Amino acid dipepetide frequency for Actinomyces bowdenii

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	21.118AlaAla: 21.118 ± 0.261	1.241AlaCys: 1.241 ± 0.043	6.965AlaAsp: 6.965 ± 0.105	7.9AlaGlu: 7.9 ± 0.127	3.105AlaPhe: 3.105 ± 0.072	14.133AlaGly: 14.133 ± 0.179	2.775AlaHis: 2.775 ± 0.054	4.701AlaIle: 4.701 ± 0.086	2.032AlaLys: 2.032 ± 0.062	15.766AlaLeu: 15.766 ± 0.204	3.001AlaMet: 3.001 ± 0.067	1.797AlaAsn: 1.797 ± 0.055	8.78AlaPro: 8.78 ± 0.159	5.642AlaGln: 5.642 ± 0.084	11.064AlaArg: 11.064 ± 0.147	7.942AlaSer: 7.942 ± 0.133	6.808AlaThr: 6.808 ± 0.096	11.48AlaVal: 11.48 ± 0.132	2.214AlaTrp: 2.214 ± 0.064	2.292AlaTyr: 2.292 ± 0.057	0.0AlaXaa: 0.0 ± 0.0
Cys	1.13CysAla: 1.13 ± 0.039	0.087CysCys: 0.087 ± 0.008	0.374CysAsp: 0.374 ± 0.021	0.414CysGlu: 0.414 ± 0.022	0.224CysPhe: 0.224 ± 0.017	0.829CysGly: 0.829 ± 0.033	0.178CysHis: 0.178 ± 0.014	0.222CysIle: 0.222 ± 0.019	0.078CysLys: 0.078 ± 0.009	0.906CysLeu: 0.906 ± 0.032	0.116CysMet: 0.116 ± 0.011	0.102CysAsn: 0.102 ± 0.012	0.474CysPro: 0.474 ± 0.028	0.245CysGln: 0.245 ± 0.015	0.558CysArg: 0.558 ± 0.026	0.475CysSer: 0.475 ± 0.025	0.496CysThr: 0.496 ± 0.026	0.556CysVal: 0.556 ± 0.024	0.116CysTrp: 0.116 ± 0.012	0.154CysTyr: 0.154 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	6.835AspAla: 6.835 ± 0.107	0.39AspCys: 0.39 ± 0.023	3.091AspAsp: 3.091 ± 0.074	3.73AspGlu: 3.73 ± 0.074	1.46AspPhe: 1.46 ± 0.044	5.341AspGly: 5.341 ± 0.104	1.309AspHis: 1.309 ± 0.042	1.936AspIle: 1.936 ± 0.051	0.923AspLys: 0.923 ± 0.043	6.236AspLeu: 6.236 ± 0.084	0.88AspMet: 0.88 ± 0.033	0.879AspAsn: 0.879 ± 0.033	4.356AspPro: 4.356 ± 0.071	1.718AspGln: 1.718 ± 0.043	3.783AspArg: 3.783 ± 0.06	2.931AspSer: 2.931 ± 0.065	2.351AspThr: 2.351 ± 0.056	3.938AspVal: 3.938 ± 0.071	0.842AspTrp: 0.842 ± 0.03	1.347AspTyr: 1.347 ± 0.044	0.0AspXaa: 0.0 ± 0.0
Glu	9.174GluAla: 9.174 ± 0.136	0.342GluCys: 0.342 ± 0.02	3.382GluAsp: 3.382 ± 0.072	4.14GluGlu: 4.14 ± 0.078	1.051GluPhe: 1.051 ± 0.041	5.316GluGly: 5.316 ± 0.086	1.469GluHis: 1.469 ± 0.053	2.49GluIle: 2.49 ± 0.056	0.922GluLys: 0.922 ± 0.04	6.174GluLeu: 6.174 ± 0.099	1.078GluMet: 1.078 ± 0.034	0.792GluAsn: 0.792 ± 0.034	3.516GluPro: 3.516 ± 0.082	2.391GluGln: 2.391 ± 0.061	5.433GluArg: 5.433 ± 0.104	2.625GluSer: 2.625 ± 0.055	2.391GluThr: 2.391 ± 0.053	5.076GluVal: 5.076 ± 0.089	0.589GluTrp: 0.589 ± 0.027	0.862GluTyr: 0.862 ± 0.034	0.0GluXaa: 0.0 ± 0.0
Phe	2.782PheAla: 2.782 ± 0.058	0.188PheCys: 0.188 ± 0.015	1.495PheAsp: 1.495 ± 0.045	1.297PheGlu: 1.297 ± 0.043	0.783PhePhe: 0.783 ± 0.037	2.171PheGly: 2.171 ± 0.058	0.548PheHis: 0.548 ± 0.03	1.066PheIle: 1.066 ± 0.038	0.451PheLys: 0.451 ± 0.026	2.447PheLeu: 2.447 ± 0.066	0.456PheMet: 0.456 ± 0.023	0.567PheAsn: 0.567 ± 0.026	1.177PhePro: 1.177 ± 0.037	0.634PheGln: 0.634 ± 0.028	1.302PheArg: 1.302 ± 0.043	1.655PheSer: 1.655 ± 0.046	1.76PheThr: 1.76 ± 0.05	1.716PheVal: 1.716 ± 0.053	0.319PheTrp: 0.319 ± 0.023	0.584PheTyr: 0.584 ± 0.029	0.0PheXaa: 0.0 ± 0.0
Gly	13.756GlyAla: 13.756 ± 0.17	0.734GlyCys: 0.734 ± 0.034	4.142GlyAsp: 4.142 ± 0.074	5.082GlyGlu: 5.082 ± 0.07	2.364GlyPhe: 2.364 ± 0.05	8.921GlyGly: 8.921 ± 0.148	2.018GlyHis: 2.018 ± 0.051	3.944GlyIle: 3.944 ± 0.069	1.754GlyLys: 1.754 ± 0.051	10.147GlyLeu: 10.147 ± 0.136	2.224GlyMet: 2.224 ± 0.054	1.375GlyAsn: 1.375 ± 0.048	5.979GlyPro: 5.979 ± 0.109	3.614GlyGln: 3.614 ± 0.07	8.093GlyArg: 8.093 ± 0.128	5.98GlySer: 5.98 ± 0.103	5.538GlyThr: 5.538 ± 0.099	7.116GlyVal: 7.116 ± 0.1	1.623GlyTrp: 1.623 ± 0.05	2.055GlyTyr: 2.055 ± 0.056	0.0GlyXaa: 0.0 ± 0.0
His	2.436HisAla: 2.436 ± 0.053	0.207HisCys: 0.207 ± 0.015	1.295HisAsp: 1.295 ± 0.041	1.282HisGlu: 1.282 ± 0.037	0.424HisPhe: 0.424 ± 0.022	2.191HisGly: 2.191 ± 0.046	0.598HisHis: 0.598 ± 0.028	0.674HisIle: 0.674 ± 0.028	0.24HisLys: 0.24 ± 0.018	2.381HisLeu: 2.381 ± 0.057	0.419HisMet: 0.419 ± 0.023	0.361HisAsn: 0.361 ± 0.022	1.581HisPro: 1.581 ± 0.05	0.664HisGln: 0.664 ± 0.028	1.91HisArg: 1.91 ± 0.052	1.113HisSer: 1.113 ± 0.034	0.936HisThr: 0.936 ± 0.033	1.453HisVal: 1.453 ± 0.042	0.342HisTrp: 0.342 ± 0.022	0.495HisTyr: 0.495 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	5.406IleAla: 5.406 ± 0.072	0.328IleCys: 0.328 ± 0.018	2.83IleAsp: 2.83 ± 0.068	2.737IleGlu: 2.737 ± 0.06	0.805IlePhe: 0.805 ± 0.032	3.719IleGly: 3.719 ± 0.075	0.806IleHis: 0.806 ± 0.031	2.022IleIle: 2.022 ± 0.055	0.77IleLys: 0.77 ± 0.034	3.981IleLeu: 3.981 ± 0.074	0.727IleMet: 0.727 ± 0.034	0.869IleAsn: 0.869 ± 0.032	2.216IlePro: 2.216 ± 0.052	0.959IleGln: 0.959 ± 0.032	2.212IleArg: 2.212 ± 0.05	2.391IleSer: 2.391 ± 0.056	2.808IleThr: 2.808 ± 0.065	3.236IleVal: 3.236 ± 0.066	0.382IleTrp: 0.382 ± 0.022	0.699IleTyr: 0.699 ± 0.028	0.0IleXaa: 0.0 ± 0.0
Lys	2.178LysAla: 2.178 ± 0.064	0.079LysCys: 0.079 ± 0.011	1.181LysAsp: 1.181 ± 0.04	1.108LysGlu: 1.108 ± 0.045	0.279LysPhe: 0.279 ± 0.022	1.437LysGly: 1.437 ± 0.046	0.346LysHis: 0.346 ± 0.019	0.624LysIle: 0.624 ± 0.029	0.539LysLys: 0.539 ± 0.036	1.034LysLeu: 1.034 ± 0.043	0.283LysMet: 0.283 ± 0.02	0.387LysAsn: 0.387 ± 0.021	0.865LysPro: 0.865 ± 0.035	0.496LysGln: 0.496 ± 0.023	1.339LysArg: 1.339 ± 0.049	0.831LysSer: 0.831 ± 0.037	0.9LysThr: 0.9 ± 0.036	1.295LysVal: 1.295 ± 0.042	0.182LysTrp: 0.182 ± 0.014	0.361LysTyr: 0.361 ± 0.022	0.0LysXaa: 0.0 ± 0.0
Leu	15.495LeuAla: 15.495 ± 0.188	0.798LeuCys: 0.798 ± 0.036	6.118LeuAsp: 6.118 ± 0.1	6.069LeuGlu: 6.069 ± 0.1	2.125LeuPhe: 2.125 ± 0.058	9.945LeuGly: 9.945 ± 0.137	1.982LeuHis: 1.982 ± 0.048	4.363LeuIle: 4.363 ± 0.088	1.52LeuLys: 1.52 ± 0.045	10.968LeuLeu: 10.968 ± 0.167	2.048LeuMet: 2.048 ± 0.051	1.523LeuAsn: 1.523 ± 0.044	6.032LeuPro: 6.032 ± 0.089	2.194LeuGln: 2.194 ± 0.05	8.046LeuArg: 8.046 ± 0.116	6.457LeuSer: 6.457 ± 0.112	6.271LeuThr: 6.271 ± 0.082	8.749LeuVal: 8.749 ± 0.129	1.333LeuTrp: 1.333 ± 0.043	1.606LeuTyr: 1.606 ± 0.045	0.0LeuXaa: 0.0 ± 0.0
Met	2.724MetAla: 2.724 ± 0.058	0.139MetCys: 0.139 ± 0.012	1.006MetAsp: 1.006 ± 0.035	1.012MetGlu: 1.012 ± 0.033	0.373MetPhe: 0.373 ± 0.022	1.774MetGly: 1.774 ± 0.048	0.364MetHis: 0.364 ± 0.021	0.821MetIle: 0.821 ± 0.029	0.312MetLys: 0.312 ± 0.017	1.965MetLeu: 1.965 ± 0.055	0.374MetMet: 0.374 ± 0.021	0.391MetAsn: 0.391 ± 0.022	1.34MetPro: 1.34 ± 0.045	0.382MetGln: 0.382 ± 0.022	1.734MetArg: 1.734 ± 0.047	1.703MetSer: 1.703 ± 0.048	1.59MetThr: 1.59 ± 0.042	1.665MetVal: 1.665 ± 0.05	0.216MetTrp: 0.216 ± 0.016	0.239MetTyr: 0.239 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	1.913AsnAla: 1.913 ± 0.055	0.123AsnCys: 0.123 ± 0.012	0.889AsnAsp: 0.889 ± 0.032	0.775AsnGlu: 0.775 ± 0.031	0.426AsnPhe: 0.426 ± 0.029	1.501AsnGly: 1.501 ± 0.05	0.396AsnHis: 0.396 ± 0.026	0.721AsnIle: 0.721 ± 0.029	0.338AsnLys: 0.338 ± 0.019	1.568AsnLeu: 1.568 ± 0.047	0.264AsnMet: 0.264 ± 0.017	0.374AsnAsn: 0.374 ± 0.023	1.249AsnPro: 1.249 ± 0.042	0.469AsnGln: 0.469 ± 0.023	1.177AsnArg: 1.177 ± 0.037	0.817AsnSer: 0.817 ± 0.032	0.863AsnThr: 0.863 ± 0.037	1.086AsnVal: 1.086 ± 0.033	0.267AsnTrp: 0.267 ± 0.017	0.401AsnTyr: 0.401 ± 0.02	0.0AsnXaa: 0.0 ± 0.0
Pro	9.423ProAla: 9.423 ± 0.154	0.34ProCys: 0.34 ± 0.02	3.61ProAsp: 3.61 ± 0.065	4.243ProGlu: 4.243 ± 0.097	1.351ProPhe: 1.351 ± 0.039	7.31ProGly: 7.31 ± 0.122	1.306ProHis: 1.306 ± 0.043	1.681ProIle: 1.681 ± 0.047	0.698ProLys: 0.698 ± 0.033	5.172ProLeu: 5.172 ± 0.084	1.148ProMet: 1.148 ± 0.036	0.716ProAsn: 0.716 ± 0.032	3.157ProPro: 3.157 ± 0.091	2.512ProGln: 2.512 ± 0.064	4.285ProArg: 4.285 ± 0.089	3.925ProSer: 3.925 ± 0.083	3.36ProThr: 3.36 ± 0.06	4.955ProVal: 4.955 ± 0.079	0.987ProTrp: 0.987 ± 0.035	1.052ProTyr: 1.052 ± 0.036	0.0ProXaa: 0.0 ± 0.0
Gln	5.423GlnAla: 5.423 ± 0.072	0.218GlnCys: 0.218 ± 0.019	2.151GlnAsp: 2.151 ± 0.051	2.487GlnGlu: 2.487 ± 0.053	0.602GlnPhe: 0.602 ± 0.023	3.367GlnGly: 3.367 ± 0.065	0.576GlnHis: 0.576 ± 0.026	1.272GlnIle: 1.272 ± 0.041	0.38GlnLys: 0.38 ± 0.022	2.414GlnLeu: 2.414 ± 0.06	0.669GlnMet: 0.669 ± 0.032	0.367GlnAsn: 0.367 ± 0.024	1.677GlnPro: 1.677 ± 0.049	1.109GlnGln: 1.109 ± 0.04	2.704GlnArg: 2.704 ± 0.062	1.394GlnSer: 1.394 ± 0.046	1.297GlnThr: 1.297 ± 0.042	2.979GlnVal: 2.979 ± 0.059	0.596GlnTrp: 0.596 ± 0.03	0.513GlnTyr: 0.513 ± 0.026	0.0GlnXaa: 0.0 ± 0.0
Arg	10.906ArgAla: 10.906 ± 0.139	0.52ArgCys: 0.52 ± 0.026	3.798ArgAsp: 3.798 ± 0.076	4.56ArgGlu: 4.56 ± 0.082	1.905ArgPhe: 1.905 ± 0.055	6.296ArgGly: 6.296 ± 0.111	1.757ArgHis: 1.757 ± 0.045	3.593ArgIle: 3.593 ± 0.054	1.196ArgLys: 1.196 ± 0.045	8.481ArgLeu: 8.481 ± 0.122	1.784ArgMet: 1.784 ± 0.045	1.087ArgAsn: 1.087 ± 0.042	4.887ArgPro: 4.887 ± 0.082	2.487ArgGln: 2.487 ± 0.058	7.922ArgArg: 7.922 ± 0.138	4.854ArgSer: 4.854 ± 0.077	4.413ArgThr: 4.413 ± 0.064	5.657ArgVal: 5.657 ± 0.085	1.17ArgTrp: 1.17 ± 0.038	1.512ArgTyr: 1.512 ± 0.047	0.0ArgXaa: 0.0 ± 0.0
Ser	8.269SerAla: 8.269 ± 0.12	0.486SerCys: 0.486 ± 0.03	2.561SerAsp: 2.561 ± 0.063	2.62SerGlu: 2.62 ± 0.055	1.697SerPhe: 1.697 ± 0.049	6.331SerGly: 6.331 ± 0.093	1.214SerHis: 1.214 ± 0.04	2.249SerIle: 2.249 ± 0.052	0.878SerLys: 0.878 ± 0.037	5.897SerLeu: 5.897 ± 0.09	1.3SerMet: 1.3 ± 0.043	0.934SerAsn: 0.934 ± 0.033	3.999SerPro: 3.999 ± 0.086	2.209SerGln: 2.209 ± 0.053	4.55SerArg: 4.55 ± 0.087	4.04SerSer: 4.04 ± 0.084	3.918SerThr: 3.918 ± 0.085	4.141SerVal: 4.141 ± 0.079	1.059SerTrp: 1.059 ± 0.036	1.151SerTyr: 1.151 ± 0.039	0.0SerXaa: 0.0 ± 0.0
Thr	7.741ThrAla: 7.741 ± 0.094	0.504ThrCys: 0.504 ± 0.027	2.897ThrAsp: 2.897 ± 0.074	2.545ThrGlu: 2.545 ± 0.059	1.404ThrPhe: 1.404 ± 0.049	6.174ThrGly: 6.174 ± 0.101	1.165ThrHis: 1.165 ± 0.04	2.688ThrIle: 2.688 ± 0.069	0.851ThrLys: 0.851 ± 0.034	5.068ThrLeu: 5.068 ± 0.081	1.066ThrMet: 1.066 ± 0.028	0.972ThrAsn: 0.972 ± 0.039	3.565ThrPro: 3.565 ± 0.071	1.552ThrGln: 1.552 ± 0.041	3.751ThrArg: 3.751 ± 0.069	3.36ThrSer: 3.36 ± 0.061	3.892ThrThr: 3.892 ± 0.089	4.887ThrVal: 4.887 ± 0.09	1.006ThrTrp: 1.006 ± 0.033	1.162ThrTyr: 1.162 ± 0.043	0.0ThrXaa: 0.0 ± 0.0
Val	10.045ValAla: 10.045 ± 0.128	0.692ValCys: 0.692 ± 0.028	4.589ValAsp: 4.589 ± 0.08	5.284ValGlu: 5.284 ± 0.088	2.036ValPhe: 2.036 ± 0.061	6.768ValGly: 6.768 ± 0.099	1.529ValHis: 1.529 ± 0.047	3.585ValIle: 3.585 ± 0.067	1.303ValLys: 1.303 ± 0.04	9.329ValLeu: 9.329 ± 0.145	1.601ValMet: 1.601 ± 0.046	1.414ValAsn: 1.414 ± 0.04	4.62ValPro: 4.62 ± 0.061	1.786ValGln: 1.786 ± 0.046	6.004ValArg: 6.004 ± 0.091	4.859ValSer: 4.859 ± 0.082	4.73ValThr: 4.73 ± 0.081	8.198ValVal: 8.198 ± 0.114	0.97ValTrp: 0.97 ± 0.042	1.336ValTyr: 1.336 ± 0.046	0.0ValXaa: 0.0 ± 0.0
Trp	1.803TrpAla: 1.803 ± 0.051	0.165TrpCys: 0.165 ± 0.015	0.815TrpAsp: 0.815 ± 0.034	0.79TrpGlu: 0.79 ± 0.031	0.432TrpPhe: 0.432 ± 0.023	1.157TrpGly: 1.157 ± 0.038	0.296TrpHis: 0.296 ± 0.019	0.598TrpIle: 0.598 ± 0.025	0.252TrpLys: 0.252 ± 0.021	1.613TrpLeu: 1.613 ± 0.046	0.376TrpMet: 0.376 ± 0.023	0.333TrpAsn: 0.333 ± 0.02	0.743TrpPro: 0.743 ± 0.032	0.551TrpGln: 0.551 ± 0.019	1.318TrpArg: 1.318 ± 0.039	0.994TrpSer: 0.994 ± 0.04	0.832TrpThr: 0.832 ± 0.034	1.091TrpVal: 1.091 ± 0.033	0.381TrpTrp: 0.381 ± 0.021	0.322TrpTyr: 0.322 ± 0.024	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.197TyrAla: 2.197 ± 0.056	0.153TyrCys: 0.153 ± 0.014	1.087TyrAsp: 1.087 ± 0.034	1.138TyrGlu: 1.138 ± 0.035	0.554TyrPhe: 0.554 ± 0.026	1.777TyrGly: 1.777 ± 0.05	0.371TyrHis: 0.371 ± 0.018	0.653TyrIle: 0.653 ± 0.028	0.305TyrLys: 0.305 ± 0.022	2.095TyrLeu: 2.095 ± 0.052	0.308TyrMet: 0.308 ± 0.019	0.375TyrAsn: 0.375 ± 0.023	1.019TyrPro: 1.019 ± 0.044	0.583TyrGln: 0.583 ± 0.026	1.602TyrArg: 1.602 ± 0.051	1.159TyrSer: 1.159 ± 0.037	1.095TyrThr: 1.095 ± 0.042	1.404TyrVal: 1.404 ± 0.048	0.268TyrTrp: 0.268 ± 0.021	0.474TyrTyr: 0.474 ± 0.03	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2433 proteins (860907 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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