Amino acid dipepetide frequency for Marichromatium purpuratum 984

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.658AlaAla: 16.658 ± 0.197	1.246AlaCys: 1.246 ± 0.038	6.44AlaAsp: 6.44 ± 0.092	9.329AlaGlu: 9.329 ± 0.116	3.523AlaPhe: 3.523 ± 0.061	9.844AlaGly: 9.844 ± 0.13	2.742AlaHis: 2.742 ± 0.059	5.434AlaIle: 5.434 ± 0.082	2.127AlaLys: 2.127 ± 0.045	17.487AlaLeu: 17.487 ± 0.186	2.761AlaMet: 2.761 ± 0.056	2.378AlaAsn: 2.378 ± 0.053	6.539AlaPro: 6.539 ± 0.108	3.998AlaGln: 3.998 ± 0.069	12.028AlaArg: 12.028 ± 0.143	5.242AlaSer: 5.242 ± 0.074	5.882AlaThr: 5.882 ± 0.098	8.385AlaVal: 8.385 ± 0.092	1.553AlaTrp: 1.553 ± 0.041	2.19AlaTyr: 2.19 ± 0.05	0.0AlaXaa: 0.0 ± 0.0
Cys	1.389CysAla: 1.389 ± 0.039	0.189CysCys: 0.189 ± 0.015	0.607CysAsp: 0.607 ± 0.023	0.642CysGlu: 0.642 ± 0.026	0.309CysPhe: 0.309 ± 0.018	1.057CysGly: 1.057 ± 0.033	0.353CysHis: 0.353 ± 0.024	0.379CysIle: 0.379 ± 0.021	0.172CysLys: 0.172 ± 0.013	0.912CysLeu: 0.912 ± 0.03	0.185CysMet: 0.185 ± 0.012	0.236CysAsn: 0.236 ± 0.016	0.613CysPro: 0.613 ± 0.022	0.271CysGln: 0.271 ± 0.017	0.829CysArg: 0.829 ± 0.027	0.494CysSer: 0.494 ± 0.02	0.469CysThr: 0.469 ± 0.023	0.716CysVal: 0.716 ± 0.03	0.147CysTrp: 0.147 ± 0.011	0.265CysTyr: 0.265 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	6.896AspAla: 6.896 ± 0.089	0.629AspCys: 0.629 ± 0.027	3.513AspAsp: 3.513 ± 0.071	3.684AspGlu: 3.684 ± 0.058	2.014AspPhe: 2.014 ± 0.04	5.13AspGly: 5.13 ± 0.08	1.415AspHis: 1.415 ± 0.042	2.332AspIle: 2.332 ± 0.054	1.131AspLys: 1.131 ± 0.04	6.303AspLeu: 6.303 ± 0.093	1.142AspMet: 1.142 ± 0.036	1.216AspAsn: 1.216 ± 0.036	4.267AspPro: 4.267 ± 0.068	2.23AspGln: 2.23 ± 0.045	4.445AspArg: 4.445 ± 0.067	2.391AspSer: 2.391 ± 0.058	2.888AspThr: 2.888 ± 0.05	3.111AspVal: 3.111 ± 0.063	1.274AspTrp: 1.274 ± 0.037	1.78AspTyr: 1.78 ± 0.038	0.0AspXaa: 0.0 ± 0.0
Glu	8.282GluAla: 8.282 ± 0.125	0.496GluCys: 0.496 ± 0.021	3.027GluAsp: 3.027 ± 0.054	3.18GluGlu: 3.18 ± 0.075	1.671GluPhe: 1.671 ± 0.041	4.563GluGly: 4.563 ± 0.066	1.977GluHis: 1.977 ± 0.047	3.455GluIle: 3.455 ± 0.065	1.004GluLys: 1.004 ± 0.037	7.399GluLeu: 7.399 ± 0.098	1.291GluMet: 1.291 ± 0.036	1.001GluAsn: 1.001 ± 0.027	3.378GluPro: 3.378 ± 0.063	3.788GluGln: 3.788 ± 0.064	8.035GluArg: 8.035 ± 0.106	2.984GluSer: 2.984 ± 0.056	3.963GluThr: 3.963 ± 0.061	4.873GluVal: 4.873 ± 0.065	0.653GluTrp: 0.653 ± 0.026	1.03GluTyr: 1.03 ± 0.035	0.0GluXaa: 0.0 ± 0.0
Phe	3.991PheAla: 3.991 ± 0.074	0.344PheCys: 0.344 ± 0.019	2.399PheAsp: 2.399 ± 0.046	2.109PheGlu: 2.109 ± 0.049	1.158PhePhe: 1.158 ± 0.037	3.031PheGly: 3.031 ± 0.055	0.694PheHis: 0.694 ± 0.027	1.335PheIle: 1.335 ± 0.037	0.761PheLys: 0.761 ± 0.027	2.896PheLeu: 2.896 ± 0.066	0.665PheMet: 0.665 ± 0.025	0.847PheAsn: 0.847 ± 0.026	1.284PhePro: 1.284 ± 0.037	0.901PheGln: 0.901 ± 0.028	1.908PheArg: 1.908 ± 0.04	1.868PheSer: 1.868 ± 0.044	1.707PheThr: 1.707 ± 0.041	2.453PheVal: 2.453 ± 0.05	0.452PheTrp: 0.452 ± 0.023	0.84PheTyr: 0.84 ± 0.033	0.0PheXaa: 0.0 ± 0.0
Gly	9.697GlyAla: 9.697 ± 0.131	1.161GlyCys: 1.161 ± 0.041	4.371GlyAsp: 4.371 ± 0.07	5.873GlyGlu: 5.873 ± 0.091	3.131GlyPhe: 3.131 ± 0.061	6.753GlyGly: 6.753 ± 0.1	1.967GlyHis: 1.967 ± 0.045	3.981GlyIle: 3.981 ± 0.065	2.003GlyLys: 2.003 ± 0.048	9.691GlyLeu: 9.691 ± 0.117	2.135GlyMet: 2.135 ± 0.051	1.711GlyAsn: 1.711 ± 0.049	2.959GlyPro: 2.959 ± 0.053	2.677GlyGln: 2.677 ± 0.052	6.777GlyArg: 6.777 ± 0.08	3.64GlySer: 3.64 ± 0.057	3.826GlyThr: 3.826 ± 0.084	6.518GlyVal: 6.518 ± 0.077	1.439GlyTrp: 1.439 ± 0.046	2.273GlyTyr: 2.273 ± 0.053	0.0GlyXaa: 0.0 ± 0.0
His	2.927HisAla: 2.927 ± 0.059	0.333HisCys: 0.333 ± 0.018	1.466HisAsp: 1.466 ± 0.036	1.137HisGlu: 1.137 ± 0.035	0.876HisPhe: 0.876 ± 0.027	2.184HisGly: 2.184 ± 0.048	0.843HisHis: 0.843 ± 0.037	0.821HisIle: 0.821 ± 0.028	0.401HisLys: 0.401 ± 0.02	2.585HisLeu: 2.585 ± 0.054	0.385HisMet: 0.385 ± 0.018	0.499HisAsn: 0.499 ± 0.023	1.813HisPro: 1.813 ± 0.045	1.002HisGln: 1.002 ± 0.033	2.019HisArg: 2.019 ± 0.044	0.982HisSer: 0.982 ± 0.031	1.026HisThr: 1.026 ± 0.029	1.356HisVal: 1.356 ± 0.045	0.495HisTrp: 0.495 ± 0.021	0.687HisTyr: 0.687 ± 0.029	0.0HisXaa: 0.0 ± 0.0
Ile	6.408IleAla: 6.408 ± 0.075	0.386IleCys: 0.386 ± 0.019	3.705IleAsp: 3.705 ± 0.058	3.935IleGlu: 3.935 ± 0.066	1.061IlePhe: 1.061 ± 0.034	4.342IleGly: 4.342 ± 0.066	1.075IleHis: 1.075 ± 0.03	1.493IleIle: 1.493 ± 0.043	1.052IleLys: 1.052 ± 0.038	3.969IleLeu: 3.969 ± 0.072	0.644IleMet: 0.644 ± 0.024	1.249IleAsn: 1.249 ± 0.038	2.23IlePro: 2.23 ± 0.046	1.278IleGln: 1.278 ± 0.039	3.164IleArg: 3.164 ± 0.058	2.12IleSer: 2.12 ± 0.05	2.254IleThr: 2.254 ± 0.056	2.729IleVal: 2.729 ± 0.051	0.389IleTrp: 0.389 ± 0.02	0.909IleTyr: 0.909 ± 0.031	0.0IleXaa: 0.0 ± 0.0
Lys	2.137LysAla: 2.137 ± 0.052	0.154LysCys: 0.154 ± 0.012	1.053LysAsp: 1.053 ± 0.033	0.985LysGlu: 0.985 ± 0.039	0.5LysPhe: 0.5 ± 0.022	1.663LysGly: 1.663 ± 0.046	0.465LysHis: 0.465 ± 0.02	0.889LysIle: 0.889 ± 0.031	0.581LysLys: 0.581 ± 0.028	1.971LysLeu: 1.971 ± 0.046	0.383LysMet: 0.383 ± 0.018	0.461LysAsn: 0.461 ± 0.023	1.074LysPro: 1.074 ± 0.035	0.809LysGln: 0.809 ± 0.027	1.877LysArg: 1.877 ± 0.046	1.037LysSer: 1.037 ± 0.031	1.108LysThr: 1.108 ± 0.032	1.512LysVal: 1.512 ± 0.052	0.181LysTrp: 0.181 ± 0.013	0.422LysTyr: 0.422 ± 0.021	0.0LysXaa: 0.0 ± 0.0
Leu	16.832LeuAla: 16.832 ± 0.173	1.141LeuCys: 1.141 ± 0.033	7.941LeuAsp: 7.941 ± 0.084	8.169LeuGlu: 8.169 ± 0.102	3.784LeuPhe: 3.784 ± 0.079	10.29LeuGly: 10.29 ± 0.125	2.497LeuHis: 2.497 ± 0.056	5.395LeuIle: 5.395 ± 0.074	2.209LeuLys: 2.209 ± 0.053	13.892LeuLeu: 13.892 ± 0.208	2.229LeuMet: 2.229 ± 0.05	2.295LeuAsn: 2.295 ± 0.051	6.055LeuPro: 6.055 ± 0.081	3.261LeuGln: 3.261 ± 0.062	9.506LeuArg: 9.506 ± 0.111	5.549LeuSer: 5.549 ± 0.085	5.609LeuThr: 5.609 ± 0.088	9.156LeuVal: 9.156 ± 0.121	1.368LeuTrp: 1.368 ± 0.046	2.406LeuTyr: 2.406 ± 0.052	0.0LeuXaa: 0.0 ± 0.0
Met	2.414MetAla: 2.414 ± 0.049	0.149MetCys: 0.149 ± 0.012	0.971MetAsp: 0.971 ± 0.03	1.016MetGlu: 1.016 ± 0.03	0.526MetPhe: 0.526 ± 0.021	1.403MetGly: 1.403 ± 0.041	0.479MetHis: 0.479 ± 0.02	1.011MetIle: 1.011 ± 0.028	0.538MetLys: 0.538 ± 0.021	2.418MetLeu: 2.418 ± 0.05	0.47MetMet: 0.47 ± 0.024	0.558MetAsn: 0.558 ± 0.024	1.193MetPro: 1.193 ± 0.034	0.738MetGln: 0.738 ± 0.029	1.805MetArg: 1.805 ± 0.044	1.397MetSer: 1.397 ± 0.037	1.382MetThr: 1.382 ± 0.039	1.541MetVal: 1.541 ± 0.039	0.158MetTrp: 0.158 ± 0.012	0.252MetTyr: 0.252 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	2.45AsnAla: 2.45 ± 0.052	0.231AsnCys: 0.231 ± 0.013	1.153AsnAsp: 1.153 ± 0.042	0.9AsnGlu: 0.9 ± 0.029	0.632AsnPhe: 0.632 ± 0.027	1.676AsnGly: 1.676 ± 0.05	0.518AsnHis: 0.518 ± 0.024	0.989AsnIle: 0.989 ± 0.035	0.438AsnLys: 0.438 ± 0.023	2.552AsnLeu: 2.552 ± 0.049	0.426AsnMet: 0.426 ± 0.018	0.511AsnAsn: 0.511 ± 0.025	1.545AsnPro: 1.545 ± 0.04	0.819AsnGln: 0.819 ± 0.028	1.775AsnArg: 1.775 ± 0.041	0.859AsnSer: 0.859 ± 0.029	1.028AsnThr: 1.028 ± 0.031	1.256AsnVal: 1.256 ± 0.036	0.29AsnTrp: 0.29 ± 0.018	0.517AsnTyr: 0.517 ± 0.026	0.0AsnXaa: 0.0 ± 0.0
Pro	6.296ProAla: 6.296 ± 0.091	0.493ProCys: 0.493 ± 0.023	3.378ProAsp: 3.378 ± 0.065	5.142ProGlu: 5.142 ± 0.086	1.694ProPhe: 1.694 ± 0.04	5.078ProGly: 5.078 ± 0.077	1.057ProHis: 1.057 ± 0.032	1.96ProIle: 1.96 ± 0.045	0.95ProLys: 0.95 ± 0.034	5.895ProLeu: 5.895 ± 0.088	0.974ProMet: 0.974 ± 0.027	0.989ProAsn: 0.989 ± 0.027	3.136ProPro: 3.136 ± 0.071	1.666ProGln: 1.666 ± 0.045	3.892ProArg: 3.892 ± 0.071	2.579ProSer: 2.579 ± 0.053	2.439ProThr: 2.439 ± 0.056	3.997ProVal: 3.997 ± 0.057	0.923ProTrp: 0.923 ± 0.035	1.147ProTyr: 1.147 ± 0.039	0.0ProXaa: 0.0 ± 0.0
Gln	4.44GlnAla: 4.44 ± 0.082	0.292GlnCys: 0.292 ± 0.017	1.43GlnAsp: 1.43 ± 0.043	1.582GlnGlu: 1.582 ± 0.044	0.895GlnPhe: 0.895 ± 0.031	2.916GlnGly: 2.916 ± 0.054	0.868GlnHis: 0.868 ± 0.03	1.549GlnIle: 1.549 ± 0.038	0.502GlnLys: 0.502 ± 0.023	4.19GlnLeu: 4.19 ± 0.063	0.62GlnMet: 0.62 ± 0.026	0.515GlnAsn: 0.515 ± 0.021	2.022GlnPro: 2.022 ± 0.049	1.683GlnGln: 1.683 ± 0.047	3.72GlnArg: 3.72 ± 0.065	1.632GlnSer: 1.632 ± 0.039	1.698GlnThr: 1.698 ± 0.044	2.915GlnVal: 2.915 ± 0.056	0.469GlnTrp: 0.469 ± 0.023	0.571GlnTyr: 0.571 ± 0.024	0.0GlnXaa: 0.0 ± 0.0
Arg	11.313ArgAla: 11.313 ± 0.113	0.873ArgCys: 0.873 ± 0.033	4.875ArgAsp: 4.875 ± 0.077	5.677ArgGlu: 5.677 ± 0.079	3.216ArgPhe: 3.216 ± 0.049	5.522ArgGly: 5.522 ± 0.075	2.345ArgHis: 2.345 ± 0.054	4.366ArgIle: 4.366 ± 0.066	1.596ArgLys: 1.596 ± 0.042	11.814ArgLeu: 11.814 ± 0.14	1.921ArgMet: 1.921 ± 0.046	1.614ArgAsn: 1.614 ± 0.04	4.285ArgPro: 4.285 ± 0.066	3.079ArgGln: 3.079 ± 0.055	7.509ArgArg: 7.509 ± 0.105	3.123ArgSer: 3.123 ± 0.066	3.556ArgThr: 3.556 ± 0.055	6.395ArgVal: 6.395 ± 0.094	1.452ArgTrp: 1.452 ± 0.043	2.28ArgTyr: 2.28 ± 0.045	0.0ArgXaa: 0.0 ± 0.0
Ser	5.781SerAla: 5.781 ± 0.093	0.445SerCys: 0.445 ± 0.021	2.489SerAsp: 2.489 ± 0.053	2.602SerGlu: 2.602 ± 0.049	1.487SerPhe: 1.487 ± 0.037	4.84SerGly: 4.84 ± 0.081	1.003SerHis: 1.003 ± 0.029	2.153SerIle: 2.153 ± 0.037	0.862SerLys: 0.862 ± 0.03	5.208SerLeu: 5.208 ± 0.069	1.041SerMet: 1.041 ± 0.033	1.01SerAsn: 1.01 ± 0.037	2.572SerPro: 2.572 ± 0.055	1.404SerGln: 1.404 ± 0.036	3.678SerArg: 3.678 ± 0.065	2.378SerSer: 2.378 ± 0.053	2.425SerThr: 2.425 ± 0.052	3.082SerVal: 3.082 ± 0.05	0.62SerTrp: 0.62 ± 0.023	1.032SerTyr: 1.032 ± 0.031	0.0SerXaa: 0.0 ± 0.0
Thr	5.562ThrAla: 5.562 ± 0.085	0.423ThrCys: 0.423 ± 0.022	2.689ThrAsp: 2.689 ± 0.063	2.932ThrGlu: 2.932 ± 0.057	1.454ThrPhe: 1.454 ± 0.041	4.119ThrGly: 4.119 ± 0.075	1.075ThrHis: 1.075 ± 0.031	2.079ThrIle: 2.079 ± 0.052	0.89ThrLys: 0.89 ± 0.026	7.139ThrLeu: 7.139 ± 0.096	0.84ThrMet: 0.84 ± 0.03	1.004ThrAsn: 1.004 ± 0.033	3.495ThrPro: 3.495 ± 0.06	1.562ThrGln: 1.562 ± 0.04	4.012ThrArg: 4.012 ± 0.06	2.199ThrSer: 2.199 ± 0.058	2.596ThrThr: 2.596 ± 0.064	3.331ThrVal: 3.331 ± 0.063	0.573ThrTrp: 0.573 ± 0.023	0.919ThrTyr: 0.919 ± 0.029	0.0ThrXaa: 0.0 ± 0.0
Val	8.904ValAla: 8.904 ± 0.113	0.782ValCys: 0.782 ± 0.03	4.352ValAsp: 4.352 ± 0.066	5.462ValGlu: 5.462 ± 0.082	2.402ValPhe: 2.402 ± 0.052	5.373ValGly: 5.373 ± 0.065	1.559ValHis: 1.559 ± 0.042	3.429ValIle: 3.429 ± 0.054	1.4ValLys: 1.4 ± 0.043	8.404ValLeu: 8.404 ± 0.102	1.602ValMet: 1.602 ± 0.04	1.641ValAsn: 1.641 ± 0.042	3.322ValPro: 3.322 ± 0.061	1.828ValGln: 1.828 ± 0.044	5.85ValArg: 5.85 ± 0.08	3.721ValSer: 3.721 ± 0.067	3.459ValThr: 3.459 ± 0.061	6.1ValVal: 6.1 ± 0.091	0.851ValTrp: 0.851 ± 0.029	1.526ValTyr: 1.526 ± 0.038	0.0ValXaa: 0.0 ± 0.0
Trp	1.086TrpAla: 1.086 ± 0.033	0.202TrpCys: 0.202 ± 0.013	0.619TrpAsp: 0.619 ± 0.028	0.684TrpGlu: 0.684 ± 0.027	0.521TrpPhe: 0.521 ± 0.025	0.927TrpGly: 0.927 ± 0.03	0.342TrpHis: 0.342 ± 0.018	0.621TrpIle: 0.621 ± 0.023	0.237TrpLys: 0.237 ± 0.014	2.002TrpLeu: 2.002 ± 0.06	0.321TrpMet: 0.321 ± 0.019	0.325TrpAsn: 0.325 ± 0.017	0.702TrpPro: 0.702 ± 0.028	0.628TrpGln: 0.628 ± 0.025	1.571TrpArg: 1.571 ± 0.046	0.862TrpSer: 0.862 ± 0.032	0.623TrpThr: 0.623 ± 0.027	1.079TrpVal: 1.079 ± 0.034	0.271TrpTrp: 0.271 ± 0.018	0.29TrpTyr: 0.29 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.325TyrAla: 2.325 ± 0.048	0.264TyrCys: 0.264 ± 0.017	1.312TyrAsp: 1.312 ± 0.038	1.01TyrGlu: 1.01 ± 0.034	0.788TyrPhe: 0.788 ± 0.026	1.872TyrGly: 1.872 ± 0.044	0.564TyrHis: 0.564 ± 0.023	0.723TyrIle: 0.723 ± 0.027	0.41TyrLys: 0.41 ± 0.019	2.855TyrLeu: 2.855 ± 0.059	0.382TyrMet: 0.382 ± 0.02	0.504TyrAsn: 0.504 ± 0.021	1.199TyrPro: 1.199 ± 0.038	0.889TyrGln: 0.889 ± 0.028	2.41TyrArg: 2.41 ± 0.053	1.058TyrSer: 1.058 ± 0.034	0.952TyrThr: 0.952 ± 0.032	1.464TyrVal: 1.464 ± 0.038	0.354TyrTrp: 0.354 ± 0.02	0.624TyrTyr: 0.624 ± 0.026	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3249 proteins (1091096 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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