Amino acid dipepetide frequency for Piper yellow mottle virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.805AlaAla: 3.805 ± 1.86
0.423AlaCys: 0.423 ± 0.207
2.537AlaAsp: 2.537 ± 0.84
4.651AlaGlu: 4.651 ± 2.395
2.114AlaPhe: 2.114 ± 1.034
3.383AlaGly: 3.383 ± 1.019
0.846AlaHis: 0.846 ± 1.096
3.805AlaIle: 3.805 ± 1.888
3.805AlaLys: 3.805 ± 2.785
6.765AlaLeu: 6.765 ± 2.445
2.96AlaMet: 2.96 ± 0.894
2.114AlaAsn: 2.114 ± 1.034
1.268AlaPro: 1.268 ± 0.62
4.228AlaGln: 4.228 ± 1.425
2.96AlaArg: 2.96 ± 2.464
2.96AlaSer: 2.96 ± 0.943
3.383AlaThr: 3.383 ± 2.982
4.228AlaVal: 4.228 ± 1.249
0.423AlaTrp: 0.423 ± 0.207
2.537AlaTyr: 2.537 ± 0.84
0.0AlaXaa: 0.0 ± 0.0
Cys
1.691CysAla: 1.691 ± 0.978
1.268CysCys: 1.268 ± 0.62
0.423CysAsp: 0.423 ± 0.207
0.423CysGlu: 0.423 ± 0.207
0.846CysPhe: 0.846 ± 0.413
0.846CysGly: 0.846 ± 0.413
0.0CysHis: 0.0 ± 0.0
1.268CysIle: 1.268 ± 0.62
2.96CysLys: 2.96 ± 1.447
0.846CysLeu: 0.846 ± 1.096
0.423CysMet: 0.423 ± 0.207
1.691CysAsn: 1.691 ± 0.947
0.423CysPro: 0.423 ± 0.207
1.691CysGln: 1.691 ± 0.978
0.0CysArg: 0.0 ± 0.0
1.691CysSer: 1.691 ± 0.827
0.846CysThr: 0.846 ± 1.195
0.0CysVal: 0.0 ± 0.0
0.423CysTrp: 0.423 ± 0.207
0.423CysTyr: 0.423 ± 0.207
0.0CysXaa: 0.0 ± 0.0
Asp
2.96AspAla: 2.96 ± 1.206
2.114AspCys: 2.114 ± 0.921
3.805AspAsp: 3.805 ± 1.128
2.537AspGlu: 2.537 ± 1.24
2.537AspPhe: 2.537 ± 1.24
3.383AspGly: 3.383 ± 0.981
1.268AspHis: 1.268 ± 0.981
2.537AspIle: 2.537 ± 1.24
2.537AspLys: 2.537 ± 1.24
6.765AspLeu: 6.765 ± 1.54
0.846AspMet: 0.846 ± 0.413
2.96AspAsn: 2.96 ± 1.447
3.805AspPro: 3.805 ± 1.104
3.383AspGln: 3.383 ± 3.863
2.114AspArg: 2.114 ± 0.933
2.114AspSer: 2.114 ± 0.921
1.691AspThr: 1.691 ± 0.827
2.96AspVal: 2.96 ± 2.041
1.268AspTrp: 1.268 ± 1.003
2.114AspTyr: 2.114 ± 0.921
0.0AspXaa: 0.0 ± 0.0
Glu
8.879GluAla: 8.879 ± 3.694
0.423GluCys: 0.423 ± 1.338
7.611GluAsp: 7.611 ± 2.886
14.376GluGlu: 14.376 ± 1.886
1.268GluPhe: 1.268 ± 0.62
6.342GluGly: 6.342 ± 1.129
0.846GluHis: 0.846 ± 1.096
5.92GluIle: 5.92 ± 1.23
6.765GluLys: 6.765 ± 5.783
5.92GluLeu: 5.92 ± 2.311
0.423GluMet: 0.423 ± 0.207
3.805GluAsn: 3.805 ± 1.104
2.114GluPro: 2.114 ± 3.51
2.537GluGln: 2.537 ± 1.308
5.074GluArg: 5.074 ± 2.963
2.537GluSer: 2.537 ± 1.308
1.268GluThr: 1.268 ± 0.62
5.92GluVal: 5.92 ± 1.608
1.691GluTrp: 1.691 ± 0.978
1.691GluTyr: 1.691 ± 0.827
0.0GluXaa: 0.0 ± 0.0
Phe
1.691PheAla: 1.691 ± 0.827
0.846PheCys: 0.846 ± 0.413
3.383PheAsp: 3.383 ± 1.037
1.691PheGlu: 1.691 ± 0.947
0.846PhePhe: 0.846 ± 0.413
1.268PheGly: 1.268 ± 0.62
0.423PheHis: 0.423 ± 0.207
2.96PheIle: 2.96 ± 1.447
2.114PheLys: 2.114 ± 1.456
1.691PheLeu: 1.691 ± 0.827
0.0PheMet: 0.0 ± 0.0
1.691PheAsn: 1.691 ± 0.827
0.423PhePro: 0.423 ± 0.207
2.114PheGln: 2.114 ± 1.034
1.268PheArg: 1.268 ± 0.62
2.114PheSer: 2.114 ± 1.034
2.537PheThr: 2.537 ± 0.909
0.846PheVal: 0.846 ± 1.104
0.0PheTrp: 0.0 ± 0.0
0.846PheTyr: 0.846 ± 0.413
0.0PheXaa: 0.0 ± 0.0
Gly
2.537GlyAla: 2.537 ± 0.909
1.268GlyCys: 1.268 ± 0.62
1.268GlyAsp: 1.268 ± 0.62
4.651GlyGlu: 4.651 ± 2.274
2.114GlyPhe: 2.114 ± 0.84
2.537GlyGly: 2.537 ± 1.962
1.691GlyHis: 1.691 ± 0.827
4.651GlyIle: 4.651 ± 1.668
3.805GlyLys: 3.805 ± 2.121
4.651GlyLeu: 4.651 ± 1.413
1.268GlyMet: 1.268 ± 0.62
3.805GlyAsn: 3.805 ± 1.128
3.383GlyPro: 3.383 ± 3.057
0.846GlyGln: 0.846 ± 0.413
2.96GlyArg: 2.96 ± 1.447
2.114GlySer: 2.114 ± 0.921
4.651GlyThr: 4.651 ± 1.413
4.228GlyVal: 4.228 ± 2.067
0.846GlyTrp: 0.846 ± 0.413
2.537GlyTyr: 2.537 ± 1.24
0.0GlyXaa: 0.0 ± 0.0
His
1.691HisAla: 1.691 ± 0.978
0.846HisCys: 0.846 ± 0.413
1.268HisAsp: 1.268 ± 0.62
0.846HisGlu: 0.846 ± 1.104
0.846HisPhe: 0.846 ± 0.413
1.268HisGly: 1.268 ± 0.62
0.423HisHis: 0.423 ± 0.207
2.114HisIle: 2.114 ± 1.034
1.691HisLys: 1.691 ± 0.827
2.96HisLeu: 2.96 ± 1.155
0.0HisMet: 0.0 ± 0.0
1.691HisAsn: 1.691 ± 1.617
0.423HisPro: 0.423 ± 0.207
1.691HisGln: 1.691 ± 0.978
1.268HisArg: 1.268 ± 0.62
1.268HisSer: 1.268 ± 0.981
0.0HisThr: 0.0 ± 0.0
1.268HisVal: 1.268 ± 0.62
0.0HisTrp: 0.0 ± 0.0
1.268HisTyr: 1.268 ± 1.072
0.0HisXaa: 0.0 ± 0.0
Ile
2.96IleAla: 2.96 ± 1.155
1.691IleCys: 1.691 ± 0.947
4.228IleAsp: 4.228 ± 2.067
6.342IleGlu: 6.342 ± 2.759
1.268IlePhe: 1.268 ± 0.62
2.537IleGly: 2.537 ± 1.24
2.96IleHis: 2.96 ± 1.447
5.497IleIle: 5.497 ± 1.76
5.92IleLys: 5.92 ± 1.755
5.497IleLeu: 5.497 ± 1.937
1.268IleMet: 1.268 ± 1.072
3.383IleAsn: 3.383 ± 2.281
3.805IlePro: 3.805 ± 1.86
6.765IleGln: 6.765 ± 2.53
2.96IleArg: 2.96 ± 1.447
6.342IleSer: 6.342 ± 1.548
2.537IleThr: 2.537 ± 1.24
2.96IleVal: 2.96 ± 1.447
0.0IleTrp: 0.0 ± 0.0
0.846IleTyr: 0.846 ± 0.413
0.0IleXaa: 0.0 ± 0.0
Lys
2.114LysAla: 2.114 ± 1.534
0.423LysCys: 0.423 ± 0.207
4.228LysAsp: 4.228 ± 1.969
8.457LysGlu: 8.457 ± 4.866
2.114LysPhe: 2.114 ± 1.034
3.383LysGly: 3.383 ± 1.654
2.114LysHis: 2.114 ± 0.921
5.497LysIle: 5.497 ± 2.48
5.074LysLys: 5.074 ± 1.581
8.457LysLeu: 8.457 ± 5.177
2.96LysMet: 2.96 ± 1.447
6.342LysAsn: 6.342 ± 2.953
4.651LysPro: 4.651 ± 3.119
1.691LysGln: 1.691 ± 0.89
4.651LysArg: 4.651 ± 1.668
5.497LysSer: 5.497 ± 0.64
1.268LysThr: 1.268 ± 0.62
6.765LysVal: 6.765 ± 2.818
0.423LysTrp: 0.423 ± 0.207
3.383LysTyr: 3.383 ± 1.654
0.0LysXaa: 0.0 ± 0.0
Leu
4.228LeuAla: 4.228 ± 2.939
1.691LeuCys: 1.691 ± 0.978
3.805LeuAsp: 3.805 ± 1.461
11.839LeuGlu: 11.839 ± 6.399
1.268LeuPhe: 1.268 ± 0.62
6.765LeuGly: 6.765 ± 2.325
1.691LeuHis: 1.691 ± 1.712
3.805LeuIle: 3.805 ± 0.998
8.879LeuLys: 8.879 ± 2.642
3.383LeuLeu: 3.383 ± 1.893
2.114LeuMet: 2.114 ± 2.213
1.691LeuAsn: 1.691 ± 0.827
4.228LeuPro: 4.228 ± 2.067
3.805LeuGln: 3.805 ± 1.718
4.651LeuArg: 4.651 ± 1.049
5.92LeuSer: 5.92 ± 4.03
4.651LeuThr: 4.651 ± 1.049
9.302LeuVal: 9.302 ± 2.581
0.423LeuTrp: 0.423 ± 0.207
1.691LeuTyr: 1.691 ± 0.827
0.0LeuXaa: 0.0 ± 0.0
Met
2.114MetAla: 2.114 ± 2.26
0.0MetCys: 0.0 ± 0.0
1.268MetAsp: 1.268 ± 1.072
3.383MetGlu: 3.383 ± 1.019
0.846MetPhe: 0.846 ± 0.413
0.846MetGly: 0.846 ± 0.413
1.268MetHis: 1.268 ± 0.62
2.114MetIle: 2.114 ± 0.933
2.537MetLys: 2.537 ± 1.24
0.846MetLeu: 0.846 ± 0.413
1.268MetMet: 1.268 ± 1.072
1.268MetAsn: 1.268 ± 0.62
0.846MetPro: 0.846 ± 0.413
0.423MetGln: 0.423 ± 0.207
0.846MetArg: 0.846 ± 0.413
1.268MetSer: 1.268 ± 1.787
2.114MetThr: 2.114 ± 1.034
0.846MetVal: 0.846 ± 0.413
0.0MetTrp: 0.0 ± 0.0
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
2.537AsnAla: 2.537 ± 0.909
0.846AsnCys: 0.846 ± 0.413
2.96AsnAsp: 2.96 ± 1.447
1.268AsnGlu: 1.268 ± 0.62
1.268AsnPhe: 1.268 ± 1.003
1.268AsnGly: 1.268 ± 0.62
1.268AsnHis: 1.268 ± 1.896
2.114AsnIle: 2.114 ± 0.933
4.651AsnLys: 4.651 ± 2.274
5.92AsnLeu: 5.92 ± 1.831
0.846AsnMet: 0.846 ± 0.384
0.423AsnAsn: 0.423 ± 1.249
1.691AsnPro: 1.691 ± 0.827
2.96AsnGln: 2.96 ± 0.943
2.114AsnArg: 2.114 ± 1.456
5.92AsnSer: 5.92 ± 1.945
5.074AsnThr: 5.074 ± 2.982
1.268AsnVal: 1.268 ± 0.62
0.423AsnTrp: 0.423 ± 0.207
2.114AsnTyr: 2.114 ± 0.921
0.0AsnXaa: 0.0 ± 0.0
Pro
3.383ProAla: 3.383 ± 0.981
0.0ProCys: 0.0 ± 0.0
1.691ProAsp: 1.691 ± 0.978
5.92ProGlu: 5.92 ± 0.999
0.846ProPhe: 0.846 ± 0.413
3.383ProGly: 3.383 ± 0.981
0.846ProHis: 0.846 ± 0.413
1.691ProIle: 1.691 ± 0.827
2.96ProLys: 2.96 ± 2.383
2.96ProLeu: 2.96 ± 1.177
2.537ProMet: 2.537 ± 0.909
2.96ProAsn: 2.96 ± 1.206
2.537ProPro: 2.537 ± 0.84
2.114ProGln: 2.114 ± 0.84
1.268ProArg: 1.268 ± 0.981
4.228ProSer: 4.228 ± 0.864
2.114ProThr: 2.114 ± 1.034
2.114ProVal: 2.114 ± 1.034
0.0ProTrp: 0.0 ± 0.0
1.691ProTyr: 1.691 ± 0.827
0.0ProXaa: 0.0 ± 0.0
Gln
4.651GlnAla: 4.651 ± 1.668
0.846GlnCys: 0.846 ± 0.413
3.805GlnAsp: 3.805 ± 2.249
4.228GlnGlu: 4.228 ± 2.067
0.423GlnPhe: 0.423 ± 0.207
3.383GlnGly: 3.383 ± 0.981
2.114GlnHis: 2.114 ± 1.034
2.114GlnIle: 2.114 ± 0.921
3.383GlnLys: 3.383 ± 1.072
7.188GlnLeu: 7.188 ± 6.679
1.268GlnMet: 1.268 ± 0.62
1.691GlnAsn: 1.691 ± 0.89
1.691GlnPro: 1.691 ± 1.621
6.342GlnGln: 6.342 ± 1.563
2.537GlnArg: 2.537 ± 1.24
2.114GlnSer: 2.114 ± 1.534
0.0GlnThr: 0.0 ± 0.0
2.96GlnVal: 2.96 ± 1.447
1.691GlnTrp: 1.691 ± 0.827
1.691GlnTyr: 1.691 ± 0.978
0.0GlnXaa: 0.0 ± 0.0
Arg
2.537ArgAla: 2.537 ± 0.909
0.0ArgCys: 0.0 ± 0.0
2.537ArgAsp: 2.537 ± 0.84
1.268ArgGlu: 1.268 ± 1.896
1.691ArgPhe: 1.691 ± 2.389
2.114ArgGly: 2.114 ± 0.84
0.423ArgHis: 0.423 ± 0.207
4.228ArgIle: 4.228 ± 1.425
3.805ArgLys: 3.805 ± 2.71
7.611ArgLeu: 7.611 ± 1.195
1.691ArgMet: 1.691 ± 0.827
1.691ArgAsn: 1.691 ± 0.827
2.114ArgPro: 2.114 ± 1.034
3.805ArgGln: 3.805 ± 0.948
2.537ArgArg: 2.537 ± 1.24
3.805ArgSer: 3.805 ± 0.948
4.228ArgThr: 4.228 ± 1.93
2.96ArgVal: 2.96 ± 1.447
1.691ArgTrp: 1.691 ± 0.827
0.423ArgTyr: 0.423 ± 0.207
0.0ArgXaa: 0.0 ± 0.0
Ser
3.383SerAla: 3.383 ± 1.779
0.423SerCys: 0.423 ± 0.207
1.268SerAsp: 1.268 ± 0.62
4.651SerGlu: 4.651 ± 2.882
0.846SerPhe: 0.846 ± 0.413
4.228SerGly: 4.228 ± 2.101
0.846SerHis: 0.846 ± 0.413
4.651SerIle: 4.651 ± 0.973
6.765SerLys: 6.765 ± 2.69
4.651SerLeu: 4.651 ± 1.587
0.846SerMet: 0.846 ± 0.413
1.691SerAsn: 1.691 ± 0.827
3.383SerPro: 3.383 ± 1.019
2.96SerGln: 2.96 ± 1.155
3.805SerArg: 3.805 ± 2.785
5.074SerSer: 5.074 ± 2.933
7.188SerThr: 7.188 ± 1.388
4.651SerVal: 4.651 ± 2.395
0.846SerTrp: 0.846 ± 0.413
0.846SerTyr: 0.846 ± 1.104
0.0SerXaa: 0.0 ± 0.0
Thr
3.383ThrAla: 3.383 ± 2.243
2.537ThrCys: 2.537 ± 1.24
2.96ThrAsp: 2.96 ± 0.943
4.651ThrGlu: 4.651 ± 1.049
1.691ThrPhe: 1.691 ± 0.827
4.651ThrGly: 4.651 ± 0.825
1.268ThrHis: 1.268 ± 0.62
3.805ThrIle: 3.805 ± 2.114
5.074ThrLys: 5.074 ± 2.125
2.96ThrLeu: 2.96 ± 3.732
1.268ThrMet: 1.268 ± 0.62
2.114ThrAsn: 2.114 ± 1.034
3.805ThrPro: 3.805 ± 1.128
2.114ThrGln: 2.114 ± 1.034
2.537ThrArg: 2.537 ± 2.144
3.805ThrSer: 3.805 ± 0.947
3.805ThrThr: 3.805 ± 1.86
1.691ThrVal: 1.691 ± 0.827
0.423ThrTrp: 0.423 ± 0.207
1.691ThrTyr: 1.691 ± 0.827
0.0ThrXaa: 0.0 ± 0.0
Val
3.383ValAla: 3.383 ± 1.019
1.691ValCys: 1.691 ± 0.947
2.96ValAsp: 2.96 ± 1.206
2.114ValGlu: 2.114 ± 0.933
5.497ValPhe: 5.497 ± 1.754
2.114ValGly: 2.114 ± 1.034
0.846ValHis: 0.846 ± 0.413
5.497ValIle: 5.497 ± 1.75
3.383ValLys: 3.383 ± 0.981
3.383ValLeu: 3.383 ± 1.019
0.846ValMet: 0.846 ± 0.413
3.805ValAsn: 3.805 ± 1.128
3.383ValPro: 3.383 ± 1.019
0.423ValGln: 0.423 ± 0.207
5.497ValArg: 5.497 ± 1.75
2.114ValSer: 2.114 ± 0.933
7.188ValThr: 7.188 ± 3.068
2.537ValVal: 2.537 ± 1.308
0.846ValTrp: 0.846 ± 0.413
1.268ValTyr: 1.268 ± 0.62
0.0ValXaa: 0.0 ± 0.0
Trp
0.0TrpAla: 0.0 ± 0.0
0.423TrpCys: 0.423 ± 0.207
0.846TrpAsp: 0.846 ± 0.413
0.423TrpGlu: 0.423 ± 0.207
0.0TrpPhe: 0.0 ± 0.0
0.846TrpGly: 0.846 ± 0.413
0.423TrpHis: 0.423 ± 0.207
1.268TrpIle: 1.268 ± 0.62
1.268TrpLys: 1.268 ± 0.62
1.268TrpLeu: 1.268 ± 0.62
0.846TrpMet: 0.846 ± 0.413
0.423TrpAsn: 0.423 ± 1.338
0.0TrpPro: 0.0 ± 0.0
1.691TrpGln: 1.691 ± 0.827
0.846TrpArg: 0.846 ± 0.413
0.0TrpSer: 0.0 ± 0.0
0.846TrpThr: 0.846 ± 0.413
0.423TrpVal: 0.423 ± 0.207
0.423TrpTrp: 0.423 ± 1.338
0.423TrpTyr: 0.423 ± 1.217
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.691TyrAla: 1.691 ± 0.827
0.423TyrCys: 0.423 ± 0.207
0.846TyrAsp: 0.846 ± 0.413
1.691TyrGlu: 1.691 ± 0.827
0.423TyrPhe: 0.423 ± 0.207
1.268TyrGly: 1.268 ± 1.072
1.268TyrHis: 1.268 ± 1.072
4.228TyrIle: 4.228 ± 1.249
2.114TyrLys: 2.114 ± 0.84
2.114TyrLeu: 2.114 ± 1.034
0.0TyrMet: 0.0 ± 0.0
1.691TyrAsn: 1.691 ± 0.827
1.268TyrPro: 1.268 ± 0.62
2.537TyrGln: 2.537 ± 2.144
1.268TyrArg: 1.268 ± 0.62
2.114TyrSer: 2.114 ± 0.933
0.846TyrThr: 0.846 ± 0.413
0.846TyrVal: 0.846 ± 0.413
0.846TyrTrp: 0.846 ± 0.413
1.268TyrTyr: 1.268 ± 1.072
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4 proteins (2366 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski