Amino acid dipepetide frequency for Lactobacillus coryniformis subsp. coryniformis CECT 5711

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
11.229AlaAla: 11.229 ± 0.201
0.444AlaCys: 0.444 ± 0.026
5.868AlaAsp: 5.868 ± 0.095
5.318AlaGlu: 5.318 ± 0.108
3.452AlaPhe: 3.452 ± 0.07
6.89AlaGly: 6.89 ± 0.102
1.946AlaHis: 1.946 ± 0.052
6.238AlaIle: 6.238 ± 0.116
5.654AlaLys: 5.654 ± 0.095
9.255AlaLeu: 9.255 ± 0.134
2.182AlaMet: 2.182 ± 0.058
3.943AlaAsn: 3.943 ± 0.078
3.049AlaPro: 3.049 ± 0.075
5.287AlaGln: 5.287 ± 0.124
3.484AlaArg: 3.484 ± 0.072
4.643AlaSer: 4.643 ± 0.102
6.579AlaThr: 6.579 ± 0.129
6.673AlaVal: 6.673 ± 0.112
0.838AlaTrp: 0.838 ± 0.039
2.855AlaTyr: 2.855 ± 0.064
0.0AlaXaa: 0.0 ± 0.0
Cys
0.418CysAla: 0.418 ± 0.024
0.063CysCys: 0.063 ± 0.011
0.273CysAsp: 0.273 ± 0.02
0.228CysGlu: 0.228 ± 0.018
0.222CysPhe: 0.222 ± 0.016
0.483CysGly: 0.483 ± 0.029
0.192CysHis: 0.192 ± 0.022
0.296CysIle: 0.296 ± 0.022
0.139CysLys: 0.139 ± 0.014
0.586CysLeu: 0.586 ± 0.029
0.097CysMet: 0.097 ± 0.012
0.171CysAsn: 0.171 ± 0.016
0.258CysPro: 0.258 ± 0.022
0.335CysGln: 0.335 ± 0.022
0.219CysArg: 0.219 ± 0.018
0.255CysSer: 0.255 ± 0.019
0.249CysThr: 0.249 ± 0.022
0.308CysVal: 0.308 ± 0.021
0.054CysTrp: 0.054 ± 0.01
0.19CysTyr: 0.19 ± 0.018
0.0CysXaa: 0.0 ± 0.0
Asp
4.279AspAla: 4.279 ± 0.083
0.275AspCys: 0.275 ± 0.021
3.005AspAsp: 3.005 ± 0.092
3.411AspGlu: 3.411 ± 0.084
2.881AspPhe: 2.881 ± 0.064
3.269AspGly: 3.269 ± 0.073
1.407AspHis: 1.407 ± 0.058
3.36AspIle: 3.36 ± 0.074
2.845AspLys: 2.845 ± 0.083
5.744AspLeu: 5.744 ± 0.105
1.317AspMet: 1.317 ± 0.039
2.105AspAsn: 2.105 ± 0.058
2.3AspPro: 2.3 ± 0.061
3.162AspGln: 3.162 ± 0.073
2.271AspArg: 2.271 ± 0.06
2.528AspSer: 2.528 ± 0.069
2.816AspThr: 2.816 ± 0.063
3.78AspVal: 3.78 ± 0.08
0.642AspTrp: 0.642 ± 0.038
2.582AspTyr: 2.582 ± 0.06
0.0AspXaa: 0.0 ± 0.0
Glu
4.435GluAla: 4.435 ± 0.093
0.196GluCys: 0.196 ± 0.018
2.209GluAsp: 2.209 ± 0.061
2.433GluGlu: 2.433 ± 0.083
2.116GluPhe: 2.116 ± 0.058
2.328GluGly: 2.328 ± 0.071
1.262GluHis: 1.262 ± 0.047
3.576GluIle: 3.576 ± 0.081
3.36GluLys: 3.36 ± 0.078
6.259GluLeu: 6.259 ± 0.114
1.54GluMet: 1.54 ± 0.051
2.251GluAsn: 2.251 ± 0.062
1.67GluPro: 1.67 ± 0.056
3.269GluGln: 3.269 ± 0.081
2.754GluArg: 2.754 ± 0.073
2.261GluSer: 2.261 ± 0.062
2.939GluThr: 2.939 ± 0.064
3.55GluVal: 3.55 ± 0.078
0.435GluTrp: 0.435 ± 0.029
1.522GluTyr: 1.522 ± 0.053
0.0GluXaa: 0.0 ± 0.0
Phe
3.858PheAla: 3.858 ± 0.083
0.252PheCys: 0.252 ± 0.019
2.531PheAsp: 2.531 ± 0.062
1.866PheGlu: 1.866 ± 0.057
1.812PhePhe: 1.812 ± 0.057
3.248PheGly: 3.248 ± 0.071
0.788PheHis: 0.788 ± 0.033
2.969PheIle: 2.969 ± 0.069
2.251PheLys: 2.251 ± 0.062
3.698PheLeu: 3.698 ± 0.1
1.116PheMet: 1.116 ± 0.044
1.965PheAsn: 1.965 ± 0.048
1.557PhePro: 1.557 ± 0.056
1.573PheGln: 1.573 ± 0.048
1.306PheArg: 1.306 ± 0.043
2.846PheSer: 2.846 ± 0.078
2.769PheThr: 2.769 ± 0.074
3.023PheVal: 3.023 ± 0.072
0.501PheTrp: 0.501 ± 0.031
1.613PheTyr: 1.613 ± 0.048
0.0PheXaa: 0.0 ± 0.0
Gly
5.666GlyAla: 5.666 ± 0.107
0.421GlyCys: 0.421 ± 0.027
3.334GlyAsp: 3.334 ± 0.077
3.197GlyGlu: 3.197 ± 0.071
3.05GlyPhe: 3.05 ± 0.078
4.63GlyGly: 4.63 ± 0.101
1.623GlyHis: 1.623 ± 0.047
5.287GlyIle: 5.287 ± 0.096
4.021GlyLys: 4.021 ± 0.084
6.982GlyLeu: 6.982 ± 0.114
1.892GlyMet: 1.892 ± 0.054
2.498GlyAsn: 2.498 ± 0.056
1.777GlyPro: 1.777 ± 0.06
3.33GlyGln: 3.33 ± 0.067
2.875GlyArg: 2.875 ± 0.078
3.62GlySer: 3.62 ± 0.089
4.399GlyThr: 4.399 ± 0.07
5.101GlyVal: 5.101 ± 0.1
0.723GlyTrp: 0.723 ± 0.034
2.801GlyTyr: 2.801 ± 0.065
0.0GlyXaa: 0.0 ± 0.0
His
1.569HisAla: 1.569 ± 0.052
0.145HisCys: 0.145 ± 0.015
1.308HisAsp: 1.308 ± 0.049
1.258HisGlu: 1.258 ± 0.043
1.146HisPhe: 1.146 ± 0.043
1.675HisGly: 1.675 ± 0.055
0.74HisHis: 0.74 ± 0.038
1.287HisIle: 1.287 ± 0.047
0.986HisLys: 0.986 ± 0.041
2.381HisLeu: 2.381 ± 0.064
0.536HisMet: 0.536 ± 0.03
0.942HisAsn: 0.942 ± 0.039
1.03HisPro: 1.03 ± 0.039
1.314HisGln: 1.314 ± 0.043
0.88HisArg: 0.88 ± 0.038
1.13HisSer: 1.13 ± 0.037
1.137HisThr: 1.137 ± 0.035
1.459HisVal: 1.459 ± 0.044
0.304HisTrp: 0.304 ± 0.021
1.045HisTyr: 1.045 ± 0.039
0.0HisXaa: 0.0 ± 0.0
Ile
6.674IleAla: 6.674 ± 0.113
0.433IleCys: 0.433 ± 0.025
4.077IleAsp: 4.077 ± 0.089
3.517IleGlu: 3.517 ± 0.086
2.81IlePhe: 2.81 ± 0.08
5.29IleGly: 5.29 ± 0.108
1.274IleHis: 1.274 ± 0.042
4.524IleIle: 4.524 ± 0.102
3.852IleLys: 3.852 ± 0.071
6.211IleLeu: 6.211 ± 0.127
1.661IleMet: 1.661 ± 0.049
2.889IleAsn: 2.889 ± 0.068
2.691IlePro: 2.691 ± 0.068
2.528IleGln: 2.528 ± 0.061
2.614IleArg: 2.614 ± 0.066
4.011IleSer: 4.011 ± 0.071
4.449IleThr: 4.449 ± 0.087
4.858IleVal: 4.858 ± 0.091
0.538IleTrp: 0.538 ± 0.033
2.111IleTyr: 2.111 ± 0.063
0.0IleXaa: 0.0 ± 0.0
Lys
4.941LysAla: 4.941 ± 0.103
0.136LysCys: 0.136 ± 0.014
2.618LysAsp: 2.618 ± 0.075
2.768LysGlu: 2.768 ± 0.072
1.705LysPhe: 1.705 ± 0.048
2.952LysGly: 2.952 ± 0.081
1.104LysHis: 1.104 ± 0.041
3.811LysIle: 3.811 ± 0.084
3.591LysLys: 3.591 ± 0.099
5.389LysLeu: 5.389 ± 0.083
1.888LysMet: 1.888 ± 0.051
2.483LysAsn: 2.483 ± 0.065
2.036LysPro: 2.036 ± 0.058
3.508LysGln: 3.508 ± 0.074
2.946LysArg: 2.946 ± 0.065
2.845LysSer: 2.845 ± 0.075
3.611LysThr: 3.611 ± 0.077
4.039LysVal: 4.039 ± 0.093
0.541LysTrp: 0.541 ± 0.032
1.904LysTyr: 1.904 ± 0.058
0.0LysXaa: 0.0 ± 0.0
Leu
11.487LeuAla: 11.487 ± 0.155
0.533LeuCys: 0.533 ± 0.03
5.415LeuAsp: 5.415 ± 0.09
4.369LeuGlu: 4.369 ± 0.09
4.246LeuPhe: 4.246 ± 0.093
6.887LeuGly: 6.887 ± 0.117
2.022LeuHis: 2.022 ± 0.06
6.765LeuIle: 6.765 ± 0.119
5.445LeuLys: 5.445 ± 0.09
10.628LeuLeu: 10.628 ± 0.177
2.402LeuMet: 2.402 ± 0.065
4.642LeuAsn: 4.642 ± 0.086
4.927LeuPro: 4.927 ± 0.085
4.976LeuGln: 4.976 ± 0.114
4.441LeuArg: 4.441 ± 0.082
6.22LeuSer: 6.22 ± 0.116
7.525LeuThr: 7.525 ± 0.114
7.168LeuVal: 7.168 ± 0.128
0.84LeuTrp: 0.84 ± 0.042
2.908LeuTyr: 2.908 ± 0.062
0.0LeuXaa: 0.0 ± 0.0
Met
2.579MetAla: 2.579 ± 0.056
0.122MetCys: 0.122 ± 0.014
1.145MetAsp: 1.145 ± 0.042
1.004MetGlu: 1.004 ± 0.043
0.793MetPhe: 0.793 ± 0.033
1.649MetGly: 1.649 ± 0.051
0.482MetHis: 0.482 ± 0.029
1.91MetIle: 1.91 ± 0.061
1.383MetLys: 1.383 ± 0.044
2.44MetLeu: 2.44 ± 0.064
0.74MetMet: 0.74 ± 0.039
1.113MetAsn: 1.113 ± 0.045
1.033MetPro: 1.033 ± 0.041
1.457MetGln: 1.457 ± 0.048
1.169MetArg: 1.169 ± 0.043
1.41MetSer: 1.41 ± 0.039
1.966MetThr: 1.966 ± 0.055
1.682MetVal: 1.682 ± 0.053
0.165MetTrp: 0.165 ± 0.018
0.545MetTyr: 0.545 ± 0.031
0.0MetXaa: 0.0 ± 0.0
Asn
3.372AsnAla: 3.372 ± 0.073
0.223AsnCys: 0.223 ± 0.018
2.328AsnAsp: 2.328 ± 0.063
2.31AsnGlu: 2.31 ± 0.061
1.786AsnPhe: 1.786 ± 0.055
3.136AsnGly: 3.136 ± 0.068
1.012AsnHis: 1.012 ± 0.041
2.591AsnIle: 2.591 ± 0.063
2.096AsnLys: 2.096 ± 0.064
4.166AsnLeu: 4.166 ± 0.086
1.027AsnMet: 1.027 ± 0.039
1.862AsnAsn: 1.862 ± 0.059
1.735AsnPro: 1.735 ± 0.054
2.553AsnGln: 2.553 ± 0.069
1.878AsnArg: 1.878 ± 0.064
2.174AsnSer: 2.174 ± 0.053
2.321AsnThr: 2.321 ± 0.063
2.963AsnVal: 2.963 ± 0.063
0.569AsnTrp: 0.569 ± 0.029
1.693AsnTyr: 1.693 ± 0.057
0.0AsnXaa: 0.0 ± 0.0
Pro
3.831ProAla: 3.831 ± 0.073
0.169ProCys: 0.169 ± 0.018
2.292ProAsp: 2.292 ± 0.064
2.857ProGlu: 2.857 ± 0.072
1.74ProPhe: 1.74 ± 0.061
2.316ProGly: 2.316 ± 0.064
0.817ProHis: 0.817 ± 0.035
2.461ProIle: 2.461 ± 0.06
2.007ProLys: 2.007 ± 0.065
4.121ProLeu: 4.121 ± 0.077
0.732ProMet: 0.732 ± 0.032
1.625ProAsn: 1.625 ± 0.056
0.737ProPro: 0.737 ± 0.035
2.273ProGln: 2.273 ± 0.056
1.475ProArg: 1.475 ± 0.044
1.814ProSer: 1.814 ± 0.052
2.768ProThr: 2.768 ± 0.071
2.957ProVal: 2.957 ± 0.069
0.359ProTrp: 0.359 ± 0.025
1.394ProTyr: 1.394 ± 0.051
0.0ProXaa: 0.0 ± 0.0
Gln
5.637GlnAla: 5.637 ± 0.116
0.142GlnCys: 0.142 ± 0.014
2.099GlnAsp: 2.099 ± 0.056
2.256GlnGlu: 2.256 ± 0.065
1.836GlnPhe: 1.836 ± 0.055
2.543GlnGly: 2.543 ± 0.068
1.472GlnHis: 1.472 ± 0.05
3.582GlnIle: 3.582 ± 0.065
2.913GlnLys: 2.913 ± 0.067
6.73GlnLeu: 6.73 ± 0.141
1.247GlnMet: 1.247 ± 0.043
2.096GlnAsn: 2.096 ± 0.059
2.409GlnPro: 2.409 ± 0.068
4.991GlnGln: 4.991 ± 0.18
3.17GlnArg: 3.17 ± 0.081
2.256GlnSer: 2.256 ± 0.056
3.384GlnThr: 3.384 ± 0.076
4.041GlnVal: 4.041 ± 0.075
0.533GlnTrp: 0.533 ± 0.032
1.628GlnTyr: 1.628 ± 0.055
0.0GlnXaa: 0.0 ± 0.0
Arg
3.251ArgAla: 3.251 ± 0.069
0.237ArgCys: 0.237 ± 0.022
2.389ArgAsp: 2.389 ± 0.058
2.383ArgGlu: 2.383 ± 0.062
2.001ArgPhe: 2.001 ± 0.061
2.634ArgGly: 2.634 ± 0.066
1.155ArgHis: 1.155 ± 0.048
2.689ArgIle: 2.689 ± 0.071
2.434ArgLys: 2.434 ± 0.065
4.891ArgLeu: 4.891 ± 0.099
1.049ArgMet: 1.049 ± 0.038
1.862ArgAsn: 1.862 ± 0.058
1.746ArgPro: 1.746 ± 0.051
3.04ArgGln: 3.04 ± 0.074
2.461ArgArg: 2.461 ± 0.078
2.069ArgSer: 2.069 ± 0.057
2.274ArgThr: 2.274 ± 0.062
2.855ArgVal: 2.855 ± 0.061
0.432ArgTrp: 0.432 ± 0.027
1.874ArgTyr: 1.874 ± 0.061
0.0ArgXaa: 0.0 ± 0.0
Ser
4.752SerAla: 4.752 ± 0.104
0.278SerCys: 0.278 ± 0.021
2.89SerAsp: 2.89 ± 0.054
2.664SerGlu: 2.664 ± 0.068
2.448SerPhe: 2.448 ± 0.062
4.572SerGly: 4.572 ± 0.098
1.191SerHis: 1.191 ± 0.04
3.382SerIle: 3.382 ± 0.079
2.578SerLys: 2.578 ± 0.068
5.483SerLeu: 5.483 ± 0.1
1.333SerMet: 1.333 ± 0.039
2.02SerAsn: 2.02 ± 0.056
1.803SerPro: 1.803 ± 0.054
2.56SerGln: 2.56 ± 0.069
2.332SerArg: 2.332 ± 0.064
3.173SerSer: 3.173 ± 0.135
3.177SerThr: 3.177 ± 0.079
3.822SerVal: 3.822 ± 0.077
0.565SerTrp: 0.565 ± 0.027
1.977SerTyr: 1.977 ± 0.054
0.0SerXaa: 0.0 ± 0.0
Thr
6.765ThrAla: 6.765 ± 0.127
0.27ThrCys: 0.27 ± 0.021
3.876ThrAsp: 3.876 ± 0.074
3.275ThrGlu: 3.275 ± 0.074
2.593ThrPhe: 2.593 ± 0.065
4.725ThrGly: 4.725 ± 0.093
1.199ThrHis: 1.199 ± 0.041
4.482ThrIle: 4.482 ± 0.084
3.666ThrLys: 3.666 ± 0.077
6.316ThrLeu: 6.316 ± 0.103
1.344ThrMet: 1.344 ± 0.048
2.614ThrAsn: 2.614 ± 0.066
3.183ThrPro: 3.183 ± 0.075
2.76ThrGln: 2.76 ± 0.068
2.211ThrArg: 2.211 ± 0.056
3.336ThrSer: 3.336 ± 0.074
4.811ThrThr: 4.811 ± 0.105
5.027ThrVal: 5.027 ± 0.089
0.618ThrTrp: 0.618 ± 0.034
2.076ThrTyr: 2.076 ± 0.068
0.0ThrXaa: 0.0 ± 0.0
Val
7.541ValAla: 7.541 ± 0.125
0.436ValCys: 0.436 ± 0.025
3.98ValAsp: 3.98 ± 0.092
3.31ValGlu: 3.31 ± 0.088
2.674ValPhe: 2.674 ± 0.067
5.001ValGly: 5.001 ± 0.095
1.356ValHis: 1.356 ± 0.055
5.311ValIle: 5.311 ± 0.094
3.983ValLys: 3.983 ± 0.097
7.007ValLeu: 7.007 ± 0.117
1.782ValMet: 1.782 ± 0.048
2.905ValAsn: 2.905 ± 0.071
2.972ValPro: 2.972 ± 0.066
2.721ValGln: 2.721 ± 0.069
2.763ValArg: 2.763 ± 0.068
4.107ValSer: 4.107 ± 0.074
5.469ValThr: 5.469 ± 0.085
5.418ValVal: 5.418 ± 0.091
0.616ValTrp: 0.616 ± 0.034
2.105ValTyr: 2.105 ± 0.062
0.0ValXaa: 0.0 ± 0.0
Trp
0.698TrpAla: 0.698 ± 0.037
0.074TrpCys: 0.074 ± 0.011
0.414TrpAsp: 0.414 ± 0.024
0.364TrpGlu: 0.364 ± 0.023
0.479TrpPhe: 0.479 ± 0.03
0.569TrpGly: 0.569 ± 0.032
0.293TrpHis: 0.293 ± 0.021
0.581TrpIle: 0.581 ± 0.031
0.291TrpLys: 0.291 ± 0.025
1.552TrpLeu: 1.552 ± 0.05
0.202TrpMet: 0.202 ± 0.017
0.374TrpAsn: 0.374 ± 0.025
0.335TrpPro: 0.335 ± 0.024
0.865TrpGln: 0.865 ± 0.043
0.607TrpArg: 0.607 ± 0.034
0.548TrpSer: 0.548 ± 0.03
0.509TrpThr: 0.509 ± 0.03
0.574TrpVal: 0.574 ± 0.032
0.189TrpTrp: 0.189 ± 0.018
0.341TrpTyr: 0.341 ± 0.026
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.845TyrAla: 2.845 ± 0.063
0.186TyrCys: 0.186 ± 0.016
1.927TyrAsp: 1.927 ± 0.059
1.578TyrGlu: 1.578 ± 0.051
1.755TyrPhe: 1.755 ± 0.049
2.428TyrGly: 2.428 ± 0.066
0.933TyrHis: 0.933 ± 0.038
1.909TyrIle: 1.909 ± 0.061
1.318TyrLys: 1.318 ± 0.041
4.005TyrLeu: 4.005 ± 0.08
0.698TyrMet: 0.698 ± 0.03
1.439TyrAsn: 1.439 ± 0.047
1.498TyrPro: 1.498 ± 0.048
2.463TyrGln: 2.463 ± 0.061
1.869TyrArg: 1.869 ± 0.053
1.755TyrSer: 1.755 ± 0.056
1.996TyrThr: 1.996 ± 0.066
2.164TyrVal: 2.164 ± 0.068
0.4TyrTrp: 0.4 ± 0.026
1.425TyrTyr: 1.425 ± 0.048
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2023 proteins (662235 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski