Amino acid dipepetide frequency for Kemerovo virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
10.526AlaAla: 10.526 ± 2.181
1.404AlaCys: 1.404 ± 0.272
5.088AlaAsp: 5.088 ± 0.899
5.614AlaGlu: 5.614 ± 0.958
2.632AlaPhe: 2.632 ± 0.396
6.491AlaGly: 6.491 ± 0.889
3.684AlaHis: 3.684 ± 0.88
5.614AlaIle: 5.614 ± 2.021
2.105AlaLys: 2.105 ± 0.529
12.982AlaLeu: 12.982 ± 1.906
1.404AlaMet: 1.404 ± 0.526
3.509AlaAsn: 3.509 ± 0.544
6.14AlaPro: 6.14 ± 1.255
2.807AlaGln: 2.807 ± 0.573
8.772AlaArg: 8.772 ± 0.938
4.912AlaSer: 4.912 ± 0.848
6.14AlaThr: 6.14 ± 1.135
5.614AlaVal: 5.614 ± 1.27
1.404AlaTrp: 1.404 ± 0.489
2.807AlaTyr: 2.807 ± 0.637
0.0AlaXaa: 0.0 ± 0.0
Cys
1.754CysAla: 1.754 ± 0.591
0.0CysCys: 0.0 ± 0.0
0.526CysAsp: 0.526 ± 0.272
1.053CysGlu: 1.053 ± 0.293
0.351CysPhe: 0.351 ± 0.23
0.702CysGly: 0.702 ± 0.242
0.526CysHis: 0.526 ± 0.332
0.351CysIle: 0.351 ± 0.264
0.0CysLys: 0.0 ± 0.0
1.579CysLeu: 1.579 ± 0.745
0.526CysMet: 0.526 ± 0.244
0.877CysAsn: 0.877 ± 0.29
0.526CysPro: 0.526 ± 0.282
0.526CysGln: 0.526 ± 0.386
1.228CysArg: 1.228 ± 0.393
0.351CysSer: 0.351 ± 0.23
0.702CysThr: 0.702 ± 0.413
1.228CysVal: 1.228 ± 0.703
0.175CysTrp: 0.175 ± 0.185
1.228CysTyr: 1.228 ± 0.496
0.0CysXaa: 0.0 ± 0.0
Asp
5.439AspAla: 5.439 ± 0.774
0.702AspCys: 0.702 ± 0.289
4.561AspAsp: 4.561 ± 0.714
3.509AspGlu: 3.509 ± 0.439
1.93AspPhe: 1.93 ± 0.503
4.035AspGly: 4.035 ± 1.203
1.754AspHis: 1.754 ± 0.558
2.456AspIle: 2.456 ± 0.558
0.877AspLys: 0.877 ± 0.358
5.614AspLeu: 5.614 ± 0.983
1.93AspMet: 1.93 ± 0.446
1.228AspAsn: 1.228 ± 0.363
4.211AspPro: 4.211 ± 0.709
1.93AspGln: 1.93 ± 0.613
5.088AspArg: 5.088 ± 1.408
2.807AspSer: 2.807 ± 0.735
2.807AspThr: 2.807 ± 0.77
5.965AspVal: 5.965 ± 1.308
0.702AspTrp: 0.702 ± 0.555
1.579AspTyr: 1.579 ± 0.648
0.0AspXaa: 0.0 ± 0.0
Glu
6.667GluAla: 6.667 ± 1.386
0.526GluCys: 0.526 ± 0.242
4.386GluAsp: 4.386 ± 0.783
4.035GluGlu: 4.035 ± 0.811
2.456GluPhe: 2.456 ± 0.919
3.333GluGly: 3.333 ± 0.635
1.228GluHis: 1.228 ± 0.532
4.737GluIle: 4.737 ± 0.993
2.456GluLys: 2.456 ± 0.677
3.509GluLeu: 3.509 ± 0.662
1.754GluMet: 1.754 ± 0.703
1.93GluAsn: 1.93 ± 0.582
1.754GluPro: 1.754 ± 0.771
2.456GluGln: 2.456 ± 0.473
5.789GluArg: 5.789 ± 0.928
4.211GluSer: 4.211 ± 1.034
3.158GluThr: 3.158 ± 1.087
5.088GluVal: 5.088 ± 0.731
0.702GluTrp: 0.702 ± 0.373
1.93GluTyr: 1.93 ± 0.669
0.0GluXaa: 0.0 ± 0.0
Phe
3.158PheAla: 3.158 ± 0.503
0.175PheCys: 0.175 ± 0.135
2.281PheAsp: 2.281 ± 0.521
1.93PheGlu: 1.93 ± 0.562
1.93PhePhe: 1.93 ± 0.532
1.579PheGly: 1.579 ± 0.521
2.105PheHis: 2.105 ± 0.623
1.228PheIle: 1.228 ± 0.362
1.228PheLys: 1.228 ± 0.366
3.158PheLeu: 3.158 ± 0.468
0.526PheMet: 0.526 ± 0.331
0.877PheAsn: 0.877 ± 0.279
1.93PhePro: 1.93 ± 0.419
1.053PheGln: 1.053 ± 0.629
4.035PheArg: 4.035 ± 0.757
1.93PheSer: 1.93 ± 0.756
2.281PheThr: 2.281 ± 0.559
2.807PheVal: 2.807 ± 0.694
0.175PheTrp: 0.175 ± 0.201
0.526PheTyr: 0.526 ± 0.374
0.0PheXaa: 0.0 ± 0.0
Gly
5.263GlyAla: 5.263 ± 1.392
0.702GlyCys: 0.702 ± 0.513
4.561GlyAsp: 4.561 ± 0.971
2.807GlyGlu: 2.807 ± 0.636
1.579GlyPhe: 1.579 ± 0.442
2.632GlyGly: 2.632 ± 0.913
2.105GlyHis: 2.105 ± 0.481
3.509GlyIle: 3.509 ± 0.418
1.579GlyLys: 1.579 ± 0.421
2.982GlyLeu: 2.982 ± 0.788
1.579GlyMet: 1.579 ± 0.492
1.053GlyAsn: 1.053 ± 0.594
4.035GlyPro: 4.035 ± 0.951
2.105GlyGln: 2.105 ± 0.795
5.263GlyArg: 5.263 ± 0.973
4.737GlySer: 4.737 ± 0.89
3.684GlyThr: 3.684 ± 0.787
4.211GlyVal: 4.211 ± 0.896
0.877GlyTrp: 0.877 ± 0.377
2.105GlyTyr: 2.105 ± 0.702
0.0GlyXaa: 0.0 ± 0.0
His
3.684HisAla: 3.684 ± 0.727
0.526HisCys: 0.526 ± 0.555
1.228HisAsp: 1.228 ± 0.377
1.228HisGlu: 1.228 ± 0.266
0.702HisPhe: 0.702 ± 0.35
3.158HisGly: 3.158 ± 0.835
1.579HisHis: 1.579 ± 0.496
1.404HisIle: 1.404 ± 0.462
1.053HisLys: 1.053 ± 0.47
2.807HisLeu: 2.807 ± 0.646
0.526HisMet: 0.526 ± 0.247
0.877HisAsn: 0.877 ± 0.361
1.754HisPro: 1.754 ± 0.471
1.754HisGln: 1.754 ± 0.375
3.158HisArg: 3.158 ± 0.739
1.754HisSer: 1.754 ± 0.351
1.93HisThr: 1.93 ± 0.545
2.281HisVal: 2.281 ± 0.634
0.702HisTrp: 0.702 ± 0.456
0.877HisTyr: 0.877 ± 0.384
0.0HisXaa: 0.0 ± 0.0
Ile
3.158IleAla: 3.158 ± 0.77
0.526IleCys: 0.526 ± 0.368
3.509IleAsp: 3.509 ± 0.775
3.509IleGlu: 3.509 ± 1.153
1.579IlePhe: 1.579 ± 0.445
3.333IleGly: 3.333 ± 0.808
1.754IleHis: 1.754 ± 0.804
2.982IleIle: 2.982 ± 0.929
1.754IleLys: 1.754 ± 0.522
4.737IleLeu: 4.737 ± 0.836
1.579IleMet: 1.579 ± 0.474
1.404IleAsn: 1.404 ± 0.426
3.158IlePro: 3.158 ± 0.589
2.105IleGln: 2.105 ± 0.531
4.561IleArg: 4.561 ± 0.657
2.807IleSer: 2.807 ± 0.586
3.684IleThr: 3.684 ± 0.766
1.93IleVal: 1.93 ± 0.719
0.526IleTrp: 0.526 ± 0.302
1.579IleTyr: 1.579 ± 0.464
0.0IleXaa: 0.0 ± 0.0
Lys
2.281LysAla: 2.281 ± 0.986
0.526LysCys: 0.526 ± 0.287
1.93LysAsp: 1.93 ± 0.562
3.509LysGlu: 3.509 ± 1.35
1.404LysPhe: 1.404 ± 0.315
0.877LysGly: 0.877 ± 0.598
0.877LysHis: 0.877 ± 0.464
1.228LysIle: 1.228 ± 0.503
1.579LysLys: 1.579 ± 0.507
1.93LysLeu: 1.93 ± 0.684
0.526LysMet: 0.526 ± 0.251
1.053LysAsn: 1.053 ± 0.397
1.053LysPro: 1.053 ± 0.428
1.404LysGln: 1.404 ± 0.534
2.456LysArg: 2.456 ± 0.837
0.877LysSer: 0.877 ± 0.379
1.404LysThr: 1.404 ± 0.455
1.93LysVal: 1.93 ± 0.596
0.526LysTrp: 0.526 ± 0.301
1.053LysTyr: 1.053 ± 0.358
0.0LysXaa: 0.0 ± 0.0
Leu
10.877LeuAla: 10.877 ± 2.001
1.93LeuCys: 1.93 ± 0.713
4.561LeuAsp: 4.561 ± 1.385
3.86LeuGlu: 3.86 ± 0.68
3.158LeuPhe: 3.158 ± 0.487
5.614LeuGly: 5.614 ± 1.156
2.807LeuHis: 2.807 ± 0.703
2.632LeuIle: 2.632 ± 1.123
2.807LeuLys: 2.807 ± 1.352
11.053LeuLeu: 11.053 ± 1.41
2.105LeuMet: 2.105 ± 0.513
3.86LeuAsn: 3.86 ± 0.542
3.333LeuPro: 3.333 ± 0.703
4.211LeuGln: 4.211 ± 1.146
12.281LeuArg: 12.281 ± 1.886
4.912LeuSer: 4.912 ± 0.748
4.561LeuThr: 4.561 ± 0.567
4.211LeuVal: 4.211 ± 0.575
0.702LeuTrp: 0.702 ± 0.526
2.281LeuTyr: 2.281 ± 0.642
0.0LeuXaa: 0.0 ± 0.0
Met
2.982MetAla: 2.982 ± 0.669
0.526MetCys: 0.526 ± 0.35
1.754MetAsp: 1.754 ± 0.396
1.579MetGlu: 1.579 ± 0.355
0.702MetPhe: 0.702 ± 0.203
0.526MetGly: 0.526 ± 0.322
1.053MetHis: 1.053 ± 0.415
1.228MetIle: 1.228 ± 0.429
0.526MetLys: 0.526 ± 0.35
3.158MetLeu: 3.158 ± 0.607
1.228MetMet: 1.228 ± 0.569
0.877MetAsn: 0.877 ± 0.354
0.351MetPro: 0.351 ± 0.401
0.877MetGln: 0.877 ± 0.388
2.281MetArg: 2.281 ± 0.599
2.281MetSer: 2.281 ± 0.497
0.877MetThr: 0.877 ± 0.296
1.228MetVal: 1.228 ± 0.503
0.175MetTrp: 0.175 ± 0.187
1.404MetTyr: 1.404 ± 0.452
0.0MetXaa: 0.0 ± 0.0
Asn
4.561AsnAla: 4.561 ± 0.953
0.175AsnCys: 0.175 ± 0.187
0.877AsnAsp: 0.877 ± 0.425
2.632AsnGlu: 2.632 ± 0.933
0.526AsnPhe: 0.526 ± 0.266
2.105AsnGly: 2.105 ± 0.464
0.526AsnHis: 0.526 ± 0.266
1.228AsnIle: 1.228 ± 0.516
0.526AsnLys: 0.526 ± 0.304
1.754AsnLeu: 1.754 ± 0.648
0.877AsnMet: 0.877 ± 0.45
0.877AsnAsn: 0.877 ± 0.458
1.579AsnPro: 1.579 ± 0.465
0.702AsnGln: 0.702 ± 0.542
1.053AsnArg: 1.053 ± 0.347
1.93AsnSer: 1.93 ± 0.488
1.228AsnThr: 1.228 ± 0.653
3.333AsnVal: 3.333 ± 0.454
0.351AsnTrp: 0.351 ± 0.16
0.877AsnTyr: 0.877 ± 0.306
0.0AsnXaa: 0.0 ± 0.0
Pro
3.86ProAla: 3.86 ± 0.585
0.0ProCys: 0.0 ± 0.0
3.509ProAsp: 3.509 ± 0.442
4.737ProGlu: 4.737 ± 0.622
1.93ProPhe: 1.93 ± 0.324
3.158ProGly: 3.158 ± 0.773
1.93ProHis: 1.93 ± 1.028
2.456ProIle: 2.456 ± 0.683
0.702ProLys: 0.702 ± 0.41
4.386ProLeu: 4.386 ± 0.731
1.93ProMet: 1.93 ± 0.581
1.053ProAsn: 1.053 ± 0.386
4.035ProPro: 4.035 ± 1.085
1.404ProGln: 1.404 ± 0.414
4.386ProArg: 4.386 ± 0.609
2.982ProSer: 2.982 ± 0.588
3.86ProThr: 3.86 ± 0.85
3.509ProVal: 3.509 ± 1.046
0.877ProTrp: 0.877 ± 0.42
2.281ProTyr: 2.281 ± 0.477
0.0ProXaa: 0.0 ± 0.0
Gln
2.982GlnAla: 2.982 ± 0.898
1.053GlnCys: 1.053 ± 0.38
1.579GlnAsp: 1.579 ± 0.412
1.754GlnGlu: 1.754 ± 0.602
0.526GlnPhe: 0.526 ± 0.182
2.105GlnGly: 2.105 ± 0.615
0.702GlnHis: 0.702 ± 0.26
2.632GlnIle: 2.632 ± 0.535
1.053GlnLys: 1.053 ± 0.398
3.158GlnLeu: 3.158 ± 0.723
0.877GlnMet: 0.877 ± 0.397
1.404GlnAsn: 1.404 ± 0.685
1.228GlnPro: 1.228 ± 0.475
1.404GlnGln: 1.404 ± 0.6
4.737GlnArg: 4.737 ± 1.292
1.754GlnSer: 1.754 ± 0.637
3.86GlnThr: 3.86 ± 0.596
1.404GlnVal: 1.404 ± 0.361
0.175GlnTrp: 0.175 ± 0.135
0.702GlnTyr: 0.702 ± 0.573
0.0GlnXaa: 0.0 ± 0.0
Arg
8.421ArgAla: 8.421 ± 1.067
1.404ArgCys: 1.404 ± 0.467
5.789ArgAsp: 5.789 ± 0.903
7.368ArgGlu: 7.368 ± 1.241
5.263ArgPhe: 5.263 ± 0.838
3.86ArgGly: 3.86 ± 0.793
2.456ArgHis: 2.456 ± 0.733
5.263ArgIle: 5.263 ± 0.954
2.807ArgLys: 2.807 ± 0.59
7.544ArgLeu: 7.544 ± 1.159
2.982ArgMet: 2.982 ± 0.554
2.982ArgAsn: 2.982 ± 0.451
4.737ArgPro: 4.737 ± 0.965
3.158ArgGln: 3.158 ± 0.456
9.298ArgArg: 9.298 ± 1.657
5.789ArgSer: 5.789 ± 0.678
7.368ArgThr: 7.368 ± 1.306
6.316ArgVal: 6.316 ± 1.203
0.702ArgTrp: 0.702 ± 0.265
2.281ArgTyr: 2.281 ± 0.722
0.0ArgXaa: 0.0 ± 0.0
Ser
5.965SerAla: 5.965 ± 0.77
0.351SerCys: 0.351 ± 0.37
3.86SerAsp: 3.86 ± 0.718
4.211SerGlu: 4.211 ± 0.652
2.456SerPhe: 2.456 ± 0.912
4.386SerGly: 4.386 ± 0.844
2.105SerHis: 2.105 ± 0.437
2.632SerIle: 2.632 ± 0.693
1.93SerLys: 1.93 ± 0.749
5.088SerLeu: 5.088 ± 0.965
1.228SerMet: 1.228 ± 0.511
1.404SerAsn: 1.404 ± 0.462
2.632SerPro: 2.632 ± 0.388
1.754SerGln: 1.754 ± 0.709
5.965SerArg: 5.965 ± 0.828
4.737SerSer: 4.737 ± 1.083
3.86SerThr: 3.86 ± 0.866
4.035SerVal: 4.035 ± 0.652
0.702SerTrp: 0.702 ± 0.321
1.93SerTyr: 1.93 ± 0.426
0.0SerXaa: 0.0 ± 0.0
Thr
6.667ThrAla: 6.667 ± 1.4
1.404ThrCys: 1.404 ± 0.657
2.281ThrAsp: 2.281 ± 0.676
3.333ThrGlu: 3.333 ± 0.748
2.456ThrPhe: 2.456 ± 0.661
2.632ThrGly: 2.632 ± 0.589
2.982ThrHis: 2.982 ± 0.663
2.982ThrIle: 2.982 ± 0.417
1.228ThrLys: 1.228 ± 0.463
7.018ThrLeu: 7.018 ± 1.262
1.579ThrMet: 1.579 ± 0.655
0.702ThrAsn: 0.702 ± 0.292
4.912ThrPro: 4.912 ± 1.051
2.105ThrGln: 2.105 ± 0.684
4.386ThrArg: 4.386 ± 0.668
5.965ThrSer: 5.965 ± 1.449
3.86ThrThr: 3.86 ± 1.011
3.158ThrVal: 3.158 ± 0.541
0.351ThrTrp: 0.351 ± 0.243
1.579ThrTyr: 1.579 ± 0.545
0.0ThrXaa: 0.0 ± 0.0
Val
6.842ValAla: 6.842 ± 1.044
1.579ValCys: 1.579 ± 0.37
4.737ValAsp: 4.737 ± 0.817
3.158ValGlu: 3.158 ± 0.62
1.93ValPhe: 1.93 ± 0.563
3.509ValGly: 3.509 ± 0.759
1.93ValHis: 1.93 ± 0.424
3.509ValIle: 3.509 ± 0.519
2.456ValLys: 2.456 ± 0.53
5.789ValLeu: 5.789 ± 0.647
1.404ValMet: 1.404 ± 0.488
1.228ValAsn: 1.228 ± 0.408
3.86ValPro: 3.86 ± 0.967
2.281ValGln: 2.281 ± 0.488
7.719ValArg: 7.719 ± 1.992
4.035ValSer: 4.035 ± 0.866
2.807ValThr: 2.807 ± 0.524
5.263ValVal: 5.263 ± 0.602
0.526ValTrp: 0.526 ± 0.209
3.158ValTyr: 3.158 ± 0.741
0.0ValXaa: 0.0 ± 0.0
Trp
0.526TrpAla: 0.526 ± 0.28
0.526TrpCys: 0.526 ± 0.415
0.702TrpAsp: 0.702 ± 0.267
0.526TrpGlu: 0.526 ± 0.306
0.526TrpPhe: 0.526 ± 0.221
0.351TrpGly: 0.351 ± 0.16
0.175TrpHis: 0.175 ± 0.176
0.877TrpIle: 0.877 ± 0.352
0.702TrpLys: 0.702 ± 0.406
1.053TrpLeu: 1.053 ± 0.555
0.351TrpMet: 0.351 ± 0.37
0.526TrpAsn: 0.526 ± 0.272
0.175TrpPro: 0.175 ± 0.24
0.175TrpGln: 0.175 ± 0.201
1.053TrpArg: 1.053 ± 0.376
0.526TrpSer: 0.526 ± 0.247
0.877TrpThr: 0.877 ± 0.362
0.702TrpVal: 0.702 ± 0.366
0.0TrpTrp: 0.0 ± 0.0
0.175TrpTyr: 0.175 ± 0.139
0.0TrpXaa: 0.0 ± 0.0
Tyr
4.035TyrAla: 4.035 ± 0.896
0.175TyrCys: 0.175 ± 0.201
1.404TyrAsp: 1.404 ± 0.242
1.754TyrGlu: 1.754 ± 0.504
0.877TyrPhe: 0.877 ± 0.358
2.982TyrGly: 2.982 ± 0.618
0.702TyrHis: 0.702 ± 0.248
1.228TyrIle: 1.228 ± 0.533
1.053TyrLys: 1.053 ± 0.392
2.456TyrLeu: 2.456 ± 0.809
0.526TyrMet: 0.526 ± 0.267
0.175TyrAsn: 0.175 ± 0.135
1.579TyrPro: 1.579 ± 0.638
0.877TyrGln: 0.877 ± 0.235
2.281TyrArg: 2.281 ± 0.771
1.93TyrSer: 1.93 ± 0.997
2.632TyrThr: 2.632 ± 0.881
3.509TyrVal: 3.509 ± 0.758
0.175TyrTrp: 0.175 ± 0.201
0.702TyrTyr: 0.702 ± 0.394
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 10 proteins (5701 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski