Amino acid dipepetide frequency for Bean necrotic mosaic virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
1.954AlaAla: 1.954 ± 1.98
1.758AlaCys: 1.758 ± 0.391
1.368AlaAsp: 1.368 ± 0.542
2.735AlaGlu: 2.735 ± 0.811
1.954AlaPhe: 1.954 ± 0.388
2.735AlaGly: 2.735 ± 0.901
0.782AlaHis: 0.782 ± 0.574
3.322AlaIle: 3.322 ± 1.305
3.908AlaLys: 3.908 ± 1.078
2.54AlaLeu: 2.54 ± 2.163
1.954AlaMet: 1.954 ± 0.355
1.758AlaAsn: 1.758 ± 0.435
1.368AlaPro: 1.368 ± 0.453
0.977AlaGln: 0.977 ± 0.359
0.391AlaArg: 0.391 ± 0.24
3.322AlaSer: 3.322 ± 0.754
2.149AlaThr: 2.149 ± 0.395
2.345AlaVal: 2.345 ± 0.394
0.0AlaTrp: 0.0 ± 0.0
0.391AlaTyr: 0.391 ± 0.492
0.0AlaXaa: 0.0 ± 0.0
Cys
0.391CysAla: 0.391 ± 0.178
0.586CysCys: 0.586 ± 0.658
0.782CysAsp: 0.782 ± 0.292
1.563CysGlu: 1.563 ± 0.407
1.563CysPhe: 1.563 ± 0.516
1.172CysGly: 1.172 ± 1.031
0.195CysHis: 0.195 ± 0.12
1.563CysIle: 1.563 ± 0.583
2.735CysLys: 2.735 ± 1.284
3.908CysLeu: 3.908 ± 1.448
0.586CysMet: 0.586 ± 0.21
1.563CysAsn: 1.563 ± 0.679
1.172CysPro: 1.172 ± 0.849
0.586CysGln: 0.586 ± 0.381
1.563CysArg: 1.563 ± 0.933
1.954CysSer: 1.954 ± 0.761
0.977CysThr: 0.977 ± 0.675
1.563CysVal: 1.563 ± 0.933
0.0CysTrp: 0.0 ± 0.0
1.172CysTyr: 1.172 ± 0.665
0.0CysXaa: 0.0 ± 0.0
Asp
1.758AspAla: 1.758 ± 1.334
0.0AspCys: 0.0 ± 0.0
3.126AspAsp: 3.126 ± 0.887
4.103AspGlu: 4.103 ± 0.5
2.735AspPhe: 2.735 ± 1.115
2.149AspGly: 2.149 ± 0.614
1.758AspHis: 1.758 ± 0.435
4.885AspIle: 4.885 ± 0.845
3.517AspLys: 3.517 ± 1.353
10.16AspLeu: 10.16 ± 1.873
1.563AspMet: 1.563 ± 0.732
2.149AspAsn: 2.149 ± 0.6
2.149AspPro: 2.149 ± 1.106
2.149AspGln: 2.149 ± 0.807
2.54AspArg: 2.54 ± 1.035
5.862AspSer: 5.862 ± 1.011
2.54AspThr: 2.54 ± 0.861
3.908AspVal: 3.908 ± 0.783
0.391AspTrp: 0.391 ± 0.24
2.149AspTyr: 2.149 ± 0.782
0.0AspXaa: 0.0 ± 0.0
Glu
1.954GluAla: 1.954 ± 0.89
0.977GluCys: 0.977 ± 0.366
4.885GluAsp: 4.885 ± 0.845
4.689GluGlu: 4.689 ± 1.214
3.517GluPhe: 3.517 ± 1.301
3.322GluGly: 3.322 ± 0.647
0.977GluHis: 0.977 ± 0.813
5.666GluIle: 5.666 ± 1.054
6.448GluLys: 6.448 ± 0.808
6.643GluLeu: 6.643 ± 1.029
2.931GluMet: 2.931 ± 1.168
3.908GluAsn: 3.908 ± 1.324
1.563GluPro: 1.563 ± 0.818
1.563GluGln: 1.563 ± 1.003
1.172GluArg: 1.172 ± 0.518
6.839GluSer: 6.839 ± 1.624
4.885GluThr: 4.885 ± 0.916
4.494GluVal: 4.494 ± 0.893
0.0GluTrp: 0.0 ± 0.0
2.54GluTyr: 2.54 ± 1.119
0.0GluXaa: 0.0 ± 0.0
Phe
1.368PheAla: 1.368 ± 0.657
1.368PheCys: 1.368 ± 0.95
3.322PheAsp: 3.322 ± 0.861
3.517PheGlu: 3.517 ± 0.704
1.954PhePhe: 1.954 ± 1.713
1.758PheGly: 1.758 ± 1.592
1.368PheHis: 1.368 ± 0.618
1.368PheIle: 1.368 ± 0.617
4.103PheLys: 4.103 ± 0.784
4.299PheLeu: 4.299 ± 0.822
1.563PheMet: 1.563 ± 0.626
5.471PheAsn: 5.471 ± 1.15
1.563PhePro: 1.563 ± 0.412
1.954PheGln: 1.954 ± 0.857
1.172PheArg: 1.172 ± 0.303
4.494PheSer: 4.494 ± 0.987
1.368PheThr: 1.368 ± 0.41
2.54PheVal: 2.54 ± 1.069
0.0PheTrp: 0.0 ± 0.0
1.563PheTyr: 1.563 ± 0.412
0.0PheXaa: 0.0 ± 0.0
Gly
1.172GlyAla: 1.172 ± 0.788
2.345GlyCys: 2.345 ± 1.002
3.322GlyAsp: 3.322 ± 1.039
2.345GlyGlu: 2.345 ± 0.51
2.931GlyPhe: 2.931 ± 0.81
1.368GlyGly: 1.368 ± 0.583
1.172GlyHis: 1.172 ± 0.44
3.126GlyIle: 3.126 ± 0.664
6.252GlyLys: 6.252 ± 1.458
3.322GlyLeu: 3.322 ± 0.732
1.172GlyMet: 1.172 ± 0.518
2.931GlyAsn: 2.931 ± 1.863
0.977GlyPro: 0.977 ± 0.393
0.586GlyGln: 0.586 ± 0.36
1.368GlyArg: 1.368 ± 0.658
5.275GlySer: 5.275 ± 1.509
2.931GlyThr: 2.931 ± 1.499
2.931GlyVal: 2.931 ± 1.567
0.586GlyTrp: 0.586 ± 0.677
2.735GlyTyr: 2.735 ± 0.705
0.0GlyXaa: 0.0 ± 0.0
His
0.977HisAla: 0.977 ± 0.497
0.391HisCys: 0.391 ± 0.492
0.391HisAsp: 0.391 ± 0.24
0.977HisGlu: 0.977 ± 0.497
0.977HisPhe: 0.977 ± 0.393
0.977HisGly: 0.977 ± 0.497
0.195HisHis: 0.195 ± 0.12
0.391HisIle: 0.391 ± 0.431
0.782HisLys: 0.782 ± 0.664
2.54HisLeu: 2.54 ± 1.024
0.0HisMet: 0.0 ± 0.0
1.368HisAsn: 1.368 ± 0.31
1.172HisPro: 1.172 ± 0.546
0.391HisGln: 0.391 ± 0.178
0.782HisArg: 0.782 ± 0.479
0.977HisSer: 0.977 ± 0.599
1.758HisThr: 1.758 ± 0.629
1.368HisVal: 1.368 ± 0.746
0.195HisTrp: 0.195 ± 0.12
0.782HisTyr: 0.782 ± 0.356
0.0HisXaa: 0.0 ± 0.0
Ile
3.712IleAla: 3.712 ± 0.472
2.345IleCys: 2.345 ± 0.732
4.299IleAsp: 4.299 ± 0.842
3.908IleGlu: 3.908 ± 1.33
2.735IlePhe: 2.735 ± 0.472
2.931IleGly: 2.931 ± 1.004
1.172IleHis: 1.172 ± 0.962
4.885IleIle: 4.885 ± 0.779
7.034IleLys: 7.034 ± 1.002
4.885IleLeu: 4.885 ± 1.148
1.758IleMet: 1.758 ± 0.626
5.666IleAsn: 5.666 ± 1.028
2.931IlePro: 2.931 ± 0.807
1.172IleGln: 1.172 ± 0.303
1.758IleArg: 1.758 ± 0.867
7.425IleSer: 7.425 ± 0.632
4.494IleThr: 4.494 ± 1.184
4.299IleVal: 4.299 ± 1.443
0.391IleTrp: 0.391 ± 0.492
3.322IleTyr: 3.322 ± 0.97
0.0IleXaa: 0.0 ± 0.0
Lys
4.299LysAla: 4.299 ± 2.438
2.54LysCys: 2.54 ± 1.228
4.689LysAsp: 4.689 ± 0.58
6.839LysGlu: 6.839 ± 1.654
3.712LysPhe: 3.712 ± 0.782
5.471LysGly: 5.471 ± 1.202
1.758LysHis: 1.758 ± 0.937
8.011LysIle: 8.011 ± 0.796
7.816LysLys: 7.816 ± 1.153
8.402LysLeu: 8.402 ± 1.526
2.931LysMet: 2.931 ± 0.49
4.885LysAsn: 4.885 ± 1.637
2.54LysPro: 2.54 ± 0.762
2.54LysGln: 2.54 ± 1.613
2.931LysArg: 2.931 ± 1.084
7.816LysSer: 7.816 ± 0.76
6.057LysThr: 6.057 ± 1.6
5.275LysVal: 5.275 ± 1.427
0.586LysTrp: 0.586 ± 0.21
2.345LysTyr: 2.345 ± 0.715
0.0LysXaa: 0.0 ± 0.0
Leu
3.712LeuAla: 3.712 ± 1.04
2.54LeuCys: 2.54 ± 0.739
5.862LeuAsp: 5.862 ± 1.123
5.862LeuGlu: 5.862 ± 1.155
2.931LeuPhe: 2.931 ± 0.824
7.229LeuGly: 7.229 ± 1.666
1.368LeuHis: 1.368 ± 0.617
5.08LeuIle: 5.08 ± 1.09
10.16LeuLys: 10.16 ± 1.665
7.62LeuLeu: 7.62 ± 1.382
4.299LeuMet: 4.299 ± 1.859
7.034LeuAsn: 7.034 ± 1.743
3.126LeuPro: 3.126 ± 1.09
1.758LeuGln: 1.758 ± 0.954
3.322LeuArg: 3.322 ± 0.605
13.482LeuSer: 13.482 ± 1.521
4.885LeuThr: 4.885 ± 0.956
4.103LeuVal: 4.103 ± 0.974
0.586LeuTrp: 0.586 ± 0.658
3.126LeuTyr: 3.126 ± 1.167
0.0LeuXaa: 0.0 ± 0.0
Met
0.977MetAla: 0.977 ± 0.393
0.195MetCys: 0.195 ± 0.12
1.368MetAsp: 1.368 ± 0.494
1.563MetGlu: 1.563 ± 0.705
1.172MetPhe: 1.172 ± 0.42
1.368MetGly: 1.368 ± 0.444
0.0MetHis: 0.0 ± 0.0
2.149MetIle: 2.149 ± 1.152
3.517MetLys: 3.517 ± 1.277
3.322MetLeu: 3.322 ± 0.758
1.368MetMet: 1.368 ± 0.668
2.735MetAsn: 2.735 ± 0.98
0.977MetPro: 0.977 ± 0.359
1.758MetGln: 1.758 ± 0.413
1.172MetArg: 1.172 ± 0.518
2.54MetSer: 2.54 ± 0.306
2.149MetThr: 2.149 ± 0.421
1.172MetVal: 1.172 ± 0.719
0.0MetTrp: 0.0 ± 0.0
1.368MetTyr: 1.368 ± 0.36
0.0MetXaa: 0.0 ± 0.0
Asn
2.149AsnAla: 2.149 ± 1.205
0.977AsnCys: 0.977 ± 0.914
4.103AsnAsp: 4.103 ± 1.005
6.252AsnGlu: 6.252 ± 1.003
3.126AsnPhe: 3.126 ± 0.721
2.54AsnGly: 2.54 ± 0.84
0.782AsnHis: 0.782 ± 0.371
4.299AsnIle: 4.299 ± 1.323
3.517AsnLys: 3.517 ± 0.793
7.425AsnLeu: 7.425 ± 0.411
1.954AsnMet: 1.954 ± 0.85
2.54AsnAsn: 2.54 ± 0.845
2.149AsnPro: 2.149 ± 0.399
2.149AsnGln: 2.149 ± 0.509
1.758AsnArg: 1.758 ± 0.452
3.712AsnSer: 3.712 ± 1.044
3.126AsnThr: 3.126 ± 1.065
3.517AsnVal: 3.517 ± 0.963
1.563AsnTrp: 1.563 ± 1.477
2.345AsnTyr: 2.345 ± 0.97
0.0AsnXaa: 0.0 ± 0.0
Pro
0.586ProAla: 0.586 ± 0.421
0.0ProCys: 0.0 ± 0.0
2.345ProAsp: 2.345 ± 0.316
2.345ProGlu: 2.345 ± 0.946
1.172ProPhe: 1.172 ± 0.534
1.758ProGly: 1.758 ± 1.066
0.0ProHis: 0.0 ± 0.0
3.126ProIle: 3.126 ± 1.544
2.345ProLys: 2.345 ± 0.786
2.735ProLeu: 2.735 ± 0.879
0.391ProMet: 0.391 ± 0.24
2.345ProAsn: 2.345 ± 0.644
0.977ProPro: 0.977 ± 0.941
1.368ProGln: 1.368 ± 0.494
0.586ProArg: 0.586 ± 0.421
2.931ProSer: 2.931 ± 1.12
1.563ProThr: 1.563 ± 0.822
2.345ProVal: 2.345 ± 0.607
0.391ProTrp: 0.391 ± 0.24
0.977ProTyr: 0.977 ± 0.393
0.0ProXaa: 0.0 ± 0.0
Gln
1.758GlnAla: 1.758 ± 0.488
0.391GlnCys: 0.391 ± 0.431
1.563GlnAsp: 1.563 ± 0.713
2.345GlnGlu: 2.345 ± 0.709
0.586GlnPhe: 0.586 ± 0.425
1.172GlnGly: 1.172 ± 0.497
0.0GlnHis: 0.0 ± 0.0
3.126GlnIle: 3.126 ± 1.317
1.954GlnLys: 1.954 ± 0.811
1.758GlnLeu: 1.758 ± 0.481
1.172GlnMet: 1.172 ± 0.303
1.172GlnAsn: 1.172 ± 0.503
0.782GlnPro: 0.782 ± 0.292
0.586GlnGln: 0.586 ± 0.419
0.977GlnArg: 0.977 ± 0.599
2.735GlnSer: 2.735 ± 1.245
3.712GlnThr: 3.712 ± 0.595
0.782GlnVal: 0.782 ± 0.266
0.195GlnTrp: 0.195 ± 0.12
0.977GlnTyr: 0.977 ± 0.37
0.0GlnXaa: 0.0 ± 0.0
Arg
0.391ArgAla: 0.391 ± 0.405
0.586ArgCys: 0.586 ± 0.318
1.954ArgAsp: 1.954 ± 1.198
2.345ArgGlu: 2.345 ± 0.875
2.149ArgPhe: 2.149 ± 0.568
1.758ArgGly: 1.758 ± 0.352
0.586ArgHis: 0.586 ± 0.36
1.563ArgIle: 1.563 ± 0.583
2.931ArgLys: 2.931 ± 0.448
2.54ArgLeu: 2.54 ± 0.828
0.586ArgMet: 0.586 ± 0.21
2.931ArgAsn: 2.931 ± 0.746
0.391ArgPro: 0.391 ± 0.24
0.586ArgGln: 0.586 ± 0.21
0.977ArgArg: 0.977 ± 0.497
1.563ArgSer: 1.563 ± 0.478
2.54ArgThr: 2.54 ± 0.815
2.735ArgVal: 2.735 ± 0.647
0.391ArgTrp: 0.391 ± 0.24
1.758ArgTyr: 1.758 ± 0.656
0.0ArgXaa: 0.0 ± 0.0
Ser
3.126SerAla: 3.126 ± 0.562
2.149SerCys: 2.149 ± 0.785
6.448SerAsp: 6.448 ± 1.599
7.425SerGlu: 7.425 ± 1.362
4.885SerPhe: 4.885 ± 0.723
4.885SerGly: 4.885 ± 0.941
0.977SerHis: 0.977 ± 0.259
5.08SerIle: 5.08 ± 1.286
8.792SerLys: 8.792 ± 1.527
10.942SerLeu: 10.942 ± 0.824
2.735SerMet: 2.735 ± 0.896
4.103SerAsn: 4.103 ± 0.417
2.54SerPro: 2.54 ± 1.362
3.322SerGln: 3.322 ± 0.609
4.103SerArg: 4.103 ± 0.926
10.746SerSer: 10.746 ± 1.601
4.689SerThr: 4.689 ± 0.639
4.299SerVal: 4.299 ± 1.591
0.586SerTrp: 0.586 ± 0.421
4.494SerTyr: 4.494 ± 1.462
0.0SerXaa: 0.0 ± 0.0
Thr
2.931ThrAla: 2.931 ± 0.777
2.345ThrCys: 2.345 ± 1.788
2.345ThrAsp: 2.345 ± 1.183
3.712ThrGlu: 3.712 ± 1.186
2.735ThrPhe: 2.735 ± 1.734
3.322ThrGly: 3.322 ± 0.6
2.54ThrHis: 2.54 ± 0.478
4.689ThrIle: 4.689 ± 1.101
5.275ThrLys: 5.275 ± 0.794
5.666ThrLeu: 5.666 ± 0.707
1.368ThrMet: 1.368 ± 0.459
3.126ThrAsn: 3.126 ± 1.371
1.368ThrPro: 1.368 ± 0.458
1.368ThrGln: 1.368 ± 0.839
1.954ThrArg: 1.954 ± 0.497
4.103ThrSer: 4.103 ± 0.622
3.126ThrThr: 3.126 ± 1.288
2.931ThrVal: 2.931 ± 1.089
0.391ThrTrp: 0.391 ± 0.178
2.54ThrTyr: 2.54 ± 0.679
0.0ThrXaa: 0.0 ± 0.0
Val
2.149ValAla: 2.149 ± 0.821
1.954ValCys: 1.954 ± 0.458
4.299ValAsp: 4.299 ± 0.337
3.517ValGlu: 3.517 ± 0.682
2.735ValPhe: 2.735 ± 1.196
1.758ValGly: 1.758 ± 0.48
0.977ValHis: 0.977 ± 0.393
4.299ValIle: 4.299 ± 0.989
5.862ValLys: 5.862 ± 0.705
5.08ValLeu: 5.08 ± 1.046
1.563ValMet: 1.563 ± 0.533
3.126ValAsn: 3.126 ± 0.649
1.172ValPro: 1.172 ± 0.636
1.368ValGln: 1.368 ± 0.747
1.758ValArg: 1.758 ± 0.748
5.471ValSer: 5.471 ± 0.956
2.54ValThr: 2.54 ± 0.552
1.563ValVal: 1.563 ± 0.443
0.195ValTrp: 0.195 ± 0.469
3.126ValTyr: 3.126 ± 0.415
0.0ValXaa: 0.0 ± 0.0
Trp
0.0TrpAla: 0.0 ± 0.0
0.391TrpCys: 0.391 ± 0.431
0.586TrpAsp: 0.586 ± 0.705
0.586TrpGlu: 0.586 ± 0.21
0.195TrpPhe: 0.195 ± 0.219
0.195TrpGly: 0.195 ± 0.219
0.195TrpHis: 0.195 ± 0.219
0.782TrpIle: 0.782 ± 0.705
0.586TrpLys: 0.586 ± 0.421
0.782TrpLeu: 0.782 ± 0.479
0.195TrpMet: 0.195 ± 0.12
0.0TrpAsn: 0.0 ± 0.0
0.0TrpPro: 0.0 ± 0.0
0.195TrpGln: 0.195 ± 0.219
0.0TrpArg: 0.0 ± 0.0
0.782TrpSer: 0.782 ± 0.535
0.782TrpThr: 0.782 ± 0.479
0.195TrpVal: 0.195 ± 0.365
0.0TrpTrp: 0.0 ± 0.0
0.195TrpTyr: 0.195 ± 0.219
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.345TyrAla: 2.345 ± 0.603
1.758TyrCys: 1.758 ± 0.629
2.54TyrAsp: 2.54 ± 0.909
2.345TyrGlu: 2.345 ± 1.202
2.345TyrPhe: 2.345 ± 0.422
0.977TyrGly: 0.977 ± 0.832
0.586TyrHis: 0.586 ± 0.381
3.712TyrIle: 3.712 ± 0.708
3.908TyrLys: 3.908 ± 0.753
3.517TyrLeu: 3.517 ± 0.963
0.586TyrMet: 0.586 ± 0.425
1.172TyrAsn: 1.172 ± 0.503
1.368TyrPro: 1.368 ± 0.388
1.368TyrGln: 1.368 ± 0.976
0.977TyrArg: 0.977 ± 0.37
4.299TyrSer: 4.299 ± 0.415
1.758TyrThr: 1.758 ± 0.413
2.149TyrVal: 2.149 ± 1.257
0.195TyrTrp: 0.195 ± 0.365
1.758TyrTyr: 1.758 ± 0.48
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5 proteins (5119 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski