Amino acid dipepetide frequency for Dichotomicrobium thermohalophilum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.433AlaAla: 16.433 ± 0.207	1.079AlaCys: 1.079 ± 0.04	6.713AlaAsp: 6.713 ± 0.091	9.091AlaGlu: 9.091 ± 0.13	4.336AlaPhe: 4.336 ± 0.088	10.561AlaGly: 10.561 ± 0.124	2.483AlaHis: 2.483 ± 0.055	5.887AlaIle: 5.887 ± 0.094	3.59AlaLys: 3.59 ± 0.07	13.439AlaLeu: 13.439 ± 0.162	3.327AlaMet: 3.327 ± 0.062	2.637AlaAsn: 2.637 ± 0.055	6.132AlaPro: 6.132 ± 0.105	4.655AlaGln: 4.655 ± 0.095	9.606AlaArg: 9.606 ± 0.111	5.492AlaSer: 5.492 ± 0.079	5.129AlaThr: 5.129 ± 0.076	8.319AlaVal: 8.319 ± 0.123	1.516AlaTrp: 1.516 ± 0.044	2.659AlaTyr: 2.659 ± 0.059	0.0AlaXaa: 0.0 ± 0.0
Cys	0.984CysAla: 0.984 ± 0.034	0.099CysCys: 0.099 ± 0.012	0.563CysAsp: 0.563 ± 0.028	0.519CysGlu: 0.519 ± 0.024	0.331CysPhe: 0.331 ± 0.02	0.946CysGly: 0.946 ± 0.037	0.27CysHis: 0.27 ± 0.019	0.393CysIle: 0.393 ± 0.022	0.189CysLys: 0.189 ± 0.015	0.727CysLeu: 0.727 ± 0.031	0.178CysMet: 0.178 ± 0.014	0.205CysAsn: 0.205 ± 0.015	0.524CysPro: 0.524 ± 0.028	0.251CysGln: 0.251 ± 0.017	0.637CysArg: 0.637 ± 0.03	0.411CysSer: 0.411 ± 0.022	0.436CysThr: 0.436 ± 0.02	0.631CysVal: 0.631 ± 0.027	0.115CysTrp: 0.115 ± 0.011	0.229CysTyr: 0.229 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	6.896AspAla: 6.896 ± 0.101	0.516AspCys: 0.516 ± 0.027	3.326AspAsp: 3.326 ± 0.067	4.174AspGlu: 4.174 ± 0.067	2.245AspPhe: 2.245 ± 0.047	5.052AspGly: 5.052 ± 0.086	1.159AspHis: 1.159 ± 0.037	3.21AspIle: 3.21 ± 0.055	1.822AspLys: 1.822 ± 0.053	5.628AspLeu: 5.628 ± 0.08	1.398AspMet: 1.398 ± 0.043	1.361AspAsn: 1.361 ± 0.047	3.366AspPro: 3.366 ± 0.061	1.793AspGln: 1.793 ± 0.05	4.182AspArg: 4.182 ± 0.069	2.295AspSer: 2.295 ± 0.053	2.846AspThr: 2.846 ± 0.06	4.267AspVal: 4.267 ± 0.081	1.106AspTrp: 1.106 ± 0.038	1.666AspTyr: 1.666 ± 0.043	0.0AspXaa: 0.0 ± 0.0
Glu	8.635GluAla: 8.635 ± 0.114	0.371GluCys: 0.371 ± 0.021	3.701GluAsp: 3.701 ± 0.069	4.44GluGlu: 4.44 ± 0.089	1.827GluPhe: 1.827 ± 0.039	4.932GluGly: 4.932 ± 0.079	1.387GluHis: 1.387 ± 0.04	3.791GluIle: 3.791 ± 0.07	2.484GluLys: 2.484 ± 0.06	5.987GluLeu: 5.987 ± 0.091	1.854GluMet: 1.854 ± 0.043	1.893GluAsn: 1.893 ± 0.052	3.433GluPro: 3.433 ± 0.065	2.723GluGln: 2.723 ± 0.062	5.942GluArg: 5.942 ± 0.099	2.918GluSer: 2.918 ± 0.048	4.432GluThr: 4.432 ± 0.076	4.471GluVal: 4.471 ± 0.085	0.842GluTrp: 0.842 ± 0.031	1.15GluTyr: 1.15 ± 0.037	0.0GluXaa: 0.0 ± 0.0
Phe	4.649PheAla: 4.649 ± 0.08	0.354PheCys: 0.354 ± 0.021	2.558PheAsp: 2.558 ± 0.056	2.259PheGlu: 2.259 ± 0.057	1.425PhePhe: 1.425 ± 0.044	3.51PheGly: 3.51 ± 0.074	0.815PheHis: 0.815 ± 0.028	1.859PheIle: 1.859 ± 0.048	0.874PheLys: 0.874 ± 0.028	3.361PheLeu: 3.361 ± 0.075	0.796PheMet: 0.796 ± 0.034	1.002PheAsn: 1.002 ± 0.039	1.639PhePro: 1.639 ± 0.046	1.047PheGln: 1.047 ± 0.033	2.273PheArg: 2.273 ± 0.054	2.068PheSer: 2.068 ± 0.048	1.898PheThr: 1.898 ± 0.045	2.646PheVal: 2.646 ± 0.058	0.605PheTrp: 0.605 ± 0.03	0.913PheTyr: 0.913 ± 0.032	0.0PheXaa: 0.0 ± 0.0
Gly	9.624GlyAla: 9.624 ± 0.124	0.851GlyCys: 0.851 ± 0.035	4.518GlyAsp: 4.518 ± 0.076	5.745GlyGlu: 5.745 ± 0.084	3.412GlyPhe: 3.412 ± 0.064	7.041GlyGly: 7.041 ± 0.113	1.795GlyHis: 1.795 ± 0.05	4.168GlyIle: 4.168 ± 0.08	2.934GlyLys: 2.934 ± 0.064	8.726GlyLeu: 8.726 ± 0.124	2.205GlyMet: 2.205 ± 0.053	1.976GlyAsn: 1.976 ± 0.052	3.732GlyPro: 3.732 ± 0.064	2.869GlyGln: 2.869 ± 0.061	6.057GlyArg: 6.057 ± 0.089	3.917GlySer: 3.917 ± 0.068	4.217GlyThr: 4.217 ± 0.059	6.416GlyVal: 6.416 ± 0.078	1.363GlyTrp: 1.363 ± 0.041	2.353GlyTyr: 2.353 ± 0.06	0.0GlyXaa: 0.0 ± 0.0
His	2.382HisAla: 2.382 ± 0.055	0.261HisCys: 0.261 ± 0.016	1.266HisAsp: 1.266 ± 0.04	1.259HisGlu: 1.259 ± 0.04	0.848HisPhe: 0.848 ± 0.033	1.909HisGly: 1.909 ± 0.052	0.531HisHis: 0.531 ± 0.025	1.045HisIle: 1.045 ± 0.037	0.533HisLys: 0.533 ± 0.024	1.969HisLeu: 1.969 ± 0.049	0.509HisMet: 0.509 ± 0.024	0.52HisAsn: 0.52 ± 0.024	1.364HisPro: 1.364 ± 0.04	0.601HisGln: 0.601 ± 0.028	1.352HisArg: 1.352 ± 0.047	0.844HisSer: 0.844 ± 0.03	0.914HisThr: 0.914 ± 0.034	1.593HisVal: 1.593 ± 0.045	0.343HisTrp: 0.343 ± 0.02	0.624HisTyr: 0.624 ± 0.027	0.0HisXaa: 0.0 ± 0.0
Ile	7.091IleAla: 7.091 ± 0.101	0.557IleCys: 0.557 ± 0.025	3.39IleAsp: 3.39 ± 0.065	3.634IleGlu: 3.634 ± 0.066	1.79IlePhe: 1.79 ± 0.049	4.857IleGly: 4.857 ± 0.086	0.944IleHis: 0.944 ± 0.028	2.496IleIle: 2.496 ± 0.067	1.426IleLys: 1.426 ± 0.048	4.218IleLeu: 4.218 ± 0.08	1.021IleMet: 1.021 ± 0.037	1.378IleAsn: 1.378 ± 0.044	2.378IlePro: 2.378 ± 0.057	1.224IleGln: 1.224 ± 0.041	3.271IleArg: 3.271 ± 0.061	2.738IleSer: 2.738 ± 0.058	2.752IleThr: 2.752 ± 0.049	3.994IleVal: 3.994 ± 0.071	0.628IleTrp: 0.628 ± 0.026	1.22IleTyr: 1.22 ± 0.036	0.0IleXaa: 0.0 ± 0.0
Lys	3.625LysAla: 3.625 ± 0.066	0.191LysCys: 0.191 ± 0.016	1.594LysAsp: 1.594 ± 0.05	1.72LysGlu: 1.72 ± 0.047	0.855LysPhe: 0.855 ± 0.034	2.271LysGly: 2.271 ± 0.047	0.643LysHis: 0.643 ± 0.031	1.496LysIle: 1.496 ± 0.045	1.159LysLys: 1.159 ± 0.045	3.307LysLeu: 3.307 ± 0.067	0.718LysMet: 0.718 ± 0.03	0.746LysAsn: 0.746 ± 0.033	2.073LysPro: 2.073 ± 0.055	1.101LysGln: 1.101 ± 0.037	2.659LysArg: 2.659 ± 0.055	1.588LysSer: 1.588 ± 0.05	1.672LysThr: 1.672 ± 0.044	2.172LysVal: 2.172 ± 0.047	0.335LysTrp: 0.335 ± 0.018	0.667LysTyr: 0.667 ± 0.031	0.0LysXaa: 0.0 ± 0.0
Leu	12.973LeuAla: 12.973 ± 0.155	0.874LeuCys: 0.874 ± 0.031	5.945LeuAsp: 5.945 ± 0.089	5.98LeuGlu: 5.98 ± 0.082	3.679LeuPhe: 3.679 ± 0.083	7.949LeuGly: 7.949 ± 0.111	1.8LeuHis: 1.8 ± 0.054	5.225LeuIle: 5.225 ± 0.086	3.195LeuLys: 3.195 ± 0.063	9.051LeuLeu: 9.051 ± 0.147	2.41LeuMet: 2.41 ± 0.056	2.591LeuAsn: 2.591 ± 0.056	5.35LeuPro: 5.35 ± 0.09	2.751LeuGln: 2.751 ± 0.055	7.528LeuArg: 7.528 ± 0.102	6.117LeuSer: 6.117 ± 0.091	5.393LeuThr: 5.393 ± 0.082	6.766LeuVal: 6.766 ± 0.101	1.173LeuTrp: 1.173 ± 0.04	2.171LeuTyr: 2.171 ± 0.054	0.0LeuXaa: 0.0 ± 0.0
Met	3.091MetAla: 3.091 ± 0.055	0.182MetCys: 0.182 ± 0.016	1.198MetAsp: 1.198 ± 0.035	1.285MetGlu: 1.285 ± 0.035	0.739MetPhe: 0.739 ± 0.028	1.753MetGly: 1.753 ± 0.046	0.465MetHis: 0.465 ± 0.023	1.287MetIle: 1.287 ± 0.042	0.879MetLys: 0.879 ± 0.032	2.451MetLeu: 2.451 ± 0.058	0.64MetMet: 0.64 ± 0.027	0.685MetAsn: 0.685 ± 0.026	1.497MetPro: 1.497 ± 0.042	0.82MetGln: 0.82 ± 0.029	2.044MetArg: 2.044 ± 0.052	1.771MetSer: 1.771 ± 0.04	1.75MetThr: 1.75 ± 0.05	1.609MetVal: 1.609 ± 0.045	0.217MetTrp: 0.217 ± 0.016	0.319MetTyr: 0.319 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	3.048AsnAla: 3.048 ± 0.064	0.225AsnCys: 0.225 ± 0.019	1.412AsnAsp: 1.412 ± 0.044	1.446AsnGlu: 1.446 ± 0.043	0.927AsnPhe: 0.927 ± 0.031	2.171AsnGly: 2.171 ± 0.059	0.42AsnHis: 0.42 ± 0.022	1.382AsnIle: 1.382 ± 0.043	0.682AsnLys: 0.682 ± 0.027	2.46AsnLeu: 2.46 ± 0.049	0.657AsnMet: 0.657 ± 0.027	0.689AsnAsn: 0.689 ± 0.028	1.781AsnPro: 1.781 ± 0.051	0.729AsnGln: 0.729 ± 0.027	1.7AsnArg: 1.7 ± 0.043	1.017AsnSer: 1.017 ± 0.035	1.271AsnThr: 1.271 ± 0.039	2.034AsnVal: 2.034 ± 0.051	0.409AsnTrp: 0.409 ± 0.025	0.645AsnTyr: 0.645 ± 0.026	0.0AsnXaa: 0.0 ± 0.0
Pro	5.98ProAla: 5.98 ± 0.091	0.374ProCys: 0.374 ± 0.025	4.02ProAsp: 4.02 ± 0.081	4.959ProGlu: 4.959 ± 0.08	1.947ProPhe: 1.947 ± 0.047	4.842ProGly: 4.842 ± 0.082	1.135ProHis: 1.135 ± 0.035	2.309ProIle: 2.309 ± 0.052	1.608ProLys: 1.608 ± 0.045	4.704ProLeu: 4.704 ± 0.074	1.097ProMet: 1.097 ± 0.038	1.257ProAsn: 1.257 ± 0.037	2.842ProPro: 2.842 ± 0.064	1.735ProGln: 1.735 ± 0.046	3.378ProArg: 3.378 ± 0.057	2.658ProSer: 2.658 ± 0.055	2.308ProThr: 2.308 ± 0.048	4.201ProVal: 4.201 ± 0.074	0.686ProTrp: 0.686 ± 0.024	1.232ProTyr: 1.232 ± 0.039	0.0ProXaa: 0.0 ± 0.0
Gln	4.175GlnAla: 4.175 ± 0.082	0.224GlnCys: 0.224 ± 0.015	1.671GlnAsp: 1.671 ± 0.049	1.874GlnGlu: 1.874 ± 0.055	1.08GlnPhe: 1.08 ± 0.036	2.378GlnGly: 2.378 ± 0.052	0.663GlnHis: 0.663 ± 0.03	1.876GlnIle: 1.876 ± 0.051	1.074GlnLys: 1.074 ± 0.044	2.961GlnLeu: 2.961 ± 0.058	0.951GlnMet: 0.951 ± 0.034	0.805GlnAsn: 0.805 ± 0.033	1.972GlnPro: 1.972 ± 0.056	1.395GlnGln: 1.395 ± 0.051	2.813GlnArg: 2.813 ± 0.053	1.767GlnSer: 1.767 ± 0.052	1.93GlnThr: 1.93 ± 0.052	2.305GlnVal: 2.305 ± 0.042	0.387GlnTrp: 0.387 ± 0.023	0.611GlnTyr: 0.611 ± 0.027	0.0GlnXaa: 0.0 ± 0.0
Arg	8.861ArgAla: 8.861 ± 0.119	0.579ArgCys: 0.579 ± 0.028	4.523ArgAsp: 4.523 ± 0.067	5.446ArgGlu: 5.446 ± 0.085	2.957ArgPhe: 2.957 ± 0.062	5.268ArgGly: 5.268 ± 0.082	1.737ArgHis: 1.737 ± 0.044	3.89ArgIle: 3.89 ± 0.067	2.485ArgLys: 2.485 ± 0.061	8.31ArgLeu: 8.31 ± 0.109	1.883ArgMet: 1.883 ± 0.045	1.892ArgAsn: 1.892 ± 0.048	3.632ArgPro: 3.632 ± 0.063	2.67ArgGln: 2.67 ± 0.063	6.073ArgArg: 6.073 ± 0.097	3.228ArgSer: 3.228 ± 0.064	3.339ArgThr: 3.339 ± 0.046	5.209ArgVal: 5.209 ± 0.084	1.0ArgTrp: 1.0 ± 0.034	1.855ArgTyr: 1.855 ± 0.052	0.0ArgXaa: 0.0 ± 0.0
Ser	5.98SerAla: 5.98 ± 0.088	0.392SerCys: 0.392 ± 0.023	2.895SerAsp: 2.895 ± 0.062	3.534SerGlu: 3.534 ± 0.074	1.994SerPhe: 1.994 ± 0.054	5.159SerGly: 5.159 ± 0.083	1.061SerHis: 1.061 ± 0.03	2.24SerIle: 2.24 ± 0.055	1.317SerLys: 1.317 ± 0.04	4.796SerLeu: 4.796 ± 0.078	1.202SerMet: 1.202 ± 0.035	1.191SerAsn: 1.191 ± 0.032	2.569SerPro: 2.569 ± 0.055	1.636SerGln: 1.636 ± 0.049	3.518SerArg: 3.518 ± 0.059	2.382SerSer: 2.382 ± 0.056	2.222SerThr: 2.222 ± 0.051	3.676SerVal: 3.676 ± 0.071	0.709SerTrp: 0.709 ± 0.031	1.285SerTyr: 1.285 ± 0.042	0.0SerXaa: 0.0 ± 0.0
Thr	6.196ThrAla: 6.196 ± 0.09	0.418ThrCys: 0.418 ± 0.025	2.739ThrAsp: 2.739 ± 0.058	2.896ThrGlu: 2.896 ± 0.059	1.862ThrPhe: 1.862 ± 0.042	5.091ThrGly: 5.091 ± 0.08	1.018ThrHis: 1.018 ± 0.032	2.583ThrIle: 2.583 ± 0.054	1.282ThrLys: 1.282 ± 0.043	5.465ThrLeu: 5.465 ± 0.074	1.052ThrMet: 1.052 ± 0.033	1.211ThrAsn: 1.211 ± 0.036	3.312ThrPro: 3.312 ± 0.071	1.539ThrGln: 1.539 ± 0.046	3.412ThrArg: 3.412 ± 0.069	2.532ThrSer: 2.532 ± 0.049	2.532ThrThr: 2.532 ± 0.055	4.156ThrVal: 4.156 ± 0.08	0.607ThrTrp: 0.607 ± 0.028	1.174ThrTyr: 1.174 ± 0.038	0.0ThrXaa: 0.0 ± 0.0
Val	8.511ValAla: 8.511 ± 0.11	0.703ValCys: 0.703 ± 0.03	3.995ValAsp: 3.995 ± 0.062	4.822ValGlu: 4.822 ± 0.08	2.795ValPhe: 2.795 ± 0.057	5.152ValGly: 5.152 ± 0.091	1.464ValHis: 1.464 ± 0.042	4.192ValIle: 4.192 ± 0.072	2.102ValLys: 2.102 ± 0.053	7.259ValLeu: 7.259 ± 0.104	1.981ValMet: 1.981 ± 0.044	2.016ValAsn: 2.016 ± 0.056	3.86ValPro: 3.86 ± 0.069	2.025ValGln: 2.025 ± 0.046	5.069ValArg: 5.069 ± 0.083	4.175ValSer: 4.175 ± 0.07	4.204ValThr: 4.204 ± 0.073	5.567ValVal: 5.567 ± 0.102	0.932ValTrp: 0.932 ± 0.034	1.658ValTyr: 1.658 ± 0.038	0.0ValXaa: 0.0 ± 0.0
Trp	1.376TrpAla: 1.376 ± 0.042	0.111TrpCys: 0.111 ± 0.01	0.685TrpAsp: 0.685 ± 0.03	0.634TrpGlu: 0.634 ± 0.029	0.54TrpPhe: 0.54 ± 0.026	0.958TrpGly: 0.958 ± 0.032	0.333TrpHis: 0.333 ± 0.02	0.625TrpIle: 0.625 ± 0.027	0.326TrpLys: 0.326 ± 0.019	1.787TrpLeu: 1.787 ± 0.049	0.33TrpMet: 0.33 ± 0.02	0.394TrpAsn: 0.394 ± 0.022	0.739TrpPro: 0.739 ± 0.031	0.578TrpGln: 0.578 ± 0.024	1.376TrpArg: 1.376 ± 0.04	0.741TrpSer: 0.741 ± 0.028	0.707TrpThr: 0.707 ± 0.027	0.802TrpVal: 0.802 ± 0.031	0.236TrpTrp: 0.236 ± 0.016	0.306TrpTyr: 0.306 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.575TyrAla: 2.575 ± 0.053	0.279TyrCys: 0.279 ± 0.014	1.597TyrAsp: 1.597 ± 0.042	1.496TyrGlu: 1.496 ± 0.047	0.963TyrPhe: 0.963 ± 0.033	2.116TyrGly: 2.116 ± 0.046	0.544TyrHis: 0.544 ± 0.022	1.051TyrIle: 1.051 ± 0.034	0.632TyrLys: 0.632 ± 0.023	2.314TyrLeu: 2.314 ± 0.052	0.473TyrMet: 0.473 ± 0.024	0.654TyrAsn: 0.654 ± 0.029	1.074TyrPro: 1.074 ± 0.034	0.772TyrGln: 0.772 ± 0.029	1.949TyrArg: 1.949 ± 0.051	1.098TyrSer: 1.098 ± 0.04	1.126TyrThr: 1.126 ± 0.031	1.652TyrVal: 1.652 ± 0.044	0.374TyrTrp: 0.374 ± 0.022	0.658TyrTyr: 0.658 ± 0.034	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2737 proteins (885794 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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