Amino acid dipepetide frequency for Glycocaulis profundi

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	21.465AlaAla: 21.465 ± 0.232	1.242AlaCys: 1.242 ± 0.038	8.366AlaAsp: 8.366 ± 0.096	9.585AlaGlu: 9.585 ± 0.12	5.025AlaPhe: 5.025 ± 0.072	12.836AlaGly: 12.836 ± 0.143	2.325AlaHis: 2.325 ± 0.052	5.726AlaIle: 5.726 ± 0.091	3.308AlaLys: 3.308 ± 0.086	15.704AlaLeu: 15.704 ± 0.167	3.67AlaMet: 3.67 ± 0.065	2.518AlaAsn: 2.518 ± 0.053	7.205AlaPro: 7.205 ± 0.099	3.818AlaGln: 3.818 ± 0.064	11.737AlaArg: 11.737 ± 0.139	6.725AlaSer: 6.725 ± 0.086	4.979AlaThr: 4.979 ± 0.08	9.425AlaVal: 9.425 ± 0.115	1.795AlaTrp: 1.795 ± 0.047	2.561AlaTyr: 2.561 ± 0.044	0.021AlaXaa: 0.021 ± 0.004
Cys	1.112CysAla: 1.112 ± 0.037	0.088CysCys: 0.088 ± 0.01	0.462CysAsp: 0.462 ± 0.023	0.49CysGlu: 0.49 ± 0.026	0.276CysPhe: 0.276 ± 0.017	0.861CysGly: 0.861 ± 0.031	0.179CysHis: 0.179 ± 0.013	0.246CysIle: 0.246 ± 0.016	0.147CysLys: 0.147 ± 0.012	0.728CysLeu: 0.728 ± 0.03	0.126CysMet: 0.126 ± 0.012	0.145CysAsn: 0.145 ± 0.012	0.481CysPro: 0.481 ± 0.023	0.188CysGln: 0.188 ± 0.013	0.532CysArg: 0.532 ± 0.024	0.378CysSer: 0.378 ± 0.018	0.309CysThr: 0.309 ± 0.018	0.539CysVal: 0.539 ± 0.023	0.098CysTrp: 0.098 ± 0.01	0.136CysTyr: 0.136 ± 0.012	0.003CysXaa: 0.003 ± 0.002
Asp	8.66AspAla: 8.66 ± 0.102	0.44AspCys: 0.44 ± 0.024	3.589AspAsp: 3.589 ± 0.071	4.021AspGlu: 4.021 ± 0.062	2.38AspPhe: 2.38 ± 0.054	6.399AspGly: 6.399 ± 0.094	1.389AspHis: 1.389 ± 0.046	2.728AspIle: 2.728 ± 0.056	1.115AspLys: 1.115 ± 0.04	5.997AspLeu: 5.997 ± 0.079	1.413AspMet: 1.413 ± 0.033	1.097AspAsn: 1.097 ± 0.037	4.405AspPro: 4.405 ± 0.056	1.722AspGln: 1.722 ± 0.044	5.004AspArg: 5.004 ± 0.072	2.261AspSer: 2.261 ± 0.045	2.715AspThr: 2.715 ± 0.047	4.093AspVal: 4.093 ± 0.071	1.129AspTrp: 1.129 ± 0.035	1.547AspTyr: 1.547 ± 0.043	0.02AspXaa: 0.02 ± 0.005
Glu	10.4GluAla: 10.4 ± 0.141	0.306GluCys: 0.306 ± 0.018	3.992GluAsp: 3.992 ± 0.066	3.575GluGlu: 3.575 ± 0.078	1.866GluPhe: 1.866 ± 0.043	5.851GluGly: 5.851 ± 0.076	1.226GluHis: 1.226 ± 0.039	3.537GluIle: 3.537 ± 0.064	1.818GluLys: 1.818 ± 0.053	5.491GluLeu: 5.491 ± 0.077	1.586GluMet: 1.586 ± 0.04	1.536GluAsn: 1.536 ± 0.038	3.575GluPro: 3.575 ± 0.062	1.894GluGln: 1.894 ± 0.044	6.151GluArg: 6.151 ± 0.095	2.534GluSer: 2.534 ± 0.05	4.37GluThr: 4.37 ± 0.068	3.756GluVal: 3.756 ± 0.058	0.789GluTrp: 0.789 ± 0.027	1.128GluTyr: 1.128 ± 0.033	0.022GluXaa: 0.022 ± 0.006
Phe	4.949PheAla: 4.949 ± 0.08	0.299PheCys: 0.299 ± 0.018	2.826PheAsp: 2.826 ± 0.054	2.594PheGlu: 2.594 ± 0.048	1.397PhePhe: 1.397 ± 0.041	3.509PheGly: 3.509 ± 0.06	0.753PheHis: 0.753 ± 0.029	1.718PheIle: 1.718 ± 0.042	0.783PheLys: 0.783 ± 0.029	3.126PheLeu: 3.126 ± 0.061	0.873PheMet: 0.873 ± 0.031	1.043PheAsn: 1.043 ± 0.033	1.517PhePro: 1.517 ± 0.037	0.931PheGln: 0.931 ± 0.029	2.259PheArg: 2.259 ± 0.044	2.213PheSer: 2.213 ± 0.051	2.141PheThr: 2.141 ± 0.051	2.334PheVal: 2.334 ± 0.056	0.5PheTrp: 0.5 ± 0.024	0.875PheTyr: 0.875 ± 0.029	0.009PheXaa: 0.009 ± 0.003
Gly	11.994GlyAla: 11.994 ± 0.134	0.714GlyCys: 0.714 ± 0.027	4.981GlyAsp: 4.981 ± 0.079	6.632GlyGlu: 6.632 ± 0.102	3.892GlyPhe: 3.892 ± 0.064	8.682GlyGly: 8.682 ± 0.114	1.854GlyHis: 1.854 ± 0.043	3.532GlyIle: 3.532 ± 0.064	2.177GlyLys: 2.177 ± 0.061	9.368GlyLeu: 9.368 ± 0.113	2.306GlyMet: 2.306 ± 0.055	1.683GlyAsn: 1.683 ± 0.051	4.517GlyPro: 4.517 ± 0.076	2.838GlyGln: 2.838 ± 0.064	7.635GlyArg: 7.635 ± 0.093	4.482GlySer: 4.482 ± 0.074	3.696GlyThr: 3.696 ± 0.071	6.702GlyVal: 6.702 ± 0.083	1.693GlyTrp: 1.693 ± 0.045	2.181GlyTyr: 2.181 ± 0.045	0.044GlyXaa: 0.044 ± 0.012
His	2.573HisAla: 2.573 ± 0.056	0.184HisCys: 0.184 ± 0.011	1.262HisAsp: 1.262 ± 0.045	1.213HisGlu: 1.213 ± 0.037	0.708HisPhe: 0.708 ± 0.025	1.937HisGly: 1.937 ± 0.045	0.534HisHis: 0.534 ± 0.027	0.71HisIle: 0.71 ± 0.026	0.35HisLys: 0.35 ± 0.016	1.758HisLeu: 1.758 ± 0.046	0.405HisMet: 0.405 ± 0.021	0.372HisAsn: 0.372 ± 0.017	1.306HisPro: 1.306 ± 0.037	0.563HisGln: 0.563 ± 0.025	1.428HisArg: 1.428 ± 0.038	0.739HisSer: 0.739 ± 0.031	0.718HisThr: 0.718 ± 0.027	1.466HisVal: 1.466 ± 0.042	0.278HisTrp: 0.278 ± 0.016	0.468HisTyr: 0.468 ± 0.02	0.002HisXaa: 0.002 ± 0.001
Ile	7.17IleAla: 7.17 ± 0.102	0.398IleCys: 0.398 ± 0.02	3.237IleAsp: 3.237 ± 0.062	3.706IleGlu: 3.706 ± 0.073	1.434IlePhe: 1.434 ± 0.037	4.326IleGly: 4.326 ± 0.082	0.871IleHis: 0.871 ± 0.028	1.836IleIle: 1.836 ± 0.053	1.086IleLys: 1.086 ± 0.039	3.818IleLeu: 3.818 ± 0.064	0.819IleMet: 0.819 ± 0.03	1.129IleAsn: 1.129 ± 0.036	2.078IlePro: 2.078 ± 0.043	1.144IleGln: 1.144 ± 0.031	3.102IleArg: 3.102 ± 0.063	2.457IleSer: 2.457 ± 0.052	2.414IleThr: 2.414 ± 0.057	3.339IleVal: 3.339 ± 0.072	0.532IleTrp: 0.532 ± 0.025	0.851IleTyr: 0.851 ± 0.028	0.012IleXaa: 0.012 ± 0.004
Lys	3.847LysAla: 3.847 ± 0.088	0.123LysCys: 0.123 ± 0.012	1.456LysAsp: 1.456 ± 0.044	1.203LysGlu: 1.203 ± 0.046	0.674LysPhe: 0.674 ± 0.028	2.126LysGly: 2.126 ± 0.057	0.432LysHis: 0.432 ± 0.02	1.215LysIle: 1.215 ± 0.038	1.132LysLys: 1.132 ± 0.054	2.129LysLeu: 2.129 ± 0.054	0.565LysMet: 0.565 ± 0.028	0.586LysAsn: 0.586 ± 0.028	1.581LysPro: 1.581 ± 0.047	0.636LysGln: 0.636 ± 0.027	1.901LysArg: 1.901 ± 0.051	1.403LysSer: 1.403 ± 0.038	1.635LysThr: 1.635 ± 0.046	1.685LysVal: 1.685 ± 0.044	0.27LysTrp: 0.27 ± 0.015	0.481LysTyr: 0.481 ± 0.024	0.019LysXaa: 0.019 ± 0.005
Leu	13.977LeuAla: 13.977 ± 0.144	0.762LeuCys: 0.762 ± 0.025	6.746LeuAsp: 6.746 ± 0.086	5.998LeuGlu: 5.998 ± 0.084	3.3LeuPhe: 3.3 ± 0.064	8.016LeuGly: 8.016 ± 0.096	1.828LeuHis: 1.828 ± 0.048	5.1LeuIle: 5.1 ± 0.081	3.162LeuLys: 3.162 ± 0.074	7.809LeuLeu: 7.809 ± 0.104	2.265LeuMet: 2.265 ± 0.052	2.431LeuAsn: 2.431 ± 0.054	5.101LeuPro: 5.101 ± 0.076	2.391LeuGln: 2.391 ± 0.052	6.491LeuArg: 6.491 ± 0.092	6.261LeuSer: 6.261 ± 0.084	5.288LeuThr: 5.288 ± 0.077	6.513LeuVal: 6.513 ± 0.094	1.112LeuTrp: 1.112 ± 0.038	1.942LeuTyr: 1.942 ± 0.039	0.02LeuXaa: 0.02 ± 0.004
Met	3.489MetAla: 3.489 ± 0.062	0.126MetCys: 0.126 ± 0.011	1.34MetAsp: 1.34 ± 0.032	1.301MetGlu: 1.301 ± 0.03	0.654MetPhe: 0.654 ± 0.023	1.969MetGly: 1.969 ± 0.043	0.334MetHis: 0.334 ± 0.018	1.292MetIle: 1.292 ± 0.036	0.895MetLys: 0.895 ± 0.029	2.108MetLeu: 2.108 ± 0.046	0.612MetMet: 0.612 ± 0.028	0.675MetAsn: 0.675 ± 0.026	1.228MetPro: 1.228 ± 0.038	0.581MetGln: 0.581 ± 0.024	1.836MetArg: 1.836 ± 0.041	1.571MetSer: 1.571 ± 0.04	1.927MetThr: 1.927 ± 0.046	1.517MetVal: 1.517 ± 0.037	0.215MetTrp: 0.215 ± 0.014	0.249MetTyr: 0.249 ± 0.017	0.004MetXaa: 0.004 ± 0.002
Asn	2.955AsnAla: 2.955 ± 0.054	0.184AsnCys: 0.184 ± 0.014	1.17AsnAsp: 1.17 ± 0.038	1.124AsnGlu: 1.124 ± 0.038	0.871AsnPhe: 0.871 ± 0.036	1.925AsnGly: 1.925 ± 0.048	0.427AsnHis: 0.427 ± 0.019	1.087AsnIle: 1.087 ± 0.034	0.472AsnLys: 0.472 ± 0.024	2.194AsnLeu: 2.194 ± 0.055	0.506AsnMet: 0.506 ± 0.024	0.616AsnAsn: 0.616 ± 0.027	1.717AsnPro: 1.717 ± 0.041	0.644AsnGln: 0.644 ± 0.031	1.58AsnArg: 1.58 ± 0.041	0.991AsnSer: 0.991 ± 0.036	1.13AsnThr: 1.13 ± 0.033	1.622AsnVal: 1.622 ± 0.041	0.355AsnTrp: 0.355 ± 0.018	0.628AsnTyr: 0.628 ± 0.031	0.006AsnXaa: 0.006 ± 0.002
Pro	7.397ProAla: 7.397 ± 0.098	0.367ProCys: 0.367 ± 0.018	4.444ProAsp: 4.444 ± 0.076	4.654ProGlu: 4.654 ± 0.081	1.937ProPhe: 1.937 ± 0.044	5.809ProGly: 5.809 ± 0.111	0.945ProHis: 0.945 ± 0.031	1.841ProIle: 1.841 ± 0.041	1.296ProLys: 1.296 ± 0.046	4.7ProLeu: 4.7 ± 0.069	1.198ProMet: 1.198 ± 0.033	1.055ProAsn: 1.055 ± 0.04	2.94ProPro: 2.94 ± 0.076	1.393ProGln: 1.393 ± 0.038	3.437ProArg: 3.437 ± 0.059	2.734ProSer: 2.734 ± 0.051	1.767ProThr: 1.767 ± 0.041	4.431ProVal: 4.431 ± 0.058	0.681ProTrp: 0.681 ± 0.026	1.055ProTyr: 1.055 ± 0.029	0.022ProXaa: 0.022 ± 0.006
Gln	4.197GlnAla: 4.197 ± 0.069	0.175GlnCys: 0.175 ± 0.013	1.47GlnAsp: 1.47 ± 0.039	1.37GlnGlu: 1.37 ± 0.037	0.909GlnPhe: 0.909 ± 0.032	2.403GlnGly: 2.403 ± 0.05	0.464GlnHis: 0.464 ± 0.021	1.564GlnIle: 1.564 ± 0.037	0.646GlnLys: 0.646 ± 0.029	2.348GlnLeu: 2.348 ± 0.054	0.737GlnMet: 0.737 ± 0.026	0.651GlnAsn: 0.651 ± 0.027	1.621GlnPro: 1.621 ± 0.041	0.83GlnGln: 0.83 ± 0.034	2.131GlnArg: 2.131 ± 0.05	1.55GlnSer: 1.55 ± 0.037	1.796GlnThr: 1.796 ± 0.046	2.038GlnVal: 2.038 ± 0.045	0.363GlnTrp: 0.363 ± 0.019	0.482GlnTyr: 0.482 ± 0.023	0.009GlnXaa: 0.009 ± 0.003
Arg	10.231ArgAla: 10.231 ± 0.124	0.484ArgCys: 0.484 ± 0.022	4.456ArgAsp: 4.456 ± 0.072	5.119ArgGlu: 5.119 ± 0.077	3.334ArgPhe: 3.334 ± 0.063	5.625ArgGly: 5.625 ± 0.08	1.665ArgHis: 1.665 ± 0.042	3.936ArgIle: 3.936 ± 0.054	1.776ArgLys: 1.776 ± 0.05	8.784ArgLeu: 8.784 ± 0.102	1.987ArgMet: 1.987 ± 0.049	1.56ArgAsn: 1.56 ± 0.039	4.225ArgPro: 4.225 ± 0.073	2.466ArgGln: 2.466 ± 0.057	6.683ArgArg: 6.683 ± 0.103	3.685ArgSer: 3.685 ± 0.058	3.565ArgThr: 3.565 ± 0.06	5.085ArgVal: 5.085 ± 0.075	1.248ArgTrp: 1.248 ± 0.034	1.763ArgTyr: 1.763 ± 0.043	0.018ArgXaa: 0.018 ± 0.004
Ser	6.907SerAla: 6.907 ± 0.093	0.352SerCys: 0.352 ± 0.019	3.237SerAsp: 3.237 ± 0.063	3.15SerGlu: 3.15 ± 0.063	1.935SerPhe: 1.935 ± 0.038	5.737SerGly: 5.737 ± 0.083	0.934SerHis: 0.934 ± 0.032	2.171SerIle: 2.171 ± 0.049	1.264SerLys: 1.264 ± 0.036	4.88SerLeu: 4.88 ± 0.071	1.268SerMet: 1.268 ± 0.04	1.202SerAsn: 1.202 ± 0.038	2.838SerPro: 2.838 ± 0.054	1.504SerGln: 1.504 ± 0.04	3.712SerArg: 3.712 ± 0.059	2.598SerSer: 2.598 ± 0.052	2.108SerThr: 2.108 ± 0.05	3.654SerVal: 3.654 ± 0.054	0.783SerTrp: 0.783 ± 0.029	1.132SerTyr: 1.132 ± 0.036	0.014SerXaa: 0.014 ± 0.004
Thr	6.465ThrAla: 6.465 ± 0.08	0.349ThrCys: 0.349 ± 0.019	2.872ThrAsp: 2.872 ± 0.068	2.885ThrGlu: 2.885 ± 0.055	1.653ThrPhe: 1.653 ± 0.047	5.616ThrGly: 5.616 ± 0.076	0.854ThrHis: 0.854 ± 0.029	2.075ThrIle: 2.075 ± 0.05	0.949ThrLys: 0.949 ± 0.033	5.401ThrLeu: 5.401 ± 0.081	0.952ThrMet: 0.952 ± 0.031	1.095ThrAsn: 1.095 ± 0.033	3.117ThrPro: 3.117 ± 0.056	1.198ThrGln: 1.198 ± 0.035	3.323ThrArg: 3.323 ± 0.05	2.22ThrSer: 2.22 ± 0.044	2.127ThrThr: 2.127 ± 0.052	4.078ThrVal: 4.078 ± 0.065	0.571ThrTrp: 0.571 ± 0.025	0.99ThrTyr: 0.99 ± 0.033	0.014ThrXaa: 0.014 ± 0.004
Val	7.98ValAla: 7.98 ± 0.107	0.654ValCys: 0.654 ± 0.022	3.963ValAsp: 3.963 ± 0.061	4.666ValGlu: 4.666 ± 0.072	3.067ValPhe: 3.067 ± 0.057	4.868ValGly: 4.868 ± 0.073	1.28ValHis: 1.28 ± 0.033	4.017ValIle: 4.017 ± 0.075	1.896ValLys: 1.896 ± 0.049	6.654ValLeu: 6.654 ± 0.077	1.824ValMet: 1.824 ± 0.044	1.852ValAsn: 1.852 ± 0.046	3.059ValPro: 3.059 ± 0.055	1.962ValGln: 1.962 ± 0.043	5.483ValArg: 5.483 ± 0.077	4.624ValSer: 4.624 ± 0.068	4.114ValThr: 4.114 ± 0.069	4.804ValVal: 4.804 ± 0.081	1.154ValTrp: 1.154 ± 0.03	1.438ValTyr: 1.438 ± 0.039	0.019ValXaa: 0.019 ± 0.005
Trp	1.551TrpAla: 1.551 ± 0.044	0.103TrpCys: 0.103 ± 0.01	0.741TrpAsp: 0.741 ± 0.032	0.681TrpGlu: 0.681 ± 0.025	0.555TrpPhe: 0.555 ± 0.022	0.979TrpGly: 0.979 ± 0.03	0.259TrpHis: 0.259 ± 0.019	0.712TrpIle: 0.712 ± 0.028	0.356TrpLys: 0.356 ± 0.018	1.616TrpLeu: 1.616 ± 0.044	0.397TrpMet: 0.397 ± 0.021	0.395TrpAsn: 0.395 ± 0.021	0.683TrpPro: 0.683 ± 0.027	0.404TrpGln: 0.404 ± 0.02	1.595TrpArg: 1.595 ± 0.038	0.845TrpSer: 0.845 ± 0.029	1.02TrpThr: 1.02 ± 0.034	0.756TrpVal: 0.756 ± 0.029	0.241TrpTrp: 0.241 ± 0.014	0.244TrpTyr: 0.244 ± 0.018	0.005TrpXaa: 0.005 ± 0.002
Tyr	2.695TyrAla: 2.695 ± 0.048	0.172TyrCys: 0.172 ± 0.012	1.493TyrAsp: 1.493 ± 0.049	1.417TyrGlu: 1.417 ± 0.039	0.775TyrPhe: 0.775 ± 0.028	2.087TyrGly: 2.087 ± 0.048	0.414TyrHis: 0.414 ± 0.019	0.712TyrIle: 0.712 ± 0.027	0.453TyrLys: 0.453 ± 0.022	1.884TyrLeu: 1.884 ± 0.041	0.407TyrMet: 0.407 ± 0.021	0.551TyrAsn: 0.551 ± 0.027	0.885TyrPro: 0.885 ± 0.032	0.636TyrGln: 0.636 ± 0.024	1.659TyrArg: 1.659 ± 0.041	1.089TyrSer: 1.089 ± 0.036	0.967TyrThr: 0.967 ± 0.038	1.519TyrVal: 1.519 ± 0.042	0.33TyrTrp: 0.33 ± 0.019	0.478TyrTyr: 0.478 ± 0.024	0.007TyrXaa: 0.007 ± 0.003
Xaa	0.02XaaAla: 0.02 ± 0.006	0.004XaaCys: 0.004 ± 0.002	0.02XaaAsp: 0.02 ± 0.005	0.02XaaGlu: 0.02 ± 0.005	0.007XaaPhe: 0.007 ± 0.003	0.04XaaGly: 0.04 ± 0.01	0.005XaaHis: 0.005 ± 0.002	0.007XaaIle: 0.007 ± 0.003	0.017XaaLys: 0.017 ± 0.004	0.014XaaLeu: 0.014 ± 0.004	0.005XaaMet: 0.005 ± 0.002	0.01XaaAsn: 0.01 ± 0.004	0.026XaaPro: 0.026 ± 0.009	0.011XaaGln: 0.011 ± 0.003	0.016XaaArg: 0.016 ± 0.005	0.02XaaSer: 0.02 ± 0.006	0.018XaaThr: 0.018 ± 0.004	0.021XaaVal: 0.021 ± 0.006	0.003XaaTrp: 0.003 ± 0.002	0.003XaaTyr: 0.003 ± 0.002	0.021XaaXaa: 0.021 ± 0.005

Statistics based on 3419 proteins (1075312 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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