Amino acid dipepetide frequency for Bacillus virus G

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.814AlaAla: 2.814 ± 0.211
0.366AlaCys: 0.366 ± 0.056
2.587AlaAsp: 2.587 ± 0.172
3.484AlaGlu: 3.484 ± 0.189
2.014AlaPhe: 2.014 ± 0.125
2.821AlaGly: 2.821 ± 0.183
0.814AlaHis: 0.814 ± 0.074
3.608AlaIle: 3.608 ± 0.155
4.222AlaLys: 4.222 ± 0.214
3.663AlaLeu: 3.663 ± 0.195
1.042AlaMet: 1.042 ± 0.091
2.877AlaAsn: 2.877 ± 0.184
1.2AlaPro: 1.2 ± 0.137
1.6AlaGln: 1.6 ± 0.113
1.821AlaArg: 1.821 ± 0.106
3.332AlaSer: 3.332 ± 0.213
2.587AlaThr: 2.587 ± 0.187
2.773AlaVal: 2.773 ± 0.146
0.428AlaTrp: 0.428 ± 0.057
1.89AlaTyr: 1.89 ± 0.092
0.0AlaXaa: 0.0 ± 0.0
Cys
0.241CysAla: 0.241 ± 0.037
0.09CysCys: 0.09 ± 0.023
0.579CysAsp: 0.579 ± 0.071
0.69CysGlu: 0.69 ± 0.068
0.455CysPhe: 0.455 ± 0.062
0.559CysGly: 0.559 ± 0.064
0.172CysHis: 0.172 ± 0.039
0.662CysIle: 0.662 ± 0.073
0.897CysLys: 0.897 ± 0.081
0.669CysLeu: 0.669 ± 0.073
0.159CysMet: 0.159 ± 0.033
0.628CysAsn: 0.628 ± 0.074
0.662CysPro: 0.662 ± 0.069
0.214CysGln: 0.214 ± 0.037
0.276CysArg: 0.276 ± 0.047
0.773CysSer: 0.773 ± 0.086
0.441CysThr: 0.441 ± 0.057
0.531CysVal: 0.531 ± 0.072
0.062CysTrp: 0.062 ± 0.022
0.524CysTyr: 0.524 ± 0.057
0.0CysXaa: 0.0 ± 0.0
Asp
2.614AspAla: 2.614 ± 0.171
0.648AspCys: 0.648 ± 0.079
3.739AspAsp: 3.739 ± 0.2
5.429AspGlu: 5.429 ± 0.226
3.987AspPhe: 3.987 ± 0.179
3.87AspGly: 3.87 ± 0.196
0.766AspHis: 0.766 ± 0.073
5.76AspIle: 5.76 ± 0.224
5.939AspLys: 5.939 ± 0.216
5.663AspLeu: 5.663 ± 0.205
1.573AspMet: 1.573 ± 0.105
3.835AspAsn: 3.835 ± 0.177
1.628AspPro: 1.628 ± 0.112
1.6AspGln: 1.6 ± 0.105
2.104AspArg: 2.104 ± 0.101
4.091AspSer: 4.091 ± 0.175
2.821AspThr: 2.821 ± 0.154
3.787AspVal: 3.787 ± 0.18
0.814AspTrp: 0.814 ± 0.089
2.918AspTyr: 2.918 ± 0.168
0.0AspXaa: 0.0 ± 0.0
Glu
3.822GluAla: 3.822 ± 0.198
0.662GluCys: 0.662 ± 0.069
5.07GluAsp: 5.07 ± 0.21
8.664GluGlu: 8.664 ± 0.364
4.049GluPhe: 4.049 ± 0.217
3.318GluGly: 3.318 ± 0.149
1.269GluHis: 1.269 ± 0.103
7.705GluIle: 7.705 ± 0.248
7.94GluLys: 7.94 ± 0.263
7.974GluLeu: 7.974 ± 0.223
2.366GluMet: 2.366 ± 0.114
5.622GluAsn: 5.622 ± 0.229
1.449GluPro: 1.449 ± 0.109
2.773GluGln: 2.773 ± 0.156
2.946GluArg: 2.946 ± 0.178
4.373GluSer: 4.373 ± 0.19
3.884GluThr: 3.884 ± 0.17
5.429GluVal: 5.429 ± 0.232
0.835GluTrp: 0.835 ± 0.088
3.518GluTyr: 3.518 ± 0.181
0.0GluXaa: 0.0 ± 0.0
Phe
2.007PheAla: 2.007 ± 0.133
0.462PheCys: 0.462 ± 0.056
3.539PheAsp: 3.539 ± 0.159
3.849PheGlu: 3.849 ± 0.194
1.952PhePhe: 1.952 ± 0.122
2.635PheGly: 2.635 ± 0.132
0.8PheHis: 0.8 ± 0.078
3.684PheIle: 3.684 ± 0.199
4.16PheLys: 4.16 ± 0.172
3.297PheLeu: 3.297 ± 0.163
1.007PheMet: 1.007 ± 0.092
3.725PheAsn: 3.725 ± 0.168
1.09PhePro: 1.09 ± 0.096
1.228PheGln: 1.228 ± 0.091
1.531PheArg: 1.531 ± 0.107
3.29PheSer: 3.29 ± 0.16
2.401PheThr: 2.401 ± 0.136
2.835PheVal: 2.835 ± 0.153
0.359PheTrp: 0.359 ± 0.046
2.0PheTyr: 2.0 ± 0.134
0.0PheXaa: 0.0 ± 0.0
Gly
2.532GlyAla: 2.532 ± 0.187
0.531GlyCys: 0.531 ± 0.074
3.277GlyAsp: 3.277 ± 0.184
4.208GlyGlu: 4.208 ± 0.169
2.49GlyPhe: 2.49 ± 0.141
3.387GlyGly: 3.387 ± 0.298
0.848GlyHis: 0.848 ± 0.079
4.367GlyIle: 4.367 ± 0.17
4.898GlyLys: 4.898 ± 0.179
4.008GlyLeu: 4.008 ± 0.178
1.373GlyMet: 1.373 ± 0.115
3.263GlyAsn: 3.263 ± 0.208
0.931GlyPro: 0.931 ± 0.098
1.538GlyGln: 1.538 ± 0.124
1.814GlyArg: 1.814 ± 0.1
3.615GlySer: 3.615 ± 0.247
3.132GlyThr: 3.132 ± 0.204
3.518GlyVal: 3.518 ± 0.182
0.676GlyTrp: 0.676 ± 0.065
2.814GlyTyr: 2.814 ± 0.161
0.0GlyXaa: 0.0 ± 0.0
His
0.752HisAla: 0.752 ± 0.074
0.207HisCys: 0.207 ± 0.042
0.993HisAsp: 0.993 ± 0.075
1.228HisGlu: 1.228 ± 0.087
0.738HisPhe: 0.738 ± 0.075
0.835HisGly: 0.835 ± 0.088
0.379HisHis: 0.379 ± 0.052
1.29HisIle: 1.29 ± 0.096
1.359HisLys: 1.359 ± 0.109
1.559HisLeu: 1.559 ± 0.104
0.435HisMet: 0.435 ± 0.058
1.124HisAsn: 1.124 ± 0.097
0.559HisPro: 0.559 ± 0.066
0.573HisGln: 0.573 ± 0.071
0.607HisArg: 0.607 ± 0.069
1.069HisSer: 1.069 ± 0.083
0.835HisThr: 0.835 ± 0.09
1.09HisVal: 1.09 ± 0.08
0.193HisTrp: 0.193 ± 0.04
0.89HisTyr: 0.89 ± 0.088
0.0HisXaa: 0.0 ± 0.0
Ile
3.891IleAla: 3.891 ± 0.168
1.131IleCys: 1.131 ± 0.09
6.422IleAsp: 6.422 ± 0.227
7.967IleGlu: 7.967 ± 0.286
3.118IlePhe: 3.118 ± 0.16
3.773IleGly: 3.773 ± 0.162
1.255IleHis: 1.255 ± 0.086
6.029IleIle: 6.029 ± 0.262
7.692IleLys: 7.692 ± 0.281
6.105IleLeu: 6.105 ± 0.211
1.697IleMet: 1.697 ± 0.104
5.857IleAsn: 5.857 ± 0.232
2.476IlePro: 2.476 ± 0.163
2.608IleGln: 2.608 ± 0.144
3.221IleArg: 3.221 ± 0.165
6.188IleSer: 6.188 ± 0.247
4.229IleThr: 4.229 ± 0.187
4.946IleVal: 4.946 ± 0.198
0.573IleTrp: 0.573 ± 0.066
3.38IleTyr: 3.38 ± 0.189
0.0IleXaa: 0.0 ± 0.0
Lys
4.208LysAla: 4.208 ± 0.215
0.779LysCys: 0.779 ± 0.071
5.456LysAsp: 5.456 ± 0.214
8.581LysGlu: 8.581 ± 0.36
3.622LysPhe: 3.622 ± 0.151
4.332LysGly: 4.332 ± 0.189
1.587LysHis: 1.587 ± 0.117
7.836LysIle: 7.836 ± 0.303
8.202LysLys: 8.202 ± 0.323
7.898LysLeu: 7.898 ± 0.255
3.146LysMet: 3.146 ± 0.16
6.119LysAsn: 6.119 ± 0.2
2.118LysPro: 2.118 ± 0.137
3.208LysGln: 3.208 ± 0.143
3.553LysArg: 3.553 ± 0.175
5.132LysSer: 5.132 ± 0.208
4.477LysThr: 4.477 ± 0.18
5.85LysVal: 5.85 ± 0.206
0.745LysTrp: 0.745 ± 0.073
4.229LysTyr: 4.229 ± 0.187
0.0LysXaa: 0.0 ± 0.0
Leu
3.994LeuAla: 3.994 ± 0.178
0.579LeuCys: 0.579 ± 0.069
5.698LeuAsp: 5.698 ± 0.223
7.319LeuGlu: 7.319 ± 0.225
3.463LeuPhe: 3.463 ± 0.184
3.559LeuGly: 3.559 ± 0.179
1.428LeuHis: 1.428 ± 0.1
6.54LeuIle: 6.54 ± 0.219
7.422LeuLys: 7.422 ± 0.255
6.367LeuLeu: 6.367 ± 0.23
2.09LeuMet: 2.09 ± 0.125
5.919LeuAsn: 5.919 ± 0.24
2.325LeuPro: 2.325 ± 0.132
2.973LeuGln: 2.973 ± 0.141
3.228LeuArg: 3.228 ± 0.168
6.422LeuSer: 6.422 ± 0.255
4.663LeuThr: 4.663 ± 0.197
4.891LeuVal: 4.891 ± 0.206
0.717LeuTrp: 0.717 ± 0.082
3.456LeuTyr: 3.456 ± 0.171
0.0LeuXaa: 0.0 ± 0.0
Met
1.104MetAla: 1.104 ± 0.088
0.186MetCys: 0.186 ± 0.04
1.338MetAsp: 1.338 ± 0.1
1.766MetGlu: 1.766 ± 0.112
1.18MetPhe: 1.18 ± 0.101
1.283MetGly: 1.283 ± 0.116
0.469MetHis: 0.469 ± 0.06
2.069MetIle: 2.069 ± 0.129
2.877MetLys: 2.877 ± 0.138
2.318MetLeu: 2.318 ± 0.159
0.828MetMet: 0.828 ± 0.103
1.697MetAsn: 1.697 ± 0.118
0.711MetPro: 0.711 ± 0.067
0.738MetGln: 0.738 ± 0.071
1.09MetArg: 1.09 ± 0.093
2.0MetSer: 2.0 ± 0.126
1.373MetThr: 1.373 ± 0.11
1.249MetVal: 1.249 ± 0.098
0.2MetTrp: 0.2 ± 0.041
1.0MetTyr: 1.0 ± 0.071
0.0MetXaa: 0.0 ± 0.0
Asn
3.097AsnAla: 3.097 ± 0.161
0.724AsnCys: 0.724 ± 0.084
3.953AsnAsp: 3.953 ± 0.189
5.422AsnGlu: 5.422 ± 0.212
3.09AsnPhe: 3.09 ± 0.13
4.587AsnGly: 4.587 ± 0.228
1.055AsnHis: 1.055 ± 0.1
5.705AsnIle: 5.705 ± 0.228
6.305AsnLys: 6.305 ± 0.228
5.401AsnLeu: 5.401 ± 0.225
1.614AsnMet: 1.614 ± 0.112
4.967AsnAsn: 4.967 ± 0.221
1.945AsnPro: 1.945 ± 0.12
2.021AsnGln: 2.021 ± 0.124
2.207AsnArg: 2.207 ± 0.112
4.767AsnSer: 4.767 ± 0.205
3.373AsnThr: 3.373 ± 0.166
3.932AsnVal: 3.932 ± 0.148
0.842AsnTrp: 0.842 ± 0.081
3.042AsnTyr: 3.042 ± 0.159
0.0AsnXaa: 0.0 ± 0.0
Pro
1.228ProAla: 1.228 ± 0.091
0.145ProCys: 0.145 ± 0.035
1.593ProAsp: 1.593 ± 0.108
1.973ProGlu: 1.973 ± 0.12
1.318ProPhe: 1.318 ± 0.113
1.4ProGly: 1.4 ± 0.1
0.497ProHis: 0.497 ± 0.052
2.049ProIle: 2.049 ± 0.114
2.311ProLys: 2.311 ± 0.168
1.876ProLeu: 1.876 ± 0.129
0.642ProMet: 0.642 ± 0.065
1.918ProAsn: 1.918 ± 0.115
0.773ProPro: 0.773 ± 0.102
0.793ProGln: 0.793 ± 0.08
0.876ProArg: 0.876 ± 0.082
2.014ProSer: 2.014 ± 0.151
1.807ProThr: 1.807 ± 0.125
1.531ProVal: 1.531 ± 0.109
0.214ProTrp: 0.214 ± 0.039
1.193ProTyr: 1.193 ± 0.093
0.0ProXaa: 0.0 ± 0.0
Gln
1.483GlnAla: 1.483 ± 0.101
0.179GlnCys: 0.179 ± 0.035
1.8GlnAsp: 1.8 ± 0.121
2.587GlnGlu: 2.587 ± 0.146
1.462GlnPhe: 1.462 ± 0.111
1.366GlnGly: 1.366 ± 0.105
0.517GlnHis: 0.517 ± 0.057
2.883GlnIle: 2.883 ± 0.135
2.656GlnLys: 2.656 ± 0.145
3.208GlnLeu: 3.208 ± 0.182
1.049GlnMet: 1.049 ± 0.081
2.028GlnAsn: 2.028 ± 0.107
0.862GlnPro: 0.862 ± 0.09
1.186GlnGln: 1.186 ± 0.094
1.159GlnArg: 1.159 ± 0.093
1.925GlnSer: 1.925 ± 0.116
1.456GlnThr: 1.456 ± 0.112
1.849GlnVal: 1.849 ± 0.121
0.345GlnTrp: 0.345 ± 0.047
1.462GlnTyr: 1.462 ± 0.099
0.0GlnXaa: 0.0 ± 0.0
Arg
1.711ArgAla: 1.711 ± 0.107
0.373ArgCys: 0.373 ± 0.054
2.283ArgAsp: 2.283 ± 0.131
3.097ArgGlu: 3.097 ± 0.166
1.766ArgPhe: 1.766 ± 0.113
2.076ArgGly: 2.076 ± 0.118
0.717ArgHis: 0.717 ± 0.067
3.021ArgIle: 3.021 ± 0.155
3.691ArgLys: 3.691 ± 0.175
3.097ArgLeu: 3.097 ± 0.161
1.042ArgMet: 1.042 ± 0.096
2.249ArgAsn: 2.249 ± 0.129
0.669ArgPro: 0.669 ± 0.082
1.159ArgGln: 1.159 ± 0.101
1.69ArgArg: 1.69 ± 0.117
2.104ArgSer: 2.104 ± 0.131
1.538ArgThr: 1.538 ± 0.089
2.456ArgVal: 2.456 ± 0.142
0.462ArgTrp: 0.462 ± 0.063
1.945ArgTyr: 1.945 ± 0.128
0.0ArgXaa: 0.0 ± 0.0
Ser
2.573SerAla: 2.573 ± 0.183
0.586SerCys: 0.586 ± 0.067
4.16SerAsp: 4.16 ± 0.2
4.567SerGlu: 4.567 ± 0.193
3.449SerPhe: 3.449 ± 0.145
4.111SerGly: 4.111 ± 0.24
1.159SerHis: 1.159 ± 0.091
5.85SerIle: 5.85 ± 0.237
6.091SerLys: 6.091 ± 0.201
6.07SerLeu: 6.07 ± 0.223
1.628SerMet: 1.628 ± 0.111
5.132SerAsn: 5.132 ± 0.21
1.559SerPro: 1.559 ± 0.11
2.442SerGln: 2.442 ± 0.138
2.518SerArg: 2.518 ± 0.133
5.174SerSer: 5.174 ± 0.36
3.615SerThr: 3.615 ± 0.198
3.766SerVal: 3.766 ± 0.181
0.793SerTrp: 0.793 ± 0.078
3.166SerTyr: 3.166 ± 0.164
0.0SerXaa: 0.0 ± 0.0
Thr
2.552ThrAla: 2.552 ± 0.206
0.359ThrCys: 0.359 ± 0.052
2.814ThrAsp: 2.814 ± 0.138
3.373ThrGlu: 3.373 ± 0.177
2.435ThrPhe: 2.435 ± 0.134
2.939ThrGly: 2.939 ± 0.178
0.945ThrHis: 0.945 ± 0.087
5.022ThrIle: 5.022 ± 0.223
4.505ThrLys: 4.505 ± 0.173
4.477ThrLeu: 4.477 ± 0.177
1.193ThrMet: 1.193 ± 0.093
3.277ThrAsn: 3.277 ± 0.151
1.987ThrPro: 1.987 ± 0.129
1.407ThrGln: 1.407 ± 0.113
1.821ThrArg: 1.821 ± 0.104
3.601ThrSer: 3.601 ± 0.211
3.132ThrThr: 3.132 ± 0.223
3.277ThrVal: 3.277 ± 0.182
0.759ThrTrp: 0.759 ± 0.104
2.138ThrTyr: 2.138 ± 0.125
0.0ThrXaa: 0.0 ± 0.0
Val
3.035ValAla: 3.035 ± 0.163
0.635ValCys: 0.635 ± 0.081
4.249ValAsp: 4.249 ± 0.217
5.167ValGlu: 5.167 ± 0.208
2.952ValPhe: 2.952 ± 0.133
3.304ValGly: 3.304 ± 0.144
0.855ValHis: 0.855 ± 0.063
4.574ValIle: 4.574 ± 0.204
5.256ValLys: 5.256 ± 0.199
4.829ValLeu: 4.829 ± 0.205
1.504ValMet: 1.504 ± 0.114
3.877ValAsn: 3.877 ± 0.154
1.89ValPro: 1.89 ± 0.114
1.552ValGln: 1.552 ± 0.098
2.449ValArg: 2.449 ± 0.133
4.498ValSer: 4.498 ± 0.181
3.325ValThr: 3.325 ± 0.166
4.153ValVal: 4.153 ± 0.212
0.51ValTrp: 0.51 ± 0.066
2.587ValTyr: 2.587 ± 0.146
0.0ValXaa: 0.0 ± 0.0
Trp
0.421TrpAla: 0.421 ± 0.055
0.124TrpCys: 0.124 ± 0.026
0.704TrpAsp: 0.704 ± 0.065
0.959TrpGlu: 0.959 ± 0.096
0.414TrpPhe: 0.414 ± 0.056
0.586TrpGly: 0.586 ± 0.071
0.131TrpHis: 0.131 ± 0.027
0.786TrpIle: 0.786 ± 0.062
0.959TrpLys: 0.959 ± 0.077
0.662TrpLeu: 0.662 ± 0.072
0.228TrpMet: 0.228 ± 0.039
0.766TrpAsn: 0.766 ± 0.079
0.138TrpPro: 0.138 ± 0.03
0.386TrpGln: 0.386 ± 0.046
0.373TrpArg: 0.373 ± 0.048
0.738TrpSer: 0.738 ± 0.083
0.573TrpThr: 0.573 ± 0.075
0.662TrpVal: 0.662 ± 0.069
0.097TrpTrp: 0.097 ± 0.026
0.586TrpTyr: 0.586 ± 0.081
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.863TyrAla: 1.863 ± 0.11
0.517TyrCys: 0.517 ± 0.056
3.332TyrAsp: 3.332 ± 0.176
3.339TyrGlu: 3.339 ± 0.167
1.897TyrPhe: 1.897 ± 0.124
2.476TyrGly: 2.476 ± 0.131
1.049TyrHis: 1.049 ± 0.068
3.118TyrIle: 3.118 ± 0.174
3.704TyrLys: 3.704 ± 0.193
3.911TyrLeu: 3.911 ± 0.188
0.855TyrMet: 0.855 ± 0.081
3.173TyrAsn: 3.173 ± 0.18
1.18TyrPro: 1.18 ± 0.084
1.462TyrGln: 1.462 ± 0.114
1.863TyrArg: 1.863 ± 0.116
3.304TyrSer: 3.304 ± 0.185
2.352TyrThr: 2.352 ± 0.144
2.677TyrVal: 2.677 ± 0.165
0.669TyrTrp: 0.669 ± 0.072
2.097TyrTyr: 2.097 ± 0.155
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 675 proteins (144966 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski