Amino acid dipepetide frequency for Podarcis muralis (Wall lizard) (Lacerta muralis)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.399AlaAla: 6.399 ± 0.027	1.365AlaCys: 1.365 ± 0.011	3.064AlaAsp: 3.064 ± 0.013	4.762AlaGlu: 4.762 ± 0.021	2.709AlaPhe: 2.709 ± 0.012	4.203AlaGly: 4.203 ± 0.018	1.413AlaHis: 1.413 ± 0.008	3.04AlaIle: 3.04 ± 0.011	3.819AlaLys: 3.819 ± 0.019	6.695AlaLeu: 6.695 ± 0.021	1.547AlaMet: 1.547 ± 0.009	2.314AlaAsn: 2.314 ± 0.011	3.453AlaPro: 3.453 ± 0.018	2.864AlaGln: 2.864 ± 0.014	3.256AlaArg: 3.256 ± 0.014	5.506AlaSer: 5.506 ± 0.02	3.484AlaThr: 3.484 ± 0.013	4.674AlaVal: 4.674 ± 0.017	0.746AlaTrp: 0.746 ± 0.006	1.586AlaTyr: 1.586 ± 0.009	0.0AlaXaa: 0.0 ± 0.0
Cys	1.238CysAla: 1.238 ± 0.011	0.637CysCys: 0.637 ± 0.007	1.06CysAsp: 1.06 ± 0.012	1.298CysGlu: 1.298 ± 0.015	1.01CysPhe: 1.01 ± 0.007	1.795CysGly: 1.795 ± 0.02	0.65CysHis: 0.65 ± 0.006	1.163CysIle: 1.163 ± 0.01	1.26CysLys: 1.26 ± 0.009	2.368CysLeu: 2.368 ± 0.014	0.511CysMet: 0.511 ± 0.007	0.931CysAsn: 0.931 ± 0.008	1.322CysPro: 1.322 ± 0.013	1.09CysGln: 1.09 ± 0.012	1.265CysArg: 1.265 ± 0.012	2.037CysSer: 2.037 ± 0.014	1.142CysThr: 1.142 ± 0.009	1.35CysVal: 1.35 ± 0.011	0.331CysTrp: 0.331 ± 0.004	0.628CysTyr: 0.628 ± 0.005	0.0CysXaa: 0.0 ± 0.0
Asp	2.919AspAla: 2.919 ± 0.012	1.102AspCys: 1.102 ± 0.01	2.705AspAsp: 2.705 ± 0.015	3.475AspGlu: 3.475 ± 0.017	2.166AspPhe: 2.166 ± 0.011	3.275AspGly: 3.275 ± 0.016	1.185AspHis: 1.185 ± 0.006	2.769AspIle: 2.769 ± 0.015	2.637AspLys: 2.637 ± 0.011	5.053AspLeu: 5.053 ± 0.016	1.146AspMet: 1.146 ± 0.007	1.859AspAsn: 1.859 ± 0.011	2.677AspPro: 2.677 ± 0.014	1.847AspGln: 1.847 ± 0.008	2.406AspArg: 2.406 ± 0.011	3.954AspSer: 3.954 ± 0.015	2.409AspThr: 2.409 ± 0.011	3.069AspVal: 3.069 ± 0.015	0.711AspTrp: 0.711 ± 0.006	1.613AspTyr: 1.613 ± 0.01	0.0AspXaa: 0.0 ± 0.0
Glu	5.024GluAla: 5.024 ± 0.021	1.628GluCys: 1.628 ± 0.023	4.229GluAsp: 4.229 ± 0.016	7.612GluGlu: 7.612 ± 0.042	2.135GluPhe: 2.135 ± 0.011	4.16GluGly: 4.16 ± 0.016	1.469GluHis: 1.469 ± 0.009	3.504GluIle: 3.504 ± 0.013	5.578GluLys: 5.578 ± 0.029	6.307GluLeu: 6.307 ± 0.026	1.809GluMet: 1.809 ± 0.009	3.199GluAsn: 3.199 ± 0.014	2.725GluPro: 2.725 ± 0.015	3.105GluGln: 3.105 ± 0.018	4.113GluArg: 4.113 ± 0.02	4.414GluSer: 4.414 ± 0.017	3.453GluThr: 3.453 ± 0.013	4.192GluVal: 4.192 ± 0.015	0.74GluTrp: 0.74 ± 0.005	1.717GluTyr: 1.717 ± 0.009	0.0GluXaa: 0.0 ± 0.0
Phe	2.266PheAla: 2.266 ± 0.01	1.023PheCys: 1.023 ± 0.007	1.795PheAsp: 1.795 ± 0.011	2.112PheGlu: 2.112 ± 0.01	1.746PhePhe: 1.746 ± 0.011	2.263PheGly: 2.263 ± 0.011	1.133PheHis: 1.133 ± 0.008	2.039PheIle: 2.039 ± 0.011	2.055PheLys: 2.055 ± 0.011	4.33PheLeu: 4.33 ± 0.016	0.831PheMet: 0.831 ± 0.006	1.519PheAsn: 1.519 ± 0.009	2.022PhePro: 2.022 ± 0.01	1.883PheGln: 1.883 ± 0.01	2.038PheArg: 2.038 ± 0.01	3.532PheSer: 3.532 ± 0.016	2.125PheThr: 2.125 ± 0.011	2.25PheVal: 2.25 ± 0.011	0.539PheTrp: 0.539 ± 0.006	1.26PheTyr: 1.26 ± 0.007	0.0PheXaa: 0.0 ± 0.0
Gly	3.84GlyAla: 3.84 ± 0.018	1.28GlyCys: 1.28 ± 0.011	3.024GlyAsp: 3.024 ± 0.015	4.205GlyGlu: 4.205 ± 0.02	2.519GlyPhe: 2.519 ± 0.013	4.704GlyGly: 4.704 ± 0.024	1.576GlyHis: 1.576 ± 0.011	2.975GlyIle: 2.975 ± 0.012	4.244GlyLys: 4.244 ± 0.018	5.299GlyLeu: 5.299 ± 0.019	1.376GlyMet: 1.376 ± 0.009	2.508GlyAsn: 2.508 ± 0.012	2.925GlyPro: 2.925 ± 0.023	2.556GlyGln: 2.556 ± 0.013	3.552GlyArg: 3.552 ± 0.015	5.293GlySer: 5.293 ± 0.019	3.418GlyThr: 3.418 ± 0.015	3.459GlyVal: 3.459 ± 0.015	0.834GlyTrp: 0.834 ± 0.007	1.795GlyTyr: 1.795 ± 0.011	0.0GlyXaa: 0.0 ± 0.0
His	1.377HisAla: 1.377 ± 0.009	0.727HisCys: 0.727 ± 0.008	0.932HisAsp: 0.932 ± 0.007	1.381HisGlu: 1.381 ± 0.009	1.108HisPhe: 1.108 ± 0.007	1.469HisGly: 1.469 ± 0.009	0.908HisHis: 0.908 ± 0.011	1.338HisIle: 1.338 ± 0.009	1.365HisLys: 1.365 ± 0.01	2.883HisLeu: 2.883 ± 0.013	0.564HisMet: 0.564 ± 0.005	0.956HisAsn: 0.956 ± 0.007	1.558HisPro: 1.558 ± 0.011	1.451HisGln: 1.451 ± 0.013	1.511HisArg: 1.511 ± 0.01	2.204HisSer: 2.204 ± 0.011	1.571HisThr: 1.571 ± 0.016	1.405HisVal: 1.405 ± 0.009	0.346HisTrp: 0.346 ± 0.004	0.829HisTyr: 0.829 ± 0.007	0.0HisXaa: 0.0 ± 0.0
Ile	2.937IleAla: 2.937 ± 0.013	1.258IleCys: 1.258 ± 0.011	2.318IleAsp: 2.318 ± 0.012	2.773IleGlu: 2.773 ± 0.012	2.092IlePhe: 2.092 ± 0.011	2.429IleGly: 2.429 ± 0.011	1.527IleHis: 1.527 ± 0.014	2.645IleIle: 2.645 ± 0.013	2.95IleLys: 2.95 ± 0.014	5.014IleLeu: 5.014 ± 0.016	1.11IleMet: 1.11 ± 0.007	2.09IleAsn: 2.09 ± 0.011	2.702IlePro: 2.702 ± 0.013	2.383IleGln: 2.383 ± 0.009	2.533IleArg: 2.533 ± 0.01	3.966IleSer: 3.966 ± 0.014	2.787IleThr: 2.787 ± 0.014	2.838IleVal: 2.838 ± 0.011	0.608IleTrp: 0.608 ± 0.006	1.565IleTyr: 1.565 ± 0.011	0.0IleXaa: 0.0 ± 0.0
Lys	4.21LysAla: 4.21 ± 0.019	1.371LysCys: 1.371 ± 0.011	3.304LysAsp: 3.304 ± 0.013	5.358LysGlu: 5.358 ± 0.023	1.831LysPhe: 1.831 ± 0.01	3.407LysGly: 3.407 ± 0.017	1.49LysHis: 1.49 ± 0.01	3.061LysIle: 3.061 ± 0.013	4.849LysLys: 4.849 ± 0.025	5.625LysLeu: 5.625 ± 0.02	1.622LysMet: 1.622 ± 0.01	2.619LysAsn: 2.619 ± 0.011	3.206LysPro: 3.206 ± 0.018	2.799LysGln: 2.799 ± 0.013	3.487LysArg: 3.487 ± 0.015	4.219LysSer: 4.219 ± 0.021	3.19LysThr: 3.19 ± 0.012	3.753LysVal: 3.753 ± 0.013	0.732LysTrp: 0.732 ± 0.006	1.753LysTyr: 1.753 ± 0.011	0.0LysXaa: 0.0 ± 0.0
Leu	6.522LeuAla: 6.522 ± 0.019	2.172LeuCys: 2.172 ± 0.014	4.879LeuAsp: 4.879 ± 0.018	7.221LeuGlu: 7.221 ± 0.03	3.664LeuPhe: 3.664 ± 0.017	5.418LeuGly: 5.418 ± 0.018	2.772LeuHis: 2.772 ± 0.014	4.277LeuIle: 4.277 ± 0.013	6.206LeuLys: 6.206 ± 0.024	10.554LeuLeu: 10.554 ± 0.036	2.099LeuMet: 2.099 ± 0.01	3.833LeuAsn: 3.833 ± 0.013	5.657LeuPro: 5.657 ± 0.02	5.6LeuGln: 5.6 ± 0.022	5.594LeuArg: 5.594 ± 0.019	7.854LeuSer: 7.854 ± 0.024	5.052LeuThr: 5.052 ± 0.017	5.461LeuVal: 5.461 ± 0.018	1.151LeuTrp: 1.151 ± 0.008	2.689LeuTyr: 2.689 ± 0.012	0.0LeuXaa: 0.0 ± 0.0
Met	1.797MetAla: 1.797 ± 0.009	0.415MetCys: 0.415 ± 0.005	1.356MetAsp: 1.356 ± 0.007	2.053MetGlu: 2.053 ± 0.01	0.833MetPhe: 0.833 ± 0.006	1.331MetGly: 1.331 ± 0.01	0.504MetHis: 0.504 ± 0.005	0.964MetIle: 0.964 ± 0.007	1.572MetLys: 1.572 ± 0.009	2.054MetLeu: 2.054 ± 0.01	0.591MetMet: 0.591 ± 0.005	0.986MetAsn: 0.986 ± 0.008	1.079MetPro: 1.079 ± 0.008	1.011MetGln: 1.011 ± 0.008	1.102MetArg: 1.102 ± 0.007	1.568MetSer: 1.568 ± 0.01	1.114MetThr: 1.114 ± 0.007	1.451MetVal: 1.451 ± 0.008	0.253MetTrp: 0.253 ± 0.003	0.632MetTyr: 0.632 ± 0.005	0.0MetXaa: 0.0 ± 0.0
Asn	2.392AsnAla: 2.392 ± 0.012	0.947AsnCys: 0.947 ± 0.007	1.667AsnAsp: 1.667 ± 0.009	2.44AsnGlu: 2.44 ± 0.012	1.585AsnPhe: 1.585 ± 0.009	2.724AsnGly: 2.724 ± 0.015	0.979AsnHis: 0.979 ± 0.007	2.437AsnIle: 2.437 ± 0.011	2.374AsnLys: 2.374 ± 0.011	4.03AsnLeu: 4.03 ± 0.015	1.028AsnMet: 1.028 ± 0.007	1.796AsnAsn: 1.796 ± 0.011	2.227AsnPro: 2.227 ± 0.011	1.69AsnGln: 1.69 ± 0.008	1.988AsnArg: 1.988 ± 0.009	3.216AsnSer: 3.216 ± 0.014	2.107AsnThr: 2.107 ± 0.012	2.411AsnVal: 2.411 ± 0.012	0.516AsnTrp: 0.516 ± 0.005	1.259AsnTyr: 1.259 ± 0.007	0.0AsnXaa: 0.0 ± 0.0
Pro	3.991ProAla: 3.991 ± 0.019	1.119ProCys: 1.119 ± 0.011	2.637ProAsp: 2.637 ± 0.012	3.858ProGlu: 3.858 ± 0.015	2.03ProPhe: 2.03 ± 0.012	3.896ProGly: 3.896 ± 0.03	1.358ProHis: 1.358 ± 0.009	2.001ProIle: 2.001 ± 0.01	2.758ProLys: 2.758 ± 0.018	4.951ProLeu: 4.951 ± 0.021	0.979ProMet: 0.979 ± 0.007	1.892ProAsn: 1.892 ± 0.01	4.906ProPro: 4.906 ± 0.03	2.456ProGln: 2.456 ± 0.015	2.715ProArg: 2.715 ± 0.013	5.095ProSer: 5.095 ± 0.023	2.757ProThr: 2.757 ± 0.016	3.534ProVal: 3.534 ± 0.015	0.641ProTrp: 0.641 ± 0.006	1.588ProTyr: 1.588 ± 0.014	0.0ProXaa: 0.0 ± 0.0
Gln	3.2GlnAla: 3.2 ± 0.014	1.108GlnCys: 1.108 ± 0.015	2.14GlnAsp: 2.14 ± 0.011	3.703GlnGlu: 3.703 ± 0.019	1.464GlnPhe: 1.464 ± 0.009	2.624GlnGly: 2.624 ± 0.013	1.265GlnHis: 1.265 ± 0.009	2.191GlnIle: 2.191 ± 0.01	2.974GlnLys: 2.974 ± 0.015	4.623GlnLeu: 4.623 ± 0.018	1.103GlnMet: 1.103 ± 0.008	2.005GlnAsn: 2.005 ± 0.011	2.389GlnPro: 2.389 ± 0.017	3.046GlnGln: 3.046 ± 0.028	2.983GlnArg: 2.983 ± 0.015	3.098GlnSer: 3.098 ± 0.014	2.285GlnThr: 2.285 ± 0.011	2.727GlnVal: 2.727 ± 0.012	0.57GlnTrp: 0.57 ± 0.005	1.257GlnTyr: 1.257 ± 0.008	0.0GlnXaa: 0.0 ± 0.0
Arg	3.363ArgAla: 3.363 ± 0.012	1.224ArgCys: 1.224 ± 0.012	2.612ArgAsp: 2.612 ± 0.012	3.815ArgGlu: 3.815 ± 0.019	1.956ArgPhe: 1.956 ± 0.009	3.245ArgGly: 3.245 ± 0.019	1.502ArgHis: 1.502 ± 0.007	2.81ArgIle: 2.81 ± 0.013	3.802ArgLys: 3.802 ± 0.017	5.228ArgLeu: 5.228 ± 0.019	1.233ArgMet: 1.233 ± 0.008	2.289ArgAsn: 2.289 ± 0.009	2.699ArgPro: 2.699 ± 0.012	2.57ArgGln: 2.57 ± 0.012	4.083ArgArg: 4.083 ± 0.021	4.127ArgSer: 4.127 ± 0.018	2.845ArgThr: 2.845 ± 0.013	3.04ArgVal: 3.04 ± 0.014	0.762ArgTrp: 0.762 ± 0.006	1.519ArgTyr: 1.519 ± 0.008	0.0ArgXaa: 0.0 ± 0.0
Ser	5.204SerAla: 5.204 ± 0.018	1.872SerCys: 1.872 ± 0.013	3.778SerAsp: 3.778 ± 0.016	5.006SerGlu: 5.006 ± 0.019	3.427SerPhe: 3.427 ± 0.017	5.089SerGly: 5.089 ± 0.017	2.185SerHis: 2.185 ± 0.013	3.487SerIle: 3.487 ± 0.014	4.272SerLys: 4.272 ± 0.017	8.122SerLeu: 8.122 ± 0.026	1.639SerMet: 1.639 ± 0.009	2.933SerAsn: 2.933 ± 0.015	5.346SerPro: 5.346 ± 0.027	3.609SerGln: 3.609 ± 0.016	4.223SerArg: 4.223 ± 0.017	8.807SerSer: 8.807 ± 0.037	4.317SerThr: 4.317 ± 0.016	4.72SerVal: 4.72 ± 0.016	1.062SerTrp: 1.062 ± 0.008	2.124SerTyr: 2.124 ± 0.011	0.0SerXaa: 0.0 ± 0.0
Thr	3.676ThrAla: 3.676 ± 0.014	1.35ThrCys: 1.35 ± 0.014	2.522ThrAsp: 2.522 ± 0.011	3.567ThrGlu: 3.567 ± 0.014	2.184ThrPhe: 2.184 ± 0.01	3.617ThrGly: 3.617 ± 0.018	1.327ThrHis: 1.327 ± 0.011	2.58ThrIle: 2.58 ± 0.012	2.825ThrLys: 2.825 ± 0.012	5.136ThrLeu: 5.136 ± 0.017	1.121ThrMet: 1.121 ± 0.007	1.833ThrAsn: 1.833 ± 0.01	3.205ThrPro: 3.205 ± 0.019	2.112ThrGln: 2.112 ± 0.01	2.358ThrArg: 2.358 ± 0.01	4.537ThrSer: 4.537 ± 0.017	3.006ThrThr: 3.006 ± 0.031	3.821ThrVal: 3.821 ± 0.017	0.718ThrTrp: 0.718 ± 0.007	1.461ThrTyr: 1.461 ± 0.009	0.0ThrXaa: 0.0 ± 0.0
Val	4.229ValAla: 4.229 ± 0.015	1.499ValCys: 1.499 ± 0.011	2.953ValAsp: 2.953 ± 0.013	3.902ValGlu: 3.902 ± 0.015	2.502ValPhe: 2.502 ± 0.011	3.328ValGly: 3.328 ± 0.014	1.531ValHis: 1.531 ± 0.008	3.045ValIle: 3.045 ± 0.014	3.719ValLys: 3.719 ± 0.014	6.205ValLeu: 6.205 ± 0.02	1.367ValMet: 1.367 ± 0.008	2.387ValAsn: 2.387 ± 0.012	3.314ValPro: 3.314 ± 0.015	2.714ValGln: 2.714 ± 0.013	3.066ValArg: 3.066 ± 0.012	4.698ValSer: 4.698 ± 0.015	3.599ValThr: 3.599 ± 0.016	4.001ValVal: 4.001 ± 0.014	0.765ValTrp: 0.765 ± 0.007	1.678ValTyr: 1.678 ± 0.009	0.0ValXaa: 0.0 ± 0.0
Trp	0.756TrpAla: 0.756 ± 0.006	0.26TrpCys: 0.26 ± 0.004	0.657TrpAsp: 0.657 ± 0.006	0.832TrpGlu: 0.832 ± 0.007	0.46TrpPhe: 0.46 ± 0.005	0.693TrpGly: 0.693 ± 0.007	0.326TrpHis: 0.326 ± 0.004	0.645TrpIle: 0.645 ± 0.006	0.897TrpLys: 0.897 ± 0.008	1.346TrpLeu: 1.346 ± 0.01	0.34TrpMet: 0.34 ± 0.004	0.63TrpAsn: 0.63 ± 0.005	0.501TrpPro: 0.501 ± 0.005	0.613TrpGln: 0.613 ± 0.005	0.796TrpArg: 0.796 ± 0.006	0.892TrpSer: 0.892 ± 0.007	0.7TrpThr: 0.7 ± 0.006	0.721TrpVal: 0.721 ± 0.005	0.233TrpTrp: 0.233 ± 0.003	0.361TrpTyr: 0.361 ± 0.004	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.56TyrAla: 1.56 ± 0.009	0.728TyrCys: 0.728 ± 0.006	1.346TyrAsp: 1.346 ± 0.01	1.74TyrGlu: 1.74 ± 0.009	1.339TyrPhe: 1.339 ± 0.008	1.712TyrGly: 1.712 ± 0.01	0.781TyrHis: 0.781 ± 0.006	1.554TyrIle: 1.554 ± 0.01	1.728TyrLys: 1.728 ± 0.014	2.85TyrLeu: 2.85 ± 0.012	0.651TyrMet: 0.651 ± 0.006	1.233TyrAsn: 1.233 ± 0.006	1.251TyrPro: 1.251 ± 0.008	1.358TyrGln: 1.358 ± 0.011	1.654TyrArg: 1.654 ± 0.009	2.205TyrSer: 2.205 ± 0.011	1.595TyrThr: 1.595 ± 0.009	1.627TyrVal: 1.627 ± 0.009	0.403TyrTrp: 0.403 ± 0.005	1.027TyrTyr: 1.027 ± 0.007	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.003XaaXaa: 0.003 ± 0.002

Statistics based on 36445 proteins (24682227 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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