Amino acid dipepetide frequency for Sodalis endosymbiont of Henestaris halophilus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.164AlaAla: 7.164 ± 0.223
1.185AlaCys: 1.185 ± 0.08
3.923AlaAsp: 3.923 ± 0.142
4.471AlaGlu: 4.471 ± 0.152
2.649AlaPhe: 2.649 ± 0.104
5.481AlaGly: 5.481 ± 0.19
1.658AlaHis: 1.658 ± 0.09
6.104AlaIle: 6.104 ± 0.189
4.077AlaLys: 4.077 ± 0.132
9.559AlaLeu: 9.559 ± 0.217
2.624AlaMet: 2.624 ± 0.114
3.171AlaAsn: 3.171 ± 0.126
2.629AlaPro: 2.629 ± 0.098
3.395AlaGln: 3.395 ± 0.129
4.919AlaArg: 4.919 ± 0.162
4.615AlaSer: 4.615 ± 0.146
4.182AlaThr: 4.182 ± 0.14
5.77AlaVal: 5.77 ± 0.181
0.846AlaTrp: 0.846 ± 0.062
2.195AlaTyr: 2.195 ± 0.1
0.0AlaXaa: 0.0 ± 0.0
Cys
0.916CysAla: 0.916 ± 0.069
0.294CysCys: 0.294 ± 0.04
0.787CysAsp: 0.787 ± 0.062
0.573CysGlu: 0.573 ± 0.054
0.577CysPhe: 0.577 ± 0.047
1.145CysGly: 1.145 ± 0.08
0.393CysHis: 0.393 ± 0.044
0.951CysIle: 0.951 ± 0.073
0.692CysLys: 0.692 ± 0.06
1.309CysLeu: 1.309 ± 0.081
0.373CysMet: 0.373 ± 0.044
0.568CysAsn: 0.568 ± 0.051
0.508CysPro: 0.508 ± 0.049
0.692CysGln: 0.692 ± 0.063
0.737CysArg: 0.737 ± 0.05
0.946CysSer: 0.946 ± 0.067
0.667CysThr: 0.667 ± 0.066
0.762CysVal: 0.762 ± 0.063
0.214CysTrp: 0.214 ± 0.032
0.513CysTyr: 0.513 ± 0.047
0.0CysXaa: 0.0 ± 0.0
Asp
3.749AspAla: 3.749 ± 0.129
0.672AspCys: 0.672 ± 0.061
2.34AspAsp: 2.34 ± 0.107
2.698AspGlu: 2.698 ± 0.104
2.071AspPhe: 2.071 ± 0.095
3.316AspGly: 3.316 ± 0.133
1.065AspHis: 1.065 ± 0.064
4.361AspIle: 4.361 ± 0.151
2.828AspLys: 2.828 ± 0.108
5.043AspLeu: 5.043 ± 0.151
1.449AspMet: 1.449 ± 0.083
2.4AspAsn: 2.4 ± 0.107
1.966AspPro: 1.966 ± 0.104
1.628AspGln: 1.628 ± 0.088
2.683AspArg: 2.683 ± 0.099
2.619AspSer: 2.619 ± 0.094
2.484AspThr: 2.484 ± 0.114
3.898AspVal: 3.898 ± 0.164
0.652AspTrp: 0.652 ± 0.052
1.986AspTyr: 1.986 ± 0.093
0.0AspXaa: 0.0 ± 0.0
Glu
4.5GluAla: 4.5 ± 0.175
0.622GluCys: 0.622 ± 0.053
2.25GluAsp: 2.25 ± 0.105
3.276GluGlu: 3.276 ± 0.152
1.747GluPhe: 1.747 ± 0.088
3.037GluGly: 3.037 ± 0.12
1.414GluHis: 1.414 ± 0.086
4.028GluIle: 4.028 ± 0.162
3.326GluLys: 3.326 ± 0.163
5.745GluLeu: 5.745 ± 0.192
1.598GluMet: 1.598 ± 0.086
2.235GluAsn: 2.235 ± 0.105
1.558GluPro: 1.558 ± 0.085
2.778GluGln: 2.778 ± 0.127
3.644GluArg: 3.644 ± 0.141
2.534GluSer: 2.534 ± 0.11
2.4GluThr: 2.4 ± 0.102
3.873GluVal: 3.873 ± 0.164
0.443GluTrp: 0.443 ± 0.046
1.334GluTyr: 1.334 ± 0.085
0.0GluXaa: 0.0 ± 0.0
Phe
2.858PheAla: 2.858 ± 0.129
0.821PheCys: 0.821 ± 0.066
2.245PheAsp: 2.245 ± 0.108
1.678PheGlu: 1.678 ± 0.097
1.608PhePhe: 1.608 ± 0.112
2.693PheGly: 2.693 ± 0.125
0.831PheHis: 0.831 ± 0.063
3.221PheIle: 3.221 ± 0.16
1.563PheLys: 1.563 ± 0.084
3.555PheLeu: 3.555 ± 0.155
1.05PheMet: 1.05 ± 0.073
2.041PheAsn: 2.041 ± 0.103
1.419PhePro: 1.419 ± 0.086
1.12PheGln: 1.12 ± 0.078
1.907PheArg: 1.907 ± 0.086
3.047PheSer: 3.047 ± 0.145
2.041PheThr: 2.041 ± 0.107
2.355PheVal: 2.355 ± 0.115
0.393PheTrp: 0.393 ± 0.049
1.374PheTyr: 1.374 ± 0.086
0.0PheXaa: 0.0 ± 0.0
Gly
4.829GlyAla: 4.829 ± 0.174
0.961GlyCys: 0.961 ± 0.072
3.525GlyAsp: 3.525 ± 0.152
3.584GlyGlu: 3.584 ± 0.136
2.768GlyPhe: 2.768 ± 0.125
4.565GlyGly: 4.565 ± 0.174
1.802GlyHis: 1.802 ± 0.091
5.521GlyIle: 5.521 ± 0.178
4.376GlyLys: 4.376 ± 0.151
6.651GlyLeu: 6.651 ± 0.213
2.056GlyMet: 2.056 ± 0.108
2.733GlyAsn: 2.733 ± 0.136
1.782GlyPro: 1.782 ± 0.099
2.624GlyGln: 2.624 ± 0.128
3.803GlyArg: 3.803 ± 0.138
3.868GlySer: 3.868 ± 0.145
3.43GlyThr: 3.43 ± 0.129
5.038GlyVal: 5.038 ± 0.163
0.851GlyTrp: 0.851 ± 0.073
2.265GlyTyr: 2.265 ± 0.103
0.0GlyXaa: 0.0 ± 0.0
His
1.937HisAla: 1.937 ± 0.094
0.388HisCys: 0.388 ± 0.042
1.105HisAsp: 1.105 ± 0.072
1.085HisGlu: 1.085 ± 0.073
1.18HisPhe: 1.18 ± 0.082
1.767HisGly: 1.767 ± 0.097
0.757HisHis: 0.757 ± 0.072
1.877HisIle: 1.877 ± 0.097
1.17HisLys: 1.17 ± 0.076
2.544HisLeu: 2.544 ± 0.104
0.662HisMet: 0.662 ± 0.062
1.085HisAsn: 1.085 ± 0.084
1.329HisPro: 1.329 ± 0.078
1.265HisGln: 1.265 ± 0.07
1.459HisArg: 1.459 ± 0.097
1.364HisSer: 1.364 ± 0.086
1.255HisThr: 1.255 ± 0.075
1.518HisVal: 1.518 ± 0.094
0.324HisTrp: 0.324 ± 0.042
0.946HisTyr: 0.946 ± 0.075
0.0HisXaa: 0.0 ± 0.0
Ile
6.646IleAla: 6.646 ± 0.209
1.021IleCys: 1.021 ± 0.067
4.451IleAsp: 4.451 ± 0.137
4.207IleGlu: 4.207 ± 0.152
2.718IlePhe: 2.718 ± 0.145
5.526IleGly: 5.526 ± 0.185
1.628IleHis: 1.628 ± 0.09
5.934IleIle: 5.934 ± 0.196
4.266IleLys: 4.266 ± 0.167
6.606IleLeu: 6.606 ± 0.197
1.728IleMet: 1.728 ± 0.103
4.167IleAsn: 4.167 ± 0.133
2.813IlePro: 2.813 ± 0.124
2.22IleGln: 2.22 ± 0.116
3.888IleArg: 3.888 ± 0.133
4.804IleSer: 4.804 ± 0.146
4.53IleThr: 4.53 ± 0.145
4.874IleVal: 4.874 ± 0.172
0.622IleTrp: 0.622 ± 0.062
2.131IleTyr: 2.131 ± 0.111
0.0IleXaa: 0.0 ± 0.0
Lys
3.948LysAla: 3.948 ± 0.132
0.558LysCys: 0.558 ± 0.059
2.549LysAsp: 2.549 ± 0.116
2.773LysGlu: 2.773 ± 0.113
1.494LysPhe: 1.494 ± 0.095
2.937LysGly: 2.937 ± 0.138
1.354LysHis: 1.354 ± 0.093
3.813LysIle: 3.813 ± 0.137
3.435LysLys: 3.435 ± 0.158
5.606LysLeu: 5.606 ± 0.196
1.608LysMet: 1.608 ± 0.107
2.753LysAsn: 2.753 ± 0.114
1.897LysPro: 1.897 ± 0.098
2.345LysGln: 2.345 ± 0.099
3.36LysArg: 3.36 ± 0.14
2.808LysSer: 2.808 ± 0.125
2.917LysThr: 2.917 ± 0.119
3.863LysVal: 3.863 ± 0.156
0.463LysTrp: 0.463 ± 0.044
1.613LysTyr: 1.613 ± 0.094
0.0LysXaa: 0.0 ± 0.0
Leu
9.384LeuAla: 9.384 ± 0.258
1.424LeuCys: 1.424 ± 0.085
5.207LeuAsp: 5.207 ± 0.161
5.75LeuGlu: 5.75 ± 0.195
3.933LeuPhe: 3.933 ± 0.175
6.905LeuGly: 6.905 ± 0.203
2.838LeuHis: 2.838 ± 0.109
7.229LeuIle: 7.229 ± 0.198
5.242LeuLys: 5.242 ± 0.183
11.41LeuLeu: 11.41 ± 0.355
3.161LeuMet: 3.161 ± 0.138
4.904LeuAsn: 4.904 ± 0.158
5.322LeuPro: 5.322 ± 0.178
4.008LeuGln: 4.008 ± 0.143
6.726LeuArg: 6.726 ± 0.237
7.388LeuSer: 7.388 ± 0.203
6.278LeuThr: 6.278 ± 0.201
7.308LeuVal: 7.308 ± 0.177
1.18LeuTrp: 1.18 ± 0.087
2.902LeuTyr: 2.902 ± 0.121
0.0LeuXaa: 0.0 ± 0.0
Met
2.519MetAla: 2.519 ± 0.116
0.304MetCys: 0.304 ± 0.034
1.165MetAsp: 1.165 ± 0.083
1.135MetGlu: 1.135 ± 0.076
0.946MetPhe: 0.946 ± 0.062
1.708MetGly: 1.708 ± 0.091
0.727MetHis: 0.727 ± 0.058
2.036MetIle: 2.036 ± 0.107
1.444MetLys: 1.444 ± 0.084
3.803MetLeu: 3.803 ± 0.127
0.861MetMet: 0.861 ± 0.072
1.23MetAsn: 1.23 ± 0.071
1.279MetPro: 1.279 ± 0.077
1.235MetGln: 1.235 ± 0.079
1.912MetArg: 1.912 ± 0.099
1.737MetSer: 1.737 ± 0.102
1.668MetThr: 1.668 ± 0.098
2.136MetVal: 2.136 ± 0.107
0.229MetTrp: 0.229 ± 0.034
0.647MetTyr: 0.647 ± 0.055
0.0MetXaa: 0.0 ± 0.0
Asn
3.445AsnAla: 3.445 ± 0.127
0.543AsnCys: 0.543 ± 0.044
2.295AsnAsp: 2.295 ± 0.101
2.146AsnGlu: 2.146 ± 0.104
1.827AsnPhe: 1.827 ± 0.105
2.997AsnGly: 2.997 ± 0.131
1.1AsnHis: 1.1 ± 0.078
3.759AsnIle: 3.759 ± 0.123
2.579AsnLys: 2.579 ± 0.125
4.451AsnLeu: 4.451 ± 0.163
1.409AsnMet: 1.409 ± 0.091
2.499AsnAsn: 2.499 ± 0.131
1.971AsnPro: 1.971 ± 0.097
1.812AsnGln: 1.812 ± 0.093
2.484AsnArg: 2.484 ± 0.113
2.639AsnSer: 2.639 ± 0.127
2.375AsnThr: 2.375 ± 0.117
2.703AsnVal: 2.703 ± 0.12
0.573AsnTrp: 0.573 ± 0.056
1.752AsnTyr: 1.752 ± 0.094
0.0AsnXaa: 0.0 ± 0.0
Pro
3.002ProAla: 3.002 ± 0.139
0.423ProCys: 0.423 ± 0.05
2.136ProAsp: 2.136 ± 0.112
2.464ProGlu: 2.464 ± 0.121
1.503ProPhe: 1.503 ± 0.079
2.594ProGly: 2.594 ± 0.125
0.891ProHis: 0.891 ± 0.07
2.549ProIle: 2.549 ± 0.098
1.713ProLys: 1.713 ± 0.101
4.336ProLeu: 4.336 ± 0.158
1.135ProMet: 1.135 ± 0.064
1.533ProAsn: 1.533 ± 0.08
1.26ProPro: 1.26 ± 0.077
1.688ProGln: 1.688 ± 0.088
1.663ProArg: 1.663 ± 0.104
2.29ProSer: 2.29 ± 0.135
2.061ProThr: 2.061 ± 0.098
3.012ProVal: 3.012 ± 0.127
0.473ProTrp: 0.473 ± 0.06
1.324ProTyr: 1.324 ± 0.085
0.0ProXaa: 0.0 ± 0.0
Gln
3.495GlnAla: 3.495 ± 0.144
0.443GlnCys: 0.443 ± 0.046
1.663GlnAsp: 1.663 ± 0.094
2.116GlnGlu: 2.116 ± 0.126
1.474GlnPhe: 1.474 ± 0.085
2.653GlnGly: 2.653 ± 0.114
1.18GlnHis: 1.18 ± 0.076
2.892GlnIle: 2.892 ± 0.112
2.046GlnLys: 2.046 ± 0.103
5.018GlnLeu: 5.018 ± 0.184
1.115GlnMet: 1.115 ± 0.07
1.419GlnAsn: 1.419 ± 0.077
1.683GlnPro: 1.683 ± 0.09
2.649GlnGln: 2.649 ± 0.135
2.569GlnArg: 2.569 ± 0.126
2.071GlnSer: 2.071 ± 0.098
1.857GlnThr: 1.857 ± 0.098
3.395GlnVal: 3.395 ± 0.144
0.523GlnTrp: 0.523 ± 0.045
1.284GlnTyr: 1.284 ± 0.069
0.0GlnXaa: 0.0 ± 0.0
Arg
4.6ArgAla: 4.6 ± 0.169
0.806ArgCys: 0.806 ± 0.065
3.102ArgAsp: 3.102 ± 0.122
3.4ArgGlu: 3.4 ± 0.141
2.673ArgPhe: 2.673 ± 0.122
3.729ArgGly: 3.729 ± 0.121
1.618ArgHis: 1.618 ± 0.093
4.192ArgIle: 4.192 ± 0.136
2.738ArgLys: 2.738 ± 0.125
6.347ArgLeu: 6.347 ± 0.25
1.802ArgMet: 1.802 ± 0.095
2.514ArgAsn: 2.514 ± 0.113
2.091ArgPro: 2.091 ± 0.102
3.037ArgGln: 3.037 ± 0.133
3.838ArgArg: 3.838 ± 0.16
3.002ArgSer: 3.002 ± 0.111
2.474ArgThr: 2.474 ± 0.127
4.142ArgVal: 4.142 ± 0.142
0.841ArgTrp: 0.841 ± 0.075
2.24ArgTyr: 2.24 ± 0.107
0.0ArgXaa: 0.0 ± 0.0
Ser
4.779SerAla: 4.779 ± 0.152
0.861SerCys: 0.861 ± 0.076
2.997SerAsp: 2.997 ± 0.118
2.773SerGlu: 2.773 ± 0.117
2.245SerPhe: 2.245 ± 0.103
4.55SerGly: 4.55 ± 0.175
1.424SerHis: 1.424 ± 0.097
4.102SerIle: 4.102 ± 0.149
2.892SerLys: 2.892 ± 0.124
6.761SerLeu: 6.761 ± 0.189
1.633SerMet: 1.633 ± 0.089
2.653SerAsn: 2.653 ± 0.118
2.086SerPro: 2.086 ± 0.109
2.434SerGln: 2.434 ± 0.096
3.525SerArg: 3.525 ± 0.129
3.878SerSer: 3.878 ± 0.144
3.296SerThr: 3.296 ± 0.121
3.868SerVal: 3.868 ± 0.123
0.836SerTrp: 0.836 ± 0.065
1.991SerTyr: 1.991 ± 0.1
0.0SerXaa: 0.0 ± 0.0
Thr
4.242ThrAla: 4.242 ± 0.152
0.632ThrCys: 0.632 ± 0.062
2.38ThrAsp: 2.38 ± 0.092
2.723ThrGlu: 2.723 ± 0.118
2.076ThrPhe: 2.076 ± 0.115
4.018ThrGly: 4.018 ± 0.159
1.215ThrHis: 1.215 ± 0.07
3.963ThrIle: 3.963 ± 0.15
2.275ThrLys: 2.275 ± 0.109
6.796ThrLeu: 6.796 ± 0.192
1.255ThrMet: 1.255 ± 0.08
2.3ThrAsn: 2.3 ± 0.104
2.161ThrPro: 2.161 ± 0.096
1.996ThrGln: 1.996 ± 0.095
3.037ThrArg: 3.037 ± 0.117
3.002ThrSer: 3.002 ± 0.12
3.002ThrThr: 3.002 ± 0.152
3.779ThrVal: 3.779 ± 0.151
0.612ThrTrp: 0.612 ± 0.058
1.344ThrTyr: 1.344 ± 0.088
0.0ThrXaa: 0.0 ± 0.0
Val
5.695ValAla: 5.695 ± 0.171
0.856ValCys: 0.856 ± 0.06
3.794ValAsp: 3.794 ± 0.146
3.813ValGlu: 3.813 ± 0.154
2.419ValPhe: 2.419 ± 0.119
4.545ValGly: 4.545 ± 0.156
1.603ValHis: 1.603 ± 0.096
5.551ValIle: 5.551 ± 0.164
3.699ValLys: 3.699 ± 0.131
7.647ValLeu: 7.647 ± 0.202
2.106ValMet: 2.106 ± 0.103
3.36ValAsn: 3.36 ± 0.121
2.683ValPro: 2.683 ± 0.104
2.146ValGln: 2.146 ± 0.112
4.072ValArg: 4.072 ± 0.148
4.56ValSer: 4.56 ± 0.148
4.162ValThr: 4.162 ± 0.148
5.621ValVal: 5.621 ± 0.224
0.622ValTrp: 0.622 ± 0.054
1.668ValTyr: 1.668 ± 0.1
0.0ValXaa: 0.0 ± 0.0
Trp
0.642TrpAla: 0.642 ± 0.062
0.169TrpCys: 0.169 ± 0.03
0.448TrpAsp: 0.448 ± 0.048
0.418TrpGlu: 0.418 ± 0.05
0.518TrpPhe: 0.518 ± 0.05
0.592TrpGly: 0.592 ± 0.053
0.473TrpHis: 0.473 ± 0.049
0.727TrpIle: 0.727 ± 0.068
0.408TrpLys: 0.408 ± 0.05
1.772TrpLeu: 1.772 ± 0.101
0.363TrpMet: 0.363 ± 0.046
0.358TrpAsn: 0.358 ± 0.046
0.453TrpPro: 0.453 ± 0.05
0.861TrpGln: 0.861 ± 0.065
0.916TrpArg: 0.916 ± 0.073
0.548TrpSer: 0.548 ± 0.054
0.363TrpThr: 0.363 ± 0.041
0.732TrpVal: 0.732 ± 0.057
0.154TrpTrp: 0.154 ± 0.033
0.339TrpTyr: 0.339 ± 0.045
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.265TyrAla: 2.265 ± 0.108
0.632TyrCys: 0.632 ± 0.064
1.548TyrAsp: 1.548 ± 0.102
1.26TyrGlu: 1.26 ± 0.071
1.394TyrPhe: 1.394 ± 0.099
2.275TyrGly: 2.275 ± 0.106
1.045TyrHis: 1.045 ± 0.072
1.971TyrIle: 1.971 ± 0.107
1.324TyrLys: 1.324 ± 0.085
3.54TyrLeu: 3.54 ± 0.139
0.727TyrMet: 0.727 ± 0.061
1.434TyrAsn: 1.434 ± 0.079
1.16TyrPro: 1.16 ± 0.081
1.613TyrGln: 1.613 ± 0.089
2.046TyrArg: 2.046 ± 0.099
1.867TyrSer: 1.867 ± 0.104
1.369TyrThr: 1.369 ± 0.081
1.976TyrVal: 1.976 ± 0.099
0.403TyrTrp: 0.403 ± 0.043
1.289TyrTyr: 1.289 ± 0.094
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 712 proteins (200869 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski