Amino acid dipepetide frequency for Streptococcus satellite phage Javan401

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
0.0AlaAla: 0.0 ± 0.0
0.361AlaCys: 0.361 ± 0.281
3.25AlaAsp: 3.25 ± 0.881
5.778AlaGlu: 5.778 ± 1.835
1.806AlaPhe: 1.806 ± 0.716
2.167AlaGly: 2.167 ± 0.691
0.0AlaHis: 0.0 ± 0.0
5.778AlaIle: 5.778 ± 1.373
3.25AlaLys: 3.25 ± 1.242
5.778AlaLeu: 5.778 ± 1.261
2.167AlaMet: 2.167 ± 0.62
3.973AlaAsn: 3.973 ± 0.812
2.889AlaPro: 2.889 ± 1.226
2.528AlaGln: 2.528 ± 0.809
2.167AlaArg: 2.167 ± 0.651
0.722AlaSer: 0.722 ± 0.325
4.695AlaThr: 4.695 ± 1.624
2.167AlaVal: 2.167 ± 0.895
0.0AlaTrp: 0.0 ± 0.0
2.889AlaTyr: 2.889 ± 1.006
0.0AlaXaa: 0.0 ± 0.0
Cys
0.722CysAla: 0.722 ± 0.634
0.0CysCys: 0.0 ± 0.0
1.083CysAsp: 1.083 ± 0.497
0.361CysGlu: 0.361 ± 0.377
0.0CysPhe: 0.0 ± 0.0
0.361CysGly: 0.361 ± 0.361
0.361CysHis: 0.361 ± 0.281
1.445CysIle: 1.445 ± 0.659
0.361CysLys: 0.361 ± 0.394
0.361CysLeu: 0.361 ± 0.317
0.361CysMet: 0.361 ± 0.377
0.722CysAsn: 0.722 ± 0.563
0.361CysPro: 0.361 ± 0.285
0.0CysGln: 0.0 ± 0.0
0.361CysArg: 0.361 ± 0.285
0.0CysSer: 0.0 ± 0.0
0.0CysThr: 0.0 ± 0.0
0.0CysVal: 0.0 ± 0.0
0.0CysTrp: 0.0 ± 0.0
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
0.361AspAla: 0.361 ± 0.375
1.445AspCys: 1.445 ± 1.07
4.695AspAsp: 4.695 ± 1.003
3.25AspGlu: 3.25 ± 1.336
4.334AspPhe: 4.334 ± 1.2
2.167AspGly: 2.167 ± 0.781
1.445AspHis: 1.445 ± 0.61
8.306AspIle: 8.306 ± 1.215
5.778AspLys: 5.778 ± 1.738
5.417AspLeu: 5.417 ± 1.362
3.25AspMet: 3.25 ± 0.928
2.889AspAsn: 2.889 ± 1.178
0.722AspPro: 0.722 ± 0.563
2.889AspGln: 2.889 ± 0.882
2.889AspArg: 2.889 ± 0.776
0.722AspSer: 0.722 ± 0.563
5.778AspThr: 5.778 ± 2.595
0.361AspVal: 0.361 ± 0.285
0.0AspTrp: 0.0 ± 0.0
7.223AspTyr: 7.223 ± 1.625
0.0AspXaa: 0.0 ± 0.0
Glu
7.945GluAla: 7.945 ± 1.291
0.722GluCys: 0.722 ± 0.488
2.889GluAsp: 2.889 ± 1.083
5.778GluGlu: 5.778 ± 1.718
1.806GluPhe: 1.806 ± 0.867
1.445GluGly: 1.445 ± 0.659
1.806GluHis: 1.806 ± 0.813
4.695GluIle: 4.695 ± 1.105
7.584GluLys: 7.584 ± 1.908
8.667GluLeu: 8.667 ± 2.566
2.167GluMet: 2.167 ± 0.707
5.056GluAsn: 5.056 ± 0.794
3.25GluPro: 3.25 ± 1.18
3.25GluGln: 3.25 ± 1.403
3.611GluArg: 3.611 ± 1.042
2.167GluSer: 2.167 ± 0.73
3.25GluThr: 3.25 ± 1.145
4.695GluVal: 4.695 ± 1.113
0.361GluTrp: 0.361 ± 0.281
3.611GluTyr: 3.611 ± 0.845
0.0GluXaa: 0.0 ± 0.0
Phe
0.722PheAla: 0.722 ± 0.472
0.0PheCys: 0.0 ± 0.0
4.695PheAsp: 4.695 ± 1.334
3.611PheGlu: 3.611 ± 1.09
0.722PhePhe: 0.722 ± 0.515
3.611PheGly: 3.611 ± 0.933
0.722PheHis: 0.722 ± 0.427
5.056PheIle: 5.056 ± 1.422
5.056PheLys: 5.056 ± 1.392
2.889PheLeu: 2.889 ± 1.094
0.361PheMet: 0.361 ± 0.355
3.611PheAsn: 3.611 ± 1.148
0.361PhePro: 0.361 ± 0.327
0.722PheGln: 0.722 ± 0.563
1.806PheArg: 1.806 ± 0.674
2.528PheSer: 2.528 ± 0.875
2.889PheThr: 2.889 ± 0.982
1.083PheVal: 1.083 ± 0.495
0.0PheTrp: 0.0 ± 0.0
2.167PheTyr: 2.167 ± 1.225
0.0PheXaa: 0.0 ± 0.0
Gly
2.528GlyAla: 2.528 ± 1.117
0.722GlyCys: 0.722 ± 0.569
3.25GlyAsp: 3.25 ± 0.979
1.083GlyGlu: 1.083 ± 0.663
1.445GlyPhe: 1.445 ± 0.847
2.889GlyGly: 2.889 ± 0.932
1.445GlyHis: 1.445 ± 0.905
3.611GlyIle: 3.611 ± 1.083
5.778GlyLys: 5.778 ± 1.954
2.528GlyLeu: 2.528 ± 1.444
1.445GlyMet: 1.445 ± 0.686
4.334GlyAsn: 4.334 ± 1.484
0.0GlyPro: 0.0 ± 0.0
1.806GlyGln: 1.806 ± 0.753
2.167GlyArg: 2.167 ± 0.847
2.528GlySer: 2.528 ± 0.932
2.889GlyThr: 2.889 ± 0.831
2.528GlyVal: 2.528 ± 0.957
1.445GlyTrp: 1.445 ± 0.912
3.25GlyTyr: 3.25 ± 0.829
0.0GlyXaa: 0.0 ± 0.0
His
3.611HisAla: 3.611 ± 1.169
0.361HisCys: 0.361 ± 0.281
1.445HisAsp: 1.445 ± 0.899
1.445HisGlu: 1.445 ± 0.707
2.167HisPhe: 2.167 ± 0.679
0.361HisGly: 0.361 ± 0.332
0.361HisHis: 0.361 ± 0.317
1.083HisIle: 1.083 ± 0.631
1.083HisLys: 1.083 ± 0.599
2.528HisLeu: 2.528 ± 0.771
0.0HisMet: 0.0 ± 0.0
0.722HisAsn: 0.722 ± 0.569
0.0HisPro: 0.0 ± 0.0
0.0HisGln: 0.0 ± 0.0
0.0HisArg: 0.0 ± 0.0
1.083HisSer: 1.083 ± 0.495
1.445HisThr: 1.445 ± 0.672
0.361HisVal: 0.361 ± 0.281
0.361HisTrp: 0.361 ± 0.409
0.0HisTyr: 0.0 ± 0.0
0.0HisXaa: 0.0 ± 0.0
Ile
5.056IleAla: 5.056 ± 1.032
0.722IleCys: 0.722 ± 0.723
7.223IleAsp: 7.223 ± 1.711
4.334IleGlu: 4.334 ± 1.561
2.889IlePhe: 2.889 ± 0.921
3.611IleGly: 3.611 ± 1.244
1.083IleHis: 1.083 ± 0.5
5.778IleIle: 5.778 ± 1.593
10.112IleLys: 10.112 ± 1.833
6.862IleLeu: 6.862 ± 2.064
1.806IleMet: 1.806 ± 0.795
6.139IleAsn: 6.139 ± 1.499
3.611IlePro: 3.611 ± 1.35
1.445IleGln: 1.445 ± 0.357
3.611IleArg: 3.611 ± 0.767
5.778IleSer: 5.778 ± 1.243
6.862IleThr: 6.862 ± 1.474
2.167IleVal: 2.167 ± 0.876
0.361IleTrp: 0.361 ± 0.281
2.528IleTyr: 2.528 ± 0.969
0.0IleXaa: 0.0 ± 0.0
Lys
9.751LysAla: 9.751 ± 1.945
0.0LysCys: 0.0 ± 0.0
3.25LysAsp: 3.25 ± 0.871
11.557LysGlu: 11.557 ± 2.459
4.334LysPhe: 4.334 ± 1.424
2.889LysGly: 2.889 ± 1.127
2.167LysHis: 2.167 ± 0.667
6.501LysIle: 6.501 ± 1.809
9.751LysLys: 9.751 ± 2.477
9.39LysLeu: 9.39 ± 1.986
5.056LysMet: 5.056 ± 1.863
6.501LysAsn: 6.501 ± 1.637
4.334LysPro: 4.334 ± 1.205
3.973LysGln: 3.973 ± 1.106
5.056LysArg: 5.056 ± 1.075
2.167LysSer: 2.167 ± 1.312
5.056LysThr: 5.056 ± 0.979
2.889LysVal: 2.889 ± 0.817
0.361LysTrp: 0.361 ± 0.281
3.611LysTyr: 3.611 ± 0.754
0.0LysXaa: 0.0 ± 0.0
Leu
5.417LeuAla: 5.417 ± 1.237
0.722LeuCys: 0.722 ± 0.563
7.945LeuAsp: 7.945 ± 1.893
7.223LeuGlu: 7.223 ± 1.874
2.889LeuPhe: 2.889 ± 1.077
4.695LeuGly: 4.695 ± 1.255
0.361LeuHis: 0.361 ± 0.281
7.945LeuIle: 7.945 ± 1.435
8.306LeuLys: 8.306 ± 1.596
9.751LeuLeu: 9.751 ± 0.957
1.083LeuMet: 1.083 ± 0.65
4.695LeuAsn: 4.695 ± 1.263
3.973LeuPro: 3.973 ± 1.244
4.334LeuGln: 4.334 ± 1.155
3.611LeuArg: 3.611 ± 0.895
6.139LeuSer: 6.139 ± 1.155
6.862LeuThr: 6.862 ± 1.503
3.25LeuVal: 3.25 ± 1.088
0.722LeuTrp: 0.722 ± 0.325
5.778LeuTyr: 5.778 ± 0.871
0.0LeuXaa: 0.0 ± 0.0
Met
2.528MetAla: 2.528 ± 0.9
0.0MetCys: 0.0 ± 0.0
0.361MetAsp: 0.361 ± 0.285
1.445MetGlu: 1.445 ± 0.645
0.361MetPhe: 0.361 ± 0.409
0.722MetGly: 0.722 ± 0.469
0.0MetHis: 0.0 ± 0.0
2.167MetIle: 2.167 ± 0.79
3.973MetLys: 3.973 ± 1.12
1.806MetLeu: 1.806 ± 0.859
0.0MetMet: 0.0 ± 0.0
2.167MetAsn: 2.167 ± 0.868
0.361MetPro: 0.361 ± 0.361
1.083MetGln: 1.083 ± 0.789
2.528MetArg: 2.528 ± 0.819
3.25MetSer: 3.25 ± 1.581
2.167MetThr: 2.167 ± 0.877
1.806MetVal: 1.806 ± 0.854
0.0MetTrp: 0.0 ± 0.0
0.722MetTyr: 0.722 ± 0.549
0.0MetXaa: 0.0 ± 0.0
Asn
2.889AsnAla: 2.889 ± 1.139
1.083AsnCys: 1.083 ± 0.536
4.695AsnAsp: 4.695 ± 1.453
6.139AsnGlu: 6.139 ± 1.557
2.889AsnPhe: 2.889 ± 1.043
5.056AsnGly: 5.056 ± 1.803
1.083AsnHis: 1.083 ± 0.497
4.695AsnIle: 4.695 ± 1.572
5.056AsnLys: 5.056 ± 1.513
5.778AsnLeu: 5.778 ± 1.212
1.083AsnMet: 1.083 ± 0.673
2.889AsnAsn: 2.889 ± 1.708
2.167AsnPro: 2.167 ± 0.74
1.445AsnGln: 1.445 ± 0.563
2.167AsnArg: 2.167 ± 0.751
3.973AsnSer: 3.973 ± 1.07
3.25AsnThr: 3.25 ± 0.879
1.445AsnVal: 1.445 ± 0.773
0.0AsnTrp: 0.0 ± 0.0
2.889AsnTyr: 2.889 ± 1.238
0.0AsnXaa: 0.0 ± 0.0
Pro
0.722ProAla: 0.722 ± 0.464
0.0ProCys: 0.0 ± 0.0
1.806ProAsp: 1.806 ± 0.657
3.25ProGlu: 3.25 ± 1.294
2.167ProPhe: 2.167 ± 0.932
0.0ProGly: 0.0 ± 0.0
0.0ProHis: 0.0 ± 0.0
1.083ProIle: 1.083 ± 0.604
4.334ProLys: 4.334 ± 1.098
2.889ProLeu: 2.889 ± 1.078
1.445ProMet: 1.445 ± 0.747
1.806ProAsn: 1.806 ± 0.873
2.167ProPro: 2.167 ± 0.9
1.445ProGln: 1.445 ± 0.708
2.889ProArg: 2.889 ± 1.077
0.361ProSer: 0.361 ± 0.394
2.528ProThr: 2.528 ± 0.863
1.445ProVal: 1.445 ± 0.599
0.0ProTrp: 0.0 ± 0.0
2.167ProTyr: 2.167 ± 1.082
0.0ProXaa: 0.0 ± 0.0
Gln
3.611GlnAla: 3.611 ± 1.035
0.0GlnCys: 0.0 ± 0.0
0.722GlnAsp: 0.722 ± 0.39
2.889GlnGlu: 2.889 ± 1.057
1.083GlnPhe: 1.083 ± 0.566
3.611GlnGly: 3.611 ± 1.275
1.445GlnHis: 1.445 ± 0.481
3.611GlnIle: 3.611 ± 1.062
1.445GlnLys: 1.445 ± 0.982
5.417GlnLeu: 5.417 ± 1.3
0.722GlnMet: 0.722 ± 0.57
0.722GlnAsn: 0.722 ± 0.464
0.361GlnPro: 0.361 ± 0.327
1.445GlnGln: 1.445 ± 0.892
1.083GlnArg: 1.083 ± 0.551
2.167GlnSer: 2.167 ± 0.8
2.528GlnThr: 2.528 ± 0.987
1.083GlnVal: 1.083 ± 0.612
0.361GlnTrp: 0.361 ± 0.281
2.528GlnTyr: 2.528 ± 0.78
0.0GlnXaa: 0.0 ± 0.0
Arg
1.083ArgAla: 1.083 ± 0.482
0.0ArgCys: 0.0 ± 0.0
3.973ArgAsp: 3.973 ± 0.796
1.806ArgGlu: 1.806 ± 0.654
1.083ArgPhe: 1.083 ± 0.631
2.889ArgGly: 2.889 ± 1.137
0.361ArgHis: 0.361 ± 0.285
2.528ArgIle: 2.528 ± 0.593
6.139ArgLys: 6.139 ± 1.268
6.501ArgLeu: 6.501 ± 1.205
1.445ArgMet: 1.445 ± 0.668
1.445ArgAsn: 1.445 ± 0.649
1.083ArgPro: 1.083 ± 0.599
1.806ArgGln: 1.806 ± 0.981
1.806ArgArg: 1.806 ± 0.683
1.083ArgSer: 1.083 ± 0.808
4.334ArgThr: 4.334 ± 1.218
3.973ArgVal: 3.973 ± 0.918
0.361ArgTrp: 0.361 ± 0.413
1.083ArgTyr: 1.083 ± 0.659
0.0ArgXaa: 0.0 ± 0.0
Ser
1.445SerAla: 1.445 ± 0.642
0.0SerCys: 0.0 ± 0.0
4.695SerAsp: 4.695 ± 1.521
2.167SerGlu: 2.167 ± 0.753
2.528SerPhe: 2.528 ± 0.875
2.889SerGly: 2.889 ± 0.989
1.806SerHis: 1.806 ± 0.694
3.973SerIle: 3.973 ± 1.629
4.695SerLys: 4.695 ± 0.981
4.695SerLeu: 4.695 ± 1.173
0.361SerMet: 0.361 ± 0.409
3.25SerAsn: 3.25 ± 1.024
0.722SerPro: 0.722 ± 0.372
1.445SerGln: 1.445 ± 0.71
2.167SerArg: 2.167 ± 0.736
2.167SerSer: 2.167 ± 0.943
2.167SerThr: 2.167 ± 1.276
1.806SerVal: 1.806 ± 0.751
0.0SerTrp: 0.0 ± 0.0
3.973SerTyr: 3.973 ± 1.812
0.0SerXaa: 0.0 ± 0.0
Thr
2.528ThrAla: 2.528 ± 0.682
0.361ThrCys: 0.361 ± 0.281
3.973ThrAsp: 3.973 ± 1.3
3.973ThrGlu: 3.973 ± 0.989
5.778ThrPhe: 5.778 ± 1.008
4.695ThrGly: 4.695 ± 1.03
0.722ThrHis: 0.722 ± 0.471
5.417ThrIle: 5.417 ± 1.699
5.778ThrLys: 5.778 ± 0.996
7.945ThrLeu: 7.945 ± 1.509
2.167ThrMet: 2.167 ± 0.839
2.167ThrAsn: 2.167 ± 0.625
2.889ThrPro: 2.889 ± 0.748
2.167ThrGln: 2.167 ± 0.985
1.806ThrArg: 1.806 ± 0.563
2.528ThrSer: 2.528 ± 0.617
3.973ThrThr: 3.973 ± 0.95
5.778ThrVal: 5.778 ± 1.413
1.083ThrTrp: 1.083 ± 0.57
2.889ThrTyr: 2.889 ± 1.14
0.0ThrXaa: 0.0 ± 0.0
Val
1.445ValAla: 1.445 ± 0.549
0.0ValCys: 0.0 ± 0.0
2.167ValAsp: 2.167 ± 1.082
2.167ValGlu: 2.167 ± 0.613
1.806ValPhe: 1.806 ± 0.795
1.806ValGly: 1.806 ± 0.584
0.722ValHis: 0.722 ± 0.569
3.25ValIle: 3.25 ± 0.789
5.417ValLys: 5.417 ± 1.171
2.167ValLeu: 2.167 ± 0.903
0.722ValMet: 0.722 ± 0.543
2.889ValAsn: 2.889 ± 1.047
1.806ValPro: 1.806 ± 0.743
1.083ValGln: 1.083 ± 0.609
1.445ValArg: 1.445 ± 0.67
2.889ValSer: 2.889 ± 1.068
5.056ValThr: 5.056 ± 1.19
1.806ValVal: 1.806 ± 0.689
0.0ValTrp: 0.0 ± 0.0
2.167ValTyr: 2.167 ± 0.731
0.0ValXaa: 0.0 ± 0.0
Trp
0.0TrpAla: 0.0 ± 0.0
0.0TrpCys: 0.0 ± 0.0
0.0TrpAsp: 0.0 ± 0.0
1.083TrpGlu: 1.083 ± 0.554
0.722TrpPhe: 0.722 ± 0.563
0.361TrpGly: 0.361 ± 0.281
0.361TrpHis: 0.361 ± 0.281
0.361TrpIle: 0.361 ± 0.281
0.0TrpLys: 0.0 ± 0.0
0.722TrpLeu: 0.722 ± 0.511
0.0TrpMet: 0.0 ± 0.0
0.0TrpAsn: 0.0 ± 0.0
0.0TrpPro: 0.0 ± 0.0
0.722TrpGln: 0.722 ± 0.48
0.361TrpArg: 0.361 ± 0.281
0.722TrpSer: 0.722 ± 0.471
0.0TrpThr: 0.0 ± 0.0
0.0TrpVal: 0.0 ± 0.0
0.0TrpTrp: 0.0 ± 0.0
0.361TrpTyr: 0.361 ± 0.281
0.0TrpXaa: 0.0 ± 0.0
Tyr
0.0TyrAla: 0.0 ± 0.0
0.361TyrCys: 0.361 ± 0.327
1.806TyrAsp: 1.806 ± 0.843
5.417TyrGlu: 5.417 ± 1.72
1.806TyrPhe: 1.806 ± 0.691
1.445TyrGly: 1.445 ± 0.574
2.167TyrHis: 2.167 ± 0.76
4.695TyrIle: 4.695 ± 1.281
4.695TyrLys: 4.695 ± 1.293
3.973TyrLeu: 3.973 ± 1.428
1.445TyrMet: 1.445 ± 0.527
4.695TyrAsn: 4.695 ± 1.123
1.445TyrPro: 1.445 ± 0.738
3.25TyrGln: 3.25 ± 1.366
3.25TyrArg: 3.25 ± 1.099
3.973TyrSer: 3.973 ± 0.874
2.889TyrThr: 2.889 ± 0.946
2.167TyrVal: 2.167 ± 0.68
0.361TyrTrp: 0.361 ± 0.409
2.889TyrTyr: 2.889 ± 0.908
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 19 proteins (2770 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski