Amino acid dipepetide frequency for uncultured phage_MedDCM-OCT-S31-C1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
11.735AlaAla: 11.735 ± 1.324
0.66AlaCys: 0.66 ± 0.227
5.941AlaAsp: 5.941 ± 0.57
8.068AlaGlu: 8.068 ± 0.872
2.787AlaPhe: 2.787 ± 0.432
7.701AlaGly: 7.701 ± 1.09
1.1AlaHis: 1.1 ± 0.312
3.961AlaIle: 3.961 ± 0.666
4.474AlaLys: 4.474 ± 0.92
8.215AlaLeu: 8.215 ± 0.954
3.154AlaMet: 3.154 ± 0.523
3.814AlaAsn: 3.814 ± 0.616
4.254AlaPro: 4.254 ± 0.478
4.914AlaGln: 4.914 ± 0.679
6.674AlaArg: 6.674 ± 0.698
6.674AlaSer: 6.674 ± 0.75
5.281AlaThr: 5.281 ± 1.083
5.281AlaVal: 5.281 ± 0.517
1.687AlaTrp: 1.687 ± 0.435
2.86AlaTyr: 2.86 ± 0.373
0.0AlaXaa: 0.0 ± 0.0
Cys
0.587CysAla: 0.587 ± 0.204
0.293CysCys: 0.293 ± 0.141
0.367CysAsp: 0.367 ± 0.153
0.88CysGlu: 0.88 ± 0.272
0.44CysPhe: 0.44 ± 0.168
1.247CysGly: 1.247 ± 0.313
0.147CysHis: 0.147 ± 0.104
0.293CysIle: 0.293 ± 0.153
0.513CysLys: 0.513 ± 0.189
1.1CysLeu: 1.1 ± 0.331
0.367CysMet: 0.367 ± 0.142
0.367CysAsn: 0.367 ± 0.215
0.733CysPro: 0.733 ± 0.263
0.44CysGln: 0.44 ± 0.211
0.733CysArg: 0.733 ± 0.241
0.44CysSer: 0.44 ± 0.181
1.1CysThr: 1.1 ± 0.384
0.587CysVal: 0.587 ± 0.222
0.147CysTrp: 0.147 ± 0.107
0.22CysTyr: 0.22 ± 0.12
0.0CysXaa: 0.0 ± 0.0
Asp
7.041AspAla: 7.041 ± 0.824
1.027AspCys: 1.027 ± 0.377
3.887AspAsp: 3.887 ± 0.454
4.327AspGlu: 4.327 ± 0.506
1.907AspPhe: 1.907 ± 0.304
5.794AspGly: 5.794 ± 1.293
1.027AspHis: 1.027 ± 0.381
3.374AspIle: 3.374 ± 0.364
1.98AspLys: 1.98 ± 0.369
4.694AspLeu: 4.694 ± 0.711
1.467AspMet: 1.467 ± 0.415
2.567AspAsn: 2.567 ± 0.367
5.208AspPro: 5.208 ± 0.88
3.374AspGln: 3.374 ± 0.457
3.447AspArg: 3.447 ± 0.575
2.787AspSer: 2.787 ± 0.426
2.787AspThr: 2.787 ± 0.351
4.254AspVal: 4.254 ± 0.559
1.247AspTrp: 1.247 ± 0.288
1.98AspTyr: 1.98 ± 0.316
0.0AspXaa: 0.0 ± 0.0
Glu
8.288GluAla: 8.288 ± 1.176
0.587GluCys: 0.587 ± 0.192
3.301GluAsp: 3.301 ± 0.373
3.961GluGlu: 3.961 ± 0.572
2.714GluPhe: 2.714 ± 0.354
4.474GluGly: 4.474 ± 0.687
0.807GluHis: 0.807 ± 0.279
2.714GluIle: 2.714 ± 0.486
2.934GluLys: 2.934 ± 0.483
6.528GluLeu: 6.528 ± 0.699
1.98GluMet: 1.98 ± 0.44
2.054GluAsn: 2.054 ± 0.365
3.227GluPro: 3.227 ± 0.563
3.887GluGln: 3.887 ± 0.583
3.667GluArg: 3.667 ± 0.547
2.787GluSer: 2.787 ± 0.463
3.594GluThr: 3.594 ± 0.627
4.547GluVal: 4.547 ± 0.555
1.54GluTrp: 1.54 ± 0.291
1.1GluTyr: 1.1 ± 0.237
0.0GluXaa: 0.0 ± 0.0
Phe
2.2PheAla: 2.2 ± 0.336
0.44PheCys: 0.44 ± 0.174
2.934PheAsp: 2.934 ± 0.489
2.054PheGlu: 2.054 ± 0.386
1.907PhePhe: 1.907 ± 0.455
2.567PheGly: 2.567 ± 0.372
0.66PheHis: 0.66 ± 0.2
1.174PheIle: 1.174 ± 0.292
1.834PheLys: 1.834 ± 0.355
2.64PheLeu: 2.64 ± 0.362
0.513PheMet: 0.513 ± 0.172
2.42PheAsn: 2.42 ± 0.591
1.32PhePro: 1.32 ± 0.336
1.76PheGln: 1.76 ± 0.331
1.76PheArg: 1.76 ± 0.443
2.567PheSer: 2.567 ± 0.441
2.567PheThr: 2.567 ± 0.521
2.127PheVal: 2.127 ± 0.488
0.807PheTrp: 0.807 ± 0.279
0.88PheTyr: 0.88 ± 0.207
0.0PheXaa: 0.0 ± 0.0
Gly
6.234GlyAla: 6.234 ± 0.692
1.174GlyCys: 1.174 ± 0.321
5.134GlyAsp: 5.134 ± 1.224
4.107GlyGlu: 4.107 ± 0.547
3.154GlyPhe: 3.154 ± 0.439
7.335GlyGly: 7.335 ± 1.366
0.953GlyHis: 0.953 ± 0.28
3.887GlyIle: 3.887 ± 0.541
4.181GlyLys: 4.181 ± 0.641
6.528GlyLeu: 6.528 ± 0.772
2.274GlyMet: 2.274 ± 0.446
4.181GlyAsn: 4.181 ± 0.649
3.594GlyPro: 3.594 ± 0.637
4.474GlyGln: 4.474 ± 0.693
3.961GlyArg: 3.961 ± 0.42
5.208GlySer: 5.208 ± 0.685
5.281GlyThr: 5.281 ± 1.166
5.134GlyVal: 5.134 ± 0.727
2.127GlyTrp: 2.127 ± 0.386
2.567GlyTyr: 2.567 ± 0.306
0.0GlyXaa: 0.0 ± 0.0
His
1.1HisAla: 1.1 ± 0.285
0.293HisCys: 0.293 ± 0.127
0.733HisAsp: 0.733 ± 0.326
1.1HisGlu: 1.1 ± 0.263
0.587HisPhe: 0.587 ± 0.206
0.953HisGly: 0.953 ± 0.201
0.147HisHis: 0.147 ± 0.118
0.733HisIle: 0.733 ± 0.251
0.44HisLys: 0.44 ± 0.147
1.907HisLeu: 1.907 ± 0.463
0.367HisMet: 0.367 ± 0.172
0.44HisAsn: 0.44 ± 0.173
0.513HisPro: 0.513 ± 0.149
0.587HisGln: 0.587 ± 0.205
0.587HisArg: 0.587 ± 0.223
0.513HisSer: 0.513 ± 0.172
0.953HisThr: 0.953 ± 0.298
1.1HisVal: 1.1 ± 0.398
0.367HisTrp: 0.367 ± 0.13
0.22HisTyr: 0.22 ± 0.155
0.0HisXaa: 0.0 ± 0.0
Ile
4.327IleAla: 4.327 ± 0.591
0.44IleCys: 0.44 ± 0.168
2.934IleAsp: 2.934 ± 0.474
3.594IleGlu: 3.594 ± 0.548
1.174IlePhe: 1.174 ± 0.349
3.227IleGly: 3.227 ± 0.505
0.22IleHis: 0.22 ± 0.116
1.027IleIle: 1.027 ± 0.229
2.714IleLys: 2.714 ± 0.454
2.494IleLeu: 2.494 ± 0.514
0.88IleMet: 0.88 ± 0.269
1.98IleAsn: 1.98 ± 0.306
2.274IlePro: 2.274 ± 0.524
3.007IleGln: 3.007 ± 0.6
3.374IleArg: 3.374 ± 0.4
3.007IleSer: 3.007 ± 0.523
3.007IleThr: 3.007 ± 0.673
1.907IleVal: 1.907 ± 0.411
1.027IleTrp: 1.027 ± 0.273
1.174IleTyr: 1.174 ± 0.241
0.0IleXaa: 0.0 ± 0.0
Lys
5.501LysAla: 5.501 ± 0.641
0.293LysCys: 0.293 ± 0.136
2.714LysAsp: 2.714 ± 0.468
2.934LysGlu: 2.934 ± 0.634
1.834LysPhe: 1.834 ± 0.391
3.081LysGly: 3.081 ± 0.494
1.174LysHis: 1.174 ± 0.301
2.64LysIle: 2.64 ± 0.406
2.2LysLys: 2.2 ± 0.559
3.961LysLeu: 3.961 ± 0.669
1.1LysMet: 1.1 ± 0.337
2.347LysAsn: 2.347 ± 0.375
3.007LysPro: 3.007 ± 0.376
2.274LysGln: 2.274 ± 0.422
1.76LysArg: 1.76 ± 0.3
1.834LysSer: 1.834 ± 0.364
2.347LysThr: 2.347 ± 0.417
2.567LysVal: 2.567 ± 0.493
1.394LysTrp: 1.394 ± 0.378
1.54LysTyr: 1.54 ± 0.302
0.0LysXaa: 0.0 ± 0.0
Leu
9.022LeuAla: 9.022 ± 0.995
0.807LeuCys: 0.807 ± 0.29
6.014LeuAsp: 6.014 ± 0.509
5.794LeuGlu: 5.794 ± 0.68
2.714LeuPhe: 2.714 ± 0.542
6.161LeuGly: 6.161 ± 0.687
1.1LeuHis: 1.1 ± 0.385
3.007LeuIle: 3.007 ± 0.33
3.301LeuLys: 3.301 ± 0.461
5.868LeuLeu: 5.868 ± 0.638
1.76LeuMet: 1.76 ± 0.395
4.034LeuAsn: 4.034 ± 0.384
4.254LeuPro: 4.254 ± 0.475
4.914LeuGln: 4.914 ± 0.625
4.474LeuArg: 4.474 ± 0.604
4.547LeuSer: 4.547 ± 0.554
4.547LeuThr: 4.547 ± 0.629
4.547LeuVal: 4.547 ± 0.47
0.88LeuTrp: 0.88 ± 0.268
2.347LeuTyr: 2.347 ± 0.521
0.0LeuXaa: 0.0 ± 0.0
Met
3.887MetAla: 3.887 ± 0.562
0.22MetCys: 0.22 ± 0.128
1.907MetAsp: 1.907 ± 0.381
1.614MetGlu: 1.614 ± 0.33
0.88MetPhe: 0.88 ± 0.404
2.567MetGly: 2.567 ± 0.381
0.147MetHis: 0.147 ± 0.106
1.027MetIle: 1.027 ± 0.277
1.174MetLys: 1.174 ± 0.244
1.834MetLeu: 1.834 ± 0.398
0.587MetMet: 0.587 ± 0.264
1.027MetAsn: 1.027 ± 0.279
1.467MetPro: 1.467 ± 0.253
1.687MetGln: 1.687 ± 0.335
1.834MetArg: 1.834 ± 0.477
1.54MetSer: 1.54 ± 0.388
1.907MetThr: 1.907 ± 0.421
1.027MetVal: 1.027 ± 0.283
0.073MetTrp: 0.073 ± 0.065
0.367MetTyr: 0.367 ± 0.147
0.0MetXaa: 0.0 ± 0.0
Asn
4.474AsnAla: 4.474 ± 0.696
0.66AsnCys: 0.66 ± 0.246
3.521AsnAsp: 3.521 ± 0.444
2.2AsnGlu: 2.2 ± 0.396
1.76AsnPhe: 1.76 ± 0.435
4.767AsnGly: 4.767 ± 0.829
0.587AsnHis: 0.587 ± 0.196
1.54AsnIle: 1.54 ± 0.348
2.42AsnLys: 2.42 ± 0.443
2.787AsnLeu: 2.787 ± 0.328
0.733AsnMet: 0.733 ± 0.28
1.54AsnAsn: 1.54 ± 0.417
1.98AsnPro: 1.98 ± 0.403
3.007AsnGln: 3.007 ± 0.497
3.227AsnArg: 3.227 ± 0.526
2.127AsnSer: 2.127 ± 0.305
2.787AsnThr: 2.787 ± 0.581
1.614AsnVal: 1.614 ± 0.366
1.1AsnTrp: 1.1 ± 0.366
1.54AsnTyr: 1.54 ± 0.282
0.0AsnXaa: 0.0 ± 0.0
Pro
3.081ProAla: 3.081 ± 0.581
1.027ProCys: 1.027 ± 0.294
4.547ProAsp: 4.547 ± 1.112
4.327ProGlu: 4.327 ± 0.927
1.174ProPhe: 1.174 ± 0.297
4.694ProGly: 4.694 ± 0.819
0.66ProHis: 0.66 ± 0.268
1.98ProIle: 1.98 ± 0.365
2.494ProLys: 2.494 ± 0.416
3.741ProLeu: 3.741 ± 0.401
1.247ProMet: 1.247 ± 0.263
2.934ProAsn: 2.934 ± 0.368
2.2ProPro: 2.2 ± 0.465
2.054ProGln: 2.054 ± 0.472
2.274ProArg: 2.274 ± 0.465
2.86ProSer: 2.86 ± 0.438
3.081ProThr: 3.081 ± 0.445
3.741ProVal: 3.741 ± 0.483
1.1ProTrp: 1.1 ± 0.256
1.32ProTyr: 1.32 ± 0.362
0.0ProXaa: 0.0 ± 0.0
Gln
6.014GlnAla: 6.014 ± 0.798
0.367GlnCys: 0.367 ± 0.136
2.42GlnAsp: 2.42 ± 0.458
3.154GlnGlu: 3.154 ± 0.479
2.42GlnPhe: 2.42 ± 0.291
3.667GlnGly: 3.667 ± 0.364
0.367GlnHis: 0.367 ± 0.175
2.86GlnIle: 2.86 ± 0.447
2.347GlnLys: 2.347 ± 0.731
5.794GlnLeu: 5.794 ± 0.728
2.054GlnMet: 2.054 ± 0.502
1.907GlnAsn: 1.907 ± 0.407
2.787GlnPro: 2.787 ± 0.381
4.181GlnGln: 4.181 ± 0.862
3.594GlnArg: 3.594 ± 0.6
2.714GlnSer: 2.714 ± 0.304
2.567GlnThr: 2.567 ± 0.516
2.714GlnVal: 2.714 ± 0.524
1.1GlnTrp: 1.1 ± 0.329
1.394GlnTyr: 1.394 ± 0.361
0.0GlnXaa: 0.0 ± 0.0
Arg
5.868ArgAla: 5.868 ± 0.701
0.293ArgCys: 0.293 ± 0.187
2.787ArgAsp: 2.787 ± 0.396
2.934ArgGlu: 2.934 ± 0.511
2.054ArgPhe: 2.054 ± 0.349
4.034ArgGly: 4.034 ± 0.576
1.027ArgHis: 1.027 ± 0.306
3.081ArgIle: 3.081 ± 0.435
2.054ArgLys: 2.054 ± 0.384
5.574ArgLeu: 5.574 ± 0.798
1.98ArgMet: 1.98 ± 0.396
2.787ArgAsn: 2.787 ± 0.454
2.127ArgPro: 2.127 ± 0.403
3.594ArgGln: 3.594 ± 0.531
4.401ArgArg: 4.401 ± 0.855
3.374ArgSer: 3.374 ± 0.595
3.081ArgThr: 3.081 ± 0.426
5.281ArgVal: 5.281 ± 0.556
1.027ArgTrp: 1.027 ± 0.23
2.054ArgTyr: 2.054 ± 0.324
0.0ArgXaa: 0.0 ± 0.0
Ser
5.281SerAla: 5.281 ± 0.877
0.367SerCys: 0.367 ± 0.16
3.007SerAsp: 3.007 ± 0.464
3.301SerGlu: 3.301 ± 0.6
2.42SerPhe: 2.42 ± 0.4
5.134SerGly: 5.134 ± 0.489
0.807SerHis: 0.807 ± 0.195
2.567SerIle: 2.567 ± 0.434
3.521SerLys: 3.521 ± 0.582
3.887SerLeu: 3.887 ± 0.455
1.247SerMet: 1.247 ± 0.333
3.007SerAsn: 3.007 ± 0.493
2.64SerPro: 2.64 ± 0.399
2.494SerGln: 2.494 ± 0.532
3.301SerArg: 3.301 ± 0.457
3.521SerSer: 3.521 ± 0.536
3.007SerThr: 3.007 ± 0.326
4.181SerVal: 4.181 ± 0.628
1.687SerTrp: 1.687 ± 0.261
1.54SerTyr: 1.54 ± 0.267
0.0SerXaa: 0.0 ± 0.0
Thr
6.088ThrAla: 6.088 ± 1.086
0.953ThrCys: 0.953 ± 0.362
3.814ThrAsp: 3.814 ± 0.748
3.961ThrGlu: 3.961 ± 0.553
1.907ThrPhe: 1.907 ± 0.422
5.574ThrGly: 5.574 ± 0.7
0.88ThrHis: 0.88 ± 0.325
3.521ThrIle: 3.521 ± 0.898
2.86ThrLys: 2.86 ± 0.436
4.474ThrLeu: 4.474 ± 0.738
0.807ThrMet: 0.807 ± 0.255
1.907ThrAsn: 1.907 ± 0.509
4.034ThrPro: 4.034 ± 0.599
2.714ThrGln: 2.714 ± 0.513
2.714ThrArg: 2.714 ± 0.366
3.374ThrSer: 3.374 ± 0.712
3.887ThrThr: 3.887 ± 0.825
3.227ThrVal: 3.227 ± 0.681
1.174ThrTrp: 1.174 ± 0.358
1.687ThrTyr: 1.687 ± 0.5
0.0ThrXaa: 0.0 ± 0.0
Val
5.061ValAla: 5.061 ± 0.877
0.66ValCys: 0.66 ± 0.195
4.694ValAsp: 4.694 ± 0.715
3.741ValGlu: 3.741 ± 0.581
1.907ValPhe: 1.907 ± 0.303
5.134ValGly: 5.134 ± 0.74
1.027ValHis: 1.027 ± 0.261
2.494ValIle: 2.494 ± 0.363
2.42ValLys: 2.42 ± 0.373
4.254ValLeu: 4.254 ± 0.683
2.274ValMet: 2.274 ± 0.376
2.86ValAsn: 2.86 ± 0.453
3.154ValPro: 3.154 ± 0.463
2.494ValGln: 2.494 ± 0.44
3.741ValArg: 3.741 ± 0.604
4.034ValSer: 4.034 ± 0.584
4.988ValThr: 4.988 ± 1.305
3.961ValVal: 3.961 ± 0.699
0.807ValTrp: 0.807 ± 0.248
1.32ValTyr: 1.32 ± 0.279
0.0ValXaa: 0.0 ± 0.0
Trp
1.687TrpAla: 1.687 ± 0.292
0.147TrpCys: 0.147 ± 0.112
1.687TrpAsp: 1.687 ± 0.311
0.953TrpGlu: 0.953 ± 0.255
0.513TrpPhe: 0.513 ± 0.201
0.807TrpGly: 0.807 ± 0.19
0.367TrpHis: 0.367 ± 0.143
1.027TrpIle: 1.027 ± 0.328
0.807TrpLys: 0.807 ± 0.24
1.76TrpLeu: 1.76 ± 0.31
0.733TrpMet: 0.733 ± 0.214
1.54TrpAsn: 1.54 ± 0.509
0.587TrpPro: 0.587 ± 0.206
1.247TrpGln: 1.247 ± 0.284
1.54TrpArg: 1.54 ± 0.371
1.614TrpSer: 1.614 ± 0.458
1.1TrpThr: 1.1 ± 0.355
1.174TrpVal: 1.174 ± 0.291
0.44TrpTrp: 0.44 ± 0.196
0.293TrpTyr: 0.293 ± 0.122
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.76TyrAla: 1.76 ± 0.447
0.293TyrCys: 0.293 ± 0.142
1.834TyrAsp: 1.834 ± 0.322
1.687TyrGlu: 1.687 ± 0.279
0.953TyrPhe: 0.953 ± 0.271
2.567TyrGly: 2.567 ± 0.519
0.44TyrHis: 0.44 ± 0.181
0.88TyrIle: 0.88 ± 0.222
1.834TyrLys: 1.834 ± 0.36
2.054TyrLeu: 2.054 ± 0.385
1.174TyrMet: 1.174 ± 0.284
0.66TyrAsn: 0.66 ± 0.254
1.174TyrPro: 1.174 ± 0.237
1.32TyrGln: 1.32 ± 0.347
2.347TyrArg: 2.347 ± 0.466
1.394TyrSer: 1.394 ± 0.4
1.687TyrThr: 1.687 ± 0.408
2.054TyrVal: 2.054 ± 0.389
0.293TyrTrp: 0.293 ± 0.142
0.807TyrTyr: 0.807 ± 0.214
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 43 proteins (13635 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski