyrLys: 1.694 ± 0.051	3.304TyrLeu: 3.304 ± 0.064	0.734TyrMet: 0.734 ± 0.03	1.709TyrAsn: 1.709 ± 0.047	1.419TyrPro: 1.419 ± 0.043	1.16TyrGln: 1.16 ± 0.039	1.891TyrArg: 1.891 ± 0.051	2.787TyrSer: 2.787 ± 0.057	1.642TyrThr: 1.642 ± 0.043	2.219TyrVal: 2.219 ± 0.055	0.403TyrTrp: 0.403 ± 0.026	1.576TyrTyr: 1.576 ± 0.043	0.001TyrXaa: 0.001 ± 0.001
Xaa	0.0XaaAla: 0.0 ± 0.0	0.001XaaCys: 0.001 ± 0.001	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.002XaaMet: 0.002 ± 0.002	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.007XaaXaa: 0.007 ± 0.004

Statistics based on 3773 proteins (824061 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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