Amino acid dipepetide frequency for Sphingobium cloacae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.746AlaAla: 18.746 ± 0.17	1.087AlaCys: 1.087 ± 0.033	7.608AlaAsp: 7.608 ± 0.091	7.564AlaGlu: 7.564 ± 0.098	4.313AlaPhe: 4.313 ± 0.062	11.016AlaGly: 11.016 ± 0.102	2.478AlaHis: 2.478 ± 0.054	6.8AlaIle: 6.8 ± 0.071	3.981AlaLys: 3.981 ± 0.067	14.149AlaLeu: 14.149 ± 0.138	4.033AlaMet: 4.033 ± 0.061	2.928AlaAsn: 2.928 ± 0.053	6.138AlaPro: 6.138 ± 0.092	4.737AlaGln: 4.737 ± 0.071	10.293AlaArg: 10.293 ± 0.103	6.59AlaSer: 6.59 ± 0.072	6.018AlaThr: 6.018 ± 0.07	8.439AlaVal: 8.439 ± 0.093	1.658AlaTrp: 1.658 ± 0.041	2.583AlaTyr: 2.583 ± 0.045	0.0AlaXaa: 0.0 ± 0.0
Cys	1.04CysAla: 1.04 ± 0.036	0.108CysCys: 0.108 ± 0.011	0.49CysAsp: 0.49 ± 0.02	0.413CysGlu: 0.413 ± 0.019	0.282CysPhe: 0.282 ± 0.015	0.794CysGly: 0.794 ± 0.026	0.222CysHis: 0.222 ± 0.015	0.354CysIle: 0.354 ± 0.016	0.185CysLys: 0.185 ± 0.012	0.724CysLeu: 0.724 ± 0.026	0.15CysMet: 0.15 ± 0.011	0.18CysAsn: 0.18 ± 0.013	0.456CysPro: 0.456 ± 0.019	0.198CysGln: 0.198 ± 0.012	0.577CysArg: 0.577 ± 0.018	0.437CysSer: 0.437 ± 0.022	0.367CysThr: 0.367 ± 0.018	0.521CysVal: 0.521 ± 0.02	0.141CysTrp: 0.141 ± 0.011	0.176CysTyr: 0.176 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	7.574AspAla: 7.574 ± 0.093	0.45AspCys: 0.45 ± 0.02	3.273AspAsp: 3.273 ± 0.05	3.489AspGlu: 3.489 ± 0.062	2.214AspPhe: 2.214 ± 0.039	5.569AspGly: 5.569 ± 0.074	1.459AspHis: 1.459 ± 0.043	3.111AspIle: 3.111 ± 0.048	1.711AspLys: 1.711 ± 0.046	5.915AspLeu: 5.915 ± 0.071	1.624AspMet: 1.624 ± 0.04	1.341AspAsn: 1.341 ± 0.036	3.746AspPro: 3.746 ± 0.055	1.834AspGln: 1.834 ± 0.038	5.26AspArg: 5.26 ± 0.068	2.393AspSer: 2.393 ± 0.042	2.372AspThr: 2.372 ± 0.046	3.877AspVal: 3.877 ± 0.056	1.072AspTrp: 1.072 ± 0.031	1.656AspTyr: 1.656 ± 0.039	0.0AspXaa: 0.0 ± 0.0
Glu	7.99GluAla: 7.99 ± 0.091	0.333GluCys: 0.333 ± 0.015	2.868GluAsp: 2.868 ± 0.045	3.278GluGlu: 3.278 ± 0.07	1.377GluPhe: 1.377 ± 0.032	4.762GluGly: 4.762 ± 0.066	1.144GluHis: 1.144 ± 0.027	3.097GluIle: 3.097 ± 0.054	2.271GluLys: 2.271 ± 0.044	4.919GluLeu: 4.919 ± 0.059	1.493GluMet: 1.493 ± 0.035	1.421GluAsn: 1.421 ± 0.036	2.552GluPro: 2.552 ± 0.049	2.205GluGln: 2.205 ± 0.042	5.392GluArg: 5.392 ± 0.08	2.362GluSer: 2.362 ± 0.047	3.126GluThr: 3.126 ± 0.045	3.395GluVal: 3.395 ± 0.058	0.766GluTrp: 0.766 ± 0.023	0.957GluTyr: 0.957 ± 0.027	0.0GluXaa: 0.0 ± 0.0
Phe	4.614PheAla: 4.614 ± 0.066	0.308PheCys: 0.308 ± 0.015	2.557PheAsp: 2.557 ± 0.053	1.998PheGlu: 1.998 ± 0.04	1.28PhePhe: 1.28 ± 0.037	3.421PheGly: 3.421 ± 0.054	0.74PheHis: 0.74 ± 0.024	1.444PheIle: 1.444 ± 0.035	0.845PheLys: 0.845 ± 0.027	3.214PheLeu: 3.214 ± 0.058	0.778PheMet: 0.778 ± 0.025	0.964PheAsn: 0.964 ± 0.034	1.46PhePro: 1.46 ± 0.036	0.927PheGln: 0.927 ± 0.024	2.341PheArg: 2.341 ± 0.042	2.078PheSer: 2.078 ± 0.039	1.897PheThr: 1.897 ± 0.041	2.422PheVal: 2.422 ± 0.046	0.531PheTrp: 0.531 ± 0.022	0.86PheTyr: 0.86 ± 0.028	0.0PheXaa: 0.0 ± 0.0
Gly	9.71GlyAla: 9.71 ± 0.1	0.757GlyCys: 0.757 ± 0.026	4.896GlyAsp: 4.896 ± 0.073	4.972GlyGlu: 4.972 ± 0.068	3.446GlyPhe: 3.446 ± 0.052	7.675GlyGly: 7.675 ± 0.112	1.938GlyHis: 1.938 ± 0.039	4.482GlyIle: 4.482 ± 0.056	3.415GlyLys: 3.415 ± 0.065	8.5GlyLeu: 8.5 ± 0.096	2.435GlyMet: 2.435 ± 0.044	2.173GlyAsn: 2.173 ± 0.054	3.517GlyPro: 3.517 ± 0.058	3.213GlyGln: 3.213 ± 0.052	6.81GlyArg: 6.81 ± 0.079	4.652GlySer: 4.652 ± 0.066	4.557GlyThr: 4.557 ± 0.072	5.997GlyVal: 5.997 ± 0.08	1.562GlyTrp: 1.562 ± 0.041	2.253GlyTyr: 2.253 ± 0.044	0.0GlyXaa: 0.0 ± 0.0
His	2.509HisAla: 2.509 ± 0.049	0.214HisCys: 0.214 ± 0.013	1.283HisAsp: 1.283 ± 0.031	1.068HisGlu: 1.068 ± 0.031	0.84HisPhe: 0.84 ± 0.024	2.114HisGly: 2.114 ± 0.046	0.603HisHis: 0.603 ± 0.026	1.006HisIle: 1.006 ± 0.031	0.472HisLys: 0.472 ± 0.018	2.025HisLeu: 2.025 ± 0.042	0.498HisMet: 0.498 ± 0.02	0.435HisAsn: 0.435 ± 0.018	1.334HisPro: 1.334 ± 0.032	0.597HisGln: 0.597 ± 0.022	1.607HisArg: 1.607 ± 0.039	0.947HisSer: 0.947 ± 0.028	0.58HisThr: 0.58 ± 0.023	1.617HisVal: 1.617 ± 0.034	0.39HisTrp: 0.39 ± 0.019	0.595HisTyr: 0.595 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	7.818IleAla: 7.818 ± 0.079	0.437IleCys: 0.437 ± 0.017	3.903IleAsp: 3.903 ± 0.059	3.459IleGlu: 3.459 ± 0.055	1.648IlePhe: 1.648 ± 0.041	4.993IleGly: 4.993 ± 0.072	0.941IleHis: 0.941 ± 0.031	2.039IleIle: 2.039 ± 0.047	1.199IleLys: 1.199 ± 0.029	4.336IleLeu: 4.336 ± 0.068	0.969IleMet: 0.969 ± 0.031	1.246IleAsn: 1.246 ± 0.035	2.339IlePro: 2.339 ± 0.044	1.189IleGln: 1.189 ± 0.027	3.464IleArg: 3.464 ± 0.057	2.703IleSer: 2.703 ± 0.045	2.327IleThr: 2.327 ± 0.047	4.23IleVal: 4.23 ± 0.063	0.616IleTrp: 0.616 ± 0.026	1.011IleTyr: 1.011 ± 0.034	0.0IleXaa: 0.0 ± 0.0
Lys	4.351LysAla: 4.351 ± 0.076	0.15LysCys: 0.15 ± 0.01	1.714LysAsp: 1.714 ± 0.041	1.462LysGlu: 1.462 ± 0.04	0.696LysPhe: 0.696 ± 0.025	2.905LysGly: 2.905 ± 0.054	0.539LysHis: 0.539 ± 0.022	1.425LysIle: 1.425 ± 0.037	1.123LysLys: 1.123 ± 0.041	3.183LysLeu: 3.183 ± 0.06	0.757LysMet: 0.757 ± 0.026	0.709LysAsn: 0.709 ± 0.027	2.015LysPro: 2.015 ± 0.045	0.964LysGln: 0.964 ± 0.03	2.407LysArg: 2.407 ± 0.046	1.643LysSer: 1.643 ± 0.038	1.641LysThr: 1.641 ± 0.039	2.199LysVal: 2.199 ± 0.053	0.407LysTrp: 0.407 ± 0.019	0.562LysTyr: 0.562 ± 0.017	0.0LysXaa: 0.0 ± 0.0
Leu	13.726LeuAla: 13.726 ± 0.137	0.901LeuCys: 0.901 ± 0.029	6.198LeuAsp: 6.198 ± 0.076	5.106LeuGlu: 5.106 ± 0.075	3.807LeuPhe: 3.807 ± 0.06	8.107LeuGly: 8.107 ± 0.093	1.975LeuHis: 1.975 ± 0.04	4.985LeuIle: 4.985 ± 0.08	3.122LeuLys: 3.122 ± 0.052	10.007LeuLeu: 10.007 ± 0.125	2.271LeuMet: 2.271 ± 0.043	2.371LeuAsn: 2.371 ± 0.041	5.715LeuPro: 5.715 ± 0.075	2.525LeuGln: 2.525 ± 0.045	7.413LeuArg: 7.413 ± 0.092	6.435LeuSer: 6.435 ± 0.07	5.564LeuThr: 5.564 ± 0.065	6.778LeuVal: 6.778 ± 0.081	1.295LeuTrp: 1.295 ± 0.034	2.01LeuTyr: 2.01 ± 0.04	0.0LeuXaa: 0.0 ± 0.0
Met	3.655MetAla: 3.655 ± 0.053	0.148MetCys: 0.148 ± 0.01	1.242MetAsp: 1.242 ± 0.032	1.275MetGlu: 1.275 ± 0.036	0.635MetPhe: 0.635 ± 0.024	2.025MetGly: 2.025 ± 0.045	0.471MetHis: 0.471 ± 0.017	1.389MetIle: 1.389 ± 0.029	0.983MetLys: 0.983 ± 0.027	2.74MetLeu: 2.74 ± 0.05	0.729MetMet: 0.729 ± 0.026	0.705MetAsn: 0.705 ± 0.022	1.568MetPro: 1.568 ± 0.039	0.804MetGln: 0.804 ± 0.026	1.909MetArg: 1.909 ± 0.038	1.499MetSer: 1.499 ± 0.037	1.738MetThr: 1.738 ± 0.038	1.632MetVal: 1.632 ± 0.038	0.208MetTrp: 0.208 ± 0.013	0.235MetTyr: 0.235 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	3.16AsnAla: 3.16 ± 0.046	0.203AsnCys: 0.203 ± 0.014	1.372AsnAsp: 1.372 ± 0.032	1.12AsnGlu: 1.12 ± 0.033	0.83AsnPhe: 0.83 ± 0.027	2.305AsnGly: 2.305 ± 0.052	0.435AsnHis: 0.435 ± 0.021	1.296AsnIle: 1.296 ± 0.041	0.639AsnLys: 0.639 ± 0.023	2.427AsnLeu: 2.427 ± 0.046	0.585AsnMet: 0.585 ± 0.021	0.622AsnAsn: 0.622 ± 0.027	1.681AsnPro: 1.681 ± 0.042	0.762AsnGln: 0.762 ± 0.023	1.969AsnArg: 1.969 ± 0.041	1.163AsnSer: 1.163 ± 0.033	0.917AsnThr: 0.917 ± 0.028	1.794AsnVal: 1.794 ± 0.043	0.41AsnTrp: 0.41 ± 0.02	0.631AsnTyr: 0.631 ± 0.025	0.0AsnXaa: 0.0 ± 0.0
Pro	7.079ProAla: 7.079 ± 0.09	0.343ProCys: 0.343 ± 0.019	3.875ProAsp: 3.875 ± 0.056	3.428ProGlu: 3.428 ± 0.054	1.911ProPhe: 1.911 ± 0.037	4.621ProGly: 4.621 ± 0.062	1.079ProHis: 1.079 ± 0.03	2.419ProIle: 2.419 ± 0.044	1.458ProLys: 1.458 ± 0.041	4.92ProLeu: 4.92 ± 0.07	1.276ProMet: 1.276 ± 0.035	1.12ProAsn: 1.12 ± 0.03	3.039ProPro: 3.039 ± 0.087	1.742ProGln: 1.742 ± 0.035	3.293ProArg: 3.293 ± 0.058	2.748ProSer: 2.748 ± 0.049	2.343ProThr: 2.343 ± 0.044	4.349ProVal: 4.349 ± 0.062	0.727ProTrp: 0.727 ± 0.024	1.065ProTyr: 1.065 ± 0.025	0.0ProXaa: 0.0 ± 0.0
Gln	4.506GlnAla: 4.506 ± 0.076	0.225GlnCys: 0.225 ± 0.013	1.534GlnAsp: 1.534 ± 0.035	1.484GlnGlu: 1.484 ± 0.032	1.033GlnPhe: 1.033 ± 0.028	2.614GlnGly: 2.614 ± 0.044	0.607GlnHis: 0.607 ± 0.022	1.824GlnIle: 1.824 ± 0.043	1.026GlnLys: 1.026 ± 0.03	3.072GlnLeu: 3.072 ± 0.062	0.866GlnMet: 0.866 ± 0.029	0.775GlnAsn: 0.775 ± 0.025	1.835GlnPro: 1.835 ± 0.036	1.243GlnGln: 1.243 ± 0.039	2.782GlnArg: 2.782 ± 0.051	1.874GlnSer: 1.874 ± 0.042	1.565GlnThr: 1.565 ± 0.035	2.268GlnVal: 2.268 ± 0.049	0.49GlnTrp: 0.49 ± 0.021	0.647GlnTyr: 0.647 ± 0.022	0.0GlnXaa: 0.0 ± 0.0
Arg	9.166ArgAla: 9.166 ± 0.094	0.531ArgCys: 0.531 ± 0.02	4.664ArgAsp: 4.664 ± 0.068	4.311ArgGlu: 4.311 ± 0.071	3.211ArgPhe: 3.211 ± 0.053	5.173ArgGly: 5.173 ± 0.071	1.958ArgHis: 1.958 ± 0.038	4.417ArgIle: 4.417 ± 0.067	2.523ArgLys: 2.523 ± 0.05	8.883ArgLeu: 8.883 ± 0.1	2.115ArgMet: 2.115 ± 0.039	1.919ArgAsn: 1.919 ± 0.042	3.99ArgPro: 3.99 ± 0.065	2.963ArgGln: 2.963 ± 0.06	6.475ArgArg: 6.475 ± 0.095	4.029ArgSer: 4.029 ± 0.064	3.697ArgThr: 3.697 ± 0.055	4.722ArgVal: 4.722 ± 0.061	1.298ArgTrp: 1.298 ± 0.036	1.971ArgTyr: 1.971 ± 0.04	0.0ArgXaa: 0.0 ± 0.0
Ser	6.421SerAla: 6.421 ± 0.081	0.437SerCys: 0.437 ± 0.02	3.107SerAsp: 3.107 ± 0.053	2.669SerGlu: 2.669 ± 0.046	2.161SerPhe: 2.161 ± 0.04	5.462SerGly: 5.462 ± 0.07	1.034SerHis: 1.034 ± 0.027	2.77SerIle: 2.77 ± 0.04	1.424SerLys: 1.424 ± 0.037	5.346SerLeu: 5.346 ± 0.066	1.313SerMet: 1.313 ± 0.033	1.311SerAsn: 1.311 ± 0.033	2.888SerPro: 2.888 ± 0.053	1.523SerGln: 1.523 ± 0.036	3.898SerArg: 3.898 ± 0.06	2.814SerSer: 2.814 ± 0.058	2.528SerThr: 2.528 ± 0.046	3.612SerVal: 3.612 ± 0.061	0.778SerTrp: 0.778 ± 0.025	1.319SerTyr: 1.319 ± 0.035	0.0SerXaa: 0.0 ± 0.0
Thr	5.856ThrAla: 5.856 ± 0.069	0.322ThrCys: 0.322 ± 0.016	2.85ThrAsp: 2.85 ± 0.047	2.23ThrGlu: 2.23 ± 0.043	1.683ThrPhe: 1.683 ± 0.041	5.155ThrGly: 5.155 ± 0.078	0.948ThrHis: 0.948 ± 0.029	2.861ThrIle: 2.861 ± 0.052	1.242ThrLys: 1.242 ± 0.035	5.665ThrLeu: 5.665 ± 0.078	1.168ThrMet: 1.168 ± 0.032	1.142ThrAsn: 1.142 ± 0.029	3.18ThrPro: 3.18 ± 0.053	1.479ThrGln: 1.479 ± 0.031	3.394ThrArg: 3.394 ± 0.055	2.463ThrSer: 2.463 ± 0.045	2.448ThrThr: 2.448 ± 0.054	4.045ThrVal: 4.045 ± 0.07	0.588ThrTrp: 0.588 ± 0.024	1.078ThrTyr: 1.078 ± 0.03	0.0ThrXaa: 0.0 ± 0.0
Val	9.186ValAla: 9.186 ± 0.094	0.509ValCys: 0.509 ± 0.022	4.253ValAsp: 4.253 ± 0.059	4.627ValGlu: 4.627 ± 0.064	2.003ValPhe: 2.003 ± 0.042	5.263ValGly: 5.263 ± 0.074	1.352ValHis: 1.352 ± 0.035	3.558ValIle: 3.558 ± 0.059	2.177ValLys: 2.177 ± 0.047	6.307ValLeu: 6.307 ± 0.081	1.703ValMet: 1.703 ± 0.037	1.896ValAsn: 1.896 ± 0.049	3.696ValPro: 3.696 ± 0.06	2.088ValGln: 2.088 ± 0.043	5.308ValArg: 5.308 ± 0.069	3.956ValSer: 3.956 ± 0.059	4.313ValThr: 4.313 ± 0.069	4.934ValVal: 4.934 ± 0.068	0.744ValTrp: 0.744 ± 0.026	1.358ValTyr: 1.358 ± 0.033	0.0ValXaa: 0.0 ± 0.0
Trp	1.397TrpAla: 1.397 ± 0.037	0.119TrpCys: 0.119 ± 0.009	0.71TrpAsp: 0.71 ± 0.025	0.608TrpGlu: 0.608 ± 0.025	0.539TrpPhe: 0.539 ± 0.018	0.879TrpGly: 0.879 ± 0.023	0.347TrpHis: 0.347 ± 0.015	0.744TrpIle: 0.744 ± 0.024	0.49TrpLys: 0.49 ± 0.019	1.81TrpLeu: 1.81 ± 0.047	0.388TrpMet: 0.388 ± 0.015	0.482TrpAsn: 0.482 ± 0.019	0.702TrpPro: 0.702 ± 0.022	0.573TrpGln: 0.573 ± 0.022	1.418TrpArg: 1.418 ± 0.033	0.874TrpSer: 0.874 ± 0.028	0.824TrpThr: 0.824 ± 0.021	0.835TrpVal: 0.835 ± 0.029	0.239TrpTrp: 0.239 ± 0.013	0.288TrpTyr: 0.288 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.651TyrAla: 2.651 ± 0.047	0.232TyrCys: 0.232 ± 0.013	1.544TyrAsp: 1.544 ± 0.035	1.147TyrGlu: 1.147 ± 0.033	0.773TyrPhe: 0.773 ± 0.027	2.108TyrGly: 2.108 ± 0.045	0.467TyrHis: 0.467 ± 0.019	0.846TyrIle: 0.846 ± 0.025	0.567TyrLys: 0.567 ± 0.021	2.166TyrLeu: 2.166 ± 0.045	0.437TyrMet: 0.437 ± 0.02	0.581TyrAsn: 0.581 ± 0.024	0.983TyrPro: 0.983 ± 0.029	0.702TyrGln: 0.702 ± 0.029	2.007TyrArg: 2.007 ± 0.041	1.157TyrSer: 1.157 ± 0.031	0.974TyrThr: 0.974 ± 0.028	1.565TyrVal: 1.565 ± 0.038	0.346TyrTrp: 0.346 ± 0.016	0.574TyrTyr: 0.574 ± 0.025	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3852 proteins (1264410 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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