Amino acid dipepetide frequency for Hypholoma sublateritium (strain FD-334 SS-4)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	10.264AlaAla: 10.264 ± 0.068	1.27AlaCys: 1.27 ± 0.013	4.48AlaAsp: 4.48 ± 0.026	4.791AlaGlu: 4.791 ± 0.037	3.392AlaPhe: 3.392 ± 0.025	5.867AlaGly: 5.867 ± 0.037	2.582AlaHis: 2.582 ± 0.026	4.265AlaIle: 4.265 ± 0.028	3.675AlaLys: 3.675 ± 0.033	8.937AlaLeu: 8.937 ± 0.041	1.872AlaMet: 1.872 ± 0.017	2.935AlaAsn: 2.935 ± 0.023	6.482AlaPro: 6.482 ± 0.054	3.535AlaGln: 3.535 ± 0.026	6.188AlaArg: 6.188 ± 0.041	7.98AlaSer: 7.98 ± 0.045	5.565AlaThr: 5.565 ± 0.033	5.67AlaVal: 5.67 ± 0.035	1.163AlaTrp: 1.163 ± 0.013	2.348AlaTyr: 2.348 ± 0.019	0.017AlaXaa: 0.017 ± 0.002
Cys	1.305CysAla: 1.305 ± 0.016	0.295CysCys: 0.295 ± 0.007	0.669CysAsp: 0.669 ± 0.01	0.552CysGlu: 0.552 ± 0.011	0.534CysPhe: 0.534 ± 0.009	0.968CysGly: 0.968 ± 0.014	0.382CysHis: 0.382 ± 0.008	0.796CysIle: 0.796 ± 0.01	0.498CysLys: 0.498 ± 0.009	1.313CysLeu: 1.313 ± 0.015	0.29CysMet: 0.29 ± 0.008	0.44CysAsn: 0.44 ± 0.009	0.891CysPro: 0.891 ± 0.019	0.434CysGln: 0.434 ± 0.008	0.886CysArg: 0.886 ± 0.012	1.101CysSer: 1.101 ± 0.015	0.889CysThr: 0.889 ± 0.013	0.908CysVal: 0.908 ± 0.013	0.191CysTrp: 0.191 ± 0.005	0.342CysTyr: 0.342 ± 0.008	0.004CysXaa: 0.004 ± 0.001
Asp	5.126AspAla: 5.126 ± 0.034	0.611AspCys: 0.611 ± 0.01	4.087AspAsp: 4.087 ± 0.036	3.86AspGlu: 3.86 ± 0.032	2.057AspPhe: 2.057 ± 0.016	3.705AspGly: 3.705 ± 0.027	1.217AspHis: 1.217 ± 0.013	3.214AspIle: 3.214 ± 0.024	1.999AspLys: 1.999 ± 0.018	4.665AspLeu: 4.665 ± 0.031	1.19AspMet: 1.19 ± 0.013	1.758AspAsn: 1.758 ± 0.017	3.241AspPro: 3.241 ± 0.025	1.501AspGln: 1.501 ± 0.017	2.659AspArg: 2.659 ± 0.023	3.985AspSer: 3.985 ± 0.03	3.004AspThr: 3.004 ± 0.021	3.694AspVal: 3.694 ± 0.024	0.804AspTrp: 0.804 ± 0.011	1.409AspTyr: 1.409 ± 0.015	0.012AspXaa: 0.012 ± 0.002
Glu	4.68GluAla: 4.68 ± 0.033	0.646GluCys: 0.646 ± 0.009	3.698GluAsp: 3.698 ± 0.034	4.548GluGlu: 4.548 ± 0.043	1.796GluPhe: 1.796 ± 0.017	3.249GluGly: 3.249 ± 0.026	1.405GluHis: 1.405 ± 0.014	2.94GluIle: 2.94 ± 0.026	2.848GluLys: 2.848 ± 0.027	4.757GluLeu: 4.757 ± 0.027	1.213GluMet: 1.213 ± 0.014	1.989GluAsn: 1.989 ± 0.018	2.514GluPro: 2.514 ± 0.024	1.974GluGln: 1.974 ± 0.019	3.727GluArg: 3.727 ± 0.035	3.782GluSer: 3.782 ± 0.027	2.924GluThr: 2.924 ± 0.025	3.212GluVal: 3.212 ± 0.027	0.825GluTrp: 0.825 ± 0.011	1.521GluTyr: 1.521 ± 0.015	0.01GluXaa: 0.01 ± 0.001
Phe	3.218PheAla: 3.218 ± 0.025	0.603PheCys: 0.603 ± 0.01	2.245PheAsp: 2.245 ± 0.019	1.92PheGlu: 1.92 ± 0.017	1.679PhePhe: 1.679 ± 0.018	2.575PheGly: 2.575 ± 0.022	0.977PheHis: 0.977 ± 0.012	1.875PheIle: 1.875 ± 0.018	1.478PheLys: 1.478 ± 0.015	3.563PheLeu: 3.563 ± 0.026	0.763PheMet: 0.763 ± 0.01	1.469PheAsn: 1.469 ± 0.016	2.191PhePro: 2.191 ± 0.02	1.311PheGln: 1.311 ± 0.014	1.984PheArg: 1.984 ± 0.019	3.242PheSer: 3.242 ± 0.027	2.208PheThr: 2.208 ± 0.018	2.481PheVal: 2.481 ± 0.021	0.56PheTrp: 0.56 ± 0.01	1.076PheTyr: 1.076 ± 0.014	0.007PheXaa: 0.007 ± 0.001
Gly	5.745GlyAla: 5.745 ± 0.04	0.896GlyCys: 0.896 ± 0.014	3.166GlyAsp: 3.166 ± 0.026	3.093GlyGlu: 3.093 ± 0.024	2.403GlyPhe: 2.403 ± 0.022	5.36GlyGly: 5.36 ± 0.048	1.621GlyHis: 1.621 ± 0.015	3.242GlyIle: 3.242 ± 0.027	2.988GlyLys: 2.988 ± 0.021	5.432GlyLeu: 5.432 ± 0.031	1.401GlyMet: 1.401 ± 0.017	2.245GlyAsn: 2.245 ± 0.021	3.426GlyPro: 3.426 ± 0.027	2.08GlyGln: 2.08 ± 0.019	4.061GlyArg: 4.061 ± 0.028	5.292GlySer: 5.292 ± 0.038	3.955GlyThr: 3.955 ± 0.03	4.16GlyVal: 4.16 ± 0.024	1.055GlyTrp: 1.055 ± 0.012	1.77GlyTyr: 1.77 ± 0.02	0.012GlyXaa: 0.012 ± 0.002
His	2.551HisAla: 2.551 ± 0.022	0.418HisCys: 0.418 ± 0.007	1.325HisAsp: 1.325 ± 0.016	1.241HisGlu: 1.241 ± 0.014	1.032HisPhe: 1.032 ± 0.012	1.709HisGly: 1.709 ± 0.016	0.929HisHis: 0.929 ± 0.015	1.53HisIle: 1.53 ± 0.015	0.89HisLys: 0.89 ± 0.011	2.567HisLeu: 2.567 ± 0.02	0.502HisMet: 0.502 ± 0.01	0.868HisAsn: 0.868 ± 0.011	2.112HisPro: 2.112 ± 0.02	0.928HisGln: 0.928 ± 0.012	1.853HisArg: 1.853 ± 0.019	2.139HisSer: 2.139 ± 0.018	1.63HisThr: 1.63 ± 0.017	1.599HisVal: 1.599 ± 0.014	0.345HisTrp: 0.345 ± 0.008	0.707HisTyr: 0.707 ± 0.01	0.007HisXaa: 0.007 ± 0.001
Ile	4.377IleAla: 4.377 ± 0.03	0.807IleCys: 0.807 ± 0.011	2.801IleAsp: 2.801 ± 0.02	2.54IleGlu: 2.54 ± 0.022	2.167IlePhe: 2.167 ± 0.019	2.945IleGly: 2.945 ± 0.022	1.374IleHis: 1.374 ± 0.015	2.659IleIle: 2.659 ± 0.021	2.056IleLys: 2.056 ± 0.02	4.814IleLeu: 4.814 ± 0.036	0.993IleMet: 0.993 ± 0.011	1.813IleAsn: 1.813 ± 0.017	3.451IlePro: 3.451 ± 0.025	1.88IleGln: 1.88 ± 0.017	2.863IleArg: 2.863 ± 0.025	4.302IleSer: 4.302 ± 0.027	2.968IleThr: 2.968 ± 0.021	3.284IleVal: 3.284 ± 0.025	0.764IleTrp: 0.764 ± 0.011	1.464IleTyr: 1.464 ± 0.015	0.011IleXaa: 0.011 ± 0.001
Lys	3.982LysAla: 3.982 ± 0.033	0.52LysCys: 0.52 ± 0.009	2.278LysAsp: 2.278 ± 0.023	2.74LysGlu: 2.74 ± 0.023	1.42LysPhe: 1.42 ± 0.014	2.526LysGly: 2.526 ± 0.023	1.107LysHis: 1.107 ± 0.015	2.159LysIle: 2.159 ± 0.019	2.847LysLys: 2.847 ± 0.027	3.719LysLeu: 3.719 ± 0.028	0.918LysMet: 0.918 ± 0.012	1.57LysAsn: 1.57 ± 0.018	2.292LysPro: 2.292 ± 0.019	1.515LysGln: 1.515 ± 0.016	3.128LysArg: 3.128 ± 0.025	3.144LysSer: 3.144 ± 0.023	2.542LysThr: 2.542 ± 0.02	2.453LysVal: 2.453 ± 0.021	0.613LysTrp: 0.613 ± 0.011	1.244LysTyr: 1.244 ± 0.013	0.005LysXaa: 0.005 ± 0.001
Leu	8.361LeuAla: 8.361 ± 0.041	1.372LeuCys: 1.372 ± 0.016	5.037LeuAsp: 5.037 ± 0.034	5.048LeuGlu: 5.048 ± 0.032	3.426LeuPhe: 3.426 ± 0.024	5.464LeuGly: 5.464 ± 0.035	2.575LeuHis: 2.575 ± 0.025	4.065LeuIle: 4.065 ± 0.03	3.94LeuLys: 3.94 ± 0.028	8.657LeuLeu: 8.657 ± 0.048	1.696LeuMet: 1.696 ± 0.016	3.125LeuAsn: 3.125 ± 0.023	6.4LeuPro: 6.4 ± 0.032	3.688LeuGln: 3.688 ± 0.028	6.195LeuArg: 6.195 ± 0.037	7.855LeuSer: 7.855 ± 0.039	5.137LeuThr: 5.137 ± 0.032	5.595LeuVal: 5.595 ± 0.029	1.219LeuTrp: 1.219 ± 0.013	2.348LeuTyr: 2.348 ± 0.02	0.016LeuXaa: 0.016 ± 0.002
Met	1.833MetAla: 1.833 ± 0.017	0.269MetCys: 0.269 ± 0.006	1.205MetAsp: 1.205 ± 0.013	1.1MetGlu: 1.1 ± 0.013	0.735MetPhe: 0.735 ± 0.011	1.252MetGly: 1.252 ± 0.017	0.604MetHis: 0.604 ± 0.009	0.889MetIle: 0.889 ± 0.013	0.898MetLys: 0.898 ± 0.012	1.781MetLeu: 1.781 ± 0.018	0.457MetMet: 0.457 ± 0.008	0.735MetAsn: 0.735 ± 0.012	1.33MetPro: 1.33 ± 0.015	0.83MetGln: 0.83 ± 0.013	1.335MetArg: 1.335 ± 0.015	1.855MetSer: 1.855 ± 0.018	1.181MetThr: 1.181 ± 0.013	1.109MetVal: 1.109 ± 0.013	0.256MetTrp: 0.256 ± 0.006	0.581MetTyr: 0.581 ± 0.01	0.004MetXaa: 0.004 ± 0.001
Asn	3.194AsnAla: 3.194 ± 0.022	0.414AsnCys: 0.414 ± 0.009	1.796AsnAsp: 1.796 ± 0.018	1.749AsnGlu: 1.749 ± 0.016	1.365AsnPhe: 1.365 ± 0.015	2.518AsnGly: 2.518 ± 0.025	0.855AsnHis: 0.855 ± 0.011	2.143AsnIle: 2.143 ± 0.019	1.373AsnLys: 1.373 ± 0.016	3.254AsnLeu: 3.254 ± 0.026	0.784AsnMet: 0.784 ± 0.011	1.395AsnAsn: 1.395 ± 0.017	2.36AsnPro: 2.36 ± 0.02	1.159AsnGln: 1.159 ± 0.014	1.74AsnArg: 1.74 ± 0.016	2.74AsnSer: 2.74 ± 0.02	2.207AsnThr: 2.207 ± 0.017	2.368AsnVal: 2.368 ± 0.021	0.512AsnTrp: 0.512 ± 0.008	0.912AsnTyr: 0.912 ± 0.014	0.008AsnXaa: 0.008 ± 0.001
Pro	6.747ProAla: 6.747 ± 0.046	0.698ProCys: 0.698 ± 0.012	3.091ProAsp: 3.091 ± 0.025	3.336ProGlu: 3.336 ± 0.022	2.283ProPhe: 2.283 ± 0.022	3.857ProGly: 3.857 ± 0.026	1.799ProHis: 1.799 ± 0.021	2.885ProIle: 2.885 ± 0.023	2.425ProLys: 2.425 ± 0.023	5.636ProLeu: 5.636 ± 0.033	1.113ProMet: 1.113 ± 0.014	2.242ProAsn: 2.242 ± 0.019	7.056ProPro: 7.056 ± 0.073	2.406ProGln: 2.406 ± 0.026	4.276ProArg: 4.276 ± 0.034	6.86ProSer: 6.86 ± 0.047	4.722ProThr: 4.722 ± 0.031	3.926ProVal: 3.926 ± 0.03	0.713ProTrp: 0.713 ± 0.011	1.588ProTyr: 1.588 ± 0.016	0.014ProXaa: 0.014 ± 0.002
Gln	3.309GlnAla: 3.309 ± 0.025	0.513GlnCys: 0.513 ± 0.01	1.759GlnAsp: 1.759 ± 0.018	1.99GlnGlu: 1.99 ± 0.021	1.257GlnPhe: 1.257 ± 0.013	1.991GlnGly: 1.991 ± 0.019	1.096GlnHis: 1.096 ± 0.016	1.863GlnIle: 1.863 ± 0.018	1.595GlnLys: 1.595 ± 0.016	3.254GlnLeu: 3.254 ± 0.021	0.797GlnMet: 0.797 ± 0.011	1.365GlnAsn: 1.365 ± 0.015	2.388GlnPro: 2.388 ± 0.027	2.078GlnGln: 2.078 ± 0.052	2.566GlnArg: 2.566 ± 0.022	2.839GlnSer: 2.839 ± 0.028	2.197GlnThr: 2.197 ± 0.016	1.989GlnVal: 1.989 ± 0.019	0.544GlnTrp: 0.544 ± 0.009	1.071GlnTyr: 1.071 ± 0.014	0.006GlnXaa: 0.006 ± 0.001
Arg	6.022ArgAla: 6.022 ± 0.046	0.988ArgCys: 0.988 ± 0.015	3.069ArgAsp: 3.069 ± 0.025	3.507ArgGlu: 3.507 ± 0.032	2.133ArgPhe: 2.133 ± 0.017	3.816ArgGly: 3.816 ± 0.027	1.747ArgHis: 1.747 ± 0.017	3.115ArgIle: 3.115 ± 0.023	3.151ArgLys: 3.151 ± 0.027	5.713ArgLeu: 5.713 ± 0.033	1.351ArgMet: 1.351 ± 0.014	2.175ArgAsn: 2.175 ± 0.018	4.047ArgPro: 4.047 ± 0.029	2.354ArgGln: 2.354 ± 0.022	5.974ArgArg: 5.974 ± 0.055	5.24ArgSer: 5.24 ± 0.035	3.866ArgThr: 3.866 ± 0.03	3.732ArgVal: 3.732 ± 0.027	0.948ArgTrp: 0.948 ± 0.011	1.624ArgTyr: 1.624 ± 0.017	0.011ArgXaa: 0.011 ± 0.001
Ser	7.869SerAla: 7.869 ± 0.047	1.024SerCys: 1.024 ± 0.014	4.202SerAsp: 4.202 ± 0.029	3.874SerGlu: 3.874 ± 0.027	3.155SerPhe: 3.155 ± 0.025	5.364SerGly: 5.364 ± 0.029	2.112SerHis: 2.112 ± 0.018	4.212SerIle: 4.212 ± 0.029	3.338SerLys: 3.338 ± 0.025	7.635SerLeu: 7.635 ± 0.039	1.676SerMet: 1.676 ± 0.015	2.878SerAsn: 2.878 ± 0.022	6.251SerPro: 6.251 ± 0.049	2.965SerGln: 2.965 ± 0.024	5.206SerArg: 5.206 ± 0.032	9.158SerSer: 9.158 ± 0.065	6.112SerThr: 6.112 ± 0.045	5.055SerVal: 5.055 ± 0.033	1.056SerTrp: 1.056 ± 0.012	1.967SerTyr: 1.967 ± 0.018	0.015SerXaa: 0.015 ± 0.002
Thr	5.662ThrAla: 5.662 ± 0.031	0.804ThrCys: 0.804 ± 0.014	2.778ThrAsp: 2.778 ± 0.022	2.739ThrGlu: 2.739 ± 0.024	2.433ThrPhe: 2.433 ± 0.022	3.83ThrGly: 3.83 ± 0.023	1.667ThrHis: 1.667 ± 0.015	3.132ThrIle: 3.132 ± 0.025	2.319ThrLys: 2.319 ± 0.023	5.85ThrLeu: 5.85 ± 0.035	1.151ThrMet: 1.151 ± 0.015	2.052ThrAsn: 2.052 ± 0.02	4.936ThrPro: 4.936 ± 0.039	2.101ThrGln: 2.101 ± 0.021	3.647ThrArg: 3.647 ± 0.024	5.712ThrSer: 5.712 ± 0.038	4.451ThrThr: 4.451 ± 0.036	3.805ThrVal: 3.805 ± 0.029	0.815ThrTrp: 0.815 ± 0.011	1.626ThrTyr: 1.626 ± 0.016	0.012ThrXaa: 0.012 ± 0.001
Val	5.553ValAla: 5.553 ± 0.03	0.915ValCys: 0.915 ± 0.013	3.707ValAsp: 3.707 ± 0.025	3.533ValGlu: 3.533 ± 0.028	2.487ValPhe: 2.487 ± 0.02	3.789ValGly: 3.789 ± 0.027	1.724ValHis: 1.724 ± 0.016	3.094ValIle: 3.094 ± 0.026	2.607ValLys: 2.607 ± 0.022	5.885ValLeu: 5.885 ± 0.029	1.167ValMet: 1.167 ± 0.013	2.139ValAsn: 2.139 ± 0.018	4.095ValPro: 4.095 ± 0.029	2.293ValGln: 2.293 ± 0.018	3.68ValArg: 3.68 ± 0.025	4.772ValSer: 4.772 ± 0.025	3.401ValThr: 3.401 ± 0.022	4.375ValVal: 4.375 ± 0.028	0.867ValTrp: 0.867 ± 0.011	1.77ValTyr: 1.77 ± 0.017	0.009ValXaa: 0.009 ± 0.001
Trp	1.167TrpAla: 1.167 ± 0.013	0.221TrpCys: 0.221 ± 0.006	0.847TrpAsp: 0.847 ± 0.011	0.769TrpGlu: 0.769 ± 0.011	0.536TrpPhe: 0.536 ± 0.009	0.847TrpGly: 0.847 ± 0.012	0.338TrpHis: 0.338 ± 0.007	0.78TrpIle: 0.78 ± 0.011	0.762TrpLys: 0.762 ± 0.011	1.212TrpLeu: 1.212 ± 0.014	0.332TrpMet: 0.332 ± 0.007	0.626TrpAsn: 0.626 ± 0.011	0.627TrpPro: 0.627 ± 0.01	0.442TrpGln: 0.442 ± 0.008	0.989TrpArg: 0.989 ± 0.014	0.993TrpSer: 0.993 ± 0.013	0.909TrpThr: 0.909 ± 0.011	0.824TrpVal: 0.824 ± 0.012	0.258TrpTrp: 0.258 ± 0.007	0.388TrpTyr: 0.388 ± 0.008	0.002TrpXaa: 0.002 ± 0.001
Tyr	2.293TyrAla: 2.293 ± 0.022	0.4TyrCys: 0.4 ± 0.007	1.549TyrAsp: 1.549 ± 0.017	1.317TyrGlu: 1.317 ± 0.015	1.127TyrPhe: 1.127 ± 0.014	1.76TyrGly: 1.76 ± 0.021	0.764TyrHis: 0.764 ± 0.011	1.468TyrIle: 1.468 ± 0.015	1.027TyrLys: 1.027 ± 0.013	2.558TyrLeu: 2.558 ± 0.024	0.564TyrMet: 0.564 ± 0.009	1.025TyrAsn: 1.025 ± 0.012	1.574TyrPro: 1.574 ± 0.015	0.988TyrGln: 0.988 ± 0.012	1.611TyrArg: 1.611 ± 0.014	2.115TyrSer: 2.115 ± 0.02	1.646TyrThr: 1.646 ± 0.014	1.611TyrVal: 1.611 ± 0.016	0.358TyrTrp: 0.358 ± 0.007	0.856TyrTyr: 0.856 ± 0.012	0.005TyrXaa: 0.005 ± 0.001
Xaa	0.017XaaAla: 0.017 ± 0.002	0.003XaaCys: 0.003 ± 0.001	0.012XaaAsp: 0.012 ± 0.001	0.01XaaGlu: 0.01 ± 0.002	0.008XaaPhe: 0.008 ± 0.001	0.01XaaGly: 0.01 ± 0.001	0.006XaaHis: 0.006 ± 0.001	0.008XaaIle: 0.008 ± 0.001	0.009XaaLys: 0.009 ± 0.001	0.017XaaLeu: 0.017 ± 0.002	0.004XaaMet: 0.004 ± 0.001	0.006XaaAsn: 0.006 ± 0.001	0.012XaaPro: 0.012 ± 0.001	0.008XaaGln: 0.008 ± 0.001	0.013XaaArg: 0.013 ± 0.001	0.018XaaSer: 0.018 ± 0.002	0.01XaaThr: 0.01 ± 0.001	0.011XaaVal: 0.011 ± 0.002	0.003XaaTrp: 0.003 ± 0.001	0.005XaaTyr: 0.005 ± 0.001	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 17638 proteins (6809349 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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