Amino acid dipepetide frequency for Corynebacterium pseudotuberculosis (strain C231)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	13.242AlaAla: 13.242 ± 0.204	0.975AlaCys: 0.975 ± 0.039	6.032AlaAsp: 6.032 ± 0.106	7.136AlaGlu: 7.136 ± 0.139	3.676AlaPhe: 3.676 ± 0.078	8.809AlaGly: 8.809 ± 0.12	2.539AlaHis: 2.539 ± 0.065	5.936AlaIle: 5.936 ± 0.106	3.996AlaLys: 3.996 ± 0.084	11.23AlaLeu: 11.23 ± 0.147	2.61AlaMet: 2.61 ± 0.068	2.841AlaAsn: 2.841 ± 0.064	4.633AlaPro: 4.633 ± 0.109	4.16AlaGln: 4.16 ± 0.078	6.099AlaArg: 6.099 ± 0.106	6.412AlaSer: 6.412 ± 0.095	6.406AlaThr: 6.406 ± 0.108	8.785AlaVal: 8.785 ± 0.136	1.451AlaTrp: 1.451 ± 0.045	2.236AlaTyr: 2.236 ± 0.053	0.0AlaXaa: 0.0 ± 0.0
Cys	0.923CysAla: 0.923 ± 0.037	0.1CysCys: 0.1 ± 0.012	0.512CysAsp: 0.512 ± 0.031	0.481CysGlu: 0.481 ± 0.031	0.268CysPhe: 0.268 ± 0.021	0.887CysGly: 0.887 ± 0.037	0.202CysHis: 0.202 ± 0.02	0.432CysIle: 0.432 ± 0.024	0.209CysLys: 0.209 ± 0.019	0.614CysLeu: 0.614 ± 0.039	0.161CysMet: 0.161 ± 0.017	0.214CysAsn: 0.214 ± 0.017	0.403CysPro: 0.403 ± 0.031	0.214CysGln: 0.214 ± 0.018	0.359CysArg: 0.359 ± 0.024	0.626CysSer: 0.626 ± 0.033	0.493CysThr: 0.493 ± 0.027	0.72CysVal: 0.72 ± 0.033	0.096CysTrp: 0.096 ± 0.012	0.167CysTyr: 0.167 ± 0.018	0.0CysXaa: 0.0 ± 0.0
Asp	6.532AspAla: 6.532 ± 0.1	0.444AspCys: 0.444 ± 0.028	2.918AspAsp: 2.918 ± 0.078	3.362AspGlu: 3.362 ± 0.083	2.069AspPhe: 2.069 ± 0.056	4.254AspGly: 4.254 ± 0.098	1.278AspHis: 1.278 ± 0.043	3.274AspIle: 3.274 ± 0.069	2.144AspLys: 2.144 ± 0.052	5.341AspLeu: 5.341 ± 0.095	1.164AspMet: 1.164 ± 0.042	1.736AspAsn: 1.736 ± 0.052	3.467AspPro: 3.467 ± 0.066	1.816AspGln: 1.816 ± 0.054	3.177AspArg: 3.177 ± 0.077	3.75AspSer: 3.75 ± 0.072	2.848AspThr: 2.848 ± 0.06	4.516AspVal: 4.516 ± 0.099	0.716AspTrp: 0.716 ± 0.036	1.501AspTyr: 1.501 ± 0.051	0.0AspXaa: 0.0 ± 0.0
Glu	6.249GluAla: 6.249 ± 0.114	0.431GluCys: 0.431 ± 0.027	3.255GluAsp: 3.255 ± 0.081	4.298GluGlu: 4.298 ± 0.116	1.966GluPhe: 1.966 ± 0.05	4.225GluGly: 4.225 ± 0.092	1.539GluHis: 1.539 ± 0.054	3.625GluIle: 3.625 ± 0.073	3.194GluLys: 3.194 ± 0.09	6.503GluLeu: 6.503 ± 0.115	1.152GluMet: 1.152 ± 0.047	2.174GluAsn: 2.174 ± 0.055	2.48GluPro: 2.48 ± 0.06	2.542GluGln: 2.542 ± 0.068	3.697GluArg: 3.697 ± 0.083	3.547GluSer: 3.547 ± 0.072	3.217GluThr: 3.217 ± 0.071	4.466GluVal: 4.466 ± 0.096	0.738GluTrp: 0.738 ± 0.033	1.395GluTyr: 1.395 ± 0.051	0.0GluXaa: 0.0 ± 0.0
Phe	3.631PheAla: 3.631 ± 0.075	0.305PheCys: 0.305 ± 0.023	2.275PheAsp: 2.275 ± 0.061	1.787PheGlu: 1.787 ± 0.053	1.372PhePhe: 1.372 ± 0.051	3.326PheGly: 3.326 ± 0.07	0.81PheHis: 0.81 ± 0.037	1.918PheIle: 1.918 ± 0.056	1.051PheLys: 1.051 ± 0.038	3.293PheLeu: 3.293 ± 0.067	0.667PheMet: 0.667 ± 0.032	1.219PheAsn: 1.219 ± 0.039	1.569PhePro: 1.569 ± 0.049	0.914PheGln: 0.914 ± 0.034	1.567PheArg: 1.567 ± 0.049	2.641PheSer: 2.641 ± 0.069	2.172PheThr: 2.172 ± 0.069	2.798PheVal: 2.798 ± 0.064	0.423PheTrp: 0.423 ± 0.031	0.826PheTyr: 0.826 ± 0.037	0.0PheXaa: 0.0 ± 0.0
Gly	8.144GlyAla: 8.144 ± 0.112	0.708GlyCys: 0.708 ± 0.038	4.007GlyAsp: 4.007 ± 0.083	4.713GlyGlu: 4.713 ± 0.096	3.202GlyPhe: 3.202 ± 0.081	6.146GlyGly: 6.146 ± 0.125	1.859GlyHis: 1.859 ± 0.056	5.37GlyIle: 5.37 ± 0.107	3.807GlyLys: 3.807 ± 0.087	7.778GlyLeu: 7.778 ± 0.118	2.095GlyMet: 2.095 ± 0.061	2.421GlyAsn: 2.421 ± 0.064	2.888GlyPro: 2.888 ± 0.065	2.548GlyGln: 2.548 ± 0.072	4.508GlyArg: 4.508 ± 0.084	5.088GlySer: 5.088 ± 0.099	5.044GlyThr: 5.044 ± 0.087	6.791GlyVal: 6.791 ± 0.106	1.245GlyTrp: 1.245 ± 0.039	2.159GlyTyr: 2.159 ± 0.065	0.0GlyXaa: 0.0 ± 0.0
His	2.33HisAla: 2.33 ± 0.06	0.229HisCys: 0.229 ± 0.016	1.364HisAsp: 1.364 ± 0.047	1.26HisGlu: 1.26 ± 0.04	0.756HisPhe: 0.756 ± 0.031	1.849HisGly: 1.849 ± 0.053	0.635HisHis: 0.635 ± 0.03	1.255HisIle: 1.255 ± 0.045	0.719HisLys: 0.719 ± 0.038	1.953HisLeu: 1.953 ± 0.053	0.517HisMet: 0.517 ± 0.03	0.784HisAsn: 0.784 ± 0.036	1.428HisPro: 1.428 ± 0.05	0.749HisGln: 0.749 ± 0.033	1.47HisArg: 1.47 ± 0.051	1.454HisSer: 1.454 ± 0.045	1.349HisThr: 1.349 ± 0.051	1.674HisVal: 1.674 ± 0.055	0.291HisTrp: 0.291 ± 0.021	0.564HisTyr: 0.564 ± 0.031	0.0HisXaa: 0.0 ± 0.0
Ile	7.239IleAla: 7.239 ± 0.113	0.494IleCys: 0.494 ± 0.025	3.879IleAsp: 3.879 ± 0.08	3.247IleGlu: 3.247 ± 0.069	1.893IlePhe: 1.893 ± 0.055	4.825IleGly: 4.825 ± 0.092	1.093IleHis: 1.093 ± 0.044	3.102IleIle: 3.102 ± 0.089	1.971IleLys: 1.971 ± 0.057	4.845IleLeu: 4.845 ± 0.101	1.117IleMet: 1.117 ± 0.043	1.857IleAsn: 1.857 ± 0.049	3.127IlePro: 3.127 ± 0.072	1.563IleGln: 1.563 ± 0.056	2.944IleArg: 2.944 ± 0.071	3.763IleSer: 3.763 ± 0.083	3.794IleThr: 3.794 ± 0.086	4.919IleVal: 4.919 ± 0.092	0.547IleTrp: 0.547 ± 0.031	1.11IleTyr: 1.11 ± 0.045	0.0IleXaa: 0.0 ± 0.0
Lys	3.941LysAla: 3.941 ± 0.085	0.162LysCys: 0.162 ± 0.016	2.445LysAsp: 2.445 ± 0.07	2.614LysGlu: 2.614 ± 0.078	1.076LysPhe: 1.076 ± 0.044	2.656LysGly: 2.656 ± 0.067	0.834LysHis: 0.834 ± 0.036	2.282LysIle: 2.282 ± 0.054	2.309LysLys: 2.309 ± 0.076	3.661LysLeu: 3.661 ± 0.083	0.878LysMet: 0.878 ± 0.037	1.668LysAsn: 1.668 ± 0.059	1.827LysPro: 1.827 ± 0.066	1.404LysGln: 1.404 ± 0.048	2.262LysArg: 2.262 ± 0.061	2.084LysSer: 2.084 ± 0.059	2.539LysThr: 2.539 ± 0.062	3.053LysVal: 3.053 ± 0.081	0.459LysTrp: 0.459 ± 0.029	0.81LysTyr: 0.81 ± 0.038	0.0LysXaa: 0.0 ± 0.0
Leu	11.117LeuAla: 11.117 ± 0.135	0.85LeuCys: 0.85 ± 0.045	5.691LeuAsp: 5.691 ± 0.094	5.041LeuGlu: 5.041 ± 0.095	3.147LeuPhe: 3.147 ± 0.076	8.527LeuGly: 8.527 ± 0.137	2.044LeuHis: 2.044 ± 0.054	5.702LeuIle: 5.702 ± 0.093	3.35LeuLys: 3.35 ± 0.081	9.278LeuLeu: 9.278 ± 0.146	2.015LeuMet: 2.015 ± 0.055	2.858LeuAsn: 2.858 ± 0.066	5.053LeuPro: 5.053 ± 0.104	2.695LeuGln: 2.695 ± 0.068	5.952LeuArg: 5.952 ± 0.085	6.82LeuSer: 6.82 ± 0.1	5.612LeuThr: 5.612 ± 0.082	7.777LeuVal: 7.777 ± 0.123	1.184LeuTrp: 1.184 ± 0.051	1.904LeuTyr: 1.904 ± 0.052	0.0LeuXaa: 0.0 ± 0.0
Met	2.412MetAla: 2.412 ± 0.07	0.208MetCys: 0.208 ± 0.017	1.005MetAsp: 1.005 ± 0.035	1.085MetGlu: 1.085 ± 0.044	0.761MetPhe: 0.761 ± 0.035	1.743MetGly: 1.743 ± 0.055	0.503MetHis: 0.503 ± 0.024	1.364MetIle: 1.364 ± 0.052	0.826MetLys: 0.826 ± 0.034	2.203MetLeu: 2.203 ± 0.055	0.528MetMet: 0.528 ± 0.031	0.778MetAsn: 0.778 ± 0.033	1.154MetPro: 1.154 ± 0.044	0.699MetGln: 0.699 ± 0.028	1.451MetArg: 1.451 ± 0.046	1.762MetSer: 1.762 ± 0.051	1.514MetThr: 1.514 ± 0.046	1.654MetVal: 1.654 ± 0.052	0.293MetTrp: 0.293 ± 0.022	0.396MetTyr: 0.396 ± 0.021	0.0MetXaa: 0.0 ± 0.0
Asn	3.37AsnAla: 3.37 ± 0.075	0.203AsnCys: 0.203 ± 0.017	1.63AsnAsp: 1.63 ± 0.058	1.657AsnGlu: 1.657 ± 0.047	1.098AsnPhe: 1.098 ± 0.045	2.474AsnGly: 2.474 ± 0.059	0.675AsnHis: 0.675 ± 0.032	1.833AsnIle: 1.833 ± 0.053	1.366AsnLys: 1.366 ± 0.047	2.823AsnLeu: 2.823 ± 0.064	0.647AsnMet: 0.647 ± 0.031	1.182AsnAsn: 1.182 ± 0.046	2.091AsnPro: 2.091 ± 0.063	1.073AsnGln: 1.073 ± 0.044	1.719AsnArg: 1.719 ± 0.055	1.993AsnSer: 1.993 ± 0.055	1.813AsnThr: 1.813 ± 0.058	2.336AsnVal: 2.336 ± 0.054	0.405AsnTrp: 0.405 ± 0.025	0.82AsnTyr: 0.82 ± 0.033	0.0AsnXaa: 0.0 ± 0.0
Pro	4.863ProAla: 4.863 ± 0.089	0.29ProCys: 0.29 ± 0.023	2.77ProAsp: 2.77 ± 0.067	4.076ProGlu: 4.076 ± 0.08	1.643ProPhe: 1.643 ± 0.053	3.829ProGly: 3.829 ± 0.085	1.317ProHis: 1.317 ± 0.042	2.385ProIle: 2.385 ± 0.062	1.775ProLys: 1.775 ± 0.062	4.36ProLeu: 4.36 ± 0.089	1.014ProMet: 1.014 ± 0.04	1.502ProAsn: 1.502 ± 0.044	1.751ProPro: 1.751 ± 0.066	1.945ProGln: 1.945 ± 0.056	2.609ProArg: 2.609 ± 0.063	3.093ProSer: 3.093 ± 0.072	3.173ProThr: 3.173 ± 0.074	4.205ProVal: 4.205 ± 0.078	0.682ProTrp: 0.682 ± 0.034	1.114ProTyr: 1.114 ± 0.048	0.0ProXaa: 0.0 ± 0.0
Gln	3.616GlnAla: 3.616 ± 0.065	0.191GlnCys: 0.191 ± 0.018	1.587GlnAsp: 1.587 ± 0.044	2.197GlnGlu: 2.197 ± 0.072	0.911GlnPhe: 0.911 ± 0.041	2.527GlnGly: 2.527 ± 0.063	0.767GlnHis: 0.767 ± 0.036	1.863GlnIle: 1.863 ± 0.057	1.463GlnLys: 1.463 ± 0.044	3.617GlnLeu: 3.617 ± 0.08	0.767GlnMet: 0.767 ± 0.036	1.019GlnAsn: 1.019 ± 0.04	1.654GlnPro: 1.654 ± 0.047	1.519GlnGln: 1.519 ± 0.056	2.661GlnArg: 2.661 ± 0.067	1.904GlnSer: 1.904 ± 0.056	1.605GlnThr: 1.605 ± 0.057	2.383GlnVal: 2.383 ± 0.059	0.612GlnTrp: 0.612 ± 0.031	0.661GlnTyr: 0.661 ± 0.035	0.0GlnXaa: 0.0 ± 0.0
Arg	5.727ArgAla: 5.727 ± 0.098	0.427ArgCys: 0.427 ± 0.027	3.135ArgAsp: 3.135 ± 0.077	3.805ArgGlu: 3.805 ± 0.082	1.983ArgPhe: 1.983 ± 0.058	4.378ArgGly: 4.378 ± 0.088	1.248ArgHis: 1.248 ± 0.047	3.558ArgIle: 3.558 ± 0.081	2.456ArgLys: 2.456 ± 0.062	5.397ArgLeu: 5.397 ± 0.096	1.549ArgMet: 1.549 ± 0.047	1.934ArgAsn: 1.934 ± 0.056	2.591ArgPro: 2.591 ± 0.071	1.903ArgGln: 1.903 ± 0.05	4.487ArgArg: 4.487 ± 0.106	3.603ArgSer: 3.603 ± 0.076	3.25ArgThr: 3.25 ± 0.067	4.328ArgVal: 4.328 ± 0.091	0.861ArgTrp: 0.861 ± 0.032	1.524ArgTyr: 1.524 ± 0.045	0.0ArgXaa: 0.0 ± 0.0
Ser	6.743SerAla: 6.743 ± 0.104	0.488SerCys: 0.488 ± 0.029	3.549SerAsp: 3.549 ± 0.074	3.796SerGlu: 3.796 ± 0.08	2.345SerPhe: 2.345 ± 0.062	5.815SerGly: 5.815 ± 0.09	1.461SerHis: 1.461 ± 0.051	3.487SerIle: 3.487 ± 0.085	2.304SerLys: 2.304 ± 0.063	6.32SerLeu: 6.32 ± 0.087	1.607SerMet: 1.607 ± 0.047	1.742SerAsn: 1.742 ± 0.052	3.058SerPro: 3.058 ± 0.071	2.372SerGln: 2.372 ± 0.069	3.582SerArg: 3.582 ± 0.077	4.596SerSer: 4.596 ± 0.107	3.992SerThr: 3.992 ± 0.075	5.201SerVal: 5.201 ± 0.083	0.951SerTrp: 0.951 ± 0.05	1.589SerTyr: 1.589 ± 0.059	0.0SerXaa: 0.0 ± 0.0
Thr	6.391ThrAla: 6.391 ± 0.11	0.526ThrCys: 0.526 ± 0.03	3.267ThrAsp: 3.267 ± 0.068	3.27ThrGlu: 3.27 ± 0.066	2.109ThrPhe: 2.109 ± 0.06	5.0ThrGly: 5.0 ± 0.088	1.364ThrHis: 1.364 ± 0.046	3.271ThrIle: 3.271 ± 0.072	2.156ThrLys: 2.156 ± 0.061	5.715ThrLeu: 5.715 ± 0.093	1.308ThrMet: 1.308 ± 0.044	1.743ThrAsn: 1.743 ± 0.05	3.57ThrPro: 3.57 ± 0.079	1.895ThrGln: 1.895 ± 0.049	3.002ThrArg: 3.002 ± 0.064	3.834ThrSer: 3.834 ± 0.08	3.802ThrThr: 3.802 ± 0.088	5.238ThrVal: 5.238 ± 0.086	0.882ThrTrp: 0.882 ± 0.043	1.311ThrTyr: 1.311 ± 0.039	0.0ThrXaa: 0.0 ± 0.0
Val	9.038ValAla: 9.038 ± 0.137	0.737ValCys: 0.737 ± 0.03	5.012ValAsp: 5.012 ± 0.092	4.904ValGlu: 4.904 ± 0.098	2.868ValPhe: 2.868 ± 0.064	6.341ValGly: 6.341 ± 0.126	1.754ValHis: 1.754 ± 0.05	4.904ValIle: 4.904 ± 0.087	2.598ValLys: 2.598 ± 0.08	7.912ValLeu: 7.912 ± 0.116	1.742ValMet: 1.742 ± 0.055	2.386ValAsn: 2.386 ± 0.078	3.907ValPro: 3.907 ± 0.077	2.078ValGln: 2.078 ± 0.052	4.34ValArg: 4.34 ± 0.08	5.524ValSer: 5.524 ± 0.096	5.039ValThr: 5.039 ± 0.11	7.311ValVal: 7.311 ± 0.121	0.919ValTrp: 0.919 ± 0.036	1.567ValTyr: 1.567 ± 0.049	0.0ValXaa: 0.0 ± 0.0
Trp	1.361TrpAla: 1.361 ± 0.053	0.121TrpCys: 0.121 ± 0.012	0.705TrpAsp: 0.705 ± 0.033	0.725TrpGlu: 0.725 ± 0.037	0.561TrpPhe: 0.561 ± 0.032	0.916TrpGly: 0.916 ± 0.039	0.282TrpHis: 0.282 ± 0.021	0.766TrpIle: 0.766 ± 0.04	0.534TrpLys: 0.534 ± 0.034	1.505TrpLeu: 1.505 ± 0.054	0.379TrpMet: 0.379 ± 0.024	0.462TrpAsn: 0.462 ± 0.026	0.57TrpPro: 0.57 ± 0.03	0.555TrpGln: 0.555 ± 0.025	0.84TrpArg: 0.84 ± 0.036	0.837TrpSer: 0.837 ± 0.037	0.694TrpThr: 0.694 ± 0.033	1.019TrpVal: 1.019 ± 0.046	0.332TrpTrp: 0.332 ± 0.024	0.29TrpTyr: 0.29 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.336TyrAla: 2.336 ± 0.057	0.191TyrCys: 0.191 ± 0.017	1.27TyrAsp: 1.27 ± 0.051	1.24TyrGlu: 1.24 ± 0.048	0.858TyrPhe: 0.858 ± 0.036	1.99TyrGly: 1.99 ± 0.06	0.427TyrHis: 0.427 ± 0.03	1.007TyrIle: 1.007 ± 0.044	0.737TyrLys: 0.737 ± 0.036	2.268TyrLeu: 2.268 ± 0.058	0.418TyrMet: 0.418 ± 0.025	0.688TyrAsn: 0.688 ± 0.034	1.178TyrPro: 1.178 ± 0.038	0.879TyrGln: 0.879 ± 0.037	1.417TyrArg: 1.417 ± 0.051	1.666TyrSer: 1.666 ± 0.057	1.296TyrThr: 1.296 ± 0.052	1.707TyrVal: 1.707 ± 0.056	0.367TyrTrp: 0.367 ± 0.025	0.553TyrTyr: 0.553 ± 0.03	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2001 proteins (659651 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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