Amino acid dipepetide frequency for Halomonas pacifica

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	15.226AlaAla: 15.226 ± 0.168	1.352AlaCys: 1.352 ± 0.037	5.995AlaAsp: 5.995 ± 0.086	9.339AlaGlu: 9.339 ± 0.13	4.198AlaPhe: 4.198 ± 0.069	10.307AlaGly: 10.307 ± 0.13	2.442AlaHis: 2.442 ± 0.051	5.543AlaIle: 5.543 ± 0.073	2.628AlaLys: 2.628 ± 0.061	16.261AlaLeu: 16.261 ± 0.192	3.346AlaMet: 3.346 ± 0.06	2.473AlaAsn: 2.473 ± 0.056	5.984AlaPro: 5.984 ± 0.085	4.35AlaGln: 4.35 ± 0.072	9.594AlaArg: 9.594 ± 0.129	6.334AlaSer: 6.334 ± 0.087	5.405AlaThr: 5.405 ± 0.069	7.615AlaVal: 7.615 ± 0.081	2.306AlaTrp: 2.306 ± 0.051	2.645AlaTyr: 2.645 ± 0.055	0.0AlaXaa: 0.0 ± 0.0
Cys	0.963CysAla: 0.963 ± 0.031	0.133CysCys: 0.133 ± 0.013	0.597CysAsp: 0.597 ± 0.024	0.545CysGlu: 0.545 ± 0.025	0.332CysPhe: 0.332 ± 0.016	0.962CysGly: 0.962 ± 0.036	0.354CysHis: 0.354 ± 0.018	0.32CysIle: 0.32 ± 0.017	0.165CysLys: 0.165 ± 0.012	1.222CysLeu: 1.222 ± 0.039	0.178CysMet: 0.178 ± 0.013	0.191CysAsn: 0.191 ± 0.013	0.534CysPro: 0.534 ± 0.025	0.33CysGln: 0.33 ± 0.018	0.857CysArg: 0.857 ± 0.029	0.43CysSer: 0.43 ± 0.019	0.369CysThr: 0.369 ± 0.018	0.584CysVal: 0.584 ± 0.023	0.153CysTrp: 0.153 ± 0.011	0.269CysTyr: 0.269 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	6.705AspAla: 6.705 ± 0.083	0.486AspCys: 0.486 ± 0.021	3.496AspAsp: 3.496 ± 0.062	4.098AspGlu: 4.098 ± 0.067	2.259AspPhe: 2.259 ± 0.054	4.703AspGly: 4.703 ± 0.07	1.284AspHis: 1.284 ± 0.036	2.334AspIle: 2.334 ± 0.048	1.408AspLys: 1.408 ± 0.04	5.766AspLeu: 5.766 ± 0.077	1.097AspMet: 1.097 ± 0.035	1.292AspAsn: 1.292 ± 0.037	3.238AspPro: 3.238 ± 0.058	1.862AspGln: 1.862 ± 0.046	3.55AspArg: 3.55 ± 0.06	2.484AspSer: 2.484 ± 0.051	2.478AspThr: 2.478 ± 0.055	3.01AspVal: 3.01 ± 0.062	1.053AspTrp: 1.053 ± 0.032	1.761AspTyr: 1.761 ± 0.038	0.0AspXaa: 0.0 ± 0.0
Glu	11.11GluAla: 11.11 ± 0.14	0.491GluCys: 0.491 ± 0.025	2.778GluAsp: 2.778 ± 0.054	4.235GluGlu: 4.235 ± 0.083	1.58GluPhe: 1.58 ± 0.033	5.534GluGly: 5.534 ± 0.073	1.671GluHis: 1.671 ± 0.039	2.996GluIle: 2.996 ± 0.052	1.495GluLys: 1.495 ± 0.045	7.643GluLeu: 7.643 ± 0.094	1.457GluMet: 1.457 ± 0.035	1.234GluAsn: 1.234 ± 0.034	2.954GluPro: 2.954 ± 0.054	2.75GluGln: 2.75 ± 0.065	6.75GluArg: 6.75 ± 0.101	3.053GluSer: 3.053 ± 0.062	3.209GluThr: 3.209 ± 0.055	5.125GluVal: 5.125 ± 0.08	0.835GluTrp: 0.835 ± 0.029	1.112GluTyr: 1.112 ± 0.036	0.0GluXaa: 0.0 ± 0.0
Phe	3.949PheAla: 3.949 ± 0.069	0.4PheCys: 0.4 ± 0.02	2.321PheAsp: 2.321 ± 0.043	2.226PheGlu: 2.226 ± 0.044	1.25PhePhe: 1.25 ± 0.037	3.157PheGly: 3.157 ± 0.06	0.803PheHis: 0.803 ± 0.032	1.384PheIle: 1.384 ± 0.036	0.752PheLys: 0.752 ± 0.027	3.212PheLeu: 3.212 ± 0.059	0.78PheMet: 0.78 ± 0.029	0.899PheAsn: 0.899 ± 0.031	1.463PhePro: 1.463 ± 0.038	1.081PheGln: 1.081 ± 0.029	2.064PheArg: 2.064 ± 0.046	1.968PheSer: 1.968 ± 0.049	1.839PheThr: 1.839 ± 0.043	2.347PheVal: 2.347 ± 0.052	0.496PheTrp: 0.496 ± 0.025	0.953PheTyr: 0.953 ± 0.034	0.0PheXaa: 0.0 ± 0.0
Gly	8.537GlyAla: 8.537 ± 0.104	0.965GlyCys: 0.965 ± 0.031	4.665GlyAsp: 4.665 ± 0.078	6.862GlyGlu: 6.862 ± 0.082	3.246GlyPhe: 3.246 ± 0.049	7.31GlyGly: 7.31 ± 0.117	2.15GlyHis: 2.15 ± 0.046	4.33GlyIle: 4.33 ± 0.062	2.339GlyLys: 2.339 ± 0.049	10.642GlyLeu: 10.642 ± 0.114	2.284GlyMet: 2.284 ± 0.056	1.913GlyAsn: 1.913 ± 0.045	3.105GlyPro: 3.105 ± 0.05	3.381GlyGln: 3.381 ± 0.055	6.551GlyArg: 6.551 ± 0.083	4.117GlySer: 4.117 ± 0.063	3.467GlyThr: 3.467 ± 0.07	6.426GlyVal: 6.426 ± 0.078	1.453GlyTrp: 1.453 ± 0.04	2.417GlyTyr: 2.417 ± 0.044	0.0GlyXaa: 0.0 ± 0.0
His	2.473HisAla: 2.473 ± 0.046	0.306HisCys: 0.306 ± 0.017	1.447HisAsp: 1.447 ± 0.037	1.287HisGlu: 1.287 ± 0.035	1.052HisPhe: 1.052 ± 0.03	2.303HisGly: 2.303 ± 0.045	0.778HisHis: 0.778 ± 0.029	0.833HisIle: 0.833 ± 0.028	0.513HisLys: 0.513 ± 0.021	2.756HisLeu: 2.756 ± 0.047	0.415HisMet: 0.415 ± 0.02	0.509HisAsn: 0.509 ± 0.02	1.681HisPro: 1.681 ± 0.039	0.95HisGln: 0.95 ± 0.031	1.986HisArg: 1.986 ± 0.037	1.056HisSer: 1.056 ± 0.034	0.924HisThr: 0.924 ± 0.03	1.158HisVal: 1.158 ± 0.029	0.457HisTrp: 0.457 ± 0.021	0.813HisTyr: 0.813 ± 0.027	0.0HisXaa: 0.0 ± 0.0
Ile	5.494IleAla: 5.494 ± 0.081	0.395IleCys: 0.395 ± 0.018	3.224IleAsp: 3.224 ± 0.058	3.247IleGlu: 3.247 ± 0.063	1.329IlePhe: 1.329 ± 0.039	3.982IleGly: 3.982 ± 0.066	0.988IleHis: 0.988 ± 0.029	1.736IleIle: 1.736 ± 0.046	1.138IleLys: 1.138 ± 0.034	3.951IleLeu: 3.951 ± 0.078	0.807IleMet: 0.807 ± 0.027	1.32IleAsn: 1.32 ± 0.036	2.059IlePro: 2.059 ± 0.05	1.368IleGln: 1.368 ± 0.037	2.988IleArg: 2.988 ± 0.055	2.241IleSer: 2.241 ± 0.049	2.427IleThr: 2.427 ± 0.051	2.835IleVal: 2.835 ± 0.057	0.423IleTrp: 0.423 ± 0.021	0.936IleTyr: 0.936 ± 0.029	0.0IleXaa: 0.0 ± 0.0
Lys	2.902LysAla: 2.902 ± 0.061	0.162LysCys: 0.162 ± 0.012	0.979LysAsp: 0.979 ± 0.032	1.293LysGlu: 1.293 ± 0.041	0.543LysPhe: 0.543 ± 0.024	1.991LysGly: 1.991 ± 0.054	0.51LysHis: 0.51 ± 0.021	0.907LysIle: 0.907 ± 0.034	0.812LysLys: 0.812 ± 0.036	2.448LysLeu: 2.448 ± 0.058	0.498LysMet: 0.498 ± 0.021	0.502LysAsn: 0.502 ± 0.025	1.252LysPro: 1.252 ± 0.03	0.916LysGln: 0.916 ± 0.03	2.099LysArg: 2.099 ± 0.048	1.188LysSer: 1.188 ± 0.035	1.137LysThr: 1.137 ± 0.031	1.848LysVal: 1.848 ± 0.052	0.224LysTrp: 0.224 ± 0.015	0.452LysTyr: 0.452 ± 0.019	0.0LysXaa: 0.0 ± 0.0
Leu	17.892LeuAla: 17.892 ± 0.215	1.218LeuCys: 1.218 ± 0.042	7.269LeuAsp: 7.269 ± 0.096	8.277LeuGlu: 8.277 ± 0.111	3.758LeuPhe: 3.758 ± 0.075	11.124LeuGly: 11.124 ± 0.132	2.37LeuHis: 2.37 ± 0.046	5.17LeuIle: 5.17 ± 0.078	2.89LeuLys: 2.89 ± 0.058	13.804LeuLeu: 13.804 ± 0.208	2.894LeuMet: 2.894 ± 0.062	2.522LeuAsn: 2.522 ± 0.049	6.847LeuPro: 6.847 ± 0.098	3.011LeuGln: 3.011 ± 0.058	7.906LeuArg: 7.906 ± 0.1	6.522LeuSer: 6.522 ± 0.09	6.084LeuThr: 6.084 ± 0.077	8.796LeuVal: 8.796 ± 0.103	1.623LeuTrp: 1.623 ± 0.044	2.414LeuTyr: 2.414 ± 0.046	0.0LeuXaa: 0.0 ± 0.0
Met	3.058MetAla: 3.058 ± 0.054	0.146MetCys: 0.146 ± 0.011	1.055MetAsp: 1.055 ± 0.033	1.126MetGlu: 1.126 ± 0.033	0.562MetPhe: 0.562 ± 0.024	1.812MetGly: 1.812 ± 0.043	0.518MetHis: 0.518 ± 0.021	1.14MetIle: 1.14 ± 0.037	0.663MetLys: 0.663 ± 0.026	2.552MetLeu: 2.552 ± 0.055	0.553MetMet: 0.553 ± 0.028	0.628MetAsn: 0.628 ± 0.027	1.325MetPro: 1.325 ± 0.039	0.87MetGln: 0.87 ± 0.032	1.603MetArg: 1.603 ± 0.035	1.575MetSer: 1.575 ± 0.033	1.589MetThr: 1.589 ± 0.04	1.565MetVal: 1.565 ± 0.032	0.171MetTrp: 0.171 ± 0.014	0.276MetTyr: 0.276 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	2.625AsnAla: 2.625 ± 0.058	0.182AsnCys: 0.182 ± 0.013	1.248AsnAsp: 1.248 ± 0.037	1.087AsnGlu: 1.087 ± 0.036	0.766AsnPhe: 0.766 ± 0.028	1.865AsnGly: 1.865 ± 0.052	0.515AsnHis: 0.515 ± 0.019	1.051AsnIle: 1.051 ± 0.032	0.458AsnLys: 0.458 ± 0.023	2.481AsnLeu: 2.481 ± 0.054	0.427AsnMet: 0.427 ± 0.021	0.568AsnAsn: 0.568 ± 0.023	1.494AsnPro: 1.494 ± 0.038	0.844AsnGln: 0.844 ± 0.027	1.714AsnArg: 1.714 ± 0.041	0.908AsnSer: 0.908 ± 0.029	1.054AsnThr: 1.054 ± 0.037	1.44AsnVal: 1.44 ± 0.039	0.284AsnTrp: 0.284 ± 0.015	0.57AsnTyr: 0.57 ± 0.021	0.0AsnXaa: 0.0 ± 0.0
Pro	6.024ProAla: 6.024 ± 0.086	0.384ProCys: 0.384 ± 0.019	2.934ProAsp: 2.934 ± 0.053	4.514ProGlu: 4.514 ± 0.066	1.718ProPhe: 1.718 ± 0.039	4.795ProGly: 4.795 ± 0.07	1.137ProHis: 1.137 ± 0.034	1.861ProIle: 1.861 ± 0.041	1.03ProLys: 1.03 ± 0.031	6.419ProLeu: 6.419 ± 0.088	1.221ProMet: 1.221 ± 0.035	0.981ProAsn: 0.981 ± 0.03	2.538ProPro: 2.538 ± 0.057	1.851ProGln: 1.851 ± 0.044	3.847ProArg: 3.847 ± 0.076	2.656ProSer: 2.656 ± 0.057	2.148ProThr: 2.148 ± 0.042	3.675ProVal: 3.675 ± 0.06	0.96ProTrp: 0.96 ± 0.032	1.088ProTyr: 1.088 ± 0.027	0.0ProXaa: 0.0 ± 0.0
Gln	5.976GlnAla: 5.976 ± 0.092	0.274GlnCys: 0.274 ± 0.016	1.549GlnAsp: 1.549 ± 0.042	2.177GlnGlu: 2.177 ± 0.055	0.972GlnPhe: 0.972 ± 0.029	3.543GlnGly: 3.543 ± 0.062	0.807GlnHis: 0.807 ± 0.029	1.217GlnIle: 1.217 ± 0.035	0.679GlnLys: 0.679 ± 0.027	4.039GlnLeu: 4.039 ± 0.068	0.721GlnMet: 0.721 ± 0.025	0.588GlnAsn: 0.588 ± 0.024	1.733GlnPro: 1.733 ± 0.046	1.802GlnGln: 1.802 ± 0.053	3.511GlnArg: 3.511 ± 0.068	1.562GlnSer: 1.562 ± 0.043	1.395GlnThr: 1.395 ± 0.035	2.684GlnVal: 2.684 ± 0.055	0.592GlnTrp: 0.592 ± 0.023	0.644GlnTyr: 0.644 ± 0.02	0.0GlnXaa: 0.0 ± 0.0
Arg	7.582ArgAla: 7.582 ± 0.088	0.687ArgCys: 0.687 ± 0.023	4.5ArgAsp: 4.5 ± 0.069	5.704ArgGlu: 5.704 ± 0.098	2.957ArgPhe: 2.957 ± 0.055	5.525ArgGly: 5.525 ± 0.073	2.592ArgHis: 2.592 ± 0.058	3.266ArgIle: 3.266 ± 0.059	1.452ArgLys: 1.452 ± 0.039	12.177ArgLeu: 12.177 ± 0.154	1.513ArgMet: 1.513 ± 0.038	1.407ArgAsn: 1.407 ± 0.037	3.716ArgPro: 3.716 ± 0.063	3.666ArgGln: 3.666 ± 0.08	7.548ArgArg: 7.548 ± 0.116	2.843ArgSer: 2.843 ± 0.051	2.505ArgThr: 2.505 ± 0.049	5.681ArgVal: 5.681 ± 0.079	1.206ArgTrp: 1.206 ± 0.033	2.17ArgTyr: 2.17 ± 0.044	0.0ArgXaa: 0.0 ± 0.0
Ser	5.167SerAla: 5.167 ± 0.078	0.422SerCys: 0.422 ± 0.022	2.652SerAsp: 2.652 ± 0.055	2.787SerGlu: 2.787 ± 0.054	1.652SerPhe: 1.652 ± 0.042	4.885SerGly: 4.885 ± 0.072	1.228SerHis: 1.228 ± 0.032	1.952SerIle: 1.952 ± 0.047	0.945SerLys: 0.945 ± 0.032	6.682SerLeu: 6.682 ± 0.09	1.133SerMet: 1.133 ± 0.032	1.058SerAsn: 1.058 ± 0.031	2.865SerPro: 2.865 ± 0.055	1.876SerGln: 1.876 ± 0.047	4.196SerArg: 4.196 ± 0.067	2.327SerSer: 2.327 ± 0.057	2.121SerThr: 2.121 ± 0.047	3.32SerVal: 3.32 ± 0.062	0.67SerTrp: 0.67 ± 0.027	1.115SerTyr: 1.115 ± 0.033	0.0SerXaa: 0.0 ± 0.0
Thr	4.951ThrAla: 4.951 ± 0.069	0.395ThrCys: 0.395 ± 0.019	1.988ThrAsp: 1.988 ± 0.048	2.375ThrGlu: 2.375 ± 0.049	1.584ThrPhe: 1.584 ± 0.037	3.904ThrGly: 3.904 ± 0.071	1.089ThrHis: 1.089 ± 0.033	1.804ThrIle: 1.804 ± 0.048	0.844ThrLys: 0.844 ± 0.035	7.273ThrLeu: 7.273 ± 0.091	0.812ThrMet: 0.812 ± 0.028	0.961ThrAsn: 0.961 ± 0.03	3.561ThrPro: 3.561 ± 0.06	1.708ThrGln: 1.708 ± 0.038	3.603ThrArg: 3.603 ± 0.061	2.15ThrSer: 2.15 ± 0.051	2.47ThrThr: 2.47 ± 0.055	2.902ThrVal: 2.902 ± 0.055	0.663ThrTrp: 0.663 ± 0.023	1.025ThrTyr: 1.025 ± 0.031	0.0ThrXaa: 0.0 ± 0.0
Val	8.87ValAla: 8.87 ± 0.081	0.651ValCys: 0.651 ± 0.026	3.817ValAsp: 3.817 ± 0.074	4.979ValGlu: 4.979 ± 0.071	2.222ValPhe: 2.222 ± 0.048	5.391ValGly: 5.391 ± 0.076	1.368ValHis: 1.368 ± 0.037	3.715ValIle: 3.715 ± 0.062	1.712ValLys: 1.712 ± 0.051	7.44ValLeu: 7.44 ± 0.107	1.925ValMet: 1.925 ± 0.042	1.716ValAsn: 1.716 ± 0.041	3.381ValPro: 3.381 ± 0.062	1.957ValGln: 1.957 ± 0.043	4.459ValArg: 4.459 ± 0.067	3.832ValSer: 3.832 ± 0.067	3.926ValThr: 3.926 ± 0.066	5.623ValVal: 5.623 ± 0.079	0.787ValTrp: 0.787 ± 0.027	1.39ValTyr: 1.39 ± 0.039	0.0ValXaa: 0.0 ± 0.0
Trp	1.311TrpAla: 1.311 ± 0.037	0.18TrpCys: 0.18 ± 0.012	0.579TrpAsp: 0.579 ± 0.022	0.734TrpGlu: 0.734 ± 0.028	0.498TrpPhe: 0.498 ± 0.021	1.028TrpGly: 1.028 ± 0.033	0.442TrpHis: 0.442 ± 0.018	0.579TrpIle: 0.579 ± 0.023	0.321TrpLys: 0.321 ± 0.016	2.631TrpLeu: 2.631 ± 0.06	0.335TrpMet: 0.335 ± 0.017	0.326TrpAsn: 0.326 ± 0.017	0.778TrpPro: 0.778 ± 0.029	0.909TrpGln: 0.909 ± 0.028	1.442TrpArg: 1.442 ± 0.041	0.75TrpSer: 0.75 ± 0.024	0.541TrpThr: 0.541 ± 0.023	1.046TrpVal: 1.046 ± 0.026	0.299TrpTrp: 0.299 ± 0.018	0.304TrpTyr: 0.304 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.528TyrAla: 2.528 ± 0.051	0.257TyrCys: 0.257 ± 0.015	1.269TyrAsp: 1.269 ± 0.037	1.121TyrGlu: 1.121 ± 0.032	0.867TyrPhe: 0.867 ± 0.03	2.042TyrGly: 2.042 ± 0.04	0.651TyrHis: 0.651 ± 0.026	0.751TyrIle: 0.751 ± 0.028	0.42TyrLys: 0.42 ± 0.022	2.994TyrLeu: 2.994 ± 0.057	0.389TyrMet: 0.389 ± 0.021	0.494TyrAsn: 0.494 ± 0.019	1.275TyrPro: 1.275 ± 0.036	0.98TyrGln: 0.98 ± 0.028	2.426TyrArg: 2.426 ± 0.053	1.054TyrSer: 1.054 ± 0.032	0.973TyrThr: 0.973 ± 0.033	1.483TyrVal: 1.483 ± 0.036	0.379TyrTrp: 0.379 ± 0.021	0.67TyrTyr: 0.67 ± 0.028	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3562 proteins (1139457 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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