Amino acid dipepetide frequency for Catenovulum agarivorans DS-2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.493AlaAla: 7.493 ± 0.106	0.988AlaCys: 0.988 ± 0.029	5.454AlaAsp: 5.454 ± 0.069	5.963AlaGlu: 5.963 ± 0.075	3.352AlaPhe: 3.352 ± 0.052	5.728AlaGly: 5.728 ± 0.081	1.737AlaHis: 1.737 ± 0.035	5.778AlaIle: 5.778 ± 0.07	5.331AlaLys: 5.331 ± 0.076	8.741AlaLeu: 8.741 ± 0.104	2.023AlaMet: 2.023 ± 0.045	4.533AlaAsn: 4.533 ± 0.068	2.635AlaPro: 2.635 ± 0.056	4.727AlaGln: 4.727 ± 0.07	3.264AlaArg: 3.264 ± 0.055	5.32AlaSer: 5.32 ± 0.065	4.394AlaThr: 4.394 ± 0.064	5.622AlaVal: 5.622 ± 0.075	0.965AlaTrp: 0.965 ± 0.027	2.656AlaTyr: 2.656 ± 0.047	0.0AlaXaa: 0.0 ± 0.0
Cys	0.801CysAla: 0.801 ± 0.022	0.164CysCys: 0.164 ± 0.011	0.515CysAsp: 0.515 ± 0.019	0.533CysGlu: 0.533 ± 0.019	0.45CysPhe: 0.45 ± 0.019	0.789CysGly: 0.789 ± 0.027	0.301CysHis: 0.301 ± 0.019	0.605CysIle: 0.605 ± 0.023	0.461CysLys: 0.461 ± 0.017	1.012CysLeu: 1.012 ± 0.027	0.184CysMet: 0.184 ± 0.012	0.422CysAsn: 0.422 ± 0.021	0.392CysPro: 0.392 ± 0.02	0.558CysGln: 0.558 ± 0.021	0.416CysArg: 0.416 ± 0.02	0.651CysSer: 0.651 ± 0.022	0.438CysThr: 0.438 ± 0.019	0.612CysVal: 0.612 ± 0.019	0.117CysTrp: 0.117 ± 0.01	0.348CysTyr: 0.348 ± 0.018	0.0CysXaa: 0.0 ± 0.0
Asp	4.398AspAla: 4.398 ± 0.058	0.544AspCys: 0.544 ± 0.02	3.26AspAsp: 3.26 ± 0.075	3.666AspGlu: 3.666 ± 0.065	2.79AspPhe: 2.79 ± 0.044	4.003AspGly: 4.003 ± 0.078	0.981AspHis: 0.981 ± 0.032	4.333AspIle: 4.333 ± 0.064	3.755AspLys: 3.755 ± 0.056	5.347AspLeu: 5.347 ± 0.071	1.387AspMet: 1.387 ± 0.035	3.052AspAsn: 3.052 ± 0.054	2.009AspPro: 2.009 ± 0.051	2.04AspGln: 2.04 ± 0.037	1.848AspArg: 1.848 ± 0.039	3.621AspSer: 3.621 ± 0.065	2.828AspThr: 2.828 ± 0.055	3.808AspVal: 3.808 ± 0.065	0.966AspTrp: 0.966 ± 0.025	2.302AspTyr: 2.302 ± 0.039	0.0AspXaa: 0.0 ± 0.0
Glu	4.406GluAla: 4.406 ± 0.062	0.445GluCys: 0.445 ± 0.019	2.682GluAsp: 2.682 ± 0.053	3.007GluGlu: 3.007 ± 0.058	2.721GluPhe: 2.721 ± 0.048	2.884GluGly: 2.884 ± 0.056	1.636GluHis: 1.636 ± 0.041	3.845GluIle: 3.845 ± 0.057	3.535GluLys: 3.535 ± 0.051	6.945GluLeu: 6.945 ± 0.074	1.409GluMet: 1.409 ± 0.036	2.944GluAsn: 2.944 ± 0.052	1.907GluPro: 1.907 ± 0.063	4.785GluGln: 4.785 ± 0.078	2.635GluArg: 2.635 ± 0.053	3.39GluSer: 3.39 ± 0.053	2.87GluThr: 2.87 ± 0.051	3.9GluVal: 3.9 ± 0.062	0.71GluTrp: 0.71 ± 0.027	2.033GluTyr: 2.033 ± 0.043	0.0GluXaa: 0.0 ± 0.0
Phe	4.049PheAla: 4.049 ± 0.05	0.474PheCys: 0.474 ± 0.019	3.146PheAsp: 3.146 ± 0.052	2.751PheGlu: 2.751 ± 0.04	1.66PhePhe: 1.66 ± 0.048	2.892PheGly: 2.892 ± 0.048	0.726PheHis: 0.726 ± 0.026	2.842PheIle: 2.842 ± 0.049	2.406PheLys: 2.406 ± 0.05	3.123PheLeu: 3.123 ± 0.054	0.902PheMet: 0.902 ± 0.025	2.519PheAsn: 2.519 ± 0.041	1.33PhePro: 1.33 ± 0.035	1.268PheGln: 1.268 ± 0.027	1.42PheArg: 1.42 ± 0.032	3.478PheSer: 3.478 ± 0.054	2.444PheThr: 2.444 ± 0.042	2.995PheVal: 2.995 ± 0.049	0.568PheTrp: 0.568 ± 0.021	1.542PheTyr: 1.542 ± 0.034	0.0PheXaa: 0.0 ± 0.0
Gly	4.651GlyAla: 4.651 ± 0.071	0.815GlyCys: 0.815 ± 0.025	3.631GlyAsp: 3.631 ± 0.066	3.983GlyGlu: 3.983 ± 0.062	3.2GlyPhe: 3.2 ± 0.056	4.326GlyGly: 4.326 ± 0.074	1.445GlyHis: 1.445 ± 0.035	4.288GlyIle: 4.288 ± 0.066	3.889GlyLys: 3.889 ± 0.058	6.32GlyLeu: 6.32 ± 0.079	1.527GlyMet: 1.527 ± 0.033	2.781GlyAsn: 2.781 ± 0.063	1.506GlyPro: 1.506 ± 0.04	3.079GlyGln: 3.079 ± 0.049	2.678GlyArg: 2.678 ± 0.054	3.781GlySer: 3.781 ± 0.061	3.17GlyThr: 3.17 ± 0.063	4.514GlyVal: 4.514 ± 0.063	0.968GlyTrp: 0.968 ± 0.029	2.608GlyTyr: 2.608 ± 0.044	0.0GlyXaa: 0.0 ± 0.0
His	1.692HisAla: 1.692 ± 0.043	0.286HisCys: 0.286 ± 0.013	1.084HisAsp: 1.084 ± 0.031	1.043HisGlu: 1.043 ± 0.029	1.077HisPhe: 1.077 ± 0.032	1.393HisGly: 1.393 ± 0.039	0.582HisHis: 0.582 ± 0.023	1.535HisIle: 1.535 ± 0.032	1.408HisLys: 1.408 ± 0.037	2.141HisLeu: 2.141 ± 0.041	0.512HisMet: 0.512 ± 0.021	1.145HisAsn: 1.145 ± 0.037	1.111HisPro: 1.111 ± 0.03	1.345HisGln: 1.345 ± 0.034	0.846HisArg: 0.846 ± 0.024	1.461HisSer: 1.461 ± 0.033	1.091HisThr: 1.091 ± 0.03	1.22HisVal: 1.22 ± 0.03	0.403HisTrp: 0.403 ± 0.018	0.923HisTyr: 0.923 ± 0.028	0.0HisXaa: 0.0 ± 0.0
Ile	6.101IleAla: 6.101 ± 0.086	0.704IleCys: 0.704 ± 0.024	4.543IleAsp: 4.543 ± 0.058	5.049IleGlu: 5.049 ± 0.055	2.288IlePhe: 2.288 ± 0.046	4.352IleGly: 4.352 ± 0.069	1.325IleHis: 1.325 ± 0.035	3.454IleIle: 3.454 ± 0.059	3.938IleLys: 3.938 ± 0.048	5.119IleLeu: 5.119 ± 0.073	1.137IleMet: 1.137 ± 0.033	3.532IleAsn: 3.532 ± 0.055	2.346IlePro: 2.346 ± 0.045	2.793IleGln: 2.793 ± 0.048	2.678IleArg: 2.678 ± 0.052	4.52IleSer: 4.52 ± 0.068	3.593IleThr: 3.593 ± 0.054	4.126IleVal: 4.126 ± 0.062	0.719IleTrp: 0.719 ± 0.023	1.953IleTyr: 1.953 ± 0.042	0.0IleXaa: 0.0 ± 0.0
Lys	4.863LysAla: 4.863 ± 0.069	0.369LysCys: 0.369 ± 0.021	2.721LysAsp: 2.721 ± 0.046	2.694LysGlu: 2.694 ± 0.05	2.156LysPhe: 2.156 ± 0.042	3.094LysGly: 3.094 ± 0.05	1.548LysHis: 1.548 ± 0.032	3.49LysIle: 3.49 ± 0.048	3.051LysLys: 3.051 ± 0.065	6.442LysLeu: 6.442 ± 0.082	1.277LysMet: 1.277 ± 0.03	2.72LysAsn: 2.72 ± 0.049	2.554LysPro: 2.554 ± 0.045	4.034LysGln: 4.034 ± 0.069	2.597LysArg: 2.597 ± 0.051	3.443LysSer: 3.443 ± 0.057	3.083LysThr: 3.083 ± 0.051	3.977LysVal: 3.977 ± 0.064	0.698LysTrp: 0.698 ± 0.024	1.766LysTyr: 1.766 ± 0.035	0.0LysXaa: 0.0 ± 0.0
Leu	10.31LeuAla: 10.31 ± 0.106	0.865LeuCys: 0.865 ± 0.027	5.758LeuAsp: 5.758 ± 0.071	5.428LeuGlu: 5.428 ± 0.074	4.014LeuPhe: 4.014 ± 0.067	5.836LeuGly: 5.836 ± 0.071	1.919LeuHis: 1.919 ± 0.041	6.089LeuIle: 6.089 ± 0.089	5.586LeuLys: 5.586 ± 0.066	9.567LeuLeu: 9.567 ± 0.118	2.256LeuMet: 2.256 ± 0.041	5.272LeuAsn: 5.272 ± 0.056	4.404LeuPro: 4.404 ± 0.056	4.357LeuGln: 4.357 ± 0.059	3.595LeuArg: 3.595 ± 0.057	7.352LeuSer: 7.352 ± 0.082	6.518LeuThr: 6.518 ± 0.077	6.809LeuVal: 6.809 ± 0.079	0.957LeuTrp: 0.957 ± 0.03	2.883LeuTyr: 2.883 ± 0.049	0.0LeuXaa: 0.0 ± 0.0
Met	2.054MetAla: 2.054 ± 0.037	0.174MetCys: 0.174 ± 0.012	1.057MetAsp: 1.057 ± 0.029	0.957MetGlu: 0.957 ± 0.03	0.838MetPhe: 0.838 ± 0.026	1.372MetGly: 1.372 ± 0.035	0.515MetHis: 0.515 ± 0.02	1.111MetIle: 1.111 ± 0.03	1.15MetLys: 1.15 ± 0.032	2.464MetLeu: 2.464 ± 0.044	0.526MetMet: 0.526 ± 0.02	0.995MetAsn: 0.995 ± 0.027	1.172MetPro: 1.172 ± 0.033	1.427MetGln: 1.427 ± 0.03	1.005MetArg: 1.005 ± 0.024	1.649MetSer: 1.649 ± 0.031	1.273MetThr: 1.273 ± 0.03	1.456MetVal: 1.456 ± 0.034	0.227MetTrp: 0.227 ± 0.015	0.562MetTyr: 0.562 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	3.865AsnAla: 3.865 ± 0.053	0.516AsnCys: 0.516 ± 0.021	2.477AsnAsp: 2.477 ± 0.055	2.467AsnGlu: 2.467 ± 0.044	2.067AsnPhe: 2.067 ± 0.045	3.414AsnGly: 3.414 ± 0.067	1.112AsnHis: 1.112 ± 0.027	3.357AsnIle: 3.357 ± 0.055	3.233AsnLys: 3.233 ± 0.052	4.968AsnLeu: 4.968 ± 0.066	1.066AsnMet: 1.066 ± 0.026	2.872AsnAsn: 2.872 ± 0.064	2.266AsnPro: 2.266 ± 0.044	3.224AsnGln: 3.224 ± 0.059	2.022AsnArg: 2.022 ± 0.039	3.186AsnSer: 3.186 ± 0.066	2.676AsnThr: 2.676 ± 0.055	2.779AsnVal: 2.779 ± 0.043	0.862AsnTrp: 0.862 ± 0.025	1.877AsnTyr: 1.877 ± 0.039	0.0AsnXaa: 0.0 ± 0.0
Pro	3.159ProAla: 3.159 ± 0.062	0.293ProCys: 0.293 ± 0.013	2.333ProAsp: 2.333 ± 0.044	2.95ProGlu: 2.95 ± 0.073	1.58ProPhe: 1.58 ± 0.034	1.942ProGly: 1.942 ± 0.044	0.873ProHis: 0.873 ± 0.025	2.485ProIle: 2.485 ± 0.046	1.933ProLys: 1.933 ± 0.042	3.412ProLeu: 3.412 ± 0.051	0.823ProMet: 0.823 ± 0.026	2.099ProAsn: 2.099 ± 0.038	1.054ProPro: 1.054 ± 0.028	1.857ProGln: 1.857 ± 0.038	1.151ProArg: 1.151 ± 0.032	2.426ProSer: 2.426 ± 0.049	2.211ProThr: 2.211 ± 0.046	2.838ProVal: 2.838 ± 0.039	0.512ProTrp: 0.512 ± 0.023	1.329ProTyr: 1.329 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	5.658GlnAla: 5.658 ± 0.08	0.382GlnCys: 0.382 ± 0.017	2.391GlnAsp: 2.391 ± 0.039	2.065GlnGlu: 2.065 ± 0.042	2.159GlnPhe: 2.159 ± 0.044	3.188GlnGly: 3.188 ± 0.049	1.503GlnHis: 1.503 ± 0.036	3.496GlnIle: 3.496 ± 0.049	2.519GlnLys: 2.519 ± 0.048	6.286GlnLeu: 6.286 ± 0.091	1.122GlnMet: 1.122 ± 0.032	2.579GlnAsn: 2.579 ± 0.049	2.091GlnPro: 2.091 ± 0.036	5.068GlnGln: 5.068 ± 0.103	2.04GlnArg: 2.04 ± 0.039	3.379GlnSer: 3.379 ± 0.054	3.236GlnThr: 3.236 ± 0.059	3.802GlnVal: 3.802 ± 0.061	0.694GlnTrp: 0.694 ± 0.027	1.774GlnTyr: 1.774 ± 0.038	0.0GlnXaa: 0.0 ± 0.0
Arg	3.032ArgAla: 3.032 ± 0.046	0.342ArgCys: 0.342 ± 0.015	2.083ArgAsp: 2.083 ± 0.04	2.29ArgGlu: 2.29 ± 0.043	1.994ArgPhe: 1.994 ± 0.04	2.234ArgGly: 2.234 ± 0.043	0.913ArgHis: 0.913 ± 0.025	2.766ArgIle: 2.766 ± 0.046	2.266ArgLys: 2.266 ± 0.042	4.206ArgLeu: 4.206 ± 0.062	0.973ArgMet: 0.973 ± 0.025	1.86ArgAsn: 1.86 ± 0.042	1.483ArgPro: 1.483 ± 0.034	2.086ArgGln: 2.086 ± 0.047	1.844ArgArg: 1.844 ± 0.04	2.346ArgSer: 2.346 ± 0.048	1.886ArgThr: 1.886 ± 0.039	2.773ArgVal: 2.773 ± 0.048	0.552ArgTrp: 0.552 ± 0.021	1.624ArgTyr: 1.624 ± 0.033	0.0ArgXaa: 0.0 ± 0.0
Ser	5.892SerAla: 5.892 ± 0.078	0.668SerCys: 0.668 ± 0.023	3.665SerAsp: 3.665 ± 0.065	3.842SerGlu: 3.842 ± 0.057	2.978SerPhe: 2.978 ± 0.05	4.629SerGly: 4.629 ± 0.073	1.398SerHis: 1.398 ± 0.034	4.383SerIle: 4.383 ± 0.067	3.505SerLys: 3.505 ± 0.054	6.622SerLeu: 6.622 ± 0.072	1.431SerMet: 1.431 ± 0.03	3.078SerAsn: 3.078 ± 0.06	2.251SerPro: 2.251 ± 0.047	3.493SerGln: 3.493 ± 0.055	2.537SerArg: 2.537 ± 0.044	4.336SerSer: 4.336 ± 0.078	3.359SerThr: 3.359 ± 0.06	4.637SerVal: 4.637 ± 0.063	0.919SerTrp: 0.919 ± 0.03	2.228SerTyr: 2.228 ± 0.042	0.0SerXaa: 0.0 ± 0.0
Thr	4.811ThrAla: 4.811 ± 0.067	0.457ThrCys: 0.457 ± 0.018	3.449ThrAsp: 3.449 ± 0.068	3.213ThrGlu: 3.213 ± 0.044	2.165ThrPhe: 2.165 ± 0.044	4.114ThrGly: 4.114 ± 0.062	1.254ThrHis: 1.254 ± 0.028	3.447ThrIle: 3.447 ± 0.057	2.463ThrLys: 2.463 ± 0.049	5.478ThrLeu: 5.478 ± 0.078	1.006ThrMet: 1.006 ± 0.025	2.592ThrAsn: 2.592 ± 0.05	2.506ThrPro: 2.506 ± 0.041	2.872ThrGln: 2.872 ± 0.049	1.99ThrArg: 1.99 ± 0.041	3.624ThrSer: 3.624 ± 0.074	3.107ThrThr: 3.107 ± 0.059	3.629ThrVal: 3.629 ± 0.065	0.66ThrTrp: 0.66 ± 0.023	1.652ThrTyr: 1.652 ± 0.041	0.0ThrXaa: 0.0 ± 0.0
Val	6.038ValAla: 6.038 ± 0.078	0.742ValCys: 0.742 ± 0.026	4.278ValAsp: 4.278 ± 0.064	4.856ValGlu: 4.856 ± 0.067	2.771ValPhe: 2.771 ± 0.045	4.135ValGly: 4.135 ± 0.07	1.269ValHis: 1.269 ± 0.031	4.321ValIle: 4.321 ± 0.064	3.866ValLys: 3.866 ± 0.061	6.184ValLeu: 6.184 ± 0.085	1.477ValMet: 1.477 ± 0.038	3.335ValAsn: 3.335 ± 0.046	2.28ValPro: 2.28 ± 0.046	2.495ValGln: 2.495 ± 0.048	2.629ValArg: 2.629 ± 0.047	4.799ValSer: 4.799 ± 0.074	3.975ValThr: 3.975 ± 0.069	5.076ValVal: 5.076 ± 0.074	0.763ValTrp: 0.763 ± 0.024	2.133ValTyr: 2.133 ± 0.041	0.0ValXaa: 0.0 ± 0.0
Trp	0.845TrpAla: 0.845 ± 0.026	0.148TrpCys: 0.148 ± 0.011	0.644TrpAsp: 0.644 ± 0.024	0.417TrpGlu: 0.417 ± 0.018	0.657TrpPhe: 0.657 ± 0.021	0.762TrpGly: 0.762 ± 0.029	0.413TrpHis: 0.413 ± 0.016	0.667TrpIle: 0.667 ± 0.024	0.506TrpLys: 0.506 ± 0.023	1.782TrpLeu: 1.782 ± 0.045	0.303TrpMet: 0.303 ± 0.013	0.49TrpAsn: 0.49 ± 0.022	0.523TrpPro: 0.523 ± 0.022	1.26TrpGln: 1.26 ± 0.033	0.688TrpArg: 0.688 ± 0.025	0.804TrpSer: 0.804 ± 0.025	0.571TrpThr: 0.571 ± 0.024	0.876TrpVal: 0.876 ± 0.024	0.201TrpTrp: 0.201 ± 0.013	0.479TrpTyr: 0.479 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.588TyrAla: 2.588 ± 0.046	0.394TyrCys: 0.394 ± 0.017	1.768TyrAsp: 1.768 ± 0.04	1.516TyrGlu: 1.516 ± 0.035	1.616TyrPhe: 1.616 ± 0.03	2.073TyrGly: 2.073 ± 0.043	0.849TyrHis: 0.849 ± 0.03	1.978TyrIle: 1.978 ± 0.038	1.776TyrLys: 1.776 ± 0.039	3.618TyrLeu: 3.618 ± 0.056	0.64TyrMet: 0.64 ± 0.02	1.487TyrAsn: 1.487 ± 0.043	1.438TyrPro: 1.438 ± 0.033	2.663TyrGln: 2.663 ± 0.055	1.668TyrArg: 1.668 ± 0.035	2.285TyrSer: 2.285 ± 0.049	1.768TyrThr: 1.768 ± 0.037	1.972TyrVal: 1.972 ± 0.042	0.572TyrTrp: 0.572 ± 0.02	1.294TyrTyr: 1.294 ± 0.04	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3835 proteins (1380918 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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